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Clinical Characteristics and Outcomes of COVID-19 Acute Respiratory Distress Syndrome (ARDS) Survivors in Early Pandemic: A Single Healthcare System Retrospective Study
Vahdatpour, Cyrus A. De Young, Sheila Jaber, Johnny F. Ayyoub, Joy Sommers, Thomas Wen, Christopher Lim, Tristan Owoyemi, Olutosin Davin, Kathleen Kinniry, Paul
Vahdatpour, Cyrus A.
De Young, Sheila
Jaber, Johnny F.
Ayyoub, Joy
Sommers, Thomas
Wen, Christopher
Lim, Tristan
Owoyemi, Olutosin
Davin, Kathleen
Kinniry, Paul
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2022-07-13
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http://dx.doi.org/10.7759/cureus.26801
Abstract
Introduction: Acute respiratory distress syndrome (ARDS) management in the intensive care unit (ICU) has attracted strong interest since the start of the COVID-19 pandemic. Our retrospective study aims to describe the outcomes and predictors of mortality of ARDS associated with COVID-19 within one university-based healthcare system. Methods: We identified 165 patients within our healthcare system during the months of April 2020 through July 2020, who were admitted to our medical ICUs and eligible for our study. Baseline patient characteristics, ICU and hospital course information, ICU interventions, ventilator settings, and hospital complications were collected and analyzed using descriptive statistical techniques. Results: Our cohort had an average age of 64. No significant difference in mortality was identified with male vs. female gender or BMI. Most of the patient cohort was identified as black (68.2%). The overall mortality of our cohort was 38.2%. Hyperlipidemia, coronary artery disease, and chronic obstructive pulmonary disease were all associated with higher mortality. There was a significant difference in mortality between those with higher observed ventilator plateau pressures at 24 hours and higher driving pressures at 24 hours. Conclusion: COVID-19-associated ARDS is associated with significant mortality. Physicians should be aware of pre-existing conditions potentially related to worse outcomes so that they receive an appropriate level of care in a timely manner. Ventilator management should focus on maintaining low intra-thoracic pressure changes. Prospective studies are needed to guide COVID-19-associated ARDS management.
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Vahdatpour C A, De Young S, Jaber J F, et al. (July 13, 2022) Clinical Characteristics and Outcomes of COVID-19 Acute Respiratory Distress Syndrome (ARDS) Survivors in Early Pandemic: A Single Healthcare System Retrospective Study. Cureus 14(7): e26801. doi:10.7759/cureus.26801
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Cureus: Journal of Medical Science, Vol. 14
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