Loading...
Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade
Tachibana, SI Sullivan, SA Kawai, S Nakamura, S Kim, HR Goto, N Arisue, N Palacpac, NMQ Honma, H Yagi, M
Tachibana, SI
Sullivan, SA
Kawai, S
Nakamura, S
Kim, HR
Goto, N
Arisue, N
Palacpac, NMQ
Honma, H
Yagi, M
Citations
Altmetric:
Genre
Journal Article
Date
2012-09-01
Advisor
Committee member
Group
Department
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
10.1038/ng.2375
Abstract
P. cynomolgi, a malaria-causing parasite of Asian Old World monkeys, is the sister taxon of P. vivax, the most prevalent malaria-causing species in humans outside of Africa. Because P. cynomolgi shares many phenotypic, biological and genetic characteristics with P. vivax, we generated draft genome sequences for three P. cynomolgi strains and performed genomic analysis comparing them with the P. vivax genome, as well as with the genome of a third previously sequenced simian parasite, Plasmodium knowlesi. Here, we show that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes. We identify genome-wide SNPs, microsatellites and CNVs in the P. cynomolgi genome, providing a map of genetic variation that can be used to map parasite traits and study parasite populations. The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax. © 2012 Nature America, Inc. All rights reserved.
Description
Citation
Citation to related work
Springer Science and Business Media LLC
Has part
Nature Genetics
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu