TY - JOUR AB - Introduction: We evaluated magnetic resonance spectroscopy (MRS) in United States military personnel with persistent symptoms after mild traumatic brain injury (mTBI), comparing over time two groups randomized to receive hyperbaric oxygen or sham chamber sessions and a third group of normative controls. Methods: Active‐duty or veteran military personnel and normative controls underwent MRS outcome measures at baseline, 13 weeks (mTBI group only), and six months. Participants received 3.0 Tesla brain MRS for analysis of water‐suppressed two‐dimensional (2D) multivoxel 1H‐MRS of the brain using point resolved spectroscopy (PRESS) with volume selection localized above the lateral ventricles and within the brain parenchyma, of which one voxel was chosen in each hemisphere without artifact. Script‐based automatic data processing was used to assess N‐acetylaspartate (NAA), creatine (Cr), and choline (Cho). Metabolite ratios for white matter were then calculated for NAA/Cr (Area), Cho/Cr (Area), and Cho/NAA (Area). These ratios were compared using standard analysis methodology. Results: There were no observable differences between participants with mTBI and normative controls nor any observable changes over time in the NAA/Cr (area), Cho/Cr (area), and Cho/NAA (area) ratios. Similarly, the control and injured participants were indistinguishable. Discussion: While participants with mild TBI showed no difference in MRS compared to normative controls, our results are limited by the few voxels chosen and potentially by less sensitive MRS markers. AN - CN-02002636 KW - *concussion *hyperbaric oxygen therapy *traumatic brain injury Adult Article Artifact Controlled study Human Lateral brain ventricle Outcome assessment Parenchyma Proton nuclear magnetic resonance Soldier Veteran White matter M1 - 3 M3 - Journal: Article N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2019 SP - 291‐297 ST - Analysis of magnetic resonance spectroscopy relative metabolite ratios in mild traumatic brain injury and normative controls T2 - Undersea & hyperbaric medicine TI - Analysis of magnetic resonance spectroscopy relative metabolite ratios in mild traumatic brain injury and normative controls UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-02002636/full VL - 46 ID - 931971 ER - TY - JOUR AB - Safety monitoring and successful blinding are important features of randomized, blinded clinical trials. We report chamber‐ and protocol‐related adverse events (AEs) for participants enrolled in two randomized, double‐blind clinical trials of hyperbaric oxygen (HBO2) for persistent post‐concussive symptoms clinicaltrials.gov identifiers NCT01306968, HOPPS, and NCT01611194, BIMA), as well as the success of maintaining the blind with a low‐pressure sham control arm. In both studies, participants were randomized to receive HBO2 (1.5 atmospheres absolute, >99% oxygen) or sham chamber sessions (1.2 atmospheres absolute, room air). In 143 participants undergoing 4,245 chamber sessions, chamber‐related adverse events were rare (1.1% in the HOPPS study, 2.2% in the BIMA study). Minor, non‐limiting barotrauma was the most frequently reported. Rarely, some participants experienced headache with chamber sessions. No serious adverse events were associated with chamber sessions. An allocation questionnaire completed after intervention revealed that the sham control arm adequately protected the blind in both trials. Participants based allocation assumptions on symptom improvement or lack of symptom improvement and could not discern intervention arm by pressure, smell, taste, or gas flow. AN - CN-02002674 KW - *adverse event *hyperbaric oxygen therapy *postconcussion syndrome *traumatic brain injury Adult Ambient air Article Barotrauma Controlled study Double blind procedure Drug therapy Female Gas flow Headache Human Hypobarism Major clinical study Male Monitoring Odor Questionnaire Randomized controlled trial (topic) Single blind procedure M1 - 3 M3 - Journal: Article N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2019 SP - 331‐340 ST - Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms T2 - Undersea & hyperbaric medicine TI - Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-02002674/full VL - 46 ID - 931981 ER - TY - WEB AB - 857 May 27 4:05 PM - 4:15 PM Beneficial Effects Of Exposure To Mild Hyperbaric Oxygen On Microcirculation In Peripheral Tissues Badur un Nisa1 , Hiroyo Kondo2 , Akihiko Ishihara3 , Fujino Hidemi1 . 1 Kobe University, Kobe, Japan. 2 Nagoya Women’s University, Nagoya, Japan. 3 Kyoto University, Kyoto, Japan. Email: badurunnisa@yahoo.com (No relevant relationships reported) The intent of exposure to mild hyperbaric oxygen (mHBO) is to increase the oxygenation of a person’s blood by forcing additional oxygen to dissolve into the blood plasma. There is a lack of substantial evidence regarding responses of exposure to mHBO on microcirculation in peripheral tissues, and this research will provide insight into it. Purpose: To determine the beneficial effects of exposure to mHBO on microcirculation in peripheral tissues. Methods: In this experimental study 15 healthy individuals were exposed to both normobaric (1.00 ATA with 20.9% oxygen) and mHBO (1.4 ATA, Oxygen Concentration 30.8% - 39.5%) in a mild hyperbaric oxygen chamber for 70 minutes in each condition. Peripheral capillary oxygen saturation (SpO2 ) and blood flow in capillaries of muscles and skin were measured every 15 minutes during both exposures in the supine position. Repeated measures ANOVA and paired t-test were used for statistical comparisons. An analysis with a p-value <0.05 was considered significant. Results: The mean age of participants was 24.6±4.9 years and mean BMI was 20.5±2.7. Average blood flow in capillaries was increased from 94μm/s to 105μm/s after exposure to normobaric condition whereas average blood flow was increased from 92μm/s to 126μm/s after exposure to mHBO. We found a significant effect of conditions (p<.008), time (p<.001) as well as interactional effect (p<.001). SpO2 was increased from 97.6% to 99.5% after exposure to mHBO and it was unchanged after exposure to the normobaric condition. We found a significant effect of conditions (p<.001), time (p<.001) as well as interactional effect (p<.001). Conclusion: The results of this study confirm that exposure to mHBO increases oxygen saturation and blood flow in the capillaries of peripheral tissues. N1 - See Page 162 of ACSM 2020 abstracts PDF PY - 2020 SP - ACSM 2020 San Francisco Abstracts UR - https://www.acsm.org/docs/default-source/annual-meeting-documents/2020-san-francisco-ca/abstract-pdfs/acsm20_abstracts-full-file.pdf?sfvrsn=9374b182_4 ID - 932059 ER - TY - WEB AB - Board #196 May 29 1:30 PM - 3:00 PM Hyperbaric Oxygen Therapy Promotes Muscle Recovery After Contusion Injury Via Angiogenesis By Reactive Nitrogen Species Naoki Yamamoto, Takuya Oyaizu, Kazuyoshi Yagishita, Mitsuhiro Enomoto, Masaki Horie, Toshiyuki Ohara, Mikio Shioda, Ryohei Takada, Atsushi Okawa. Tokyo Medical and Dental University, Tokyo, Japan. Email: yamamoto.orth@tmd.ac.jp (No relevant relationships reported) Background: Muscle contusion is a common sports injury, but delayed return to competition may negatively influence athlete’s careers. Recently, hyperbaric oxygen (HBO) treatment promoted early recovery from muscle injury with reduction of soft tissue swelling. Increased reactive oxygen species (ROS) and reactive nitrogen oxide species (RNS) is a key mechanism of HBO, which supplies abundant oxygen due to increased dissolved oxygen at high pressure, and a high O2 content in tissues. RNS generally stimulate vascular endothelial growth factor (VEGF) secretion from endothelial cells, which then induces angiogenesis. Purpose: To investigate whether HBO could promote angiogenesis with induction of ROS /RNS and induce muscle regeneration after contusion injury in rats. Methods: Muscle contusion was induced by the mass-drop method on the right calf muscle of rats. After the injury, the rats were divided into non-treated (NT) and HBO-treated groups. The HBO protocol consisted of 100% oxygen inhalation at 2.5ATA for 120 minutes once a day for 5 consecutive days. We measured VEGF levels and histologically evaluated blood vessel formation and muscle regeneration in the contused muscles. In a functional analysis, we measured the tensile strength of the calf muscles at the final observation point. We also evaluated the effects of a ROS/RNS inhibitor (NAC) or RNS specific inhibitor (L-NAME) in the HBO group.Results: HBO significantly increased VEGF levels at 3 hours (NT group: 311.2 ± 58.2 pg/ml, HBO group: 827.5 ± 83.8 pg/ml) and promoted blood vessel formation at 3-7 days after contusion (3 days: NT group: 0.04 ± 0.02 /HPF, HBO group: 0.4 ± 0.1 /HPF, 5 days: NT group: 0.82 ± 0.2 /HPF, HBO group: 2.14 ± 0.7 / HPF, 7 days: NT group: 2.8 ± 0.8 /HPF, HBO group: 5.9 ± 0.9 /HPF). Administration of both NAC and L-NAME before HBO suppressed angiogenesis(7 days: NAC + HBO group: 3.4 ± 0.8 /HPF, L-NAME + HBO group: 2.9 ± 0.6 /HPF) and muscle regeneration (NT group: 20.22 ± 2.2 /HPF, HBO group: 34.6 ± 3.2 /HPF, NAC + HBO group: 20.0 ±2.4 /HPF, LNAME + HBO group: 19.4 ±1.5 /HPF) even after HBO. RNS inhibition is more important for the effects of HBO. Conclusions: HBO increased angiogenesis mainly through generation of RNS in the early phase and promoted muscle regeneration after muscle contusion injury. N1 - See page 729 of ACSM 2020 San Francisco conference abstracts PDF PY - 2020 ST - ACSM conference 2020 abstracts TI - ACSM conference 2020 abstracts UR - https://www.acsm.org/docs/default-source/annual-meeting-documents/2020-san-francisco-ca/abstract-pdfs/acsm20_abstracts-full-file.pdf?sfvrsn=9374b182_4 ID - 932060 ER - TY - JOUR DO - 10.4085/1062-6050-50.6.s1 M1 - 6 Supplement PY - 2021 SN - 1062-6050 ST - Supplement T2 - Journal of Athletic Training TI - Supplement UR - https://meridian.allenpress.com/jat/article-pdf/50/6 Supplement/S-1/1455854/1062-6050-50_6_s1.pdf VL - 50 ID - 932058 ER - TY - JOUR AB - Case/Program Description: A 49-year-old man with a prior history of TBI who sustained bilateral globus pallidi injury secondary to accidental carbon monoxide (CO) poisoning. The patient was admitted to ARF with severe hypoarousal, akinetic mutism, delayed responsiveness, and Parkinson-like rigidity, bradykinesia, shuffling gait. Medications were introduced one at a time and followed by objective measures to assess efficacy. Trazodone was used to normalize sleepwake cycles, zolpidem for paradoxical wakening, amantadine for brain recovery and arousal, methylphenidate for attention, and donepezil for declarative memory. Setting: Acute Rehabilitation Facility (ARF). Results: Trazodone resulted in improved sleep quality and duration. Zolpidem trials were inconclusive as the patient's arousal fluctuated independently of zolpidem administration. It was discontinued as it did not improve cognitive performance. Amantadine appeared to improve wakefulness, social interaction, facial expression, and complexity of sentence structure. These findings were corroborated by improvements in cognitive testing. The patient was able to return to work doing electronic inventory and logistics planning roughly three months after injury. Discussion: While hyperbaric oxygen therapy (HBOT) is strongly recommended for the acute phase of CO poisoning, there is no consensus for the subacute treatment of the ensuing neuropsychiatric sequelae. Methodical step-wise pharmacologic intervention with amantadine, methylphenidate, and donepezil may have facilitated a patient's return to work three months after anoxic CO induced brain injury. Conclusions: Patients suffering from the neurologic sequelae of CO poisoning may gain vast functional improvement from acute HBOT followed by targeted pharmacologic intervention in the subacute phase. AD - J.T. Aida, Loma Linda University, Loma Linda, CA, United States AU - Aida, J. T. AU - Tran, D. A. DB - Embase KW - adenosine diphosphate ribosylation factor amantadine carbon monoxide donepezil endogenous compound methylphenidate trazodone zolpidem adult adverse drug reaction akinetic mutism arousal attention bradykinesia brain injury carbon monoxide intoxication case report clinical trial comparative effectiveness consensus development declarative memory facial expression human hyperbaric oxygen therapy male middle aged neurological complication Parkinson disease rehabilitation return to work rigidity shuffling gait side effect sleep quality social interaction wakefulness LA - English M1 - 9 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1934-1482 SP - S243 ST - A three month journey from the ICU to return to work following carbon monoxide poisoning: A case report T2 - PM and R TI - A three month journey from the ICU to return to work following carbon monoxide poisoning: A case report UR - https://www.embase.com/search/results?subaction=viewrecord&id=L612984200&from=export VL - 8 ID - 931928 ER - TY - JOUR AU - Beam, Joel W. AU - Clinical AU - Applied Movement Sciences, Brooks College of Health University of North Florida Jacksonville AU - Buckley, Bernadette AU - Clinical AU - Applied Movement Sciences, Brooks College of Health University of North Florida Jacksonville AU - Holcomb, William R. AU - School of Kinesiology, University of Southern Mississippi Hattiesburg AU - Ciocca, Mario AU - Department of Sports Medicine, University of North Carolina at Chapel Hill DO - 10.4085/1062-6050-51.7.01 M1 - 12 PY - 2021 SN - 1062-6050 SP - 1053-1070 ST - National Athletic Trainers' Association Position Statement: Management of Acute Skin Trauma T2 - Journal of Athletic Training TI - National Athletic Trainers' Association Position Statement: Management of Acute Skin Trauma UR - https://meridian.allenpress.com/jat/article-pdf/51/12/1053/2277075/1062-6050-51_7_01.pdf VL - 51 ID - 932057 ER - TY - JOUR AB - Introduction: Type 2 diabetes (T2D) is a risk factor for dementia. Ischemia due to vascular pathology is hypothesized to be an underlying mechanism for this association. Hyperbaric oxygen therapy (HBOT) is a treatment in which oxygen-enriched air (up to 100%) is administered to patients in a chamber at a pressure above one atmosphere absolute. HBOT is approved for the treatment of T2D ischemic non-healing wounds. Evidence from animal studies and small clinical trials suggests that HBOT improves hypoxic/ischemic brain injuries, consequently inducing brain angiogensis, leading to cognitive improvement. Methods: We present the design of the first double-blind, placebo-controlled, clinical trial on brain and cognitive outcomes in elderly (n = 154) with T2D and mild cognitive impairment to compare the effects of HBOT versus sham (normal air with 1.1 ATA pressure in the first and last 5 minutes of the session). Eligible candidates are randomized with equal probability to HBOT and sham. Outcomes are assessed before and after treatment, and at 6- and 12-month follow-up. The primary cognitive outcome is global cognitive change, indexed by a composite sum of z-scores of four executive functions and four episodic memory tests. The primary neurobiological outcome is cerebral blood flow (CBF; via arterial spin labeling magnetic resonance imaging [ASL-MRI]) and cerebral glucose utilization via fluorodeoxyglucose positron emission tomography (FDG-PET). Secondary outcome measures are specific cognitive domains (executive function and episodic memory) and functional measures (Clinical Dementia Rating sum of boxes, activities of daily living). Efficacy analyses will be performed for the intent-to-treat sample. Discussion: Recent studies suggest that HBOT induces neuroplasticity and improves cognition in post-stroke and traumatic brain injury patients. However, its effect on cognition, cerebral blood flow, and brain glucose utilization in T2D patients at high dementia risk is yet to be determined. If effective, this study may provide strong evidence for the brain and cognitive benefits of HBOT in this population. AD - M. Schnaider Beeri, The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel M. Schnaider Beeri, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States AU - BenAri, O. AU - Efrati, S. AU - Hadanny, A. AU - Sano, M. AU - Bendlin, B. B. AU - Lin, H. AU - Liu, X. AU - Sela, I. AU - Almog, G. AU - Livny, A. AU - Sandler, I. AU - Ben-Haim, S. AU - Sagi, R. AU - LeRoith, D. AU - Schnaider Beeri, M. AU - Ravona-Springer, R. DB - Embase DO - 10.1002/trc2.12008 KW - nuclear magnetic resonance scanner fluorodeoxyglucose f 18 glucose aged arterial spin labeling article Beck Depression Inventory brain blood flow Clinical Dementia Rating cognition controlled study dementia double blind procedure episodic memory executive function executive function test female follow up functional assessment glucose brain level glucose metabolism glucose utilization human hyperbaric oxygen therapy image processing intention to treat analysis major clinical study male mild cognitive impairment Mini Mental State Examination National Institutes of Health Stroke Scale neuroimaging non insulin dependent diabetes mellitus nuclear magnetic resonance imaging positron emission tomography priority journal randomized controlled trial spin labeling stroke patient treatment outcome LA - English M1 - 1 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2020 SN - 2352-8737 ST - A double-blind placebo-controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design T2 - Alzheimer's and Dementia: Translational Research and Clinical Interventions TI - A double-blind placebo-controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design UR - https://www.embase.com/search/results?subaction=viewrecord&id=L2007254767&from=export http://dx.doi.org/10.1002/trc2.12008 VL - 6 ID - 931886 ER - TY - JOUR AB - INTRODUCTION: Type 2 diabetes (T2D) is a risk factor for dementia. Ischemia due to vascular pathology is hypothesized to be an underlying mechanism for this association. Hyperbaric oxygen therapy (HBOT) is a treatment in which oxygen-enriched air (up to 100%) is administered to patients in a chamber at a pressure above one atmosphere absolute. HBOT is approved for the treatment of T2D ischemic non-healing wounds. Evidence from animal studies and small clinical trials suggests that HBOT improves hypoxic/ischemic brain injuries, consequently inducing brain angiogensis, leading to cognitive improvement. METHODS: We present the design of the first double-blind, placebo-controlled, clinical trial on brain and cognitive outcomes in elderly (n = 154) with T2D and mild cognitive impairment to compare the effects of HBOT versus sham (normal air with 1.1 ATA pressure in the first and last 5 minutes of the session). Eligible candidates are randomized with equal probability to HBOT and sham. Outcomes are assessed before and after treatment, and at 6- and 12-month follow-up. The primary cognitive outcome is global cognitive change, indexed by a composite sum of z-scores of four executive functions and four episodic memory tests. The primary neurobiological outcome is cerebral blood flow (CBF; via arterial spin labeling magnetic resonance imaging [ASL-MRI]) and cerebral glucose utilization via fluorodeoxyglucose positron emission tomography (FDG-PET). Secondary outcome measures are specific cognitive domains (executive function and episodic memory) and functional measures (Clinical Dementia Rating sum of boxes, activities of daily living). Efficacy analyses will be performed for the intent-to-treat sample. DISCUSSION: Recent studies suggest that HBOT induces neuroplasticity and improves cognition in post-stroke and traumatic brain injury patients. However, its effect on cognition, cerebral blood flow, and brain glucose utilization in T2D patients at high dementia risk is yet to be determined. If effective, this study may provide strong evidence for the brain and cognitive benefits of HBOT in this population. AD - The Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Ramat-Gan Israel. Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel. Sagol center for Hyperbaric Medicine & Research Shamir (Assaf Harofeh) Medical Center Be'er Ya'akov Israel. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA. Wisconsin Alzheimer's Disease Research Center University of Wisconsin-Madison School of Medicine and Public Health Madison Wisconsin USA. Division of Diagnostic Imaging Sheba Medical Center Tel-Hashomer Ramat-Gan Israel. Department of Nuclear Medicine Sheba Medical Center Tel-Hashomer Ramat-Gan Israel. Department of Biophysics and Nuclear Medicine Hadassah University Hospital Ein Kerem Jerusalem Israel. Institute of Nuclear Medicine University College London Hospitals NHS Trust London UK. Department of Psychiatry Sheba Medical Center Tel-Hashomer Ramat-Gan Israel. AN - 32296731 AU - BenAri, O. AU - Efrati, S. AU - Sano, M. AU - Bendlin, B. B. AU - Lin, H. AU - Liu, X. AU - Sela, I. AU - Almog, G. AU - Livny, A. AU - Sandler, I. AU - Ben-Haim, S. AU - Sagi, R. AU - LeRoith, D. AU - Schnaider Beeri, M. AU - Ravona-Springer, R. C2 - Pmc7153432 DO - 10.1002/trc2.12008 DP - NLM ET - 2020/04/17 J2 - Alzheimer's & dementia (New York, N. Y.) KW - dementia hyperbaric oxygen therapy mild cognitive impairment type 2 diabetes LA - eng M1 - 1 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2020 SN - 2352-8737 SP - e12008 ST - A double-blind placebo-controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design T2 - Alzheimers Dement (N Y) TI - A double-blind placebo-controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design VL - 6 ID - 931844 ER - TY - JOUR AB - The placebo in medicine has a long and interesting history. Despite the widespread use of placebo medication and sham interventions in clinical research, surprisingly little is known about how placebos work. There is evidence the administration of placebo preparations can induce measurable changes in physiology including the production of endorphins. Placebos usually involve some form of deception, but have been shown to work even when their lack of ‘active’ ingredients is declared to the patient. The relevance of the nature of placebo effects has become a central debate in the field of hyperbaric medicine with the recent suggestion that 131 kPa of air may be an active therapeutic intervention rather than a convenient and convincing sham. This paper discusses the nature of placebo and participation effects and the implications for hyperbaric oxygen therapy if low-pressure air is regarded as therapeutic. AD - M.H. Bennett, Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Barker St, Randwick, NSW, Australia AU - Bennett, M. H. DB - Embase Medline KW - naloxone article clinical effectiveness clinical research diving environmental change general practitioner health care planning human hyperbaric oxygen therapy inflammation intervention study medical literature neurologic examination outcome assessment traumatic brain injury LA - English M1 - 4 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2014 SN - 1833-3516 SP - 235-240 ST - Hyperbaric medicine and the placebo effect T2 - Diving and Hyperbaric Medicine TI - Hyperbaric medicine and the placebo effect UR - https://www.embase.com/search/results?subaction=viewrecord&id=L610952354&from=export VL - 44 ID - 931950 ER - TY - JOUR AB - This report is a product of the VA Evidence-based Synthesis Program. The purpose is to provide "timely and accurate syntheses of targeted healthcare topics …. to improve the health and healthcare of Veterans". The authors have made a comprehensive search and analysis of the literature and make recommendations to assist clinicians in dealing with veterans suffering from either traumatic brain injury (TBI) or post-traumatic stress disorder (PTSD). The report is timely and of great potential impact given the vigorous and lengthy debate among hyperbaric physicians and lay people determined to find an answer for the large numbers of veterans deeply affected with some combination of PTSD and post-concussion dysfunction. The authors lament the evidence on using hyperbaric oxygen treatment (HBOT) for TBI/PTSD has been "controversial, widely debated, and potentially confusing." Unfortunately, this report will not improve that situation. The report is as much a political document as it is evidence-based. That politics are involved is apparent from the outset with the statement "The ESP Coordinating Center is responding to a request from the Center for Compassionate Innovation (CCI)…" The report fails to further illuminate the situation than the many thousands of words already spent on summarising the evidence. Let me save you some time and get to the quick of this report. The authors (rightly) highlight the fact that uncontrolled case series and a randomised, controlled trial (RCT) without blinding or a sham control all suggest HBOT may be of benefit for these Veterans. Somewhat disappointingly, well-controlled, blinded RCTs using a sham exposure to 1.2 or 1.3 ATA breathing air fail to confirm any such benefit. While the conventional interpretation of these data is that there is no reliable evidence of an effect of HBOT, proponents have responded by postulating these control exposures are not 'sham' because they are clinically active. Any putative mechanism remains unknown and unproven outside the context of this clinical area. These exposures just happen to be about equipotent with true HBOT. With this accurate summary, the authors conclude that any effect of HBOT is as yet unclear. They suggest that in Veterans who have not responded to other therapeutic options, the use of HBOT is "reasonable". This conclusion allows for a similar recommendation for any unproven therapeutic option where there is no clearly effective treatment available and is, to this reviewer, unacceptable. While any putative mechanism for low-pressure air exposure owes more to magical thinking than physics, physiology or therapeutics, this is an argument the authors of this report seem to have accepted at some level. The proponents of HBOT have an obligation to both show the greater effectiveness of HBOT than a functional sham and to demonstrate a plausible mechanism. Until then, the strongest recommendation that should be made is that the 'sham' therapy can be used until the case is proven. It is not clear why the proponents of HBOT do not advocate this, given the 'efficacy' seems roughly equal with HBOT. Logic determines one cannot prove a negative. This reviewer agrees it is not possible to definitively prove trivial pressure exposures breathing air may have a comparable effectiveness in treating TBI/PTSD as true HBOT. Using the principle of Occam's razor it seems far more likely any apparent effectiveness is the result of a participation effect in both groups. In my view, the authors of this report have taken an easy option in allowing that HBOT use is reasonable. The tragedy is potentially the waste of time, money and hope this may bring to the very Veterans the authors are charged to serve. I have discussed this issue in more detail previously in the pages of this journal. AD - Corresponding author: University of New South Wales, Sydney, Australia. m.bennett@unsw.edu.au. AN - 29888387 AU - Bennett, M. H. DA - Jun 30 DO - 10.28920/dhm48.2.115 DP - NLM ET - 2018/06/12 J2 - Diving and hyperbaric medicine KW - *Brain Injuries, Traumatic/therapy Humans *Hyperbaric Oxygenation Oxygen Inhalation Therapy/*methods *Stress Disorders, Post-Traumatic/therapy Treatment Outcome Central nervous system Hyperbaric research Medical condition and problems Outcome LA - eng M1 - 2 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2018 SN - 1833-3516 (Print) 1833-3516 SP - 115 ST - Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and/or post-traumatic stress disorder T2 - Diving Hyperb Med TI - Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and/or post-traumatic stress disorder VL - 48 ID - 931838 ER - TY - JOUR AB - Hyperbaric oxygen therapy has been proposed as a method to treat traumatic brain injuries. The combination of pressure and increased oxygen concentration produces a higher content of dissolved oxygen in the bloodstream, which could generate a therapeutic benefit for brain injuries. This dissolved oxygen penetrates deeper into damaged brain tissue than otherwise possible and promotes healing. The result includes improved cognitive functioning and an alleviation of symptoms. However, randomized controlled trials have failed to produce consistent conclusions across multiple studies. There are numerous explanations that might account for the mixed evidence, although one possibility is that prior evidence focuses primarily on statistical significance. The current analyses explored existing evidence by calculating an effect size from each active treatment group and each control group among previous studies. An effect size measure offers several advantages when comparing across studies, as it can be used to directly contrast evidence from different scales, and it provides a proximal measure of clinical significance. When exploring the therapeutic benefit through effect sizes, there was a robust and consistent benefit to individuals who underwent hyperbaric oxygen therapy. Placebo effects from the control condition could account for approximately one-third of the observed benefits, but there appeared to be a clinically significant benefit to using hyperbaric oxygen therapy as a treatment intervention for traumatic brain injuries. This evidence highlights the need for design improvements when exploring interventions for traumatic brain injury and the importance of focusing on clinical significance in addition to statistical significance. AD - Naval Special Warfare Command, Coronado, California. Naval Special Warfare Group FOUR, Virginia Beach, Virginia. AN - 33792399 AU - Biggs, A. T. AU - Dainer, H. M. AU - Littlejohn, L. F. DA - May 1 DO - 10.1152/japplphysiol.01084.2020 DP - NLM ET - 2021/04/02 J2 - Journal of applied physiology (Bethesda, Md. : 1985) KW - Tbi effect size hyperbaric oxygen therapy mTBI placebo LA - eng M1 - 5 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2021 SN - 0161-7567 SP - 1594-1603 ST - Effect sizes for symptomatic and cognitive improvements in traumatic brain injury following hyperbaric oxygen therapy T2 - J Appl Physiol (1985) TI - Effect sizes for symptomatic and cognitive improvements in traumatic brain injury following hyperbaric oxygen therapy VL - 130 ID - 931873 ER - TY - JOUR AB - INTRODUCTION: Hyperbaric oxygen therapy (HBOT) is a commonly used treatment for a variety of medical issues, including more than a dozen currently approved uses. However, there are alternative proposed uses that have significant implications among an active duty military or veteran population as treatments for PTSD, mild traumatic brain injury (mTBI), and traumatic brain injury (TBI). These applications have seen a recent groundswell of support from the operator and veteran communities, raising the visibility of using HBOT for alternative applications. The current review will cover the existing evidence regarding alternative uses of HBOT in military medicine and provide several possibilities to explain the potential conflicting evidence from empirical results. MATERIALS AND METHODS: There were no inclusion or exclusion criteria for articles addressing currently approved HBOT uses as covered under the military health system. These references were provided for comparison and illustration as needed. For alternative HBOT uses, the review focuses explicitly upon three alternative uses in PTSD, mTBI, and TBI. The review addresses any piece of case study evidence, observational data, quasi-experimental design, or randomized-controlled trial that explored any or a combination of these issues within an active duty population, a veteran population, or a civilian population. RESULTS: The existing medical evidence does not support a consensus viewpoint for these alternative uses of HBOT. Based on the literature review, there are four competing positions to explain the lack of consistency among the empirical results. These possibilities are described in no particular order. First, an explanation suggests that the results are because of placebo effects. The combination of participant expectations and subjective symptom reporting creates the potential that reported improvements are because of placebo rather than casual mechanisms. Second, another position suggests that experiments have utilized sham conditions which induced therapeutic benefits. If sham conditions have actually been weakened active treatment conditions, rather than placebo controls, it could explain the lack of observed significant differences in randomized clinical trials. Third, there has been a substantial amount of heterogeneity both in the symptoms treated and the treatments applied. This heterogeneity could explain the inconsistency of the data and the difficulty in reaching a consensus viewpoint. Fourth, the HBOT treatments may actively treat some tangential medical issue the patient is having. The treatment would thus promote an environment of healing without directly treating either PTSD, mTBI, or TBI, and the reduction in orthogonal medical issues facilitates a pathway to recovery by reducing tangential medical problems. CONCLUSIONS: The mixed empirical evidence does not support recommending HBOT as a primary treatment for PTSD, mTBI, or TBI. If applied under the supervision of a licensed military medical professional, the consistently safe track record of HBOT should allow it to be considered as an alternative treatment for PTSD, mTBI, or TBI once primary treatment methods have failed to produce a benefit. However, the evidence does warrant further clinical investigation with particular emphasis on randomized clinical trials, better placebo controls, and a need to develop a consistent treatment protocol. AD - Naval Special Warfare Command, Medical Department, Coronado, CA 92155, USA. Naval Special Warfare Group FOUR Medical Department, Virginia Beach, VA 23521, USA. AN - 33564849 AU - Biggs, A. T. AU - Littlejohn, L. F. AU - Dainer, H. M. DA - Feb 10 DO - 10.1093/milmed/usab022 DP - NLM ET - 2021/02/11 J2 - Military medicine LA - eng N1 - PubMed (NLM) literature search June 18, 2021 PY - 2021 SN - 0026-4075 ST - Alternative Uses of Hyperbaric Oxygen Therapy in Military Medicine: Current Positions and Future Directions T2 - Mil Med TI - Alternative Uses of Hyperbaric Oxygen Therapy in Military Medicine: Current Positions and Future Directions ID - 931875 ER - TY - JOUR AB - Background: Anecdotes and small case series have suggested symptomatic improvement from hyperbaric oxygen (HBO2) for military members suffering from persistent post-concussion symptoms. Dose, duration and attribution of the improvement to the HBO2 were relatively unknown due to the lack of randomized trials. As such, a Phase II trial was conducted, which evaluated HBO2 as an adjunct to standard traumatic brain injury (TBI) care in a military population still symptomatic from deployment-related concussion at least 4 months after their most recent injury. Method: The trial was conducted at four military hospitals located near major troop centres. Seventy-two active duty service members were randomized into one of three arms: routine TBI care, TBI care plus sham daily, or TBI care plus HBO2 daily. The dose ofHBO2 selected was 100% O2 at 1.5 atmospheres absolute (ATA) administered for 60 minutes per session, given for 40 sessions within a 10-week period. The sham received roomair at 1.2 ATA while in the chamber. Primary outcome measures were self-reported post-concussive symptom scores at baseline, after 20 sessions, and at the end of the intervention. Results: Neuropsychometric testing and questionnaires assessing post-traumatic stress disorder symptoms, sleep, health-related quality of life, and satisfaction with life were also administered at these time points. Initial findings, which have been widely reported, suggested no difference between the HBO2 group and the sham group on the primary measure of post-concussive symptoms (p = .70). Full neuropsychological results, both standard and computerized, have yet to be reported. Analyses are being conducted, and data will be presented at this meeting. AD - L. Brenner, University of Colorado, Aurora, CO, United States AU - Brenner, L. AU - Bahraini, N. AU - Forster, J. DB - Embase DO - 10.1080/02699052.2017.1312145 KW - oxygen army atmosphere clinical trial controlled clinical trial controlled study hospital human hyperbaric oxygen therapy multicenter study phase 2 clinical trial postconcussion syndrome posttraumatic stress disorder quality of life questionnaire randomized controlled trial satisfaction sleep traumatic brain injury LA - English M1 - 6-7 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 1362-301X SP - 805 ST - Neuropsychological outcomes from a Phase II, randomized, sham-controlled trial hyperbaric oxygen for post-concussion syndrome T2 - Brain Injury TI - Neuropsychological outcomes from a Phase II, randomized, sham-controlled trial hyperbaric oxygen for post-concussion syndrome UR - https://www.embase.com/search/results?subaction=viewrecord&id=L617352949&from=export http://dx.doi.org/10.1080/02699052.2017.1312145 VL - 31 ID - 931919 ER - TY - JOUR AB - Objectives: Due to innovations in body armour and advances in trauma medicine, military personnel serving in Iraq and Afghanistan are surviving injuries that in previous conflicts would have been fatal. Among the injuries being sustained by current service members, traumatic brain injury (TBI) has become recognized as a 'signature' wound. Individuals who sustain mTBI may experience a range of post‐concussive symptoms (PCS), including headaches, dizziness, fatigue, problems concentrating and remembering, irritability, difficulties managing stress and sensory deficits. While for most individuals, these symptoms resolve within 3 months post‐injury, a sub‐set of service members continue to endorse PCS long after the injury event. Treatments targeting multiple PC symptoms are limited. Based on previous work for neurological conditions, interest emerged in hyperbaric oxygen (HBO) as a treatment for chronic PCS. However, the efficacy of HBO as a supplemental treatment for PCS has not been rigorously evaluated. Methods: This was a multi‐centre double‐blind randomized trial of 72 active duty US Service Members with persistent symptoms at least 4 months after deployment‐related mild traumatic brain injury. Participants, all of whom were receiving routine care for PCS, were randomized to either 40 HBO sessions administered at 1.5 atmospheres absolute (ATA), 40 sham sessions of room air at 1.2 ATA or no supplemental chamber sessions. The primary outcome measure was the Rivermead Post‐Concussion Symptoms Questionnaire. Secondary measures included other patient reported outcomes (i.e. the SF‐36 and the PTSD Checklist [PCL]) and the Automated Neuropsychological Assessment Metrics (ANAM). Results: The chamber sessions were well tolerated. Compared to the routine mTBI care group, both groups undergoing chamber procedures showed improvement in symptoms on the RPQ (mean change score = 5.4; 95% CI = ‐0.5 to 11.3; p = 0.008 in the HBO group and 7.0; 95% CI = 1.0‐12.9; p = 0.02 in the sham group). No difference between the HBO and sham group were observed on the RPQ (p = 0.70) or on secondary outcomes of PTSD symptoms, depression, anxiety, sleep, health‐related quality‐of‐life or neurocognitive testing. Conclusions: Data showed there were no additional short‐term benefits to the participants who received hyperbaric oxygen compared to those who received pressured oxygen. Both intervention groups showed improvements in some symptoms compared to those who received routine care alone. Improvements were most likely due to participant expectations coupled with intensive involvement with the research team as part of the chamber procedures. AN - CN-01304317 AU - Brenner, L. AU - Bahraini, N. AU - Weaver, L. AU - Churchill, S. AU - Price, R. AU - Skiba, V. AU - Caviness, J. AU - Mooney, S. AU - Hetzell, B. AU - Liu, J. AU - et al. DO - 10.3109/02699052.2016.1162060 KW - *Short Form 36 *depression *hyperbaric oxygen therapy *military service *postconcussion syndrome *visually impaired person Ambient air Anxiety Atmosphere Case report Checklist Clinical trial Controlled clinical trial Controlled study Double blind procedure Drug combination Expectation Human Patient‐reported outcome Posttraumatic stress disorder Questionnaire Randomized controlled trial Sleep Traumatic brain injury M1 - 5‐6 M3 - Journal: Conference Abstract N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2016 SP - 729‐ ST - Effects of hyperbaric oxygen on symptoms and quality-of-life among US Military service members with persistent post-concussion symptoms: a randomized, double-blind, sham-controlled trial T2 - Brain injury TI - Effects of hyperbaric oxygen on symptoms and quality-of-life among US Military service members with persistent post-concussion symptoms: a randomized, double-blind, sham-controlled trial UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01304317/full VL - 30 ID - 931980 ER - TY - JOUR AB - Objectives: Due to innovations in body armour and advances in trauma medicine, military personnel serving in Iraq and Afghanistan are surviving injuries that in previous conflicts would have been fatal. Among the injuries being sustained by current service members, traumatic brain injury (TBI) has become recognized as a 'signature' wound. Individuals who sustain mTBI may experience a range of post-concussive symptoms (PCS), including headaches, dizziness, fatigue, problems concentrating and remembering, irritability, difficulties managing stress and sensory deficits. While for most individuals, these symptoms resolve within 3 months post-injury, a sub-set of service members continue to endorse PCS long after the injury event. Treatments targeting multiple PC symptoms are limited. Based on previous work for neurological conditions, interest emerged in hyperbaric oxygen (HBO) as a treatment for chronic PCS. However, the efficacy of HBO as a supplemental treatment for PCS has not been rigorously evaluated. Methods: This was a multi-centre double-blind randomized trial of 72 active duty US Service Members with persistent symptoms at least 4 months after deployment-related mild traumatic brain injury. Participants, all of whom were receiving routine care for PCS, were randomized to either 40 HBO sessions administered at 1.5 atmospheres absolute (ATA), 40 sham sessions of room air at 1.2 ATA or no supplemental chamber sessions. The primary outcome measure was the Rivermead Post-Concussion Symptoms Questionnaire. Secondary measures included other patient reported outcomes (i.e. the SF-36 and the PTSD Checklist [PCL]) and the Automated Neuropsychological Assessment Metrics (ANAM). Results: The chamber sessions were well tolerated. Compared to the routine mTBI care group, both groups undergoing chamber procedures showed improvement in symptoms on the RPQ (mean change score = 5.4; 95% CI = -0.5 to 11.3; p = 0.008 in the HBO group and 7.0; 95% CI = 1.0-12.9; p = 0.02 in the sham group). No difference between the HBO and sham group were observed on the RPQ (p = 0.70) or on secondary outcomes of PTSD symptoms, depression, anxiety, sleep, health-related quality-of-life or neurocognitive testing. Conclusions: Data showed there were no additional short-term benefits to the participants who received hyperbaric oxygen compared to those who received pressured oxygen. Both intervention groups showed improvements in some symptoms compared to those who received routine care alone. Improvements were most likely due to participant expectations coupled with intensive involvement with the research team as part of the chamber procedures. AD - L. Brenner, Rocky Mountain MIRECC, Denver, CO, United States AU - Brenner, L. AU - Bahraini, N. AU - Weaver, L. AU - Churchill, S. AU - Price, R. AU - Skiba, V. AU - Caviness, J. AU - Mooney, S. AU - Hetzell, B. AU - Liu, J. AU - Thieling, S. AU - Deru, K. AU - Ricciardi, R. AU - Francisco, S. AU - Close, N. AU - Miller, R. DB - Embase DO - 10.3109/02699052.2016.1162060 KW - oxygen ambient air anxiety atmosphere case report checklist clinical trial controlled clinical trial controlled study depression double blind procedure drug combination expectation human hyperbaric oxygen therapy military service patient-reported outcome postconcussion syndrome posttraumatic stress disorder questionnaire randomized controlled trial Short Form 36 sleep traumatic brain injury visually impaired person LA - English M1 - 5-6 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1362-301X SP - 729 ST - Effects of hyperbaric oxygen on symptoms and quality-of-life among US Military service members with persistent post-concussion symptoms: A randomized, double-blind, sham-controlled trial T2 - Brain Injury TI - Effects of hyperbaric oxygen on symptoms and quality-of-life among US Military service members with persistent post-concussion symptoms: A randomized, double-blind, sham-controlled trial UR - https://www.embase.com/search/results?subaction=viewrecord&id=L614042574&from=export http://dx.doi.org/10.3109/02699052.2016.1162060 VL - 30 ID - 931948 ER - TY - JOUR AB - High-fidelity simulation (SIM) is used in education and training, but evidence on its utility in preparing for clinical research is limited. We describe the process of implementing a required SIM program prior to onboarding study sites to a large, multicenter research trial. The HOBIT trial is investigating the efficacy of hyperbaric oxygen (HBO) therapy for severe traumatic brain injuries. Due to the number of patient care areas involved and the complexity of interdisciplinary care, the process is fraught with Latent Risk Threats (LRTs), or system elements that make individual errors more likely, including processes, policies, and equipment issues. To mitigate these factors, we utilized SIM training to identify potential LRTs prior to allowing study sites to actively enroll. The HOBIT trial investigators met in February 2018. Four training videos depicting the enrollment of a simulated patient as well as three complications were shown. The chosen complications were felt to represent the most likely potential LRTs, including a complication during patient transport where the ventilator circuit kinked; a tension pneumothorax during HBO therapy; and a ventilator disconnection during HBO therapy requiring emergent decompression. LRTs identified during the filming of the scenarios at the primary site included misunderstanding enrollment protocols, clarifying critical care in hyperbarics, inadequate equipment availability, staff scheduling, and questioning emergency operating procedures. After reviewing the four simulated scenarios, a rich discussion ensued regarding both the scripted and additional LRTs discovered at the site, how to proactively avoid these LRTs, potential barriers to implementation at each site, and potential solutions. Prior to beginning active enrollment, investigators were required to return to their individual study sites and record two SIM scenarios- a protocolized patient enrollment across multiple care areas and one complication- along with a list of identified LRTs and their solutions. Based on LRTs identified at the primary site, we predict that the SIM scenarios at participating sites will improve the study enrollment, protocol adherence, and identify LRTs that could impact patient safety. Required SIM of patient enrollment and potential complications is a safe, effective, and readily available technique for identification of LRTs prior to starting large, multicenter clinical trials. AD - L.A. Brown, Interdisciplinary Simulation Education Center, Hennepin County Medical Center, Minneapolis, MN, United States AU - Brown, L. A. DB - Embase DO - 10.1089/neu.2018.29013.abstracts KW - adult case report clinical article complication concussion conference abstract decompression drug safety emergency error female human hyperbaric oxygen therapy intensive care intracranial pressure male multicenter study neuroprotection patient care patient safety patient transport protocol compliance simulation training staff tension pneumothorax traumatic brain injury ventilator videorecording LA - English M1 - 16 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2018 SN - 1557-9042 SP - A73 ST - Required high-fidelity simulation for onboarding of study sites to the hyperbaric oxygen brain injury treatment (HOBIT) trial T2 - Journal of Neurotrauma TI - Required high-fidelity simulation for onboarding of study sites to the hyperbaric oxygen brain injury treatment (HOBIT) trial UR - https://www.embase.com/search/results?subaction=viewrecord&id=L623884497&from=export http://dx.doi.org/10.1089/neu.2018.29013.abstracts VL - 35 ID - 931907 ER - TY - JOUR AB - The presentation has two parts: Part 1: The Brain Injury Recovery Team Model-An Interdisciplinary Approach to Neurotrauma Rehabilitation Part 2: Neuroplastic Cities-Looking Beyond Hospitals and Medical Schools for Neurotherapy Part 1: When TBI patients report feeling 'awful' and 'terrible', an attending physician too often relies on the most extreme measures of pharmaceutical medications first before exploring root causes. Connecting patients to the right medical and therapy professionals can be blinkered and random, or it might not happen at all. Seen as a whole person, a TBI patient's condition and course of treatment must account for the interdisciplinary nature of a brain injury. Therapeutic interventions have as much to do with recovery as medical ones. The Brain Injury Recovery Team Model provides a roadmap for recovery, systematizing options that attending physicians often leave unexplored. The model ensures efficiency and efficacy in building a recovery team specific to the patient. Attending physicians can use the model to make key referral decisions deliberately. Medical and therapy professionals can use this model to work with patients and their caregivers to prevent undiagnosed and misdiagnosed brain injuries, particularly mild TBIs when the patient might 'look great!' The Model comprises specific medical and therapy specialists. Participants will be able to describe the role of these medical specialists: Endocrinologist, Neuropsychiatrist, Neuropsychologist, Neuro-optometrist, Psychopharmacologist, and Vestibular and Sleep Study Specialists. They will also learn the role of these therapy specialists: Occupational and Physical Therapist, Social Worker, Speech-Language Pathologist and Vocational Rehabilitation Counselors. Survivors can and should look to these specialists for: Emotional Support, Informed Guidance and Tactical Support. Part 2: After 2 1/2 or 3 years, rehabilitation hospitals often begin denying survivors access to their recovery team, leaving them on their own to figure out how to live the rest of their lives overcoming their cognitive deficiencies. There is a reason why we are losing 22 veterans a day to suicide: They might 'look great' but they have no strategies for living inside their brain injuries. The key point to this part of the presentation-Neuro Plastic Cities-is that just as a brain injury is as specific as a fingerprint, so should the course of treatments be. Survivors of brain injury owe it to themselves to try as many therapies and treatments as they can afford, and arrive at an intricate combination that works best for them. Therapies that work for some survivors are less effective for others, hence the need for guided experimentation. In addition to fundamental brain-healthy nutrition and exercise, I overview such treatments as Hyperbaric Oxygen Chambers, Cranial Sacral, Reiki, Acupuncture, Music, Medical Marijuana, Tai Chi, Qi Gong, Reflexology, Yoga, Faith Healing and Cognitive Behavioural Therapy. AD - J. Byler, Operational and Neurological, Hesston, KS, United States AU - Byler, J. DB - Embase DO - 10.1080/02699052.2017.1312145 KW - medical cannabis acupuncture animal model brain injury caregiver city clinical study cognitive behavioral therapy counselor diagnostic error disease model endocrinologist exercise female hospital human hyperbaric oxygen therapy male medical school medical specialist mental deficiency music nutrition optometrist patient referral physiotherapist qigong reflexology rehabilitation Reiki remission rest sacral spinal cord sleep social worker speech language pathologist spiritual healing suicide survivor Tai Chi vestibule veteran vocational rehabilitation LA - English M1 - 6-7 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 1362-301X SP - 827-828 ST - Neuroplastic cities: Looking beyond hospitals and medical schools for neurotherapy T2 - Brain Injury TI - Neuroplastic cities: Looking beyond hospitals and medical schools for neurotherapy UR - https://www.embase.com/search/results?subaction=viewrecord&id=L617352863&from=export http://dx.doi.org/10.1080/02699052.2017.1312145 VL - 31 ID - 931918 ER - TY - JOUR AB - INTRODUCTION: We evaluated magnetic resonance spectroscopy (MRS) in United States military personnel with persistent symptoms after mild traumatic brain injury (mTBI), comparing over time two groups randomized to receive hyperbaric oxygen or sham chamber sessions and a third group of normative controls. METHODS: Active-duty or veteran military personnel and normative controls underwent MRS outcome measures at baseline, 13 weeks (mTBI group only), and six months. Participants received 3.0 Tesla brain MRS for analysis of water-suppressed two-dimensional (2D) multivoxel 1H-MRS of the brain using point resolved spectroscopy (PRESS) with volume selection localized above the lateral ventricles and within the brain parenchyma, of which one voxel was chosen in each hemisphere without artifact. Script-based automatic data processing was used to assess N-acetylaspartate (NAA), creatine (Cr), and choline (Cho). Metabolite ratios for white matter were then calculated for NAA/Cr (Area), Cho/Cr (Area), and Cho/NAA (Area). These ratios were compared using standard analysis methodology. RESULTS: There were no observable differences between participants with mTBI and normative controls nor any observable changes over time in the NAA/Cr (area), Cho/Cr (area), and Cho/NAA (area) ratios. Similarly, the control and injured participants were indistinguishable. DISCUSSION: While participants with mild TBI showed no difference in MRS compared to normative controls, our results are limited by the few voxels chosen and potentially by less sensitive MRS markers. AD - Imgen LLC, Las Vegas, Nevada U.S. Philips Healthcare, Cleveland, Ohio U.S. Perkins Consultative Resources LLC, Fort Collins, Colorado U.S. Emmes, Rockville, Maryland U.S. Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain LDS Hospital, Salt Lake City, Utah U.S. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah U.S. Nevada Imaging Centers, Las Vegas, Nevada U.S. University of Nevada Las Vegas, Department of Health Physics, Las Vegas, Nevada U.S. Touro University Nevada, College of Osteopathic Medicine, Las Vegas, Nevada U.S. AN - 31394599 AU - Cartwright, P. E. AU - Perkins, T. G. AU - Wilson, S. H. AU - Weaver, L. K. AU - Orrison, W. W. DA - BIMA Special Edition No. Feb DP - NLM ET - 2019/08/09 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Aspartic Acid/*analogs & derivatives/analysis *Brain Chemistry Brain Concussion/*metabolism/therapy Case-Control Studies Choline/*analysis Creatine/*analysis Female Humans Hyperbaric Oxygenation Lateral Ventricles/chemistry Magnetic Resonance Spectroscopy/*methods Male Military Personnel Post-Concussion Syndrome/metabolism Time Factors Veterans concussion mild traumatic brain injury randomized trial spectroscopy submission. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 1066-2936 (Print) 1066-2936 SP - 291-297 ST - Analysis of magnetic resonance spectroscopy relative metabolite ratios in mild traumatic brain injury and normative controls T2 - Undersea Hyperb Med TI - Analysis of magnetic resonance spectroscopy relative metabolite ratios in mild traumatic brain injury and normative controls VL - 46 ID - 931849 ER - TY - GEN AN - NCT00715052 AU - Center, Assaf-Harofeh Medical DA - August KW - Neurologic Deficiency|Traumatic Brain Injury N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT00715052 PY - 2008 ST - The Effect of Hyperbaric Oxygen Therapy on Patients Suffering From Neurologic Deficiency Due Traumatic Brain Injury TI - The Effect of Hyperbaric Oxygen Therapy on Patients Suffering From Neurologic Deficiency Due Traumatic Brain Injury ID - 932047 ER - TY - GEN AN - NCT03376269 AU - Center, Assaf-Harofeh Medical DA - December KW - Fibromyalgia|Chronic Pain Syndrome N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT03376269 PY - 2014 ST - hbotcsa TI - HBOT Effect on Chronic Pain Syndrome With a History of Psychological Trauma ID - 932051 ER - TY - GEN AN - NCT03466554 AU - Center, Assaf-Harofeh Medical DA - March 4 KW - Ptsd N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT03466554 PY - 2018 ST - Hyperbaric Oxygen Therapy for Adult Onset Post Traumatic Stress Disorder TI - Hyperbaric Oxygen Therapy for Adult Onset Post Traumatic Stress Disorder ID - 932048 ER - TY - GEN AN - NCT00810615 AU - Center, San Antonio Military Medical DA - February KW - Brain Injury, Chronic N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT00810615 PY - 2009 ST - Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy TI - Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy ID - 932045 ER - TY - JOUR AB - Safety monitoring and successful blinding are important features of randomized, blinded clinical trials. We report chamber- and protocol-related adverse events (AEs) for participants enrolled in two randomized, double-blind clinical trials of hyperbaric oxygen (HBO2) for persistent post-concussive symptoms clinicaltrials.gov identifiers NCT01306968, HOPPS, and NCT01611194, BIMA), as well as the success of maintaining the blind with a low-pressure sham control arm. In both studies, participants were randomized to receive HBO2 (1.5 atmospheres absolute, >99% oxygen) or sham chamber sessions (1.2 atmospheres absolute, room air). In 143 participants undergoing 4,245 chamber sessions, chamber-related adverse events were rare (1.1% in the HOPPS study, 2.2% in the BIMA study). Minor, non-limiting barotrauma was the most frequently reported. Rarely, some participants experienced headache with chamber sessions. No serious adverse events were associated with chamber sessions. An allocation questionnaire completed after intervention revealed that the sham control arm adequately protected the blind in both trials. Participants based allocation assumptions on symptom improvement or lack of symptom improvement and could not discern intervention arm by pressure, smell, taste, or gas flow. AD - Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain LDS Hospital, Salt Lake City, Utah U.S. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah U.S. Emmes, Rockville, Maryland U.S. The Gates Foundation, Seattle, Washington U.S. AN - 31394602 AU - Churchill, S. AU - Deru, K. AU - Weaver, L. K. AU - Wilson, S. H. AU - Hebert, D. AU - Miller, R. S. AU - Lindblad, A. S. DA - BIMA Special Edition No. Feb DP - NLM ET - 2019/08/09 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Barotrauma/etiology Brain Concussion/complications Double-Blind Method Earache/etiology Female Headache/etiology Humans Hyperbaric Oxygenation/*adverse effects/methods Male Military Personnel Pilot Projects Post-Concussion Syndrome/*therapy Random Allocation Safety adverse events hyperbaric oxygenation mild traumatic brain injury post-concussive syndrome safety submission. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 1066-2936 (Print) 1066-2936 SP - 331-340 ST - Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms T2 - Undersea Hyperb Med TI - Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms VL - 46 ID - 931841 ER - TY - JOUR AB - Simple reaction time (SRT) and procedural reaction time (PRT) are speed-of-processing tasks in the Automated Neuropsychological Assessment Metrics (ANAM) that may be sensitive to mild traumatic brain injury (mTBI). The investigators measured SRT and PRT throughput (correct responses per minute) at baseline, 6 weeks, and 13 weeks in military personnel with mTBI randomized to local care or 40 chamber sessions (sham-1.2 atmospheres absolute [ATA] air, hyperbaric oxygen-1.5 ATA O2). Scores were assessed at baseline using univariate analysis of variance and across time with repeated measures methods. Data reported as throughput standard scores (mean = 100, SD = 15). Seventy-two participants with ongoing symptoms after mTBI enrolled in the study (three female, median age 31 years, mean three lifetime concussion events, most recent mTBI 23 months prior). Sixty-four had Automated Neuropsychological Assessment Metrics data at 13 weeks. SRT and PRT throughput standard scores were comparable across groups at baseline. Over time, SRT scores did not change in the hyperbaric oxygen or sham groups and decreased in the local care group. PRT throughput standard scores increased from baseline to mid-intervention and decreased from mid-intervention to postintervention in all groups. Repeated measures change over time in SRT (p = 0.23), and PRT (p = 0.17) scores were not different among groups. This study may be underpowered to detect statistically significant change. AD - Division of Hyperbaric Medicine, LDS Hospital, 8th Avenue & C Street, Salt Lake City, UT 84143. Uniformed Services University of Health Sciences, 11803 Prestwick Road, Potomac, MD 20854. The Emmes Corporation, 401 North Washington Street, Suite 700, Rockville, MD 20850. AN - 27168551 AU - Churchill, S. AU - Miller, R. S. AU - Deru, K. AU - Wilson, S. H. AU - Weaver, L. K. DA - May DO - 10.7205/milmed-d-15-00148 DP - NLM ET - 2016/05/12 J2 - Military medicine KW - Adult Brain Concussion/classification/complications/*therapy Brain Injuries/psychology/therapy Cognitive Dysfunction Female Humans Hyperbaric Oxygenation/*methods Male Middle Aged Military Personnel/*psychology Neuropsychological Tests Oxygen/therapeutic use *Reaction Time LA - eng M1 - 5 Suppl N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 0026-4075 SP - 40-4 ST - Simple and Procedural Reaction Time for Mild Traumatic Brain Injury in a Hyperbaric Oxygen Clinical Trial T2 - Mil Med TI - Simple and Procedural Reaction Time for Mild Traumatic Brain Injury in a Hyperbaric Oxygen Clinical Trial VL - 181 ID - 931866 ER - TY - JOUR AD - University of North Carolina at Chapel Hill, Chapel Hill, NC. University of Georgia, Athens, GA. Duke University, Durham, NC. Carolina Family Practice & Sports Medicine, Raleigh, NC. AN - 133524251. Language: English. Entry Date: 20181231. Revision Date: 20190603. Publication Type: Abstract AU - Combs, Patricia R. AU - Lynall, Robert C. AU - Marshall, Stephen W. AU - Fonseca, Janna C. AU - Stevens, James R. AU - Mihalik, Jason P. DB - CINAHL DO - 10.1249/01.mss.0000535844.58533.93 DP - EBSCOhost KW - American College of Sports Medicine Athletic Injuries Brain Injuries -- Therapy Hyperbaric Oxygenation Congresses and Conferences -- Minnesota Minnesota N1 - CINAHL (EbscoHost) Literature search date last searched June 18, 2021 PY - 2018 SN - 0195-9131 SP - 230-230 ST - Treating Pediatric Acute Sport-Related Traumatic Brain Injuries with Hyperbaric Oxygen Therapy: A Case Series: 980 Board #241 May 30 3:30 PM - 5:00 PM...American College of Sports Medicine Annual Meeting, May 29-June 2, 2018, Minneapolis, Minnesota T2 - Medicine & Science in Sports & Exercise TI - Treating Pediatric Acute Sport-Related Traumatic Brain Injuries with Hyperbaric Oxygen Therapy: A Case Series: 980 Board #241 May 30 3:30 PM - 5:00 PM...American College of Sports Medicine Annual Meeting, May 29-June 2, 2018, Minneapolis, Minnesota UR - http://libproxy.temple.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=133524251&site=ehost-live&scope=site VL - 50 ID - 932033 ER - TY - JOUR AB - Traumatic brain injury (TBI) has a high incidence worldwide and is associated with significant morbidity and mortality. TBI has enduring implications in several domains and limits overall quality of life even in the survivors. Assessment of failures of different strategies attempted at improving outcomes in traumatic brain injury is required. Several neuroprotective strategies have been studied to limit the morbidity and mortality associated with TBI. Various approaches, both pharmacologic and surgical, have been tried. In this article, we will review the epidemiology of TBI, the impact of secondary brain injury on outcomes and different strategies in traumatic brain injury. Furthermore, discussion into failure of different strategies and necessary future approach will be discussed. TBI remains a challenging condition to intervene on due to its heterogeneity. Future work should incorporate a multi-disciplinary as well as multi-center approach to target specific subset of patient population. AD - M. Desai, Department of Neurology, University of Maryland Medical Center, 22 S Greene St, Baltimore, MD, United States AU - Desai, M. AU - Jain, A. DB - Embase Medline DO - 10.23736/S0390-5616.18.04476-4 KW - acetylcysteine beta adrenergic receptor blocking agent cyclosporine erythropoietin glibenclamide interleukin 10 interleukin 1beta interleukin 6 levetiracetam phenytoin progesterone rosuvastatin steroid tumor necrosis factor blood brain barrier brain damage brain vasospasm clinical outcome cognition computer assisted tomography decompressive craniectomy depolarization electroencephalography monitoring epidural hematoma Glasgow outcome scale human hyperbaric oxygen therapy hyperoxia hypothermia intracranial hypertension intracranial pressure mortality nerve cell membrane potential nervous system inflammation neuroprotection perfusion pressure quality of life resuscitation review seizure subarachnoid hemorrhage subdural hematoma traumatic brain injury LA - English M1 - 5 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2018 SN - 1827-1855 0390-5616 SP - 563-573 ST - Neuroprotection in traumatic brain injury T2 - Journal of Neurosurgical Sciences TI - Neuroprotection in traumatic brain injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L623910936&from=export http://dx.doi.org/10.23736/S0390-5616.18.04476-4 VL - 62 ID - 931903 ER - TY - JOUR AB - Despite the large number of promising neuroprotective agents identified in experimental traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long-term outcome in clinical trials. To develop recommendations and guidelines for pre-clinical testing of pharmacological or biological therapies for TBI, the Moody Project for Translational Traumatic Brain Injury Research hosted a symposium attended by investigators with extensive experience in pre-clinical TBI testing. The symposium participants discussed issues related to pre-clinical TBI testing including experimental models, therapy and outcome selection, study design, data analysis, and dissemination. Consensus recommendations included the creation of a manual of standard operating procedures with sufficiently detailed descriptions of modeling and outcome measurement procedures to permit replication. The importance of the selection of clinically relevant outcome variables, especially related to behavior testing, was noted. Considering the heterogeneous nature of human TBI, evidence of therapeutic efficacy in multiple, diverse (e.g., diffuse vs. focused) rodent models and a species with a gyrencephalic brain prior to clinical testing was encouraged. Basing drug doses, times, and routes of administration on pharmacokinetic and pharmacodynamic data in the test species was recommended. Symposium participants agreed that the publication of negative results would reduce costly and unnecessary duplication of unsuccessful experiments. Although some of the recommendations are more relevant to multi-center, multi-investigator collaborations, most are applicable to pre-clinical therapy testing in general. The goal of these consensus guidelines is to increase the likelihood that therapies that improve outcomes in pre-clinical studies will also improve outcomes in TBI patients. AD - D.S. DeWitt, Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, United States AU - DeWitt, D. S. AU - Hawkins, B. E. AU - Dixon, C. E. AU - Kochanek, P. M. AU - Armstead, W. AU - Bass, C. R. AU - Bramlett, H. M. AU - Buki, A. AU - Dietrich, W. D. AU - Ferguson, A. R. AU - Hall, E. D. AU - Hayes, R. L. AU - Hinds, S. R. AU - Laplaca, M. C. AU - Long, J. B. AU - Meaney, D. F. AU - Mondello, S. AU - Noble-Haeusslein, L. J. AU - Poloyac, S. M. AU - Prough, D. S. AU - Robertson, C. S. AU - Saatman, K. E. AU - Shultz, S. R. AU - Shear, D. A. AU - Smith, D. H. AU - Valadka, A. B. AU - Vandevord, P. AU - Zhang, L. DB - Embase Medline DO - 10.1089/neu.2018.5778 KW - amantadine glibenclamide levetiracetam minocycline neuroprotective agent nimodipine phenytoin placebo poloxamer progesterone article brain blood flow chronic traumatic encephalopathy clinical outcome consensus craniectomy data analysis decision making disease model drug administration route drug dose experimental traumatic brain injury human hyperbaric oxygen therapy induced hypothermia medical research neuroprotection nonhuman outcome assessment practice guideline preclinical study randomized controlled trial (topic) study design symposium time to treatment traumatic brain injury treatment duration LA - English M1 - 23 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2018 SN - 1557-9042 0897-7151 SP - 2737-2754 ST - Pre-clinical testing of therapies for traumatic brain injury T2 - Journal of Neurotrauma TI - Pre-clinical testing of therapies for traumatic brain injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L625124569&from=export http://dx.doi.org/10.1089/neu.2018.5778 VL - 35 ID - 931901 ER - TY - JOUR AB - Fibromyalgia Syndrome (FMS) is a condition considered to represent a prototype of central sensitization syndrome, characterized by chronic widespread pain and along with symptoms of fatigue, non-restorative sleep and cognitive difficulties. FMS can be induced by trauma, infection or emotional stress with cumulative evidence that dissociation is relatively frequent in FMS patients. Two randomized controlled trials have shown that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity and be effective in patients suffering from FMS. In this paper we present, for the first time, case series of female fibromyalgia patients who, in the course of HBOT, suddenly recalled repressed traumatic memories of childhood sexual abuse (CSA). The surfacing of the repressed (dissociative) memories decades after the sexual abuse events was sudden and utterly surprising. No psychological intervention was involved. As the memories surfaced, the physical pain related to FMS subsided. In one patient who had brain single photon emission CT (SPECT) before and after HBOT, the prefrontal cortex appeared suppressed before and reactivated after. The 3 cases reported in this article are representative of a total of nine fibromyalgia patients who experienced a retrieval of repressed memory during HBOT. These cases provide insights on dissociative amnesia and suggested mechanism hypothesis that is further discussed in the article. Obviously, prospective studies cannot be planned since patients are not aware of their repressed memories. However, it is very important to keep in mind the possibility of surfacing memories when treating fibromyalgia patients with HBOT or other interventions capable of awakening dormant brain regions. AD - [Efrati, Shai; Hadanny, Amir; Bechor, Yair; Suzin, Gil] Assaf Harofeh Med Ctr, Sagol Ctr Hyperbar Med & Res, Zerifin, Israel. [Efrati, Shai; Hadanny, Amir] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel. [Efrati, Shai] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel. [Daphna-Tekoah, Shir] Ashkelon Acad Coll, Ashqelon, Israel. [Daphna-Tekoah, Shir] Social Work Dept, Kaplan Med Ctr, Rehovot, Israel. [Tiberg, Kobi] Loewenstein Hosp Rehabil Ctr, Dept Psychol, Raanana, Israel. [Pik, Nimrod] Assaf Harofeh Med Ctr, Psychiat Serv, Zerifin, Israel. [Lev-Wiesel, Rachel] Univ Haifa, Grad Sch Creat Arts Therapies, Emili Sagol CAT Res Ctr, Haifa, Israel. Efrati, S (corresponding author), Assaf Harofeh Med Ctr, Sagol Ctr Hyperbar Med & Res, Zerifin, Israel.; Efrati, S (corresponding author), Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.; Efrati, S (corresponding author), Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel. efratishai@013.net AN - WOS:000433395000001 AU - Efrati, S. AU - Hadanny, A. AU - Daphna-Tekoah, S. AU - Bechor, Y. AU - Tiberg, K. AU - Pik, N. AU - Suzin, G. AU - Lev-Wiesel, R. C7 - 848 DA - May DO - 10.3389/fpsyg.2018.00848 J2 - Front. Psychol. KW - hyperbaric oxygen repressed memories fibromyalgia biopsychophysical mechanism childhood sexual abuse POST-CONCUSSION SYNDROME TRAUMATIC BRAIN-INJURY MAMMALIAN HIBERNATION RHEUMATOID-ARTHRITIS NERVE REGENERATION ISCHEMIC PENUMBRA PROTEIN-SYNTHESIS CHILDHOOD ABUSE THERAPY DAMAGE Psychology, Multidisciplinary LA - English M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2018 SN - 1664-1078 SP - 8 ST - Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen - Case Series Presentation and Suggested Bio-Psycho-Social Mechanism T2 - Frontiers in Psychology TI - Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen - Case Series Presentation and Suggested Bio-Psycho-Social Mechanism UR - ://WOS:000433395000001 VL - 9 ID - 932002 ER - TY - JOUR AB - Traumatic brain injury (TBI) describes the presence of physical damage to the brain as a consequence of an insult and frequently possesses psychological and neurological symptoms depending on the severity of the injury. The recent increased military presence of US troops in Iraq and Afghanistan has coincided with greater use of improvised exploding devices, resulting in many returning soldiers suffering from some degree of TBI. A biphasic response is observed which is first directly injury-related, and second due to hypoxia, increased oxidative stress, and inflammation. A proportion of the returning soldiers also suffer from post-traumatic stress disorder (PTSD), and in some cases, this may be a consequence of TBI. Effective treatments are still being identified, and a possible therapeutic candidate is hyperbaric oxygen therapy (HBOT). Some clinical trials have been performed which suggest benefits with regard to survival and disease severity of TBI and/or PTSD, while several other studies do not see any improvement compared to a possibly poorly controlled sham. HBOT has been shown to reduce apoptosis, upregulate growth factors, promote antioxidant levels, and inhibit inflammatory cytokines in animal models, and hence, it is likely that HBOT could be advantageous in treating at least the secondary phase of TBI and PTSD. There is some evidence of a putative prophylactic or preconditioning benefit of HBOT exposure in animal models of brain injury, and the optimal time frame for treatment is yet to be determined. HBOT has potential side effects such as acute cerebral toxicity and more reactive oxygen species with long-term use, and therefore, optimizing exposure duration to maximize the reward and decrease the detrimental effects of HBOT is necessary. This review provides a summary of the current understanding of HBOT as well as suggests future directions including prophylactic use and chronic treatment. AD - C.V. Borlongan, Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC-78, Tampa, FL, United States AU - Eve, D. J. AU - Steele, M. R. AU - Sanberg, P. R. AU - Borlongan, C. V. DB - Embase DO - 10.2147/NDT.S110126 KW - NCT00170352 NCT00263367 NCT00290186 NCT00324909 NCT00335790 NCT00406159 NCT00584480 NCT00592891 NCT00594503 NCT00596180 NCT00670891 NCT00715052 NCT00760734 NCT00810615 NCT00830453 NCT01105962 NCT01126515 NCT01220713 NCT01306968 NCT01611194 NCT01847755 NCT01925963 NCT01986205 NCT02085330 NCT02089594 NCT02407028 NCT02452619 serotonin uptake inhibitor autism barotrauma blood brain barrier brain damage brain hypoxia carbon monoxide intoxication cerebral palsy claustrophobia convulsion dyspnea eardrum perforation Glasgow coma scale headache human hyperbaric oxygen therapy injury severity mild cognitive impairment myopia nausea nervous system inflammation nonhuman paresthesia postconcussion syndrome posttraumatic stress disorder review military personnel traumatic brain injury LA - English M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1178-2021 1176-6328 SP - 2689-2705 ST - Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury T2 - Neuropsychiatric Disease and Treatment TI - Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L612916004&from=export http://dx.doi.org/10.2147/NDT.S110126 VL - 12 ID - 931924 ER - TY - JOUR AB - Traumatic brain injury (TBI) arises from physical damage to the brain as the consequence of an insult and is reflected by psychological and neurological symptoms depending on the severity of the injury. The increase in the use of improvised exploding devices (IEDs) during the recent excursions in Iraq and Afghanistan mean that the US's returning soldiers frequently suffer from some degree of TBI. The primary phase is directly injury related, while a secondary phase arises due to hypoxia, increased oxidative stress, and inflammation. In addition, exposure to the consequences of this warfare mean that a proportion of the returning soldiers are also suffering from posttraumatic stress disorder (PTSD). There is some evidence that PTSD may be a consequence of TBI in some instances. The search for an effective treatment is ongoing and one possible therapeutic candidate is hyperbaric oxygen therapy (HBOT). Some clinical trials suggest benefit with regards to survival and disease severity, while others do not see any improvement compared to a sham, though several of these studies are poorly controlled. Since HBOT has been shown to reduce apoptosis, upregulate growth factors, promote antioxidant levels, and inhibit inflammatory cytokines, there is likely to be an advantageous effect of HBOT in treating at least the secondary phase of TBI and PTSD. The precise timing(s) of HBOT exposure still need to be determined along with the consideration of a putative role of prophylactic (or preconditioning) exposure. One caveat is that acute cerebral toxicity and other deleterious effects, partly due to the increased oxygen levels generating more reactive oxygen species, can occur following exposure to HBOT and so optimizing exposure duration to maximize the reward and decrease the detrimental effects of HBOT will be necessary. In this presentation, we will be providing an overview of our current knowledge and recommendations for future directions including prophylactic use and chronic treatment. AD - D.J. Eve, Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, United States AU - Eve, D. J. AU - Steele, M. R. AU - Sanberg, P. R. AU - Borlongan, C. V. DB - Embase DO - 10.3727/096368916X691169 KW - antioxidant cytokine endogenous compound growth factor oxygen reactive oxygen metabolite Afghanistan apoptosis clinical trial controlled study exposure gene inactivation human hyperbaric oxygen therapy hypoxia inflammation Iraq long term care neurologic disease oxidative stress posttraumatic stress disorder reward tissue oxygenation toxicity traumatic brain injury warfare LA - English M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 0963-6897 SP - 756 ST - Hyperbaric oxygen therapy as a potential treatment for traumatic brain injury and associated posttraumatic stress disorder T2 - Cell Transplantation TI - Hyperbaric oxygen therapy as a potential treatment for traumatic brain injury and associated posttraumatic stress disorder UR - https://www.embase.com/search/results?subaction=viewrecord&id=L612003621&from=export http://dx.doi.org/10.3727/096368916X691169 VL - 25 ID - 931947 ER - TY - JOUR AB - Objective: First, to demonstrate that B-level evidence exists for the use of hyperbaric oxygen therapy (HBOT) as an effective treatment in mild to moderate traumatic brain injury/persistent postconcussion syndrome (mTBI/PPCS). Second, to alert readers and researchers that currently used pressurized air controls (≥21% O 2, >1.0 ATA) are therapeutically active and cannot be utilized as sham controls without further validation. Method: Review of published, peer-reviewed articles of HBOT prospective and controlled clinical trials of mTBI/PPCS symptoms. Results: Published results demonstrate that HBOT is effective in the treatment of mTBI/PPCS symptoms. Doses of oxygen that are applied at ≥21% O 2 and at pressures of >1.0 ATA produce improvements from baseline measures. Some of the recently published clinical trials are mischaracterized as sham-controlled clinical trials (i.e., sham 21% O 2 /1.2-1.3 ATA), but are best characterized as dose-varying (variation in oxygen concentration, pressure applied, or both) clinical trials. Conclusions: Hyperbaric oxygen and hyperbaric air have demonstrated therapeutic effects on mTBI/PPCS symptoms and can alleviate posttraumatic stress disorder symptoms secondary to a brain injury in 5 out of 5 peer-reviewed clinical trials. The current use of pressurized air (1.2-1.3 ATA) as a placebo or sham in clinical trials biases the results due to biological activity that favors healing. AD - X.A. Figueroa, Brain Health and Healing Foundation, Seattle, WA, United States AU - Figueroa, X. A. AU - Wright, J. K. DB - Embase Medline DO - 10.1212/WNL.0000000000003146 KW - dissolved oxygen oxygen prescription drug clinical trial (topic) human hydrostatic pressure hyperbaric oxygen therapy hyperbarism oxygen concentration postconcussion syndrome priority journal review therapy effect traumatic brain injury LA - English M1 - 13 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1526-632X 0028-3878 SP - 1400-1406 ST - Hyperbaric oxygen T2 - Neurology TI - Hyperbaric oxygen UR - https://www.embase.com/search/results?subaction=viewrecord&id=L612435163&from=export http://dx.doi.org/10.1212/WNL.0000000000003146 VL - 87 ID - 931926 ER - TY - JOUR AD - Seattle. Port Townsend, WA. AN - 28808167 AU - Figueroa, X. A. AU - Wright, J. K. DA - Aug 15 DO - 10.1212/wnl.0000000000004252 DP - NLM ET - 2017/08/16 J2 - Neurology KW - *Brain Concussion *Brain Injuries *Brain Injuries, Traumatic Humans *Hyperbaric Oxygenation Oxygen LA - eng M1 - 7 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2017 SN - 0028-3878 SP - 750-751 ST - Author response: Hyperbaric oxygen: B-Level evidence in mild traumatic brain injury clinical trials T2 - Neurology TI - Author response: Hyperbaric oxygen: B-Level evidence in mild traumatic brain injury clinical trials VL - 89 ID - 931872 ER - TY - JOUR AB - Reply by the current author to the comments made by Neil B. Hampson & James Holm (see record [rid]2017-35398-020[/rid]) on the original article (see record [rid]2016-46767-018[/rid]). It is true that PaO2 was not measured in the published studies and assumptions were made regarding normal metabolism and pulmonary function of the study participants. This was a valid assumption, as all participants were cleared to be placed inside a pressure vessel and not excluded due to pulmonary or metabolic dysfunctions. (PsycINFO Database Record (c) 2017 APA, all rights reserved) AN - 2017-35398-021 AU - Figueroa, Xavier A. AU - Wright, James K. DB - APA PsycInfo DO - 10.1212/WNL.0000000000004252 DP - EBSCOhost KW - traumatic brain injury treatment placebo Brain Concussion Medical Treatment (General) M1 - 7 N1 - PsycInfo (EbscoHost) Literature search June 18, 2021 PY - 2017 SN - 0028-3878 1526-632X SP - 750-751 ST - 'Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials': Author's response T2 - Neurology TI - 'Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials': Author's response UR - http://libproxy.temple.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2017-35398-021&site=ehost-live&scope=site VL - 89 ID - 932036 ER - TY - JOUR AB - The goals of phase II clinical trials are to gain important information about the performance of novel treatments and decide whether to conduct a larger phase III trial. This can be complicated in cases when the phase II trial objective is to identify a novel treatment having several factors. Such multifactor treatment scenarios can be explored using fixed sample size trials. However, the alternative design could be response adaptive randomization with interim analyses and additionally, longitudinal modeling whereby more data could be used in the estimation process. This combined approach allows a quicker and more responsive adaptation to early estimates of later endpoints. Such alternative clinical trial designs are potentially more powerful, faster, and smaller than fixed randomized designs. Such designs are particularly challenging, however, because phase II trials tend to be smaller than subsequent confirmatory phase III trials. The phase II trial may need to explore a large number of treatment variations to ensure that the efficacy of optimal clinical conditions is not overlooked. Adaptive trial designs need to be carefully evaluated to understand how they will perform and to take full advantage of their potential benefits. This manuscript discusses a Bayesian response adaptive randomization design with a longitudinal model that uses a multifactor approach for predicting phase III study success via the phase II data. The approach is based on an actual clinical trial design for the hyperbaric oxygen brain injury treatment trial. Specific details of the thought process and the models informing the trial design are provided. Copyright © 2016 John Wiley & Sons, Ltd. AD - B.J. Gajewski, Department of Biostatistics, University of Kansas Medical Center, Mail Stop 1026, 3901 Rainbow Blvd., Kansas City, KS, United States AU - Gajewski, B. J. AU - Berry, S. M. AU - Barsan, W. G. AU - Silbergleit, R. AU - Meurer, W. J. AU - Martin, R. AU - Rockswold, G. L. DB - Embase Medline DO - 10.1002/pst.1755 KW - article Bayes theorem clinical article controlled study human hyperbaric oxygen therapy longitudinal modeling longitudinal study phase 2 clinical trial phase 3 clinical trial response adaptive randomization sample size statistical model traumatic brain injury treatment response LA - English M1 - 5 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1539-1612 1539-1604 SP - 396-404 ST - Hyperbaric oxygen brain injury treatment (HOBIT) trial: a multifactor design with response adaptive randomization and longitudinal modeling T2 - Pharmaceutical Statistics TI - Hyperbaric oxygen brain injury treatment (HOBIT) trial: a multifactor design with response adaptive randomization and longitudinal modeling UR - https://www.embase.com/search/results?subaction=viewrecord&id=L612231577&from=export http://dx.doi.org/10.1002/pst.1755 VL - 15 ID - 931927 ER - TY - JOUR AB - A primary goal of a phase II dose-ranging trial is to identify a correct dose before moving forward to a phase III confirmatory trial. A correct dose is one that is actually better than control. A popular model in phase II is an independent model that puts no structure on the dose-response relationship. Unfortunately, the independent model does not efficiently use information from related doses. One very successful alternate model improves power using a pre-specified dose-response structure. Past research indicates that EMAX models are broadly successful and therefore attractive for designing dose-response trials. However, there may be instances of slight risk of nonmonotone trends that need to be addressed when planning a clinical trial design. We propose to add hierarchical parameters to the EMAX model. The added layer allows information about the treatment effect in one dose to be "borrowed" when estimating the treatment effect in another dose. This is referred to as the hierarchical EMAX model. Our paper compares three different models (independent, EMAX, and hierarchical EMAX) and two different design strategies. The first design considered is Bayesian with a fixed trial design, and it has a fixed schedule for randomization. The second design is Bayesian but adaptive, and it uses response adaptive randomization. In this article, a randomized trial of patients with severe traumatic brain injury is provided as a motivating example. AD - Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, Kansas. Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina. Berry Consultants, LLC, Austin, Texas. Hennepin County Medical Center, Minneapolis, Minnesota. Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan. AN - 31070807 AU - Gajewski, B. J. AU - Meinzer, C. AU - Berry, S. M. AU - Rockswold, G. L. AU - Barsan, W. G. AU - Korley, F. K. AU - Martin, R. H. C2 - Pmc6606375 C6 - Nihms1018561 DA - Jul 30 DO - 10.1002/sim.8167 DP - NLM ET - 2019/05/10 J2 - Statistics in medicine KW - Bayes Theorem *Clinical Trials, Phase II as Topic *Dose-Response Relationship, Drug Humans *Hyperbaric Oxygenation *Models, Statistical Multicenter Studies as Topic Prospective Studies *Randomized Controlled Trials as Topic *Research Design *Emax *dosing design, Bayesian models *hierarchical models *logistic LA - eng M1 - 17 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 0277-6715 (Print) 0277-6715 SP - 3123-3138 ST - Bayesian hierarchical EMAX model for dose-response in early phase efficacy clinical trials T2 - Stat Med TI - Bayesian hierarchical EMAX model for dose-response in early phase efficacy clinical trials VL - 38 ID - 931854 ER - TY - JOUR AB - OBJECTIVE: Neuroinflammation plays an important role in secondary tissue damage after traumatic brain injury (TBI). Recently, the inflammasome-mediated inflammatory pathway has been observed in the inflammatory response of TBI. In this study, we investigated the influence of hyperbaric oxygen therapy (HBOT) on inflammasome activation after TBI. METHODS: The experimental mice were randomly divided into 4 groups as follows: sham-operated normobaric air (21% O2 at one absolute atmosphere), HBOT only, TBI + normobaric air and TBI + HBOT. Following the evaluation of motor deficits and brain edema, the expression of inflammasome components and effectors was measured by qRT-PCR and Western blotting. Moreover, alterations in IL-1β, IL-18 and high-mobility group box 1 (HMGB1) were calculated by enzyme-linked immunosorbent assay at each time point after injury. RESULTS: HBOT improved motor score and reduced brain edema. Furthermore, it suppressed protein expression of inflammasome components and reduced the levels of IL-1β and IL-18, accompanied by the reduction of HMGB1 in brain tissues and serum. CONCLUSION: These results suggest that HBOT may alleviate the inflammatory response after TBI by inhibiting the activation of inflammasome signaling. AD - Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, PR China. AN - 27216735 AU - Geng, F. AU - Ma, Y. AU - Xing, T. AU - Zhuang, X. AU - Zhu, J. AU - Yao, L. DO - 10.1159/000445689 DP - NLM ET - 2016/05/25 J2 - Neuroimmunomodulation KW - Animals Brain Injuries, Traumatic/*metabolism/*therapy Hyperbaric Oxygenation/*methods/trends Inflammasomes/*physiology Male Mice Mice, Inbred C57BL Motor Activity/physiology Random Allocation Signal Transduction/*physiology Treatment Outcome LA - eng M1 - 2 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1021-7401 SP - 122-9 ST - Effects of Hyperbaric Oxygen Therapy on Inflammasome Signaling after Traumatic Brain Injury T2 - Neuroimmunomodulation TI - Effects of Hyperbaric Oxygen Therapy on Inflammasome Signaling after Traumatic Brain Injury VL - 23 ID - 931856 ER - TY - JOUR AB - Objective: Neuroinflammation plays an important role in secondary tissue damage after traumatic brain injury (TBI). Recently, the inflammasome-mediated inflammatory pathway has been observed in the inflammatory response of TBI. In this study, we investigated the influence of hyperbaric oxygen therapy (HBOT) on inflammasome activation after TBI. Methods: The experimental mice were randomly divided into 4 groups as follows: sham-operated normobaric air (21% O-2 at one absolute atmosphere), HBOT only, TBI + normobaric air and TBI + HBOT. Following the evaluation of motor deficits and brain edema, the expression of inflammasome components and effectors was measured by qRT-PCR and Western blotting. Moreover, alterations in IL-1 beta, IL-18 and high-mobility group box 1 (HMGB1) were calculated by enzyme-linked immunosorbent assay at each time point after injury. Results: HBOT improved motor score and reduced brain edema. Furthermore, it suppressed protein expression of inflammasome components and reduced the levels of IL-1 beta and IL-18, accompanied by the reduction of HMGB1 in brain tissues and serum. Conclusion: These results suggest that HBOT may alleviate the inflammatory response after TBI by inhibiting the activation of inflammasome signaling. (C) 2016 S. Karger AG, Basel AD - [Geng, Fengyang; Ma, Yinghua; Xing, Tao; Zhuang, Xianbo; Zhu, Jianxin; Yao, Lusu] Liaocheng Peoples Hosp, Dept Neurosurg, 67 West Dongchang Rd, Liaocheng 252000, Shandong, Peoples R China. Ma, YH (corresponding author), Liaocheng Peoples Hosp, Dept Neurosurg, 67 West Dongchang Rd, Liaocheng 252000, Shandong, Peoples R China. yinghuamalc@sina.com AN - WOS:000377192800007 AU - Geng, F. Y. AU - Ma, Y. H. AU - Xing, T. AU - Zhuang, X. B. AU - Zhu, J. X. AU - Yao, L. S. DO - 10.1159/000445689 J2 - Neuroimmunomodulation KW - Traumatic brain injury Hyperbaric oxygen therapy Inflammasomes High-mobility group box 1 SPINAL-CORD-INJURY CEREBRAL-CORTEX CELL-DEATH EXPRESSION HMGB1 HMGB1/NF-KAPPA-B ACTIVATION PROTEIN MODEL MICE Endocrinology & Metabolism Immunology Neurosciences LA - English M1 - 2 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2016 SN - 1021-7401 SP - 122-129 ST - Effects of Hyperbaric Oxygen Therapy on Inflammasome Signaling after Traumatic Brain Injury T2 - Neuroimmunomodulation TI - Effects of Hyperbaric Oxygen Therapy on Inflammasome Signaling after Traumatic Brain Injury UR - ://WOS:000377192800007 VL - 23 ID - 932026 ER - TY - JOUR AB - OBJECTIVES: The aim of the study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) in participants suffering from chronic neurological deficits due to traumatic brain injury (TBI) of all severities in the largest cohort evaluated so far with objective cognitive function tests and metabolic brain imaging. METHODS: A retrospective analysis was conducted of 154 patients suffering from chronic neurocognitive damage due to TBI, who had undergone computerised cognitive evaluations pre-HBOT and post-HBOT treatment. RESULTS: The average age was 42.7±14.6 years, and 58.4% were men. All patients had documented TBI 0.3-33 years (mean 4.6±5.8, median 2.75 years) prior to HBOT. HBOT was associated with significant improvement in all of the cognitive domains, with a mean change in global cognitive scores of 4.6±8.5 (p<0.00001). The most prominent improvements were in memory index and attention, with mean changes of 8.1±16.9 (p<0.00001) and 6.8±16.5 (p<0.0001), respectively. The most striking changes observed in brain single photon emission computed tomography images were in the anterior cingulate and the postcentral cortex, in the prefrontal areas and in the temporal areas. CONCLUSIONS: In the largest published cohort of patients suffering from chronic deficits post-TBI of all severities, HBOT was associated with significant cognitive improvements. The clinical improvements were well correlated with increased activity in the relevant brain areas. AD - Neurosurgery Department, Galilee Medical Center, Nahariya, Israel. Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, Israel. Galilee Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Research and Development Unit, Assaf Harfoeh Medical Center, Zerifin, Israel. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. AN - 30269074 AU - Hadanny, A. AU - Abbott, S. AU - Suzin, G. AU - Bechor, Y. AU - Efrati, S. C2 - Pmc6169752 DA - Sep 28 DO - 10.1136/bmjopen-2018-023387 DP - NLM ET - 2018/10/01 J2 - BMJ open KW - Adult Brain/diagnostic imaging Brain Injuries, Traumatic/*complications Cognition Disorders/etiology/*therapy Female Humans *Hyperbaric Oxygenation Male Middle Aged Neuropsychological Tests Retrospective Studies Tomography, Emission-Computed, Single-Photon *Hbot *Tbi *cognitive *hyperbaric oxygen *traumatic brain injury LA - eng M1 - 9 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2018 SN - 2044-6055 SP - e023387 ST - Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis T2 - BMJ Open TI - Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis VL - 8 ID - 931843 ER - TY - JOUR AB - Background: Fibromyalgia syndrome (FMS), a condition considered to represent a prototype of central sensitization syndrome, can be induced by different triggers including childhood sexual abuse (CSA). Recent studies have demonstrated hyperbaric oxygen therapy (HBOT) can induce neuroplasticity and improve clinical outcome of FMS. The aim of the current study was to evaluate the effect of HBOT on patients suffering from FMS with a history of CSA. Materials and methods: A prospective randomized clinical trial conducted between July 2015 and November 2017 included women with a history of CSA who fulfilled fibromyalgia diagnosis criteria for at least 5 years prior to inclusion. Included participants (N = 30) were randomly assigned to treatment group, treated with 60 HBOT sessions and a control/crossover group received psychotherapy. After the control period, the control/crossover group was crossed to HBOT. Clinical outcomes were assessed using FMS questioners, post-traumatic stress disorder (PTSD) questioners and quality of life questioners. Objective outcome were assessed using brain function and structure imaging. Findings: Following HBOT, there was a significant improvement in all FMS questionnaires (widespread pain index, Fibromyalgia symptoms severity scale, Fibromyalgia functional impairment), most domains of quality of life, PTSD symptoms and psychological distress. The same significant improvements were demonstrated in the control following crossover to HBOT. Following HBOT, brain SPECT imaging demonstrated significant increase in brain activity in the prefrontal cortex, orbital frontal cortex, and subgenual area (p < 0.05). Brain microstructure improvement was seen by MRI-DTI in the anterior thalamic radiation (p = 0.0001), left Insula (p = 0.001), and the right Thalamus (p = 0.001). Conclusion: HBOT induced significant clinical improvement that correlates with improved brain functionality and brain microstructure in CSA related FMS patients. AD - [Hadanny, Amir; Bechor, Yair; Catalogna, Merav; Efrati, Shai] Assaf Harofeh Med Ctr, Sagol Ctr Hyperbar Med & Res, Zerifin, Israel. [Hadanny, Amir] Bar Ilan Univ, Galilee Fac Med, Ramat Gan, Israel. [Hadanny, Amir; Sigal, Tal; Cohenpour, Mehrzad; Efrati, Shai] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel. [Daphna-Tekoah, Shir; Lev-Wiesel, Rachel] Univ Haifa, Emili Sagol CAT Res Ctr, Haifa, Israel. [Daphna-Tekoah, Shir] Ashkelon Acad Coll, Fac Social Work, Ashqelon, Israel. [Daphna-Tekoah, Shir] Kaplan Med Ctr, Social Work Serv, Rehovot, Israel. [Sigal, Tal] Assaf Harofeh Med Ctr, Radiol Dept, Zerifin, Israel. [Cohenpour, Mehrzad] Assaf Harofeh Med Ctr, Nucl Med Inst, Zerifin, Israel. [Efrati, Shai] Assaf Harofeh Med Ctr, Res & Dev Unit, Zerifin, Israel. [Efrati, Shai] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel. Hadanny, A; Efrati, S (corresponding author), Assaf Harofeh Med Ctr, Sagol Ctr Hyperbar Med & Res, Zerifin, Israel.; Hadanny, A (corresponding author), Bar Ilan Univ, Galilee Fac Med, Ramat Gan, Israel.; Hadanny, A; Efrati, S (corresponding author), Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.; Efrati, S (corresponding author), Assaf Harofeh Med Ctr, Res & Dev Unit, Zerifin, Israel.; Efrati, S (corresponding author), Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel. amir.had@gmail.com; efratishai@outlook.com AN - WOS:000453379800001 AU - Hadanny, A. AU - Bechor, Y. AU - Catalogna, M. AU - Daphna-Tekoah, S. AU - Sigal, T. AU - Cohenpour, M. AU - Lev-Wiesel, R. AU - Efrati, S. C7 - 2495 DA - Dec DO - 10.3389/fpsyg.2018.02495 J2 - Front. Psychol. KW - fibromyalgia childhood sexual abuse FMS CSA PTSD post trauma hyperbaric oxygen HBOT POSTTRAUMATIC-STRESS-DISORDER FORM HEALTH SURVEY POST-CONCUSSION SYNDROME CEREBRAL-BLOOD-FLOW ADULT SURVIVORS PSYCHOLOGICAL TREATMENTS DIFFUSION-TENSOR SURVEY SF-36 BRAIN ABNORMALITIES Psychology, Multidisciplinary LA - English M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2018 SN - 1664-1078 SP - 13 ST - Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse-Randomized Controlled Trial T2 - Frontiers in Psychology TI - Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering From Fibromyalgia With a History of Childhood Sexual Abuse-Randomized Controlled Trial UR - ://WOS:000453379800001 VL - 9 ID - 931998 ER - TY - JOUR AB - INTRODUCTION: Hyperbaric oxygen (HBO₂) therapy is considered to be a generally safe therapy. However, data regarding seizure incidence during HBO₂ therapy as a clinical presentation of central nervous system- (CNS) related oxygen toxicity are conflicting (ranging from 1:10,000 to 1:600 seizures:hyperbaric sessions). The risk for seizures is of significant importance for the growing population of patients suffering from chronic neurological disorders such as traumatic brain injury and stroke who are treated with HBO₂. The aim of this study was to evaluate the incidence of seizures during HBO₂ therapy in a large cohort of patients and determine whether patients with known chronic neurological disorders are at increased risk. METHODS: Retrospective analysis of 2,334 patients treated at the Sagol Center of Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Israel, between June 2010 and December 2014. Patients were grouped into one of three categories according to indication for HBO₂ therapy: Category A--non- neurological indications; Category B--neurological indications; and Category C--acute indications. RESULTS: A total of 62,614 hyperbaric sessions, administered to 2,334 patients, were included in the analysis. The overall incidence of seizures during hyperbaric sessions was 0.011% (1:8,945), occurring in seven (0.3%) patients. Only one patient had a clear oxygen toxicity-induced seizure, with an overall incidence of 1:62,614. CONCLUSIONS: Seizures induced by oxygen toxicity during HBO₂ therapy are extremely rare. Moreover, in relation to oxygen-induced seizures, HBO₂therapy can be considered safe for patients suffering with chronic neurological disorders except for uncontrolled epilepsy. AN - 27000010 AU - Hadanny, A. AU - Meir, O. AU - Bechor, Y. AU - Fishlev, G. AU - Bergan, J. AU - Efrati, S. DA - Jan-Feb DP - NLM ET - 2016/03/24 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adolescent Adult Aged Analysis of Variance Chi-Square Distribution Child Female Humans Hyperbaric Oxygenation/adverse effects/methods/*statistics & numerical data Incidence Israel/epidemiology Male Middle Aged Oxygen/adverse effects Retrospective Studies Risk Assessment Seizures/*epidemiology/etiology LA - eng M1 - 1 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 21-8 ST - Seizures during hyperbaric oxygen therapy: retrospective analysis of 62,614 treatment sessions T2 - Undersea Hyperb Med TI - Seizures during hyperbaric oxygen therapy: retrospective analysis of 62,614 treatment sessions VL - 43 ID - 931863 ER - TY - JOUR AD - Seattle. AN - 28808166 AU - Hampson, N. B. AU - Holm, J. DA - Aug 15 DO - 10.1212/wnl.0000000000004251 DP - NLM ET - 2017/08/16 J2 - Neurology KW - *Brain Concussion *Brain Injuries *Brain Injuries, Traumatic Humans *Hyperbaric Oxygenation Oxygen LA - eng M1 - 7 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2017 SN - 0028-3878 SP - 750 ST - Letter re: Hyperbaric oxygen: B-Level evidence in mild traumatic brain injury clinical trials T2 - Neurology TI - Letter re: Hyperbaric oxygen: B-Level evidence in mild traumatic brain injury clinical trials VL - 89 ID - 931871 ER - TY - JOUR AB - Comments on an article by X. A. Figueroa et al. (see record [rid]2016-46767-018[/rid]). Figueroa et al. reported a reanalysis of hyperbaric oxygen’s effect on mild traumatic brain injury and claimed that oxygen content of arterial blood plasma (oxygen dissolved in plasma) during hyperbaric exposure correlates with treatment response. (PsycINFO Database Record (c) 2017 APA, all rights reserved) AN - 2017-35398-020 AU - Hampson, Neil B. AU - Holm, James DB - APA PsycInfo DO - 10.1212/WNL.0000000000004251 DP - EBSCOhost KW - traumatic brain injury treatment placebo Brain Concussion Medical Treatment (General) M1 - 7 N1 - PsycInfo (EbscoHost) Literature search June 18, 2021 PY - 2017 SN - 0028-3878 1526-632X SP - 750-750 ST - 'Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials': Comment T2 - Neurology TI - 'Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials': Comment UR - http://libproxy.temple.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2017-35398-020&site=ehost-live&scope=site VL - 89 ID - 932037 ER - TY - JOUR AB - BACKGROUND: There is a lack of effective drug for post-stroke dysarthria. Effect of single rehabilitation training is insignificant, and traditional acupuncture and moxibustion therapy obtains good treatment outcomes. OBJECTIVE: To analyze the research focus and prospects of post-stroke dysarthria by bibliometrics, and to explore the treatment efficacy of acupuncture and moxibustion combined with speech-language training for post-stroke dysarthria. METHODS: (1) A computer-based online research of CNKI database for the articles addressing post-stroke dysarthria from January 2004 to December 2018. The distribution of publication year, author, affiliation and funding in the literature was analyzed by group-level browsing and visualization tool. After reading the title and abstract, the review and the articles about nursing and radiography were excluded, and the articles concerning acupuncture and moxibustion were included to summarize acupuncture and moxibustion in the treatment of post-stroke dysarthria. (2) Ninety-six patients with post-stroke dysarthria admitted at the First People’s Hospital of Shenyang between June 2013 and August 2015 were enrolled, and then divided into control and treatment groups (n=48 per group). The control group underwent speech-language training, and the treatment group received speech-language training and acupuncture and moxibustion (acupuncture at tongue and neck), for two courses and 40 days in total. The clinical efficacy was evaluated by advanced Frenchay dysarthria assessment, and the adverse reactions were recorded. RESULTS AND CONCLUSION: (1) One hundred and twenty-one Chinese articles were retrieved. There was 1 article published in 2004, total 14 articles by the end of 2018. The articles (n=5) are mainly form Chengdu University of Traditional Chinese Medicine by Hu Kaming team. Sixty percent of the first ten affiliations and the first eight authors were form the Chinese Medicine Universities or their affiliated hospitals. Of them, 72 articles addressed acupuncture and moxibustion, including 7 in acupuncture at tongue, 8 in acupuncture at tongue and neck, 7 in acupuncture at tongue and head, 12 in acupuncture and electrostimulation, 3 in acupuncture and hyperbaric oxygen therapy, and 35 in acupuncture and rehabilitation training. (2) The total effctiveness rate in the treatment group (92%) was significantly higher than that in the control group (54%) (P < 0.05). In summary, in China, studies on the treatment of post-stroke dysarthria are mainly from Chinese Medicine Universities and their affiliated hospitals. Chinese medicine, especially acupuncture and moxibustion (acupuncture at tongue and neck mostly used) is an important means in the treatment of post-stroke dysarthria. Clinical trial results suggest that post-stroke dysarthria treated by acupuncture at tongue and neck combined with speech-language training can obtain satisfactory outcomes. AD - J. Han, Department of Rehabilitation, The First People’s Hospital of Shenyang, Shenyang, Liaoning Province, China AU - Han, J. DB - Embase DO - 10.3969/j.issn.2095-4344.1119 KW - acupuncture article bibliometrics brain ischemia clinical effectiveness controlled study dysarthria electrostimulation fever human hyperbaric oxygen therapy language disability major clinical study moxibustion oxygen therapy patient satisfaction pseudobulbar palsy speech therapy traumatic brain injury LA - Chinese M1 - 7 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2019 SN - 2095-4344 SP - 1013-1017 ST - Post-stroke dysarthria treated by acupuncture combined with speech-language training: Bibliometric analysis and verification of clinical efficacy T2 - Chinese Journal of Tissue Engineering Research TI - Post-stroke dysarthria treated by acupuncture combined with speech-language training: Bibliometric analysis and verification of clinical efficacy UR - https://www.embase.com/search/results?subaction=viewrecord&id=L2004213785&from=export http://dx.doi.org/10.3969/j.issn.2095-4344.1119 VL - 23 ID - 931899 ER - TY - JOUR AB - Mild traumatic brain injury (TBI) persistent post-concussion syndrome (PPCS) and post-traumatic stress disorder (PTSD) are epidemic in United States Iraq and Afghanistan War veterans. Treatment of the combined diagnoses is limited. The aim of this study is to assess safety, feasibility, and effectiveness of hyperbaric oxygen treatments (HBOT) for mild TBI PPCS and PTSD. Thirty military subjects aged 18-65 with PPCS with or without PTSD and from one or more blast-induced mild-moderate traumatic brain injuries that were a minimum of 1 year old and occurred after 9/11/2001 were studied. The measures included symptom lists, physical exam, neuropsychological and psychological testing on 29 subjects (1 dropout) and SPECT brain imaging pre and post HBOT. Comparison was made using SPECT imaging on 29 matched Controls. Side effects (30 subjects) experienced due to the HBOT: reversible middle ear barotrauma (n = 6), transient deterioration in symptoms (n = 7), reversible bronchospasm (n = 1), and increased anxiety (n = 2; not related to confinement); unrelated to HBOT: ureterolithiasis (n = 1), chest pain (n = 2). Significant improvement (29 subjects) was seen in neurological exam, symptoms, intelligence quotient, memory, measures of attention, dominant hand motor speed and dexterity, quality of life, general anxiety, PTSD, depression (including reduction in suicidal ideation), and reduced psychoactive medication usage. At 6-month follow-up subjects reported further symptomatic improvement. Compared to Controls the subjects' SPECT was significantly abnormal, significantly improved after 1 and 40 treatments, and became statistically indistinguishable from Controls in 75% of abnormal areas. HBOT was found to be safe and significantly effective for veterans with mild to moderate TBI PPCS with PTSD in all four outcome domains: clinical medicine, neuropsychology, psychology, and SPECT imaging. Veterans also experienced a significant reduction in suicidal ideation and reduction in psychoactive medication use. AD - P. Harch, Louisiana State University, School of Medicine, New Orleans, LA, United States AU - Harch, P. AU - Andrews, S. AU - Fogarty, E. AU - Lucarini, J. AU - Van Meter, K. DB - Embase DO - 10.4103/2045-9912.215745 KW - NCT00760734 adult aged anxiety article attention barotrauma blast injury bronchospasm case control study clinical article clinical effectiveness controlled study depression deterioration disease severity drug use ear injury female follow up human hyperbaric oxygen therapy intelligence quotient male memory motor performance postconcussion syndrome posttraumatic stress disorder priority journal prospective study quality of life risk assessment single photon emission computed tomography symptomatology thorax pain traumatic brain injury ureter stone veteran LA - English M1 - 3 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 2045-9912 SP - 156-174 ST - Case control study: Hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder T2 - Medical Gas Research TI - Case control study: Hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder UR - https://www.embase.com/search/results?subaction=viewrecord&id=L618960852&from=export http://dx.doi.org/10.4103/2045-9912.215745 VL - 7 ID - 931913 ER - TY - JOUR AB - Persistent postconcussion syndrome (PPCS) after mild traumatic brain injury (mTBI) is a significant public health and military problem for which there is limited treatment evidence. The aim of this study was to determine whether forty 150 kPa hyperbaric oxygen therapies (HBOTs) can improve symptoms and cognitive function in subjects with the PPCS of mTBI, using a randomized controlled crossover design with 2-month follow-up. Sixty-three civilian and military subjects with mTBI/PPCS were randomized to either 40 HBOTs at 150 kPa/60 minutes, once daily, 5 days per week in 8 weeks or an equivalent no-treatment control period. The Control Group was then crossed over to HBOT. Subjects underwent symptom, neuropsychological, and psychological testing, before and after treatment or control with retesting 2 months after the 40thHBOT. Fifty subjects completed the protocol with primary outcome testing. HBOT subjects experienced significant improvements in Neurobehavioral Symptom Inventory, Memory Index, Automated Neuropsychological Assessment Metrics, Hamilton Depression Scale, Hamilton Anxiety Scale, Post-Traumatic Stress Disorder Checklist, Pittsburgh Sleep Quality Index, and Quality Of Life after Brain Injury compared to the Control Group. After crossing over to HBOT the Control Group experienced near-identical significant improvements. Further improvements were experienced by both groups during the 2-month follow-up period. These data indicate that 40 HBOTs at 150 kPa/60 minutes demonstrated statistically significant improvements in postconcussion and Post-Traumatic Stress Disorder symptoms, memory, cognitive functions, depression, anxiety, sleep, and quality of life in civilian and military subjects with mTBI/PPCS compared to controls. Improvements persisted at least 2 months after the 40thHBOT. The study was registered on ClinicalTrials.gov (NCT02089594) on March 18, 2014 and with the U.S. Food and Drug Administration under Investigational New Drug #113823. The Institutional Review Boards of the United States Army Medical Research and Materiel Command Office of Research Protections Human Research Protection Office and the Louisiana State University School of Medicine (approval No. 7381) approved the study on May 13, 2014 and December 20, 2013, respectively. AD - P. Harch, Department of Medicine, Section of Emergency and Hyperbaric Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, United States AU - Harch, P. AU - Andrews, S. AU - Rowe, C. AU - Lischka, J. AU - Townsend, M. AU - Yu, Q. AU - Mercante, D. DB - Embase Medline DO - 10.4103/2045-9912.279978 KW - NCT02089594 adult article Automated Neuropsychological Assessment Metrics clinical article clinical effectiveness cognition controlled study crossover procedure disease severity female follow up Hamilton Anxiety Scale Hamilton Depression Rating Scale human hyperbaric oxygen therapy male memory assessment Memory Index mental disease assessment military personnel Neurobehavioral Symptom Inventory neuropsychological test Pittsburgh Sleep Quality Index posttraumatic stress disorder checklist postconcussion syndrome priority journal psychologic test Quality Of Life after Brain Injury quality of life assessment randomized controlled trial traumatic brain injury treatment duration treatment outcome LA - English M1 - 1 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2020 SN - 2045-9912 SP - 8-20 ST - Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: A randomized controlled trial T2 - Medical Gas Research TI - Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: A randomized controlled trial UR - https://www.embase.com/search/results?subaction=viewrecord&id=L632220749&from=export http://dx.doi.org/10.4103/2045-9912.279978 VL - 10 ID - 931883 ER - TY - JOUR AB - Mild traumatic brain injury (TBI) persistent post-concussion syndrome (PPCS) and post-traumatic stress disorder (PTSD) are epidemic in United States Iraq and Afghanistan War veterans. Treatment of the combined diagnoses is limited. The aim of this study is to assess safety, feasibility, and effectiveness of hyperbaric oxygen treatments (HBOT) for mild TBI PPCS and PTSD. Thirty military subjects aged 18-65 with PPCS with or without PTSD and from one or more blast-induced mild-moderate traumatic brain injuries that were a minimum of 1 year old and occurred after 9/11/2001 were studied. The measures included symptom lists, physical exam, neuropsychological and psychological testing on 29 subjects (1 dropout) and SPECT brain imaging pre and post HBOT. Comparison was made using SPECT imaging on 29 matched Controls. Side effects (30 subjects) experienced due to the HBOT: reversible middle ear barotrauma (n = 6), transient deterioration in symptoms (n = 7), reversible bronchospasm (n = 1), and increased anxiety (n = 2; not related to confinement); unrelated to HBOT: ureterolithiasis (n = 1), chest pain (n = 2). Significant improvement (29 subjects) was seen in neurological exam, symptoms, intelligence quotient, memory, measures of attention, dominant hand motor speed and dexterity, quality of life, general anxiety, PTSD, depression (including reduction in suicidal ideation), and reduced psychoactive medication usage. At 6-month follow-up subjects reported further symptomatic improvement. Compared to Controls the subjects' SPECT was significantly abnormal, significantly improved after 1 and 40 treatments, and became statistically indistinguishable from Controls in 75% of abnormal areas. HBOT was found to be safe and significantly effective for veterans with mild to moderate TBI PPCS with PTSD in all four outcome domains: clinical medicine, neuropsychology, psychology, and SPECT imaging. Veterans also experienced a significant reduction in suicidal ideation and reduction in psychoactive medication use. AD - Louisiana State University School of Medicine, New Orleans, LA, USA. University of North Dakota School of Medicine, Bismarck, ND, USA. AN - 29152209 AU - Harch, P. G. AU - Andrews, S. R. AU - Fogarty, E. F. AU - Lucarini, J. AU - Van Meter, K. W. C2 - Pmc5674654 DA - Jul-Sep DO - 10.4103/2045-9912.215745 DP - NLM ET - 2017/11/21 J2 - Medical gas research KW - brain injury treatment cognitive assessment combat veterans hyperbaric oxygen persistent post concussion syndrome post traumatic stress disorder single photon emission computed tomography traumatic brain injury He derives income from the treatment facility that is the primary location of his medical practice. He is on the board of directors of the International Hyperbaric Medical Association, a non-profit professional organization, and derives no income from this organization. Dr. Fogarty is president of the International Hyperbaric Medical Foundation (IHMF), a non-profit corporation that promotes education, research, and teaching in hyperbaric medicine. He also owns a holding company for a mobile hyperbaric clinic. Dr. Andrews has no competing financial interests. Juliette Lucarini, is co-owner of the hyperbaric consulting company with Paul G. Harch, M.D. Dr. Van Meter owns a hyperbaric equipment leasing company and contracts with hospitals to provide hyperbaric medicine physician staffing. Dr. Van Meter also owns the treatment facility. Partial presentation of a small subset of data at HBOT 2014 (The 9th International Symposium on Hyperbaric Oxygenation: Roadmap for the Future). Presented two slides on P values for the cognitive and quality of life outcomes for the first 24 subjects, compared to the first 15 subjects, in a lecture on review of the science and literature of HBOT in persistent post-concussion syndrome. None of the imaging, demographics, and content of the tables in this manuscript were presented at that meeting. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2017 SN - 2045-9912 (Print) 2045-9912 SP - 156-174 ST - Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder T2 - Med Gas Res TI - Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder VL - 7 ID - 931862 ER - TY - JOUR AB - Persistent postconcussion syndrome (PPCS) after mild traumatic brain injury (mTBI) is a significant public health and military problem for which there is limited treatment evidence. The aim of this study was to determine whether forty 150 kPa hyperbaric oxygen therapies (HBOTs) can improve symptoms and cognitive function in subjects with the PPCS of mTBI, using a randomized controlled crossover design with 2-month follow-up. Sixty-three civilian and military subjects with mTBI/PPCS were randomized to either 40 HBOTs at 150 kPa/60 minutes, once daily, 5 days per week in 8 weeks or an equivalent no-treatment control period. The Control Group was then crossed over to HBOT. Subjects underwent symptom, neuropsychological, and psychological testing, before and after treatment or control with retesting 2 months after the 40(th) HBOT. Fifty subjects completed the protocol with primary outcome testing. HBOT subjects experienced significant improvements in Neurobehavioral Symptom Inventory, Memory Index, Automated Neuropsychological Assessment Metrics, Hamilton Depression Scale, Hamilton Anxiety Scale, Post-Traumatic Stress Disorder Checklist, Pittsburgh Sleep Quality Index, and Quality Of Life after Brain Injury compared to the Control Group. After crossing over to HBOT the Control Group experienced near-identical significant improvements. Further improvements were experienced by both groups during the 2-month follow-up period. These data indicate that 40 HBOTs at 150 kPa/60 minutes demonstrated statistically significant improvements in postconcussion and Post-Traumatic Stress Disorder symptoms, memory, cognitive functions, depression, anxiety, sleep, and quality of life in civilian and military subjects with mTBI/PPCS compared to controls. Improvements persisted at least 2 months after the 40(th) HBOT. The study was registered on ClinicalTrials.gov (NCT02089594) on March 18, 2014 and with the U.S. Food and Drug Administration under Investigational New Drug #113823. The Institutional Review Boards of the United States Army Medical Research and Materiel Command Office of Research Protections Human Research Protection Office and the Louisiana State University School of Medicine (approval No. 7381) approved the study on May 13, 2014 and December 20, 2013, respectively. AD - Department of Medicine, Section of Emergency and Hyperbaric Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Department of Medicine and Psychiatry, School of Medicine, Louisiana State University Health Sciences Center, Metairie, LA, USA. CaTS Clinical Translational Unit, Tulane University School of Medicine, LA, New Orleans, LA, USA. Family Physicians Center, Marrero, LA, USA. Louisiana State University-Ochsner Psychiatry Residency Training Program, Department of Psychiatry, Louisiana State University Health Sciences Center, New Orleans, LA, USA. School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA. AN - 32189664 AU - Harch, P. G. AU - Andrews, S. R. AU - Rowe, C. J. AU - Lischka, J. R. AU - Townsend, M. H. AU - Yu, Q. AU - Mercante, D. E. C2 - Pmc7871939 DA - Jan-Mar DO - 10.4103/2045-9912.279978 DP - NLM ET - 2020/03/20 J2 - Medical gas research KW - Adult Aged Brain Injuries, Traumatic/*complications Female Humans *Hyperbaric Oxygenation/adverse effects Male Middle Aged Post-Concussion Syndrome/*complications/*therapy Treatment Outcome Young Adult *chronic brain injury *hyperbaric oxygen therapy *neurobehavioral symptom inventory *neuropsychological testing *neurorehabilitation *persistent postconcussion syndrome *post-traumatic stress disorder *randomized controlled trial *symptoms *traumatic brain injury LA - eng M1 - 1 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2020 SN - 2045-9912 SP - 8-20 ST - Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial T2 - Med Gas Res TI - Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial VL - 10 ID - 931836 ER - TY - JOUR AD - Emmes, Rockville, Maryland U.S. Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain LDS Hospital, Salt Lake City, Utah U.S. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah U.S. AN - 31394593 AU - Hart, B. B. AU - Weaver, L. K. AU - Wilson, S. H. AU - Lindblad, A. S. AU - Churchill, S. AU - Deru, K. DA - BIMA Special Edition No. Feb DP - NLM ET - 2019/08/09 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Anxiety/physiopathology Auditory Diseases, Central/physiopathology Brain Concussion/complications/metabolism Depression/physiopathology Eye Movement Measurements Follow-Up Studies Humans *Hyperbaric Oxygenation/adverse effects/methods Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Military Personnel Neuropsychological Tests Post-Concussion Syndrome/etiology/metabolism/*therapy Randomized Controlled Trials as Topic Stress Disorders, Post-Traumatic/etiology/*therapy Systematic Reviews as Topic United States United States Department of Defense submission. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 1066-2936 (Print) 1066-2936 SP - 221-226 ST - Executive summary: Secondary analyses of DoD-sponsored studies examining hyperbaric oxygen for persistent post-concussive symptoms after mild traumatic brain injury T2 - Undersea Hyperb Med TI - Executive summary: Secondary analyses of DoD-sponsored studies examining hyperbaric oxygen for persistent post-concussive symptoms after mild traumatic brain injury VL - 46 ID - 931867 ER - TY - JOUR AB - To date, several Department of Defense (DoD) and civilian studies have evaluated hyperbaric oxygen for mild forms of traumatic brain injury. Prior to the DoD-sponsored "Brain Injury and Mechanisms of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA)" trial, none included post-intervention follow-up beyond three to six months. Post-hoc attempts at long-term follow-up were complicated by low participation and potential self-selection bias. BIMA planned for follow-up through 12 months but was amended to add post-concussive and post-traumatic stress disorder, quality of life, pain, depression, anxiety, and alcohol use assessments at 24 and 36 months. A total of 42 of 71 BIMA participants consented to extendedfollow-up, and 40 and 14 completed a 24- or 36-month visit, respectively, representing an overall response rate of 59% and 20%. Participants who completed extended follow-up were similar to the study group that did not in terms of demographics, perceived intervention allocation, and initial response to intervention. There were no significant differences at 24 or 36 months between intervention groups, and group mean scores were near pre-intervention values. This return to baseline could be due to waning treatment effect, selection bias, or participant or perception effects. Though BIMA implemented several participant retention strategies, more frequent participant contact and increased compensation might improve long-term retention in future studies. clinicaltrials.gov Identifier NCT01611194. AD - Emmes, Rockville, Maryland U.S. Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain LDS Hospital, Salt Lake City, Utah U.S. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah U.S. AN - 31394601 AU - Hart, B. B. AU - Wilson, S. H. AU - Churchill, S. AU - Deru, K. AU - Weaver, L. K. AU - Minnakanti, M. AU - Lindblad, A. S. DA - BIMA Special Edition No. Feb DP - NLM ET - 2019/08/09 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Brain Concussion/complications Double-Blind Method Female Follow-Up Studies Humans *Hyperbaric Oxygenation Male Military Personnel Patient Selection Post-Concussion Syndrome/complications/drug therapy/*therapy Quality of Life Self Report Stress Disorders, Post-Traumatic/complications/drug therapy/*therapy Symptom Assessment Time Factors Treatment Outcome hyperbaric oxygenation extended follow-up mild traumatic brain injury post-concussive syndrome submission. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 1066-2936 (Print) 1066-2936 SP - 313-327 ST - Extended follow-up in a randomized trial of hyperbaric oxygen for persistent post-concussive symptoms T2 - Undersea Hyperb Med TI - Extended follow-up in a randomized trial of hyperbaric oxygen for persistent post-concussive symptoms VL - 46 ID - 931839 ER - TY - JOUR AB - Clinical Scenario: Concussions are a prevalent topic in medicine. Concussion symptoms include headaches, dizziness, nausea, neuropsychiatric symptoms, and cognitive impairments, the persistence of which is referred to as postconcussion syndrome. Hyperbaric oxygen therapy (HBOT) has been proposed and evaluated as an additional treatment of these symptoms. HBOT is an innovative approach that has been considered by many but has received both criticism and acceptance. CLINICAL QUESTION: Is HBOT an effective means of reducing symptoms for individuals suffering from postconcussion syndrome (persistence of symptoms for >3 mo)? Summary of Search: The literature was searched for studies that were relevant to the clinical question. Literature provided 5 level 1 studies that were relevant enough to be considered. Clinical Bottom Line: Based on the research that is available, the authors conclude that there is more evidence to refute the use of HBOT for postconcussion syndrome than to support it. Strength of Recommendation: Four studies disprove the use of HBOT; 1 study supported the use of HBOT. These 5 studies are the same level of evidence (level 1) and provide significant findings in their studies. The strength of this recommendation is a B according to the Centre for Evidence-Based Medicine. AU - Hawkins, J. R. AU - Gonzalez, K. E. AU - Heumann, K. J. DB - Medline DO - 10.1123/jsr.2015-0087 KW - evidence based medicine human hyperbaric oxygen therapy postconcussion syndrome randomized controlled trial (topic) LA - English M1 - 3 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 1543-3072 SP - 290-294 ST - The Effectiveness of Hyperbaric Oxygen Therapy as a Treatment for Postconcussion Symptoms T2 - Journal of sport rehabilitation TI - The Effectiveness of Hyperbaric Oxygen Therapy as a Treatment for Postconcussion Symptoms UR - https://www.embase.com/search/results?subaction=viewrecord&id=L621369638&from=export http://dx.doi.org/10.1123/jsr.2015-0087 VL - 26 ID - 931917 ER - TY - JOUR AB - Traumatic brain injury (TBI) is the greatest cause of death and severe disability in young adults; its incidence is increasing in the elderly and in the developing world. Outcome from severe TBI has improved dramatically as a result of advancements in trauma systems and supportive critical care, however we remain without a therapeutic which acts directly to attenuate brain injury. Recognition of secondary injury and its molecular mediators has raised hopes for such targeted treatments. Unfortunately, over 30 late-phase clinical trials investigating promising agents have failed to translate a therapeutic for clinical use. Numerous explanations for this failure have been postulated and are reviewed here. With this historical context we review ongoing research and anticipated future trends which are armed with lessons from past trials, new scientific advances, as well as improved research infrastructure and funding. There is great hope that these new efforts will finally lead to an effective therapeutic for TBI as well as better clinical management strategies. AD - M.R. Bullock, Neurotrauma, Department of Neurosurgery, Miller School of Medicine, Lois Pope LIFE Center, University of Miami, 1095 NW 14th Terrace, Miami, FL, United States AU - Hawryluk, G. W. J. AU - Bullock, M. R. C1 - bradycor cerestat cp 101 606 nnz 2566 snx 111 DB - Embase Medline DO - 10.1016/j.nec.2016.05.002 KW - NCT00805818 NCT00957671 NCT01058395 NCT01212679 NCT01573507 NCT01825044 NCT01851083 NCT02028104 4 phosphonomethylpipecolic acid aptiganel calcium cyclosporine deltibant dexamethasone dexanabinol eliprodil glutamate receptor antagonist lactic acid magnesium magnesium sulfate methylprednisolone minocycline nimodipine omega conotoxin MVIIA oxygen pegorgotein placebo progesterone recombinant growth hormone recombinant nerve growth factor tempol tirilazad tranexamic acid traxoprodil triamcinolone trofinetide trometamol unindexed drug brain concussion calcium cell level cause of death clinical practice clinical trial (topic) controlled clinical trial (topic) decompressive craniectomy developing country disability severity disease classification disorders of mitochondrial functions drug efficacy drug fatality drug megadose drug safety evidence based medicine excitotoxicity geriatric patient Glasgow coma scale Glasgow outcome scale human hyperbaric oxygen therapy hypoxic ischemic encephalopathy induced hypothermia injury severity intensive care intracranial hypertension morbidity mortality nerve cell necrosis nervous system inflammation neuropathology neuroprotection nonhuman outcome assessment phase 2 clinical trial (topic) phase 3 clinical trial (topic) practice guideline priority journal prognosis randomized controlled trial (topic) review sample size spinal cord injury statistical model stem cell transplantation study design traumatic brain injury bradycor cerestat cp 101 606 nnz 2566 snx 111 LA - English M1 - 4 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1558-1349 1042-3680 SP - 375-396 ST - Past, Present, and Future of Traumatic Brain Injury Research T2 - Neurosurgery Clinics of North America TI - Past, Present, and Future of Traumatic Brain Injury Research UR - https://www.embase.com/search/results?subaction=viewrecord&id=L612668173&from=export http://dx.doi.org/10.1016/j.nec.2016.05.002 VL - 27 ID - 931925 ER - TY - JOUR AB - Direct traumatic optic neuropathy (TON) is a devastating condition and clinical challenge. Its adequate treatment remains controversial. Hyperbaric oxygen (HBO2) therapy has been proposed as an adjunctive treatment for eye disease but has rarely been used in optic neuropathy. The patient was a 57-year-old woman who had direct TON and brain injury after contusion injury. After receiving delayed HBO2 therapy her visual acuity got better - from hand motion to 6/60 - along with improvement of visual field and color vision. She was treated at 2.5 atmospheres absolute for 100 minutes, five times a week, for a total of 61 sessions. Our case highlights that HBO2 may be beneficial as an alternative treatment for direct TON, particularly when combined with brain injury. Although this entity is promising, further randomized controlled trials will be needed to clarify the efficacy of HBO2 in the treatment of direct TON. AD - Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China. AN - 30241127 AU - Hsieh, Y. H. AU - Liang, C. M. AU - Tai, M. C. AU - Chen, Y. J. DA - Jul-Aug DP - NLM ET - 2018/09/22 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Brain Contusion/*complications Female Humans Hyperbaric Oxygenation/*methods Middle Aged Optic Nerve Diseases/etiology/*therapy Optic Nerve Injuries/*complications/diagnostic imaging Treatment Outcome hyperbaric oxygen therapy traumatic optic neuropathy submission. LA - eng M1 - 4 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2018 SN - 1066-2936 (Print) 1066-2936 SP - 463-471 ST - Benefit of hyperbaric oxygen therapy treatment in direct traumatic optic neuropathy: case report T2 - Undersea Hyperb Med TI - Benefit of hyperbaric oxygen therapy treatment in direct traumatic optic neuropathy: case report VL - 45 ID - 931870 ER - TY - JOUR AB - Traumatic brain injury (TBI) is a serious public health problem in the United States. Survivors of TBI are often left with significant cognitive, behavioral, and communicative disabilities. So far there is no effective treatment/intervention in the daily clinical practice for TBI patients. The protective effects of hyperbaric oxygen therapy (HBOT) have been proved in stroke; however, its efficiency in TBI remains controversial. In this review, we will summarize the results of HBOT in experimental and clinical TBI, elaborate the mechanisms, and bring out our current understanding and opinions for future studies. AD - J. Zhang, Departments of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, United States AU - Hu, Q. AU - Manaenko, A. AU - Xu, T. AU - Guo, Z. AU - Tang, J. AU - Zhang, J. DB - Embase DO - 10.4103/2045-9912.184720 KW - caspase 3 gelatinase B heme oxygenase 1 immunoglobulin enhancer binding protein interleukin 10 interleukin 8 nuclear factor I toll like receptor 4 tumor necrosis factor angiogenesis apoptosis clinical effectiveness clinical study clinical trial (topic) down regulation experimental study gene expression regulation human hyperbaric oxygen therapy inflammation intracranial pressure meta analysis (topic) nervous system development neuroprotection nonhuman priority journal protein expression randomized controlled trial (topic) review therapy effect tissue oxygenation traumatic brain injury upregulation LA - English M1 - 2 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 2045-9912 SP - 102-110 ST - Hyperbaric oxygen therapy for traumatic brain injury: Bench-to-bedside T2 - Medical Gas Research TI - Hyperbaric oxygen therapy for traumatic brain injury: Bench-to-bedside UR - https://www.embase.com/search/results?subaction=viewrecord&id=L611346095&from=export http://dx.doi.org/10.4103/2045-9912.184720 VL - 6 ID - 931941 ER - TY - GEN AB - Background. Recent studies have shown that preconditioning with hyperbaric oxygen (HBO) can reduce ischemic and hemorrhagic brain injury. We investigated effects of HBO preconditioning on traumatic brain injury (TBI) at high altitude and examined the role of matrix metalloproteinase-9 (MMP-9) in such protection. Methods. Rats were randomly divided into 3 groups: HBO preconditioning group (HBOP; n=13), high-altitude group (HA; n=13), and high-altitude sham operation group (HASO; n=13). All groups were subjected to head trauma by weight-drop device, except for HASO group. HBOP rats received 5 sessions of HBO preconditioning (2.5 ATA, 100% oxygen, 1h daily) and then were kept in hypobaric chamber at 0.6 ATA (to simulate pressure at 4000 m altitude) for 3 days before operation. HA rats received control pretreatment (1 ATA, room air, 1 h daily), then followed the same procedures as HBOP group. HASO rats were subjected to skull opening only without brain injury. Twenty-four hours after TBI, 7 rats from each group were examined for neurological function and brain water content; 6 rats from each group were killed for analysis by H&E staining and immunohistochemistry. Results. Neurological outcome in HBOP group (0.71 ± 0.49) was better than HA group (1.57 ± 0.53; p<0.05). Preconditioning with HBO significantly reduced percentage of brain water content (86.24 ± 0.52 vs. 84.60 ± 0.37; p < 0.01). Brain morphology and structure seen by light microscopy was diminished in HA group, while fewer pathological injuries occurred in HBOP group. Compared to HA group, pretreatment with HBO significantly reduced the number of MMP-9-positive cells (92.25 ± 8.85 vs. 74.42 ± 6.27; p<0.01). Conclusions. HBO preconditioning attenuates TBI in rats at high altitude. Decline in MMP-9 expression may contribute to HBO precon-ditioning-induced protection of brain tissue against TBI. © 2008 Springer-Verlag. AD - H. Feng, Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China AU - Hu, S. L. AU - Hu, R. AU - Li, F. AU - Liu, Z. AU - Xia, Y. Z. AU - Cui, G. Y. AU - Feng, H. C5 - 19066108 DB - Embase Medline DO - 10.1007/978-3-211-09469-3_37 J2 - Acta Neurochir. Suppl. KW - gelatinase B altitude animal experiment animal model animal tissue article brain tissue brain water clinical evaluation controlled study head injury hematocrit hyperbaric oxygen therapy immunohistochemistry male microscopy neurologic examination neuroprotection nonhuman pH rat traumatic brain injury treatment outcome LA - English M1 - (Hu S.L.; Hu R.; Li F.; Liu Z.; Xia Y.Z.; Cui G.Y.; Feng H., fenghua8888@sohu.com) Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2008 SN - 0065-1419 9783211094686 SP - 191-196 ST - Hyperbaric oxygen preconditioning protects against traumatic brain injury at high altitude TI - Hyperbaric oxygen preconditioning protects against traumatic brain injury at high altitude UR - https://www.embase.com/search/results?subaction=viewrecord&id=L359851687&from=export http://dx.doi.org/10.1007/978-3-211-09469-3_37 ID - 931952 ER - TY - GEN AN - NCT00170352 AU - Institute, Hennepin Healthcare Research DA - November KW - Traumatic Brain Injury N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT00170352 PY - 2002 ST - Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury TI - Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury ID - 932052 ER - TY - GEN AN - NCT01430325 AU - Intermountain Health Care, Inc. DA - July KW - Traumatic Brain Injury N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT01430325 PY - 2011 ST - top-diver TI - Test of Chamber Pressure to Divers and Chamber Attendants ID - 932049 ER - TY - GEN AN - NCT00830453 AU - Intermountain Health Care, Inc. AU - Foundation, Deseret DA - November KW - Brain Injury|Sequelae|Stroke|Anoxia|Trauma N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT00830453 PY - 2003 ST - hybobi TI - Hyperbaric Oxygen Therapy in Chronic Stable Brain Injury ID - 932050 ER - TY - JOUR AB - This editorial focuses on the two articles in this issue of Neurology. The article focuses on the effect of hyperbaric oxygen therapy (HBOT) on mild to moderate traumatic brain injury/persistent postconcussion syndrome (mTBI/PPCS) and concluded that HBOT has therapeutic effects on mTBI/PPCS symptoms and can alleviate posttraumatic stress disorder symptoms secondary to a brain injury. (PsycINFO Database Record (c) 2017 APA, all rights reserved) AN - 2017-35398-019 AU - Karam, Chafic AU - Griggs, Robert C. DB - APA PsycInfo DO - 10.1212/WNL.0000000000004250 DP - EBSCOhost KW - symptoms postconcussion syndromes neurology Syndromes M1 - 7 N1 - PsycInfo (EbscoHost) Literature search June 18, 2021 PY - 2017 SN - 0028-3878 1526-632X SP - 750-750 ST - 'Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials': Editors' note T2 - Neurology TI - 'Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials': Editors' note UR - http://libproxy.temple.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2017-35398-019&site=ehost-live&scope=site VL - 89 ID - 932038 ER - TY - JOUR AB - This editorial discusses titrating the dose of oxygen after severe traumatic brain injury in the era of precision medicine. Over the past 40 to 50 years, one has made strides in understanding the molecular underpinnings of oxidative stress and its consequences in severe traumatic brain injury (TBI), including studies at the bench and bedside. The cellular and molecular events appear to be much more orchestrated than random and potentially amenable to either mitigation or exacerbation by therapeutic interventions at the bedside. Concerns over potential deleterious consequences of hyperoxia have long been raised related to oxygen toxicity from free radical reactions in conditions such as acute lung injury and central nervous system sequelae of hyperbaric oxygen exposure, including seizures. Reports in small series on potential deleterious consequences of hyperoxia, including those in the setting of severe TBI, have appeared sporadically in the literature. In the current era, with multi-center databases, electronic medical records, and big data approaches, a number of large studies across the field of critical care medicine have raised the stakes regarding concerns over deleterious consequences of hyperoxia. (PsycINFO Database Record (c) 2019 APA, all rights reserved) AD - Kochanek, Patrick M., Safar Center for Resuscitation Research, Children’s Hospital of Pittsburgh of the University of Pittsburgh School of Medicine, John G. Rangos Research Center, 6th Floor, 4401 Penn Avenue, Pittsburgh, PA, US, 15224 AN - 2017-50228-001 AU - Kochanek, Patrick M. AU - Bayır, Hülya DB - APA PsycInfo DO - 10.1089/neu.2017.5159 DP - EBSCOhost KW - oxygen traumatic brain injury Precision Medicine Seizures Severity (Disorders) M1 - 22 N1 - PsycInfo (EbscoHost) Literature search June 18, 2021 PY - 2017 SN - 0897-7151 1557-9042 SP - 3067-3069 ST - Titrating the dose of oxygen after severe traumatic brain injury in the era of precision medicine T2 - Journal of Neurotrauma TI - Titrating the dose of oxygen after severe traumatic brain injury in the era of precision medicine UR - http://libproxy.temple.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2017-50228-001&site=ehost-live&scope=site kochanekpm@ccm.upmc.edu VL - 34 ID - 932042 ER - TY - JOUR AB - Hyperbaric medicine includes two different medical fields: hyperbaric oxygenation (HBO) as emergency and intensive care, and diving medicine. Recent topics in hyperbaric therapy include radiation oncology and regenerative medicine. Of special interest are clinical studies of radiotherapy after HBO that were conducted at some institutes to evaluate its therapeutic effects for cancer patients. A few studies have shown that HBO improves memory disturbance following traumatic brain injury and hypoxic and ischemic events. There is a great possibility that HBO enhances the therapeutic effects of radiotherapy and potentiates regenerative medicine. Randomized controlled trials, however, have indicated the re-examination of its viable treatment effects in some conditions, including decompression illness, carbon monoxide poisoning, and serious soft tissue infection. As recent trends in the treatment of decompression illness have changed on the basis of clinical series, the laws related to diving and caisson work should be amended in the future. AD - Division of Neurosurgery, Nishinihon Hospital. Department of Environmental Medicine, Kurume University School of Medicine. Division of Surgery and Emergency Medicine, Tamaki Hospital. AN - 33678790 AU - Kohshi, K. AU - Tamaki, H. AU - Ishitake, T. DO - 10.7888/juoeh.43.87 DP - NLM ET - 2021/03/09 J2 - Journal of UOEH KW - clinical issues radiation injury radiotherapy regenerative medicine LA - jpn M1 - 1 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2021 SN - 0387-821X (Print) 0387-821x SP - 87-96 ST - [New Therapeutic Strategies and Future Issues in Hyperbaric Medicine] T2 - J uoeh TI - [New Therapeutic Strategies and Future Issues in Hyperbaric Medicine] VL - 43 ID - 931876 ER - TY - JOUR AB - Objective: To select the combination of treatment parameters of hyperbaric oxygen therapy (hyperoxia) that are most likely to demonstrate improvement in the rate of good functional outcome following severe traumatic brain injury (TBI). Methods: This is a multicenter, prospective, randomized, adaptive phase II clinical trial. Individuals aged 16 to 65 who present to one of 14 enrolling sites with severe TBI (GCS 3 to 8) will be eligible for inclusion. Individuals with GCS of 7 or 8 and a Marshall CT score of 1 or 2, and those with a GCS of 3 and bilaterally mid-position and nonreactive pupils will be excluded. Participants will be randomized to one of 8 interventions and treated for up to 5 days. There will be an initial burn-in period of 53 participants during which participants will be enrolled in a fixed randomization ratio of 6:6:6:6:6:6:6:11. A constant proportion of 20% of participants will be randomized to the control arm throughout the study. After the initial burn-in period, response adaptive randomization (RAR) will be performed. During this period, interim analysis of outcome data will be performed quarterly and the results will be used to adjust randomization probabilities to favor the better performing arms. Hyperoxia treatment will be initiated within 6 hours of hospital presentation for those not requiring craniotomy and within 12 hours of presentation for those requiring craniotomy/other major surgery. The primary outcome is functional recovery measured by a sliding dichotomized Glasgow Outcome Scale Extended (GOS-E) at 6-months post-injury. We will calculate the probability that a treatment arm is both superior to control and has a >50% chance of phase III success. A maximum of 200 subjects will be enrolled during a planned enrollment period of 3 years. Conclusion: The HOBIT trial is designed to determine the most effective treatment parameters for hyperoxia and yield data that will support a clear go/no-go decision regarding whether the hyperoxia should proceed to a phase III trial. AD - F. Korley, University of Michigan Medical School, Emergency Medicine, Ann Arbor, United States AU - Korley, F. AU - Rockswold, G. AU - Gajewski, B. AU - Martin, R. AU - Silbergleit, R. AU - Barsan, W. DB - Embase DO - 10.1089/neu.2017.29011.abstracts KW - adolescent adult aged clinical trial controlled clinical trial controlled study craniotomy female Glasgow outcome scale hospital human hyperbaric oxygen therapy hyperoxia major clinical study major surgery male phase 3 clinical trial probability randomization randomized controlled trial traumatic brain injury LA - English M1 - 13 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 1557-9042 SP - A59-A60 ST - The design of the hyperbaric oxygen brain injury treatment (Hobit) trial T2 - Journal of Neurotrauma TI - The design of the hyperbaric oxygen brain injury treatment (Hobit) trial UR - https://www.embase.com/search/results?subaction=viewrecord&id=L617551714&from=export http://dx.doi.org/10.1089/neu.2017.29011.abstracts VL - 34 ID - 931921 ER - TY - JOUR AB - Background: Disorders of consciousness (DOC) after traumatic brain injury (TBI) raise the mortality of patients, restrict the rehabilitation of patients with TBI, and increase the physical and economic burden that TBI imposes on patients and their families. Thus, treatment to promote early awakening in DOC after TBI is of vital importance. Various treatments have been reported, but there is no advanced evidence base to support them. Transcranial direct current stimulation (tDCS) has shown great potential in promoting neuroelectrochemical effects. This protocol is for a double-blind, randomized, controlled, clinical trial aiming to research the effects and safety of conventional rehabilitation combined with tDCS therapy in patients with DOC after TBI. Methods/design: Eighty patients with DOC after TBI will be randomized into one of two groups receiving conventional rehabilitation combined with sham tDCS or conventional rehabilitation combined with active tDCS. The intervention period in each of the two groups will last 4 weeks (20 min per day, 6 days per week). Primary outcomes (Glasgow Outcome Scale (GOS)) will be measured at baseline and the end of every week from the first to the fourth week. Secondary outcomes will be measured at baseline and the end of the fourth week. Adverse events and untoward effects will be measured during each treatment. Discussion: Patients with central nervous system lesions have received tDCS as a painless, non-invasive, easily applied and effective therapy for several decades, and there has been some evidence in recent years showing partial improvement on the level of consciousness of partial patients with DOC. However, reports mainly focus on the patients in a minimally conscious state (MCS), and there is a lack of large-sample clinical trials. This protocol presents an objective design for a randomized controlled trial that aims to study the effectiveness of conventional rehabilitation combined with tDCS therapy for DOC after TBI, to evaluate its safety, and to explore effective and economical therapeutic methods. Trial registration: Chinese Clinical Trial Registry, ChiCTR1800014808. Registered on 7 February 2018. AD - W. Sun, Department of Rehabilitation Medicine, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China AU - Li, S. AU - Dong, X. AU - Sun, W. AU - Zhao, N. AU - Yu, G. AU - Shuai, L. DB - Embase Medline DO - 10.1186/s13063-019-3680-1 KW - 1800014808 adult aged article clinical effectiveness comparative effectiveness consciousness disorder consciousness level controlled study double blind procedure electroencephalography evoked brain stem auditory response female follow up Glasgow outcome scale human hyperbaric oxygen therapy intervention study kinesiotherapy major clinical study male non invasive procedure outcome assessment passive movement patient safety randomized controlled trial range of motion sensory evoked potential transcranial direct current stimulation traumatic brain injury LA - English M1 - 1 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2019 SN - 1745-6215 ST - Effects of transcranial direct current stimulation on patients with disorders of consciousness after traumatic brain injury: Study protocol for a randomized, double-blind controlled trial T2 - Trials TI - Effects of transcranial direct current stimulation on patients with disorders of consciousness after traumatic brain injury: Study protocol for a randomized, double-blind controlled trial UR - https://www.embase.com/search/results?subaction=viewrecord&id=L629638452&from=export http://dx.doi.org/10.1186/s13063-019-3680-1 VL - 20 ID - 931887 ER - TY - JOUR AB - By observing the dynamic changes of extracellular histones H1, H2A, H4, and NF-κB expression in brain tissues after brain injury in rats, we explore the association among the expression of extracellular histones H1, H2A, H4, and NF-κB following traumatic brain injury (TBI), as well as the effect of different atmospheres absolute hyperbaric oxygen (HBO) intervention on the expression and possible mechanisms. A total of 120 SD rats were randomly divided into 4 groups: Sham-operated (SH), TBI (traumatic brain injury) group, traumatic brain injury and hyperbaric oxygen treatment 1.6ATA (TBI + HBO1) group, and traumatic brain injury and hyperbaric oxygen treatment2.2ATA (TBI + HBO2) group, with 30 rats in each group. The rats in each group were then randomly divided into five smaller time-specific sub-groups: 3 h, 6 h, 12 h, 24 h, and 48 h after surgery. TBI models were established, and the brain tissue around the lesion was taken at different time points. On the one hand,we detected the level of local histones H1, H2A, H4, and NF-κB by RT-PCR and Western Blot. On the other hand, we used immunohistochemical methods to detect the expression of NF-κB, while using the TUNEL method to observe the cell apoptosis in experimental groups after brain injury. Extracellular histones H1, H2A, H4, and NF-κB proteins were highly expressed at 3 h, then with a slight fluctuation, reached to peak at 48 h after the injury. HBO can affect the expression of histones H1, H2A, H4, and NF-κB. The decline of each indicator in the 1.6ATA group was significantly lower than that in the 2.2ATA group, especially within 6 h (P < 0. 05). In addition, NF-κB expression was consistent with the pathological changes of apoptosis in experimental groups. Hyperbaric oxygen therapy with relatively low pressure (1.6ATA) at the early stage can significantly inhibit the expression of extracellular histones H1, H2A, H4, and NF-κB around the lesion, reduce the apoptosis of nerve cells, and thus play an important role in alleviating secondary brain injury. AD - Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Chao-Yang District, Beijing, 100020, China. Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, 8 South Gongti Road, Chao-Yang District, Beijing, 100020, China. JYANG2postgraduate@yeah.net. AN - 32705509 AU - Liang, F. AU - Sun, L. AU - Yang, J. AU - Liu, X. H. AU - Zhang, J. AU - Zhu, W. Q. AU - Yang, L. AU - Nan, D. C2 - Pmc7591663 DA - Nov DO - 10.1007/s12192-020-01137-6 DP - NLM ET - 2020/07/25 J2 - Cell stress & chaperones KW - *Extracellular histones *Hyperbaric oxygen *Traumatic brain injury animals were carried out in strict accordance with the NIH Guide for the Care and Use of Laboratory Animals. LA - eng M1 - 6 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2020 SN - 1355-8145 (Print) 1355-8145 SP - 1013-1024 ST - The effect of different atmosphere absolute hyperbaric oxygen on the expression of extracellular histones after traumatic brain injury in rats T2 - Cell Stress Chaperones TI - The effect of different atmosphere absolute hyperbaric oxygen on the expression of extracellular histones after traumatic brain injury in rats VL - 25 ID - 931859 ER - TY - GEN AB - Because of the rapid industrial and economic growth, Taiwan and other developing countries have faced an enormous increase in the number of motorcycles, which has subsequently caused a rapid increase of the motorcycle-related traumatic brain injuries (TBI). In order to tackle this serious problem, stepwise approaches for TBI were implemented in Taiwan from 1991 to 2007. Step 1 was to do a nationwide TBI registry in order to identify the risk factors and determinants. We found that the major cause of TBI in Taiwan was motorcycle-related injury, and very few motorcyclists wore a helmet. Step 2 was to launch the implementation of the helmet use law on June 1, 1997. A rapid decline of TBI hospitalizations and deaths was demonstrated soon thereafter. Step 3 was to enroll into international collaborations with the Global Spine and Head Injury Prevention Project (Global SHIP Project) groups for TBI. The comparative results thus obtained could be used to develop prevention strategies for developing countries. Step 4 was to implement clinical researches for TBI, which included a Propofol study, hyperbaric oxygen therapy (HBOT), brain parenchymal oxygen (PbtO2) monitoring, etc. Step 5 was to develop guidelines for the management of severe TBI in Taiwan. Through a 2-year period of review, discussion, and integration, a 9-chapter guideline was published in June 2007. In summary, our experience and process for management of TBI in Taiwan can be used as a reference for other developing countries. © 2008 Springer-Verlag. AD - W.-T. Chiu, Department of Neurosurgery, Taipei Medical University, Wan Fang Hospital, 111, Hsing-Long Road, Taipei 116, Taiwan AU - Lin, J. W. AU - Lin, C. M. AU - Tsai, J. T. AU - Hung, K. S. AU - Hung, C. C. AU - Chiu, W. T. C5 - 18642644 DB - Embase Medline DO - 10.1007/978-3-211-78205-7_19 J2 - Acta Neurochir. Suppl. KW - developing country hospitalization human hyperbaric oxygen therapy review Taiwan traffic accident transcutaneous oxygen monitoring traumatic brain injury LA - English M1 - (Lin J.W.; Lin C.M.; Hung K.S.; Hung C.C.; Chiu W.-T., wtchiu@tmu.edu.tw) Department of Neurosurgery, Taipei Medical University, Wan Fang Hospital, 111, Hsing-Long Road, Taipei 116, Taiwan M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2008 SN - 0065-1419 9783211782040 SP - 113-117 ST - Neurotrauma research in Taiwan TI - Neurotrauma research in Taiwan UR - https://www.embase.com/search/results?subaction=viewrecord&id=L359851713&from=export http://dx.doi.org/10.1007/978-3-211-78205-7_19 ID - 931953 ER - TY - GEN AB - Hyperbaric oxygen therapy (HBOT) is the medical therapeutic use of oxygen at a higher atmospheric pressure. The United States Food and Drug Administration have approved several clinical applications for HBOT, but HBOT in traumatic brain injury (TBI) patients has still remained in controversial. The purpose of our study is to evaluate the benefit of HBOT on the prognosis of subacute TBI patients. We prospectively enrolled 44 patients with TBI from November 1, 2004 to October 31, 2005. The study group randomly included 22 patients who received HBOT after the patients' condition stabilization, and the other 22 corresponding condition patients were assigned into the matched control group who were not treated with HBOT. The clinical conditions of the patients were evaluated with the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) before and 3 to 6 months after HBOT. The GCS of the HBOT group was improved from 11.1 to 13.5 in average, and from 10.4 to 11.5 (p<0.05) for control group. Among those patients with GOS = 4 before the HBOT, significant GOS improvement was observed in the HBOT group 6 months after HBOT. Based on this study, HBOT can provide some benefits for the subacute TBI patients with minimal adverse side effects. © 2008 Springer-Verlag. AD - W.-T. Chiu, Department of Neurosurgery, Taipei Medical University, Wan Fang Hospital, 111, Hsing-Long Road, Taipei 116, Taiwan AU - Lin, J. W. AU - Tsai, J. T. AU - Lee, L. M. AU - Lin, C. M. AU - Hung, C. C. AU - Hung, K. S. AU - Chen, W. Y. AU - Wei, L. AU - Ko, C. P. AU - Su, Y. K. AU - Chiu, W. T. C5 - 18642650 DB - Embase Medline DO - 10.1007/978-3-211-78205-7_25 J2 - Acta Neurochir. Suppl. KW - adolescent adult article clinical article controlled study female Glasgow coma scale Glasgow outcome scale human hyperbaric oxygen therapy male otalgia prospective study seizure traumatic brain injury tympanostomy tube LA - English M1 - (Lin J.W.; Lin C.M.; Hung K.S.; Chen W.Y.; Wei L.; Ko C.P.; Su Y.K.; Chiu W.-T., wtchiu@tmu.edu.tw) Department of Neurosurgery, Taipei Medical University, Wan Fang Hospital, 111, Hsing-Long Road, Taipei 116, Taiwan M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2008 SN - 0065-1419 9783211782040 SP - 145-149 ST - Effect of hyperbaric oxygen on patients with traumatic brain injury TI - Effect of hyperbaric oxygen on patients with traumatic brain injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L359851720&from=export http://dx.doi.org/10.1007/978-3-211-78205-7_25 ID - 931954 ER - TY - JOUR AB - Purpose: Eye movements may offer a sensitive method to detect abnormalities and measure response to intervention in mild traumatic brain injury (mTBI). Methods: The Brain Injury and Mechanisms of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury Study (BIMA) randomized 71 participants to 40 daily sessions of hyperbaric oxygen or sham. A companion normative population study enrolled 75 participants. An eye tracking system (EyeLink II, SR Research, Ottawa, Canada) was used to measure eye movements at baseline, 13 weeks and 6 months. Left and right eye movements were recorded for up to 34 parameters for 11 tracking tasks including both saccadic and smooth pursuit. Results were considered significant if t-tests for at least one eye was significant at p<0.001 and the contralateral eye at p<0.02 as confirmatory evidence to informally adjust for multiple testing. Results: All but 5 of the 34 circular test parameters, 4 of the horizontal ramp, 6 of the vertical ramp, and 13 of the reading task had significantly worse performance in the BIMA population compared to the normal population. On average BIMA participants read fewer lines than normative participants (OD: 44.3 versus 47.8 lines, p=0.04), averaged more fixations (OD: 6.9 versus 6.1, p=0.005) and more regressions per line (OD: 3.8 versus 3.1, p=0.0003). At 13 weeks and 6 months, BIMA participants, regardless of intervention, shifted towards the normal population distribution for the circular, and the horizontal and vertical ramp tasks. The reading task continued to suggest abnormalities. There were no differences between the hyperbaric and sham arms in performance at any time point. Conclusions: Circular, horizontal and vertical ramp, and reading tasks were the most sensitive in differentiating between the normative and BIMA participants, suggesting potentially greater vulnerability of the smooth pursuit system to mTBI compared to the saccadic system. Following intervention, BIMA participants on both intervention arms experienced improved performance on the circular, horizontal and vertical ramp tasks such that differences from the normal participants were no longer evident. The improvement did not differ significantly between the two interventions at any post intervention timepoint. AD - A.S. Lindblad, Emmes Corporation, Rockville, MD, United States AU - Lindblad, A. S. AU - Wetzel, P. A. AU - Weaver, L. K. AU - Mulatya, C. AU - Wilson, S. H. AU - Kannan, M. A. AU - Villamar, Z. D. DB - Embase KW - adult Canada conference abstract congenital malformation controlled study eye movement monitor female human hyperbaric oxygen therapy major clinical study male population distribution population research postconcussion syndrome randomized controlled trial reading test smooth pursuit eye movement traumatic brain injury LA - English M1 - 9 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2018 SN - 1552-5783 ST - Eyetracker outcomes in a randomized trial of hyperbaric oxygen or sham in participants with persistent post-concussive symptoms T2 - Investigative Ophthalmology and Visual Science TI - Eyetracker outcomes in a randomized trial of hyperbaric oxygen or sham in participants with persistent post-concussive symptoms UR - https://www.embase.com/search/results?subaction=viewrecord&id=L628536922&from=export VL - 59 ID - 931904 ER - TY - JOUR AB - In the present study, we evaluated the changes in autophagy after hyperbaric oxygen (HBO) treatment for traumatic brain injury (TBI) and investigated whether autophagy takes part in the neuroprotection after HBO treatment. Male Sprague Dawley rats were assigned to four groups randomly: sham injury, sham injury and HBO, TBI, and TBI and HBO. The HBO rats received HBO treatment for 100 min immediately after injury. Rats were sacrificed at 24 h after the brain injury and the levels of cleaved caspase-3 and the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cells in the injured cortex were measured to determine cell death. The expression levels of autophagy-associated proteins were measured by immunohistochemistry and Western blotting to assess changes in autophagy. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cell density and cleaved caspase-3 expression were increased 24 h after TBI. These increases were suppressed by post-TBI HBO treatment. Immunohistochemistry and Western blotting of autophagy-associated proteins showed that TBI can induce autophagy and that HBO treatment can further upregulate the expression of autophagy makers, as shown by an increase in LC3, ATG-5, and Beclin-1 expression and reduction in P62 expression. In conclusion, HBO treatment can reduce apoptosis and further upregulate autophagy in the injured cortex after brain injury, and the autophagy pathway may take part in the neuroprotection provided by HBO treatment for TBI. AD - [Liu, Wen-Chao; Wen, Liang; Wang, Hao; Gong, Jiang-Biao; Zhan, Tian-Xiang; Meng, Yuan-Yuan; Yang, Xiao-Feng] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Neurosurg, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China. Yang, XF (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Neurosurg, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China. zjcswk@126.com AN - WOS:000398614500001 AU - Liu, W. C. AU - Wen, L. AU - Wang, H. AU - Gong, J. B. AU - Zhan, T. X. AU - Meng, Y. Y. AU - Yang, X. F. DO - 10.2147/jn.s119037 J2 - J. Neuroresstoratology KW - autophagy hyperbaric oxygen treatment traumatic brain injury apoptosis neuroprotective effect APOPTOTIC CELL-DEATH HEAD-INJURY THERAPY MICE MODEL BCL-2 DECREASES PHOSPHORYLATION RAPAMYCIN MODERATE Clinical Neurology LA - English M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2017 SN - 2324-2426 SP - 85-91 ST - Neuroprotection of hyperbaric oxygen treatment for traumatic brain injury involving autophagy pathway in rats T2 - Journal of Neurorestoratology TI - Neuroprotection of hyperbaric oxygen treatment for traumatic brain injury involving autophagy pathway in rats UR - ://WOS:000398614500001 VL - 5 ID - 932013 ER - TY - JOUR AB - The pathologic process of chronic phase traumatic brain injury is associated with spreading inflammation, cell death, and neural dysfunction. It is thought that sequestration of inflammatory mediators can facilitate recovery and promote an environment that fosters cellular regeneration. Studies have targeted post-traumatic brain injury inflammation with the use of pharmacotherapy and cell therapy. These therapeutic options are aimed at reducing the edematous and neurodegenerative inflammation that have been associated with compromising the integrity of the blood-brain barrier. Although studies have yielded positive results from anti-inflammatory pharmacotherapy and cell therapy individually, emerging research has begun to target inflammation using combination therapy. The joint use of anti-inflammatory drugs alongside stem cell transplantation may provide better clinical outcomes for traumatic brain injury patients. Despite the promising results in this field of research, it is important to note that most of the studies mentioned in this review have completed their studies using animal models. Translation of this research into a clinical setting will require additional laboratory experiments and larger preclinical trials. AD - C.V. Borlongan, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States AU - Mashkouri, S. AU - Crowley, M. G. AU - Liska, M. G. AU - Corey, S. AU - Borlongan, C. V. DB - Embase DO - 10.4103/1673-5374.191197 KW - ginsenoside mannitol matrix metalloproteinase minocycline progesterone propranolol rosuvastatin simvastatin vasculotropin receptor ziprasidone blood brain barrier feasibility study genotype phenotype correlation human hyperbaric oxygen therapy inflammation intervention study mesenchymal stem cell microglia motor performance nerve fiber regeneration neuroprotection nonhuman polypharmacy research review traumatic brain injury LA - English M1 - 9 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1876-7958 1673-5374 SP - 1379-1384 ST - Utilizing pharmacotherapy and mesenchymal stem cell therapy to reduce inflammation following traumatic brain injury T2 - Neural Regeneration Research TI - Utilizing pharmacotherapy and mesenchymal stem cell therapy to reduce inflammation following traumatic brain injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L613238739&from=export http://dx.doi.org/10.4103/1673-5374.191197 VL - 11 ID - 931929 ER - TY - JOUR AB - BACKGROUND: Dizziness and imbalance are common after mild traumatic brain injury (mTBI). Hyperbaric oxygen (HBO2) has been proposed for persistent post-concussive symptoms after mTBI, but its effect on vestibular function is unknown. OBJECTIVE: To describe balance function in military service-members before and after intervention, and to explore the influence of post-traumatic stress disorder (PTSD), anxiety, and depression on vestibular outcomes. METHODS: Seventy-one participants with mTBI and seventy-five healthy adults without brain injury were enrolled (NCT01611194 and NCT01925963). mTBI participants were randomized to 40 HBO2 sessions or 40 sham chamber sessions over 12 weeks. Normative controls received no intervention. Balance and neuropsychological function were measured at baseline, 13 weeks, and 6 months. RESULTS: The mTBI cohort performed worse than healthy controls on balance and gait measures and reported more affective symptoms. Some within-group improvements were noted at 13 weeks and 6 months. Significant between-intervention differences on balance measures were minimal but effects on postural control generally favored HBO2. Those with affective symptoms, particularly PTSD, had the most improvement in postural control and otolith function following 13 weeks of HBO2. CONCLUSION: HBO2 may influence balance function after mTBI, particularly in those with affective symptoms. AD - Lovelace Biomedical Research, Albuquerque, New Mexico, USA. Emmes, Rockville, MD, USA. Division of Hyperbaric Medicine Intermountain Medical Center, Murray, UT, and Intermountain LDS Hospital, Salt Lake City, UT, USA. Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. AN - 31282447 AU - Meehan, A. AU - Hebert, D. AU - Deru, K. AU - Weaver, L. K. DO - 10.3233/ves-180671 DP - NLM ET - 2019/07/10 J2 - Journal of vestibular research : equilibrium & orientation KW - Adult Affective Symptoms/*etiology Anxiety/complications Case-Control Studies Depression/complications Female Humans Hyperbaric Oxygenation/*statistics & numerical data Longitudinal Studies Male Military Personnel Post-Concussion Syndrome/complications/*therapy Postural Balance/*physiology Stress Disorders, Post-Traumatic/complications *Mild traumatic brain injury *anxiety *computerized dynamic posturography *depression *hyperbaric oxygen *persistent post-concussive symptoms *post-traumatic stress *vestibular evoked myogenic potentials LA - eng M1 - 4 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 0957-4271 SP - 205-219 ST - Longitudinal study of hyperbaric oxygen intervention on balance and affective symptoms in military service members with persistent post-concussive symptoms T2 - J Vestib Res TI - Longitudinal study of hyperbaric oxygen intervention on balance and affective symptoms in military service members with persistent post-concussive symptoms VL - 29 ID - 931842 ER - TY - JOUR AB - BACKGROUND: Dizziness and imbalance are common after mild traumatic brain injury (TBI). Hyperbaric oxygen (HBO2) has been proposed for persistent post‐concussive symptoms after mild TBI, but its effect on vestibular function is unknown. OBJECTIVE: To describe balance function in military service‐members before and after intervention, and to explore the influence of post‐traumatic stress disorder (PTSD), anxiety, and depression on vestibular outcomes. METHODS: Seventy‐one participants with mild TBI and seventy‐five healthy adults without brain injury were enrolled (NCT01611194 and NCT01925963). Mild TBI participants were randomized to 40 HBO2 sessions or 40 sham chamber sessions over 12 weeks. Healthy controls received no intervention. Balance and neuropsychological function were measured at baseline, 13 weeks, and 6 months. RESULTS: The mild TBI cohort performed worse than healthy controls on balance and gait measures and reported more affective symptoms. Some within‐group improvements were noted at 13 weeks and 6 months. Significant between‐intervention differences on balance measures were minimal but effects on postural control generally favored HBO2. Those with affective symptoms, particularly PTSD, had the most improvement in postural control and otolith function following 13 weeks of HBO2. CONCLUSION: HBO2 may influence balance function after mild TBI, particularly in those with affective symptoms. AN - CN-01962400 AU - Meehan, A. AU - Hebert, D. AU - Deru, K. AU - Weaver, L. K. DO - 10.3233/VES-180671 KW - *anxiety *emotional disorder *hyperbaric oxygen therapy *longitudinal study *military service *postconcussion syndrome *posttraumatic stress disorder *stabilography *traumatic brain injury *vestibular evoked myogenic potential Adult Article Cohort analysis Controlled study Depression Dizziness Female Gait Human Major clinical study Male Otolith Randomized controlled trial M3 - Journal: Article in Press N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2019 ST - Longitudinal study of hyperbaric oxygen intervention on balance and affective symptoms in military service members with persistent post-concussive symptoms T2 - Journal of vestibular research TI - Longitudinal study of hyperbaric oxygen intervention on balance and affective symptoms in military service members with persistent post-concussive symptoms UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01962400/full ID - 931969 ER - TY - JOUR AB - Previous studies have reported high rates of auditory and vestibular-balance deficits immediately following head injury. This study uses a comprehensive battery of assessments to characterize auditory and vestibular function in 71 U.S. military service members with chronic symptoms following mild traumatic brain injury that did not resolve with traditional interventions. The majority of the study population reported hearing loss (70%) and recent vestibular symptoms (83%). Central auditory deficits were most prevalent, with 58% of participants failing the SCAN3:A screening test and 45% showing abnormal responses on auditory steady-state response testing presented at a suprathreshold intensity. Only 17% of the participants had abnormal hearing (>25 dB hearing loss) based on the pure-tone average. Objective vestibular testing supported significant deficits in this population, regardless of whether the participant self-reported active symptoms. Composite score on the Sensory Organization Test was lower than expected from normative data (mean 69.6 +/- 15.6). High abnormality rates were found in funduscopy torsion (58%), oculomotor assessments (49%), ocular and cervical vestibular evoked myogenic potentials (46% and 33%, respectively), and monothermal calorics (40%). It is recommended that a full peripheral and central auditory, oculomotor, and vestibular-balance evaluation be completed on military service members who have sustained head trauma. AD - [Meehan, Anna] Lovelace Biomed Res, Albuquerque, NM USA. [Searing, Elizabeth] Henry M Jackson Fdn, Bethesda, MD USA. [Weaver, Lindell K.] Intermt Med Ctr, Div Hyperbar Med, Murray, UT USA. [Weaver, Lindell K.] Intermt LDS Hosp, Salt Lake City, UT USA. [Weaver, Lindell K.] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84132 USA. [Lewandowski, Andrew] Emmes Corp, Rockville, MD USA. Meehan, A (corresponding author), Lovelace Biomed Res, Albuquerque, NM USA. ameehan@lrri.org AN - WOS:000386867300007 AU - Meehan, A. AU - Searing, E. AU - Weaver, L. K. AU - Lewandowski, A. J2 - Undersea Hyperb. Med. KW - vestibular tests vestibulo-ocular reflex central auditory dysfunction mild traumatic brain injury post-concussive symptoms hearing TRAUMATIC BRAIN-INJURY HYPERBARIC-OXYGEN CONSEQUENCES VERTIGO DESIGN Marine & Freshwater Biology Medicine, Research & Experimental LA - English M1 - 5 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2016 SN - 1066-2936 SP - 567-584 ST - Baseline vestibular and auditory findings in a trial of post-concussive syndrome T2 - Undersea and Hyperbaric Medicine TI - Baseline vestibular and auditory findings in a trial of post-concussive syndrome UR - ://WOS:000386867300007 VL - 43 ID - 932023 ER - TY - JOUR AB - Background: The aim of this study was to investigate the effect of hyperbaric oxygen therapy on the Akt signaling pathway in the brain tissue around the injured area following traumatic brain injury in rats. Methods: The modified Feeney freefall method was applied to establish a rat model of traumatic brain injury. Sixty male SD rats were randomly divided into three groups: a sham operation group, a traumatic brain injury group and a hyperbaric oxygen therapy after traumatic brain injury group. At 12 and 24 hours after the injury was introduced, the neurological function score was evaluated. Western blot and immunohistochemistry assays were carried out to detect the expression of pAkt, cleaved caspase-3 and Bcl-2 in the cortex around the injured area 24 hours after brain injury, and immunohistochemistry assays were performed to detect the expression of pAkt and cleaved caspase-3 in the brain tissue around the injured area. The TUNEL assay was conducted to detect apoptosis of neuronal cells 24 hours after the trauma. Results: Hyperbaric oxygen therapy significantly increased the expression of pAkt (P<0.001), inhibited the expression of cleaved caspase-3 in the brain tissue around the injured area after traumatic brain injury (P<0.001), enhanced the expression of the anti-apoptotic protein Bcl-2 (P<0.001), and improved the neurological function score (P<0.001). Conclusion: Hyperbaric oxygen can exert a neuroprotective effect on a traumatic brain injury by activating the Akt signaling pathway. AD - S. Pan, Department of Hyperbaric Oxygen, Navy General Hospital, 6 Fucheng Road, Haidian District, Beijing, China AU - Meng, X. AU - Zhang, Y. AU - Li, N. AU - Fan, D. AU - Yang, C. AU - Li, H. AU - Guo, D. AU - Pan, S. DB - Embase KW - caspase 3 protein bcl 2 protein kinase B adult animal experiment animal model animal tissue apoptosis article controlled study hyperbaric oxygen therapy immunoblotting immunohistochemistry injury scale male nonhuman protein expression rat signal transduction traumatic brain injury TUNEL assay Western blotting LA - English M1 - 3 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1940-5901 SP - 6539-6544 ST - Effect of hyperbaric oxygen therapy on Akt signaling pathway in secondary injury associated with brain trauma T2 - International Journal of Clinical and Experimental Medicine TI - Effect of hyperbaric oxygen therapy on Akt signaling pathway in secondary injury associated with brain trauma UR - https://www.embase.com/search/results?subaction=viewrecord&id=L610014620&from=export VL - 9 ID - 931942 ER - TY - JOUR AB - BACKGROUND: The aim of this study was to investigate the efficacy of hyperbaric oxygen in secondary brain injury after trauma and its mechanism in a rat model. MATERIAL/METHODS: A rat model of TBI was constructed using the modified Feeney's free-fall method, and 60 SD rats were randomly divided into three groups--the sham group, the untreated traumatic brain injury (TBI) group, and the hyperbaric oxygen-treated TBI group. The neurological function of the rats was evaluated 12 and 24 hours after TBI modeling; the expression levels of TLR4, IκB, p65, and cleaved caspase-3 in the peri-trauma cortex were determined by Western blot; levels of TNF-α, IL-6, and IL-1β were determined by ELISA; and apoptosis of the neurons was evaluated by TUNEL assay 24 hours after TBI modeling. RESULTS: Hyperbaric oxygen therapy significantly inhibited the activation of the TLR4/NF-κB signaling pathway, reduced the expression of cleaved caspase-3, TNF-α, IL-6 and IL-1β (P<0.05), reduced apoptosis of the neurons and improved the neurological function of the rats (P<0.05). CONCLUSIONS: Hyperbaric oxygen therapy protects the neurons after traumatic injury, possibly through inhibition of the TLR4/NF-κB signaling pathway. AD - Department of Hyperbaric Oxygen, Navy General Hospital, Beijing, China (mainland). AN - 26812205 AU - Meng, X. E. AU - Zhang, Y. AU - Li, N. AU - Fan, D. F. AU - Yang, C. AU - Li, H. AU - Guo, D. Z. AU - Pan, S. Y. C2 - Pmc4734681 DA - Jan 26 DO - 10.12659/msm.894148 DP - NLM ET - 2016/01/27 J2 - Medical science monitor : international medical journal of experimental and clinical research KW - Animals Apoptosis/drug effects Brain Injuries/*metabolism/physiopathology/*therapy Caspase 3/metabolism Cytokines/metabolism *Hyperbaric Oxygenation I-kappa B Proteins/metabolism In Situ Nick-End Labeling Male NF-kappa B/*metabolism Neurons/drug effects/metabolism/pathology Oxygen/pharmacology Rats, Sprague-Dawley *Signal Transduction/drug effects Toll-Like Receptor 4/*metabolism Transcription Factor RelA/metabolism LA - eng N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1234-1010 (Print) 1234-1010 SP - 284-8 ST - Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-κB Signaling Pathway T2 - Med Sci Monit TI - Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-κB Signaling Pathway VL - 22 ID - 931858 ER - TY - JOUR AB - We investigated the effects of hyperbaric oxygen treatment on the Nrf2 signaling pathway in secondary injury following traumatic brain injury, using a rat model. An improved Feeney freefall method was used to establish the rat traumatic brain injury model. Sixty rats were randomly divided into three groups: a sham surgery group, a traumatic brain injury group, and a group receiving hyperbaric oxygen treatment after traumatic brain injury. Neurological function scores were assessed at 12 and 24 h after injury. The expression levels of Nrf2, heme oxygenase 1 (HO-1), and quinine oxidoreductase 1 (NQO-1) in the cortex surrounding the brain lesion were detected by western blotting 24 h after the injury. Additionally, the TUNEL method was used to detect apoptosis of nerve cells 24 h after traumatic injury and Nissl staining was used to detect the number of whole neurons. Hyperbaric oxygen treatment significantly increased the expression of nuclear Nrf2 protein (P < 0.05), HO-1, and NQO-1 in the brain tissues surrounding the lesion after a traumatic brain injury (P < 0.05) and also significantly reduced the number of apoptotic and injured nerve cells. The neurological function scores also improved with hyperbaric oxygen treatment (P < 0.05). Therefore, hyperbaric oxygen has a neuroprotective role in traumatic brain injury, which is mediated by up-regulation of the Nrf2 signaling pathway. AD - Department of Hyperbaric Oxygen, Navy General Hospital, Beijing, China. AN - 26909929 AU - Meng, X. E. AU - Zhang, Y. AU - Li, N. AU - Fan, D. F. AU - Yang, C. AU - Li, H. AU - Guo, D. Z. AU - Pan, S. Y. DA - Jan 29 DO - 10.4238/gmr.15016933 DP - NLM ET - 2016/02/26 J2 - Genetics and molecular research : GMR KW - Animals Apoptosis Brain Injuries, Traumatic/metabolism/*therapy Cerebral Cortex/*metabolism/physiopathology Disease Models, Animal GA-Binding Protein Transcription Factor/*genetics Heme Oxygenase (Decyclizing)/genetics *Hyperbaric Oxygenation Male NAD(P)H Dehydrogenase (Quinone)/genetics Neurons/metabolism/physiology Rats *Signal Transduction *Up-Regulation LA - eng M1 - 1 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1676-5680 ST - Effects of hyperbaric oxygen on the Nrf2 signaling pathway in secondary injury following traumatic brain injury T2 - Genet Mol Res TI - Effects of hyperbaric oxygen on the Nrf2 signaling pathway in secondary injury following traumatic brain injury VL - 15 ID - 931860 ER - TY - JOUR AB - Background: The aim of this study was to investigate the efficacy of hyperbaric oxygen in secondary brain injury after trauma and its mechanism in a rat model. Material/Methods: A rat model of TBI was constructed using the modified Feeney's free-fall method, and 60 SD rats were randomly divided into three groups - the sham group, the untreated traumatic brain injury (TBI) group, and the hyperbaric oxygen-treated TBI group. The neurological function of the rats was evaluated 12 and 24 hours after TBI modeling; the expression levels of TLR4, I kappa B, p65, and cleaved caspase-3 in the peri-trauma cortex were determined by Western blot; levels of TNF-alpha, IL-6, and IL-1 beta were determined by ELISA; and apoptosis of the neurons was evaluated by TUNEL assay 24 hours after TBI modeling. Results: Hyperbaric oxygen therapy significantly inhibited the activation of the TLR4/NF-kappa B signaling pathway, reduced the expression of cleaved caspase-3, TNF-alpha, IL-6 and IL-1 beta (P<0.05), reduced apoptosis of the neurons and improved the neurological function of the rats (P<0.05). Conclusions: Hyperbaric oxygen therapy protects the neurons after traumatic injury, possibly through inhibition of the TLR4/NF-kappa B signaling pathway. AD - [Meng, Xiang-En; Zhang, Yu; Li, Na; Fan, Dan-Feng; Yang, Chen; Li, Hang; Guo, Da-Zhi; Pan, Shu-Yi] Navy Gen Hosp, Dept Hyperbar Oxygen, Beijing, Peoples R China. Pan, SY (corresponding author), Navy Gen Hosp, Dept Hyperbar Oxygen, Beijing, Peoples R China. shuyipan_oooo@126.com AN - WOS:000368891200002 AU - Meng, X. E. AU - Zhang, Y. AU - Li, N. AU - Fan, D. F. AU - Yang, C. AU - Li, H. AU - Guo, D. Z. AU - Pan, S. Y. DA - Jan DO - 10.12659/msm.894148 J2 - Med. Sci. Monitor KW - Brain Injuries Hyperbaric Oxygenation Toll-Like Receptor 4 MICROGLIAL ACTIVATION INFLAMMATION TLR4 RAT Medicine, Research & Experimental LA - English M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2016 SN - 1643-3750 SP - 284-288 ST - Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-kappa B Signaling Pathway T2 - Medical Science Monitor TI - Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-kappa B Signaling Pathway UR - ://WOS:000368891200002 VL - 22 ID - 932018 ER - TY - JOUR AB - Background: Headache is the most common pain complaint following traumatic brain injury (TBI), and has been reported in up to 30-90% of patients. However, the time course and contributing factors for headache following severe head trauma are not well established. Most clinical studies report that headaches occur less frequently after severe TBI as compared to mild TBI. This inverse relationship is often attributed to under reporting of symptoms by patients with severe TBI due to associated higher rates of cognitive impairment. However, supporting evidence of this claim is limited. Here we describe subjects' report of headache three decades after severe TBI and examine potential association with cognitive status and psychological comorbidities. Methods: Thirty-two patients with severe TBI (Initial GCS ≤ 9) who were previously enrolled in a hyperbaric oxygen study at a Level One Trauma centre during the 1980s were recontacted. Participants completed a detailed health questionnaire and underwent the Telephone Interview for Cognitive Status-modified (TICS-m) to evaluate cognitive function. All analyses were done using a Pearson's Chi-Square test except when one cell dropped below a value of five then a Fisher's Exact test was used. Statistical significance was accepted at a p value < 0.05 and all tests were two-tailed. All analyses were completed with SAS version 9.4. Results: Follow-up duration was on average 29.66 years (median = 29.00) from date of injury. Headache was reported in 39% of patients and those with headache were significantly more likely to have comorbid depression (p = 0.02, 66% vs. 22%) and insomnia (p = 0.008, 92% vs. 42%). Self-reported anxiety was not associated with headache (p = 0.184) but was present in 33% of those with headaches vs. 11% of those without. Nearly 53% of the subjects had abnormal cognitive status (TICS-m score ≤ 32). There was no correlation between complaint of headache and level of cognition (p = 0.55). Level of cognition did not correlate with patient report of depression (p = 0.52), anxiety (p = 0.67) or insomnia (p = 0.65). Conclusion: Headache is a prominent pain complaint decades after severe TBI and may be more chronic and persistent than previously thought. Previous studies report that headaches occur less frequently after severe TBI, as opposed to mild TBI, and may be attributed to impaired cognition. However, our analysis demonstrates the level of cognition following severe TBI does not correlate with report of headache, depression, anxiety or insomnia. Headache was correlated with depression and insomnia, and may lead to the development of these comorbid conditions within this population. Further research is needed to examine mechanisms of pain processing and perception following severe TBI to help facilitate management and functional recovery. AD - G. Meyer, University of Minnesota, Department of Rehabilitation, Minneapolis, MN, United States AU - Meyer, G. AU - Hubbard, M. AU - Vonderhaar, K. AU - Rockswold, S. AU - Rockswold, G. AU - Tupper, D. AU - Gilberston, D. AU - Sexter, A. AU - Matlon, T. AU - Zahid, A. B. AU - Dammavalam, V. AU - Venkatesh, S. AU - Balser, D. AU - Galicich, W. AU - Bergman, T. AU - Samadani, U. DB - Embase DO - 10.1080/02699052.2017.1312145 KW - anxiety chi square test clinical article clinical trial cognitive defect comorbidity controlled clinical trial controlled study female follow up headache human hyperbaric oxygen therapy insomnia male multicenter study perception prevalence questionnaire statistical significance symptom telephone interview traumatic brain injury LA - English M1 - 6-7 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 1362-301X SP - 941 ST - Headache prevalence 30 years after severe traumatic brain injury T2 - Brain Injury TI - Headache prevalence 30 years after severe traumatic brain injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L617362032&from=export http://dx.doi.org/10.1080/02699052.2017.1312145 VL - 31 ID - 931920 ER - TY - JOUR AB - Heart rate variability (HRV) represents measurable output of coordinated structural and functional systems within the body and brain. Both mild traumatic brain injury (mTBI) and HRV are modulated by changes in autonomic nervous system function. We present baseline HRV results from an ongoing mTBI clinical trial. HRV was assessed via 24-hour ambulatory electrocardiography; recordings were segmented by physiological state (sleep, wakefulness, exercise, standing still). Time, frequency, and spatial domain measures were summarized and compared with symptoms, sleep quality, and neurological examination. Median low frequency/high frequency (LF/HF) ratio exceeded 1.0 across segments, indicating prevalence of sympathetic modulation. Abnormal Sharpened Romberg Test was associated with 29% LF/HF decrease (95% CI [2.1, 47.7], p=0.04); pathological nystagmus associated with decreased standard deviation of electrocardiogram R-R interval (SDNN) index (25% decrease, 95% CI [0.8, 43.4], p=0.04). Increased sympathetic modulation was associated with increased anger scores (19% LF/HF increase with 5-point State Trait Anger Expression Inventory-2 trait anger increase (95% CI [1.2, 39.1], p=0.04)). A 13% HF increase (95% CI [2.1, 25.7], p=0.02) was observed with increased Pittsburgh Sleep Quality Index scores. These results support autonomic nervous system dysfunction in service members after mTBI. AD - [Mirow, Susan] Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA. [Wilson, Steffanie H.; Lindblad, Anne S.] Emmes Corp, Rockville, MD USA. [Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] Intermt Med Ctr, Div Hyperbar Med, Murray, UT 84107 USA. [Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] Intermt LDS Hosp, Salt Lake City, UT 84143 USA. [Weaver, Lindell K.] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84132 USA. Weaver, LK (corresponding author), Intermt Med Ctr, Div Hyperbar Med, Murray, UT 84107 USA.; Weaver, LK (corresponding author), Intermt LDS Hosp, Salt Lake City, UT 84143 USA.; Weaver, LK (corresponding author), Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84132 USA. lindell.weaver@imail.org AN - WOS:000386867300005 AU - Mirow, S. AU - Wilson, S. H. AU - Weaver, L. K. AU - Churchill, S. AU - Deru, K. AU - Lindblad, A. S. J2 - Undersea Hyperb. Med. KW - mild traumatic brain injury heart rate variability autonomic nervous system post-concussive syndrome TRAUMATIC BRAIN-INJURY AUTONOMIC NERVOUS-SYSTEM POSTTRAUMATIC-STRESS-DISORDER HYPERBARIC-OXYGEN PANIC DISORDER POINCARE PLOT SLEEP DISTURBANCES DYSFUNCTION AGE Marine & Freshwater Biology Medicine, Research & Experimental LA - English M1 - 5 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2016 SN - 1066-2936 SP - 531-547 ST - Linear analysis of heart rate variability in post-concussive syndrome T2 - Undersea and Hyperbaric Medicine TI - Linear analysis of heart rate variability in post-concussive syndrome UR - ://WOS:000386867300005 VL - 43 ID - 932022 ER - TY - JOUR AB - Unestablished indications are conditions in which systematic clinical use of hyperbaric oxygen treatment (HBOT) is not supported by adequate proof of benefit. HBOT is vulnerable to use in many such conditions for various reasons, perhaps the most important being that a placebo or participation effect may create an impression of efficacy. The systematic use of HBOT in unestablished indications raises ethical concerns about provision of misleading information, giving false hope, and taking payment for therapy of doubtful benefit. Any practice perceived as unethical or unscientific has the potential to draw the wider field into disrepute. Of substantial contemporary relevance is the use of HBOT in treatment of various forms of chronic brain injury; in particular, cerebral palsy in children and the sequelae of mild traumatic brain injury in adults. There are now multiple, randomised, blinded, sham-controlled trials of HBOT in both indications. None of these studies showed benefit of HBOT when compared to sham control, though the sham and HBOT groups often both improved, indicating that a placebo or participation effect influenced outcomes. These results almost certainly explain those of open-label trials (lacking sham controls) in which HBOT frequently seems beneficial. Advocates for HBOT in chronic brain injury claim that the sham treatments (usually 1.3 ATA* pressure exposure whilst air breathing) in the blinded trials are actually active treatments; however, the same dose of oxygen can be achieved at 1 ATA breathing 27% oxygen. To counter this argument, advocates also claim that the extra 0.3 ATA of pressure is somehow independently beneficial, but this notion has limited biological plausibility and there is little supporting evidence. Chronic brain injuries remain unestablished indications at this time and, in our opinion, should not be systematically treated with HBOT. AD - S.J. Mitchell, Department of Anaesthesiology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand AU - Mitchell, S. J. AU - Bennett, M. H. DB - Embase Medline KW - alternative medicine article brain blood flow central nervous system cerebral palsy disorders of higher cerebral function functional magnetic resonance imaging general practitioner human hyperbaric oxygen therapy medical society neuropsychological test outcome assessment single photon emission computed tomography traumatic brain injury LA - English M1 - 4 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2014 SN - 1833-3516 SP - 228-234 ST - Unestablished indications for hyperbaric oxygen therapy T2 - Diving and Hyperbaric Medicine TI - Unestablished indications for hyperbaric oxygen therapy UR - https://www.embase.com/search/results?subaction=viewrecord&id=L610952353&from=export VL - 44 ID - 931949 ER - TY - JOUR AB - The National Brain Injury Rescue and Rehabilitation Project was established as a preliminary study to test the safety and practicality of multi-center hyperbaric oxygen administration for the post-concussive symptoms of chronic mild traumatic brain injury as a precursor to a pivotal, independent, multi-center, controlled clinical trial. This report presents the results for 32 subjects who completed a preliminary trial of hyperbaric oxygen several years before the passage of the 21 st Century Cures Act. This study anticipated the Act and its reassessment of clinical research. Subjects received 40-82 one-hour treatments at 1.5 atmospheres absolute 100% oxygen. Outcome measures included repeated self-assessment measures and automated neurocognitive tests. The subjects demonstrated improvement in 21 of 25 neurocognitive test measures observed. The objective neurocognitive test components showed improvement in 13 of 17 measures. Earlier administration of hyperbaric oxygen post injury, younger age at the time of injury and hyperbaric oxygen administration, military status, and increased number of hyperbaric oxygen administrations were characteristics associated with improved outcomes. There were no adverse events. Hyperbaric oxygen was found to be safe, inexpensive and worthy of clinical application in the 21 st Century model of facile data collection provided by recent research regulatory shifts in medicine. The study was approved by the ethics review committee of the Western Institutional Review Board (WIRB Protocol #20090761). Mozayeni B 1 Foundation for the Study of Inflammatory Disease, Bethesda, MD Duncan William 2 Patriot Clinics, Oklahoma City, OK Zant Eddie 3 Hyperbaric Medicine Inc. of Florida, Destin, FL Love Tommy 4 Concentra Medical Center, Salt Lake City, UT Beckman Robert 5 Foundation for the Study of Inflammatory Disease, Bethesda, MD Stoller Kenneth 6 Hyperbaric Oxygen Therapy San Francisco, American College of Hyperbaric Medicine, San Francisco, CA James Philip B. Oxygen and the Brain: The Journey of Our Lifetime. North Palm Beach, FL: Best Publishing Co., 2014. Weaver LK. Hyperbaric Oxygen Therapy: Indications, 13 th edition, Durham, NC: Undersea and Hyperbaric Medical Society, 2014. Carbon Monoxide poisoning, Neurological Decompression Sickness (Navy Dive Table 6A), Intercranial Abscess, Acute Hearing Loss, Radiation Necrosis of the Brain, compromised flaps and graphs, and arterial insufficiency. Jain, KK, The Textbook of Hyperbaric Medicine, Fifth edition. Cambridge, MA: Hogrefe & Huber Publishers, 2009, p.X. Golden ZL, Neubauer R, Golden CJ, Greene L, Marsh J, Mleko A. Improvement in cerebral metabolism in chronic brain injury after hyperbaric oxygen therapy. Int J Neurosci. 2002; 112:119- 131. Hardy P, Johnston KM, De Beaumont L, et al. Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury. J Neurol Sci. 2007;253:94-105. Neubauer RA, Gottlieb SF, Pevsner NH. Hyperbaric oxygen for treatment of closed head injury. South Med J 1994; 87:933- 936; Neubauer RA, Gottlieb SF. Hyperbaric oxygen for brain injury. J Neurosurg. 1993;78:687-688. Golden Z, Golden CJ, Neubauer RA. Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disabil Rehabil. 2006;28:1379-1386. Wright JK, Zant E, Groom K, Schlegel RE, Gilliland K. Case report: treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea Hyperb Med. 2009;36:391-399. H. R. 6, 114 th Congress, 1 st Session. To accelerate the discovery, development, and delivery of 21 st century cures, and for other purposes. The 21 st Century Cures Act. Signed into law December 13, 2016, Washington DC: Government Printing Office, 2016. Perrins DJ, James PB. Hyperbaric oxygen therapy and multiple sclerosis. Undersea Hyperb Med. 2002;29:236-238. Adamides AA, Winter CD, Lewis PM, Cooper DJ, Kossmann T, Rosenfeld JV. Current controversies in the management of patients with severe traumatic brain injury. ANZ J Surg. 2006; 76:163-174. Hyperbaric Oxygen Therapy: Don′t Be Misled. Washingto , DC: FDA Consumer Health Information, U.S. Food and Drug Administration, August 2013. Smith G, Sharp GR. Treatment of carbon-monoxide poisoning with oxygen under pressure. Lancet. 1960;2:905. Sluiter ME. The treatment of carbon monoxide poisoning by the administration of oxygen at high atmospheric pressure. Proc R Soc Med. 1963;56:1002-1008. Duff JH, Shibata HR, Vanschaik L, Usher R, Wigmore RA, MacLean LD. Hyperbaric oxygen: a review of treatment in eighty-three patients. Can Med Assoc J. 1967;97:510-515. Hart GB, Thompson RE. The treatment of cerebral ischemia with hyperbaric oxygen (OHP). Stroke. 1971;2:247-250. Neubauer RA, James P. Cerebral oxygenation and the recoverable brain. Neurol Res. 1998;20:S33-S36. Harch PG, Kriedt C, Van Meter KW, Sutherland RJ. Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury. Brain Res. 2007; 1174:120-129. Paris JJ, Schreiber MD, Reardon FE. Hyperbaric oxygen therapy for a neurologically devastated child: whose decision is it J Perinatol. 2003;23:250-253. Golden Z, Golden CJ, Neubauer RA. Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disabil Rehabil. 2006;28:1379-1386. Institute of Medicine of the National Academies, Treatment for Posttraumatic Stress Disorder in Military and Veteran Populations: Final Assessment, Washington, DC: Institute of Medicine, June 2014. Hoge CW, Jonas WB. The ritual of hyperbaric oxygen and lessons for the treatment of persistent postconcussion v symptoms in military personnel. JAMA Intern Med. 2014;175:53-54. Wolf G, Cifu D, Baugh L, Carne W, Profenna L. The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury. J Neurotrauma. 2012;29:2606-2612. Collet JP, Vanasse M, Marois P, et al. Hyperbaric oxygen for children with cerebral palsy: a randomised multicentre trial. Lancet. 2001;357:582-586. Harch PG. Hyperbaric oxygen therapy for post-concussion syndrome: contradictory conclusions from a study mischaracterized as sham-controlled. J Neurotrauma. 2013;30:1995-1999. Collet JP, Vanasse M, Marois P, et al. Hyperbaric oxygen for children with cerebral palsy: a randomised multicentre trial. Lancet. 2001;357:582-586. Harch PG. Letters to the Editor. Journal of Neurotrauma. Hyperbaric Oxygen Therapy for Post-Concussion Syndrome: Contradictory Conclusions From a Study Mischaracterized as Sham-Controlled. J Neurotrauma. 2013;30:1995-1999. Shively SB, Horkayne-Szakaly I, Jones RV, Kelly JP, Armstrong RC, Perl DP. Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series. Lancet Neurol. 2016;15:944-953. Rosenfeld JV, McFarlane AC, Bragge P, Armonda RA, Grimes JB, Ling GS. Blast-related traumatic brain injury. Lancet Neurol. 2013;12:882-893. Grammer GG, DeGraba TJ, Picon LM. va/dod clinical practice guideline for the management of concussion-mild traumatic brain injury, 2016 update. VA HSR&D Cyberseminars, September 29, 2016. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606-613. King NS, Crawford S, Wenden FJ, Moss NE, Wade DT. The Rivermead Post Concussion Symptoms Questionnaire: a measure of symptoms commonly experienced after head injury and its reliability. J Neurol. 1995;242:587-592. Vincent AS, Bleiberg J, Yan S, et al. Reference data from the Automated Neuropsychological Assessment Metrics for use in traumatic brain injury in an active duty military sample. Mil Med. 2008;173:836-852. Cernich A, Reeves D, Sun W, Bleiberg J. Automated Neuropsychological Assessment Metrics Sports Medicine Battery. Arch Clin Neuropsychol. 2007;22:S101-114. Segalowitz SJ, Mahaney P, Santesso DL, MacGregor L, Dywan J, Willer B. Retest reliability in adolescents of a computerized neuropsychological battery used to assess recovery from concussion. Neuro Rehabilitation. 2007;22:243-251. Johnson DR, Vincent AS, Johnson AE, Gilliland K, Schlegel RE. Reliability and construct validity of the Automated Neuropsychological Assessment Metri s (ANAM) mood scale. AD - R. Beckman, Foundation for the Study of Inflammatory Disease, Bethesda, MD, United States AU - Mozayeni, B. AU - Duncan, W. AU - Zant, E. AU - Love, T. AU - Beckman, R. AU - Stoller, K. DB - Embase Medline DO - 10.4103/2045-9912.254636 KW - adult age aged article clinical article clinical effectiveness disease association female human hyperbaric oxygen therapy injury severity male military service multicenter study observational study postconcussion syndrome priority journal therapy effect traumatic brain injury treatment outcome LA - English M1 - 1 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2019 SN - 2045-9912 SP - 1-12 ST - The National Brain Injury Rescue and Rehabilitation Study - A multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms T2 - Medical Gas Research TI - The National Brain Injury Rescue and Rehabilitation Study - A multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms UR - https://www.embase.com/search/results?subaction=viewrecord&id=L626984359&from=export http://dx.doi.org/10.4103/2045-9912.254636 VL - 9 ID - 931892 ER - TY - JOUR AB - The National Brain Injury Rescue and Rehabilitation Project was established as a preliminary study to test the safety and practicality of multi-center hyperbaric oxygen administration for the post-concussive symptoms of chronic mild traumatic brain injury as a precursor to a pivotal, independent, multi-center, controlled clinical trial. This report presents the results for 32 subjects who completed a preliminary trial of hyperbaric oxygen several years before the passage of the 21 (st) Century Cures Act. This study anticipated the Act and its reassessment of clinical research. Subjects received 40-82 one-hour treatments at 1.5 atmospheres absolute 100% oxygen. Outcome measures included repeated self-assessment measures and automated neurocognitive tests. The subjects demonstrated improvement in 21 of 25 neurocognitive test measures observed. The objective neurocognitive test components showed improvement in 13 of 17 measures. Earlier administration of hyperbaric oxygen post injury, younger age at the time of injury and hyperbaric oxygen administration, military status, and increased number of hyperbaric oxygen administrations were characteristics associated with improved outcomes. There were no adverse events. Hyperbaric oxygen was found to be safe, inexpensive and worthy of clinical application in the 21 (st) Century model of facile data collection provided by recent research regulatory shifts in medicine. The study was approved by the ethics review committee of the Western Institutional Review Board (WIRB; Protocol #20090761). AD - Foundation for the Study of Inflammatory Disease, Bethesda, MD, USA. Patriot Clinics, Oklahoma City, OK, USA. Hyperbaric Medicine Inc. of Florida, Destin, FL, USA. Concentra Medical Center, Salt Lake City, UT, USA. Hyperbaric Oxygen Therapy San Francisco, American College of Hyperbaric Medicine, San Francisco, CA, USA. AN - 30950414 AU - Mozayeni, B. R. AU - Duncan, W. AU - Zant, E. AU - Love, T. L. AU - Beckman, R. L. AU - Stoller, K. P. C2 - Pmc6463441 DA - Jan-Mar DO - 10.4103/2045-9912.254636 DP - NLM ET - 2019/04/06 J2 - Medical gas research KW - Adult Brain Injuries, Traumatic/complications/pathology/*therapy Female Humans *Hyperbaric Oxygenation Male Mental Status and Dementia Tests Military Personnel Outcome Assessment, Health Care Post-Concussion Syndrome/*complications Rehabilitation Research Severity of Illness Index Stress Disorders, Post-Traumatic/complications/diagnosis/therapy Young Adult *21st Century Cures Act *Hbot *Ptsd *concussion *hyperbaric oxygen *mTBI *post-concussion syndrome *post-traumatic stress disorder *traumatic brain injury case report form data collection software used to support this study provided pro bono to support the study. The other authors declare no conflict of interest. LA - eng M1 - 1 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 2045-9912 SP - 1-12 ST - The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms T2 - Med Gas Res TI - The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms VL - 9 ID - 931851 ER - TY - JOUR AB - Purpose: The purpose of this study is to examine the role of Hyperbaric Oxygen Therapy (HBOT) in decreasing symptoms in patients with a diagnosis of chronic post concussive syndrome (PCS). Hypothesis: The study hypothesis is that HBOT will decrease symptoms measured by standard measurement tools when provided to patients who have a diagnosis of PCS and are 6 months to 36 months post injury. Study Overview: Hyperbaric oxygen therapy (HBOT) involves the administration of inhaled 100% oxygen at increased ambient pressure inside a closed vessel. HBOT produces greatly elevated arterial and tissue oxygen tensions, producing a wide variety of physiological effects at the cellular and sub cellular level. Participants will be selected from the post‐concussive syndrome population based on an expectation that they would experience a clinically significant improvement. Eligible subjects will be experiencing post concussive symptoms related to an injury within the last 6 to 36 months. The study will be enrolling 150 paprticipants and will be randomized to two different treatment arms: experimental group and sham group. Participants will not be aware to which group they have been randomized. Each subject will receive a series of forty 2 hour treatments, delivered once a day, 5 days a week, within the hyperbaric oxygen chamber.There will be assessments completed before treatment series begins, at the end of treatment, 8 months and 14 months after treatment begins. The primary outcome will be administered at these times as well as every two weeks once treatment begins until the end of the study. AN - CN-01495378 AU - Nct KW - Post‐Concussion Syndrome Syndrome N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2017 ST - Hyperbaric Oxygen for Post Concussive Syndrome T2 - https://clinicaltrials.gov/show/NCT03205215 TI - Hyperbaric Oxygen for Post Concussive Syndrome UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01495378/full ID - 931956 ER - TY - JOUR AB - The study is designed as a prospective, randomized, controlled, cross‐over two groups trial. The study will be conducted in the ‐Sagol center for hyperbaric medicine and research and the children neurological unit of Assaf Harofeh Medical Center, Israel. Brain MRIs evaluation will be done the radiology department of Assaf‐Harofeh Medical Center, Israel. Study will include 70 patients After signing the informed consent (signed by the parents), patients will undergo computerized cognitive tests using the computerized Neurotrax and Moxo cognitive batteries. Patients who fulfill inclusion criteria will be included in the study. After signing informed consent (by parents, at the prescreening phase), patients who fill inclusion criteria, will be randomized in 1:1 manner into the treated or the control‐cross group. Randomization will be performed using a computer software according to patient id. After the randomization, patients will be invited for baseline evaluation that will include full review of their medical status and complete physical examination. All patients will go through evaluation of their neurocognitive function using further neurocognitive testing battery, questionnaires and brain imaging (perfusion MRI+DTI, SPECT). In cases of brain tumors, skull base tumors, encephalomalacia findings in MRI, patients will be excluded. The patients in the treated group will be evaluated three time ‐ at baseline, after 3 months of HBOT treatment and after another consequent 3 months period from treatment (6 months from baseline). The patients of the cross group will be evaluated three times as well‐ at baseline, after 3 month control period without hyperbaric treatment and after a consequent 3 month period of HBOT treatment. The following HBOT treatment protocol will be practiced: The patients will go through 60 HBOT treatments (each treatment session will be given on a separate day), distributed over three months (five days a week). Each session will be for 60 minutes in 100% oxygen atmosphere and at pressure of 1.5 ATA. AN - CN-01565703 AU - Nct KW - Brain Injuries Brain Injuries, Traumatic Post‐Concussion Syndrome Syndrome N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2017 ST - Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children T2 - https://clinicaltrials.gov/show/NCT03339037 TI - Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01565703/full ID - 931961 ER - TY - JOUR AB - The study will include 70 fibromyalgia patients in whom physical trauma, such mild traumatic brain injury (mTBI), could be considered as the trigger for FMS. Each participant will be examined at the time of recruitment and a diagnosis of FMS will be verified, based on the updated 2016 diagnostic criteria In the current study the investigators will recruit patients not currently being treated with medications specific for FMS, including anti‐depression drugs, gabapentanoids and tricyclics, opiods and medical cannabis. Patients who are on such treatment will be required to discontinue treatment 2 weeks before recruitment. Patients will undergo randomization upon recruitment to one of the two study groups. One group will proceed to a course of HBOT treatment while the second group will commence with standard treatment for FMS, as outlined in the Israeli guidelines for the diagnosis and treatment of FMS [41]. These patients will be given detailed education regarding the nature of FMS as well as recommendations regarding non ‐ pharmacological interventions recommended for FMS, including graded physical exercise, hydrotherapy, movement‐meditative treatments (e.g. Tai Chi) and cognitive behavioral treatment (CBT). HBOT protocol: a total of 60 daily hyperbaric oxygen treatment sessions will be administrated 5 days per week. 60 sessions will include exposure of 90 minutes to 100% at 2 Absolute atmospheres (ATA), with 5 minutes air breaks every 20 minutes. Pharmaceutical protocol: patients will be offered pharmacological treatment with one of the two medications currently licensed for the treatment of FMS in Israel, i.e. Cymbalta and Lyrica. Treatment with Lyrica will start at a dose of 75 mg at bedtime while treatment with Cymbalta will start at a dose of 30 mg a day (in the morning). After a period of 6 weeks patients will be evaluated and dose will be adjusted as necessary. Patients may also be switched from one medication to the other based according to clinical judgment. Crossover: After 3 months of either pharmaceuitical or HBOT, once the 2nd evaluation is completed, all patients in both groups will be offered to switch to the alternative treatment group. AN - CN-01565278 AU - Nct KW - Duloxetine Hydrochloride Fibromyalgia Myofascial Pain Syndromes Pregabalin N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2017 ST - Hyperbaric Oxygen Compared to Pharmaceutical Therapies for Fibromyalgia Syndrome T2 - https://clinicaltrials.gov/show/NCT03325959 TI - Hyperbaric Oxygen Compared to Pharmaceutical Therapies for Fibromyalgia Syndrome UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01565278/full ID - 931979 ER - TY - JOUR AB - Background and Rationale: Cerebrovascular disease is always ranked at the top causes of death and most of hospitalized acute stroke patients have ischemic stroke [1]. Although the mortality rate of acute ischemic stroke is less than that of hemorrhagic stroke [1], it still results in patient disabilities and complications that often lead to significant costs to individuals, families, and society. Traditional treatment for acute ischemic stroke includes thrombolytic therapy by injecting tissue plasminogen activator (t‐PA) within three hours after onset of symptoms [2], antiplatelets and/or anticoagulant agents administered within the first 48 hours. Clinically, the narrow time window of thrombolytic therapy and coexisting contraindications limit the use of t‐PA [2]. Thus, searching for an effective supplemental treatment for acute ischemic stroke is imperative. Hyperbaric oxygen therapy (HBOT) is valuable in treating acute carbon monoxide poisoning [3,4], air or gas embolism [5], facilitating wound healing [6] and has been used as an adjuvant treatment for many neurological disorders that need further study as concussion [7] , stroke [8,9], cerebral palsy [ 10],traumatic brain injury [ 11], cerebral air embolism [12], Autism [13] and multiple sclerosis [14]. Indications of hyperbaric oxygen therapy recommended by undersea and hyperbaric medical society (UHMS) [15] are 1.air or gas embolism [5], 2.carbon monoxide poisoning [3,4], 3.clostridial myositis and myonecrosis [16], 4.crush injury, compartment syndrome and other acute traumatic ischemias [17], 5.decompression sickness [18], 6.arterial insufficiencies [19], 7.severe anemia [20], 8.intracranial abscess [21], 9.necrotizing soft tissue infections [22],10. refractory osteomyelitis [23], 11.delayed radiation injury [24], 12.compromised grafts and flaps [25], 13.acute thermal burn injury [26] and 14.idiopathic sudden sensorineural hearing loss [27]. Known mechanisms of HBOT‐induced neuroprotection include enhancing neuronal viability via increased tissue oxygen delivery to the area of diminished blood flow, reducing brain edema, and improving metabolism after ischemia [28,29]. Furthermore, a recent study performed on a rat suggested that upregulation of the expression of glial derived neurotrophic factor (GDNF) and nerve growth factor (NGF) might underlie the effect of HBOT [30]. The effectiveness of use of Hyperbaric oxygen therapy in human ischemic stroke is still controversial that need further evaluation. AN - CN-01593690 AU - Nct KW - Stroke N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2018 ST - Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke T2 - https://clinicaltrials.gov/show/NCT03431402 TI - Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01593690/full ID - 931958 ER - TY - JOUR AB - Research Methodology A prospective cohort study will be conducted. The follow‐up periods are 18 weeks. Diagnostic criteria of mild and moderate traumatic brain injury. Diagnostic criteria of traumatic brain injury will be according to (1) American Association of Neurosurgical Surgeons (AANS) Guidelines for The Management of Severe Head Injury; (2) YOUMANS Neurological Surgery Fifth Edition Guidelines for Traumatic Brain Injury. Definitions and classifications Traumatic brain injury is defined as damage to the brain resulting from external mechanical force, such as rapid acceleration or deceleration, impact, blast waves, or penetration by a projectile. Consequently to the injury, brain function is temporarily or permanently impaired and structural damage may or may not be detectable with current imaging technology. TBI is usually classified based on severity, anatomical features of the injury, and the cause of the injury. The severity is assessed according to the loss of consciousness (LOC) duration, the post‐traumatic amnesia (PTA), and the Glasgow coma scale (GCS) grading of the level of consciousness. Approximately (70‐90%) of the TBI in the US are classified as mild TBI (mTBI) or concussion ‐ LOC duration of 0‐30 minutes, PTA duration of less than a day and GCS grade of 13‐15. Post concussion syndrome (PCS) is a set of symptoms succeeding mTBI in most patients. The PCS symptoms include headache, dizziness, neuropsychiatric symptoms, and cognitive impairments. In most patients, PCS may continue for weeks or months, and up to 25% of the patients may experience prolonged PCS (PPCS) in which the symptoms last for over six months. Such individuals are at high risk for emotional and cognitive dysfunction, culminating in inability to carry out ordinary daily activities, work responsibilities and standard social relationships. Hypotheses and Purpose: In this study, the investigators hypothesize that the hyperbaric oxygen therapy in neurotherapeutics, in light of recent persuasive evidence for hyperbaric oxygen therapy efficacy in brain repair and of new understanding of brain energy management and response to damage. The investigators discuss the optimal timing of treatment, optimal dose‐response curve (oxygenpressure levels), suitable candidates and promising future directions. The investigators speculate that these changes of biomarkers correlated with the hyperbaric oxygen therapy efficacy and the progression of neuropsychological testing during the 18 weeks follow‐up. The investigators plan to conduct this research project through hyperbaric oxygen therapy and neuropsychological therapy and using scientific tests and neurocognitive function assessments. The scientific tests including flow cytometry to evaluate the fraction of circulating activated platelets, the proportion of leukocytosis apoptosis, Erythrocyte assay of antioxidant enzymes and Enzyme‐Linked Immunosorbent Assay (ELISA) for inflammatory markers. Purpose: 1. To evaluate that whether the treatment of hyperbaric oxygen can improve oxidative stress and inflammatory response after brain injury, and observe changes in biomarker concentration. 2. To evaluate that whether hyperbaric oxygen therapy and neuropsychological therapy can improve cognitive function after brain injury. 3. To evaluate that which biomarkers are factors that influence the prognosis of cognitive function. AN - CN-01965427 AU - Nct KW - Brain Injuries Brain Injuries, Traumatic Wounds and Injuries N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2019 ST - The Role of Hyperbaric Oxygen and Neuropsychological Therapy in Cognitive Function Following Traumatic Brain Injury T2 - https://clinicaltrials.gov/show/NCT03900182 TI - The Role of Hyperbaric Oxygen and Neuropsychological Therapy in Cognitive Function Following Traumatic Brain Injury UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01965427/full ID - 931955 ER - TY - JOUR AB - Post‐traumatic stress disorder (PTSD) is the brain's long‐term imprint of a traumatic event. PTSD is characterized by intrusive thoughts, nightmares and flashbacks of past traumatic events, avoidance of trauma reminders, hypervigilance, and sleep disturbance, all of which lead to considerable social, occupational, and interpersonal dysfunction. The current available treatments for PTSD include medications and psychotherapy. However, a substantial proportion of patients have treatment resistant PTSD. In recent years there is growing evidence that traumatic events can induce changes in the brain's structure and function that may persist months or even years after the acute event. The "non‐healing brain wound" can be visualized using functional imaging. The new insight regarding the biological nature of PTSD obligates biological intervention that can induce neuroplasticity and recovery of the damage brain tissue. Hyperbaric Oxygen Therapy (HBOT) includes the inhalation of 100% oxygen in a pressurized chamber with pressures exceeding 1 atmosphere absolute (ATA), thus enhancing the amount of oxygen dissolved in the body's tissues. It is now understood that the combined action of both hyperoxia and hyperbaric pressure together with, oxygen fluctuations generated by a pre‐defined protocol may target both oxygen and pressure sensitive genes, resulting in improved mitochondrial metabolism with anti‐apoptotic and anti‐inflammatory effects. Moreover, these genes induce the proliferation of stem cells, augmented circulating levels of endothelial progenitor cells (EPCs) and angiogenesis factors, which induce angiogenesis and improved blood flow in the ischemic area. In recent years there is growing evidence that HBOT induced brain neuroplasticity leads to repair of chronically impaired brain functions in post‐stroke and in traumatic brain injury (TBI) patients with prolonged post‐concussion syndrome, even years after the brain insult, as well as in healthy aging adults. HBOT can also induce neuroplasticity and significantly improve the clinical symptoms of the most common prototype of central sensitization syndrome ‐ fibromyalgia syndrome. The effects of HBOT on patients suffering from chronic unremitting PTSD due to combat trauma were evaluated in a pilot study done in the investigator's institute. The recently done study included veterans with combat associated PTSD according to the Ministry of Defense (MOD) criteria, who failed to improve using the current available treatments. The results of the study demonstrated the beneficial effect of HBOT in this unfortunate severely injured unremitting PTSD population. Clinically significant improvement was demonstrated in a major fraction of study participants. In correlation with the clinical improvement, a significant improvement in brain activity was demonstrated in the functional MRI imaging. The aim of the current study is to evaluate the effect of HBOT on chronic unremitting combat associated PTSD in an double blind sham control study AN - CN-02162913 AU - Nct KW - Stress Disorders, Post‐Traumatic Stress Disorders, Traumatic N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2020 ST - Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder T2 - https://clinicaltrials.gov/show/NCT04518007 TI - Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-02162913/full ID - 931957 ER - TY - JOUR AB - Background: Although survival rates of critically ill patients in Intensive Care Units (ICUs) have improved in recent years, many risk factors cause a few serious complications. This study aimed to evaluate efficacy and safety of comprehensive early rehabilitation therapy for ICU patients. Material/Methods: This study recruited ICU patients who were diagnosed as having cerebral hemorrhage or traumatic brain injury. ICU patients were randomly divided into an early rehabilitation therapy group (Observation group, n=21) and a Control group (n=21). Patients in the Control group underwent persistent monitoring of respiratory functions and blood oxygen saturation, as well as electrocardiographic monitoring. ICU patients in the Observation group underwent individualized treatments based on conventional treatments. APACHE II scores, MRC scores, and consciousness improvement rates of ICU patients were evaluated. Incidences of adverse events and complications were also assessed. Results: Early rehabilitation therapy significantly decreased APACHE II scores and significantly increased MRC scores compared to the Control group (p<0.05). Early rehabilitation therapy significantly improved consciousness of ICU patients compared to the Control group (p<0.05). Early rehabilitation therapy significantly reduced the incidence of complications compared to the Control group (p<0.05). Early rehabilitation therapy significantly shortened ICU or total hospital stay and mechanical ventilation time compared to the Control group (p<0.05). Conclusions: Early rehabilitation therapy decreased APACHE II scores, enhanced MRC scores, and improved consciousness of ICU patients. Moreover, early rehabilitation therapy also reduced the incidence of complications and shortened ICU or total hospital stay and mechanical ventilation time of ICU patients. Therefore, early rehabilitation therapy was shown to be effective and safe for ICU patients. AD - H. Li, Second Department of Rehabilitation, Second Hospital, Hebei Medical University, Shijiazhuang, Hebei, China AU - Pang, Y. AU - Li, H. AU - Zhao, L. AU - Zhang, C. DB - Embase Medline DO - 10.12659/MSM.916210 KW - intravascular catheter adult anti-infective therapy APACHE article artificial ventilation blood oxygen tension brain hemorrhage clinical effectiveness comprehensive sensory stimulation therapy consciousness controlled study deep vein thrombosis disease classification Doppler flowmetry electrocardiography female fluid balance Glasgow coma scale heart arrest heart arrhythmia hemodynamics hospitalization human hyperbaric oxygen therapy incidence intensive care unit intracranial pressure male mechanical ventilation time Medical Research Council score middle aged muscle strength observational study oxygen saturation physical activity pneumonia rehabilitation care respiratory function scoring system tracheotomy training traumatic brain injury ventilation time LA - English M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2019 SN - 1643-3750 1234-1010 SP - 7052-7058 ST - An established early rehabilitation therapy demonstrating higher efficacy and safety for care of intensive care unit patients T2 - Medical Science Monitor TI - An established early rehabilitation therapy demonstrating higher efficacy and safety for care of intensive care unit patients UR - https://www.embase.com/search/results?subaction=viewrecord&id=L2003333434&from=export http://dx.doi.org/10.12659/MSM.916210 VL - 25 ID - 931888 ER - TY - GEN AN - NCT00760734 AU - Paul G. Harch, M.D. AU - Fund, Semper Fi AU - Foundation, Marine Corps-Law Enforcement AU - Heroes, Coalition to Support America's AU - contributors, Thirty-eight other AU - Orleans, Louisiana State University Health Sciences Center in New DA - September KW - TBI (Traumatic Brain Injury)|Post Concussion Syndrome|Post Traumatic Stress Disorder|Chronic Post Traumatic Stress Disorder N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT00760734 PY - 2008 ST - Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD) TI - Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD) ID - 932046 ER - TY - JOUR AB - Objectives: Complex Neuropsychiatric conditions with multiple comorbidities can benefit from novel treatments, in addition to medication. Among these are 1) concurrent application of Transcranial Magnetic Stimulation and ketamine infusion (combination TMS/ketamine). 2) Hyperbaric Oxygen Therapy (HBOT). 3) Perispinal administration of etanercept (PSE). In our clinic, complex patients undergo a baseline Brain SPECT and occasionally follow-up studies after periods of treatment. We are presenting the findings for patients who underwent such repeat studies. Methods: 6 patients presented with disabling Neuropsychiatric conditions of various causes after having been treated unsuccessfully for long periods of time elsewhere. Brain SPECT: on triple head camera, HMPAO, and special software combining a set of multiparametric displays. A discrete color scale was used for orthogonal + temporal lobe sections as well as for a set of normalized surface displays, and a monochrome display of thresholded volumes. The clarity and complementarity of the displays enabled rEliable visual evaluation. The comorbidities differed in each case. (I) 62 y.o.f.: on verge of suicide with Treatment Resistant Depression, grief and effects of prolonged polypharmacy. (II) 34 y.o.f.: regulatory disorder of childhood, 2 concussions, post-traumatic epilepsy, and RSD, resulting in major incapacitation. (III) 54y.o.m: childhood Tourette's, long hx of alcohol abuse, severe depression, fatigue, sleep apnea. (IV) 55y.o.f: major depression, panic/agoraphobia, long term back pain, frequent headaches. (V) 43y.o.m: bipolar II, anxiety, impulsive behavior, family stressors, inability to hold job. (VI) 77y.o.m: 3 years post dementia induced by General Anesthesia with major cognitive, physical and emotional impairments. Results: Baseline SPECT showed multiple extensive perfusion abnormalities in all 6 cases. Post treatment results are as follows: Patient (I). Following 5 months of combination TMS/ketamine, SPECT showed a marked improvement, across the board, in cortical and subcortical structures. Patient (II). After HBOT: multiple areas of improved perfusion. Subsequent follow-up done after 4 PSE injections showed major improvements in all lobes and subcortical areas. Patient (III). Following combination TMS/ketamine treatment, SPECT done 5 months later showed several improvements including in the area of severe frontal underperfusion. After] ongoing medication and the addition of CPAP, life style changed and 14 mo later SPECT showed additional significant improvements. Patient (IV). Following combination TMS/ketamine, SPECT 14mo later shows major bilateral improvement in all affected areas. Patient(V). Post combination TMS/ketamine, at 5 1/2 mo SPECT showed improvement in practically all previously under-perfused areas. Patient(VI): Following a combination HBOT and PSE injections, SPECT at 5 mo showed localized areas of improvement in key locations including right mesial temporal, cingulate gyrus and parts of the lateral frontal lobes. Improvements in all patients were documented via periodic clinical evaluations, Neuropsycholgic testing (in some cases) and family members observations. Baseline brain SPECT contributed to decision and tailoring of treatment. Followup SPECT not only validated the beneficial treatment effect but also had a significant role in guiding long term treatment strategy by showing the topographic functional status. Conclusion: The use of brain SPECT, in this context, provides a useful biomarker for confirmation/explanation of the therapeutic benefit of the novel types of treatments used, as well as for deciding upon future therapeutic needs or, lack of thereof. AD - D. Pavel, Neuroscience Center, PathFinder Brain SPECT Imaging, Deerfield, IL, United States AU - Pavel, D. AU - Best, S. DB - Embase KW - biological marker etanercept ketamine agoraphobia alcohol abuse anxiety backache bipolar II disorder child childhood disease cingulate gyrus clinical article clinical evaluation comorbidity concussion congenital malformation dementia drug combination family study fatigue female follow up frontal lobe functional status general anesthesia grief headache human hyperbaric oxygen therapy imaging impulsiveness injection lifestyle male panic perfusion polypharmacy positive end expiratory pressure ventilation psychiatry single photon emission computed tomography sleep disordered breathing software suicide temporal lobe traumatic epilepsy treatment resistant depression LA - English M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 2159-662X ST - Brain SPECT as imaging biomarker for evaluating effects of novel treatments in psychiatry T2 - Journal of Nuclear Medicine TI - Brain SPECT as imaging biomarker for evaluating effects of novel treatments in psychiatry UR - https://www.embase.com/search/results?subaction=viewrecord&id=L617552385&from=export VL - 58 ID - 931915 ER - TY - JOUR AB - BACKGROUND: The concept of delivering high amounts of oxygen at a greater atmospheric pressure has been proven to increase the amount of oxygenated blood in the body ("What is Hyperbaric Oxygenation? How Does it Work?," 2018). The usefulness of hyperbaric oxygen therapy (HBOT) for the treatment of traumatic brain injury (TBI) has been wildly debated and sometimes controversial. As TBI's increase in prevalence, it is important to recognize potentially positive and useful treatments. OBJECTIVES: To evaluate the effectiveness of HBOT in the treatment of symptomatic and behavioral concerns caused by TBI. METHODS: Inclusion criteria were based on the study being a random-ized control trial (RCT), a confirmed diagnosis of post-concussion syn-drome or TBI and HBOT must be used as the primary treatment intervention. The two limits placed on the search were reports of English origin and human studies. RESULTS: A primary electronic search was completed using three databases producing 122 articles. Once duplicates were removed and full-text articles were reviewed, eight RCT's remaining for analysis. A total of five outcomes were evaluated: intracranial pressures, cognitive scores, quality of life, Glasgow Coma and Outcome Scores (GCS/GOS) and motor skills and coordination. DISCUSSION: HBOT showed improvements in GOS scores in three articles while one article stated that HBOT was not suggested in the treatment of fine motor speed and balance. Most articles believed the use of HBOT had favorable results in the treatment of traumatic brain injury. HBOT enhances the body's natural healing process by increasing diffusion distance of oxygen into the impaired tissue and promotes neu-rovascular regeneration. CONCLUSION: HBOT has shown to have positive results in the treatment of traumatic brain injuries however more research needs to be done to include greater subgroup analysis and more diversity in participant selection. AD - B. Pedreira, University of Manitoba, Winnipeg, MB, Canada AU - Pedreira, B. DB - Embase KW - endogenous compound epidermal growth factor receptor 2 oxygen adult clinical assessment coma comparative effectiveness conference abstract coordination diagnosis diffusion human hyperbaric oxygen therapy intracranial pressure motor performance postconcussion syndrome quality of life regeneration tissue oxygenation traumatic brain injury velocity LA - English M1 - 2 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2018 SN - 2368-6820 SP - 55 ST - Is hyperbaric oxygen therapy an effective treatment for post-concussion syndrome and traumatic brain injury? T2 - Canadian Journal of Respiratory Therapy TI - Is hyperbaric oxygen therapy an effective treatment for post-concussion syndrome and traumatic brain injury? UR - https://www.embase.com/search/results?subaction=viewrecord&id=L624570272&from=export VL - 54 ID - 931908 ER - TY - JOUR AB - BACKGROUND: The concept of delivering high amounts of oxygen at a greater atmospheric pressure has been proven to increase the amount of oxygenated blood in the body ("What is Hyperbaric Oxygenation? How Does it Work?," 2018). The usefulness of hyperbaric oxygen therapy (HBOT) for the treatment of traumatic brain injury (TBI) has been wildly debated and sometimes controversial. As TBI's increase in prevalence, it is important to recognize potentially positive and useful treatments. OBJECTIVES: To evaluate the effectiveness of HBOT in the treatment of symptomatic and behavioral concerns caused by TBI. METHODS: Inclusion criteria were based on the study being a randomized control trial (RCT), a confirmed diagnosis of post-concussion syndrome or TBI and HBOT must be used as the primary treatment intervention. The two limits placed on the search were reports of English origin and human studies. RESULTS: A primary electronic search was completed using three databases producing 122 articles. Once duplicates were removed and full-text articles were reviewed, eight RCT's remaining for analysis. A total of five outcomes were evaluated: intracranial pressures, cognitive scores, quality of life, Glasgow Coma and Outcome Scores (GCS/GOS) and motor skills and coordination. DISCUSSION: HBOT showed improvements in GOS scores in three articles while one article stated that HBOT was not suggested in the treatment of fine motor speed and balance. Most articles believed the use of HBOT had favorable results in the treatment of traumatic brain injury. HBOT enhances the body's natural healing process by increasing diffusion distance of oxygen into the impaired tissue and promotes neu-rovascular regeneration. CONCLUSION: HBOT has shown to have positive results in the treatment of traumatic brain injuries however more research needs to be done to include greater subgroup analysis and more diversity in participant selection. AD - University of Manitoba, Winnipeg, MB, Canada AN - 130767024. Language: English. Entry Date: 20180720. Revision Date: 20190628. Publication Type: Article AU - Pedreira, B. DA - Summer2018 DB - CINAHL DP - EBSCOhost KW - Hyperbaric Oxygenation Treatment Outcomes Postconcussion Syndrome -- Therapy Brain Injuries -- Therapy Congresses and Conferences -- British Columbia British Columbia M1 - 2 N1 - CINAHL (EbscoHost) Literature search date last searched June 18, 2021 PY - 2018 SN - 1205-9838 SP - 55-55 ST - IS HYPERBARIC OXYGEN THERAPY AN EFFECTIVE TREATMENT FOR POST-CONCUSSION SYNDROME AND TRAUMATIC BRAIN INJURY?...Canadian Society of Respiratory Therapists Annual Education Conference May 24-26, 2018 Vancouver, British Columbia T2 - Canadian Journal of Respiratory Therapy TI - IS HYPERBARIC OXYGEN THERAPY AN EFFECTIVE TREATMENT FOR POST-CONCUSSION SYNDROME AND TRAUMATIC BRAIN INJURY?...Canadian Society of Respiratory Therapists Annual Education Conference May 24-26, 2018 Vancouver, British Columbia UR - http://libproxy.temple.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=130767024&site=ehost-live&scope=site VL - 54 ID - 932029 ER - TY - JOUR AB - Although deforming contractures of the lower extremities after acute cerebrovascular events are well documented in the literature, there is limited literature regarding specific surgical considerations for the correction of these deformities, which are nonosseus in nature. The equinovarus foot, regardless of its origin, is a challenging pathologic condition for the foot and ankle surgeon. It is critical to have a firm understanding of the cause and symptoms behind an equinovarus deformity before treatment. The clinical presentation is discussed with special attention to deformities in adults with rigid equinovarus deformities after cerebrovascular-related accidents or peripheral ischemic events. AD - C.L. Reeves, Orlando Foot and Ankle Clinic, 2111 Glenwood Drive, Suite 104, Winter Park, FL, United States AU - Reeves, C. L. AU - Shane, A. M. AU - Zappasodi, F. AU - Payne, T. DB - Embase Medline DO - 10.1016/j.cpm.2015.06.009 KW - haloperidol adult aged biomechanics case report cerebrovascular accident clinical examination clinical feature compression therapy daily life activity debridement decompression surgery decubitus dystonia fasciotomy female flexor digitorum longus tendon flexor hallucis longus tendon follow up foot edema foot orthosis human hyperbaric oxygen therapy male middle aged mobilization muscle tone muscle weakness Parkinson disease peroneus brevis tendon peroneus longus tendon clubfoot physical examination pie crusting technique postoperative period priority journal review skin transplantation soft tissue release split thickness skin graft surgical approach surgical technique tarsal tunnel syndrome tendon tendon contracture tendon sheath tendon surgery tenotomy thrombectomy tibialis anterior muscle tibialis posterior tendon traumatic brain injury very elderly wound care wound dehiscence LA - English M1 - 1 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1558-2302 0891-8422 SP - 139-152 ST - Surgical Correction of Rigid Equinovarus Contracture Utilizing Extensive Soft Tissue Release T2 - Clinics in Podiatric Medicine and Surgery TI - Surgical Correction of Rigid Equinovarus Contracture Utilizing Extensive Soft Tissue Release UR - https://www.embase.com/search/results?subaction=viewrecord&id=L605866614&from=export http://dx.doi.org/10.1016/j.cpm.2015.06.009 VL - 33 ID - 931945 ER - TY - GEN AN - NCT01306968 AU - Research, U.S. Army Medical AU - Command, Development DA - February KW - Post-concussive Symptoms|Traumatic Brain Injury N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT01306968 PY - 2011 ST - hopps TI - Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) ID - 932044 ER - TY - GEN AN - NCT01611194 AU - Research, U.S. Army Medical AU - Command, Development DA - September 11 KW - Traumatic Brain Injury With Brief Loss of Consciousness|Post-Concussion Syndrome N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT01611194 PY - 2012 ST - bima TI - mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms ID - 932054 ER - TY - JOUR AB - Background: The U.S. military has seen dramatic increases in traumatic brain injuries (TBIs) among military personnel due to the nature of modern-day conflicts. Conventional TBI treatment for secondary brain injuries has suboptimal success rates, and patients, families, and healthcare professionals are increasingly turning to alternative medicine treatments. Objective: Effective treatments for the secondary injury cascades that occur after an initial brain trauma are unclear at this time. The goal of successful treatment options for secondary TBI injuries is to reduce oxidative stress, excitotoxicity, and inflammation while supporting mitochondrial functions and repair of membranes, synapses, and axons. Intervention: A new paradigm of medical care, known as functional medicine, is increasing in popularity and acceptance. Functional medicine combines conventional treatment methods with complementary, genetic, holistic, and nutritional therapies. The approach is to assess the patient as a whole person, taking into account the interconnectedness of the body and its unique reaction to disease, injury, and illness while working to restore balance and optimal health. Functional medicine treatment recommendations often include the use of acupuncture, Ayurveda, chiropractic manipulation, detoxification programs, herbal and homeopathic supplements, specialized diets, massage, meditation and mindfulness practices, neurobiofeedback, nutritional supplements, t'ai chi, and yoga. At present, some of these alternative treatments appear to be beneficial, but more research is needed to validate reported outcomes. Conclusions: Few clinical studies validate the effectiveness of alternative therapies for TBIs. However, further clinical trials and empirical studies warrant further investigation based on some reported positive results from research studies, case histories, anecdotal evidence, and widespread popularity of some approaches. To date, only nutritional therapies and hyperbaric oxygen therapy have shown the most promise and potential for improved outcomes for the treatment of secondary TBI injuries. AD - Spaulding Rehab Outpatient Centers, Charlestown, MA. AN - 28874921 AU - Richer, A. C. C2 - Pmc5580364 DA - Aug 1 DO - 10.1089/acu.2017.1217 DP - NLM ET - 2017/09/07 J2 - Medical acupuncture KW - alternative medicine dietary supplements functional medicine hyperbaric oxygen therapy omega-3 fatty acids traumatic brain injury LA - eng M1 - 4 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2017 SN - 1933-6586 (Print) 1933-6586 SP - 206-214 ST - Functional Medicine Approach to Traumatic Brain Injury T2 - Med Acupunct TI - Functional Medicine Approach to Traumatic Brain Injury VL - 29 ID - 931852 ER - TY - JOUR AB - We report on hyperbaric oxygen (HBO2) therapy used to improve postinjury outcomes in eight acutely concussed high school student-athletes (5 males, 3 females, mean age = 16.0 ± 1.2 years). Patients were randomly assigned into one of three intervention groups: (a) HBO2 therapy; (b) hyperbaric therapy with compressed medical-grade air (HBA); or (c) normobaric 100% O2 therapy. All patients completed five 1-hr treatments within the first 10 days following his or her concussion. Main outcome measures included mental status examination, symptom burden, and the number of days from injury until the physician permitted the student-athlete to return to activity. Patients receiving HBO2 treatment experienced the greatest absolute symptom reduction over the five treatment sessions. No meaningful differences were found in mental status examination. All participants returned to activity in a similar timeframe. HBO2 therapy may be an effective option for the acute treatment of postconcussion symptoms, particularly in young athletes presenting with a high symptom burden. AD - The University of North Carolina at Chapel Hill University of Georgia Carolina Family Practice & Sports Medicine AN - 150085409. Language: English. Entry Date: 20210506. Revision Date: 20210513. Publication Type: Article AU - Roby, Patricia R. AU - Lynall, Robert C. AU - Cools, Michael J. AU - Marshall, Stephen W. AU - Fonseca, Janna C. AU - Stevens, James R. AU - Mihalik, Jason P. DB - CINAHL DO - 10.1123/ijatt.2019-0135 DP - EBSCOhost KW - Hyperbaric Oxygenation Brain Injuries -- Therapy Athletic Injuries -- Therapy Students, High School Athletes Male Female Random Assignment Randomized Controlled Trials Scales Descriptive Statistics Treatment Outcomes Adolescence Human Funding Source M1 - 3 N1 - CINAHL (EbscoHost) Literature search date last searched June 18, 2021 PY - 2021 SN - 2157-7277 SP - 140-144 ST - Hyperbaric Oxygen Therapy to Treat Acute Sport-Related Traumatic Brain Injuries: A Case Series T2 - International Journal of Athletic Therapy & Training TI - Hyperbaric Oxygen Therapy to Treat Acute Sport-Related Traumatic Brain Injuries: A Case Series UR - http://libproxy.temple.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=150085409&site=ehost-live&scope=site VL - 26 ID - 932028 ER - TY - JOUR AU - Sawyer, Quinton AU - Phoenix Suns, A. Z. AU - Department of Interdisciplinary Health Sciences, Arizona School of Health Sciences A. T. Still University Mesa AU - Vesci, Brian AU - Northwestern University, Evanston I. L. AU - Department of Interdisciplinary Health Sciences, Arizona School of Health Sciences A. T. Still University Mesa AU - McLeod, Tamara C. Valovich AU - Department of Interdisciplinary Health Sciences, Arizona School of Health Sciences A. T. Still University Mesa DO - 10.4085/1062-6050-51.12.01 M1 - 9 PY - 2021 SN - 1062-6050 SP - 739-742 ST - Physical Activity and Intermittent Postconcussion Symptoms After a Period of Symptom-Limited Physical and Cognitive Rest T2 - Journal of Athletic Training TI - Physical Activity and Intermittent Postconcussion Symptoms After a Period of Symptom-Limited Physical and Cognitive Rest UR - https://meridian.allenpress.com/jat/article-pdf/51/9/739/1457881/1062-6050-51_12_01.pdf VL - 51 ID - 932055 ER - TY - JOUR AB - Neuroplasticity and recovery after stroke can be enhanced by a rehabilitation program pertinent to upper limb motor function exercise and mental imagery (EMI) as well as lryperbaric oxygen therapy (HBOT). We assessed feasibility and safety of the combined approach utilizing both HBOT and EMI, and to derive preliminary estimates of its efficacy. In this randomized controlled trial, 27 patients with upper extremity hemiparesis at 3-48 months after stroke were randomized to receive either a complementary rehabilitation program of HBOT-EMI (intervention group), or EMI alone (control group). Feasibility and safety were assessed as total session attendance, duration of sessions, attrition rates, missing data, and intervention-related adverse events. Secondary clinical outcomes were assessed with both objective tools and self-reported measures at baseline, 8 weeks (end of treatment), and 12-weeks thllow-up. Session attendance, duration, and attrition rate did not differ between the groups; there were no serious adverse events. Compared with baseline, there were significant sustained improvements of objective and subjective outcomes' measures in the intervention group, and a single improvement in an objective measure in the control group. Between-group outcome comparisons were not statistically significant. This study demonstrated that the combination HBOT-EMI was a safe and feasible approach in patients recovering from chronic stroke. There were also trends for improved motor function of the affected upper limb after the treatments. Novelty HBOT combined with an upper limb exercise and mental imagery rehabilitation program is feasible and safe in chronic stroke patients. This combined approach showed trends for improved functional recovery. AD - [Schiavo, S.; Uehling, J.; Carroll, J.; Clarke, H.; Djaiani, C.; Gershinsky, M.; Katznelson, R.] Univ Hlth Network, Toronto Gen Hosp, Dept Anesthesia & Pain Management, Hyperbar Med Unit, Toronto, ON M5G 2C4, Canada. [Richardson, D.] Toronto Rehabil Inst, Stroke Rehabil Clin, Toronto, ON M5G 2C4, Canada. [Santa Mina, D.; Buryk-Iggers, S.] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON M5G 2C1, Canada. [Santa Mina, D.] Univ Toronto, Fac Med, Dept Surg, Toronto, ON M5G 2C1, Canada. [Santa Mina, D.] Princess Margaret Canc Ctr Toronto, Dept Support Care, Toronto, ON M5G 2C1, Canada. Katznelson, R (corresponding author), Univ Hlth Network, Toronto Gen Hosp, Dept Anesthesia & Pain Management, Hyperbar Med Unit, Toronto, ON M5G 2C4, Canada. rita.katznelson@uhn.ca AN - WOS:000596591500005 AU - Schiavo, S. AU - Richardson, D. AU - Santa Mina, D. AU - Buryk-Iggers, S. AU - Uehling, J. AU - Carroll, J. AU - Clarke, H. AU - Djaiani, C. AU - Gershinsky, M. AU - Katznelson, R. DA - Dec DO - 10.1139/apnm-2020-0124 J2 - Appl. Physiol. Nutr. Metab. KW - hyperbaric oxygen therapy stroke rehabilitation stroke rehabilitation GRASP exercise therapy motor function MONTREAL COGNITIVE ASSESSMENT ISCHEMIA-REPERFUSION INJURY POST-CONCUSSION SYNDROME NITRIC-OXIDE ARM FUNCTION SAMPLE-SIZE BLOCK TEST THERAPY NEUROPLASTICITY ANGIOGENESIS Nutrition & Dietetics Physiology Sport Sciences LA - English M1 - 12 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2020 SN - 1715-5312 SP - 1345-1352 ST - Hyperbaric oxygen and focused rehabilitation program: a feasibility study in improving upper limb motor function after stroke T2 - Applied Physiology Nutrition and Metabolism TI - Hyperbaric oxygen and focused rehabilitation program: a feasibility study in improving upper limb motor function after stroke UR - ://WOS:000596591500005 VL - 45 ID - 931987 ER - TY - JOUR AB - See PDF, links to possible relevant studies AU - Sexton, Tyler. L1 - internal-pdf://3494161756/Sexton.pdf PY - 2020 ST - Hyperbarics in Traumatic Brain Injury TI - Hyperbarics in Traumatic Brain Injury ID - 932061 ER - TY - JOUR AB - Traumatic brain injury (TBI) may cause persistent cognitive dysfunction. A pilot clinical study was performed to determine if hyperbaric oxygen (HBO2) treatment improves cognitive performance. It was hypothesized that stem cells, mobilized by HBO2 treatment, are recruited to repair damaged neuronal tissue. This hypothesis was tested by measuring the relative abundance of stem cells in peripheral blood and cognitive performance during this clinical trial. The subject population consisted of 28 subjects with persistent cognitive impairment caused by mild to moderate TBI suffered during military deployment to Iraq or Afghanistan. Fluorescence-activated cell sorting (FACS) analysis was performed for stem cell markers in peripheral blood and correlated with variables resulting from standard tests of cognitive performance and post-traumatic stress disorder: ImPACT, BrainCheckers and PCL-M test results. HBO2 treatment correlated with stem cell mobilization as well as increased cognitive performance. Together these results support the hypothesis that stem cell mobilization may be required for cognitive improvement in this population. AD - [Shandley, Sabrina; Prye, Jennifer; Arizpe, Helen M.; Kalns, John] Hyper Biotechnol Inc, San Antonio, TX USA. [Wolf, E. George; Richards, Michael F.] Hyperbar Med, Med Wing 59, Jbsa Lackland, TX 78236 USA. [Schubert-Kabban, Christine M.] US Air Force, Inst Technol, Wright Patterson AFB, OH 45433 USA. [Baugh, Laura M.] Med Specialty Squadron, Jbsa Lackland, TX USA. Wolf, EG (corresponding author), Hyperbar Med, Med Wing 59, Jbsa Lackland, TX 78236 USA. earl.g.wolf.ctr@mail.mil AN - WOS:000402225600006 AU - Shandley, S. AU - Wolf, E. G. AU - Schubert-Kabban, C. M. AU - Baugh, L. M. AU - Richards, M. F. AU - Prye, J. AU - Arizpe, H. M. AU - Kalns, J. DA - May-Jun J2 - Undersea Hyperb. Med. KW - stem cell traumatic brain injury neurocognitive assessment cognitive performance hyperbaric oxygen HBO2 TBI PTSD BONE-MARROW MICROGLIA MOBILIZATION TRIAL Marine & Freshwater Biology Medicine, Research & Experimental LA - English M1 - 3 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2017 SN - 1066-2936 SP - 257-269 ST - Increased circulating stem cells and better cognitive performance in traumatic brain injury subjects following hyperbaric oxygen therapy T2 - Undersea and Hyperbaric Medicine TI - Increased circulating stem cells and better cognitive performance in traumatic brain injury subjects following hyperbaric oxygen therapy UR - ://WOS:000402225600006 VL - 44 ID - 932010 ER - TY - JOUR AB - Traumatic brain injury (TBI) may cause persistent cognitive dysfunction. A pilot clinical study was performed to determine if hyperbaric oxygen (HBO₂) treatment improves cognitive performance. It was hypothesized that stem cells, mobilized by HBO₂ treatment, are recruited to repair damaged neuronal tissue. This hypothesis was tested by measuring the relative abundance of stem cells in peripheral blood and cognitive performance during this clinical trial. The subject population consisted of 28 subjects with persistent cognitive impairment caused by mild to moderate TBI suffered during military deployment to Iraq or Afghanistan. Fluorescence-activated cell sorting (FACS) analysis was performed for stem cell markers in peripheral blood and correlated with variables resulting from standard tests of cognitive performance and post-traumatic stress disorder: ImPACT, BrainCheckers and PCL-M test results. HBO₂ treatment correlated with stem cell mobilization as well as increased cognitive performance. Together these results support the hypothesis that stem cell mobilization may be required for cognitive improvement in this population. AD - Hyperion Biotechnology, Inc., San Antonio, Texas, U.S. 59th Medical Wing, Hyperbaric Medicine, JBSA-Lackland, Texas U.S. U.S. Air Force Institute of Technology, Wright-Patterson AFB, Ohio, U.S. Medical Specialty Squadron, JBSA-Lackland, Texas U.S. AN - 28779582 AU - Shandley, S. AU - Wolf, E. G. AU - Schubert-Kappan, C. M. AU - Baugh, L. M. AU - Richards, M. F. AU - Prye, J. AU - Arizpe, H. M. AU - Kalns, J. DA - May-Jun DO - 10.22462/5.6.2017.6 DP - NLM ET - 2017/08/06 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - AC133 Antigen Afghan Campaign 2001- Antigens, CD34 Brain Injuries, Traumatic/blood/complications/*therapy Cell Movement/*physiology Cognition/*physiology Cognition Disorders/blood/etiology/*therapy Double-Blind Method Flow Cytometry Humans *Hyperbaric Oxygenation Iraq War, 2003-2011 *Military Personnel Nestin/analysis Neural Stem Cells/*physiology Pilot Projects Statistics, Nonparametric Hbo₂ Ptsd Tbi cognitive performance hyperbaric oxygen neurocognitive assessment stem cell traumatic brain injury submission. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2017 SN - 1066-2936 (Print) 1066-2936 SP - 257-269 ST - Increased circulating stem cells and better cognitive performance in traumatic brain injury subjects following hyperbaric oxygen therapy T2 - Undersea Hyperb Med TI - Increased circulating stem cells and better cognitive performance in traumatic brain injury subjects following hyperbaric oxygen therapy VL - 44 ID - 931869 ER - TY - JOUR AB - Despite multiple prior pharmacological trials in traumatic brain injury (TBI), the search for an effective, safe, and practical treatment of these patients remains ongoing. Given the ease of delivery and rapid absorption into the systemic circulation, inhalational gases that have neuroprotective properties will be an invaluable resource in the clinical management of TBI patients. In this review, we perform a systematic review of both pre-clinical and clinical reports describing inhalational gas therapy in the setting of TBI. Hyperbaric oxygen, which has been investigated for many years, and some of the newest developments are reviewed. Also, promising new therapies such as hydrogen gas, hydrogen sulfide gas, and nitric oxide are discussed. Moreover, novel therapies such as xenon and argon gases and delivery methods using microbubbles are explored. AD - Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. AN - 33940933 AU - Shin, S. S. AU - Hwang, M. AU - Diaz-Arrastia, R. AU - Kilbaugh, T. J. DA - Jun 8 DO - 10.1089/neu.2021.0053 DP - NLM ET - 2021/05/05 J2 - Journal of neurotrauma KW - head trauma oxidative stress traumatic brain injury LA - eng N1 - PubMed (NLM) literature search June 18, 2021 PY - 2021 SN - 0897-7151 ST - Inhalational Gases for Neuroprotection in Traumatic Brain Injury T2 - J Neurotrauma TI - Inhalational Gases for Neuroprotection in Traumatic Brain Injury ID - 931877 ER - TY - JOUR AB - Returning veterans are frequently diagnosed with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Considering a recent case-controlled study of hyperbaric oxygen therapy (HBOT) reporting a reduction in suicidal ideation, we investigated retrospectively three veterans with chronic TBI/PTSD symptoms who were treated with multiple rounds of HBOT with neurophysiological testing performed before and after treatment. Improvements were detected on parameters within neurocognitive domains, including reductions in suicide-related symptoms. These findings independently confirm that HBOT may be effective in treating specific symptoms of TBI/PTSD that are not currently addressed with existing therapeutic approaches. AD - 1 Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, USA. 2 Neurological Solutions, Inc., Palm Harbor, USA. AN - 31134828 AU - Shytle, R. D. AU - Eve, D. J. AU - Kim, S. H. AU - Spiegel, A. AU - Sanberg, P. R. AU - Borlongan, C. V. C2 - Pmc6719491 DA - Jul DO - 10.1177/0963689719853232 DP - NLM ET - 2019/05/29 J2 - Cell transplantation KW - Adult Brain Injuries, Traumatic/*therapy Female Humans Hyperbaric Oxygenation/*methods Male Retrospective Studies Stress Disorders, Post-Traumatic/*therapy Veterans *hyperbaric oxygen therapy *post traumatic stress disorder *traumatic brain injury *war veterans conflicts of interest with respect to the research, authorship, and/or publication of this article: PRS is the Co-Editor-in-Chief of Cell Transplantation. Neither PRS nor any colleagues of PRS had any direct role in the peer review process for this commentary piece. LA - eng M1 - 7 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 0963-6897 (Print) 0963-6897 SP - 885-892 ST - Retrospective Case Series of Traumatic Brain Injury and Post-Traumatic Stress Disorder Treated with Hyperbaric Oxygen Therapy T2 - Cell Transplant TI - Retrospective Case Series of Traumatic Brain Injury and Post-Traumatic Stress Disorder Treated with Hyperbaric Oxygen Therapy VL - 28 ID - 931865 ER - TY - JOUR AB - We report results of an observational cohort study investigating long-term follow-up in participants from two completed United States military trials of hyperbaric oxygen (HBO₂) for persistent post-concussive symptoms (PCS), as well as challenges in recruitment and retention in active-duty military personnel. After informed consent, participants completed an electronic survey assessing PCS, post-traumatic stress disorder (PTSD), anxiety, depression and quality of life. Of 132 HBO₂ study participants, 40 (30%) completed the survey (42 could not be contacted; 50 were lost to follow-up or declined). All were male, age 28.1 ±6.6 years (mean ±1SD). Time to follow-up was 39.2 ±6.1 months. At follow-up, participants reported continued symptoms of PTSD, depression, anxiety and reduced quality of life. Among DARPA/VCU study participants, total PCS scores worsened in the 1.5 atmospheres absolute (ATA) equivalent HBO₂ group (mean change 7.4 ±15.8) and improved in the sham (-8.0 ±7.7) and 2.0 atmospheres absolute equivalent HBO₂ groups (-3.3 ±7.4). Individual changes varied widely, range -23 to +28 points. In participants from the HOPPS study, total PCS scores worsened in all groups: local care (10.5 ±8.7), sham (7.9 ±11.9) and 1.5 ATA HBO₂ (1.0 ±19.4). In this limited, cross-sectional sample, PCS and PTSD symptoms did not appear to improve over time by descriptive analyses. Low participation rates and potential response bias limit our ability to perform statistical hypothesis testing and to draw conclusions from these data. Future studies should prospectively plan longitudinal follow-up and regular engagement with participants to minimize attrition. AD - Hyperbaric Oxygen Project Office, US Army Medical Materiel Development Activity (USAMMDA), Fort Detrick, Maryland U.S. Neurotrauma and Psychological Health USAMMDA, Fort Detrick, Maryland U.S. Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah U.S. The Emmes Corporation, Rockville, Maryland U.S. AN - 28768076 AU - Skipper, L. D. AU - Churchill, S. AU - Wilson, S. H. AU - Deru, K. AU - Labutta, R. J. AU - Hart, B. B. DA - Aug-Sept DP - NLM ET - 2017/08/03 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Atmospheric Pressure Brain Concussion/*complications Central Nervous System Agents/therapeutic use Cross-Sectional Studies Follow-Up Studies Humans *Hyperbaric Oxygenation Male Middle Aged *Military Personnel Patient Dropouts/statistics & numerical data Patient Selection Post-Concussion Syndrome/etiology/*therapy Quality of Life Treatment Outcome United States attrition mild traumatic brain injury post-concussive syndrome retention submission. LA - eng M1 - 5 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 601-613 ST - Hyperbaric oxygen for persistent post-concussive symptoms: long-term follow-up T2 - Undersea Hyperb Med TI - Hyperbaric oxygen for persistent post-concussive symptoms: long-term follow-up VL - 43 ID - 931845 ER - TY - JOUR AD - Dept. of Hyperbaric Medicine, No.401 Hospital of the People's Liberation Army, Qingdao, 266071, China. Dept. of Hyperbaric Medicine, No.1 Sanatorium of Chinese Navy, Qingdao, 266071, China. AN - 28777524 AU - Sun, Q. AU - Sun, Z. AU - Gao, G. DA - Nov-Dec DP - NLM ET - 2017/08/05 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - *Brain Concussion Humans *Hyperbaric Oxygenation Oxygen LA - eng M1 - 7 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 855-856 ST - The sham control settings in hyperbaric oxygen trials T2 - Undersea Hyperb Med TI - The sham control settings in hyperbaric oxygen trials VL - 43 ID - 931878 ER - TY - JOUR AB - BACKGROUND: Traumatic brain injury (TBI) is one of the important causes of morbidity and mortality throughout the world, especially in young people. In recent years normobaric hyperoxia has become an important and useful step for recovery and improvement of outcome in TBI. OBJECTIVES: The purpose of this study was to evaluate the effects of normobaric hyperoxia on clinical neurological outcomes of patients with severe traumatic brain injuries. We used the Glasgow outcome scale (GOS), barthel index, and modified rankin scale (mRS) to measure the outcomes of patients with TBI. PATIENTS AND METHODS: Sixty-eight consecutive patients with severe TBI (mean Glasgow coma scale [GCS] score: 7.4) who met the inclusion criteria were entered in this randomized controlled clinical trial. The patients were randomized into two groups, as follows: 1) experimental: received 80% oxygen via mechanical ventilator in the first 6 hours of admission, 2) control: received 50% oxygen by mechanical ventilator in the first 6 hours of admission and then standard medical care. We measured the GOS, Barthel Index, and mRS at the time of discharge from hospital and reassessed these measurements at the 6-month follow-up after injury. RESULTS: According to our study, there were no significant sex or age differences between the two groups (P = 0.595 and 0.074). The number of days in the intensive care unit (ICU) in the control group and experimental group were 11.4 and 9.4 days, respectively (P = 0.28), while the numbers of days of general ward admission were 13.9 and 11.4 days (P = 0.137) respectively. The status of GOS at time of discharge were severe = 13 and 10, moderate = 16 and 19, and low = 5 and 5 in the control and experimental groups, respectively (P = 0.723); 6 months after injury, the scores were as follows: moderate = 16 and 9, low = 15 and 25, and severe = 3 and 0 (P = 0.024). The Barthel index scores in the control and experimental groups were 59.7 and 63.9 at time of discharge (P = 0.369) and 82.7 and 91.3 at 6 months after injury (P = 0.018), respectively. The mRS results were 2.6 and 2.3 at time of discharge (P = 0.320) and 1.6 and 0.7 at 6 months after injury (P = 0.006) for the control and experimental groups, respectively. CONCLUSIONS: According to the results of this study, oxygen therapy by mechanical ventilator in the first 6 hours after injury in patients with severe TBI can improve the final GOS, Barthel index, and mRS scores. It could also improve long-term outcomes and enhance rehabilitation and the quality of life. AD - Department of Anesthesiology and Critical Care, Hamadan University of Medical Sciences, Hamadan, IR Iran. Department of Epidemiology, Modeling of Noncommunicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences, Hamadan, IR Iran. Department of Neurosurgery, Hamadan University of Medical Sciences, Hamadan, IR Iran. AN - 27218057 AU - Taher, A. AU - Pilehvari, Z. AU - Poorolajal, J. AU - Aghajanloo, M. C2 - Pmc4869427 DA - Feb DO - 10.5812/traumamon.26772 DP - NLM ET - 2016/05/25 J2 - Trauma monthly KW - Brain Injuries Glasgow Outcome Scale Hyperbaric Oxygenation Oxygen Inhalation Therapy LA - eng M1 - 1 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 2251-7464 (Print) 2251-7472 SP - e26772 ST - Effects of Normobaric Hyperoxia in Traumatic Brain Injury: A Randomized Controlled Clinical Trial T2 - Trauma Mon TI - Effects of Normobaric Hyperoxia in Traumatic Brain Injury: A Randomized Controlled Clinical Trial VL - 21 ID - 931864 ER - TY - JOUR AU - Terada, Masafumi AU - Musculoskeletal, Health AU - Movement Science Laboratory, University of Toledo O. H. AU - Pietrosimone, Brian G. AU - Musculoskeletal, Health AU - Movement Science Laboratory, University of Toledo O. H. AU - Gribble, Phillip A. AU - Musculoskeletal, Health AU - Movement Science Laboratory, University of Toledo O. H. DO - 10.4085/1062-6050-48.4.11 M1 - 5 PY - 2021 SN - 1062-6050 SP - 696-709 ST - Therapeutic Interventions for Increasing Ankle Dorsiflexion After Ankle Sprain: A Systematic Review T2 - Journal of Athletic Training TI - Therapeutic Interventions for Increasing Ankle Dorsiflexion After Ankle Sprain: A Systematic Review UR - https://meridian.allenpress.com/jat/article-pdf/48/5/696/1610306/1062-6050-48_4_11.pdf VL - 48 ID - 932056 ER - TY - GEN AN - NCT01220713 AU - University, Virginia Commonwealth AU - United States Naval Medical Center, Portsmouth AU - Center, Hunter Holmes Mcguire Veteran Affairs Medical DA - June KW - Mild Traumatic Brain Injury|Post-Concussive Syndrome N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT01220713 PY - 2010 ST - hbot TI - Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI) ID - 932043 ER - TY - JOUR AB - Background: The Brain uses 20% of the total oxygen supply consumed by the entire body. Even though, <10% of the brain is active at any given time, it utilizes almost all the oxygen delivered. In order to perform complex tasks or more than one task (multitasking), the oxygen supply is shifted from one brain region to another, via blood perfusion modulation. The aim of the present study was to evaluate whether a hyperbaric oxygen (HBO) environment, with increased oxygen supply to the brain, will enhance the performance of complex and/or multiple activities. Methods: A prospective, double-blind randomized control, crossover trial including 22 healthy volunteers. Participants were asked to perform a cognitive task, a motor task and a simultaneous cognitive-motor task (multitasking). Participants were randomized to perform the tasks in two environments: (a) normobaric air (1 ATA 21% oxygen) (b) HBO (2 ATA 100% oxygen). Two weeks later participants were crossed to the alternative environment. Blinding of the normobaric environment was achieved in the same chamber with masks on while hyperbaric sensation was simulated by increasing pressure in the first minute and gradually decreasing to normobaric environment prior to tasks performance. Results: Compared to the performance at normobaric conditions, both cognitive and motor single tasks scores were significantly enhanced by HBO environment (p < 0.001 for both). Multitasking performance was also significantly enhanced in HBO environment (p = 0.006 for the cognitive part and p = 0.02 for the motor part). Conclusions: The improvement in performance of both single and multi-tasking while in an HBO environment supports the hypothesis which according to, oxygen is indeed a rate limiting factor for brain activity. Hyperbaric oxygenation can serve as an environment for brain performance. Further studies are needed to evaluate the optimal oxygen levels for maximal brain performance. AD - [Vadas, Dor] Israeli Rehabil Ctr Stroke & Brain Injury, Rehovot, Israel. [Kalichman, Leonid] Ben Gurion Univ Negev, Recanati Sch Community Hlth Profess, Fac Hlth Sci, Dept Phys Therapy, Beer Sheva, Israel. [Hadanny, Amir; Efrati, Shai] Asaf Harofeh Med Ctr, Sagol Ctr Hyperbar Med & Res, Zerifin, Israel. [Hadanny, Amir; Efrati, Shai] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel. [Hadanny, Amir] Bar Ilan Univ, Galilee Fac Med, Ramat Gan, Israel. [Efrati, Shai] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel. Vadas, D (corresponding author), Israeli Rehabil Ctr Stroke & Brain Injury, Rehovot, Israel.; Efrati, S (corresponding author), Asaf Harofeh Med Ctr, Sagol Ctr Hyperbar Med & Res, Zerifin, Israel.; Efrati, S (corresponding author), Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.; Efrati, S (corresponding author), Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel. dorvadas@gmail.com; efratishai@013.net AN - WOS:000411943100001 AU - Vadas, D. AU - Kalichman, L. AU - Hadanny, A. AU - Efrati, S. C7 - 25 DA - Sep DO - 10.3389/fnint.2017.00025 J2 - Front. Integr. Neurosci. KW - HBOT hyperbaric oxygenation dual tasking oxygen limitation enhancing brain activity POST-CONCUSSION SYNDROME MOTOR-ASSESSMENT SCALE DEAD-SEA LOW-ALTITUDE TASK REHABILITATION Behavioral Sciences Neurosciences LA - English M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2017 SN - 1662-5145 SP - 6 ST - Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance T2 - Frontiers in Integrative Neuroscience TI - Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance UR - ://WOS:000411943100001 VL - 11 ID - 932005 ER - TY - JOUR AB - STUDY OBJECTIVE: In this exploratory, double-blind, longitudinal sham-controlled trial of hyperbaric oxygen (HBO(2)) for military personnel with post concussive mild traumatic brain injury (mTBI), self-reports and objective measures of sleep-wake disturbances were assessed and compared to normals. METHODS: Self-reports consisting of Pittsburg Sleep Quality Index (PSQI), sleep diary, screening for obstructive sleep apnea (OSA) risk, restless legs syndrome (RLS), cataplexy, and objective actigraphic measures of sleep-wake were obtained on 71 military personnel with mTBI [baseline, 13 weeks and six months post-randomization (post-intervention)], of which 35 met post-traumatic stress disorder (PTSD) criteria, and 75 healthy volunteers (baseline). Baseline between-group and follow-up changes from baseline overall and within subgroups were evaluated. Mild TBI was defined as consisting of head injury associated loss of consciousness (<24 h), post-traumatic amnesia, and neurological deficits. RESULTS: Sleep quality by self-reports was markedly degraded in the mTBI group at baseline compared to a normative cohort; insomnia 87.3 versus 2.8%, OSA risk 70% versus 1.3%, RLS 32.4% versus and 2.7%. (all p-values <0.001), but actigraphy measures did not differentiate between groups. HBO(2) compared to sham treatment improved self-reports of PSQI sleep measures, reports (five out of eight at 13-weeks and two out of eight at six-months). However, other sleep-wake measures were not different. CONCLUSIONS: Perceived sleep quality was markedly disrupted in mTBI military personnel and sleep-wake disturbances were prevalent compared to a normative cohort. HBO(2) relative to sham improved some measures of sleep quality on the PSQI, but other measures of sleep were not significantly different. AD - PSG Professional Services, Inc, Farmington, UT, USA. The Emmes Corporation, Rockville, MD, USA. Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, UT, USA; Division of Hyperbaric Medicine, Intermountain LDS Hospital, Salt Lake City, USA; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address: lindell.weaver@imail.org. AN - 30099354 AU - Walker, J. M. AU - Mulatya, C. AU - Hebert, D. AU - Wilson, S. H. AU - Lindblad, A. S. AU - Weaver, L. K. DA - Nov DO - 10.1016/j.sleep.2018.06.006 DP - NLM ET - 2018/08/14 J2 - Sleep medicine KW - Adult Brain Injuries, Traumatic/*complications Cataplexy/diagnosis Cohort Studies Female Humans Hyperbaric Oxygenation/*methods Longitudinal Studies Male Military Personnel/*statistics & numerical data Post-Concussion Syndrome/*etiology Restless Legs Syndrome/diagnosis Self Report Sleep Apnea, Obstructive/diagnosis Sleep Initiation and Maintenance Disorders/diagnosis Sleep Wake Disorders/*etiology Stress Disorders, Post-Traumatic/diagnosis/etiology *Actigraphy *Hyperbaric *Psqi *Self-report *Sleep *Tbi LA - eng N1 - PubMed (NLM) literature search June 18, 2021 PY - 2018 SN - 1389-9457 SP - 66-79 ST - Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls T2 - Sleep Med TI - Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls VL - 51 ID - 931861 ER - TY - JOUR AB - Compelling evidence suggests the advantage of hyperbaric oxygen therapy (HBOT) in traumatic brain injury. The present meta-analysis evaluated the outcomes of HBOT in patients with traumatic brain injury (TBI). Prospective studies comparing hyperbaric oxygen therapy vs. control in patients with mild (GCS 13-15) to severe (GCS 3-8) TBI were hand-searched from medical databases using the terms "hyperbaric oxygen therapy, traumatic brain injury, and post-concussion syndrome". Glasgow coma scale (GCS) was the primary outcome, while Glasgow outcome score (GOS), overall mortality, and changes in post-traumatic stress disorder (PTSD) score, constituted the secondary outcomes. The results of eight studies (average age of patients, 23-41 years) reveal a higher post-treatment GCS score in the HBOT group (pooled difference in means = 3.13, 95 % CI 2.34-3.92, P < 0.001), in addition to greater improvement in GOS and lower mortality, as compared to the control group. However, no significant change in the PTSD score was observed. Patients undergoing hyperbaric therapy achieved significant improvement in the GCS and GOS with a lower overall mortality, suggesting its utility as a standard intensive care regimen in traumatic brain injury. AD - [Wang, Fei; Wang, Yong; Sun, Tao; Yu, Hua-lin] Kunming Med Univ, Affiliated Hosp 1, Dept Neurosurg 2, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China. Yu, HL (corresponding author), Kunming Med Univ, Affiliated Hosp 1, Dept Neurosurg 2, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China. hualin_yu@sina.com AN - WOS:000378045500005 AU - Wang, F. AU - Wang, Y. AU - Sun, T. AU - Yu, H. L. DA - May DO - 10.1007/s10072-015-2460-2 J2 - Neurol. Sci. KW - Glasgow coma scale Glasgow outcome score Oxygen therapy Post-concussion syndrome Traumatic brain injury CEREBRAL METABOLISM INTRACRANIAL-PRESSURE NORMOBARIC HYPEROXIA SYMPTOMS TRIAL Clinical Neurology Neurosciences LA - English M1 - 5 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2016 SN - 1590-1874 SP - 693-701 ST - Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis T2 - Neurological Sciences TI - Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis UR - ://WOS:000378045500005 VL - 37 ID - 932016 ER - TY - JOUR AB - Objective: This study was designed to investigate the protective functions and specific mechanisms of hyperbaric oxygenation (HBO) treatment on traumatic brain injury (TBI) by detecting the effects of HBO treatment on the apoptosis of nerve cells, the expressions of apoptotic genes and apoptosis-related genes in the posterior cerebral cortex and hippocampus, and expression of NF-κB (p-p65) in hippocampus in newborn rats after TBI. Methods: Ninety six healthy 7-day-old newborn Sprague-Dawley (SD) rats were randomly divided into sham operation group (n=32), TBI group (n=32) and TBI+HBO group (n=32). The changes of relevant indexes were observed at four time points (8 h, 16 h, 24 h, and 48 h) after HBO treatment. Theterminal-deoxynucleotidyl transferase mediated dUTP nickendlabeling (TUNEL) method was employed to detect the apoptosis of nerve cells; the real-time fluorescent quantitative PCR (qPCR) method was applied to detect the change rule of apoptosis-related genes (Bcl-2, Bax) and the Western Blot (WB) assay was adopted to detect the expression of NF-κB (p-p65) in hippocampus. Results: In sham operation group, there were no significant differences in the apoptosis of nerve cells and the expressions of apoptosis-related genes among each observation time (P>0.05). Compared with sham operation group, whether in cerebral cortex or hippocampus in TBI group, the number of apoptotic nerve cells was significantly increased (P<0.01), and the Bcl-2/Bax ratio was substantially decreased while this trend was on the rise over time. Compared with TBI group, the apoptosis of nerve cells in cerebral cortex and hippocampus in TBI+HBO group were significantly decreased (P<0.05), and the Bcl-2/Bax ratio was substantially increased (P<0.01). Compared to sham operation group, the expression of NF-κB (p-p65) in TBI group was significantly increased (all P<0.01); and the expression of NF-κB (p-p65) was substantially decreased after HBO treatment (all P<0.05). Conclusion: As a treatment which can effectively relieve the apoptosis of nerve cells in newborn rats after TBI, and weaken the expression of NF-κB (pp65), HBO has apparently protective effects on brain tissues after TBI. AD - H. Yang, Department of Emergency Medicine, Yantaishan Hospital, No. 91 Jiefang Road, Zhifu District, Yantai, Shandong, China AU - Wang, K. AU - Wang, Y. AU - Yang, H. DB - Embase KW - messenger RNA protein Bax protein bcl 2 transcription factor RelA animal experiment animal model animal tissue apoptosis article brain cortex controlled study gene expression hippocampus hyperbaric oxygen therapy nerve cell newborn nonhuman protein expression rat real time polymerase chain reaction Sprague Dawley rat traumatic brain injury TUNEL assay Western blotting LA - English M1 - 10 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 1940-5901 SP - 14555-14562 ST - Effects of HBO on apoptosis of nerve cells and expression of NF-κB after TBI in neonatal rats T2 - International Journal of Clinical and Experimental Medicine TI - Effects of HBO on apoptosis of nerve cells and expression of NF-κB after TBI in neonatal rats UR - https://www.embase.com/search/results?subaction=viewrecord&id=L619032514&from=export VL - 10 ID - 931909 ER - TY - JOUR AB - Objective: This study was designed to investigate the protective functions and specific mechanisms of hyperbaric oxygenation (HBO) treatment on traumatic brain injury (TBI) by detecting the effects of HBO treatment on the apoptosis of nerve cells, the expressions of apoptotic genes and apoptosis-related genes in the posterior cerebral cortex and hippocampus, and expression of NF-kappa B (p-p65) in hippocampus in newborn rats after TBI. Methods: Ninety six healthy 7-day-old newborn Sprague-Dawley (SD) rats were randomly divided into sham operation group (n=32), TBI group (n=32) and TBI+HBO group (n=32). The changes of relevant indexes were observed at four time points (8 h, 16 h, 24 h, and 48 h) after HBO treatment. Theterminal-deoxynucleotidyl transferase mediated dUTP nickendlabeling (TUNEL) method was employed to detect the apoptosis of nerve cells; the real-time fluorescent quantitative PCR (qPCR) method was applied to detect the change rule of apoptosis-related genes (Bcl-2, Bax) and the Western Blot (WB) assay was adopted to detect the expression of NF-kappa B (p-p65) in hippocampus. Results: In sham operation group, there were no significant differences in the apoptosis of nerve cells and the expressions of apoptosis-related genes among each observation time (P>0.05). Compared with sham operation group, whether in cerebral cortex or hippocampus in TBI group, the number of apoptotic nerve cells was significantly increased (P<0.01), and the Bcl-2/Bax ratio was substantially decreased while this trend was on the rise over time. Compared with TBI group, the apoptosis of nerve cells in cerebral cortex and hippocampus in TBI+ HBO group were significantly decreased (P<0.05), and the Bcl-2/Bax ratio was substantially increased (P<0.01). Compared to sham operation group, the expression of NF-kappa B (p-p65) in TBI group was significantly increased (all P<0.01); and the expression of NF-kappa B (p-p65) was substantially decreased after HBO treatment (all P<0.05). Conclusion: As a treatment which can effectively relieve the apoptosis of nerve cells in newborn rats after TBI, and weaken the expression of NF-kappa B (p-p65), HBO has apparently protective effects on brain tissues after TBI. AD - [Wang, Ke; Yang, Haiyan] Yantaishan Hosp, Dept Emergency Med, 91 Jiefang Rd, Yantai 246000, Shandong, Peoples R China. [Wang, Yan] Yantaishan Hosp, Dept Orthopaed, Yantai, Shandong, Peoples R China. Yang, HY (corresponding author), Yantaishan Hosp, Dept Emergency Med, 91 Jiefang Rd, Yantai 246000, Shandong, Peoples R China. haiyanyang2017@163.com AN - WOS:000414299700044 AU - Wang, K. AU - Wang, Y. AU - Yang, H. Y. J2 - Int. J. Clin. Exp. Med. KW - Hyperbaric oxygenation (HBO) newborn rats traumatic brain injury (TBI) apoptosis of nerve cells Bcl-2/Bax NF-kappa B (p-p65) TRAUMATIC BRAIN-INJURY TLR4/NF-KAPPA-B SIGNALING PATHWAY HYPERBARIC OXYGENATION BCL-2 BAX GENES MODULATION ACTIVATION CASPASE-3 MELATONIN Medicine, Research & Experimental LA - English M1 - 10 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2017 SN - 1940-5901 SP - 14555-14562 ST - Effects of HBO on apoptosis of nerve cells and expression of NF-kappa B after TBI in neonatal rats T2 - International Journal of Clinical and Experimental Medicine TI - Effects of HBO on apoptosis of nerve cells and expression of NF-kappa B after TBI in neonatal rats UR - ://WOS:000414299700044 VL - 10 ID - 932011 ER - TY - GEN AN - NCT01925963 AU - Weaver, Lindell AU - Research, U.S. Army Medical AU - Command, Development AU - The Emmes Company, LLC AU - Intermountain Health Care, Inc. AU - Hospital, Evans Army Community DA - January 10 KW - Focus: Healthy Adults Without Brain Injury N1 - Clinicaltrials.gov literature search Date last searched June 18, 2021 PB - https://ClinicalTrials.gov/show/NCT01925963 PY - 2014 ST - normal TI - Normative Datasets for Assessments Planned for Mild Traumatic Brain Injury (NORMAL) ID - 932053 ER - TY - JOUR AB - The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) study, sponsored by the Department of Defense and held under an investigational new drug application by the Office of the Army Surgeon General, is one of the largest and most complex clinical trials of hyperbaric oxygen (HBO₂) for post-concussive symptoms (PCS) in U.S. military service members. AD - Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah U.S. University of Utah School of Medicine, Salt Lake City, Utah U.S. U.S. Army Medical Materiel Development Activity (USAMMDA), Hyperbaric Oxygen Research Program Management Office (HBO₂ PMO), Fort Detrick, Maryland U.S. The Emmes Corporation, Rockville, Maryland U.S. AN - 28768068 AU - Weaver, L. K. AU - Chhoeu, A. AU - Lindblad, A. S. AU - Churchill, S. AU - Deru, K. AU - Wilson, S. H. DA - Aug-Sept DP - NLM ET - 2017/08/03 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Blast Injuries/complications Brain Concussion/*complications/physiopathology Electroencephalography Female Heart Rate/physiology Humans *Hyperbaric Oxygenation Male Middle Aged *Military Personnel Neurologic Examination Post-Concussion Syndrome/etiology/physiopathology/*therapy Sleep Wake Disorders/diagnosis/etiology Vestibular Diseases/diagnosis Young Adult baseline hyperbaric oxygen mild traumatic brain injury traumatic brain injury submission. LA - eng M1 - 5 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 485-489 ST - Executive summary: The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) Study T2 - Undersea Hyperb Med TI - Executive summary: The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) Study VL - 43 ID - 931874 ER - TY - JOUR AB - The Brain Injury and Mechanisms of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) study, sponsored by the Department of Defense, is a randomized double-blind, sham-controlled clinical trial that has a longer duration of follow-up and more comprehensive assessment battery compared to recent HBO₂ studies. BIMA randomized 71 participants from September 2012 to May 2014. Primary results are expected in 2017. Randomized military personnel received hyperbaric oxygen (HBO₂) at 1.5 atmospheres absolute (ATA) or sham chamber sessions at 1.2 ATA, air, for 60 minutes daily for 40 sessions. Outcomes include neuropsychological, neuroimaging, neurological, vestibular, autonomic function, electroencephalography, and visual systems evaluated at baseline, immediately following intervention at 13 weeks and six months with self-report symptom and quality of life questionnaires at 12 months, 24 months and 36 months. Characteristics include: median age 33 years (range 21-53); 99% male; 82% Caucasian; 49% diagnosed post-traumatic stress disorder; 28% with most recent injury three months to one year prior to enrollment; 32% blast injuries; and 73% multiple injuries. This manuscript describes the study design, outcome assessment battery, and baseline characteristics. Independent of a therapeutic role of HBO₂, results of BIMA will aid understanding of mTBI. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01611194; https://clinicaltrials.gov/show/NCT01611194. AD - Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah U.S. University of Utah School of Medicine, Salt Lake City, Utah U.S. U.S. Army Medical Materiel Development Activity (USAMMDA), Hyperbaric Oxygen Research Program Management Office (HBO₂ PMO), Fort Detrick, Maryland U.S. The Emmes Corporation, Rockville, Maryland U.S. AN - 28768069 AU - Weaver, L. K. AU - Chhoeu, A. AU - Lindblad, A. S. AU - Churchill, S. AU - Wilson, S. H. DA - Aug-Sept DP - NLM ET - 2017/08/03 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Brain Concussion/*complications Double-Blind Method Female Humans Hyperbaric Oxygenation/adverse effects/*methods Intention to Treat Analysis Male Middle Aged *Military Personnel Multiple Trauma *Outcome Assessment, Health Care Post-Concussion Syndrome/etiology/*therapy *Research Design Safety *brain concussion *hyperbaric oxygenation *methodology *post-concussive syndrome submission. LA - eng M1 - 5 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 491-509 ST - Hyperbaric oxygen for mild traumatic brain injury: Design and baseline summary T2 - Undersea Hyperb Med TI - Hyperbaric oxygen for mild traumatic brain injury: Design and baseline summary VL - 43 ID - 931846 ER - TY - JOUR AB - INTRODUCTION: Global outcomes can strengthen inferences from clinical trials. We evaluate global outcomes for persistent post-concussive symptoms (PCS) after mild traumatic brain injury (mTBI) in two clinical trials of hyperbaric oxygen (HBO2) in United States service members. METHODS: During study design, outcomes of symptom, cognitive, and functional impairments planned for a trial of HBO2 for PCS (HOPPS) were weighted and grouped into different domains to formulate the composite outcome total score. The composite outcome was compared between the intervention groups in HOPPS and those in a subsequent HBO2 trial (BIMA) for validation. Additionally, two post hoc global outcome measures were explored, including one composed of components that demonstrated favorable characteristics in both studies and another via components used in another TBI randomized trial (COBRIT). RESULTS: In total, 143 active-duty or veteran military personnel were randomized across the two studies. Composite total scores improved from baseline for HBO2 (mean ± SD -2.9±9.0) and sham (-2.9±6.6) groups in HOPPS but did not differ significantly between groups (p=0.33). In BIMA, 13-week changes from baseline favored the HBO2 group (-3.6±6.4) versus sham (-0.3±5.2; p=0.02). No between-group differences were found when COBRIT composite scoring was applied to BIMA. Overall, HBO2 effects were maximized when the post hoc global measure derived from both studies was applied to the data. CONCLUSIONS: Composite total scores in HOPPS and BIMA were consistent with primary study results. The global measures considered may offer utility as endpoints to achieve maximal HBO2 effect in future trials of the mTBI population. IDS: clinicaltrials.gov Identifiers NCT01611194 (BIMA) and NCT01306968 (HOPPS). AD - Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain LDS Hospital, Salt Lake City, Utah U.S. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah U.S. Emmes, Rockville, Maryland U.S. AN - 31394603 AU - Weaver, L. K. AU - Churchill, S. AU - Wilson, S. H. AU - Hebert, D. AU - Deru, K. AU - Lindblad, A. S. DA - BIMA Special Edition No. Feb DP - NLM ET - 2019/08/09 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adolescent Adult Aged Aged, 80 and over Algorithms Brain Concussion/complications Cognition Female Humans *Hyperbaric Oxygenation/adverse effects Male Middle Aged Military Personnel Outcome Assessment, Health Care/*methods Post-Concussion Syndrome/*therapy Research Design Time Factors Veterans Young Adult composite outcome hyperbaric oxygenation mild traumatic brain injury submission. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 1066-2936 (Print) 1066-2936 SP - 341-352 ST - A composite outcome for mild traumatic brain injury in trials of hyperbaric oxygen T2 - Undersea Hyperb Med TI - A composite outcome for mild traumatic brain injury in trials of hyperbaric oxygen VL - 46 ID - 931840 ER - TY - JOUR AB - Introduction: Even though mild traumatic brain injury is common and can result in persistent symptoms, traditional measurement tools can be insensitive in detecting functional deficits after injury. Some newer assessments do not have well-established norms, and little is known about how these measures perform over time or how cross-domain assessments correlate with one another. We conducted an exploratory study to measure the distribution, stability, and correlation of results from assessments used in mild traumatic brain injury in healthy, community-dwelling adults. Materials and Methods: In this prospective cohort study, healthy adult men and women without a history of brain injury underwent a comprehensive brain injury evaluation that included self-report questionnaires and neurological, electroencephalography, sleep, audiology/vestibular, autonomic, visual, neuroimaging, and laboratory testing. Most testing was performed at 3 intervals over 6 months. Results: The study enrolled 83 participants, and 75 were included in the primary analysis. Mean age was 38 years, 58 were male, and 53 were civilians. Participants did not endorse symptoms of post-concussive syndrome, PTSD, or depression. Abnormal neurological examination findings were rare, and 6 had generalized slowing on electroencephalography. Actigraphy and sleep diary showed good sleep maintenance efficiency, but 21 reported poor sleep quality. Heart rate variability was most stable over time in the sleep segment. Dynavision performance was normal, but 41 participants had abnormal ocular torsion. On eye tracking, circular, horizontal ramp, and reading tasks were more likely to be abnormal than other tasks. Most participants had normal hearing, videonystagmography, and rotational chair testing, but computerized dynamic posturography was abnormal in up to 21% of participants. Twenty-two participants had greater than expected white matter changes for age by MRI. Most abnormal findings were dispersed across the population, though a few participants had clusters of abnormalities. Conclusions: Despite our efforts to enroll normal, healthy volunteers, abnormalities on some measures were surprisingly common. AD - [Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] Intermt Med Ctr, Div Hyperbar Med, Murray, UT 84107 USA. [Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] Intermt LDS Hosp, Salt Lake City, UT 84143 USA. [Weaver, Lindell K.; Mirow, Susan] Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT 84112 USA. [Wilson, Steffanie H.; Lindblad, Anne S.] Emmes Corp, Rockville, MD USA. [Price, Robert] Evans Army Community Hosp, Ft Carson, CO USA. [Williams, Christopher S.; Orrison, William W.; Patel, Jigar B.; Walker, James M.; Meehan, Anna; Mirow, Susan] Lovelace Biomed Res, Albuquerque, NM USA. Weaver, LK (corresponding author), Intermt Med Ctr, Div Hyperbar Med, Murray, UT 84107 USA.; Weaver, LK (corresponding author), Intermt LDS Hosp, Salt Lake City, UT 84143 USA.; Weaver, LK (corresponding author), Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT 84112 USA. lindell.weaver@imail.org AN - WOS:000453363000001 AU - Weaver, L. K. AU - Wilson, S. H. AU - Lindblad, A. S. AU - Churchill, S. AU - Deru, K. AU - Price, R. AU - Williams, C. S. AU - Orrison, W. W. AU - Patel, J. B. AU - Walker, J. M. AU - Meehan, A. AU - Mirow, S. AU - Team, Normal Study C7 - 1030 DA - Dec DO - 10.3389/fneur.2018.01030 J2 - Front. Neurol. KW - neurological evaluation healthy volunteers neuroepidemiology white matter hyperintensities brain imaging mild traumatic brain injury WHITE-MATTER HYPERINTENSITIES HEART-RATE-VARIABILITY POST-CONCUSSIVE SYMPTOMS OBSTRUCTIVE SLEEP-APNEA HYPERBARIC-OXYGEN PSYCHOMETRIC PROPERTIES SERVICE MEMBERS PTSD CHECKLIST INTER-SCANNER QUALITY INDEX Clinical Neurology Neurosciences LA - English M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2018 SN - 1664-2295 SP - 25 ST - Comprehensive Evaluation of Healthy Volunteers Using Multi-Modality Brain Injury Assessments: An Exploratory, Observational Study T2 - Frontiers in Neurology TI - Comprehensive Evaluation of Healthy Volunteers Using Multi-Modality Brain Injury Assessments: An Exploratory, Observational Study UR - ://WOS:000453363000001 VL - 9 ID - 931997 ER - TY - JOUR AB - Background: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBOâ‚‚) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. Methods: This Phase II, randomized, double‐blind, sham‐controlled trial enrolled military personnel with mild TBI and persistent post‐concussive symptoms. Participants were randomized to receive 40 HBOâ‚‚ (1.5 atmospheres absolute (ATA), ⟩99% oxygen, 60 minutes) or sham chamber sessions (1.2 ATA, room air, 60 minutes) over 12 weeks. Participants and evaluators were blinded to allocation. Outcomes assessed at baseline, 13 weeks and six months included symptoms, quality of life, neuropsychological, neurological, electroencephalography, sleep, auditory, vestibular, autonomic, visual, neuroimaging, and laboratory testing. Participants completed 12‐month questionnaires. Intention‐to‐treat results are reported. Results: From 9/11/2012 to 5/19/2014, 71 randomized participants received HBOâ‚‚ (n=36) or sham (n=35). At baseline, 35 participants (49%) met post‐traumatic stress disorder (PTSD) criteria. By the Neurobehavioral Symptom Inventory, the HBOâ‚‚ group had improved 13‐week scores (mean change ‐3.6 points, P=0.03) compared to sham (+3.9 points). In participants with PTSD, change with HBOâ‚‚ was more pronounced (‐8.6 vs. +4.8 points with sham, P=0.02). PTSD symptoms also improved in the HBOâ‚‚ group, and more so in the subgroup with PTSD. Improvements regressed at six and 12 months. Hyperbaric oxygen improved some cognitive processing speed and sleep measures. Participants with PTSD receiving HBOâ‚‚ had improved functional balance and reduced vestibular complaints at 13 weeks. Conclusions: By 13 weeks, HBOâ‚‚ improved post‐concussive and PTSD symptoms, cognitive processing speed, sleep quality, and balance function, most dramatically in those with PTSD. Changes did not persist beyond six months. Several outcomes appeared sensitive to change; additional studies are warranted. AN - CN-01959875 AU - Weaver, L. K. AU - Wilson, S. H. AU - Lindblad, A. S. AU - Churchill, S. AU - Deru, K. AU - Price, R. C. AU - Williams, C. S. AU - Orrison, W. W. AU - Walker, J. M. AU - Meehan, A. AU - et al. KW - *United States *hyperbaric oxygen therapy *military service *postconcussion syndrome Adult Ambient air Article Atmosphere Brain Concussion [*complications] Controlled study Double blind procedure Double‐Blind Method Drug therapy Electroencephalography Female Human Humans Hyperbaric Oxygenation [*methods, statistics & numerical data] Intention to Treat Analysis Laboratory test Major clinical study Male Mental Status and Dementia Tests Middle Aged Military Personnel Nervous system Neuroimaging Outcome assessment Phase 2 clinical trial Posttraumatic stress disorder Post‐Concussion Syndrome [etiology, *therapy] Processing speed Quality of Life Questionnaire Randomized controlled trial Single blind procedure Sleep quality Soldier Stress Disorders, Post‐Traumatic [etiology, therapy] Symptom Assessment Time Factors Traumatic brain injury Treatment Outcome United States Walk Test Young Adult M1 - 2 M3 - Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial N1 - Cochrane CENTRAL (Wiley) Literature search June 18, 2021 PY - 2018 SP - 129‐156 ST - Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial T2 - Undersea & hyperbaric medicine TI - Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial UR - https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01959875/full VL - 45 ID - 931965 ER - TY - JOUR AB - BACKGROUND: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO₂) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. METHODS: This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms. Participants were randomized to receive 40 HBO₂ (1.5 atmospheres absolute (ATA), ⟩99% oxygen, 60 minutes) or sham chamber sessions (1.2 ATA, room air, 60 minutes) over 12 weeks. Participants and evaluators were blinded to allocation. Outcomes assessed at baseline, 13 weeks and six months included symptoms, quality of life, neuropsychological, neurological, electroencephalography, sleep, auditory, vestibular, autonomic, visual, neuroimaging, and laboratory testing. Participants completed 12-month questionnaires. Intention-to-treat results are reported. RESULTS: From 9/11/2012 to 5/19/2014, 71 randomized participants received HBO₂ (n=36) or sham (n=35). At baseline, 35 participants (49%) met post-traumatic stress disorder (PTSD) criteria. By the Neurobehavioral Symptom Inventory, the HBO₂ group had improved 13-week scores (mean change -3.6 points, P=0.03) compared to sham (+3.9 points). In participants with PTSD, change with HBO₂ was more pronounced (-8.6 vs. +4.8 points with sham, P=0.02). PTSD symptoms also improved in the HBO₂ group, and more so in the subgroup with PTSD. Improvements regressed at six and 12 months. Hyperbaric oxygen improved some cognitive processing speed and sleep measures. Participants with PTSD receiving HBO₂ had improved functional balance and reduced vestibular complaints at 13 weeks. CONCLUSIONS: By 13 weeks, HBO₂ improved post-concussive and PTSD symptoms, cognitive processing speed, sleep quality, and balance function, most dramatically in those with PTSD. Changes did not persist beyond six months. Several outcomes appeared sensitive to change; additional studies are warranted. AD - Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah. University of Utah School of Medicine, Salt Lake City, Utah. The Emmes Corporation, Rockville, Maryland. Evans Army Community Hospital, Fort Carson, Colorado. Lovelace Biomedical Research, Albuquerque, New Mexico. AN - 29734566 AU - Weaver, L. K. AU - Wilson, S. H. AU - Lindblad, A. S. AU - Churchill, S. AU - Deru, K. AU - Price, R. C. AU - Williams, C. S. AU - Orrison, W. W. AU - Walker, J. M. AU - Meehan, A. AU - Mirow, S. DA - Mar-Apr DP - NLM ET - 2018/05/08 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Brain Concussion/*complications Double-Blind Method Female Humans Hyperbaric Oxygenation/*methods/statistics & numerical data Intention to Treat Analysis Male Mental Status and Dementia Tests Middle Aged *Military Personnel Post-Concussion Syndrome/etiology/*therapy Quality of Life Stress Disorders, Post-Traumatic/etiology/therapy Symptom Assessment Time Factors Treatment Outcome United States Walk Test Young Adult BIMA study Nct01611194 www.ClinicalTrials.gov submission. LA - eng M1 - 2 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2018 SN - 1066-2936 (Print) 1066-2936 SP - 129-156 ST - Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial T2 - Undersea Hyperb Med TI - Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial VL - 45 ID - 931850 ER - TY - JOUR AB - Background: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO2) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. Methods: This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms. Participants were randomized to receive 40 HBO2 (1.5 atmospheres absolute (ATA), >99% oxygen, 60 minutes) or sham chamber sessions (1.2 ATA, room air, 60 minutes) over 12 weeks. Participants and evaluators were blinded to allocation. Outcomes assessed at baseline, 13 weeks and six months included symptoms, quality of life, neuropsychological, neurological, electroencephalography, sleep, auditory, vestibular, autonomic, visual, neuroimaging, and laboratory testing. Participants completed 12-month questionnaires. Intention-to-treat results are reported. Results: From 9/11/2012 to 5/19/2014, 71 randomized participants received HBO2 (n=36) or sham (n=35). At baseline, 35 participants (49%) met post-traumatic stress disorder (PTSD) criteria. By the Neurobehavioral Symptom Inventory, the HBO2 group had improved 13-week scores (mean change -3.6 points, P=0.03) compared to sham (+3.9 points). In participants with PTSD, change with HBO2 was more pronounced (-8.6 vs. +4.8 points with sham, P=0.02). PTSD symptoms also improved in the HBO2 group, and more so in the subgroup with PTSD. Improvements regressed at six and 12 months. Hyperbaric oxygen improved some cognitive processing speed and sleep measures. Participants with PTSD receiving HBO2 had improved functional balance and reduced vestibular complaints at 13 weeks. Conclusions: By 13 weeks, HBO2 improved post-concussive and PTSD symptoms, cognitive processing speed, sleep quality, and balance function, most dramatically in those with PTSD. Changes did not persist beyond six months. Several outcomes appeared sensitive to change; additional studies are warranted. AD - [Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] Intermt Med Ctr, Div Hyperbar Med, Murray, UT 84107 USA. [Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] Intermt LDS Hosp, Salt Lake City, UT 84143 USA. [Weaver, Lindell K.; Mirow, Susan] Univ Utah, Sch Med, Salt Lake City, UT 84112 USA. [Wilson, Steffanie H.; Lindblad, Anne S.] Emmes Corp, Rockville, MD USA. [Price, Robert C.] Evans Army Community Hosp, Ft Carson, CO USA. [Williams, Chris S.; Orrison, William W.; Walker, James M.; Meehan, Anna; Mirow, Susan] Lovelace Biomed Res, Albuquerque, NM USA. Weaver, LK (corresponding author), Intermt Med Ctr, Div Hyperbar Med, Murray, UT 84107 USA.; Weaver, LK (corresponding author), Intermt LDS Hosp, Salt Lake City, UT 84143 USA.; Weaver, LK (corresponding author), Univ Utah, Sch Med, Salt Lake City, UT 84112 USA. lindell.weaver@imail.org AN - WOS:000431655500001 AU - Weaver, L. K. AU - Wilson, S. H. AU - Lindblad, A. S. AU - Churchill, S. AU - Deru, K. AU - Price, R. C. AU - Williams, C. S. AU - Orrison, W. W. AU - Walker, J. M. AU - Meehan, A. AU - Mirow, S. AU - Team, Bima Study DA - Mar-Apr J2 - Undersea Hyperb. Med. KW - TRAUMATIC BRAIN-INJURY PERSISTENT POSTCONCUSSION SYMPTOMS OF-DEFENSE TRIALS HEAD-INJURY SLEEP-DISORDERS TBI ISSUES RELIABILITY DESIGN QUESTIONNAIRE VALIDITY Marine & Freshwater Biology Medicine, Research & Experimental LA - English M1 - 2 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2018 SN - 1066-2936 SP - 129-156 ST - Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial T2 - Undersea and Hyperbaric Medicine TI - Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial UR - ://WOS:000431655500001 VL - 45 ID - 932003 ER - TY - JOUR AB - Objective: To explore the value of the quantification of blood-brain barrier and cytotoxic edema at the early period after traumatic brain injury (TBI) in prediction of the neurofunction recovery related to hyperbaric oxygen (HBO) treatment. Methods: Twenty-one rabbits were randomly divided into TBI+HBO group (n=15) and sham+HBO group (n=6). The TBI+HBO group received TBI induced by a modified weight drop device and sham+HBO