Loading...
Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers
Tanimoto, Ryuta Lu, Kuojung G. Xu, Shi-Qiong Buraschi, Simone Belfiore, Antonino Iozzzo, Renato V.
Tanimoto, Ryuta
Lu, Kuojung G.
Xu, Shi-Qiong
Buraschi, Simone
Belfiore, Antonino
Iozzzo, Renato V.
Citations
Altmetric:
Genre
Journal article
Date
2016-07-27
Advisor
Committee member
Group
Department
Biology
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.3389/fendo.2016.00100
Abstract
The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.
Description
Citation
Tanimoto R, Lu KG, Xu S-Q, Buraschi S, Belfiore A, Iozzo RV and Morrione A (2016) Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers. Front. Endocrinol. 7:100. doi: 10.3389/fendo.2016.00100
Citation to related work
Frontiers Media
Has part
Frontiers in Endocrinology, Vol. 7, No. 100
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu