Loading...
Comparison of Reproductive Function Between Normal and Hyperandrogenemia Conditions in Female Mice With Deletion of Hepatic Androgen Receptor
Feng, Mingxiao Divall, Sara Jones, Dustin Ubba, Vaibhave Fu, Xiaomin Wu, Sheng
Feng, Mingxiao
Divall, Sara
Jones, Dustin
Ubba, Vaibhave
Fu, Xiaomin
Wu, Sheng
Citations
Altmetric:
Genre
Journal article
Date
2022-06-09
Advisor
Committee member
Department
Cardiovascular Sciences
Medical Genetics and Molecular Biochemistry
Medical Genetics and Molecular Biochemistry
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.3389/fendo.2022.868572
Abstract
Obesity, altered glucose homeostasis, hyperinsulinism, and reproductive dysfunction develops in female humans and mammals with hyperandrogenism. We previously reported that low dose dihydrotestosterone (DHT) administration results in metabolic and reproductive dysfunction in the absence of obesity in female mice, and conditional knock-out of the androgen receptor (Ar) in the liver (LivARKO) protects female mice from DHT-induced glucose intolerance and hyperinsulinemia. Since altered metabolic function will regulate reproduction, and liver plays a pivotal role in the reversible regulation of reproductive function, we sought to determine the reproductive phenotype of LivARKO mice under normal and hyperandrogenemic conditions. Using Cre/Lox technology, we deleted the Ar in the liver, and we observed LivARKO female mice have normal puberty timing, cyclicity and reproductive function. After DHT treatment, like control mice, LivARKO experience altered estrous cycling, reduced numbers of corpus lutea, and infertility. Liver Ar is not involved in hyperandrogenemia-induced reproductive dysfunction. The reproductive dysfunction in the DHT-treated LivARKO lean females with normal glucose homeostasis indicates that androgen-induced reproductive dysfunction is independent from metabolic dysfunction.
Description
Citation
Feng M, Divall S, Jones D, Ubba V, Fu X, Yang L, Wang H, Yang X and Wu S (2022) Comparison of Reproductive Function Between Normal and Hyperandrogenemia Conditions in Female Mice With Deletion of Hepatic Androgen Receptor. Front. Endocrinol. 13:868572. doi: 10.3389/fendo.2022.868572
Citation to related work
Frontiers Media
Has part
Frontiers in Endocrinology, Vol. 13
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu