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Parental mutations influence wild-type offspring via transcriptional adaptation
Jiang, Zhen El-Brolosy, Mohamed A. Serobyan, Vahan Welker, Jordan M. Retzer, Nicholas Dooley, Christopher M. Jakutis, Gabrielius Juan, Thomas Fukuda, Nana Maischein, Hans-Martin
Jiang, Zhen
El-Brolosy, Mohamed A.
Serobyan, Vahan
Welker, Jordan M.
Retzer, Nicholas
Dooley, Christopher M.
Jakutis, Gabrielius
Juan, Thomas
Fukuda, Nana
Maischein, Hans-Martin
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Journal article
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2022-11-25
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Biology
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http://dx.doi.org/10.1126/sciadv.abj2029
Abstract
Transgenerational epigenetic inheritance (TEI) is mostly discussed in the context of physiological or environmental factors. Here, we show intergenerational and transgenerational inheritance of transcriptional adaptation (TA), a process whereby mutant messenger RNA (mRNA) degradation affects gene expression, in nematodes and zebrafish. Wild-type offspring of animals heterozygous for mRNA-destabilizing alleles display increased expression of adapting genes. Notably, offspring of animals heterozygous for nontranscribing alleles do not display this response. Germline-specific mutations are sufficient to induce TA in wild-type offspring, indicating that, at least for some genes, mutations in somatic tissues are not necessary for this process. Microinjecting total RNA from germ cells of TA-displaying heterozygous zebrafish can trigger TA in wild-type embryos and in their progeny, suggesting a model whereby mutant mRNAs in the germline trigger a TA response that can be epigenetically inherited. In sum, this previously unidentified mode of TEI reveals a means by which parental mutations can modulate the offspring’s transcriptome.
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Zhen Jiang et al. ,Parental mutations influence wild-type offspring via transcriptional adaptation.Sci. Adv.8,eabj2029(2022).DOI:10.1126/sciadv.abj2029
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American Association for the Advancement of Science (AAAS)
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Science Advances, Vol. 8, Iss. 47
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