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Journal article
Date
2022-11-28
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Committee member
Department
Cardiovascular Sciences
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DOI
http://dx.doi.org/10.3390/ijms232314910
Abstract
The two members of the UBASH3/TULA/STS-protein family have been shown to critically regulate cellular processes in multiple biological systems. The regulatory function of TULA-2 (also known as UBASH3B or STS-1) in platelets is one of the best examples of the involvement of UBASH3/TULA/STS proteins in cellular regulation. TULA-2 negatively regulates platelet signaling mediated by ITAM- and hemITAM-containing membrane receptors that are dependent on the protein tyrosine kinase Syk, which currently represents the best-known dephosphorylation target of TULA-2. The biological responses of platelets to collagen and other physiological agonists are significantly downregulated as a result. The protein structure, enzymatic activity and regulatory functions of UBASH3/TULA/STS proteins in the context of platelet responses and their regulation are discussed in this review.
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Citation
Kunapuli, S.P.; Tsygankov, A.Y. TULA-Family Regulators of Platelet Activation. Int. J. Mol. Sci. 2022, 23, 14910. https://doi.org/10.3390/ijms232314910
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International Journal of Molecular Sciences, Vol. 23, Iss. 23
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