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Default predicted no-effect target concentrations for antibiotics in the absence of data for the protection against antibiotic resistance and environmental toxicity
Vestel, Jessica Tell, Joan Constantine, Lisa A. Häner, Andreas Hellstern, Jutta Journel, Romain Ryan, Jim J. Swenson, Tim Xei, Wei
Vestel, Jessica
Tell, Joan
Constantine, Lisa A.
Häner, Andreas
Hellstern, Jutta
Journel, Romain
Ryan, Jim J.
Swenson, Tim
Xei, Wei
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Journal article
Date
2022-02-21
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Civil and Environmental Engineering
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http://dx.doi.org/10.1002/ieam.4560
Abstract
The pharmaceutical manufacturing industry, via the AMR Industry Alliance, has developed and implemented steps to help minimize the potential impact of pharmaceutical manufacturing on the spread of antimicrobial resistance (AMR). One of these steps was to publish predicted no-effect concentrations (PNECs) to serve as targets for antibiotic manufacturing wastewater effluent risk assessments aimed to help protect environmental receptors and to mitigate against the spread of antibiotic resistance. Concentrations below which adverse effects in the environment are not expected to occur (PNECs) were first published in 2018 and are updated annually. The current list now stands at 125 antibiotics; however, it is recognized that this list does not encompass all manufactured antibiotics. Therefore, a statistical evaluation of currently available data was conducted and a default PNEC of 0.05 µg/L for antibiotics in the absence of other data was derived. Integr Environ Assess Manag 2022;18:863–867. © 2022 Merck, Sanofi, Johnson & Johnson Services, Inc, F.Hoffmann-La Roche Ltd, Teva Pharmaceuticals, GlaxoSmithKline, Novartis Pharma AG, and Pfizer lnc. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
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Vestel, J., Caldwell, D.J., Tell, J., Constantine, L., Häner, A., Hellstern, J., Journel, R., Ryan, J.J., Swenson, T. and Xei, W. (2022), Default predicted no-effect target concentrations for antibiotics in the absence of data for the protection against antibiotic resistance and environmental toxicity. Integr Environ Assess Manag, 18: 863-867. https://doi.org/10.1002/ieam.4560
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Integrated Environmental Assessment and Management (IEAM), Vol. 18, Iss. 4
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