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Graph-generative neural network for EEG-based epileptic seizure detection via discovery of dynamic brain functional connectivity

Li, Zhengdao
; 
Hwang, Kai
; 
Li, Keqin
; ; 
Ji, Tongkai
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Journal article
Date
2022-11-08
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Computer and Information Sciences
Subject
Electroencephalography – EEG
 Epilepsy
 Machine learning
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http://hdl.handle.net/20.500.12613/10018
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WuEtAl-JournalArticle-2022-11.pdf
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http://dx.doi.org/10.1038/s41598-022-23656-1
Abstract
Dynamic complexity in brain functional connectivity has hindered the effective use of signal processing or machine learning methods to diagnose neurological disorders such as epilepsy. This paper proposed a new graph-generative neural network (GGN) model for the dynamic discovery of brain functional connectivity via deep analysis of scalp electroencephalogram (EEG) signals recorded from various regions of a patient’s scalp. Brain functional connectivity graphs are generated for the extraction of spatial–temporal resolution of various onset epilepsy seizure patterns. Our supervised GGN model was substantiated by seizure detection and classification experiments. We train the GGN model using a clinically proven dataset of over 3047 epileptic seizure cases. The GGN model achieved a 91% accuracy in classifying seven types of epileptic seizure attacks, which outperformed the 65%, 74%, and 82% accuracy in using the convolutional neural network (CNN), graph neural networks (GNN), and transformer models, respectively. We present the GGN model architecture and operational steps to assist neuroscientists or brain specialists in using dynamic functional connectivity information to detect neurological disorders. Furthermore, we suggest to merge our spatial–temporal graph generator design in upgrading the conventional CNN and GNN models with dynamic convolutional kernels for accuracy enhancement.
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Li, Z., Hwang, K., Li, K. et al. Graph-generative neural network for EEG-based epileptic seizure detection via discovery of dynamic brain functional connectivity. Sci Rep 12, 18998 (2022). https://doi.org/10.1038/s41598-022-23656-1
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Nature Research
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Scientific Reports, Vol. 12
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