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Chronic paternal morphine exposure increases sensitivity to morphine-derived pain relief in male progeny

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Foster, William
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Jones, Jessica M.
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Kaufmann, Samuel
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Wachira, Meghan
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Hughes, Robert
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Bongiovanni, Angela R.
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Famularo, Sydney T.
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Dunham, Benjamin P.
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Schwark, Ryan
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Journal article
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2022-02-16
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Psychology and Neuroscience
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http://hdl.handle.net/20.500.12613/9372
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ToussaintEtAl-JournalArticle-2022-02.pdf
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http://dx.doi.org/10.1126/sciadv.abk2425
Abstract
Parental history of opioid exposure is seldom considered when prescribing opioids for pain relief. To explore whether parental opioid exposure may affect sensitivity to morphine in offspring, we developed a “rat pain scale” with high-speed imaging, machine learning, and mathematical modeling in a multigenerational model of pater-nal morphine self-administration. We find that the most commonly used tool to measure mechanical sensitivity in rodents, the von Frey hair, is not painful in rats during baseline conditions. We also find that male progeny of morphine-treated sires had no baseline changes in mechanical pain sensitivity but were more sensitive to the pain-relieving effects of morphine. Using RNA sequencing across pain-relevant brain regions, we identify gene expression changes within the regulator of G protein signaling family of proteins that may underlie this multigen-erational phenotype. Together, this rat pain scale revealed that paternal opioid exposure increases sensitivity to morphine’s pain-relieving effects in male offspring.
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Andre B. Toussaint et al. ,Chronic paternal morphine exposure increases sensitivity to morphine-derived pain relief in male progeny.Sci. Adv.8,eabk2425(2022).DOI:10.1126/sciadv.abk2425
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American Association for the Advancement of Science (AAAS)
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Science Advances, Vol. 8, Iss. 7
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