group received no TBI. Both groups received a total of 10 times HBO treatments within 7 days after TBI. MRI was performed at 3 h, 1 day, 3 days, 7 days, 30 days after TBI. Also the standardized veterinary coma scale (VCS) was performed on pre-TBI, 1 day and 30 days after TBI. Results: The VCS score of TBI+HBO group at 1 day and 30 days were both lower than pre-TBI (P=0.001), but the VCS score at 30 days was higher than 1 day (P=0.001). The volume transfer coefficient (Ktrans) value at 1 day and 3 days in the focal lesion area were negative correlated with the VCS score at 30 days (both P<0.05), but there was no correlation at 3 h with VCS score at 30 days (P=0.064). And the ADC value at 1 day and 3 days in the focal lesion area were positive correlated with the VCS score at 30 days (both P<0.05). The Ktrans value at 1 day in the perifocal area was negative correlated with the VCS score at 30 days (P<0.05), but there was no correlation at 3 days with VCS score at 30 days (P=0.078). The ADC value at 3 day in the perifocal area were negative correlated with the VCS score at 30 days (P<0.05), and there were no correlation at 1 day and 7 days with VCS score at 30 days (P=0.085, 0.057). Conclusion: The quantification of focal lesion and perifocal areas at the acute phase after TBI can predicte the functional outcome. AD - W. Li, Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China AU - Wei, X. AU - Li, Y. AU - Zhao, H. AU - Fu, M. AU - Li, W. DB - Embase DO - 10.13929/j.1003-3289.2016.06.004 KW - animal experiment animal model article blood brain barrier brain function controlled study correlation analysis cytotoxicity edema hyperbaric oxygen therapy nonhuman nuclear magnetic resonance imaging predictive value prognosis quantitative analysis Leporidae rating scale traumatic brain injury LA - Chinese M1 - 6 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1003-3289 SP - 829-834 ST - Quantitative MRI after hyperbaric oxygen in prediction of neurofunction prognosis of traumatic brain injury T2 - Chinese Journal of Medical Imaging Technology TI - Quantitative MRI after hyperbaric oxygen in prediction of neurofunction prognosis of traumatic brain injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L614404446&from=export http://dx.doi.org/10.13929/j.1003-3289.2016.06.004 VL - 32 ID - 931938 ER - TY - JOUR AB - Purpose: Mild Traumatic Brain Injury (mTBI) among combat personnel deployed in confiict areas of the Middle East has significantly increased due to exposure to explosive blasts. These injuries can lead to physiological and psychological effects including oculomotor deficits. Last year we presented results on the effects of mTBI on eye movements during reading (Wetzel, et al. ARVO 2012). The aim of this study is to examine the effects of mTBI on saccadic response during horizontal (H) and vertical (V) tracking as a further objective measure of mTBI. Methods: In an ongoing double-blind study, the eye movements of 60 active duty Marines (20 to 34 yrs) diagnosed with mTBI from 3 to 24 months before initial measurement and a control group (n = 6) from 18 to 21 years were binocularly recorded with stabilized head at 500 Hz (SR Research). In separate trials, participants were instructed to track spatially and temporally randomized step changes in target position along the H and V axes. The eye movements of the Marines were recorded before assignment to one of 3 treatment categories: Hyperbaric Oxygen Therapy at one of two treatment levels and a sham condition. Within 2 weeks of completing treatment, the Marines were retested (n = 31) and were tested again after roughly 3 months (n = 30). Data were analyzed for response latency, number of saccades, saccadic amplitude, duration, velocity and acceleration, including position accuracy and fixation stability. Statistical analysis was performed on all eye measurement parameters using ANOVA. Results: While dissimilarities persist in all eye movement parameters, significant dissimilarities were found in both the H and V stimuli group. Differences in saccadic duration were not significant for H saccades but were for V saccades. Peak velocities for H saccades were significantly slower for mTBIs compared to controls. In both stimulus directions, significant differences were found in both peak acceleration and deceleration. The number and mean saccadic amplitude between controls and mTBIs were not significant. Fixation RMS velocity in controls was significantly less implying less stable fixation for those with mTBI. Within the mTBI group, V data was more likely to show potential treatment effects compared to H data. Conclusions: Combat-related mTBI produces similar but unequal effects on saccadic response in both the H and V directions. Fixation stability may also be an important indicator of mTBI status. AD - P. Wetzel, Dept. of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States AU - Wetzel, P. AU - Pallansch, R. AU - Gitchel, G. AU - Cifu, D. DB - Embase KW - adult analysis of variance clinical article conference abstract controlled study deceleration disease course double blind procedure female head human hyperbaric oxygen therapy male neuroophthalmology optometry randomized controlled trial reaction time saccadic eye movement traumatic brain injury LA - English M1 - 15 M3 - Conference Abstract N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2013 SN - 1552-5783 ST - The effect of combat-related mild TBI on saccadic eye movements T2 - Investigative Ophthalmology and Visual Science TI - The effect of combat-related mild TBI on saccadic eye movements UR - https://www.embase.com/search/results?subaction=viewrecord&id=L628584322&from=export VL - 54 ID - 931951 ER - TY - JOUR AB - Purpose: Eye movements may offer a sensitive method to measure response to intervention in mild traumatic brain injury (mTBI). Methods: The Brain Injury and Mechanisms of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury Study (BIMA) randomized 71 participants to 40 sessions of hyperbaric oxygen or sham. A companion normative study (Normal) enrolled 75 participants. An eye tracking system measured left and right eye movements for saccadic and smooth pursuit. At baseline two smooth pursuit tasks, circular and horizontal ramp, and four saccadic tasks, horizontal and vertical step, reading, and memory guided-on tasks differentiated BIMA from Normal participants. The change from baseline in these tasks were measured and compared between interventions and against Normal participants at 13 weeks and six-month follow-up using the two-sample t-test. The Holm-Bonferroni procedure was used to adjust for multiple testing. Results: Change from baseline in eyetracker measures for participants assigned to the hyperbaric oxygen arm did not significantly differ from those assigned to the sham arm at post-randomization time points 13 weeks and six months. Consistent shifts of BIMA participant values toward Normal values at 13 weeks and six months were observed for overall fixation duration, forward saccadic duration, and number of lines read for the reading task, number of misses on the memory guided-on task, and absolute intersaccadic interval velocity and absolute saccadic amplitude on the circular task. The distributions between Normal and BIMA participants were no longer statistically significantly different at 13 weeks and six months post enrollment for these measures. Conclusions: The baseline differences between BIMA and Normal suggest potential vulnerability of the smooth pursuit system and the saccadic system. During the six-month follow-up period, improvement toward Normal was seen on some measures in both the hyperbaric oxygen and sham intervention arms without difference between intervention groups. AD - [Wetzel, Paul A.] Lovelace Biomed & Environm Res Inst, Albuquerque, NM USA. [Wetzel, Paul A.; Kannan, Mary A.; Villamar, Zoe; Gitchel, George T.] Virginia Commonwealth Univ, Dept Biomed Engn, Richmond, VA USA. [Lindblad, Anne S.; Mulatya, Caroline] Emmes, Rockville, MD 20850 USA. [Weaver, Lindell K.] Intermt Med Ctr, Div Hyperbar Med, Murray, KY USA. [Weaver, Lindell K.] Intermt LDS Hosp, Salt Lake City, UT USA. [Weaver, Lindell K.] Univ Utah, Dept Med, Sch Med, Salt Lake City, UT USA. Lindblad, AS (corresponding author), Emmes, Rockville, MD 20850 USA. alindblad@emmes.com AN - WOS:000479124300008 AU - Wetzel, P. A. AU - Lindblad, A. S. AU - Mulatya, C. AU - Kannan, M. A. AU - Villamar, Z. AU - Gitchel, G. T. AU - Weaver, L. K. J2 - Undersea Hyperb. Med. KW - brain concussion eye tracking post-concussive syndrome smooth pursuit saccade TRAUMATIC BRAIN-INJURY TARGET SYNCHRONIZATION SMOOTH ABNORMALITIES Marine & Freshwater Biology Medicine, Research & Experimental LA - English M1 - 3 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2019 SN - 1066-2936 SP - 299-311 ST - Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms T2 - Undersea and Hyperbaric Medicine TI - Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms UR - ://WOS:000479124300008 VL - 46 ID - 931993 ER - TY - JOUR AB - PURPOSE: Eye movements may offer a sensitive method to measure response to intervention in mild traumatic brain injury (mTBI). METHODS: The Brain Injury and Mechanisms of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury Study (BIMA) randomized 71 participants to 40 sessions of hyperbaric oxygen or sham. A companion normative study (Normal) enrolled 75 participants. An eye tracking system measured left and right eye movements for saccadic and smooth pursuit. At baseline two smooth pursuit tasks, circular and horizontal ramp, and four saccadic tasks, horizontal and vertical step, reading, and memory guided-on tasks differentiated BIMA from Normal participants. The change from baseline in these tasks were measured and compared between interventions and against Normal participants at 13 weeks and six-month follow-up using the two-sample t-test. The Holm-Bonferroni procedure was used to adjust for multiple testing. RESULTS: Change from baseline in eyetracker measures for participants assigned to the hyperbaric oxygen arm did not significantly differ from those assigned to the sham arm at post-randomization time points 13 weeks and six months. Consistent shifts of BIMA participant values toward Normal values at 13 weeks and six months were observed for overall fixation duration, forward saccadic duration, and number of lines read for the reading task, number of misses on the memory guided-on task, and absolute intersaccadic interval velocity and absolute saccadic amplitude on the circular task. The distributions between Normal and BIMA participants were no longer statistically significantly different at 13 weeks and six months post enrollment for these measures. CONCLUSION: The baseline differences between BIMA and Normal suggest potential vulnerability of the smooth pursuit system and the saccadic system. During the six-month follow-up period, improvement toward Normal was seen on some measures in both the hyperbaric oxygen and sham intervention arms without difference between intervention groups. IDS: clinicaltrials.gov Identifiers NCT01611194 and NCT01925963. AD - Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico U.S. Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia U.S. Emmes, Rockville, Maryland U.S. Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain LDS Hospital, Salt Lake City, Utah U.S. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah U.S. AN - 31394600 AU - Wetzel, P. A. AU - Lindblad, A. S. AU - Mulatya, C. AU - Kannan, M. A. AU - Villmar, Z. AU - Gitchel, G. T. AU - Weaver, L. K. DA - BIMA Special Edition No. Feb DP - NLM ET - 2019/08/09 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adolescent Adult Aged Double-Blind Method *Eye Movement Measurements/instrumentation Eye Movements Female Fixation, Ocular Humans *Hyperbaric Oxygenation Male Memory Middle Aged Military Personnel Post-Concussion Syndrome/physiopathology/*therapy Prospective Studies *Pursuit, Smooth Reading *Saccades Stress Disorders, Post-Traumatic/physiopathology Time Factors Treatment Outcome Young Adult brain concussion eye tracking post-concussive syndrome saccade smooth pursuit submission. LA - eng M1 - 3 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2019 SN - 1066-2936 (Print) 1066-2936 SP - 299-311 ST - Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms T2 - Undersea Hyperb Med TI - Eye tracker outcomes in a randomized trial of 40 sessions of hyperbaric oxygen or sham in participants with persistent post concussive symptoms VL - 46 ID - 931848 ER - TY - JOUR AB - Undersea diving is a sport and commercial industry. Knowledge of potential problems began with Caisson disease or “the bends”, first identified with compressed air in the construction of tunnels under rivers in the 19th century. Subsequently, there was the commercially used old-fashioned diving helmet attached to a suit, with compressed air pumped down from the surface. Breathhold diving, with no supplementary source of air or other breathing mixture, is also a sport as well as a commercial fishing tool in some parts of the world. There has been an evolution to self-contained underwater breathing apparatus (SCUBA) diving with major involvement as a recreational sport but also of major commercial importance. Knowledge of the physiology and cardiovascular plus other medical problems associated with the various forms of diving have evolved extensively. The major medical catastrophes of SCUBA diving are air embolism and decompression sickness (DCS). Understanding of the essential referral to a hyperbaric recompression chamber for these problems is critical, as well as immediate measures until that recompression is achieved. These include the administration of 100% oxygen and rehydration with intravenous normal saline. Undersea diving continues to expand, especially as a sport, and a basic understanding of the associated preventive and emergency medicine will decrease complications and save lives. AD - T.F. Whayne, Department of Medicine (Cardiology), Division of Cardiovascular Medicine, Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States AU - Whayne, T. F. DB - Embase Medline DO - 10.2174/1570161115666170621084316 KW - hyperbaric chamber peripheral artery stent acetylsalicylic acid brain natriuretic peptide fluorocarbon hydroxymethylglutaryl coenzyme A reductase inhibitor methylprednisolone thrombocyte factor 4 vasodilator agent acute coronary syndrome air embolism brain hemorrhage breath holding cardiovascular effect cardiovascular magnetic resonance cerebrovascular accident cluster headache coronary artery occlusion decompression sickness diabetes mellitus diving echocardiography emergency medicine human hyperbaric oxygen therapy hypertension hypoxia lung artery pressure lung barotrauma lung edema microbubble migraine multiple sclerosis oxygen tension oxygen toxicity platelet count randomized controlled trial (topic) review risk management thrombin time traumatic brain injury wound healing LA - English M1 - 4 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2018 SN - 1875-6212 1570-1611 SP - 344-354 ST - Medical management and risk reduction of the cardiovascular effects of underwater diving T2 - Current Vascular Pharmacology TI - Medical management and risk reduction of the cardiovascular effects of underwater diving UR - https://www.embase.com/search/results?subaction=viewrecord&id=L622687925&from=export http://dx.doi.org/10.2174/1570161115666170621084316 VL - 16 ID - 931906 ER - TY - JOUR AB - Traumatic brain injury (TBI) continues to be a major public health problem. Proposed treatments have not withstood testing in clinical trials because of failure to account for different types of TBI and other weaknesses in trial design. Management goals continue to be prevention and prompt treatment of secondary insults (hypotension, hypoxia, and other physiologic derangements). This goal is best accomplished by careful attention to airway, breathing, circulation, and basic principles of intensive care unit management. Attempts to intervene prophylactically to prevent intracranial hypertension or other complications have not been beneficial and may even have deleterious effects. AD - A.B. Valadka AU - Whitaker-Lea, W. A. AU - Valadka, A. B. DB - Embase Medline DO - 10.1016/j.pmr.2016.12.002 KW - analgesic agent anticonvulsive agent heparin hypertensive factor low molecular weight heparin osmotic diuretic agent sedative agent steroid acute disease anamnesis brain damage brain hematoma brain injury clinical outcome compression stocking cranioplasty craniotomy decompressive craniectomy deep vein thrombosis device therapy disease classification disease marker disease severity dysautonomia emergency care emergency surgery fever follow up Glasgow coma scale human hyperbaric oxygen therapy hypotension intensive care intracranial hypertension neuroimaging neurophysiology neurosurgery nuclear magnetic resonance imaging outcome assessment pain patient assessment patient care patient monitoring physical examination practice guideline respiration control review seizure traumatic brain injury treatment response x-ray computed tomography LA - English M1 - 2 M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2017 SN - 1558-1381 1047-9651 SP - 227-243 ST - Acute Management of Moderate-Severe Traumatic Brain Injury T2 - Physical Medicine and Rehabilitation Clinics of North America TI - Acute Management of Moderate-Severe Traumatic Brain Injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L614641292&from=export http://dx.doi.org/10.1016/j.pmr.2016.12.002 VL - 28 ID - 931914 ER - TY - JOUR AB - The Brain Injury and Mechanisms of Action of HBO₂ for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (BIMA), sponsored by the Department of Defense, is a randomized, double-blind, sham-controlled trial of hyperbaric oxygen (HBO₂) in service members with persistent post-concussive symptoms following mild TBI, undergoing comprehensive assessments. The clinical EEG was assessed by neurologists for slow wave activity, ictal/interictal epileptiform abnormalities, and background periodic discharges. There is scant literature about EEG findings in this population, so we report baseline clinical EEG results and explore associations with other evaluations, including demographics, medication, neurological assessments, and clinical MRI outcomes. Seventy-one participants were enrolled: median age 32 years, 99% male, 49% comorbid PTSD, 28% with mTBI in the previous year, 32% blast injuries only, and 73% multiple injuries. All participants reported medication use (mean medications = 8, SD = 5). Slowing was present in 39%: generalized 37%, localized 8%, both 6%. No other abnormalities were identified. Slowing was not significantly associated with demographics, medication or neurological evaluation. Participants without EEG abnormalities paradoxically had significantly higher number of white matter hyperintensities as identified on MRI (p = 0.003). EEG slowing is present in more than one-third of participants in this study without evidence of associations with demographics, medications or neurological findings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01611194; https://clinicaltrials.gov/show/NCT01611194. AD - Lovelace Biomedical Research, Albuquerque, New Mexico U.S. CHMG Neurosciences, University of Colorado, Colorado Springs, Colorado U.S. University of Colorado Health Sciences Center, Aurora, Colorado, and Denver Veterans Affairs Medical Center, Denver, Colorado U.S. Rocky Mountain Neurological Associates, Intermountain LDS Hospital, Salt Lake City, Utah U.S. Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah U.S. University of Utah School of Medicine, Salt Lake City, Utah U.S. The Emmes Corporation, Rockville, Maryland U.S. AN - 28768071 AU - Williams, C. S. AU - Spitz, M. C. AU - Foley, J. F. AU - Weaver, L. K. AU - Lindblad, A. S. AU - Wierzbicki, M. R. DA - Aug-Sept DP - NLM ET - 2017/08/03 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Blast Injuries/complications Brain Concussion/*complications Double-Blind Method *Electroencephalography Female Humans Hyperbaric Oxygenation Magnetic Resonance Imaging Male *Military Personnel Post-Concussion Syndrome/diagnosis/etiology/*physiopathology/therapy Stress Disorders, Post-Traumatic/etiology * Eeg *mild traumatic brain injury *slowing submission. LA - eng M1 - 5 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 521-530 ST - Baseline EEG abnormalities in mild traumatic brain injury from the BIMA study T2 - Undersea Hyperb Med TI - Baseline EEG abnormalities in mild traumatic brain injury from the BIMA study VL - 43 ID - 931857 ER - TY - JOUR AB - Standard neurologic examinations may not detect abnormalities in U.S. military service members with persistent post-concussive symptoms following mild traumatic brain injury. The Brain Injury and Mechanisms of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury Study (BIMA) enrolled 71 participants September 2012-May 2014. Participants received: comprehensive neurological and oculomotor exam; balance testing (Berg Balance Scale-BBS; Romberg Test-RT, Sharpened Romberg Test-SRT); olfactory function (Brief Smell Identification Test-BSIT). Two trained neurologists conducted the examinations at a central facility in Colorado Springs. Median age was 32 years (range 21-53), 99% male, 82% Caucasian, 49% PTSD, 28% most recent qualifying injury three months to one year prior to enrollment, 32% blast injuries only, and 73% multiple injuries. Some participants presented with abnormal facial sensation (15%), abnormal tandem gait (13%), and tremor (11%). 54% had abnormal near point of convergence (abnormal range 13-80 cm). 86% scored ≥ 55 on the BBS, with no participant scoring ⟨ 50. 49% scored ⟨ 30 seconds on the best trial of the SRT. RT was abnormal in 10%. 15% of participants scored ≤ 9 (out of 12) on BSIT, about twice what is expected in a normal population. The neurological examination found abnormalities across a range of testing, with convergence insufficiency and SRT having the most sensitivity. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01611194; https://clinicaltrials.gov/show/NCT01611194. AD - Lovelace Biomedical Research, Albuquerque, New Mexico U.S. CHMG Neurosciences, University of Colorado, Colorado Springs, Colorado U.S. Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah U.S. University of Utah School of Medicine, Salt Lake City, Utah U.S. The Emmes Corporation, Rockville, Maryland U.S. Neurology, Evans Army Community Hospital, Ft. Carson, Colorado U.S. AN - 28768070 AU - Williams, C. S. AU - Weaver, L. K. AU - Lindblad, A. S. AU - Kumar, S. AU - Langford, D. R. DA - Aug-Sept DP - NLM ET - 2017/08/03 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Blast Injuries/*complications Brain Concussion/*complications Female Hand Strength/physiology Humans Hyperbaric Oxygenation Male Middle Aged *Military Personnel Multiple Trauma/complications Neurologic Examination/*methods Neuropsychological Tests Post-Concussion Syndrome/*diagnosis Postural Balance Reaction Time Sensation Disorders/diagnosis Smell Stress Disorders, Post-Traumatic/diagnosis Visual Acuity Walk Test *brain concussion *neurological examination *post-concussive syndrome submission. LA - eng M1 - 5 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 511-519 ST - Baseline neurological evaluations in a hyperbaric trial of post-concussive syndrome T2 - Undersea Hyperb Med TI - Baseline neurological evaluations in a hyperbaric trial of post-concussive syndrome VL - 43 ID - 931855 ER - TY - JOUR AB - Results of studies addressing the effect of mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) on symptoms and neuropsychological assessments are mixed regarding cognitive deficits in these populations. Neuropsychological assessments were compared between U.S. military service members with mTBI only (n=36) vs. those with mTBI÷ PTSD (n=35) from a randomized interventional study of mTBI participants with persistent post-concussive symptoms (PCS). The mTBI group endorsed worse symptoms than published norms on PCS, PTSD and pain scales (⟩50% abnormal on Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Civilian, McGill Pain Questionnaire-Short Form) and some quality of life domains. Worse symptom reporting was found in the mTBI÷ PTSD group compared to mTBI (e.g., mean NSI total score in mTBI 27.5 (SD=12.7), mTBI÷ PTSD 39.9 (SD=13.6), p⟨0.001). The mTBI÷PTSD group performed worse than mTBI on the Weschler Adult Intelligence Scale digit span (mean difference -1.5, 95% CI[-2.9,-0.1], p=0.04) and symbol search (mean difference -1.5, 95% CI[-2.7,-0.2], p=0.03) and Grooved Pegboard (dominant hand mean difference -7.0, 95% CI[-11.5,-2.4], p=0.003; non-dominant mean difference -9.8, 95% CI[-14.9,-4.7], p⟨0.001). Differences were detected in ANAM simple reaction time (p=0.04) and mathematical processing (p=0.03) but not verbal fluency or visuospatial memory assessments. Results indicate increased symptom severity and some cognitive deficits in mTBI÷ PTSD compared to mTBI alone. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01611194; https://clinicaltrials.gov/show/NCT01611194. AD - The Emmes Corporation, Rockville, Maryland U.S. Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah, and Intermountain LDS Hospital, Salt Lake City, Utah U.S. Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah U.S. AN - 28768075 AU - Wilson, S. H. AU - Weaver, L. K. AU - Lindblad, A. S. DA - Aug-Sept DP - NLM ET - 2017/08/03 J2 - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc KW - Adult Brain Concussion/*complications Depression/diagnosis Female Humans Hyperbaric Oxygenation Male Middle Aged *Military Personnel *Neuropsychological Tests Post-Concussion Syndrome/complications/*diagnosis/therapy *Quality of Life Randomized Controlled Trials as Topic Stress Disorders, Post-Traumatic/complications/*diagnosis Surveys and Questionnaires *brain concussion *methodology *neuropsychology *post-concussion syndrome submission. LA - eng M1 - 5 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1066-2936 (Print) 1066-2936 SP - 585-599 ST - Neuropsychological assessments in a hyperbaric trial of post-concussive symptoms T2 - Undersea Hyperb Med TI - Neuropsychological assessments in a hyperbaric trial of post-concussive symptoms VL - 43 ID - 931853 ER - TY - JOUR AB - Hyperbaric oxygen (HBO) therapy and neural stem cell (NSC) transplantation can improve traumatic brain injury (TBI) clinically. This study aimed to investigate the mechanism of HBO promoting NSC proliferation and neurological recovery after TBI. Twenty-four Sprague-Dawley rats were divided randomly into three groups: a sham group, a TBI group (constructed using Feeney's free-fall method), and an HBO-treated TBI group. Neurological function was evaluated by Neurological Severity Scores on days 1, 3, and 7, and we found that TBI-induced poor neurological function was improved by HBO. On day 7 after TBI, we observed that TBI promoted NSC proliferation, migration to the lesion area, and the levels of vascular endothelial growth factor (VEGF), VEGFR2, Raf-1, MEK1/2, and phospho-extracellular signal-regulated kinase (ERK) 1/2 protein, which were further boosted by HBO, from immunohistochemistry, immunofluorescence, and Western blot experiments. In vitro, cell injury was applied to NSCs isolated from neonatal Sprague-Dawley rats by the Cell Injury Controller II system. Moreover, data from the BrdU Kit and Western blot showed that in-vitro HBO significantly accelerated NSC proliferation and the levels of proteins related to cell cycle and the VEGF/ERK pathway after cell injury, which was suppressed by the VEGFR2 inhibitor. Taken together, this study indicated that HBO may promote NSC proliferation by activating VEGF/ERK signaling and play a crucial role in neuroprotection after TBI. AD - aDepartment of Neurosurgery, The First Hospital of Fuzhou City Affiliated Fujian Medical University bDepartment of Neurosurgery Research Institute of Fujian Province, Fuzhou, China. AN - 28953090 AU - Yang, Y. AU - Wei, H. AU - Zhou, X. AU - Zhang, F. AU - Wang, C. DA - Dec 13 DO - 10.1097/wnr.0000000000000901 DP - NLM ET - 2017/09/28 J2 - Neuroreport KW - Animals Brain Infarction/chemically induced/diagnosis *Brain Injuries, Traumatic/metabolism/pathology/therapy Bromodeoxyuridine/metabolism Cell Proliferation/drug effects/*physiology Cells, Cultured Disease Models, Animal Extracellular Signal-Regulated MAP Kinases/*metabolism Gene Expression Regulation/drug effects/physiology Hyperbaric Oxygenation/methods Male Neural Stem Cells/drug effects/*physiology Neurologic Examination Oxygen/pharmacology Rats Rats, Sprague-Dawley Signal Transduction/*drug effects/physiology Time Factors Vascular Endothelial Growth Factor A/*metabolism LA - eng M1 - 18 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2017 SN - 0959-4965 SP - 1232-1238 ST - Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury T2 - Neuroreport TI - Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury VL - 28 ID - 931868 ER - TY - JOUR AB - Hyperbaric oxygen (HBO) therapy and neural stem cell (NSC) transplantation can improve traumatic brain injury (TBI) clinically. This study aimed to investigate the mechanism of HBO promoting NSC proliferation and neurological recovery after TBI. Twenty-four Sprague-Dawley rats were divided randomly into three groups: a sham group, a TBI group (constructed using Feeney's free-fall method), and an HBO-treated TBI group. Neurological function was evaluated by Neurological Severity Scores on days 1, 3, and 7, and we found that TBI-induced poor neurological function was improved by HBO. On day 7 after TBI, we observed that TBI promoted NSC proliferation, migration to the lesion area, and the levels of vascular endothelial growth factor (VEGF), VEGFR2, Raf-1, MEK1/2, and phospho-extracellular signal-regulated kinase (ERK) 1/2 protein, which were further boosted by HBO, from immunohistochemistry, immunofluorescence, and Western blot experiments. In vitro, cell injury was applied to NSCs isolated from neonatal Sprague-Dawley rats by the Cell Injury Controller II system. Moreover, data from the BrdU Kit and Western blot showed that in-vitro HBO significantly accelerated NSC proliferation and the levels of proteins related to cell cycle and the VEGF/ERK pathway after cell injury, which was suppressed by the VEGFR2 inhibitor. Taken together, this study indicated that HBO may promote NSC proliferation by activating VEGF/ERK signaling and play a crucial role in neuroprotection after TBI. AD - [Yang, Yongkai; Wei, Hao; Zhou, Xiaohui; Zhang, Fan] Fujian Med Univ, Hosp Fuzhou City Affiliated 1, Dept Neurosurg, Fuzhou 350009, Fujian, Peoples R China. [Wang, Chunhua] Res Inst Fujian Prov, Dept Neurosurg, Fuzhou, Fujian, Peoples R China. Zhang, F (corresponding author), Fujian Med Univ, Hosp Fuzhou City Affiliated 1, Dept Neurosurg, Fuzhou 350009, Fujian, Peoples R China. fanzhangfj@163.com AN - WOS:000415958000008 AU - Yang, Y. K. AU - Wei, H. AU - Zhou, X. H. AU - Zhang, F. AU - Wang, C. H. DA - Dec DO - 10.1097/wnr.0000000000000901 J2 - Neuroreport KW - extracellular signal-regulated kinase hyperbaric oxygen neural stem cells traumatic brain injury vascular endothelial growth factor RAT MODEL VEGF DIFFERENTIATION NEUROGENESIS EXPRESSION PATHWAY Neurosciences LA - English M1 - 18 M3 - Article N1 - Web of Science (Clarivate Analytics) literature search June 18, 2021 PY - 2017 SN - 0959-4965 SP - 1232-1238 ST - Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury T2 - Neuroreport TI - Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury UR - ://WOS:000415958000008 VL - 28 ID - 932004 ER - TY - JOUR AB - BACKGROUND Hyperbaric oxygen (HBO) is a historical therapeutic option in the treatment of various types of brain damage. At present, clinical treatment of hypoxic-ischemic injury is giving priority to cognitive training. The effects of HBO on cognitive dysfunction were observed in a controlled cortical impact (CCI) rat model. MATERIAL AND METHODS Seventy male SD rats were randomly divided into control (n=10) and intervention (n=60) groups. All rats underwent baseline water maze testing 1 day before modeling, and were retested 8 weeks after modeling. The percentage of residence time during escape latency in the target quadrant and the total time were recorded. Data were analyzed by SPSS 16.0 software. P<0.05 was considered statistically significant. RESULTS After 8 weeks, no statistical difference (P>0.05) existed in spatial learning ability in the 3-day and 5-day groups when compared with baseline. The other groups were statistically different by auto-comparison (P<0.05). No statistical difference (P>0.05) in spatial memory existed in the 5-day and 1-week groups when compared with baseline, while a significant difference was noted in the other groups by self-comparison (P<0.05). No statistical difference (P>0.05) was noted in the level of expression of growth-associated protein-43 (GAP-43) and synaptophysin (Syn) in the 1-day group compared with the control group. The remaining groups and the control group were statistically different (P<0.05), while the level of expression of GAP-43 and Syn in the 5-day, 1-week, and 2-week groups was significantly different compared with that in the control group (P<0.01). CONCLUSIONS If HBO therapy was provided 5-7 days after craniocerebral trauma, there was apparent improvement in cognitive function and neuroplasticity. AD - China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Capital Medical University, Beijing, China (mainland). AN - 27450528 AU - Zhang, X. AU - Wang, X. AU - Sun, X. AU - Sun, X. AU - Zhang, Y. AU - Zhang, H. C2 - Pmc4968614 DA - Jul 23 DO - 10.12659/msm.899548 DP - NLM ET - 2016/07/28 J2 - Medical science monitor : international medical journal of experimental and clinical research KW - Animals Brain Injuries, Traumatic/*etiology/*psychology Cognition/*physiology Hyperbaric Oxygenation/*adverse effects/*methods Hypoxia-Ischemia, Brain/therapy Male Maze Learning Models, Animal Neuronal Plasticity/physiology Random Allocation Rats Rats, Sprague-Dawley LA - eng N1 - PubMed (NLM) literature search June 18, 2021 PY - 2016 SN - 1234-1010 (Print) 1234-1010 SP - 2608-15 ST - Differences in Cognitive Function of Rats with Traumatic Brain Injuries Following Hyperbaric Oxygen Therapy T2 - Med Sci Monit TI - Differences in Cognitive Function of Rats with Traumatic Brain Injuries Following Hyperbaric Oxygen Therapy VL - 22 ID - 931847 ER - TY - JOUR AB - Paroxysmal sympathetic hyperactivity (PSH) has predominantly been described after traumatic brain injury (TBI), which is associated with hyperthermia, hypertension, tachycardia, tachypnea, diaphoresis, dystonia (hypertonia or spasticity), and even motor features such as extensor/flexion posturing. Despite the pathophysiology of PSH not being completely understood, most researchers gradually agree that PSH is driven by the loss of the inhibition of excitation in the sympathetic nervous system without parasympathetic involvement. Recently, advances in the clinical and diagnostic features of PSH in TBI patients have reached a broad clinical consensus in many neurology departments. These advances should provide a more unanimous foundation for the systematic research on this clinical syndrome and its clear management. Clinically, a great deal of attention has been paid to the definition and diagnostic criteria, epidemiology and pathophysiology, symptomatic treatment, and prevention and control of secondary brain injury of PSH in TBI patients. Potential benefits of treatment for PSH may result from the three main goals: eliminating predisposing causes, mitigating excessive sympathetic outflow, and supportive therapy. However, individual pathophysiological differences, therapeutic responses and outcomes, and precision medicine approaches to PSH management are varied and inconsistent between studies. Further, many potential therapeutic drugs might suppress manifestations of PSH in the process of TBI treatment. The purpose of this review is to present current and comprehensive studies of the identification of PSH after TBI in the early stage and provide a framework for symptomatic management of TBI patients with PSH. AD - G.-M. Zhang, Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China AU - Zheng, R. Z. AU - Lei, Z. Q. AU - Yang, R. Z. AU - Huang, G. H. AU - Zhang, G. M. DB - Embase DO - 10.3389/fneur.2020.00081 KW - baclofen bromocriptine catecholamine clonazepam clonidine corticosteroid dantrolene dexmedetomidine diazepam fentanyl gabapentin labetalol lorazepam metoprolol midazolam morphine propofol propranolol adrenergic system algorithm clinical feature clinical practice disease duration disease severity Glasgow coma scale human hyperactivity hyperbaric oxygen therapy hyperhidrosis hypertension hyperthermia neurotransmission paroxysmal sympathetic hyperactivity pathophysiology physiotherapy review tachycardia tachypnea traumatic brain injury treatment outcome LA - English M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2020 SN - 1664-2295 ST - Identification and Management of Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury T2 - Frontiers in Neurology TI - Identification and Management of Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L631138029&from=export http://dx.doi.org/10.3389/fneur.2020.00081 VL - 11 ID - 931884 ER - TY - JOUR AB - OBJECTIVE: The present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury. METHODS: A prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they were enrolled as research participants and randomly assigned to control and experimental groups (n = 44 per group) using a random number table method. Both groups underwent routine treatment. Patients in the experimental group were administered hyperbaric oxygen therapy approximately 1 week after admission when their vital signs had stabilized. RESULTS: No significant intergroup differences were observed in the Glasgow Coma Scale (GCS) and U.S. National Institutes of Health Stroke Scale (NIHSS) scores before treatment. However, after oxygen treatment, compared with the control group, the experimental group showed higher GCS and lower NIHSS scores. The GCS score at admission, tracheotomy status, and first hyperbaric oxygen therapy duration were independent prognostic factors in patients with severe traumatic brain injury. CONCLUSION: Hyperbaric oxygen therapy may promote recovery of neurological function and improve the cognitive function and prognosis of patients with severe traumatic brain injury. AD - Department of Emergency, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China. Department of Neurosurgery, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China. Department of Hyperbaric Oxygen, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen , Guangdong, China. AN - 33050752 AU - Zhong, X. AU - Shan, A. AU - Xu, J. AU - Liang, J. AU - Long, Y. AU - Du, B. C2 - Pmc7710397 DA - Oct DO - 10.1177/0300060520939824 DP - NLM ET - 2020/10/15 J2 - The Journal of international medical research KW - Adult *Brain Injuries/therapy *Brain Injuries, Traumatic/therapy Female Humans *Hyperbaric Oxygenation Male Middle Aged Oxygen Prospective Studies Treatment Outcome Hyperbaric oxygen therapy brain injury cognitive function neurological function randomized trial recovery LA - eng M1 - 10 N1 - PubMed (NLM) literature search June 18, 2021 PY - 2020 SN - 0300-0605 (Print) 0300-0605 SP - 300060520939824 ST - Hyperbaric oxygen for severe traumatic brain injury: a randomized trial T2 - J Int Med Res TI - Hyperbaric oxygen for severe traumatic brain injury: a randomized trial VL - 48 ID - 931837 ER - TY - JOUR AB - Although hyperbaric oxygen (HBO) therapy can promote the recovery of neural function in patients who have suffered traumatic brain injury (TBI), the underlying mechanism is unclear. We hypothesized that hyperbaric oxygen treatment plays a neuroprotective role in TBI by increasing regional transcranial oxygen saturation (rSO2) and oxygen partial pressure (PaO2). To test this idea, we compared two groups: a control group with 20 healthy people and a treatment group with 40 TBI patients. The 40 patients were given 100% oxygen of HBO for 90 minutes. Changes in rSO2 were measured. The controls were also examined for rSO2 and PaO2, but received no treatment. rSO2 levels in the patients did not differ significantly after treatment, but levels before and after treatment were significantly lower than those in the control group. PaO2 levels were significantly decreased after the 30-minute HBO treatment. Our findings suggest that there is a disorder of oxygen metabolism in patients with sub-acute TBI. HBO does not immediately affect cerebral oxygen metabolism, and the underlying mechanism still needs to be studied in depth. AD - L.-J. Liu, Department of Emergency and Intensive Care Unit, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China AU - Zhou, B. C. AU - Liu, L. J. AU - Liu, B. DB - Embase DO - 10.4103/1673-5374.191218 KW - adult article blood gas analysis controlled study female heart muscle oxygen consumption human hyperbaric oxygen therapy male near infrared spectroscopy nerve regeneration neuroprotection observational study oxygen saturation partial pressure prospective study traumatic brain injury LA - English M1 - 9 M3 - Article N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2016 SN - 1876-7958 1673-5374 SP - 1445-1449 ST - Neuroprotection of hyperbaric oxygen therapy in sub-acute traumatic brain injury: Not by immediately improving cerebral oxygen saturation and oxygen partial pressure T2 - Neural Regeneration Research TI - Neuroprotection of hyperbaric oxygen therapy in sub-acute traumatic brain injury: Not by immediately improving cerebral oxygen saturation and oxygen partial pressure UR - https://www.embase.com/search/results?subaction=viewrecord&id=L613238904&from=export http://dx.doi.org/10.4103/1673-5374.191218 VL - 11 ID - 931930 ER - TY - JOUR AB - Traumatic brain injury (TBI) is an important cause of human mortality and morbidity, which can induce serious neurological damage. At present, clinical treatments for neurological dysfunction after TBI include hyperbaric oxygen, brain stimulation and behavioral therapy, but the therapeutic effect is not satisfactory. Recent studies have found that exogenous stem cells can migrate to damaged brain tissue, then participate in the repair of damaged brain tissue by further differentiation to replace damaged cells, while releasing anti-inflammatory factors and growth factors, thereby significantly improving neurological function. This article will mainly review the effects, deficiencies and related mechanisms of different types of stem cells in TBI. AD - Y. Deng, Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China AU - Zhou, Y. AU - Shao, A. AU - Xu, W. AU - Wu, H. AU - Deng, Y. DB - Embase DO - 10.3389/fncel.2019.00301 KW - brain derived neurotrophic factor hypoxia inducible factor 1alpha immunoglobulin enhancer binding protein macrophage inflammatory protein monocyte chemotactic protein transforming growth factor tumor necrosis factor angiogenesis behavior therapy brain depth stimulation brain tissue brain water carcinogenicity cell differentiation endothelial progenitor cell follow up genetic transfection head injury human hyperbaric oxygen therapy immunomodulation induced pluripotent stem cell mesenchymal stem cell minimal brain dysfunction mRNA expression level multipotent stem cell National Institutes of Health Stroke Scale nervous system development nervous system inflammation neural stem cell nonhuman pathophysiology phase 1 clinical trial (topic) pluripotent stem cell review spinal cord injury stem cell transplantation tissue regeneration traumatic brain injury upregulation LA - English M3 - Review N1 - Embase (Elsevier) literature search June 18, 2021 PY - 2019 SN - 1662-5102 ST - Advance of Stem Cell Treatment for Traumatic Brain Injury T2 - Frontiers in Cellular Neuroscience TI - Advance of Stem Cell Treatment for Traumatic Brain Injury UR - https://www.embase.com/search/results?subaction=viewrecord&id=L629221774&from=export http://dx.doi.org/10.3389/fncel.2019.00301 VL - 13 ID - 931889 ER -