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Selective Modulation of Talin-Integrin Interactions by Cyanidin Derivatives: Implications for Cancer Therapeutics
Kabir, Salvin
Kabir, Salvin
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Research project
Date
2024
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Committee member
Department
Biology
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http://dx.doi.org/10.34944/dspace/10133
Abstract
This thesis studies the complex relationships between talin—a critical protein involved in integrin activation and cell adhesion—and derivatives of Cyanidin-3-glucoside chloride (C3G), concentrating on their potential as cancer treatments. Talin plays a critical function in cell motility, invasion, and metastasis through its interaction with integrin β subunits. The focus of our work is to examine the impact of C3G derivatives, namely Cyanidin chloride (CC) and Pelargonidin chloride (PC), on the talin-integrin complex. This complex plays a crucial role in regulating the behavior of cancer cells. We employ advanced biochemical techniques to generate and purify talin proteins and utilize a fluorescence polarization assay to assess the binding affinities and inhibitory effects of these drugs. The research discloses a compound-specific modulation of talin activity in an isoform-specific manner, where CC exhibits a substantial effect on the talin1 isoform (TLN1) while PC demonstrates greater efficacy on the talin2 isoform (TLN2). This emphasis highlights the significance of customizing therapeutic approaches to utilize the unique molecular interactions involved, indicating a direction for the development of more precise and efficient cancer treatments. The findings presented here contribute to a deeper understanding of talin's biological roles and highlight its potential for therapeutic applications. These findings support the need for a targeted approach in the development of innovative medicines to address disorders involving talin interaction.
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