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The role of chlamydia trachomatis polymorphic membrane proteins in inflammation and sequelae among women with pelvic inflammatory disease
Taylor, BD Darville, T Tan, C Bavoil, PM Ness, RB Haggerty, CL
Taylor, BD
Darville, T
Tan, C
Bavoil, PM
Ness, RB
Haggerty, CL
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2011-12-01
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10.1155/2011/989762
Abstract
Chlamydia trachomatis polymorphic membrane proteins (Pmps) may increase genital tract inflammation and play a role in virulence. Antibody levels for PmpA, PmpD, and PmpI, measured in densitometric units, were assessed among a pilot sample of 40 C. trachomatis-infected women with mild-to-moderate clinical PID. Women who expressed antibodies to PmpA were less likely to achieve pregnancy (40.0 versus 85.7; P = 0.042) and less likely to have a live birth (0.0 versus 80.0; P = 0.005) compared to women who did not express antibody to PmpA. Women who expressed antibodies to PmpI were more likely to have upper genital tract infection (61.5 versus 20.0; P = 0.026). However, seropositivity to PmpI and PmpD did not modify the risk of reproductive sequelae or inflammation. Seropositivity to chlamydial PmpA may represent a biomarker of increased risk of sequelae secondary to infection with C. trachomatis. © 2011 Brandie D. Taylor et al.
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Infectious Diseases in Obstetrics and Gynecology
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