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Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits
Moore, AR Richards, SE Kenny, K Royer, L Chan, U Flavahan, K Van Hooser, SD Paradis, S
Moore, AR
Richards, SE
Kenny, K
Royer, L
Chan, U
Flavahan, K
Van Hooser, SD
Paradis, S
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Genre
Journal Article
Date
2018-05-29
Advisor
Committee member
Group
Department
Subject
Rem2
activity-dependent
homeostasis
intrinsic excitability
mouse
neuroscience
plasticity
Action Potentials
Animals
Female
Gene Expression Regulation
Male
Mice
Mice, Knockout
Monomeric GTP-Binding Proteins
Nerve Net
Neuronal Plasticity
Primary Cell Culture
Pyramidal Cells
Rats
Sensory Receptor Cells
Synapses
Visual Cortex
activity-dependent
homeostasis
intrinsic excitability
mouse
neuroscience
plasticity
Action Potentials
Animals
Female
Gene Expression Regulation
Male
Mice
Mice, Knockout
Monomeric GTP-Binding Proteins
Nerve Net
Neuronal Plasticity
Primary Cell Culture
Pyramidal Cells
Rats
Sensory Receptor Cells
Synapses
Visual Cortex
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DOI
10.7554/eLife.33092
Abstract
© Moore et al. Sensory experience plays an important role in shaping neural circuitry by affecting the synaptic connectivity and intrinsic properties of individual neurons. Identifying the molecular players responsible for converting external stimuli into altered neuronal output remains a crucial step in understanding experience-dependent plasticity and circuit function. Here, we investigate the role of the activity-regulated, non-canonical Ras-like GTPase Rem2 in visual circuit plasticity. We demonstrate that Rem2 -/- mice fail to exhibit normal ocular dominance plasticity during the critical period. At the cellular level, our data establish a cell-autonomous role for Rem2 in regulating intrinsic excitability of layer 2/3 pyramidal neurons, prior to changes in synaptic function. Consistent with these findings, both in vitro and in vivo recordings reveal increased spontaneous firing rates in the absence of Rem2. Taken together, our data demonstrate that Rem2 is a key molecule that regulates neuronal excitability and circuit function in the context of changing sensory experience.
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eLife Sciences Publications, Ltd
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