Thumbnail Image
Item

TRPV1: A target for rational drug design

Carnevale, V
; 
Rohacs, T
Citations
Altmetric:
Genre
Review
Journal
Date
2016-09-23
Advisor
Committee member
Group
Department
Subject
TRPV1
 capsaicin
 nociception
 pain
 vanilloid
Permanent link to this record
http://hdl.handle.net/20.500.12613/5033
Collections
Faculty/Researcher Works
Show all metadata
Files
Thumbnail Image
TRPV1 A Target for Rational Drug Design.pdf
Adobe PDF, 1.28 MB
Research Projects
Organizational Units
Journal Issue
DOI
10.3390/ph9030052
Abstract
© 2016 by the authors; licensee MDPI, Basel, Switzerland. Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca2+ permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX). Many compounds have been developed that either activate or inhibit TRPV1, but none of them are in routine clinical practice. This review will discuss the rationale for antagonists and agonists of TRPV1 for pain relief and other conditions, and strategies to develop new, better drugs to target this ion channel, using the newly available high-resolution structures.
Description
Citation
Citation to related work
MDPI AG
Has part
Pharmaceuticals
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
Embedded videos