Loading...
Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd – 4th, 2021, Italy)
Ascierto, Paolo A. Agarwala, Sanjiv S. Blank, Christian Caraco, Corrado Carvajal, Richard D. Ernstoff, Marc S. Ferrone, Soldano Fox, Bernard A. Gajewski, Thomas F.. Garbe, Claus
Ascierto, Paolo A.
Agarwala, Sanjiv S.
Blank, Christian
Caraco, Corrado
Carvajal, Richard D.
Ernstoff, Marc S.
Ferrone, Soldano
Fox, Bernard A.
Gajewski, Thomas F..
Garbe, Claus
Citations
Altmetric:
Genre
Journal article
Date
2022-09-04
Advisor
Committee member
Group
Department
Medicine
Hematology and Medical Oncology
Hematology and Medical Oncology
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.1186/s12967-022-03592-4
Abstract
Advances in immune checkpoint and combination therapy have led to improvement in overall survival for patients with advanced melanoma. Improved understanding of the tumor, tumor microenvironment and tumor immune-evasion mechanisms has resulted in new approaches to targeting and harnessing the host immune response. Combination modalities with other immunotherapy agents, chemotherapy, radiotherapy, electrochemotherapy are also being explored to overcome resistance and to potentiate the immune response. In addition, novel approaches such as adoptive cell therapy, oncogenic viruses, vaccines and different strategies of drug administration including sequential, or combination treatment are being tested. Despite the progress in diagnosis of melanocytic lesions, correct classification of patients, selection of appropriate adjuvant and systemic theràapies, and prediction of response to therapy remain real challenges in melanoma. Improved understanding of the tumor microenvironment, tumor immunity and response to therapy has prompted extensive translational and clinical research in melanoma. There is a growing evidence that genomic and immune features of pre-treatment tumor biopsies may correlate with response in patients with melanoma and other cancers, but they have yet to be fully characterized and implemented clinically. Development of novel biomarker platforms may help to improve diagnostics and predictive accuracy for selection of patients for specific treatment. Overall, the future research efforts in melanoma therapeutics and translational research should focus on several aspects including: (a) developing robust biomarkers to predict efficacy of therapeutic modalities to guide clinical decision-making and optimize treatment regimens, (b) identifying mechanisms of therapeutic resistance to immune checkpoint inhibitors that are potentially actionable, (c) identifying biomarkers to predict therapy-induced adverse events, and (d) studying mechanism of actions of therapeutic agents and developing algorithms to optimize combination treatments. During the Melanoma Bridge meeting (December 2nd-4th, 2021, Naples, Italy) discussions focused on the currently approved systemic and local therapies for advanced melanoma and discussed novel biomarker strategies and advances in precision medicine as well as the impact of COVID-19 pandemic on management of melanoma patients.
Description
Citation
Ascierto, P.A., Agarwala, S.S., Blank, C. et al. Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd – 4th, 2021, Italy). J Transl Med 20, 391 (2022). https://doi.org/10.1186/s12967-022-03592-4
Citation to related work
BMC
Has part
Journal of Translational Medicine, Vol. 20, No. 391
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu