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Gene-Based Therapies for Neurodegenerative Diseases
Shan, Varsha Le, Caitlin My Hanh de Arruda, Thais Costa Macedo Nakahara, Kate Becker, Claire
Shan, Varsha
Le, Caitlin My Hanh
de Arruda, Thais Costa Macedo
Nakahara, Kate
Becker, Claire
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Journal article
Date
2023-05-09
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Psychology and Neuroscience
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http://dx.doi.org/10.34944/dspace/10129
Abstract
While infectious viruses have had devastating effects throughout history, recently developed virus-based biotechnologies have the potential to revolutionize treatment of genetic diseases. Specifically, viruses have been vital in the advancement of gene therapy [1]. Gene-based therapy treats diseases by altering the body at the cellular level with the potential to deliver longer-lasting and more personalized impacts than traditional drug-based therapies, making it an appealing route for “achieving permanent correction” [2],[3]. Gene therapy corrects mutated genes that have undergone alterations in their DNA sequence through the delivery of genetic material into cells [4]. A gene mutation occurs when there is a change in a DNA sequence that causes the sequence to be different from what is expected. Gene mutations can be characterized as hereditary or acquired mutations. Hereditary mutations are inherited from parents, while acquired mutations are created at a particular time in a person’s life [5]. A tool known as a vector can act as a vessel for the genetic material to aid the delivery process [4]. Alongside plasmids and nanostructures, viruses can act as a type of viral vector to improve the efficiency of gene therapy [6]. Given the incurable nature of neurodegenerative diseases, which are characterized by the gradual loss of function and death of nerve cells, gene therapy is quickly emerging as a helpful method for improving their management [7]. This article will investigate the efficacy of applying gene-based therapies to the diagnosis and treatment of neurodegenerative diseases and the methodology available today.
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Citation
Shan, V., Le, C.M.H., de Arruda, T.C.M., Nakahara, K., Becker, C., & Zeid, D. (2023). Gene-Based Therapies for Neurodegenerative Diseases. Grey Matters, 5, 44-47.
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Available at: https://greymattersjournaltu.org/issue-5/gene-based-therapies-for-neurodegenerative-diseases
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Grey Matters, Iss. 5, Spring 2023
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