Thumbnail Image
Item

Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner

Alvarez, Pilar
; 
Citations
Altmetric:
Genre
Journal article
Date
2016-12-12
Advisor
Committee member
Group
Department
Microbiology and Immunology
Subject
Permanent link to this record
http://hdl.handle.net/20.500.12613/8383
Collections
Faculty/Researcher Works
Show all metadata
Files
Thumbnail Image
AlvarezJensen-JournalArticle-2016.pdf
Adobe PDF, 3.56 MB
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.1155/2016/6756138
Abstract
Generalized pustular psoriasis (GPP) is a severe form of psoriasis that can be caused by missense mutations in the interleukin-36 (IL-36) receptor antagonist. In addition to neutrophil rich skin inflammation, GPP patients typically also experience anorexia, fever, malaise, and pain. The imiquimod-induced skin inflammation mouse model has rapidly become a popular way to study plaque psoriasis, which typically does not involve symptoms of systemic disease. In this model, neutrophil recruitment to the skin is dependent upon the inflammatory mediators IL-1, via its receptor IL-1R1, and IL-36α. Unexpectedly, we observed that mice also exhibited signs of anorexia (weight loss and decreased food intake), general malaise (decreased activity and loss of interest in building nests), and pain (nose bulging and hunched posture). A scoring system allowing quantitative comparisons of test groups was developed. Female mice were found to develop more severe disease than male mice. Furthermore, mice deficient in both IL-1R1 and IL-36α are nearly disease-free, while mice lacking only one of these inflammatory mediators have less severe disease than wild type mice. Hence, the imiquimod-induced skin inflammation mouse model recapitulates not only plaque psoriasis, but also the more severe symptoms, that is, anorexia, malaise, and pain, seen in GPP.
Description
Citation
Pilar Alvarez, Liselotte E. Jensen, "Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner", Mediators of Inflammation, vol. 2016, Article ID 6756138, 10 pages, 2016. https://doi.org/10.1155/2016/6756138
Citation to related work
Hindawi
Has part
Mediators of Inflammation, Vol. 2016
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
Embedded videos