Loading...
Impact of pulmonary embolism response teams on acute pulmonary embolism: a systematic review and meta-analysis
Lehr, Andrew L. Lakhther, Vlad Cohen, Gary Panaro, Joseph Maldonado, Thomas S. Horowitz, James
Lehr, Andrew L.
Lakhther, Vlad
Cohen, Gary
Panaro, Joseph
Maldonado, Thomas S.
Horowitz, James
Citations
Altmetric:
Genre
Journal article
Date
2022-07-12
Advisor
Committee member
Group
Department
Thoracic Medicine and Surgery
Radiology
Neural Sciences
Medicine
Radiology
Neural Sciences
Medicine
Subject
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.1183/16000617.0023-2022
Abstract
Background: The impact of pulmonary embolism response teams (PERTs) on treatment choice and outcomes of patients with acute pulmonary embolism (PE) is still uncertain. Objective: To determine the effect of PERTs in the management and outcomes of patients with PE. Methods: PubMed, Embase, Web of Science, CINAHL, WorldWideScience and MedRxiv were searched for original articles reporting PERT patient outcomes from 2009. Data were analysed using a random effects model. Results 16 studies comprising 3827 PERT patients and 3967 controls met inclusion criteria. The PERT group had more patients with intermediate and high-risk PE (66.2%) compared to the control group (48.5%). Meta-analysis demonstrated an increased risk of catheter-directed interventions, systemic thrombolysis and surgical embolectomy (odds ratio (OR) 2.10, 95% confidence interval (CI) 1.74–2.53; p<0.01), similar bleeding complications (OR 1.10, 95% CI 0.88–1.37) and decreased utilisation of inferior vena cava (IVC) filters (OR 0.71, 95% CI 0.58–0.88; p<0.01) in the PERT group. Furthermore, there was a nonsignificant trend towards decreased mortality (OR 0.87, 95% CI 0.71–1.07; p=0.19) with PERTs. Conclusions: The PERT group showed an increased use of advanced therapies and a decreased utilisation of IVC filters. This was not associated with increased bleeding. Despite comprising more severe PE patients, there was a trend towards lower mortality in the PERT group.
Description
Citation
Citation to related work
European Respiratory Society (ERS)
Has part
European Respiratory Review, Vol. 31, No. 165
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu