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Adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) host for programmable surface functionalization

Zhang, Shaohua
; 
Li, Wei
; 
Luan, Jiabin
; ; ; ; 
Sun, Jiawei
; 
Wang, Danni
; 
Teora, Serena P.
; 
Rijpkema, Sjoerd J.
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Journal article
Date
2022-11-21
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Committee member
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Institute for Genomics and Evolutionary Medicine (iGEM) (Temple University)
Institute for Computational Molecular Science (Temple University)
Department
Biology
Physics
Subject
Nanostructures
 Self-assembly
 Supramolecular polymers
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http://hdl.handle.net/20.500.12613/10413
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SrivastavaEtAl-JournalArticle-2022-11.pdf
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http://dx.doi.org/10.1038/s41557-022-01090-0
Abstract
Covalent and non-covalent molecular binding are two strategies to tailor surface properties and functions. However, the lack of responsiveness and requirement for specific binding groups makes spatiotemporal control challenging. Here, we report the adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) (PEG) host as a non-covalent binding strategy for surface functionalization. By using polycyclic aromatic hydrocarbons as the hydrophobic anchor, hydrophilic charged and non-charged functional modules were spontaneously loaded onto PEG corona in 2 min without the assistance of any catalysts and binding groups. The thermodynamically favourable insertion of the hydrophobic anchor can be reversed by pulling the functional module, enabling programmable surface functionalization. We anticipate that the adaptive molecular recognition between the hydrophobic anchor and the PEG host will challenge the hydrophilic understanding of PEG and enhance the progress in nanomedicine, advanced materials and nanotechnology.
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Citation
Zhang, S., Li, W., Luan, J. et al. Adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) host for programmable surface functionalization. Nat. Chem. 15, 240–247 (2023). https://doi.org/10.1038/s41557-022-01090-0
Citation to related work
Nature Research
Has part
Nature Chemistry, Vol. 15
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