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Protein Interaction-Targeted Drug Discovery: Evaluating Critical Issues
Tew, Kenneth D. Dadke, Disha
Tew, Kenneth D.
Dadke, Disha
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Journal article
Date
2002-03
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Cancer and Cellular Biology
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DOI
http://dx.doi.org/10.2144/02323dd01
Abstract
The goal of drug discovery is to develop novel small-molecule compounds that ameliorate, cure, and (optimal-ly) prevent clinically significant diseases. It has been much asserted that the resources of genome and proteome projects will contribute significantly towards this goal. The volume of information generated through these projects is by any objective standard impressive and overwhelming, providing a great impetus to the development of a bioinformatics community that will be able to make sense of the data onslaught (issues discussed in References 12 and 13). From an intellectual perspective, this work has the potential to add a new level of rigorous mathematical modeling to the common conceptions of cell, tissue, and organism over the next decade or so. However, from a pragmatic perspective focused on drug discovery over the window of the next three to five years, an essential topic of debate is how best to garner information from “-omics” resources as they become available and how to exploit this information to generate useful compounds. In this context, one idea has been to develop novel drugs that have improved specificity of action, and reduced undesirable side effects, by targeting specific proteins or protein-protein interactions (PPIs). The purpose of this review is to discuss what such a strategy entails, how screening for such targeted agents might be practically accomplished, and to raise issues concerning the validation of results.
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Citation
Golemis EA, Tew KD, Dadke D. Protein Interaction-Targeted Drug Discovery: Evaluating Critical Issues. BioTechniques. 2002 Mar;32(3):636-647. doi:10.2144/02323dd01.
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Future Science Group
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BioTechniques, Vol. 32, Iss. 3
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