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Antineutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis as a Possible Side Effect of COVID-19 Vaccination
Noel, Edva Rashid, Urmiya Rabbani, Rizwan Khan, Waqas Ahmad Benjamin, Yves-Smith Lee, Iris
Noel, Edva
Rashid, Urmiya
Rabbani, Rizwan
Khan, Waqas Ahmad
Benjamin, Yves-Smith
Lee, Iris
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2022-10-21
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http://dx.doi.org/10.7759/cureus.30565
Abstract
Vaccination is the principal tool aimed at curbing the COVID-19 pandemic that has, so far, affected tens of millions of individuals in the United States. The two available mRNA vaccines developed by Pfizer-BioNTech and Moderna possess high efficacy in preventing infection and illness severity. However, there are multiple side effects associated with these vaccines, some impacting different organs. Renal pathology is variable, with increasing cases of glomerulonephritis being observed. We report a rare acute kidney injury case due to antineutrophil cytoplasmic autoantibody (ANCA)-mediated glomerulonephritis after administering a second dose of the Pfizer-BioNTech mRNA SARS-CoV-2 vaccine. Aggravation and/or development of autoimmunity after mRNA vaccination may involve multiple immune mechanisms leading to de novo and recurrent glomerular diseases with an autoimmune basis.
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Noel E, Rashid, Rabbani R, et al. (October 21, 2022) Antineutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis as a Possible Side Effect of COVID-19 Vaccination. Cureus 14(10): e30565. doi:10.7759/cureus.30565
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Cureus: Journal of Medical Science, Vol. 14
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