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Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection
De Rosa, Alfredo Di Gaudio, Francesca Internicola, Pietro Bettini, Cinzia Salzano, Nicola Castrianni, Davide Marotta, Andrea Boccellino, Mariarosaria
De Rosa, Alfredo
Di Gaudio, Francesca
Internicola, Pietro
Bettini, Cinzia
Salzano, Nicola
Castrianni, Davide
Marotta, Andrea
Boccellino, Mariarosaria
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Journal article
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2021-06-10
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Biology
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https://doi.org/10.3390/ijerph18126310
Abstract
Background and aims: Quick and reliable diagnostic tools play an important role in controlling the spread of the SARS-Cov-2 pandemic. The aim of this study was to evaluate the diagnostic accuracy of a new cyto-salivary antigen test aimed at detecting the presence of antigens for SARS-CoV-2, as compared by the gold standard RT-PCR and a lateral flow test. Methods: A total of 433 healthy volunteers were enrolled in the study and the sensitivity and specificity of the new cyto-salivary antigen test were calculated, as compared to the RT-PCR nasopharyngeal swab and to the lateral flow test. Results: A total of 433 samples were collected and tested at the Mediterranean Fair in Palermo from February 2021 until April 2021. The new cyto-salivary antigen had a sensitivity of 100% and a specificity of 94.2%. The sensitivity and the specificity of the lateral flow test were 55% and 100%, respectively. Conclusions: The new cyto-salivary antigen test detected more positive cases than the RT-PCR in a sample of asymptomatic subjects, demonstrating to be a promising tool for a more sensitive diagnosis of COVID-19. Further studies are warranted to better characterize its diagnostic accuracy.
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Di Domenico, M.; De Rosa, A.; Di Gaudio, F.; Internicola, P.; Bettini, C.; Salzano, N.; Castrianni, D.; Marotta, A.; Boccellino, M. Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection. Int. J. Environ. Res. Public Health 2021, 18, 6310. https://doi.org/10.3390/ijerph18126310
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International Journal of Environmental Research and Public Health, Vol. 18, No. 12
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