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Real-world Adherence to Nusinersen in Adults with Spinal Muscular Atrophy in the US: A Multi-site Chart Review Study
Elman, Lauren Youn, Bora Proud, Crystal M. Frey, Margaret R. Ajroud-Driss, Senda McCormick, M. Eileen Michelson, David Cartwright, Michael S. Heiman-Patterson, Terry Choi, Joseph M.
Elman, Lauren
Youn, Bora
Proud, Crystal M.
Frey, Margaret R.
Ajroud-Driss, Senda
McCormick, M. Eileen
Michelson, David
Cartwright, Michael S.
Heiman-Patterson, Terry
Choi, Joseph M.
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Journal article
Date
2022-09-09
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Neurology
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DOI
http://dx.doi.org/10.3233/jnd-210768
Abstract
Limited evidence exists on real-world adherence to nusinersen for the treatment of spinal muscular atrophy (SMA). Data are presented from a multi-site retrospective chart review of 86 adults with SMA initiating nusinersen at nine US centers between January 2017 and February 2019. Seventy-nine (92%) adults remained on nusinersen during the study; 454 (92%) of 493 total nusinersen doses were received on time. Fifty-eight (67%) adults received all nusinersen doses on time. The majority of patients with at least one nonadherent dose resumed nusinersen on time. Most patients followed the dosing schedule across the loading and maintenance dose periods.
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Citation
Elman, Lauren et al. ‘Real-world Adherence to Nusinersen in Adults with Spinal Muscular Atrophy in the US: A Multi-site Chart Review Study’. 1 Jan. 2022 : 655 – 660.
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IOS Press
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Journal of Neuromuscular Diseases, Vol. 9, No. 5
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