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Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury

Keefe, Kathleen M.
; 
Sheikh, Imran S.
; 
Smith, George M.
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Journal article
Date
2017-03-03
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Committee member
Group
Shriners Hospital Pediatric Research Center, Center for Neural Repair and Rehabilitation (Temple University)
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Subject
Spinal cord injury
 Neurotrophic factors
 Nerve growth factor
 Brain-derived neurotrophic factor
 Neurotrophin-3
 Neuroprotection
 Plasticity
 Regeneration
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http://hdl.handle.net/20.500.12613/8789
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KeefeEtAl-JournalArticle-2017.pdf
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https://doi.org/10.3390/ijms18030548
Abstract
Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and neurotransmitter release, and elicit the plasticity and growth of axons within the adult central and peripheral nervous system. Since the 1950s, these factors have been extensively studied in traumatic injury models. Here we review several members of the classical family of neurotrophins, the receptors they bind to, and their contribution to axonal regeneration and sprouting of sensory and motor pathways after spinal cord injury (SCI). We focus on nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), and their effects on populations of neurons within diverse spinal tracts. Understanding the cellular targets of neurotrophins and the responsiveness of specific neuronal populations will allow for the most efficient treatment strategies in the injured spinal cord.
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Citation
Keefe KM, Sheikh IS, Smith GM. Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury. International Journal of Molecular Sciences. 2017; 18(3):548. https://doi.org/10.3390/ijms18030548
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International Journal of Molecular Sciences, Vol. 18, Iss. 3, Special issue: Neurotrophic Factors - Historical Perspective and New Directions
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