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Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2P
Kuo, Tsun-Yung Lien, Chia En Lin, Yi-Jiun Lin, Meei-Yun Wu, Chung-Chin Tang, Wei-Hsuan Campbell, John D. Traquina, Paula Chuang, Ya-Shan Liu, Luke Tzu-Chi
Kuo, Tsun-Yung
Lien, Chia En
Lin, Yi-Jiun
Lin, Meei-Yun
Wu, Chung-Chin
Tang, Wei-Hsuan
Campbell, John D.
Traquina, Paula
Chuang, Ya-Shan
Liu, Luke Tzu-Chi
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Journal article
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2022-04-22
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Biology
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http://dx.doi.org/10.1093/infdis/jiac153
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern negatively impact the effectiveness of vaccines. In this study, we challenge hamsters with the delta variant after 2- or 3-dose inoculations with SARS-CoV-2 vaccines constructed from stabilized prefusion spike proteins (S-2P) of Wuhan (W) and beta (B) variants. Compared to 3 doses of W S-2P, 2 doses of W S-2P followed by a third dose of B S-2P induced the highest neutralizing antibody titer against live SARS-CoV-2 virus and enhanced neutralization of omicron variant pseudovirus. Reduced lung live virus titer and pathology suggested that all vaccination regimens protect hamsters from SARS-CoV-2 delta variant challenge.
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Tsun-Yung Kuo, Chia En Lien, Yi-Jiun Lin, Meei-Yun Lin, Chung-Chin Wu, Wei-Hsuan Tang, John D Campbell, Paula Traquina, Ya-Shan Chuang, Luke Tzu-Chi Liu, Jinyi Cheng, Charles Chen, Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2P, The Journal of Infectious Diseases, Volume 226, Issue 9, 1 November 2022, Pages 1562–1567, https://doi.org/10.1093/infdis/jiac153
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Oxford University Press (OUP)
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The Journal of Infectious Diseases, Vol. 226, Iss. 9
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