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miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium
Djalinac, Natasa Kolesnik, Ewald Maechler, Heinrich Scheruebel-Posch, Susanne Pelzmann, Brigitte Rainer, Peter P. Foessl, Ines Scherr, Daniel Heinemann, Akos
Djalinac, Natasa
Kolesnik, Ewald
Maechler, Heinrich
Scheruebel-Posch, Susanne
Pelzmann, Brigitte
Rainer, Peter P.
Foessl, Ines
Scherr, Daniel
Heinemann, Akos
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2022-06-23
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http://dx.doi.org/10.3390/ijms23136962
Abstract
Many cardiac insults causing atrial remodeling are linked to either stretch or tachycardia, but a comparative characterization of their effects on early remodeling events in human myocardium is lacking. Here, we applied isometric stretch or sustained tachycardia at 2.5 Hz in human atrial trabeculae for 6 h followed by microarray gene expression profiling. Among largely independent expression patterns, we found a small common fraction with the microRNA miR-1183 as the highest up-regulated transcript (up to 4-fold). Both, acute stretch and tachycardia induced down-regulation of the predicted miR-1183 target genes ADAM20 and PLA2G7. Furthermore, miR-1183 was also significantly up-regulated in chronically remodeled atrial samples from patients with persistent atrial fibrillation (3-fold up-regulation versus sinus rhythm samples), and in ventricular myocardium from dilative cardiomyopathy hearts (2-fold up-regulation) as compared to non-failing controls. In sum, although stretch and tachycardia show distinct transcriptomic signatures in human atrial myocardium, both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets in acute and chronic remodeling. Thus, elevated expression of miR-1183 might serve as a tissue biomarker for atrial remodeling and might be of potential functional significance in cardiac disease.
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Djalinac, N.; Kolesnik, E.; Maechler, H.; Scheruebel-Posch, S.; Pelzmann, B.; Rainer, P.P.; Foessl, I.; Wallner, M.; Scherr, D.; Heinemann, A.; et al. miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium. Int. J. Mol. Sci. 2022, 23, 6962. https://doi.org/10.3390/ijms23136962
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International Journal of Molecular Sciences, Vol. 23, Iss. 13
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