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Aurora A kinase activity influences calcium signaling in kidney cells
Plotnikova, Olga V. Pugacheva, Elena N.
Plotnikova, Olga V.
Pugacheva, Elena N.
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Journal article
Date
2011-06-13
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Cancer and Cellular Biology
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http://dx.doi.org/10.1083/jcb.201012061
Abstract
Most studies of Aurora A (AurA) describe it as a mitotic centrosomal kinase. However, we and others have recently identified AurA functions as diverse as control of ciliary resorption, cell differentiation, and cell polarity control in interphase cells. In these activities, AurA is transiently activated by noncanonical signals, including Ca2+-dependent calmodulin binding. These and other observations suggested that AurA might be involved in pathological conditions, such as polycystic kidney disease (PKD). In this paper, we show that AurA is abundant in normal kidney tissue but is also abnormally expressed and activated in cells lining PKD-associated renal cysts. PKD arises from mutations in the PKD1 or PKD2 genes, encoding polycystins 1 and 2 (PC1 and PC2). AurA binds, phosphorylates, and reduces the activity of PC2, a Ca2+-permeable nonselective cation channel and, thus, limits the amplitude of Ca2+ release from the endoplasmic reticulum. These and other findings suggest AurA may be a relevant new biomarker or target in the therapy of PKD.
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Citation
Plotnikova OV, Pugacheva EN, Golemis EA. Aurora A kinase activity influences calcium signaling in kidney cells. J Cell Biol. 13 June 2011;193(6):1021–1032. doi:10.1083/jcb.201012061.
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Rockefeller University Press
Has part
The Journal of Cell Biology, Vol. 193, No. 6
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