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In-hospital mortality of COVID-19 patients hospitalized with ST-segment elevation myocardial infarction: A meta-analysis
Cheema, Huzaifa Ahmad Ehsan, Muhammad Ayyan, Muhammad Shahid, Abia Farooq, Minaam Javed, Muhammad Usman Lak, Hassan Mehmood Ahmad, Malik Qistas Virk, Hafeez Ul Hassan Lakhter, Vladimir
Cheema, Huzaifa Ahmad
Ehsan, Muhammad
Ayyan, Muhammad
Shahid, Abia
Farooq, Minaam
Javed, Muhammad Usman
Lak, Hassan Mehmood
Ahmad, Malik Qistas
Virk, Hafeez Ul Hassan
Lakhter, Vladimir
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Journal article
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2022-11-19
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Medicine
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http://dx.doi.org/10.1016/j.ijcha.2022.101151
Abstract
Introduction: Coronavirus Disease 2019 (COVID-19) has been associated with an increased risk of adverse cardiovascular events including arteriovenous thrombosis, myocarditis and acute myocardial injury. Relevant literature to date has reported widely varying estimates of mortality, ranging from approximately 2 to 11 times higher odds of mortality in COVID-19-positive STEMI (ST-segment elevation myocardial infarction) patients. Hence, we conducted this meta-analysis to resolve these inconsistencies and assess the impact of COVID-19 infection on mortality and other clinical outcomes in patients presenting with STEMI. Methods: This meta-analysis was registered in PROSPERO (CRD42021297458) and performed according to the Cochrane Handbook for Systematic Reviews of Interventions. PubMed and Embase were searched from inception to November 2021 (updated on April 2022) using a search strategy consisting of terms relating to COVID-19, STEMI, and mortality. Results: We identified 435 studies through our initial search. After screening according to our eligibility criteria, a total of 11 studies were included. Compared with the non-COVID-19 STEMI patients, the in-hospital mortality rate was higher in COVID-19-positive STEMI patients. Similarly, the risk of cardiogenic shock was higher in the COVID-19-positive patients. Length of hospital stay was longer in STEMI patients with COVID-19. Conclusions: Our study highlights the necessity for early evaluation of COVID-19 status in all STEMI patients followed by risk stratification, prompt reperfusion and more aggressive management of COVID-19-positive patients. Further research is needed to elucidate the mechanisms behind poorer prognosis in such patients.
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Huzaifa Ahmad Cheema, Muhammad Ehsan, Muhammad Ayyan, Abia Shahid, Minaam Farooq, Muhammad Usman Javed, Hassan Mehmood Lak, Malik Qistas Ahmad, Hafeez Ul Hassan Virk, Vladimir Lakhter, Ka Yiu Lee, In-hospital mortality of COVID-19 patients hospitalized with ST-segment elevation myocardial infarction: A meta-analysis, IJC Heart & Vasculature, Volume 43, 2022, 101151, ISSN 2352-9067, https://doi.org/10.1016/j.ijcha.2022.101151.
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Elsevier
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IJC Heart and Vasculature, Vol. 43
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