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Amyloid-containing biofilms and autoimmunity
de Anda, Jaime Wong, Gerard C.L. Tükel, Çagla
de Anda, Jaime
Wong, Gerard C.L.
Tükel, Çagla
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Journal article
Date
2022-07-18
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Microbiology, Immunology and Inflammation
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http://dx.doi.org/10.1016/j.sbi.2022.102435
Abstract
Bacteria are microscopic, single-celled organisms known for their ability to adapt to their environment. In response to stressful environmental conditions or in the presence of a contact surface, they commonly form multicellular aggregates called biofilms. Biofilms form on various abiotic or biotic surfaces through a dynamic stepwise process involving adhesion, growth, and extracellular matrix production. Biofilms develop on tissues as well as on implanted devices during infections, providing the bacteria with a mechanism for survival under harsh conditions including targeting by the immune system and antimicrobial therapy. Like pathogenic bacteria, members of the human microbiota can form biofilms. Biofilms formed by enteric bacteria contribute to several human diseases including autoimmune diseases and cancer. However, until recently the interactions of immune cells with biofilms had been mostly uncharacterized. Here, we will discuss how components of the enteric biofilm produced in vivo, specifically amyloid curli and extracellular DNA, could be interacting with the host's immune system causing an unpredicted immune response.
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Amanda L. Miller, Jaime de Anda, Gerard C.L. Wong, Çagla Tükel, Amyloid-containing biofilms and autoimmunity, Current Opinion in Structural Biology, Volume 75, 2022,102435, ISSN 0959-440X, https://doi.org/10.1016/j.sbi.2022.102435.
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Elsevier
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Current Opinion in Structural Biology (COSB), Vol. 75
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