Loading...
Experimental Parameterization of a Model of Hypoxia Dynamics in Yorkshire Swine
Wood, Sam Commins, Annina Doosthosseini, Mahsa Naselsky, Warren Culligan, Melissa Aroom, Kevin Aroom, Majid Kadkhodaeielyaderani, Behzad Moon, Yejin Leibowitz, Joshua
Wood, Sam
Commins, Annina
Doosthosseini, Mahsa
Naselsky, Warren
Culligan, Melissa
Aroom, Kevin
Aroom, Majid
Kadkhodaeielyaderani, Behzad
Moon, Yejin
Leibowitz, Joshua
Citations
Altmetric:
Genre
Journal article
Date
2022-11-29
Advisor
Committee member
Group
Department
Thoracic Medicine and Surgery
Subject
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.1016/j.ifacol.2022.11.272
Abstract
This paper estimates the parameters of a model of hypoxia in large animals (specifically, Yorkshire swine) from experimental data. The paper adopts a simple, control-oriented model of oxygen transport and consumption dynamics. The model uses three state variables to represent oxygen concentrations and/or partial pressures in the animal's alveolar, arterial, and venous compartments. Hypoxia is induced in a laboratory animal by placing the animal on mechanical ventilation and reducing the fraction of inspired oxygen. The resulting dataset is used for the optimal estimation of key parameters governing the animal's oxygen transport, oxygen consumption, and hemoglobin dissociation. In this nonlinear system identification exercise, the optimization objective is a weighted sum of the mean square errors in predicting (i) blood oxygen saturation and (ii) end-tidal oxygen fraction. The resulting model fits the experimental hypoxia data reasonably well, and is intended as a baseline for ongoing research on the treatment of respiratory failure.
Description
Citation
Sam Wood, Annina Commins, Mahsa Doosthosseini, Warren Naselsky, Melissa Culligan, Kevin Aroom, Majid Aroom, Behzad Kadkhodaeielyaderani, Yejin Moon, Joshua Leibowitz, Shelby Stewart, Miao Yu, Joseph Friedberg, Jin-Oh Hahn, Hosam K. Fathy, Experimental Parameterization of a Model of Hypoxia Dynamics in Yorkshire Swine, IFAC-PapersOnLine, Volume 55, Issue 37, 2022, Pages 752-757, ISSN 2405-8963, https://doi.org/10.1016/j.ifacol.2022.11.272.
Citation to related work
Elsevier
Has part
IFAC-PapersOnLine, Vol. 55, Iss. 37
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu