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Deregulation of dicer and mir-155 expression in liposarcoma
Vincenzi, B Iuliani, M Zoccoli, A Pantano, F Fioramonti, M de Lisi, D Frezza, AM Rabitti, C Perrone, G Muda, AO
Vincenzi, B
Iuliani, M
Zoccoli, A
Pantano, F
Fioramonti, M
de Lisi, D
Frezza, AM
Rabitti, C
Perrone, G
Muda, AO
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Journal Article
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2015-01-01
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10.18632/oncotarget.3201
Abstract
Liposarcoma (LPS) is the most common soft tissue sarcoma. It has been demonstrated that mir-155 was the most overexpressed miRNA in well-differentiated LPS(WDLPS)/dedifferentiated LPS (DDLPS). The aim of this study is to evaluate the involvement of Dicer, Drosha and mir-155 in development of LPS and their possible role in stratification of different histological subtypes. Dicer, Drosha and mir-155 mRNA levels were analyzed in formalin-fixed paraffin-embedded specimens from patients diagnosed with 62 LPS and compared with samples of adipose tissues of healthy donors. The experimental data were obtained using qRT-PCR comparing Dicer, Drosha and mir-155 expression levels in tumor samples versus normal fat. The tumor samples from LPS patients showed a significantly lower Dicer expression versus normal adipose tissue, while Drosha levels did not differ. Concerning mir155 expression levels, our results demonstrated a significant mir-155 up-regulation in all LPS subtypes versus normal adipose tissue except for WDLS. These findings demonstrate for the first time that Dicer is deregulated in LPS and show that mir-155 is differentially expressed in LPS subgroups and it could be a promising tool to improve LPS disease stratification and differential diagnosis.
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