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Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19

; 
Patel, Kena
; 
Ho, Wenzhe
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Luo, Jin Jun
; 
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Genre
Post-print
Date
2020-12-10
Advisor
Committee member
Group
Center for Metabolic Disease Research (Temple University)
Department
Pathology and Laboratory Medicine
Neurology and Pharmacology
Subject
Brain organoids
 COVID‐19
 iPS cells
 Neural cells
 Neuroinvasion
 Neurology
 Neuropsychiatry
 Neurovirulence
 SARS‐CoV‐2
Permanent link to this record
http://hdl.handle.net/20.500.12613/6260
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COVID-19 Research
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Hu-PostPrint-2020-12.pdf
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DOI
https://doi.org/10.1002/jmv.26720
Abstract
Patients with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection manifest mainly respiratory symptoms. However, clinical observations frequently identified neurological symptoms and neuropsychiatric disorders related to COVID‐19 (Neuro‐SARS2). Accumulated robust evidence indicates that Neuro‐SARS2 may play an important role in aggravating the disease severity and mortality. Understanding the neuropathogenesis and cellular mechanisms underlying Neuro‐SARS2 is crucial for both basic research and clinical practice to establish effective strategies for early detection/diagnosis, prevention, and treatment. In this review, we comprehensively examine current evidence of SARS‐CoV‐2 infection in various neural cells including neurons, microglia/macrophages, astrocytes, pericytes/endothelial cells, ependymocytes/choroid epithelial cells, and neural stem/progenitor cells. Although significant progress has been made in studying Neuro‐SARS2, much remains to be learned about the neuroinvasive routes (transneuronal and hematogenous) of the virus and the cellular/molecular mechanisms underlying the development/progression of this disease. Future and ongoing studies require the establishment of more clinically relevant and suitable neural cell models using human induced pluripotent stem cells, brain organoids, and postmortem specimens.
Description
Citation
This is the peer reviewed version of the following article: Bodnar, B., Patel, K., Ho, W., Luo, J.J., and Hu, W. (2020). Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19. Journal of Medical Virology 93, 1983–1998. https://doi.org/10.1002/jmv.26720
Citation to related work
Wiley
Has part
Journal of Medical Virology, Vol. 93, Iss. 4
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