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A protocol for safe lithiation reactions using organolithium reagents
Gau, MR Zdilla, MJ
Gau, MR
Zdilla, MJ
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Journal Article
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2016-11-12
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DOI
10.3791/54705
Abstract
© 2016 Journal of Visualized Experiments. Organolithium reagents are powerful tools in the synthetic chemist's toolbox. However, the extreme pyrophoric nature of the most reactive reagents warrants proper technique, thorough training, and proper personal protective equipment. To aid in the training of researchers using organolithium reagents, a thorough, step-by-step protocol for the safe and effective use of tert-butyllithium on an inert gas line or within a glovebox is described. As a model reaction, preparation of lithium tert-butyl amide by the reaction of tert-butyl amine with one equivalent of tert-butyl lithium is presented.
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