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HACE1, a Novel Repressor of RAR Transcriptional Activity
Zhao, Jianhua
Zhao, Jianhua
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Thesis/Dissertation
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2009
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Microbiology and Immunology
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http://dx.doi.org/10.34944/dspace/3916
Abstract
The biological activities of retinoic acid (RA) and its synthetic analogues are mediated through nuclear receptors, termed retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The transcriptional activity of RAR on target gene expression is achieved by its AF-1 domain and AF-2 domain. The function of AF-2 is known to be mediated by a number of coregulatory proteins. However the mechanism of AF-1 function is not well studied. We have hypothesized that the AF-1 function of RAR is regulated by specific interacting proteins. HACE1 was identified as an AF-1 domain interacting protein in a yeast two-hybrid screen. HACE1 interacts with RAR&beta<sub>3
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