Loading...
Editorial: Advances in CNS Repair, Regeneration, and Neuroplasticity: From Basic Mechanisms to Therapeutic Strategies
Li, Shuxin
Li, Shuxin
Citations
Altmetric:
Genre
Journal article
Date
2022-05-27
Advisor
Committee member
Department
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.3389/fncel.2022.898546
Abstract
Loss of neural cells and neuronal networks in the CNS frequently results in permanent functional deficits with minimal recovery. Current treatments for patients suffering from neurological functional deficits are largely limited. Recent studies have provided insight into secondary injury mechanisms and signaling pathways for controlling CNS repair and regeneration. Researchers have identified new molecular and cellular targets and effective therapeutic strategies for promoting cell survival, CNS regeneration, neural circuit reconnections, remyelination, and neuroplasticity in adult CNS. This Research Topic focuses on recent preclinical research advances in CNS repair, regeneration, and neuroplasticity. We published 29 articles on this Research Topic, including 17 reviews and 12 original research articles. These studies targeted multiple molecular and cellular components using several model systems, including traumatic brain injury (TBI), spinal cord injury (SCI), optic nerve crush (ONC), neurodegeneration, and in vitro cell cultures. Many articles focused on enhancing viability of neural cells and regeneration, reconnection, and plasticity of injured CNS neurons by targeting diverse CNS pathophysiology, including inflammatory cascades and regeneration failure of axotomized CNS axons.
Description
Citation
Li S (2022) Editorial: Advances in CNS Repair, Regeneration, and Neuroplasticity: From Basic Mechanisms to Therapeutic Strategies. Front. Cell. Neurosci. 16:898546. doi: 10.3389/fncel.2022.898546
Citation to related work
Frontiers Media
Has part
Frontiers in Cellular Neuroscience, Vol. 16
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu