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Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design
Speck, Nancy A. Hopkins, Nancy
Speck, Nancy A.
Hopkins, Nancy
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Journal article
Date
1990-02-01
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Department
Cancer and Cellular Biology
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https://doi.org/10.1128/jvi.64.2.534-542.1990
Abstract
We aligned published sequences for the U3 region of 35 type C mammalian retroviruses. The alignment reveals that certain sequence motifs within the U3 region are strikingly conserved. A number of these motifs correspond to previously identified sites. In particular, we found that the enhancer region of most of the viruses examined contains a binding site for leukemia virus factor b, a viral corelike element, the consensus motif for nuclear factor 1, and the glucocorticoid response element. Most viruses containing more than one copy of enhancer sequences include these binding sites in both copies of the repeat. We consider this set of binding sites to constitute a framework for the enhancers of this set of viruses. Other highly conserved motifs in the U3 region include the retrovirus inverted repeat sequence, a negative regulatory element, and the CCAAT and TATA boxes. In addition, we identified two novel motifs in the promoter region that were exceptionally highly conserved but have not been previously described.
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Citation
Golemis EA, Speck NA, Hopkins N. Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design. J Virol. 1990 Feb 1;64(2). doi:10.1128/jvi.64.2.534-542.1990.
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American Society for Microbiology
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Journal of Virology, Vol. 64, Iss. 2
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