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Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids
Natarajaseenivasan, Kalimuthusamy Garcia, Alvaro Velusamy, Prema Langford, Dianne
Natarajaseenivasan, Kalimuthusamy
Garcia, Alvaro
Velusamy, Prema
Langford, Dianne
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Journal article
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2022-11-04
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Neural Sciences
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http://dx.doi.org/10.1016/j.isci.2022.105407
Abstract
Disturbances in lipid metabolism in the CNS contribute to neurodegeneration and cognitive impairments. Through tight metabolic coupling, astrocytes provide energy to neurons by delivering lactate and cholesterol and by taking up and processing neuron-derived peroxidated fatty acids (pFA). Disruption of CNS lipid homeostasis is observed in people who use cocaine and in several neurodegenerative disorders, including HIV. The brain’s main source of energy is aerobic glycolysis, but numerous studies report a switch to β-oxidation of FAs in response to cocaine. Unlike astrocytes, in response to cocaine, neurons cannot efficiently consume excess pFAs for energy. Accumulation of pFA in neurons induces autophagy and release of pFA. Astrocytes endocytose the pFA for oxidation as an energy source. Our data show that blocking mitochondrial/cytosolic citrate transport reduces the neurotrophic capacity of astrocytes, leading to decreased neuronal fitness.
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Kalimuthusamy Natarajaseenivasan, Alvaro Garcia, Prema Velusamy, Santhanam Shanmughapriya, Dianne Langford, Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids, iScience, Volume 25, Issue 11, 2022, 105407, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2022.105407.
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Cell Press
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iScience, Vol. 25, Iss. 11
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