Loading...
Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder
Christian, Isaac Ray Liuzzi, Michael T. Yu, Qiongru Kryza-Lacombe, Maria Monk, Christopher S. Jarcho, Johanna Wiggins, Jillian Lee
Christian, Isaac Ray
Liuzzi, Michael T.
Yu, Qiongru
Kryza-Lacombe, Maria
Monk, Christopher S.
Jarcho, Johanna
Wiggins, Jillian Lee
Citations
Altmetric:
Genre
Journal article
Date
2022-01-17
Advisor
Committee member
Group
Department
Psychology and Neuroscience
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.1016/j.rasd.2021.101913
Abstract
Background: The amygdala-prefrontal cortex circuit is involved in processing socio-emotional cues and may partially mediate social impairment in autism spectrum disorder (ASD). Past task-based fMRI studies in ASD indicate a mix of hypo- and hyper-connectivity in response to socio-emotional stimuli whereas resting state studies report hypoconnectivity between these regions. However, it is still unknown whether ASD-related alterations in amygdala-prefrontal circuitry are present across socio-emotional tasks and resting state contexts within the same sample or instead, depend on context. Method: ASD (n = 47) and typically developing individuals (TD; n = 72) underwent fMRI during an implicit emotional face processing task and during rest, and whole-brain amygdala connectivity was calculated to determine patterns that differed by context and diagnosis. Results: Relative to TD, the ASD group demonstrated weaker left amygdala connectivity with the medial frontal gyrus and the left superior frontal gyrus during rest, but stronger connectivity during task. Furthermore, across both contexts, ASD vs. TD had stronger right amygdala connectivity with the left insula/superior temporal gyrus. Conclusion: Findings suggest some alterations in amygdala connectivity of ASD may depend on context while others are pervasive across task and rest conditions. Understanding context-dependent brain alterations in ASD may help disambiguate the mechanisms subserving social impairment and provide targets for treatment.
Description
Citation
Isaac Ray Christian, Michael T. Liuzzi, Qiongru Yu, Maria Kryza-Lacombe, Christopher S. Monk, Johanna Jarcho, Jillian Lee Wiggins, Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder, Research in Autism Spectrum Disorders, Volume 91, 2022, 101913, ISSN 1750-9467, https://doi.org/10.1016/j.rasd.2021.101913.
Citation to related work
Elsevier
Has part
Research in Autism Spectrum Disorders (RASD), Vol. 91
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu