TY - JOUR AB - The efficacy and safety of single doses of 6 mg sumatriptan, self-administered subcutaneously by patients using an auto-injector, for the acute treatment of up to three successive attacks of migraine was investigated in a multicentre, open, uncontrolled study in which 178 patients were enrolled. At attack 1, there was an improvement in headache (from severe or moderate to mild or no headache) in 74% of patients at 1 h, and in 82% at 2 h. The incidence of symptoms associated with migraine was decreased after sumatriptan injection. Nausea, vomiting and photo/phonophobia were reported by 72, 54, and 85% of patients, respectively, before the injection to treat attack 1, but by only 22, 12 and 27%, respectively, 2 h after the injection. Migraine recurred within 24 h in 27% of patients, but in 89% of patients was effectively treated with a further dose of 6 mg sumatriptan. Results for attacks 2 and 3 were similar. About 40% of patients experienced at least one adverse event; most of these were mild or moderate in intensity and were transient. It is concluded that 6 mg sumatriptan, self-administered using an auto-injector, is an effective and well tolerated treatment for migraine. Sumatriptan was as effective at attack 3 as at attack 1, and there was no evidence of a change in the incidence or the nature of adverse events with successive uses of the drug. AN - 7958382 DA - Jul-Aug DO - 10.1177/030006059402200404 DP - NLM ET - 1994/07/01 IS - 4 KW - Absenteeism Adolescent Adult Aged Female Humans Male Middle Aged Migraine Disorders/*drug therapy/physiopathology Pain Measurement Self Administration Sumatriptan/*administration & dosage/adverse effects/therapeutic use LA - eng N1 - Clinical Trial Journal Article Multicenter Study Research Support, Non-U.S. Gov't England J Int Med Res. 1994 Jul-Aug;22(4):225-35. doi: 10.1177/030006059402200404. PY - 1994 SN - 0300-0605 (Print) 0300-0605 SP - 225-35 ST - An open study of self-administration of subcutaneous sumatriptan to treat successive attacks of acute migraine. Portuguese Sumatriptan Auto-injector Study Group T2 - J Int Med Res TI - An open study of self-administration of subcutaneous sumatriptan to treat successive attacks of acute migraine. Portuguese Sumatriptan Auto-injector Study Group VL - 22 ID - 3415 ER - TY - JOUR AB - These are the 39 accepted abstracts for IAYT's Symposium on Yoga Research (SYR) September 24-24, 2014 at the Kripalu Center for Yoga & Health and published in the Final Program Guide and Abstracts. AN - 25645134 DP - NLM ET - 2015/02/04 KW - Africa Yoga Project Cbsm Children Electromyography Fitness Healthy aging India Interoceptive awareness Mindfulness Mobile electroencephalography Pranayama Rehabilitation Substance use Yoga Yoga intervention adverse event anxiety aromatase inhibitor aromatase inhibitors arthralgia autism balance bilateral biochemical brain functioning breast cancer breast cancer survivors cancer cancer patients cellular senescence college students community concept mapping cytokines depression eating behavior education effectiveness end-stage renal disease exercise fatigue fear of falling function health hemodialysis intervention malondialdehyde meditation mental health military minority mood multiple sclerosis muscular fitness nationwide survey neurocognitive obesity pain management physical activity physical performance programs psychiatric qualitative quality of life refugees school schools seniors single session social work stress stress/anxiety stroke student tools for the mind total antioxidant status trauma unilateral vision loss wellbeing women workplace yoga postures yoga protocol yoga-exercise yogic breathing program LA - eng N1 - Journal Article United States Int J Yoga Therap. 2014;24:18-38. PY - 2014 SN - 1531-2054 (Print) 1531-2054 SP - 18-38 ST - Accepted scientific research works (abstracts) T2 - Int J Yoga Therap TI - Accepted scientific research works (abstracts) VL - 24 ID - 4084 ER - TY - JOUR AB - BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. METHODS: We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). FINDINGS: Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8-75·9 million [7·2%, 6·0-8·3]), 45·1 million (29·0-62·8 million [5·6%, 4·0-7·2]), 36·3 million (25·3-50·9 million [4·5%, 3·8-5·3]), 34·7 million (23·0-49·6 million [4·3%, 3·5-5·2]), and 34·1 million (23·5-46·0 million [4·2%, 3·2-5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3-3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0-11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862-11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018-19 228). INTERPRETATION: The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-to-date information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. FUNDING: Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health. AN - 28919117 C2 - PMC5605509 C6 - EMS74185 DA - Sep 16 DO - 10.1016/s0140-6736(17)32154-2 DP - NLM ET - 2017/09/19 IS - 10100 KW - Adolescent Adult Age Distribution Aged Aged, 80 and over Cause of Death/*trends Child Child, Preschool Communicable Diseases/mortality Disabled Persons/*statistics & numerical data Female Global Burden of Disease/*statistics & numerical data Global Health/statistics & numerical data Humans Incidence Infant Infant, Newborn Male Middle Aged Noncommunicable Diseases/mortality Prevalence Sex Distribution Wounds and Injuries/mortality Young Adult LA - eng N1 - 1474-547x GBD 2016 Disease and Injury Incidence and Prevalence Collaborators MC_UU_12017/13/Medical Research Council/United Kingdom MC_UP_A620_1015/Medical Research Council/United Kingdom P01 HD031921/HD/NICHD NIH HHS/United States R01 MH110163/MH/NIMH NIH HHS/United States MC_U147585827/Medical Research Council/United Kingdom U01 AI096299/AI/NIAID NIH HHS/United States U01 AG009740/AG/NIA NIH HHS/United States MC_UU_12011/2/Medical Research Council/United Kingdom P30 AG047845/AG/NIA NIH HHS/United States D43 TW009775/TW/FIC NIH HHS/United States MC_U147585819/Medical Research Council/United Kingdom 201900/Wellcome Trust/United Kingdom SPHSU13/Chief Scientist Office/United Kingdom MC_UP_A620_1014/Medical Research Council/United Kingdom R01 HD084233/HD/NICHD NIH HHS/United States R01 HD087993/HD/NICHD NIH HHS/United States SPHSU15/Chief Scientist Office/United Kingdom SCAF/15/02/Chief Scientist Office/United Kingdom HHSN271201300071C/AG/NIA NIH HHS/United States MR/K013351/1/Medical Research Council/United Kingdom MC_UU_12011/1/Medical Research Council/United Kingdom N01HC25195/HL/NHLBI NIH HHS/United States R01 AI124389/AI/NIAID NIH HHS/United States Wellcome Trust/United Kingdom UL1 TR001881/TR/NCATS NIH HHS/United States MC_UU_12017/15/Medical Research Council/United Kingdom G0400491/Medical Research Council/United Kingdom CDF-2011-04-048/Department of Health/United Kingdom P01 AG041710/AG/NIA NIH HHS/United States MC_U147585824/Medical Research Council/United Kingdom R01 AI112339/AI/NIAID NIH HHS/United States Journal Article Lancet. 2017 Sep 16;390(10100):1211-1259. doi: 10.1016/S0140-6736(17)32154-2. PY - 2017 SN - 0140-6736 (Print) 0140-6736 SP - 1211-1259 ST - Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 T2 - Lancet TI - Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 VL - 390 ID - 3961 ER - TY - JOUR AB - Background: Social isolation, loneliness and anxiety-depressive states are emerging health conditions in the elderly. Research question: To assess whether a 4-month programme of physical activity in a group improves the emotional, social and quality of life situation in a sample of subjects over 64 years old people. Methods: Multi-centre randomized clinical trial of two groups. Study population: Patients older than 64 years assigned to three primary care teams from different locations. Inclusion criteria: Submit a score <32 on the DUKE-UNC-11 social support scale, or >12 on the Beck Depression Scale, or >10 on the Generalized Anxiety Scale (GAD-7), at the start of the study. The intervention group participated in a group physical activity program for 4-months that consisted of progressively walking sessions two days a week, 60-150 minutes long depending on the physical condition of each participant. Results: Enrolled were 94 patients who met the inclusion criteria. Mean age was 74 years (SD 5.18) and 76.6% were women. No significant differences were found at the beginning of the study between the two groups in relation to the outcome of the scales evaluated. Once the intervention was completed, improvement in the quality of life and social support was detected in the intervention group (p<.05). Both groups improved the depression and anxiety clinic but the improvement in the participants of the intervention group was higher. Those with initial depression improved 8.6 points on the scale, compared to the control that improved 3.3 points, with the final average of 17.4. Those who presented initial anxiety improved 8 points (final average: 7.5 points, cut-off point for the diagnosis of anxiety 10), compared to the control that improved 5.1 points. Conclusion: The results of this study indicate that the program developed has positive effects on improving the quality of life, social support and depression and anxiety clinic. Background: Tourism represents 45% gross domestic product in Balearic Islands. Working as a hotel housekeeper (HH) has been associated with important morbidity, especially musculoskeletal, chronic pain, a significant number of sick leaves, a high consumption of medication, poor psychological well-being and worse quality of life. Research question: Explore perceptions and opinions regarding the HH's work and health problems. Estimate and evaluate HH's health determinants, the exposition to several occupational risk factors, their lifestyles and health problems and their quality of life. Methods: Design: mixed methods: (1) exploratory qualitative study (QS) including 10 semi-structured interviews and six focus groups; (2). descriptive study (DS): individual interviews and clinical medical records. Inclusion criteria: older than 18 years, had worked during the last summer season in the Balearic Islands. Analysis: QS: transcription and content analysis; DS: descriptive statistical analysis. Results: QS: Identified positive aspects of their work: timetables, relationship with co-workers, attending clients. Highlighted negative aspects: working conditions, hard physical workload, stressful duties and insufficiently rewarded. HH associated their health problems with their work; coping strategies: self-medication or visiting their general practitioner. DS: 1.043 HH included. Mean age 43.3 years, mean working years as HH 10.7 years. Mean rooms/day: 18.1 (+/- 6.5); mean beds/day: 44.6 (+/- 20.7). HH reported often pain during the last summer season: 68.2% (IC 95% 65.3-71.0) low back pain; 60.9% (IC 95% 57.8-63.8) wrist and hands; 55.3% (IC 95% 52.2-58.3) cervical. 41.6% and 35.1% self-reported regular and poor health status, respectively. Conclusion: HH perceived hard and stressful working conditions, partly justified by the number of rooms and beds made per day. They also perceived health problems related to their work. HH frequently reported pain during the last summer season. Moreover, they perceive regular or poor health status, weaker than women from the same social class do. Background: Gender-based violence (GBV) is a public health and human rights issue, being highly prevalent (12-51%), repetitive and having a severe impact on women's health, with a high sanitary and social cost. Primary care has a key role in detection and management. There is low detection and delay in diagnosis. There is a lack of preparation to recognize abuse, especially in the approach and action after detection. Greater awareness and sensitization is required. Research question: Can a brief specific training intervention in GBV imparted to primary health care professionals in their primary health centre increase knowledge, improve attitudes and skills? Methods: A cluster-randomized clinical trial was carried out in Vigo area primary health centres with at least 20 health care professionals. A basal evaluation was made through a validated inquiry (PREMIS), which they had to retake after three months. In the intervention centres, a clinical session was imparted. pResults: Out of 264 primary health care professionals, 145 participated. There was a 63.5% loss out of 145 professionals. A statistically significant difference was detected in the field of knowledge, increasing an average of two points on a scale from 0 to 5 in these aspects: how to make appropriate questions; connections between GBV and pregnancy; why do not they leave their partners; risk determination and phases of GBV. There was also a decrease in the idea that if the patient does not recognize gender violence, there is very little that can be done. No significant differences were detected in the detection and follow-up. Conclusion: Significant differences were found in the knowledge and attitude sections after performing the intervention to the professionals. The results support the implementation of continuous brief training on GBV in primary care. Background: Out-of-hours (OOH) primary care is a topic of great interest in European countries. Reasons for this are similar across borders: to guarantee continuity of care with decreasing numbers of health care workers and to guard equity in OOHcare for all patients. In OOHcare research, valid and accessible research data are needed to fill the knowledge gap. iCAREdata aims to offer valid and immediately available information from OOHcare. Research question: How feasible is it to collect, store and link data of different OOH services in Belgium and to improve data quality registration? How useful are aggregated data to inform stakeholders, to evaluate (the quality of) services in OOH care and the effects of interventions? Methods: As a first achievement, data flows, encryption and encoding were carefully designed and implemented. Solid cooperation with the federal eHealth web services as a trusted third party was crucial. Ethical approval and approval by the data protection authority was obtained. Clear agreements were established concerning access control. A strict code of conduct was agreed upon. A steering committee was established to guard the procedures. Results: First data were collected in 2015. iCAREdata now receives +/- 3000 unique patient contacts per weekend, spread over 14 general practice cooperatives, and covering about a quarter of the Flemish population. Aggregated data, directly processed, are provided weekly on . This portal site offers an overview of, among others, the latest diagnostics, drug prescriptions and workload. iCAREdata project also collects data from emergency departments in hospitals and community pharmacists and link them to evaluate further OOH primary care. Conclusion: Developing a research database on OOHcare is feasible. The iCAREdata project succeeds in an automated output every week, offering insights on the evolution of morbidity, services and effects of interventions. Careful validation and interpretation of the data is a crucial ongoing challenge. Background: More than half of decompensations of heart failure are attended in primary care setting. No score that helps to ascertain the short-term prognosis in these patients. Research question: To develop and validate a short-term score (30 days) to predict hospitalizations or death in patients attended in primary care as a consequence of decompensation of heart failure, based on variables easily measurable in primary care setting Methods: Prospective multinational cohort study including patients treated because of a heart failure decompensation in primary care setting. There were a derivation (Spain) and a validation cohort (nine European countries). Results: The derivation cohort included 561 patients, women were 56%, mean age was 82.2 (SD 8.03) years and 31.5% of patients were hospitalized or died in the first month. In the validation cohort, 238 patients were included, women were 54%, mean age was 79.0 (10.4) years and 26.9% of patients were hospitalized or died in the first month. According to the multivariate models, sex, age, hospital admission due to heart failure the previous year, and a heart rate greater than 100 beats/minute, orthopnoea, paroxysmal nocturnal dyspnoea, NYHA functional stage III or IV, saturation of oxygen lower than 90% or an increase in the dyspnoea at the consultation with the General practitioner were included in the HEFESTOS-SCORE. The multivariate model including these variables showed a good calibration (Hosmer-Lemeshow p=.35) and discrimination (AUC 0.81, 95% CI 0.77-0.85). In the validation cohort, the model presented an adequate external validation with good calibration (Hosmer-Lemeshow p=.35) and discrimination (AUC 0.74, 95% CI 0.67-0.82). Conclusion: The HEFESTOS-SCORE, based on clinical and demographical variables easily measurable in primary care is a useful tool to stratify the short-term hospitalization and mortality in patients attended because of a heart failure decompensation. Background: Despite recommendations against long-term benzodiazepine (BZD) use, they are often prescribed during months or years in primary care. Research question: To determine facilitators and barriers that explain the variation in implementation of a primary care educational and feedback intervention targeted to general practitioners (GPs) to reduce BZDs prescriptions. Methods: A hybrid type I clinical trial: qualitative data to evaluate the implementation outcomes. Three health districts of Spain: Balearic Islands, Tarragona-Reus district (Catalonia) and Arnau de Vilanova lliria district (Valencia). Forty stakeholders (GPs) participated in five focus groups; they were selected based on their effectiveness of the intervention results: high (three groups) or low (two groups) and individual interviews to two GP of low efficiency. The Consolidated Framework for Implementation Research (CFIR) was used to guide collection and analysis of qualitative data. Two researchers evaluated the qualitative data of the focus groups by the Codebook and Rating Rules of CFIR, independently. Results: Of the 31 CFIR constructs assessed, three constructs strongly distinguished between GPs with low versus high success of the intervention (intervention complexity, individual state of change, key stakeholders engaging), seven additional constructs weakly distinguished (adaptability, external policy and incentives, implementation climate, compatibility, relative priority, self-efficacy, formally appointed internal implementation leaders), 10 had insufficient data to assess and 11 were non-related to the success of the intervention. Conclusion: We identified the constructs that explain the variation in the effectiveness of the intervention; this information is relevant to redesign successful implementation strategies focused on these constructs to implement the BENZORED intervention in health services. Background: Despite recommendations against long-term benzodiazepine (BZD) use, they are often prescribed during months or years in primary care. Research question: To evaluate the effectiveness of a primary care educational and feedback intervention targeted to general practitioners (GPs) to reduce BZDs prescriptions. Methods: Design: A two-arm parallel cluster randomized clinical trial. Settings: Primary Healthcare centres from three health districts of Spain: Balearic Islands (IbSalut), Catalonia (Institut Catala de la Salut; Tarragona-Reus district) and Community of Valencia (Conselleria de Salut Universal; Arnau de Vilanova lliria district). Participants: All GPs from the health districts included were invited to participate. Ninety percent of the GPs accepted to participate. Intervention: GPs received an educational two hours workshop training about the rationale for prescribing BZDs and deprescribing strategies for long-term BZD users, audit and monthly feedback about their prescription and access to a support web page with information to help them and leaflets to give to the patients. Control group: GPs did not receive any component of the intervention. Outcomes: Defined daily dose (DDD)/1000 inhabitants/year (DHD) of BZDs prescribed by GP at 12 months. Proportion of long-term BZD users (>6 months) and in patients aged 65 or more at 12 months. Statistical analysis: Generalized mixed linear random effect models to account for clustering at the level of healthcare centre and all analyses were based on an intention to treat principle. Results: We included 749 GPs and 49 (6.5%) were lost to follow-up. Adjusted difference between groups in DHD at 12 months was -3.26 (-4.87;-1.65), p<.001. The differences in the proportion of long-term BZD users was -0.39 (-0.58;-0.19), p<.001 and in patients older than 65 was -0.87 (-1.35;-0.26), p=.004. Conclusion: An educational and feedback intervention targeted to GPs is effective to reduce BZD prescription in primary care. Background: Patients who might also go to the general practitioner (GP) frequently consult emergency departments (ED). This leads to decreased efficiency, high workload at the ED and additional costs for both government and patient. Research question: The primary outcome is the proportion of patients who enter the ED and are handled by the GP after triage. Secondary outcomes: Referral rate to the ED by the GP, proportion of patients not following the triage advice, compliance of the nurse to the triage-instructions and health insurance expenditures. Furthermore, facilitators and barriers will be studied and an incident analysis will be performed. Methods: This is a randomised controlled trial with weekends serving as clusters. Patients presenting at the ED during OOH are triaged and allocated to either ED or GP by a trained nurse using an extension to the Manchester Triage System (MTS). During control clusters, all patients remain at the ED. Data are collected using a database for OOH care (iCAREdata). Results: So far, 296 out of 2733 (11%) patients were allocated to the GP. Two-thirds (194) of these patients did go to the GP leading to a primary outcome of 7% for 14 intervention weekends. Only eight patients were referred back to the ED. Compliance of the nurse to the extended MTS was 93%, in 6% of the cases the nurse chose ED instead of GPC and in less than one percent GPC instead of ED. The nurses chose higher urgency categories and more discriminators, leading to the GP during intervention clusters. Using an automated system, these results are updated weekly, on our poster, we will show more results that are complete. Conclusion: These first results reveal a low efficiency but a high safety of the intervention. More prolonged data collection combined with a process analysis and cost efficiency study is necessary before definitive conclusions can be drawn. Background: Low back pain is a multifactorial condition with individual and societal impact. Psychosocial factors play a larger prognostic roll. Therefore, earlier multidisciplinary treatment strategy (physical, psychological and social/occupational) could be applied to search improvement in fear-avoidance beliefs with positive effect in the evolution of low back pain. Research question: Evaluate the effectiveness of a biopsychosocial multidisciplinary intervention (physiotherapy, cognitive-behavioural and pharmacological therapy) through the changes in fear-avoidance beliefs (FABs), in working population with sub-acute non-specific LBP, compared to usual clinical care at 3 and 12 months. Methods: A cluster randomised clinical trial, conducted in 39 Primary Health Care Centres (PHCC) in Barcelona. Participants between 18 and 65 years old (n = 369; control group =188, PHCC 26 and intervention group =181, PHCC 13). Control group received usual care, according to guidelines. Intervention group received usual care plus a biopsychosocial multidisciplinary intervention (sessions 10 hours/total). The main outcome was the Fear-Avoidance Beliefs questionnaire (FABQ). Other outcomes: Evolution to chronicity. Assessment at baseline, 3 and 12 months. Analysis was by intention to treat and analyst blinded. Multiple imputations. Results: Of the 369 enrolled patients with LBP, 421 (84.0%) provided data at the three months of follow-up, and 387 (77.2%) at 12 months. Mean age of study subjects at baseline was 45.1 (SD: 10.4) years-old and 61.2% were women. At baseline, there were no differences. Both groups showed a decrease in FABQ (FAB physical and FAB-work) at three months and twelve months, with a significant difference at long-term. At FAB-physical performance, there was no significant difference over the follow-up time and at FAB-Work, a substantial difference at 12 months between groups. Conclusion: A multidisciplinary biopsychosocial intervention showed a positive effect in FABs by improving fear behaviours and avoidance at work. Community participation in primary healthcare is enshrined in international policies since the 1970s and has been re-emphasised since then, most recently in the 2018 WHO Astana Declaration (). The concept comes from a social justice perspective. It emphasises that the participation of communities who experience poverty and social exclusion is essential to the development of primary health care services shaping these services and making them relevant to those with the greatest need. This is important if we are to address the well-documented Inverse Care Law. There is, however, a translational gap between policy and practice. The stability of policies for community participation in primary healthcare is patchy. The implementation of policies into conventional ways of working is patchy. Where implementation has occurred, the coverage of community participation initiatives can be patchy - not all community members are involved. The literature shows a pattern of exclusion whereby so-called 'hard to reach' groups are not adequately involved in primary healthcare decision-making. This is the case for refugees and migrants who arrive to settle and integrate into host countries in Europe. The recent WHO Strategy and Action Plan for Refugee and Migrant Health (2016; ) is a call for action to disrupt this pattern of exclusion and improve the health of refugees and migrants. Drawing on the rich tradition of participatory health research is a valuable way forward because it provides important concepts, tools and techniques for research that is more inclusive and primary care practice. This presentation will describe innovative examples of success in family practice settings from around Europe. These have brought together refugees and migrants with primary care stakeholders and enabled them to work together to introduce and sustain changes in clinical practice. This evidence can be used to guide and strengthen community participation in primary healthcare, for all. Background: Community participation is essential for effective implementation of research programmes in primary healthcare (PHC) but also appropriate interpretation of results and optimal delivery of subsequent care. Stakeholder engagement undertaken under defined and evaluated frameworks may be key for the establishment of concrete collaboration and communication between communities and other parties involved in research. This abstract aims to report on community and stakeholder engagement methodologies, plans and activities of European research projects conducted in Crete, Greece. Research question: Could a consensus be reached regarding the methods and tools for enhancing stakeholder engagement in community-oriented PHC research? Methods: Examined programmes included RESTORE (FP7), FRESH AIR (Horizon2020) and VIGOUR (Health Programme). Identified methodologies included Normalisation Process Theory, Participatory Learning and Action, Five Steps of Stakeholders' Engagement, establishment of Stakeholder Engagement Groups under the 9 C's model (commissioners, customers, collaborators, contributors, channels, commentators, consumers, champions, competitors) and Structured Democratic Dialogue. These were implemented to a range of stakeholders, including community members, patients, migrants, Roma populations, healthcare professionals and policy-makers. Qualitative research (focus groups, individual interviews) and Thematic Content Analysis were used for design and analysis of engagement activities. Results: In RESTORE, migrants and other stakeholders selected guidelines and training supporting cross-cultural communication in PHC consultations, based on their own needs and expectations. Community members, healthcare professionals and healthcare authorities were actively involved in FRESH AIR by identifying local priorities and contextual factors for designing project interventions, providing access to communities and supporting dissemination of project achievements. In VIGOUR, multidisciplinary stakeholders were brought together and formulated a joint ambition statement for the future of integrated care in Crete. Conclusion: Various stakeholder engagement methods with documented effects are currently available. Their systematic identification, appraisal, synthesis and consolidation may serve with enhancing community participation in PHC, sustaining research results and translating findings into appropriate actions. Background: Screening for prostate cancer remains controversial, implying a trade-off between benefits and harms, and a shared decision-making process has been advocated. Decision aids are evidence-based tools that improve decision quality. For limited-resource countries, translating and making cultural adaptations to high-quality decision aids is a reasonable alternative to developing new ones. Research question: We aimed to translate and culturally adapt an English language patient decision aid addressing prostate cancer screening, so that Portuguese men can use it. Methods: We followed the European Centre for Disease Prevention and Control's (ECDC) five-step, stakeholder-based approach to adapting health communication materials: (1) selection of materials and process coordinators; (2) early review; (3) translation and back translation; (4) comprehension testing with cognitive semi-structured interviews; (5) proofreading. Cognitive interviews were conducted with 15 men, ages 55-69, from the Oporto district local community to refine the decision aid after its translation. Content analysis was performed using Ligre (TM) software. Results: Five main themes are presented: informational content, information comprehension, socio-cultural appropriateness, feelings and primary message, and personal perspective concerning prostate cancer screening. For each theme, illustrative quotes extracted from men's interviews are presented. Most men found the translated version of the decision aid to be clear, comprehensive and appropriate for its target population, albeit some suggested that medical terms could be a barrier. The data collected from men's interviews allowed the researchers to clarify concepts and expand existing content. Conclusion: The final version of the decision aid can be used in the real world clinical setting and our ECDC based approach can be replicated by other workgroups to translate and culturally adapt decision aids. What are we talking about when we talk about value? In 2006, Michael Porter and Elizabeth O. Teisberg published; Redefining Health Care, Creating Value-Based Competition on Results, Harvard Business School Press. Affirming that payers and providers, including doctors and nurses, are very concerned in demonstrating that they work a lot, and very little, or nothing, in assessing what their work contributes to the health of people and communities. Michael Porter is famous in the business world for his work on competitiveness based on the value of products and services. He has introduced this concept in the provision of health services, all summarised in a phrase: Health systems should seek to obtain the maximum possible value for the health of people for every dollar they spend. However, to define the value in healthcare, the patient must be introduced into the equation, so, in Porterian terms, the value is the perception that people have about clinical effectiveness and the costs of therapeutic processes. Clinical effectiveness is measurable from epidemiology (to be readmitted to a hospital fewer times or living longer); value, on the other hand, is reflected by people's experience. We need to ask questions such as do patients with advanced diseases want to live longer, or they want to enjoy the highest quality of life possible. Depending on the response, we can develop different delivery models. What is value-based healthcare? According to NEJM Catalyst, Value-based healthcare is a healthcare delivery model in which providers, including hospitals and physicians, are paid based on patient health outcomes (). Under value-based care agreements, providers are rewarded for helping patients improve their health, reduce the effects and incidence of chronic disease, and live healthier lives in an evidence-based way. How to achieve a Value-Based Healthcare Model The following six drivers are the key to make a primary health care system a value-based healthcare model: 1. Prioritising patient-centred care. 2. From clinical pathways to care delivery value chains. 3. Promoting the right care and reducing medical overuse. 4. Turning a fragmented model into another integrated model. 5. Creating the enabling environment for healthcare transformation. 6. Fostering community health. How to develop a Value-Based Community Health Michael Marmot states that if the determinants of health are mostly social, solutions must also be social, so to improve the quality of community life, political systems require economic, housing, education, security and infrastructure programs (Am J Public Health. 2014;104:S517-S519). Nevertheless, the healthcare system must know how to adjust resources according to the social circumstances of each community and to understand how to provide a health-oriented vision of all the social programs. On the other hand, community health is an intervention model that aims to improve the health of a defined community that should operate from primary care services to adjust their actions to the social reality of each territory. Background: Geriatric care needs to be increased with growing elderly populations. The Borgholm jurisdiction in the Baltic Island of oland (Kalmar region) has an older than average senior population and had difficulties recruiting primary care physicians (PCPs) resulting in high elderly hospital care consumption. Research question: Could a new model of geriatric care be able to decrease the hospital care needs of Borgholm as compared to the rest of Kalmar region? Methods: A new model of care was developed in Borgholm 2016-2017 where the PCP list was limited to 1000 patients, daily slots for PCP home care visits could be booked by community nurses or ambulance nurses and PCPs had daily anticipatory care planning contacts with Kalmar hospital staff. Results: Between 2014 and 2018, Borgholm home care patients >75 years old increased by 70% vs. a 2% decrease for the rest of Kalmar region. Similarly, Kalmar emergency department visits decreased by 19% in Borgholm vs. 9% increase for the rest of Kalmar. Also, Kalmar hospital care episodes decreased 7% in Borgholm vs. 13% increase for the rest of Kalmar; Kalmar hospital outpatient visits decreased 8% in Borgholm vs. 21% increase for the rest of Kalmar; total care consumption for >75 years old decreased 4% in Borgholm vs. a 10% increase for the rest of Kalmar region. Conclusion: A new geriatric care model consisting of a comprehensive collaboration between strengthened primary care and community care, hospital care and ambulance care was associated with a reduction in total care consumption for senior citizens in a rural Swedish jurisdiction. Background: Primary health care, the general practitioner, plays a critical role for early identification and care of patients with dementia. Early diagnosis of dementia allows starting therapy and improving the quality of life of the patients. Research question: To estimate the prevalence and care of patients with dementia in North Macedonia. Methods: Forty-six general practitioners (GPs) surgeries from 20 cities in Macedonia took part in the project. All individuals age over 65 years with a diagnosis of dementia were identified from GP electronic disease registers. Results: Based on the diagnosis, 450 (3.5%) patients were identified from a total population of 12,926 over 65s. The most common dementia was Alzheimer's dementia 294 (65.3%) followed by vascular dementia 27.11%. The average age of respondents in the study was 77.5 +/- 8.2 years, with 50% patients under the age of 79 years, 65.6% were female and 68.4% were with elementary school. In the entire sample, most of the patients diagnosed with dementia 195 (43.3%) said they lived with another family member. The most common risk factor was hypertension (85.1%), followed by stroke/ transitory ischemic attacks (29.3%) and equal percentage, i.e. 26.4% of patients had high levels of cholesterol and diabetes. To 242 (53.8%) acetylcholinesterase inhibitors were prescribed (donepezil, rivastigmine, galantamine), 77 (17.1%) memantine, while 247 (54.9%) another OTC therapy. 227 (50.4%) reported that they did not receive treatment. An additional analysis of the reasons for not receiving treatment was made on this sample of patients who did not receive treatment. It was found that in the majority of these patients (more than 50%) the reason for not receiving therapy was that it was not prescribed, in 142 (62.6%). Conclusion: This is the first national representative study of dementia prevalence in North Macedonia. Those data can provide information for healthcare needs people with dementia. Background: Emotional experience for medical students during clinical internships is often ignored. Yet, its influence on professional skills is certain. Research question: 'What is the emotional experience of second and third-year medical students during their first clinical internship? How do they perceive the management of their experience by their supervisors?' Methods: A qualitative study was conducted with 12 students in their second or third year of medical training at the University of Lille, in France, between 2016 and 2019. Interviews were carried out comprehensively for a total of 17 hours. Following a grounded theory approach, the analysis terminated when data were sufficient to offer a conclusive model. Results: Emotional experience during clinical internship was rich and intense. It was most often ignored and was not taken into account in the development of professional skills. The organized management was deficient. Informal training existed: when a wilful student met a dedicated teacher. Students would have welcomed a possibility to experience intense emotions in a protective environment, and only then in an empowering environment. They expressed the same desire about early exchanges on the experiences of the internship. A modelling of the informants' emotional experiences was realized in the form of three diagrams. Conclusion: Students ask to be challenged to face patients, and then to be listened to about it. Possible interventions are trauma prevention and detection of malaise in the workplace; teaching of humanist values; providing experience and reflexivity through new pedagogical means (such as cinema, theatre, literature, writing), or relational means (such as exchange groups, companionship, solidarity commitment, immersive internships and tutoring); and training supervisors. Background: Oral anticoagulants (OAC) reduce the risk for stroke and death from all causes in patients with non-valvular atrial fibrillation (NVAF). Research question: To explore adherence rates to OAC among patients with NVAF and to compare head-to-head adherence rate of different medications in long-term chronic use. Methods: We conducted a population-based cohort study Clalit Health Services, Israel. All patients, 30 years and over, with a diagnosis of NVAF before 2016 and were treated with OAC were included. We included patients that filled at least one prescription per year in the three consecutive years 2016-2018. We analysed all prescriptions that were filled for the medications from 1 January 2017 to 31 December 2017. We considered purchasing of at least nine monthly prescriptions during 2017 as 'good medication adherence.' Results: Twenty-six thousand and twenty-nine patients with NVAF who were treated with OAC were identified. Ten thousand and two hundred and eighty-four (39.5%) were treated with apixaban, 6321 (24.3%) were treated with warfarin, 6290 (24.1%) were treated with rivaroxaban 3134 (12.0%) were treated with dabigatran. Rates of good medication adherence were 88.9% for rivaroxaban, 84.9% for apixaban, 83.6% for dabigatran and 55.8% for warfarin (p<.0001). Good adherence with OAC was associated with lower LDL cholesterol and glucose levels. Advanced age was associated with higher adherence rates (p<.001). SES was not associated with medication adherence. Conclusion: Adherence rates to DOAC among patients with NVAF are high and are higher than the adherence rate to warfarin. It should be taken into consideration when choosing OAC treatment for NVAF. Background: In France, cervical cancer screening by pap-smears should be conducted triennially. Screening statistics are based on the number of cytology examinations of smears reimbursed by the Health Insurance appearing in the claim databases. The percentage of screened women is lower based on these data than on declarative surveys. If surveys are overestimating the number of screened women, it is likely that claim databases underestimate it. Research question: The primary objective was to determine the underestimation of screened women in claim databases. The secondary purpose was to estimate the proportion of female patients not reachable by their GP for a cervical cancer screening in an organized screening trial. Methods: The population was the 6327 female patients aged 30-65 years of the 24 GP investigators of the PaCUDAHL-Ge trial. We compared the lists of their female patients that had no cytology of Pap test reimbursed during the three prior years, extracted from the Health Insurance claim databases in 2015 and 2018. We selected the patients appearing on both lists meaning they had not responded to the invitation of their GP to be screened in the trial. We searched in the GPs' records valid reasons not to be screened (hysterectomy, history of cervical lesion, pregnancy, other conditions making screening irrelevant) or evidence of screening. Results: The total number of 'unscreened' women in 2018 was 2731, 1737 patients appeared on both lists, 1522 could be included for analysing, 65 had been screened, 95 had hysterectomy, three had a history of cervical lesion, nine were pregnant and 10 had other conditions making screening irrelevant, 166 patients were lost to view. Conclusion: Based on GPs' records, health insurance claim databases underestimate the number of screened women by 7.6%. The percentage of patients not responding to the invitation of their GP to be screened in the PaCUDAHL-Ge trial is 24.18%. Background: Over the past decade, the amount of digital data created by humans with or without connected tools has grown exponentially. The field of primary care (PC) did not escape this digitization, nor the use of Big Data algorithms. To evaluate the results of Big Data research in PC it seemed useful to identify which algorithms are used. Research question: What are the algorithms used for Big Data research in PC research and how are they described? Methods: Systematic review of the literature according to the recommendations of the PRISMA guide. A search equation using the following MeSH terms 'big data, data mining, Algorithms, Artificial Intelligence, Machine learning, Deep Learning, Neural Networks Natural Language Processing, general practice, electronic health records, health records' has been applied to the PUBMED database. After a selection of the titles and article summaries according to the inclusion criteria, the full versions of the eligible articles were read and analysed. Referenced articles of the sources articles were added to the analysis. The algorithms described in the articles were extracted and analysed. Results: In total, 778 articles were identified, 169 were eligible for full reading and 26 articles were finally selected. The algorithms listed in the articles are poorly described. The description is usually limited to a general explanation about how the algorithm works. Seven articles gave a partial description of the algorithm; a logic diagram was given in four articles and the codes in only two. Actually, only one article fully describes the algorithm with its mathematical description, its code and its logic diagram. Conclusion: Big Data algorithms in PC are not satisfactorily described. The lack of reproducibility is not compatible with a consistent scientific approach. Researchers should provide more information about the way they extract and analyse their data to give their readers more confidence in Big Data. Background: As a collaborative project of the Family Practice Depression and Multimorbidity group of European General Practice Research Network, the Hopkins Symptom Checklist-25 (HSCL-25) scale was identified as valid, reproducible, effective and easy to use. Subsequently, it has been translated and adapted to 13 languages, including Castilian. Currently, the scale is being validated in different languages. Research question: What are the psychometric properties of the Spanish version of HSCL-25 (HSCL-25e) for depression detection in Primary Care? Methods: HSCL-25e was administered to outpatients recruited by their physicians in six health centres involved in Spanish EIRA3 study, a trial to promote healthy behaviours in people aged from 45 to 75. Patients complimented HSCL-25 themselves. Sample size was calculated with R package (pROC). Statistical analysis: responsiveness was analysed with missing data and detecting ceiling and floor effects for the items. Principal component analysis (PCA) was done to determine the dimensions of HSCL-25e. Item-total correlation, Cronbach's alpha (global and dimensions coefficient) and squared multiple correlation were carried out to calculate internal consistency. Results: Seven hundred and sixty-nine patients out of 806 complimented HSCL-25e, 738 answered to all of the items. No patterns of missing answers were found. No ceiling effects, expected floor effect in item 18. Item 17 was the most consistent one and item 24 was the lower one. All items showed positive discrimination index for both cut-off points (1.55 and 1.75). PCA indicated two factors; 13 items corresponding to depression dimension and the other 12 items corresponding to anxiety subscale. Global Cronbach's alpha was 0.92 (0.88 calculated for depression dimension and 0.84 for anxiety dimension). Conclusion: The HSCL-25e has excellent psychometric properties when applied to Primary Care population. It has two dimensions as the original version, although the items included are not exactly the same. There are more item coincidences with the French version. Background: Cardiovascular diseases (CVDs) are the first mortality cause worldwide with 17.5 million death in 2012. Spices (Scaling-up Packages of Interventions for CVD prevention in selected sites in Europe and Sub-Saharan Africa) gathered five countries around CVD primary prevention interventions, especially for populations with low access to prevention and health care system. In France, a rural area where people were more deprived and with a low settlement of general practitioners (GPs) fitted with the project. Research question: What are the barriers and the facilitators for cardiovascular primary prevention implementation from caregivers and patients' point of view of a deprived rural area? Methods: Semi-structured interviews were conducted until theoretical saturation of data. Purposive samplings of GPs, patients, patients' families, nurses and pharmacists were designed. Five interview guides explored cardiovascular prevention, cardiovascular health promotion in the setting, actors of CVD prevention, capacities for CVD prevention, patients' and healthcare professionals' representations, barriers and facilitators in implementing CVD prevention, possible solutions. Guides were adapted concurrently to the analysis. A blinded thematic analysis and a mind-mapping were achieved for each group. Results: Thirteen GPS, 11 pharmacists', 14 nurses, 12 patients' and 12 patients' family members' interviews were achieved. Professionals highlighted a disconnection between them and national prevention programs, lack of time, payment and training for CVD prevention. Countryside was either protective or aggressive regarding CVD risk balancing gardening and space against isolation and lack of structures. GPs had poor connections with the community. Patients described their recklessness and feeling of invulnerability until their CVD appeared. Families could be a barrier to CVD prevention and lifestyle change. Risky behaviours were handed down from one generation to another. Conclusion: Innovative interventions for Spices should focus on these community specificities and individual behavioural strategies in contrast with the six national plans addressing CVD in France. These plans solely concentrate on dissemination of prevention messages and knowledge, which is of little use according to this survey. AN - WOS:000517857100001 DO - 10.1080/13814788.2020.1719994 IS - 1 N1 - [Anonymous] 1751-1402 PY - 2020 SN - 1381-4788 SP - 42-50 ST - General Practice and the Community: Research on health service, quality improvements and training. Selected abstracts from the EGPRN Meeting in Vigo, Spain, 17-20 October 2019 Abstracts T2 - European Journal of General Practice TI - General Practice and the Community: Research on health service, quality improvements and training. Selected abstracts from the EGPRN Meeting in Vigo, Spain, 17-20 October 2019 Abstracts UR - ://WOS:000517857100001 VL - 26 ID - 1861 ER - TY - JOUR AB - OBJECTIVE: The overall aim of this study was to determine the ability of 2 selected clinical tests to detect or predict neck pain, mid back pain, and low back pain in a school-based cohort of Danish 11- to 15-year-olds. METHODS: A school-based 2-year prospective cohort study was conducted. Data were collected at the age of 11 to 13 (n = 1224) and 2 years later (n = 963). Spinal pain (neck pain, mid back pain, and low back pain) was assessed by an electronic survey completed during school time, and reference standard was defined as both lifetime prevalence and frequent pain as a proxy of severity. The tests included assessments of scoliosis, hypermobility, global mobility, intersegmental mobility, end range pain, and isometric endurance of back extensors. Sensitivity, specificity, negative and positive predictive values, and odds ratios were calculated for each test individually, and area under the receiver operating characteristic curve was calculated for evaluation of all tests combined. RESULTS: The sensitivity was low, and specificity was high for all tests at both baseline (age, 11-13 years) and follow-up (age, 13-15 years). When all tests were evaluated collectively in 1 model, the area under the receiver operating characteristic curve ranged from 0.60 to 0.65. None of the selected tests could predict incidence cases of neck pain, mid back pain, or low back pain. CONCLUSION: Clinical tests commonly used in spinal screening in adolescents could not detect present spinal pain or predict future spinal pain. However, some statistically significant associations between spinal pain and tests involving a pain response from the participant were found. AU - Aartun, Ellen AU - Hartvigsen, Jan AU - Hestbaek, Lise DA - 2016/02// DO - 10.1016/j.jmpt.2016.01.007 DP - PubMed IS - 2 J2 - J Manipulative Physiol Ther KW - Adolescent Back Pain Denmark Diagnosis Female Humans Male Neck Pain Pain Measurement Physical Examination Predictive Value of Tests Prospective Studies Scoliosis Screening Sensitivity and Specificity Surveys and Questionnaires LA - eng PY - 2016 SN - 1532-6586 SP - 76-87 ST - Validity of Commonly Used Clinical Tests to Diagnose and Screen for Spinal Pain in Adolescents T2 - Journal of Manipulative and Physiological Therapeutics TI - Validity of Commonly Used Clinical Tests to Diagnose and Screen for Spinal Pain in Adolescents: A School-Based Cohort Study in 1300 Danes Aged 11-15 Years UR - http://www.ncbi.nlm.nih.gov/pubmed/26896035 VL - 39 ID - 93 ER - TY - JOUR AB - BACKGROUND: The severity and course of spinal pain is poorly understood in adolescents. The study aimed to determine the prevalence and two-year incidence, as well as the course, frequency, and intensity of pain in the neck, mid back, and low back (spinal pain). METHODS: This study was a school-based prospective cohort study. All 5th and 6th grade students (11-13 years) at 14 schools in the Region of Southern Denmark were invited to participate (N=1,348). Data were collected in 2010 and again two years later, using an e-survey completed during school time. RESULTS: The lifetime prevalence of spinal pain was 86% and 89% at baseline and follow-up, respectively. A group of 13.6% (95% CI: 11.8, 15.6) at baseline and 19.5% (95% CI: 17.1, 22.0) at follow-up reported that they had pain frequently. The frequency of pain was strongly associated with the intensity of pain, i.e., the majority of the participants reported their pain as relatively infrequent and of low intensity, whereas the participants with frequent pain also experienced pain of higher intensity. The two-year incidence of spinal pain varied between 40% and 60% across the physical locations. Progression of pain from one to more locations and from infrequent to more frequent was common over the two-year period. CONCLUSIONS: Spinal pain is common at the age of 11-15 years, but some have more pain than others. The pain is likely to progress, i.e., to more locations, higher frequency, and higher pain intensity over a two-year period. AU - Aartun, Ellen AU - Hartvigsen, Jan AU - Wedderkopp, Niels AU - Hestbaek, Lise DA - 2014/05/29/ DO - 10.1186/1471-2474-15-187 DP - PubMed J2 - BMC Musculoskelet Disord KW - Adolescent Back Pain Child Cluster Analysis Cohort Studies Denmark Female Follow-Up Studies Humans Incidence Longitudinal Studies Male Neck Pain Pain Measurement Prevalence Prospective Studies School Health Services Students LA - eng PY - 2014 SN - 1471-2474 SP - 187 ST - Spinal pain in adolescents T2 - BMC musculoskeletal disorders TI - Spinal pain in adolescents: prevalence, incidence, and course: a school-based two-year prospective cohort study in 1,300 Danes aged 11-13 UR - http://www.ncbi.nlm.nih.gov/pubmed/24885549 VL - 15 ID - 86 ER - TY - JOUR AB - Background This review supersedes the original Cochrane review first published in 2008 (Huertas-Ceballos 2008). Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities. No organic cause for this pain can be found on physical examination or investigation for the majority of such children. Althoughmany children aremanaged by reassurance and simplemeasures, a large range of psychosocial interventions involving cognitive and behavioural components have been recommended. Objectives To determine the effectiveness of psychosocial interventions for reducing pain in school-aged children with RAP. Search methods In June 2016 we searched CENTRAL, MEDLINE, Embase, eight other databases, and two trials registers. We also searched the references of identified studies and relevant reviews. Selection criteria Randomised controlled trials comparing psychosocial therapies with usual care, active control, or wait-list control for children and adolescents (aged 5 to 18 years) with RAP or an abdominal pain-related functional gastrointestinal disorder defined by the Rome III criteria were eligible for inclusion. Data collection and analysis We used standard methodological procedures expected by Cochrane. Five review authors independently selected studies, assessed them for risk of bias, and extracted relevant data. We also assessed the quality of the evidence using the GRADE approach. Main results This review includes 18 randomised controlled trials (14 new to this version), reported in 26 papers, involving 928 children and adolescents with RAP between the ages of 6 and 18 years. The interventions were classified into four types of psychosocial therapy: cognitive behavioural therapy (CBT), hypnotherapy (including guided imagery), yoga, and written self-disclosure. The studies were carried out in the USA, Australia, Canada, the Netherlands, Germany, and Brazil. The majority of the studies were small and short term; only two studies included more than 100 participants, and only five studies had follow-up assessments beyond six months. Small sample sizes and the degree of assessed risk of performance and detection bias in many studies led to the overall quality of the evidence being rated as low to very low for all outcomes. For CBT compared to control, we found evidence of treatment success postintervention (odds ratio (OR) 5.67, 95% confidence interval (CI) 1.18 to 27.32; Z = 2.16; P = 0.03; 4 studies; 175 children; very low-quality evidence), but no evidence of treatment success at medium-term follow-up (OR 3.08, 95% CI 0.93 to 10.16; Z = 1.85; P = 0.06; 3 studies; 139 children; low-quality evidence) or longterm follow-up (OR 1.29, 95% CI 0.50 to 3.33; Z = 0.53; P = 0.60; 2 studies; 120 children; low-quality evidence). We found no evidence of effects of intervention on pain intensity scores measured postintervention (standardised mean difference (SMD) -0.33, 95% CI -0.74 to 0.08; 7 studies; 405 children; low-quality evidence), or at medium-term follow-up (SMD -0.32, 95% CI -0.85 to 0.20; 4 studies; 301 children; low-quality evidence). For hypnotherapy (including studies of guided imagery) compared to control, we found evidence of greater treatment success postintervention (OR 6.78, 95% CI 2.41 to 19.07; Z = 3.63; P = 0.0003; 4 studies; 146 children; low-quality evidence) as well as reductions in pain intensity (SMD -1.01, 95% CI -1.41 to -0.61; Z = 4.97; P < 0.00001; 4 studies; 146 children; low-quality evidence) and pain frequency (SMD -1.28, 95% CI -1.84 to -0.72; Z = 4.48; P < 0.00001; 4 studies; 146 children; low-quality evidence). The only study of long-term effect reported continued benefit of hypnotherapy compared to usual care after five years, with 68% reporting treatment success compared to 20% of controls (P = 0.005). For yoga therapy compared to control, we found no evidence of effectiveness on pain intensity reduction postintervention (SMD 0.31, 95% CI -0.67 to 0.05; Z = 1.69; P = 0.09; 3 studies; 122 children; low-quality evidence). The single study of written self-disclosure therapy reported no benefit for pain. There was no evidence of effect fromthe pooled analyses for any type of intervention on the secondary outcomes of school performance, social or psychological functioning, and quality of daily life. There were no adverse effects for any of the interventions reported. Authors' conclusions The data from trials to date provide some evidence for beneficial effects of CBT and hypnotherapy in reducing pain in the short term in children and adolescents presenting with RAP. There was no evidence for the effectiveness of yoga therapy or written self-disclosure therapy. There were insufficient data to explore effects of treatment by RAP subtype. Higher-quality, longer-duration trials are needed to fully investigate the effectiveness of psychosocial interventions. Identifying the active components of the interventions and establishing whether benefits are sustained in the long term are areas of priority. Future research studies would benefit from employing active control groups to help minimise potential bias from wait-list control designs and to help account for therapist and intervention time. AN - WOS:000396096100016 AU - Abbott, R. A. AU - Martin, A. E. AU - Newlove-Delgado, T. V. AU - Bethel, A. AU - Thompson-Coon, J. AU - Whear, R. AU - Logan, S. C7 - Cd010971 DO - 10.1002/14651858.CD010971.pub2 IS - 1 N1 - Abbott, Rebecca A. Martin, Alice E. Newlove-Delgado, Tamsin V. Bethel, Alison Thompson-Coon, Joanna Whear, Rebecca Logan, Stuart Coon, Jo Thompson/C-7923-2017 Coon, Jo Thompson/0000-0002-5161-0234; Logan, Stuart/0000-0002-9279-261X; Abbott, Rebecca/0000-0003-4165-4484; Whear, Rebecca/0000-0002-8379-8198 1361-6137 PY - 2017 SN - 1469-493X ST - Psychosocial interventions for recurrent abdominal pain in childhood T2 - Cochrane Database of Systematic Reviews TI - Psychosocial interventions for recurrent abdominal pain in childhood UR - ://WOS:000396096100016 ID - 2113 ER - TY - JOUR AB - Secondary school Saudi students participated in a questionnaire about stomatognathic dysfunction symptoms. The adolescents were interviewed about general health, peripheral joint disease, chewing function, oral parafunctions, and symptoms of dysfunction. Thirty-two per cent of participants had at least one dysfunction symptom. Pain on opening was the most common (35.7%), followed by headache (33.6%), and joint sounds (32.2%). Symptoms increased with decline in general health, particularly the health of peripheral joints. Chewing functions were not impaired. Tooth loss did not affect dysfunction symptoms in adolescents, whilst a weak relation was evident between oral parafunctions and symptoms of mandibular dysfunction. AD - College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia. AN - 8933381 AU - Abdel-Hakim, A. M. AU - Alsalem, A. AU - Khan, N. DA - Oct DO - 10.1046/j.1365-2842.1996.d01-181.x DP - NLM ET - 1996/10/01 IS - 10 KW - Adolescent Adult Facial Pain/epidemiology Female Habits Headache/epidemiology Health Status Humans Male Mastication Prevalence Range of Motion, Articular Saudi Arabia/epidemiology Temporomandibular Joint Dysfunction Syndrome/*epidemiology Tooth Loss/epidemiology LA - eng N1 - Abdel-Hakim, A M Alsalem, A Khan, N Journal Article England J Oral Rehabil. 1996 Oct;23(10):655-61. doi: 10.1046/j.1365-2842.1996.d01-181.x. PY - 1996 SN - 0305-182X (Print) 0305-182x SP - 655-61 ST - Stomatognathic dysfunctional symptoms in Saudi Arabian adolescents T2 - J Oral Rehabil TI - Stomatognathic dysfunctional symptoms in Saudi Arabian adolescents VL - 23 ID - 3710 ER - TY - JOUR AB - Management of sickle cell pain in adolescent and pediatric patients is inadequate, and the employment of proper management guidelines and practices are highly variable among different regions and populations. APPT, the multidimensional adolescent pediatric pain tool, promotes optimal pain management and introduces best practical guidelines for pain management. The goal of this study is to assess pain and pain management among young patients diagnosed with sickle cell disease (SCD) by introducing the APPT as a tool for pain management, and analyze factors contributing to pain management. Information relevant to demographic data, SCD characteristics, APPT assessment, and satisfaction of patients regarding pain management were collected using a structured questionnaire. Results showed that SCD is highly associated with gender (p = 0.022), consanguinity (p = 0.012), and number of surgeries (p = 0.013). Most patients (58.9%) indicated the involvement of more than six body areas affected during pain crisis. Severe pain was described by more than half the patients (55.6%), while moderate pain was reported by 31.1%. Most patients described their pain by sensory, affective, and temporal words. The number of painful areas, pain intensity, and use of descriptive pain words was correlated and interpreted by age, BMI, school absence, and number of surgeries. Results of this study could provide guidance to healthcare providers to improve current practices for SCD pain management in order to improve health outcomes and patients' satisfaction. AN - WOS:000482974100003 AU - Abdo, S. AU - Nuseir, K. Q. AU - Altarifi, A. A. AU - Barqawi, M. AU - Ayoub, N. M. AU - Mukkatash, T. L. C7 - 182 DA - Aug DO - 10.3390/brainsci9080182 IS - 8 N1 - Abdo, Samar Nuseir, Khawla Q. Altarifi, Ahmad A. Barqawi, Moussa Ayoub, Nehad M. Mukkatash, Tareq L. Nuseir, Khawla/X-9686-2019; Mukattash, Tareq/AAN-2732-2020 Nuseir, Khawla/0000-0002-1696-247X; , Ahmad/0000-0001-9574-8422; Mukattash, Tareq/0000-0003-0200-9845 2076-3425 PY - 2019 ST - Management of Sickle Cell Disease Pain among Adolescent and Pediatric Patients T2 - Brain Sciences TI - Management of Sickle Cell Disease Pain among Adolescent and Pediatric Patients UR - ://WOS:000482974100003 VL - 9 ID - 1892 ER - TY - JOUR AB - The aim of this study was to investigate the factors associated with school absenteeism and poor school functioning in Egyptian children and adolescents with juvenile idiopathic arthritis (JIA). We studied 52 consecutive patients of JIA with age a parts per thousand yen7 years and duration of disease a parts per thousand yen1 year. All of the patients underwent assessment of socioeconomic and demographic characteristics, disease activity (JIDAS-27), functional ability (CHAQ), depressive symptoms (CDI score), and school functioning (PedsQL (TM) 4.0). Multivariate modeling was applied to determine the factors that associated with school absenteeism and poor school functioning. A total of 69 % of the sample missed 3 weeks or more of school during past academic year. The mean percentage of missed school days was 12.5 % (equivalent to 25 absent days). A total of 46 % of the patients had poor school functioning (school functioning subscale score of HRQOL a parts per thousand yen1 SD below the mean of healthy children). In multiple regression analyses, high CHAQ scores, disease activity, and depressive symptoms were independent predictors for both of school absenteeism and of poor school functioning. However, living in rural regions was independently associated only with high school absenteeism in patients with JIA. Disease activity, functional disability, and high depressive symptoms are predictors of school absenteeism and poor school functioning. These findings underscore the critical need for treatment strategies that have the ability to better control disease activity, to minimize functional disability, and depressive symptoms. More attention should be given to JIA patients who live in rural regions. AN - WOS:000329324600004 AU - Abdul-sattar, A. AU - Abou El Magd, S. AU - Negm, M. G. DA - Jan DO - 10.1007/s00296-013-2871-4 IS - 1 N1 - Abdul-sattar, Amal Abou El Magd, Sahar Negm, Mohamed G. Sattar, Amal Bakry Abdul/H-3360-2019 1437-160x PY - 2014 SN - 0172-8172 SP - 35-42 ST - Associates of school impairment in Egyptian patients with juvenile idiopathic arthritis: Sharkia Governorate T2 - Rheumatology International TI - Associates of school impairment in Egyptian patients with juvenile idiopathic arthritis: Sharkia Governorate UR - ://WOS:000329324600004 VL - 34 ID - 2327 ER - TY - JOUR AB - The aim of this study was to identify the possible determinants of impaired health-related quality of life (HRQOL) in Egyptian children and adolescents with juvenile idiopathic arthritis (JIA). Fifty-eight consecutive patients of JIA aged from 8 to 18 years underwent assessment of socio-economic and demographic characteristics; HRQOL using Pediatric Quality of Life Inventory 4.0 Generic Core Scale, disease activity using the Juvenile Arthritis Disease Activity Score based on 27 joints (JADAS-27), functional ability using the childhood health assessment questionnaire (CHAQ), pain score on visual analog scale and psychological symptoms using the Children's Depression Inventory (CDI) score. Multivariate modeling was applied to determine the factors that associated with HRQOL impairment. A total of 55 % of the patients (32 of 58) had impaired HRQOL (<78.6). In multiple regression analyses, high CHAQ scores (OR 6.0, 95 % CI 2.0-17.5, P = 0.001), pain (OR 3.1, 95 % CI 1.9-6.3, P = 0.01), stop going to school (OR 3.9, 95 % CI 2.0-7.3, P = 0.01), low socioeconomic status (OR 2.3, 95 % CI 1.09-4.7, P = 0.04) and high psychological symptoms (OR 4.2, 95 % CI 2.0-12.6, P = 0.001) were determinants for HRQOL impairment. HRQOL impairment is a significant problem in Egyptian children and adolescents with JIA. These findings underscore the critical need for monitoring of HRQOL in these patients. More attention should be given to JIA patients who stop going to school and who has low socioeconomic status. AN - WOS:000339725500009 AU - Abdul-Sattar, A. B. AU - Elewa, E. A. AU - El-Shahawy, E. E. AU - Waly, E. H. DA - Aug DO - 10.1007/s00296-014-2950-1 IS - 8 N1 - Abdul-Sattar, Amal B. Elewa, Enass A. El-Shahawy, Eman El-Dessoky Waly, Eman H. Sattar, Amal Bakry Abdul/H-3360-2019 1437-160x PY - 2014 SN - 0172-8172 SP - 1095-1101 ST - Determinants of health-related quality of life impairment in Egyptian children and adolescents with juvenile idiopathic arthritis: Sharkia Governorate T2 - Rheumatology International TI - Determinants of health-related quality of life impairment in Egyptian children and adolescents with juvenile idiopathic arthritis: Sharkia Governorate UR - ://WOS:000339725500009 VL - 34 ID - 2296 ER - TY - JOUR AB - STUDY DESIGN: A cohort of 1848 workers, representative of all sectors of industry, who were compensated for a low back injury in 1988 but not in the previous 2 years, was followed over 24 months. OBJECTIVES: To determine the prognostic value of the physician's initial diagnosis of back problems. SUMMARY OF BACKGROUND DATA: In the absence of a standardized classification of diagnoses of back pain, this study aimed to provide an element of validity to a classification previously proposed that consists of "specific" and "nonspecific" back pain. METHODS: Medical charts were reviewed at the Quebec Worker's Compensation Board to extract the diagnosis made by the treating physicians within 7 days of the first day of absence from work. Diagnoses were categorized into "specific" (lesions of vertebrae and discs) and "nonspecific" (pain, sprains, and strains). The history of compensated work absence for low back pain in the following 24 months was obtained. RESULTS: A specific diagnosis was found in 8.9% (165) of the workers, accounting for 31.0% of the patients who accumulated 6 months or more of absence in 2 years. Increasing age and daily amount of compensation also were associated with an increased risk of chronicity. CONCLUSIONS: The physician's initial diagnosis was highly associated with the risk of chronicity. The explanation for this result is complex, involving the nature of the underlying lesion as well as the impact of the diagnosis "label" on the worker and on the physician-patient relationship. AD - Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada. AN - 7701392 AU - Abenhaim, L. AU - Rossignol, M. AU - Gobeille, D. AU - Bonvalot, Y. AU - Fines, P. AU - Scott, S. DA - Apr 1 DO - 10.1097/00007632-199504000-00010 DP - NLM ET - 1995/04/01 IS - 7 KW - Absenteeism *Accidents, Occupational Adolescent Adult *Back Injuries Back Pain/economics/*epidemiology/etiology Chronic Disease Cohort Studies Female Follow-Up Studies Humans Incidence Male Medical Records Middle Aged Prevalence Prognosis Quebec/epidemiology Time Factors *Workers' Compensation LA - eng N1 - Abenhaim, L Rossignol, M Gobeille, D Bonvalot, Y Fines, P Scott, S Journal Article Research Support, Non-U.S. Gov't United States Spine (Phila Pa 1976). 1995 Apr 1;20(7):791-5. doi: 10.1097/00007632-199504000-00010. PY - 1995 SN - 0362-2436 (Print) 0362-2436 SP - 791-5 ST - The prognostic consequences in the making of the initial medical diagnosis of work-related back injuries T2 - Spine (Phila Pa 1976) TI - The prognostic consequences in the making of the initial medical diagnosis of work-related back injuries VL - 20 ID - 3444 ER - TY - JOUR AB - OBJECTIVE: To study the clinical and epidemiological characteristics of complex regional pain syndrome (CRPS) in children. PATIENTS AND METHODS: All children and adolescents under 16 years of age with a new diagnosis of CRPS who were reported to the Scottish Paediatric Surveillance Unit were included. Patients' recruitment ran between 1 November 2011 and 31 October 2015. Information was collected on patients' demography, clinical features, investigations, management and impact of disease on child and family. The diagnosis of CRPS was made on fulfilling the clinical criteria of the International Association for the Study of Pain. RESULTS: 26 cases of CRPS were reported over 4 years, giving a minimum estimated incidence of 1.16/100 000 (95% CI 0.87 to 1.44/100 000) children 5-15 years of age. Nineteen patients were female (73%) and mean age at diagnosis was 11.9 (range 5.5-15.4 years). The median interval between onset of symptoms and diagnosis was 2 months (range 1-12). The majority of children have single site involvement, with legs been more often affected than arms and the right side is more often affected than the left. There was a clear trauma at onset of the illness in 19 children and possible nerve injury in one. All investigations were normal and several treatment modalities were used with variable success. The disease had significant impacts on the patients' education and family lives. CONCLUSIONS: The estimated incidence of CRPS is 1.2/100 000 children 5-15 years old. The diagnosis of CRPS is often delayed. CRPS has a significant impact on children and their families. AD - University of Edinburgh, Edinburgh, UK Department of Paediatrics, Forth Valley Royal Hospital, Larbert, Stirlingshire, UK. Department of Paediatrics, Forth Valley Royal Hospital, Larbert, Stirlingshire, UK. AN - 27005945 AU - Abu-Arafeh, H. AU - Abu-Arafeh, I. DA - Aug DO - 10.1136/archdischild-2015-310233 DP - NLM ET - 2016/03/24 IS - 8 KW - Absenteeism Adolescent Age Distribution Age of Onset Analgesics/therapeutic use Child Child, Preschool Complex Regional Pain Syndromes/diagnosis/*therapy Female Humans Leisure Activities Magnetic Resonance Imaging Male Nerve Block/methods Prospective Studies Quality of Life Radiography Sex Distribution Ultrasonography, Doppler *Adolescents *Causalgia *Complex Regional Pain Syndrome *Incidence *Reflex Sympathetic Dystrophy LA - eng N1 - 1468-2044 Abu-Arafeh, Hashem Abu-Arafeh, Ishaq Journal Article Observational Study England Arch Dis Child. 2016 Aug;101(8):719-23. doi: 10.1136/archdischild-2015-310233. Epub 2016 Mar 22. PY - 2016 SN - 0003-9888 SP - 719-23 ST - Complex regional pain syndrome in children: incidence and clinical characteristics T2 - Arch Dis Child TI - Complex regional pain syndrome in children: incidence and clinical characteristics VL - 101 ID - 3040 ER - TY - JOUR AB - The prevalence and clinical features of migraine headache and abdominal migraine were studied in the well defined population of Aberdeen schoolchildren. Ten per cent of all children (2165) aged 5-15 years were given a questionnaire inquiring, among other symptoms, about the history of headache and abdominal pain over the past year. A total of 1754 children (81%) responded. Children with at least two episodes of severe headache and/or severe abdominal pain, attributed by the parents either to unknown causes or to migraine, were invited to attend for clinical interview and examination. After interview, 159 children fulfilled the International Headache Society's criteria for the diagnosis of migraine and 58 children had abdominal migraine giving estimated prevalence rates of 10.6% and 4.1% respectively. Children with abdominal migraine had demographic and social characteristics similar to those of children with migraine. They also had similar patterns of associated recurrent painful conditions, trigger and relieving factors, and associated symptoms during attacks. The similarities between the two conditions are so close as to suggest that they have a common pathogenesis. AN - WOS:A1995QZ45900010 AU - Abuarafeh, I. AU - Russell, G. DA - May DO - 10.1136/adc.72.5.413 IS - 5 N1 - Abuarafeh, i russell, g Abu-Arafeh, Ishaq/H-7417-2019 Abu-Arafeh, Ishaq/0000-0003-1252-0153 PY - 1995 SN - 0003-9888 SP - 413-417 ST - PREVALENCE AND CLINICAL-FEATURES OF ABDOMINAL MIGRAINE COMPARED WITH THOSE OF MIGRAINE HEADACHE T2 - Archives of Disease in Childhood TI - PREVALENCE AND CLINICAL-FEATURES OF ABDOMINAL MIGRAINE COMPARED WITH THOSE OF MIGRAINE HEADACHE UR - ://WOS:A1995QZ45900010 VL - 72 ID - 2937 ER - TY - JOUR AB - Objectives-To determine the prevalence rates of the various causes of severe headache in school-children, with special emphasis on migraine and its impact on school attendance. Design-Population based study in two stages, comprising an initial screening questionnaire followed by clinical interviews and examination of children with symptoms and a control group of asymptomatic children matched for age and sex. Setting-67 primary and secondary schools in the city of Aberdeen. Subjects-2165 children, representing a random sample of 10% of schoolchildren in Aberdeen aged 5-15 years. Main outcome measures-(a) the prevalence of migraine (International Headache Society criteria) and of other types of headache; (b) the impact of migraine on school attendance. Results-The estimated prevalence rates of migraine and tension headache were 10.6% (95% confidence interval 9.1 to 12.3) and 0.9% (0.5 to 1.5) respectively. The estimated prevalence rates for migraine without aura and migraine with aura were 7.8% (95% confidence interval 6.5 to 9.3) and 2.8% (2.0 to 3.8) respectively. In addition, 10 children (0.7%) had headaches which, though lasting less than two hours, also fulfilled the International Headache Society criteria for migraine, 14 (0.9%) had tension headaches, and 20 (1.3%) had non-specific recurrent headache. The prevalence of migraine increased with age, with male preponderance in children under 12 and female preponderance thereafter. Children with migraine lost a mean of 7.8 school days a year due to all illnesses (2.8 days (range 0-80) due to headache) as compared with a mean of 3.7 days lost by controls. Conclusions-Migraine is a common cause of headache in children and causes significantly reduced school attendance. AN - WOS:A1994PJ28200016 AU - Abuarefeh, I. AU - Russell, G. DA - Sep DO - 10.1136/bmj.309.6957.765 IS - 6957 N1 - Abuarefeh, i russell, g Abu-Arafeh, Ishaq/H-7417-2019; Fahimifar, Sepideh/M-5303-2019 Abu-Arafeh, Ishaq/0000-0003-1252-0153; PY - 1994 SN - 0959-8138 SP - 765-769 ST - PREVALENCE OF HEADACHE AND MIGRAINE IN SCHOOLCHILDREN T2 - British Medical Journal TI - PREVALENCE OF HEADACHE AND MIGRAINE IN SCHOOLCHILDREN UR - ://WOS:A1994PJ28200016 VL - 309 ID - 2946 ER - TY - JOUR AB - Introduction: Migraine attacks associated with menstruation are generally perceived as more severe than attacks outside this period. Aim and Objective: The study aimed at determining the frequency of menstrual-related headaches among a cohort of senior secondary school girls in Abeokuta, Nigeria. We also determined its burden among these school girls. Methodology: This study was cross-sectional using a validated adolescent headache survey questionnaire. A self-administration of the instrument was done during a school visit. A headache was classified using the ICHD-II criteria. Results: Of the 183 students interviewed, 123(67.2%) had recurrent headaches. Mean age +SD, 16.18+1.55 (range 12-19). The prevalence of definite migraine was 17.5% while the prevalence of probable migraine was 6.0%. The prevalence of tension-type headache was 41.0%. Migraine was significantly menstrual-related (p=0.001, 95% CI=1.06-6.63). Median pain severity score was higher among MRH group (p=0.043). The median number of days of reduced productivity and missed social activities was significantly higher in the MRH group; p= 0.001 and p=0.03, respectively. Subjects with MRH were more incapacitated by their headaches (p= 0.003). Conclusion: Menstrually related headache is prevalent even among the adolescent and it has adversely affected their productivity and social life. Care of adolescent with headaches should be intensified. AN - WOS:000510692800001 AU - Adebayo, P. B. AU - Otubogun, F. M. AU - Akinyemi, R. O. DO - 10.2147/jpr.S207620 N1 - Adebayo, Philip B. Otubogun, Folajimi M. Akinyemi, Rufus O. Adebayo, Philip/ABE-1191-2020 Akinyemi, Rufus/0000-0001-5286-428X PY - 2020 SN - 1178-7090 SP - 143-150 ST - Menstrual-Related Headaches Among a Cohort of African Adolescent Girls T2 - Journal of Pain Research TI - Menstrual-Related Headaches Among a Cohort of African Adolescent Girls UR - ://WOS:000510692800001 VL - 13 ID - 1862 ER - TY - JOUR AB - BACKGROUND: Adolescent low back pain (ALBP) can be considered a signal or precursor of a serious organic disease or telltale sign of future incidence of low back pain in adulthood. Published articles on ALBP in Nigeria are not readily available. OBJECTIVES: The study's objectives were to investigate the prevalence of Adolescent Low Back Pain (ALBP) among secondary school students in Ibadan, Nigeria and the prevalence's association with some socio-demographic variables. METHODS: Participants were adolescent students from 15 secondary schools in Ibadan. Data was collected using a respondent-administered, validated questionnaire on low back pain in adolescents. Participants (Female: 298; Male: 273) aged 14.23 ±2.27 years (range 10-19) were recruited through multi-stage random sampling. Five hundred and seventy-one (83.97%) of the 680 copies of the questionnaire administered were returned. Data was analysed using mean, standard deviation, frequency, percentages, and Chi-square test with alpha level at 0.05. RESULT: Lifetime, twelve-month, one-month and point prevalence rates of ALBP were 58.0%, 43.8%, 25.6% and 14.7% respectively. Age at first experience of ALBP was 11.86 ± 2.36 years. Gender was not significantly associated with any rate (p ≥0.317). Age (p ≤ 0.043) and engagement in commercial activities (p ≤ 0.025) were significantly associated with all period prevalence rates while injury to the back was significantly associated with all period prevalence rates except point prevalence (p = 0.087). CONCLUSION: Adolescent low back pain is common among secondary school students in Ibadan and its prevalence is significantly associated with age and engagement in commercial activities, but not with gender. AU - Adegoke, Babatunde O. A. AU - Odole, Adesola C. AU - Adeyinka, Adebayo A. DA - 2015/06// DO - 10.4314/ahs.v15i2.16 DP - PubMed IS - 2 J2 - Afr Health Sci KW - Adolescent Age Distribution Age Factors Body Mass Index Cross-Sectional Studies Female Humans low back pain Male Nigeria Pain Measurement Prevalence Risk Factors school children Schools Sex Distribution Sex Factors Sickness Impact Profile Students Surveys and Questionnaires LA - eng PY - 2015 SN - 1729-0503 SP - 429-437 ST - Adolescent low back pain among secondary school students in Ibadan, Nigeria T2 - African Health Sciences TI - Adolescent low back pain among secondary school students in Ibadan, Nigeria UR - http://www.ncbi.nlm.nih.gov/pubmed/26124788 VL - 15 ID - 80 ER - TY - JOUR AB - INTRODUCTION: irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders (FGIDs) which has been well described in western populations especially as the commonest cause of recurrent abdominal pain The aim of this study was to document the prevalence of Irritable bowel syndrome (IBS) amongst children in western Nigeria and increase the aware ness of IBS amongst physicians who manage children with abdominal pain. METHODS: This was a cross-sectional study conducted amongst children aged 10-18 years in 8 schools located in two local government areas of Lagos state. A multistage stratified random-sampling survey was conducted using the validated Rome III criteria to assess for IBS and associated risk factors. The subtypes of IBS and associated extra-intestinal symptoms were also documented. RESULTS: The prevalence of IBS was 16.0% in the study participants and the prevalence decreased with increasing age (p=0.05). Sixty two (62.5%) of the students with recurrent abdominal pain had IBS. IBS was more prevalent in the females compared to the males (p=0.000). The significant risk factors for IBS identified were gender (p=0.000), socioeconomic status (p=0.001) and past history of gastroenteritis (p=0.011). The commonest subtype of IBS seen was the alternating subtype. CONCLUSION: IBS is prevalent in African children. Physicians who attend to children need to have a high index of suspicion for IBS in children who present with abdominal pain when there are no alarm symptoms. The need for further longitudinal studies in African children cannot be overemphasized. AD - Department of Paediatrics, College of Medicine, University of Lagos,Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria. Department of Medicine, College of Medicine, University of Lagos, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria. Department of Community Health, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria. Department of Paediatrics, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria. AN - 29255563 AU - Adeniyi, O. F. AU - Adenike Lesi, O. AU - Olatona, F. A. AU - Esezobor, C. I. AU - Ikobah, J. M. C2 - PMC5724937 DO - 10.11604/pamj.2017.28.93.11512 DP - NLM ET - 2017/12/20 KW - Abdominal Pain/*etiology Adolescent Age Factors Child Cross-Sectional Studies Female Gastroenteritis/*epidemiology Humans Irritable Bowel Syndrome/*epidemiology Male Nigeria/epidemiology Prevalence Risk Factors Sex Factors Socioeconomic Factors Irritable bowel syndrome adolescents subtypes LA - eng N1 - 1937-8688 Adeniyi, Oluwafunmilayo Funke Adenike Lesi, Olufunmilayo Olatona, Foluke Adenike Esezobor, Christoper Imokhuede Ikobah, Joanah Moses Journal Article Multicenter Study Pan Afr Med J. 2017 Sep 29;28:93. doi: 10.11604/pamj.2017.28.93.11512. eCollection 2017. PY - 2017 SP - 93 ST - Irritable bowel syndrome in adolescents in Lagos T2 - Pan Afr Med J TI - Irritable bowel syndrome in adolescents in Lagos VL - 28 ID - 3844 ER - TY - JOUR AB - Objectives. Joint hypermobility (JH) or 'ligamentous laxity' is felt to be an underlying risk factor for many types of musculoskeletal presentation in paediatrics, and joint hypermobility syndrome (JHS) describes such disorders where symptoms become chronic, often more generalized and associated with functional impairment. Clinical features are felt to have much in common with more severe disorders, including Ehlers-Danlos syndrome (EDS), osteogenesis imperfecta and Marfan syndrome, although this has not been formally studied in children. We defined the clinical characteristics of all patients with joint hypermobility-related presentations seen from 1999 to 2002 in a tertiary referral paediatric rheumatology unit. Methods. Patients were identified and recruited from paediatric rheumatology clinic and ward, and a dedicated paediatric rheumatology hypermobility clinic at Great Ormond Street Hospital. Data were collected retrospectively on the patients from the paediatric rheumatology clinics (1999-2002) and prospectively on patients seen in the hypermobility clinic (2000-2002). Specifically, historical details of developmental milestones, musculoskeletal or soft tissue diagnoses and symptoms, and significant past medical history were recorded. Examination features sought included measurements of joint and soft tissue laxity, and associated conditions such as scoliosis, dysmorphic features, cardiac murmurs and eye problems. Results. One hundred and twenty-five children (64 females) were included on whom sufficient clinical data could be identified and who had clinical problems ascribed to JH present for longer than 3 months. Sixty-four were from the paediatric rheumatology clinic and 61 from the hypermobility clinic. No differences were found in any of the measures between the two populations and results are presented in a combined fashion. Three-quarters of referrals came from paediatricians and general practitioners but in only 10% was hypermobility recognized as a possible cause of joint complaint. The average age at onset of symptoms was 6.2 yr and age at diagnosis 9.0 yr, indicating a 2- to 3-yr delay in diagnosis. The major presenting complaint was arthralgia in 74%, abnormal gait in 10%, apparent joint deformity in 10% and back pain in 6%. Mean age at first walking was 15.0 months; 48% were considered 'clumsy' and 36% as having poor coordination in early childhood. Twelve per cent had 'clicky' hips at birth and 4% actual congenital dislocatable hip. Urinary tract infections were present in 13 and 6% of the female and male cases, respectively. Thirteen and 14%, respectively, had speech and learning difficulties diagnosed. A history of recurrent joint sprains was seen in 20% and actual subluxation/dislocation of joints in 10%. Forty per cent had experienced problems with handwriting tasks, 48% had major limitations of school-based physical education activities, 67% other physical activities and 41% had missed significant periods of schooling because of symptoms. Forty-three per cent described a history of easy bruising. Examination revealed that 94% scored >= 4/9 on the Beighton scale for generalized hypermobility, with knees (92%), elbows (87%), wrists (82%), hand metacarpophalangeal joints (79%), and ankles (75%) being most frequently involved. Conclusions. JHS is poorly recognized in children with a long delay in the time to diagnosis. Although there is a referral bias towards joint symptoms, a surprisingly large proportion is associated with significant neuromuscular and motor development problems. Our patients with JHS also show many overlap features with genetic disorders such as EDS and Marfan syndrome. The delay in diagnosis results in poor control of pain and disruption of normal home life, schooling and physical activities. Knowledge of the diagnosis and simple interventions are likely to be highly effective in reducing the morbidity and cost to the health and social services. AN - WOS:000229441400008 AU - Adib, N. AU - Davies, K. AU - Grahame, R. AU - Woo, P. AU - Murray, K. J. DA - Jun DO - 10.1093/rheumatology/keh557 IS - 6 N1 - Adib, N Davies, K Grahame, R Woo, P Murray, KJ PY - 2005 SN - 1462-0324 SP - 744-750 ST - Joint hypermobility syndrome in childhood. A not so benign multisystem disorder? T2 - Rheumatology TI - Joint hypermobility syndrome in childhood. A not so benign multisystem disorder? UR - ://WOS:000229441400008 VL - 44 ID - 2763 ER - TY - JOUR AB - Temporomandibular disorders and orofacial pain (TMD/OFP) conditions are challenging to diagnose for predoctoral dental students due to the multifactorial etiology, complexity, and controversial issues surrounding these conditions. The aim of this study was to determine if patients in the clinic of one U.S. dental school reported existing signs and symptoms of TMD/OFP, whether the dental students diagnosed the condition based on the reported signs and symptoms, and if the condition was then treated. The study was based on a retrospective analysis of electronic health record data over a three-year period. The results showed that, during the study period, 21,352 patients were treated by student providers. Of those patients, 5.33% reported signs or symptoms associated with TMD/OFP; 5.99% received a TMD/OFP diagnosis; and 0.26% received at least one form of TMD/OFP treatment that had either a diagnosis or signs/symptoms of TMD/OFP. In addition, a small percentage (0.24%) of patients with no documented diagnosis received some sort of TMD/OFP-related treatment. A randomly selected sample of 90 patient charts found that no diagnoses of TMD/OFP were recorded in any of them. The results suggested that students had only marginally diagnosed the problems. Training for students including comprehensive didactic courses and clinical experiences to gain knowledge, context, and skill may be required to ensure they reach the required level of competence and prepare them to face the diagnostic challenges of TMD/OFP after graduation. AD - Dr. Adibi is Associate Professor, Department of General Practice and Dental Public Health, The University of Texas School of Dentistry at Houston; Mr. Kookal is Clinical Informatics Research Data Warehouse Systems Analyst, Technology Services and Informatics, The University of Texas School of Dentistry at Houston; Ms. Fishbeck is a senior dental student, The University of Texas School of Dentistry at Houston; Mr. Thompson is a senior dental student, The University of Texas School of Dentistry at Houston; and Dr. Walji is Professor and Associate Dean, Department of Diagnostic and Biomedical Sciences, The University of Texas School of Dentistry at Houston. shawn.adibi@uth.tmc.edu. Dr. Adibi is Associate Professor, Department of General Practice and Dental Public Health, The University of Texas School of Dentistry at Houston; Mr. Kookal is Clinical Informatics Research Data Warehouse Systems Analyst, Technology Services and Informatics, The University of Texas School of Dentistry at Houston; Ms. Fishbeck is a senior dental student, The University of Texas School of Dentistry at Houston; Mr. Thompson is a senior dental student, The University of Texas School of Dentistry at Houston; and Dr. Walji is Professor and Associate Dean, Department of Diagnostic and Biomedical Sciences, The University of Texas School of Dentistry at Houston. AN - 27934670 AU - Adibi, S. S. AU - Kookal, K. K. AU - Fishbeck, N. M. AU - Thompson, C. R. AU - Walji, M. F. DA - Dec DP - NLM ET - 2016/12/10 IS - 12 KW - Adolescent Adult Aged Aged, 80 and over *Clinical Competence *Education, Dental Education, Dental, Graduate Facial Pain/*diagnosis Humans Middle Aged Pilot Projects Temporomandibular Joint Disorders/*diagnosis Young Adult *dental education *oral pain management *orofacial pain *temporomandibular disorders LA - eng N1 - 1930-7837 Adibi, Shawn S Kookal, Krishna Kumar Fishbeck, Nichole M Thompson, Chris R Walji, Muhammad F Journal Article United States J Dent Educ. 2016 Dec;80(12):1450-1456. PY - 2016 SN - 0022-0337 SP - 1450-1456 ST - Assessment of Diagnosed Temporomandibular Disorders and Orofacial Pain Conditions by Predoctoral Dental Students: A Pilot Study T2 - J Dent Educ TI - Assessment of Diagnosed Temporomandibular Disorders and Orofacial Pain Conditions by Predoctoral Dental Students: A Pilot Study VL - 80 ID - 4080 ER - TY - JOUR AB - Background Hypnosis is defined as "as an interaction in which the hypnotist uses suggested scenarios ("suggestions") to encourage a person's focus of attention to shift towards inner experiences". Aim of the work The focus of this review is to summarize the findings of controlled outcome studies investigating the potential of clinical hypnosis in pediatric populations. We will examine the following themes: anesthesia, acute and chronic pain, chemotherapy-related distress, along with other specific medical issues. Results Hypnosis is an effective method to reduce pain and anxiety before, during and after the administration of anesthetics, during local dental treatments, invasive medical procedures and in burn children. Hypnosis can be successfully used to manage recurrent headaches, abdominal pain, irritable bowel syndrome and chemotherapy-related distress. Hypnosis has an important role in managing symptoms and improving the quality of life of children suffering from asthma and cystic fibrosis and in facilitating the treatment of insomnia in school-age children. Finally, hypnosis can be effectively used for the treatment of some habitual disorders such as nocturnal enuresis and dermatologic conditions, including atopic dermatitis and chronic eczema Conclusions Clinical hypnosis seems to be a useful, cheap and side-effects free tool to manage fear, pain and several kinds of stressful experiences in pediatric populations. Children who receive self-hypnosis trainings achieve significantly greater improvements in their physical health, quality of life, and self-esteem. AD - Milton Erickson Institute, Torino, Italy.. info@ericksoninstitute.it. AN - 24165457 AU - Adinolfi, B. AU - Gava, N. DA - Sep 1 DP - NLM ET - 2013/10/30 IS - 2 KW - Anxiety Disorders Child Humans *Hypnosis Outcome Assessment, Health Care Pain *Quality of Life Treatment Outcome LA - eng N1 - Adinolfi, Barbara Gava, Nicoletta Journal Article Review Italy Acta Biomed. 2013 Sep 1;84(2):94-7. PY - 2013 SN - 0392-4203 (Print) 0392-4203 SP - 94-7 ST - Controlled outcome studies of child clinical hypnosis T2 - Acta Biomed TI - Controlled outcome studies of child clinical hypnosis VL - 84 ID - 3780 ER - TY - JOUR AB - BACKGROUND: Sickle cell disease (SCD) is of major public health concern globally, with majority of patients living in Africa. Despite its relevance, there is a dearth of research to determine the socio-demographic distribution and psychosocial impact of SCD in Ghana. The objective of this study was to examine the socio-demographic distribution and psychosocial consequences of SCD among patients in Ghana and to assess their quality of life and coping mechanisms. METHODS: A cross-sectional research design was used that involved the completion of questionnaires on socio-demographic characteristics, quality of life, coping mechanisms, anxiety and depression. Participants were 387 male and female patients attending a sickle cell clinic in a public hospital. RESULTS: Results showed that majority of the patients were single, female, less than 39 years old and had attained secondary school level of education or less. Also, patients were more satisfied by the presence of love, friends and relatives as well as home, community and neighbourhood environment. While pains of varied nature and severity were the major reasons for attending hospital in SCD condition, going to the hospital as well as having faith in God was the most frequently reported mechanisms for coping with an unbearable SCD attacks. Results of multiple regression analysis showed that some socio-demographic and quality of life indicators had strong associations with anxiety and/or depression. CONCLUSIONS: It is recommended that a holistic intervention strategy incorporating psychosocial dimensions should be considered in the treatment and management of SCD. AD - Department of Psychology, Regent University College, Accra, Ghana. Vincent.adzika@regentghana.net. Department of Psychology, Regent University College, Accra, Ghana. Department of Epidemiology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. AN - 28143586 AU - Adzika, V. A. AU - Glozah, F. N. AU - Ayim-Aboagye, D. AU - Ahorlu, C. S. C2 - PMC5282775 DA - Jan 31 DO - 10.1186/s41043-017-0081-5 DP - NLM ET - 2017/02/02 IS - 1 KW - *Adaptation, Psychological Adolescent Adult Anemia, Sickle Cell/*psychology Anxiety/*etiology Cross-Sectional Studies Demography Depression/*etiology Ghana Hospitals, Public Humans Middle Aged *Quality of Life Residence Characteristics *Social Environment Spirituality Surveys and Questionnaires Young Adult *Anxiety *Depression *Ghana *Sickle cell disease *Socio-demographic characteristics LA - eng N1 - 2072-1315 Adzika, Vincent A Glozah, Franklin N Ayim-Aboagye, Desmond Ahorlu, Collins S K Journal Article J Health Popul Nutr. 2017 Jan 31;36(1):4. doi: 10.1186/s41043-017-0081-5. PY - 2017 SN - 1606-0997 (Print) 1606-0997 SP - 4 ST - Socio-demographic characteristics and psychosocial consequences of sickle cell disease: the case of patients in a public hospital in Ghana T2 - J Health Popul Nutr TI - Socio-demographic characteristics and psychosocial consequences of sickle cell disease: the case of patients in a public hospital in Ghana VL - 36 ID - 4030 ER - TY - JOUR AB - BACKGROUND: This study aimed to verify and compare central auditory processing (CAP) performance in migraine with and without aura patients and healthy controls. METHODS: Forty-one volunteers of both genders, aged between 18 and 40 years, diagnosed with migraine with and without aura by the criteria of "The International Classification of Headache Disorders" (ICDH-3 beta) and a control group of the same age range and with no headache history, were included. Gaps-in-noise (GIN), Duration Pattern test (DPT) and Dichotic Digits Test (DDT) tests were used to assess central auditory processing performance. RESULTS: The volunteers were divided into 3 groups: Migraine with aura (11), migraine without aura (15), and control group (15), matched by age and schooling. Subjects with aura and without aura performed significantly worse in GIN test for right ear (p = .006), for left ear (p = .005) and for DPT test (p < .001) when compared with controls without headache, however no significant differences were found in the DDT test for the right ear (p = .362) and for the left ear (p = .190). CONCLUSIONS: Subjects with migraine performed worsened in auditory gap detection, in the discrimination of short and long duration. They also presented impairment in the physiological mechanism of temporal processing, especially in temporal resolution and temporal ordering when compared with controls. Migraine could be related to an impaired central auditory processing. CLINICAL TRIAL REGISTRATION: Research Ethics Committee (CEP 0480.10) - UNIFESP. AD - Division of Investigation and Treatment of Headaches (DITH), Neurology and Neurosurgery Department, Federal University of São Paulo, UNIFESP, São Paulo, SP, Brazil. agessi.larissa@gmail.com. AN - 25380661 AU - Agessi, L. M. AU - Villa, T. R. AU - Dias, K. Z. AU - Carvalho Dde, S. AU - Pereira, L. D. C2 - PMC4232973 DA - Nov 8 DO - 10.1186/1129-2377-15-72 DP - NLM ET - 2014/11/09 IS - 1 KW - Acoustic Stimulation Adolescent Adult Auditory Perception/*physiology Case-Control Studies Dichotic Listening Tests Female Humans Male Migraine with Aura/*physiopathology Migraine without Aura/*physiopathology Young Adult LA - eng N1 - 1129-2377 Agessi, Larissa Mendonça Villa, Thaís Rodrigues Dias, Karin Ziliotto Carvalho, Deusvenir de Souza Pereira, Liliane Desgualdo Journal Article J Headache Pain. 2014 Nov 8;15(1):72. doi: 10.1186/1129-2377-15-72. PY - 2014 SN - 1129-2369 (Print) 1129-2369 SP - 72 ST - Central auditory processing and migraine: a controlled study T2 - J Headache Pain TI - Central auditory processing and migraine: a controlled study VL - 15 ID - 3680 ER - TY - JOUR AB - Children with chronic pain frequently experience impairment in the school setting, but we do not yet understand how unique these struggles are to children with primary pain conditions compared to peers with disease-related pain or those without chronic pain symptoms. The objective of this study is to examine school functioning, defined as school attendance rates, overall quality of life in the school setting, and school nurse visits among adolescents with primary pain conditions, those with juvenile idiopathic arthritis (JIA)-related pain, and healthy peers. Two hundred and sixty adolescents participated in the study, including 129 with primary pain conditions, 61 with JIA, and 70 healthy comparison adolescents. They completed self- and parent-reported measures of school function. Findings show that as a group, youth with primary pain conditions reported more school absences, lower quality of life in the school setting, and more frequent school nurse visits compared to both adolescents with JIA-related pain and healthy peers. We conclude that compared to those who experience pain specific to a disease process, adolescents with primary pain conditions may face unique challenges in the school setting and may require more support to help them succeed in school in spite of pain. AU - Agoston, Anna Monica AU - Gray, Laura S. AU - Logan, Deirdre E. DA - 2016/11/30/ DO - 10.3390/children3040039 DP - PubMed IS - 4 J2 - Children (Basel) KW - child and adolescent chronic pain school functioning LA - eng PY - 2016 SN - 2227-9067 ST - Pain in School T2 - Children (Basel, Switzerland) TI - Pain in School: Patterns of Pain-Related School Impairment among Adolescents with Primary Pain Conditions, Juvenile Idiopathic Arthritis Pain, and Pain-Free Peers UR - http://www.ncbi.nlm.nih.gov/pubmed/27916882 VL - 3 ID - 63 ER - TY - JOUR AB - Recurrent headache is common in children. Among them migraine is the most common disabling cause of primary headache. It causes serious disability in child's life and family. It causes negative impact on their quality of life. Clinical characteristic of migraine in children differ from adult. It may be shorter in duration and bifrontal or bitemporal in location in contrast to adult which is longer in duration and usually unilateral. It is less common before 3 years of age. Males are more affected before puberty. But after puberty females are predominantly affected. Intensity of pain is moderate to severe. There are some triggering factors. Positive family history usually present. Disability can be assessed by PedMIDAS scale in children and adolescents which is modified version of MIDAS scale for adult. Diagnosis of migraine usually clinical but evaluation should be done to exclude severe underlying secondary cause. Management consists of pharmacological and non pharmacological approach. Parental education, life style modification is the mainstay of management. Acute treatment consists of Acetaminophen, NSAIDs and Triptans. Among Triptans, Sumatriptan nasal spray is only found effective for children. Preventive therapy aims to decrease frequency and severity of headache. Flunarizine, Propranolol, Amitryptylline, Levetiracetam, Valproate, Topiramate are found effective in pediatric age group. Pediatrician should evaluate the child to exclude secondary cause of headache when indicated. They should have also proper knowledge and skills to manage a child having migraine to improve their quality of life and academic achievement. AD - Dr Sanjida Ahmed, Medical Officer, Institute of Pediatric Neuro-disorder and Autism (IPNA), Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh. AN - 27612914 AU - Ahmed, S. AU - Tabassum, S. AU - Rahman, S. M. AU - Akhter, S. AU - Rahman, M. M. AU - Bayes, F. AU - Roy, S. DA - Jul DP - NLM ET - 2016/09/11 IS - 3 KW - Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Child Child, Preschool Female *Headache/complications/diagnosis/drug therapy Humans Male *Migraine Disorders/complications/diagnosis/drug therapy Quality of Life Topiramate/therapeutic use LA - eng N1 - Ahmed, S Tabassum, S Rahman, S M Akhter, S Rahman, M M Bayes, F Roy, S Journal Article Review Bangladesh Mymensingh Med J. 2016 Jul;25(3):589-96. PY - 2016 SN - 1022-4742 (Print) 1022-4742 SP - 589-96 ST - Migraine in Children: A Review T2 - Mymensingh Med J TI - Migraine in Children: A Review VL - 25 ID - 2968 ER - TY - JOUR AB - Background: Neck and low back pain are significant health problems due to their high prevalence among the general population. Educational intervention commonly aims to reduce the symptoms and risk for additional problems by increasing the participant's knowledge, which in turn will alter the person's behavior. The primary aim of this study was to review randomize controlled trials (RCTs) to gain insights into the effectiveness of education for the prevention and treatment of non-specific neck and low back pain. Methods: Publications were systematically searched from 1982 to March 2015 in several databases. Relevant RCTs were retrieved and assessed for methodological quality. Meta-analysis was conducted to examine the effectiveness of education for the prevention and treatment of non-specific neck and low back pain. The overall quality of evidence was assessed using the GRADE system. Results: Thirty-six RCTs (30 high-quality studies) were identified. A total of 15 RCTs, which compared education programs to no education program, were included for further analysis. All studies included investigated the effectiveness of education with intermediate-and long-term follow-ups. The results showed that education programs were not effective in preventing and treating neck pain as well as treating low back pain. Conflicting evidence was found for the effectiveness of education on prevention of low back pain. Conclusions: Evidence suggests that education programs are not recommended in preventing or treating neck pain as well as treating low back pain, unless supplementary high-quality studies provide evidence to the contrary. (C) 2015 Elsevier Ltd. All rights reserved. AN - WOS:000373615700008 AU - Ainpradub, K. AU - Sitthipornvorakul, E. AU - Janwantanakul, P. AU - van der Beek, A. J. DA - Apr DO - 10.1016/j.math.2015.10.012 N1 - Ainpradub, Kantheera Sitthipornvorakul, Ekalak Janwantanakul, Prawit van der Beek, Allard J. Janwantanakul, Prawit/0000-0001-7799-2552 1532-2769 PY - 2016 SN - 1356-689X SP - 31-41 ST - Effect of education on non-specific neck and low back pain: A meta-analysis of randomized controlled trials T2 - Manual Therapy TI - Effect of education on non-specific neck and low back pain: A meta-analysis of randomized controlled trials UR - ://WOS:000373615700008 VL - 22 ID - 2173 ER - TY - JOUR AB - BACKGROUND: The association between the weight of school bag and Low Back Pain (LBP) amongst students remains under intense debate worldwide. This study aimed to estimate the prevalence of LBP amongst public high school students (14 to 19 years) in Kuwait and to investigate the association between LBP and the weight of school bags. METHODS: An analytical cross-sectional study using multistage cluster random sampling with probability proportional to size was conducted on a total of 950 public high school students from all governorates. Data on LBP were collected through face-to-face interviews using a structured questionnaire. A 0-10 Numeric Pain Rating Scale was used to rate the intensity of LBP. The students' height and weight in addition to the weight of their school bags were measured using appropriate weight and height scales. Logistic regression was used to investigate the association between the weight of school bags and LBP while adjusting for potential confounders. RESULTS: The estimated lifetime, 6-month, and 1-month prevalence of LBP were 70.3% (95% CI: 67.30-73.21%), 49.1% (95% CI: 45.83-52.28%), and 30.8% (95% CI: 27.81-33.78%) respectively, with significantly higher prevalence amongst females compared to males (p < 0.001). The absolute weight of school bag was not significantly associated with LBP neither in univariable nor multivariable analysis. The relative weight of school bag (as a percentage of the body weight) was significantly associated with LBP in univariable analysis but not in multivariable analysis. The perceived heaviness of school bag, however, was found to be significantly associated with LBP throughout the analysis (p < 0.001). CONCLUSION: In conclusion, LBP amongst high school students in Kuwait seems to be very common with a prevalence resembling that of high-income countries. Our data suggest that the perceived heaviness of school bag is far more important than the actual bag weight. Current recommendations about the weight of school bags, which are not supported by evidence, should be revised to take into account the students' perceived heaviness of school bag. AU - Akbar, Fatemah AU - AlBesharah, Muneera AU - Al-Baghli, Jumana AU - Bulbul, Farah AU - Mohammad, Dana AU - Qadoura, Bann AU - Al-Taiar, Abdullah DA - 2019/01/22/ DO - 10.1186/s12891-019-2398-2 DP - PubMed IS - 1 J2 - BMC Musculoskelet Disord KW - Adolescent Adolescents Cross-Sectional Studies Female Humans Kuwait Low Back pain Male Prevalence Random Allocation School bags Schools Students Weight-Bearing Young Adult LA - eng PY - 2019 SN - 1471-2474 SP - 37 ST - Prevalence of low Back pain among adolescents in relation to the weight of school bags T2 - BMC musculoskeletal disorders TI - Prevalence of low Back pain among adolescents in relation to the weight of school bags UR - http://www.ncbi.nlm.nih.gov/pubmed/30670005 VL - 20 ID - 60 ER - TY - JOUR AB - Reducing the impact of rheumatic diseases in childhood is the fundamental objective of every member of the multi-disciplinary team involved in the care of affected children and families. The means by which this objective may be achieved are broad and include the implementation of a range of non-pharmacological therapies to address the effects of rheumatic diseases on the physical development of the child. In addition, the treating team must be aware of the psychosocial impact that these diseases may have and the ways in which this may be minimized. This chapter is devoted to an examination of some of the non-pharmacological issues that arise in the management of the commonest rheumatic disease found in children, juvenile idiopathic arthritis (JIA). Aspects of physical rehabilitation, schooling, medication compliance, pain management and family dynamics are discussed, as are interventions to reduce the impact of this disease and its sequelae, utilizing, where possible, evidence-based principles from the literature. Although specific issues applicable to children with arthritis will be discussed, the broad principles of much of what follows applies to all of the rheumatic diseases in childhood. AN - WOS:000178831100002 AU - Akikusa, J. D. AU - Allen, R. C. DA - Jul DO - 10.1053/berh.2002.0232 IS - 3 N1 - Akikusa, JD Allen, RC 1521-1770 PY - 2002 SN - 1521-6942 SP - 333-345 ST - Reducing the impact of rheumatic diseases in childhood T2 - Best Practice & Research in Clinical Rheumatology TI - Reducing the impact of rheumatic diseases in childhood UR - ://WOS:000178831100002 VL - 16 ID - 2827 ER - TY - JOUR AB - We evaluated 1400 randomly selected Saudi children in grades 1 through 9 to determine the prevalence of migraine and tension-type headache. Of the 1400 distributed questionnaires, 1181 (84.3%) were completed properly and so served as the basis for analysis. There were 573 boys (48.5%) and 608 girls (51.5%). Ages ranged from 6 to 18 years. Five hundred eighty-eight children (49.8%; 272 boys and 316 girls) had recurrent headache episodes not related to febrile illness in the year preceding the survey. Eighty-four children (7.1%; 37 boys and 47 girls) had recurrent episodes of migraine, and 504 (42.7%; 232 boys and 272 girls) had recurrent episodes of nonmigraine headache. For both boys and girls, the age-specific prevalence rate for nonmigraine headache rose steadily from around 15% at aged 6 to 7 years to nearly 60% after aged 15. For migraine, there was a sharp increase in the prevalence rate (from around 2% to around 9%) at aged 10 to 11, also in both boys and girls. Age-adjusted prevalence for migraine between aged 6 and 15 was 6.2%. Due to the relatively poor sensitivity of some of the IHS criteria in children, this figure may underestimate the true magnitude of migraine in the population studied. AN - WOS:000175558800007 AU - Al Jumah, M. AU - Awada, A. AU - Al Azzam, S. DA - Apr DO - 10.1046/j.1526-4610.2002.02081.x IS - 4 N1 - Al Jumah, M Awada, A Al Azzam, S 1526-4610 PY - 2002 SN - 0017-8748 SP - 281-286 ST - Headache syndromes amongst schoolchildren in Riyadh, Saudi Arabia T2 - Headache TI - Headache syndromes amongst schoolchildren in Riyadh, Saudi Arabia UR - ://WOS:000175558800007 VL - 42 ID - 2832 ER - TY - JOUR AB - Background/Objective: Primary headaches are common in the pediatric and adolescent population and can be disabling for them and their families. We aimed to assess the prevalence and burden of primary headache disorders among children and adolescents in Kuwait. Methods: A cross-sectional community-based study included Kuwaiti population aged 6-17 years. They were randomly recruited from all six governorates of Kuwait using stratified multistage cluster sampling. The Headache-Attributed Restriction, Disability, and Social Handicap and Impaired Participation (HARDSHIP) questionnaire for children and adolescents was used to collect the data. Results: Data were collected from 3,423 subjects; 664 subjects were diagnosed as having primary headache disorders. The mean age was 12.61 +/- 2.51 years and 64.2% were females. One year prevalence of headache was 19.4%. It was significantly prevalent in females compared to males (25.2% vs. 13.8%; P < 0.001). Primary headache disorder significantly increased in age group 12-17 when compared to age group 6-11 years (25.8% vs. 10.4 %; p < 0.001). One year primary headache prevalence showed non-significant differences in both males and females in age group 6-11 years (10.1% in males vs. 10.6% in females; P < 0.79), while it was significantly higher in female vs. males (38.1% vs. 15.8%; P < 0.001) in age group 12-17 years. Migraine prevalence was 10.9% followed by tension type headache (TTH) 6.2% and chronic headache 0.9%. Medical care utilization was reported in 67% of our cohort. The majority (95%) of the patients received symptomatic drugs for headache attacks and only 7.5% used preventive medication. The students with headache lost a mean of 1.29 +/- 1.23 days of school, reported mean of 1.16 +/- 1.50 days they could not do activities they had wanted to. Their parents lost a mean of 1.01 +/- 1.02 days of work because of headaches of their children during the preceding 4 weeks of the study. Conclusions: The estimated 1 year prevalence of headache was 19.4% overall. Primary headache prevalence increased with age and it was more prevalent in female adolescents compared to males of the same age. Headache disorders in children/adolescents affect school and social activities as well as their parents work. The awareness for early diagnosis and preventive medications for headache in this age group may reduce the headache burden. AN - WOS:000477814500001 AU - Al-Hashel, J. Y. AU - Ahmed, S. F. AU - Alroughani, R. C7 - 793 DA - Jul DO - 10.3389/fneur.2019.00793 N1 - Al-Hashel, Jasem Yousef Ahmed, Samar Farouk Alroughani, Raed PY - 2019 SN - 1664-2295 ST - Prevalence and Burden of Primary Headache Disorders in Kuwaiti Children and Adolescents: A Community Based Study T2 - Frontiers in Neurology TI - Prevalence and Burden of Primary Headache Disorders in Kuwaiti Children and Adolescents: A Community Based Study UR - ://WOS:000477814500001 VL - 10 ID - 1897 ER - TY - JOUR AB - BACKGROUND: The recommended weight of schoolbags is less than 10-15% of the body weight. Heavy schoolbags may result in musculoskeletal and psychological problems among primary school children. This study was conducted to assess the weight of school bags in relation to primary school children weight, and to look for the prevalence of back pain among them in Al-Ahsa, Saudi Arabia. METHODS: A total of 2567 school children were included in this study both from rural and urban areas of Al-Ahsa, Saudi Arabia. A cross sectional survey was conducted in which a pre-tested questionnaire was used to ask about demographic profile, and symptoms of back pain. The weight of the school bags and the school children was measured. RESULTS: 1860 school children (72.46%) out of 2567 were carrying bags of weight more than 15% of their body weight. The prevalence of heavy school bags was higher among the female children as compared with the male children. Back pain was reported by 42% of the school children. CONCLUSIONS: The weight of schoolbags of Al-Ahsa primary school children were higher than the internationally acceptable standards and as a result back pain was reported by 42% of school children. The school authorities and ministry of health should further evaluate and take the necessary steps to rectify the situation. AU - Al-Saleem, Saleem Ali AU - Ali, Ayub AU - Ali, Sayed Ibrahim AU - Alshamrani, Abdulaziz Anazi AU - Almulhem, Ammar Mohammed AU - Al-Hashem, Muataz Hasan DA - 2016/02// DO - 10.4172/2161-1165.1000222 DP - PubMed IS - 1 J2 - Epidemiology (Sunnyvale) KW - Back pain School bags School children LA - eng PY - 2016 SN - 2161-1165 ST - A Study of School Bag Weight and Back Pain among Primary School Children in Al-Ahsa, Saudi Arabia T2 - Epidemiology (Sunnyvale, Calif.) TI - A Study of School Bag Weight and Back Pain among Primary School Children in Al-Ahsa, Saudi Arabia UR - http://www.ncbi.nlm.nih.gov/pubmed/27570708 VL - 6 ID - 76 ER - TY - JOUR AB - Objectives: To determine the prevalence of headache and migraine, to identify symptoms that accompany headache attack, and to determine the possible effect of headache on school attendance, among high school students. Methods: A cross-sectional, questionnaire-based study of secondary school students of the National Guard Housing in Riyadh, Kingdom of Saudi Arabia, was executed during the academic year of 2002 and 2003. A sample of 1750 students was included from 4 schools by systemic random sampling for each school. The questionnaire included demographic data. The second part includes specific questions on headache, and whether there had been headache in the year preceding the survey, type of headache, and its diagnosis according to International Headache Society (IHS) criteria. Possible effect of headache on school attendance was recorded. Results: Approximately one-third of the entire study sample had recurrent headache episodes not related to febrile illness in the year preceding the survey. Female students showed a significantly higher prevalence than males of migraine, as well as non-migraine headache, with the least prevalence among the younger students of ages 16-17 years. More than one-third of all students were absent from school due to headache. Conclusion: Recurrent headache is prevalent among the high school students, and more among female students. These prevalence rates are comparable with those reported elsewhere. Health education sessions at schools, primary care clinics, and the society in general are recommended to increase awareness for this common adolescent's neurological problem. AN - WOS:000263497800020 AU - Al-Tulaihi, B. A. AU - Al-Jumah, M. A. DA - Jan IS - 1 N1 - Al-Tulaihi, Bader A. Al-Jumah, Mohammed A. PY - 2009 SN - 0379-5284 SP - 120-124 ST - Prevalence of migraine and non-migraine headache among high school students at the National Guard Housing in Riyadh, Saudi Arabia T2 - Saudi Medical Journal TI - Prevalence of migraine and non-migraine headache among high school students at the National Guard Housing in Riyadh, Saudi Arabia UR - ://WOS:000263497800020 VL - 30 ID - 2627 ER - TY - JOUR AB - Background:The prevalence of primary headaches in the pediatric population is shaped by many factors, of which pubertal status may possibly play a substantial role. Epidemiological studies in the pediatric population in the gulf region remain scarce. Aims and objectives:To examine the impact of puberty on the prevalence of primary headache disorders among female schoolchildren in Kuwait. Methods:We conducted a cross-sectional study that included Kuwaiti primary and middle schoolgirls in randomly selected schools located in two governorates in Kuwait during the academic year 2018/2019. Prevalence of headache was assessed using the Headache-Attributed Restriction, Disability, Social Handicap and Impaired Participation (HARDSHIP) questionnaire for children and adolescents. Female students were asked about their menarchal status and whether they attained menarche before or after experiencing headaches. Results:The questionnaire was completed by 669 girls with a mean age of 11.44 +/- 2.14 years. The 1-year prevalence of migraine headache disorder among girls was 23.62%, and the lifetime prevalence of any headache was 84.9%, whereas the 1-year prevalence of primary headache disorders was 47.98%. The mean age of girls with headaches was 11.44 +/- 2.14 years. With respect to diagnostic criteria, migraine headache was the most frequently reported (23.62%), followed by tension-type headaches (20.93%), chronic headaches (2.99%), and probable medication-overuse headaches (0.45%). Postpubertal females were at significantly higher risk of having primary headaches compared to their prepubertal counterparts (64.26 vs. 34%;p< 0.0001). All types of primary headaches were more significantly prevalent among postpubertal girls compared to those who are prepubertal. Conclusion:Migraine headache is commonly reported among Kuwaiti schoolgirls. Postpubertal females are at higher risk of developing primary headaches compared to prepubertal females. Pubertal transition and female sex hormones may play a significant role in the pathophysiology of headaches, migraines in particular, and further research is therefore needed to investigate the underlying mechanisms. AN - WOS:000556931200001 AU - Alashqar, A. AU - Shuaibi, S. AU - Ahmed, S. F. AU - AlThufairi, H. AU - Owayed, S. AU - AlHamdan, F. AU - Alroughani, R. AU - Al-Hashel, J. Y. C7 - 594 DA - Jul DO - 10.3389/fneur.2020.00594 N1 - Alashqar, Abdelrahman Shuaibi, Sameera Ahmed, Samar Farouk AlThufairi, Hawraa Owayed, Shaikhah AlHamdan, Fajer Alroughani, Raed Al-Hashel, Jasem Yousef AlAshqar, Abdelrahman/ABB-2545-2020 AlAshqar, Abdelrahman/0000-0002-1283-7460 PY - 2020 SN - 1664-2295 ST - Impact of Puberty in Girls on Prevalence of Primary Headache Disorder Among Female Schoolchildren in Kuwait T2 - Frontiers in Neurology TI - Impact of Puberty in Girls on Prevalence of Primary Headache Disorder Among Female Schoolchildren in Kuwait UR - ://WOS:000556931200001 VL - 11 ID - 1808 ER - TY - JOUR AB - Purpose: To develop a conceptual model representing the impact of musculoskeletal impairments (MSIs) in the lives of children in Malawi. Method: A total of 169 children with MSIs (CMSIs), family and other community members participated in 57 interviews, focus groups and observations. An inductive approach to data analysis was used to conceptualise the impact of MSIs in children's day-to-day lives. Results: The main themes that emerged were Indignity, Exclusion, Pain and Hunger. Indignity represents various affronts to children's sense of inherent equal worth as human beings, for example when bullied by peers. Exclusion refers to CMSIs being excluded from three core daily activities: school, play and household chores. Some CMSIs experienced Pain, for example as an outcome of striving to participate. Children with severe mobility impairments were at increased risk of Hunger, having less access to food outside the home and placing a burden of care on the family that could restrict household productivity. Household Poverty was therefore included in the model, as this household impact was inseparable from the impact on CMSIs. Conclusion: It is recommended that rehabilitation interventions are planned and evaluated with consideration to their impact on Exclusion, Indignity, Pain, Hunger and Household Poverty using multi-faceted partnerships. AN - WOS:000307226400008 AU - Alavi, Y. AU - Jumbe, V. AU - Hartley, S. AU - Smith, S. AU - Lamping, D. AU - Muhit, M. AU - Masiye, F. AU - Lavy, C. DO - 10.3109/09638288.2012.662260 IS - 20 N1 - Alavi, Yasmene Jumbe, Vincent Hartley, Sally Smith, Sarah Lamping, Donna Muhit, Mohammad Masiye, Francis Lavy, Chris Jumbe, Vincent C./AAF-3280-2020; Masiye, Francis/ABI-2943-2020 PY - 2012 SN - 0963-8288 SP - 1736-1746 ST - Indignity, exclusion, pain and hunger: the impact of musculoskeletal impairments in the lives of children in Malawi T2 - Disability and Rehabilitation TI - Indignity, exclusion, pain and hunger: the impact of musculoskeletal impairments in the lives of children in Malawi UR - ://WOS:000307226400008 VL - 34 ID - 2458 ER - TY - JOUR AB - BACKGROUND: Tension-type headache and migraine are among the most prevalent chronic disorders in children/adolescents. Data on health care utilization for headache in this age group, however, are sparse. METHODS: In 1399 grammar school students (aged 12-19 years) with headache in the last six months in Germany a) the burden of disease for headache (mean intensity, mean frequency in the last three months and PedMIDAS means), b) medical care utilization defined by proportion of students consulting a physician in the last 12 months and/or taking analgetic drugs in the last three months by headache types (migraine and tension-type headache) and by burden of disease were assessed. RESULTS: Primary headache substantially impaired daily living activities in adolescents which was mainly related to migraine. Medical care utilization and drug use, however, was low (consulting a physician: 12.0 %, 95 %-CI = [10.3-13.8]; taking analgetic drugs: 29.9 %, 95 %-CI = [27.5-32.4]) - even among students with severe headache (physician consultation: <35 %; taking analgetic drugs: <63 %). Two thirds of students with any headache and 40 % of those with migraine had neither seen a physician nor used analgetic drugs because of their headache in the preceding 12 months. CONCLUSIONS: Adolescents with headache might too rarely seek professional help for treatment of headache. Health promotion in adolescents should increase awareness for evidence-based treatment options for headache. AU - Albers, Lucia AU - Straube, Andreas AU - Landgraf, Mirjam N. AU - Filippopulos, Filipp AU - Heinen, Florian AU - von Kries, Rüdiger DA - 2015 DO - 10.1186/s10194-015-0534-4 DP - PubMed J2 - J Headache Pain KW - Adolescent Adult Child Cost of Illness Female Germany Headache Humans Male Migraine Disorders Patient Acceptance of Health Care Schools Students Tension-Type Headache Young Adult LA - eng PY - 2015 SN - 1129-2377 SP - 534 ST - Migraine and tension type headache in adolescents at grammar school in Germany - burden of disease and health care utilization T2 - The Journal of Headache and Pain TI - Migraine and tension type headache in adolescents at grammar school in Germany - burden of disease and health care utilization UR - http://www.ncbi.nlm.nih.gov/pubmed/26055241 VL - 16 ID - 54 ER - TY - JOUR AB - OBJECTIVES: Pain is prevalent among youth with sickle cell disease (SCD). However, previous research has been limited by small sample sizes and lacked examinations of developmental differences in pain, which are critical to minimizing the development of chronic pain as youth transition into adulthood. The primary aim of the current study was to compare pain and pain interference across 4 developmental groups in a large sample of youth with SCD. The secondary aim was to identify risk factors for greater pain and pain interference. MATERIALS AND METHODS: Utilizing a cross-sectional study design, the expression and predictors of pain and pain interference were compared across 4 developmental stages: toddlers/preschoolers (2 to 4 y), school-aged children (5 to 7 y), preadolescents (8 to 12 y), and adolescents (13 to 18 y). Participants included 386 youth with SCD and their caregivers. RESULTS: Caregiver-reported pain and pain interference and youth-reported pain interference increased across developmental groups and plateaued approaching adolescence (multivariate analyses of variance P=0.002 for pain and P<0.001 for pain interference). Elevated fatigue, anxiety, and perceived difficulties with pain management were the most robust predictors of higher youth- and caregiver-reported pain (βs ranging from 0.15 to 0.68; P<0.001) and pain interference (βs ranging from 0.18 to 0.64; P<0.001). DISCUSSION: Disease and treatment-related variables were not associated with pain. Self-reported pain was elevated in older versus younger developmental groups and was largely linked to anxiety, fatigue, and perceptions of pain management, thus highlighting the modifiable nature of factors influencing pain among youth with SCD. AD - Departments of Psychology. Department of Psychology, Concordia University, Montréal, QC, Canada. Biostatistics. Departments of Pediatric Psychology and Pediatric Pain and Palliative Medicine, Helen DeVos Children's Hospital, Grand Rapids. Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI. Hematology, St. Jude Children's Research Hospital, Memphis, TN. Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta. Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. AN - 33093339 AU - Alberts, N. M. AU - Kang, G. AU - Li, C. AU - Richardson, P. A. AU - Hodges, J. AU - Hankins, J. S. AU - Klosky, J. L. DA - Jan DO - 10.1097/ajp.0000000000000889 DP - NLM ET - 2020/10/24 IS - 1 LA - eng N1 - 1536-5409 Alberts, Nicole M Kang, Guolian Li, Chen Richardson, Patricia A Hodges, Jason Hankins, Jane S Klosky, James L Journal Article Research Support, Non-U.S. Gov't United States Clin J Pain. 2021 Jan;37(1):43-50. doi: 10.1097/AJP.0000000000000889. PY - 2021 SN - 0749-8047 SP - 43-50 ST - Pain in Youth With Sickle Cell Disease: A Report From the Sickle Cell Clinical Research and Intervention Program T2 - Clin J Pain TI - Pain in Youth With Sickle Cell Disease: A Report From the Sickle Cell Clinical Research and Intervention Program VL - 37 ID - 4028 ER - TY - JOUR AB - BACKGROUND: Diet therapies may be recommended for pediatric functional gastrointestinal disorders (FGIDs). However, little is known about the frequency with which diet therapy is recommended in FGIDs. Our aims were to determine and contrast the frequency and types of diet recommendations provided to children with FGIDs by pediatric gastroenterologists (PGIs) versus primary care pediatricians (PCPs). METHODS: A retrospective chart review was performed using data from a large, metropolitan children's academic healthcare system to identify subjects meeting Rome IV criteria for functional abdominal pain, functional dyspepsia, irritable-bowel syndrome (IBS), and/or abdominal migraine over a period of 23 months. RESULTS: Of 1929 patient charts reviewed, 268 were included for further analyses. Of these, 186 patients (69%) were seen by a PGI and 82 (31%) by a PCP. The most common diagnosis was IBS (49% for PGIs and 71% for PCPs). Diet recommendations were provided to 115 (43%) patients (PGI group: 86 [75%] vs PCP group: 29 [25%]; P < .1). The most frequent recommendations were high fiber (PGI: 15%; PCP: 14%) and low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) diet (PGI: 12%; PCP: 4%). Of those provided with diet recommendations, only 20% (n = 23) received an educational consult by a dietitian. Provision of diet recommendations was not affected by years in practice. CONCLUSION: Despite increasing awareness of the role of diet in the treatment of childhood FGIDs, a minority of patients receive diet recommendations in tertiary care or primary care settings. When diet recommendations were given, there was great variability in the guidance provided. AD - Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, East Tennessee State University, Johnson City, Tennessee, USA. Dan L, Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, USA. Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. AN - 32017170 AU - Alfaro Cruz, L. AU - Minard, C. AU - Guffey, D. AU - Chumpitazi, B. P. AU - Shulman, R. J. C2 - PMC7398825 C6 - NIHMS1063805 DA - Nov DO - 10.1002/jpen.1771 DP - NLM ET - 2020/02/06 IS - 8 KW - Child Diet Fermentation *Gastrointestinal Diseases Humans *Irritable Bowel Syndrome Monosaccharides Oligosaccharides Retrospective Studies *FODMAPs *ibs *diet *education article to disclose. LA - eng N1 - 1941-2444 Alfaro Cruz, Ligia Orcid: 0000-0001-6583-5920 Minard, Charles Guffey, Danielle Chumpitazi, Bruno P Shulman, Robert J K23 DK101688/DK/NIDDK NIH HHS/United States R01 NR013497/NR/NINR NIH HHS/United States R03 DK117219/DK/NIDDK NIH HHS/United States P30 DK056338/DK/NIDDK NIH HHS/United States 6250-51000-043/the Daffy's Foundation, and the USDA/ARS/ P30 DK56338/the Daffy's Foundation, and the USDA/ARS/ U01 DK112194/DK/NIDDK NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't JPEN J Parenter Enteral Nutr. 2020 Nov;44(8):1525-1529. doi: 10.1002/jpen.1771. Epub 2020 Feb 4. PY - 2020 SN - 0148-6071 (Print) 0148-6071 SP - 1525-1529 ST - Does a Minority of Children With Functional Gastrointestinal Disorders Receive Formal Diet Advice? T2 - JPEN J Parenter Enteral Nutr TI - Does a Minority of Children With Functional Gastrointestinal Disorders Receive Formal Diet Advice? VL - 44 ID - 3934 ER - TY - JOUR AB - The origin of recurrent abdominal pain of ''non-organic origin'' is believed to be psychogenic in most cases. But the pathogenesis of the pain itself is unknown. To test the hypothesis that recurrent abdominal pain of non-organic origin is related to increased pain sensitivity in the myofascial elements of the abdominal wall itself, an investigation of pain pressure threshold of the abdominal wall, close to the umbilicus, was carried out. Altogether 140 children in the fourth school grade, approximately 11 years old, were tested for pressure pain threshold. Two groups were constituted: one without pain symptoms (no recurrent abdominal pain, chest pains or headache (n = 50)) and one with recurrent abdominal pain (n = 49). The pressure pain threshold differed significantly (p < 0.0001). To support the hypothesis that recurrent abdominal pain is a part phenomenon of a specific pattern of muscular tension and tenderness, the pressure pain threshold was tested in five other muscles, with significant results. AN - WOS:A1993LD67000012 AU - Alfven, G. DA - May DO - 10.1111/j.1651-2227.1993.tb12727.x IS - 5 N1 - Alfven, g PY - 1993 SN - 0803-5253 SP - 481-483 ST - THE PRESSURE PAIN THRESHOLD (PPT) OF CERTAIN MUSCLES IN CHILDREN SUFFERING FROM RECURRENT ABDOMINAL-PAIN OF NONORGANIC ORIGIN - AN ALGOMETRIC STUDY T2 - Acta Paediatrica TI - THE PRESSURE PAIN THRESHOLD (PPT) OF CERTAIN MUSCLES IN CHILDREN SUFFERING FROM RECURRENT ABDOMINAL-PAIN OF NONORGANIC ORIGIN - AN ALGOMETRIC STUDY UR - ://WOS:A1993LD67000012 VL - 82 ID - 2955 ER - TY - JOUR AB - Psychosomatic symptoms among children are believed to be commonplace. In this investigation by questionnaire, 47% of 1333 schoolchildren reported one or several symptoms, such as recurrent abdominal pain, headache, chest pains, loss of appetite and disturbances in bowel function. Coexistence of such symptoms was considerable and if a child had one of these, the probability that it would have one or more other symptoms was significantly increased. This correlation may strengthen both the suspicion that these symptoms are often psychosomatic and the idea that they have common CNS origin. There were appreciable differences in the frequency of the symptoms, between children at the more socially stable schools and schools with social problems. In the latter, the frequencies of symptoms differed between Swedish and immigrant children, which was not the case in the more socially stable schools. AN - WOS:A1993LD67000013 AU - Alfven, G. DA - May DO - 10.1111/j.1651-2227.1993.tb12728.x IS - 5 N1 - Alfven, g PY - 1993 SN - 0803-5253 SP - 484-487 ST - THE COVARIATION OF COMMON PSYCHOSOMATIC SYMPTOMS AMONG CHILDREN FROM SOCIO-ECONOMICALLY DIFFERING RESIDENTIAL AREAS - AN EPIDEMIOLOGIC-STUDY T2 - Acta Paediatrica TI - THE COVARIATION OF COMMON PSYCHOSOMATIC SYMPTOMS AMONG CHILDREN FROM SOCIO-ECONOMICALLY DIFFERING RESIDENTIAL AREAS - AN EPIDEMIOLOGIC-STUDY UR - ://WOS:A1993LD67000013 VL - 82 ID - 2956 ER - TY - JOUR AB - Psychosomatic symptoms among children are believed to be commonplace. In this investigation by questionnaire, 47% of 1333 schoolchildren reported one or several symptoms, such as recurrent abdominal pain, headache, chest pains, loss of appetite and disturbances in bowel function. Coexistence of such symptoms was considerable and if a child had one of these, the probability that it would have one or more other symptoms was significantly increased. This correlation may strengthen both the suspicion that these symptoms are often psychosomatic and the idea that they have common CNS origin. There were appreciable differences in the frequency of the symptoms, between children at the more socially stable schools and schools with social problems. In the latter, the frequencies of symptoms differed between Swedish and immigrant children, which was not the case in the more socially stable schools. AD - Department of Paediatrics, Huddinge Hospital, Sweden. AN - 8518527 AU - Alfvén, G. DA - May DO - 10.1111/j.1651-2227.1993.tb12728.x DP - NLM ET - 1993/05/01 IS - 5 KW - Abdominal Pain/complications/ethnology/*psychology Adolescent Chest Pain/complications/*psychology Child Constipation/complications/psychology Diarrhea/complications/psychology Feeding and Eating Disorders/complications/psychology Female Headache/complications/*psychology Humans Male Psychophysiologic Disorders/*epidemiology/ethnology Recurrence Socioeconomic Factors Sweden/epidemiology Urban Population LA - eng N1 - Alfvén, G Journal Article Norway Acta Paediatr. 1993 May;82(5):484-7. doi: 10.1111/j.1651-2227.1993.tb12728.x. PY - 1993 SN - 0803-5253 (Print) 0803-5253 SP - 484-7 ST - The covariation of common psychosomatic symptoms among children from socio-economically differing residential areas. An epidemiological study T2 - Acta Paediatr TI - The covariation of common psychosomatic symptoms among children from socio-economically differing residential areas. An epidemiological study VL - 82 ID - 3448 ER - TY - JOUR AB - The origin of recurrent abdominal pain of "non-organic origin" is believed to be psychogenic in most cases. But the pathogenesis of the pain itself is unknown. To test the hypothesis that recurrent abdominal pain of non-organic origin is related to increased pain sensitivity in the myofascial elements of the abdominal wall itself, an investigation of pain pressure threshold of the abdominal wall, close to the umbilicus, was carried out. Altogether 140 children in the fourth school grade, approximately 11 years old, were tested for pressure pain threshold. Two groups were constituted: one without pain symptoms (no recurrent abdominal pain, chest pains or headache (n = 50)) and one with recurrent abdominal pain (n = 49). The pressure pain threshold differed significantly (p < 0.0001). To support the hypothesis that recurrent abdominal pain is a part phenomenon of a specific pattern of muscular tension and tenderness, the pressure pain threshold was tested in five other muscles, with significant results. AD - Department of Paediatrics, Huddinge Hospital, Sweden. AN - 8518526 AU - Alfvén, G. DA - May DO - 10.1111/j.1651-2227.1993.tb12727.x DP - NLM ET - 1993/05/01 IS - 5 KW - Abdominal Pain/physiopathology/*psychology Algorithms Case-Control Studies Child Female Humans Male Muscles/*physiology/physiopathology Pain Measurement/instrumentation *Pain Threshold Pressure Psychophysiologic Disorders/*physiopathology Recurrence LA - eng N1 - Alfvén, G Journal Article Norway Acta Paediatr. 1993 May;82(5):481-3. doi: 10.1111/j.1651-2227.1993.tb12727.x. PY - 1993 SN - 0803-5253 (Print) 0803-5253 SP - 481-3 ST - The pressure pain threshold (PPT) of certain muscles in children suffering from recurrent abdominal pain of non-organic origin. An algometric study T2 - Acta Paediatr TI - The pressure pain threshold (PPT) of certain muscles in children suffering from recurrent abdominal pain of non-organic origin. An algometric study VL - 82 ID - 3559 ER - TY - JOUR AB - Aim Recurrent pain of unknown origin is a major problem in children. The aim of the present review was to examine the hypothesis of negative stress as an aetiology of recurrent pain from different aspects. Methods and Results Epidemiological studies, clinical experience and hormonal data give support for such a hypothesis. Negative stress as a tentative aetiology for recurrent pain is reviewed. Stress, muscular tension, the startle reaction and its tentative relation to pain is illuminated. Deviations of hormonal secretion supporting a stress aetiology are mentioned. The role of central sensitisation for recurrent pain is discussed. Possible aetiological implications of recurrent pain as a local symptom or a general disorder are presented. Brain changes due to stress are shortly reviewed. Stress and pain in the clinic are highlighted. The importance of biological, psychological and social factors, as well as genetic elements, is discussed. Conclusion Stress elicits neurobiological mechanisms. They may lead to many neurophysiological deviances. Increase of muscle tension and neuromuscular excitability and enhanced startle reaction may be of importance for recurring pain. The identification of stress as a primary cause of recurrent pain can have huge implications for understanding signs and treatment in clinical practice. AN - WOS:000495427200006 AU - Alfven, G. AU - Grillner, S. AU - Andersson, E. DA - Dec DO - 10.1111/apa.14884 IS - 12 N1 - Alfven, G. Grillner, S. Andersson, E. 1651-2227 PY - 2019 SN - 0803-5253 SP - 2148-2156 ST - Review of childhood pain highlights the role of negative stress T2 - Acta Paediatrica TI - Review of childhood pain highlights the role of negative stress UR - ://WOS:000495427200006 VL - 108 ID - 1869 ER - TY - JOUR AB - Objectives: To investigate the frequency of irritable bowel syndrome (IBS), and symptoms compatible with this condition among male students studying in secondary schools for boys in AlJouf province of Saudi Arabia. Methods: A cross sectional study was conducted in April 2009, AlJouf province of Saudi Arabia, involving a self administered questionnaire (translated in Arabic) based on Manning and Rome II criteria for diagnosis of IBS that was distributed to 2025 students at secondary school for boys, by convenience sampling. About 86.3% (1747) completed the questionnaire. Sample size was calculated using Epi. Info 6.4, seat calculator. Results: The prevalence of IBS was 8.9 % and 9.2 % according to Manning and Rome II criteria for diagnosis of IBS respectively in the study subjects with mean age of 17.5 +/- 3 years and range of 15-23 years. The most common symptom compatible with IBS was abdominal pain or discomfort in 37.9% of our sample, followed by feeling of incomplete rectal evacuation after defecation in 32.2% of the same sample. Recurrent abdominal pain or discomfort caused increase in rates of absence from schools in 28.2% of affected students (p<0.05). There is a statistically significant association between family size and clusters of symptoms compatible with IBS (p<0.045). Conclusion: IBS is common health problem in apparently healthy males studying in secondary schools for boys in AlJouf province of Saudi Arabia. Symptoms suggestive of this condition leading to a negative impact on their quality of life measures, and school performance.. Early diagnosis and health education of this condition are imperative. AN - WOS:000296043900016 AU - Alhazmi, A. H. DA - Nov IS - 11 N1 - Alhazmi, Ahmad Homoud PY - 2011 SN - 0030-9982 SP - 1111-1115 ST - Irritable bowel syndrome in secondary school male students in AlJouf Province, North of Saudi Arabia T2 - Journal of the Pakistan Medical Association TI - Irritable bowel syndrome in secondary school male students in AlJouf Province, North of Saudi Arabia UR - ://WOS:000296043900016 VL - 61 ID - 2473 ER - TY - JOUR AB - Introduction Chronic migraine is particularly devastating. It affects school work, extracurricular activities, and quality of life, including relationships with other family members, and can also influence the mental health of both the migraineurs and family members. According to the International Classification of Headache Disorders, 3rd edition (ICHD-3), chronic migraine is defined as 15 or more headache days per month for greater than three months, where at least on eight days per month, there are features of migraine headache. Although botulinum toxin type A (BoNTA) has been proven effective for treating chronic migraine in adults, little literature exists about its use in children. Here, we present the treatment response in children with chronic migraines treated with BoNTA at our institutions Duke and State University of New York (SUNY) Upstate. Method A retrospective analysis of 30 adolescent migraineurs who met ICHD-3 criteria for chronic migraine were treated with BoNTA injection according to the standardized adult protocol. Descriptive statistics and paired t-tests were performed. A total of 185 units of botulinum toxin were injected intramuscularly per patient, as in addition to the standard 31 sites for a total of 155 units, an additional 30 units were given in areas that were felt to provide further benefit. Results Participants (n=30) were 16.5 +/- 1.83 years old. The headaches were precipitated by trauma in seven cases. All had failed standard pharmacotherapy, including amitriptyline and topiramate. An average of 2.47 +/- 1.6 BoNTA injection cycles was performed. Migraine severity decreased significantly from 7.47 +/- 1.89 on a 10-point scale to 4.34 +/- 3.02 (p<.001). Additionally, headache frequency improved from 24.4 +/- 7.49 painful days per month to 14.8 +/- 12.52 painful days per month (p<.001). One patient developed nausea related to injections; all others tolerated it well, with no side effects. Discussion BoNTA injection was a safe and effective therapy for chronic migraine in our cohort of children recalcitrant to medical therapy. Further research with multi-centered, double-blinded, randomized, placebo-controlled trials is warranted to evaluate the long-term safety and efficacy in this population. AN - WOS:000463373500002 AU - Ali, S. S. AU - Bragin, I. AU - Rende, E. AU - Mejico, L. AU - Werner, K. E. C7 - e4343 DA - Mar DO - 10.7759/cureus.4343 IS - 3 N1 - Ali, Sameer S. Bragin, Ilya Rende, Elizabeth Mejico, Luis Werner, Klaus E. 2168-8184 PY - 2019 ST - Further Evidence that Onabotulinum ,Toxin is a Viable Treatment Option for Pediatric Chronic Migraine Patients T2 - Cureus TI - Further Evidence that Onabotulinum ,Toxin is a Viable Treatment Option for Pediatric Chronic Migraine Patients UR - ://WOS:000463373500002 VL - 11 ID - 1940 ER - TY - JOUR AB - BACKGROUND: The Pain Coping Skills Training for African Americans with OsteoaRTthritis (STAART) trial is examining the effectiveness of a culturally enhanced pain coping skills training (CST) program for African Americans with osteoarthritis (OA). This disparities-focused trial aimed to reach a population with greater symptom severity and risk factors for poor pain-related outcomes than previous studies. This paper compares characteristics of STAART participants with prior studies of CST or cognitive behavioral therapy (CBT)-informed training in pain coping strategies for OA. METHODS: A literature search identified 10 prior trials of pain CST or CBT-informed pain coping training among individuals with OA. We descriptively compared characteristics of STAART participants with other studies, in 3 domains of the National Institutes of Minority Health and Health Disparities' Research Framework: Sociocultural Environment (e.g., age, education, marital status), Biological Vulnerability and Mechanisms (e.g, pain and function, body mass index), and Health Behaviors and Coping (e.g., pain catastrophizing). Means and standard deviations (SDs) or proportions were calculated for STAART participants and extracted from published manuscripts for comparator studies. RESULTS: The mean age of STAART participants, 59 years (SD = 10.3), was lower than 9 of 10 comparator studies; the proportion of individuals with some education beyond high school, 75%, was comparable to comparator studies (61-86%); and the proportion of individuals who are married or living with a partner, 42%, was lower than comparator studies (62-66%). Comparator studies had less than about 1/3 African American participants. Mean scores on the Western Ontario and McMaster Universities Osteoarthritis Index pain and function scales were higher (worse) for STAART participants than for other studies, and mean body mass index of STAART participants, 35.2 kg/m(2) (SD = 8.2), was higher than all other studies (30-34 kg/m(2)). STAART participants' mean score on the Pain Catastrophizing scale, 19.8 (SD = 12.3), was higher (worse) than other studies reporting this measure (7-17). CONCLUSIONS: Compared with prior studies with predominantly white samples, STAART participants have worse pain and function and more risk factors for negative pain-related outcomes across several domains. Given STAART participants' high mean pain catastrophizing scores, this sample may particularly benefit from the CST intervention approach. TRIAL REGISTRATION: NCT02560922. AD - Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 3300 Thurston Bldg., CB# 7280, Chapel Hill, NC, 27599-7280, USA. kdallen@email.unc.edu. Department of Medicine, University of North Carolina at Chapel Hill, 125 MacNider Hall CB# 7005, Chapel Hill, NC, 27599, USA. kdallen@email.unc.edu. Health Services Research and Development Service, Durham VA Medical Center, Durham, NC, USA. kdallen@email.unc.edu. Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 3300 Thurston Bldg., CB# 7280, Chapel Hill, NC, 27599-7280, USA. Department of Medicine, University of North Carolina at Chapel Hill, 125 MacNider Hall CB# 7005, Chapel Hill, NC, 27599, USA. Health Services Research and Development Service, Durham VA Medical Center, Durham, NC, USA. Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. Department of Psychology, East Carolina University, Greenville, NC, USA. Department of Psychiatry and Behavioral Science, Duke University, Durham, NC, USA. Department of Medicine, Duke University Medical Center, Durham, NC, USA. Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, IL, USA. AN - 30227841 AU - Allen, K. D. AU - Arbeeva, L. AU - Cené, C. W. AU - Coffman, C. J. AU - Grimm, K. F. AU - Haley, E. AU - Keefe, F. J. AU - Nagle, C. T. AU - Oddone, E. Z. AU - Somers, T. J. AU - Watkins, Y. AU - Campbell, L. C. C2 - PMC6145122 DA - Sep 19 DO - 10.1186/s12891-018-2249-6 DP - NLM ET - 2018/09/20 IS - 1 KW - *Adaptation, Psychological Aged Arthralgia/diagnosis/ethnology/psychology/*therapy Catastrophization/diagnosis/ethnology/psychology/*therapy *Cognitive Behavioral Therapy *Culturally Competent Care Female Humans Male Middle Aged Osteoarthritis/diagnosis/ethnology/psychology/*therapy Osteoarthritis, Knee/diagnosis/ethnology/psychology/*therapy Pain Management/*methods Pain Measurement *Pain Perception Socioeconomic Factors Time Factors Treatment Outcome United States/epidemiology Health disparities Hip Knee Osteoarthritis Pain coping skills training Helsinki Declaration and was approved by the Institutional Review Boards of the University of North Carolina at Chapel Hill, Durham Veterans Affairs Medical Center, East Carolina University, and Duke University Health System. All study participants provided written informed consent. CONSENT FOR PUBLICATION: Not applicable COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. LA - eng N1 - 1471-2474 Allen, Kelli D Arbeeva, Liubov Cené, Crystal W Coffman, Cynthia J Grimm, Kimberlea F Haley, Erin Keefe, Francis J Nagle, Caroline T Oddone, Eugene Z Somers, Tamara J Watkins, Yashika Campbell, Lisa C AD-1408-19519/Patient-Centered Outcomes Research Institute/ Comparative Study Journal Article Multicenter Study Randomized Controlled Trial BMC Musculoskelet Disord. 2018 Sep 19;19(1):337. doi: 10.1186/s12891-018-2249-6. PY - 2018 SN - 1471-2474 SP - 337 ST - Pain coping skills training for African Americans with osteoarthritis study: baseline participant characteristics and comparison to prior studies T2 - BMC Musculoskelet Disord TI - Pain coping skills training for African Americans with osteoarthritis study: baseline participant characteristics and comparison to prior studies VL - 19 ID - 3959 ER - TY - JOUR AB - Research consistently indicates that children with sickle cell disease (SCD) face multiple risk factors for neurocognitive impairment. Despite this, no empirical research to date has examined the impact of neurocognitive functioning on quality of life for this pediatric group. Thus, the current study aims to examine the relationship between executive functioning and quality of life in a sample of children with SCD and further explore psychosocial and family/caregiver resources as moderators of this relationship. A total of 45 children with SCD aged 8 to 16 years and their caregivers completed measures of quality of life, behavioral ratings of executive functioning, and psychosocial functioning. Hierarchical linear regression models were utilized to determine the impact of executive functioning on quality of life and further test the interaction effects of proposed moderating variables. Controlling for age, pain, and socioeconomic status (SES), executive functioning was found to significantly predict child- and parent-reported quality of life among youth with SCD. Psychosocial resources of the primary caregiver or family was not found to moderate the relationship between executive functioning and quality of life. These results provide the first empirical evidence that lower executive skills negatively predict quality of life for children with SCD, supporting clinical and research efforts which aim to establish efficacious interventions that target cognitive decrements within this pediatric population. AN - WOS:000409243600001 AU - Allen, T. M. AU - Anderson, L. M. AU - Rothman, J. A. AU - Bonner, M. J. DO - 10.1080/09297049.2016.1205011 IS - 8 N1 - Allen, Taryn M. Anderson, Lindsay M. Rothman, Jennifer A. Bonner, Melanie J. Rothman, Jennifer/0000-0003-1582-2886 1744-4136 PY - 2017 SN - 0929-7049 SP - 889-906 ST - Executive functioning and health-related quality of life in pediatric sickle cell disease T2 - Child Neuropsychology TI - Executive functioning and health-related quality of life in pediatric sickle cell disease UR - ://WOS:000409243600001 VL - 23 ID - 2120 ER - TY - JOUR AB - More than 6.5 million children in the United States, approximately 13% of all students, miss 15 or more days of school each year. The rates of chronic absenteeism vary between states, communities, and schools, with significant disparities based on income, race, and ethnicity. Chronic school absenteeism, starting as early as preschool and kindergarten, puts students at risk for poor school performance and school dropout, which in turn, put them at risk for unhealthy behaviors as adolescents and young adults as well as poor long-term health outcomes. Pediatricians and their colleagues caring for children in the medical setting have opportunities at the individual patient and/or family, practice, and population levels to promote school attendance and reduce chronic absenteeism and resulting health disparities. Although this policy statement is primarily focused on absenteeism related to students' physical and mental health, pediatricians may play a role in addressing absenteeism attributable to a wide range of factors through individual interactions with patients and their parents and through community-, state-, and federal-level advocacy. AN - WOS:000457458700053 AU - Allison, M. A. AU - Attisha, E. AU - Lerner, M. AU - De Pinto, C. D. AU - Beers, N. S. AU - Gibson, E. J. AU - Gorski, P. AU - Kjolhede, C. AU - O'Leary, S. C. AU - Schumacher, H. AU - Weiss-Harrison, A. AU - Allison, M. AU - Ancona, R. AU - Holmes, B. W. AU - Okamoto, J. AU - Young, T. AU - Chang, H. AU - Seeley, K. AU - Adkins, S. H. AU - Combe, L. AU - Johnson, V. C. AU - Joshi, S. AU - Fekaris, N. AU - Grant, L. AU - Kataoka, S. AU - Leonard, S. AU - Guinn-Jones, M. AU - Domain, S. AU - Council Sch, Hlth C7 - e20183648 DA - Feb DO - 10.1542/peds.2018-3648 IS - 2 N1 - Allison, Mandy A. Attisha, Elliott Lerner, Marc De Pinto, Cheryl Duncan Beers, Nathaniel Savio Gibson, Erica J. Gorski, Peter Kjolhede, Chris O'Leary, Sonja C. Schumacher, Heidi Weiss-Harrison, Adrienne Allison, Mandy Ancona, Richard Holmes, Breena Welch Okamoto, Jeffrey Young, Thomas Chang, Hedy Seeley, Ken Adkins, Susan Hocevar Combe, Laurie Johnson, Veda Charmaine Joshi, Shashank Fekaris, Nina Grant, Linda Kataoka, Sheryl Leonard, Sandra Guinn-Jones, Madra Domain, Stephanie 1098-4275 PY - 2019 SN - 0031-4005 ST - The Link Between School Attendance and Good Health T2 - Pediatrics TI - The Link Between School Attendance and Good Health UR - ://WOS:000457458700053 VL - 143 ID - 1955 ER - TY - JOUR AB - Purpose To describe the demographic and clinical characteristics of children who presented with open femur fractures. Methods A retrospective chart review of all children treated for open femur fractures at the McGill University Health Center between 1980 and 2009 was conducted. Thirty-seven patients (28 males and 9 females) were identified. Union was determined clinically by the absence of pain, tenderness to palpation and crepitus with motion. Complications were reported. Results The mean age of the patients was 11.5 years (range 2.8-18.1 years). The mechanism of injury involved motor vehicle-related injuries in 70% of cases. There were 13 Grade I, 15 Grade II and 9 Grade III fractures. The treatment involved traction and hip spica in 11 patients, external fixator in nine patients, intramedullary nailing in seven patients, open reduction and internal fixation in six patients, and traction and an ischial weight bearing brace in four patients. Average time to union was 5.1 months (range 1.5-14.4 months). Infections occurred in ten patients, nine had delayed unions, two developed malunions, four had a refracture and four patients developed a limb length discrepancy[2 cm. Conclusions Open fractures of the femur are often accompanied by associated injuries, indicating the importance of early and comprehensive treatment. Treatment may include hip spica application in school-age children and solid intramedullary nails in adolescents. In children with multiple injuries, specifically those with higher fracture grades, treatment with an external fixator provides immediate stability of the fracture and allows early mobilization and ease of management of associated injuries. AN - WOS:000215405300005 AU - Allison, P. AU - Dahan-Oliel, N. AU - Jando, V. T. AU - Yang, S. S. AU - Hamdy, R. C. DA - Apr DO - 10.1007/s11832-011-0334-6 IS - 2 N1 - Allison, Patrick Dahan-Oliel, Noemi Jando, Victor T. Yang, Stephen Su Hamdy, Reggie C. Yang, Stephen/M-8177-2019 Yang, Stephen/0000-0003-3859-5110 1863-2548 PY - 2011 SN - 1863-2521 SP - 101-108 ST - Open fractures of the femur in children: analysis of various treatment methods T2 - Journal of Childrens Orthopaedics TI - Open fractures of the femur in children: analysis of various treatment methods UR - ://WOS:000215405300005 VL - 5 ID - 2504 ER - TY - JOUR AN - WOS:000541963200494 AU - Alsaggaf, F. AU - Coyne, I. DA - Jun DO - 10.1136/archdischild-2019-epa.493 N1 - Alsaggaf, Fatimah Coyne, Imelda 1468-2044 3 PY - 2019 SN - 0003-9888 SP - A211-A212 ST - IMPACT OF CHRONIC PAIN ON ADOLESCENTS' SCHOOL FUNCTIONING: A SYSTEMATIC REVIEW T2 - Archives of Disease in Childhood TI - IMPACT OF CHRONIC PAIN ON ADOLESCENTS' SCHOOL FUNCTIONING: A SYSTEMATIC REVIEW UR - ://WOS:000541963200494 VL - 104 ID - 1916 ER - TY - JOUR AB - Background: Recurrent abdominal pain (RAP) is a common complaint in children. Significant portion of them are of functional origin. This study aimed to assess the prevalence of abdominal pain-predominant functional gastrointestinal disorder (FGID) and its types in Jordanian school children. Methods: This is a school-based survey at south Jordan. Information using the self-reporting form of the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-RIII) - the official Arabic translation - was collected. Classes from academic years (grades) 6 - 8 were selected. SPSS Statistical Package Version 17 (IBM, Armonk, NY, USA) was used. Categorical data were analyzed using Fisher's exact test, and continuous data were analyzed using t-test. P < 0.05 was considered significant. Results: Five hundred questionnaires were distributed, and 454 returned answered (91%). Two hundred twenty-nine (50.8%) were males. The average age of participants was 12.7 years (11 - 15 years). One hundred sixteen (25.7%) had abdominal pain-predominant FGID. Seventy-nine (68%) of them were females. Forty-seven (10.6%) had irritable bowel syndrome (IBS). Thirty-six (8%), 17 (3.8%), 11 (2.4%) and five (1.1%) had abdominal migraine, functional abdominal pain, functional abdominal pain syndrome and functional dyspepsia, respectively. Conclusion: Abdominal pain-predominant FGID has become a major health issue in Jordanian children. One of four children between the ages of 11 and 15 years exhibits at least one abdominal pain-predominant FGID. The most common form of abdominal pain-predominant FGID in our children was IBS. Females are affected more often than males. Intestinal and extra-intestinal symptoms are seen regularly with abdominal pain-predominant FGIDs. AN - WOS:000215447500005 AU - Altamimi, E. M. AU - Al-Safadi, M. H. DA - Dec DO - 10.14740/gr627w IS - 5-6 N1 - Altamimi, Eyad M. Al-Safadi, Mohammad H. 1918-2813 PY - 2014 SN - 1918-2805 SP - 137-142 ST - Abdominal Pain-Predominant Functional Gastrointestinal Disorders in Jordanian School Children T2 - Gastroenterology Research TI - Abdominal Pain-Predominant Functional Gastrointestinal Disorders in Jordanian School Children UR - ://WOS:000215447500005 VL - 7 ID - 2274 ER - TY - JOUR AB - This descriptive, correlational study examined fatigue and potential biological and behavioral correlates in adolescents and young adults with sickle cell disease. Sixty adolescents and young adults with sickle cell disease completed the Brief Fatigue Inventory, Multidimensional Fatigue Symptom Inventory-Short Form, Patient Reported Outcomes Measurement Information System (PROMIS) fatigue short form and measures of pain, sleep quality, anxiety, depressive mood, stress, disease severity, and quality of life. Blood samples were obtained for hemoglobin and cytokines. Fatigue scores were mostly moderate in severity. Fatigue interfered to a moderate degree with daily activities and correlated significantly with pain, sleep quality, state and trait anxiety, depressive mood, stress, and quality of life. Fatigue was correlated with hemoglobin on the PROMIS measure. Fatigue was not correlated with cytokines or age, nor differed by disease severity. Fatigue was common in these adolescents and young adults, interfered with daily activities such as school, work and exercise, and significantly correlated with several potentially modifiable factors. As life expectancy increases in sickle cell disease, research is needed to test interventions to reduce fatigue. AD - 1Virginia Commonwealth University, Richmond, VA, USA. AN - 24378816 AU - Ameringer, S. AU - Elswick, R. K., Jr. AU - Smith, W. C2 - PMC3982311 C6 - NIHMS563570 DA - Jan-Feb DO - 10.1177/1043454213514632 DP - NLM ET - 2014/01/01 IS - 1 KW - Adolescent Adult Anemia, Sickle Cell/*physiopathology/psychology Cross-Sectional Studies *Fatigue Female Humans Male *Quality of Life Severity of Illness Index Young Adult adolescents and young adults fatigue pain quality of life sickle cell disease LA - eng N1 - 1532-8457 Ameringer, Suzanne Elswick, R K Jr Smith, Wally U54 HL090516/HL/NHLBI NIH HHS/United States P30 NR011403/NR/NINR NIH HHS/United States UL1RR031990/RR/NCRR NIH HHS/United States 1 R01 HL 64122/HL/NHLBI NIH HHS/United States 1 U54 HL090516/HL/NHLBI NIH HHS/United States 1 U10 HL083732/HL/NHLBI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural J Pediatr Oncol Nurs. 2014 Jan-Feb;31(1):6-17. doi: 10.1177/1043454213514632. Epub 2013 Dec 30. PY - 2014 SN - 1043-4542 (Print) 1043-4542 SP - 6-17 ST - Fatigue in adolescents and young adults with sickle cell disease: biological and behavioral correlates and health-related quality of life T2 - J Pediatr Oncol Nurs TI - Fatigue in adolescents and young adults with sickle cell disease: biological and behavioral correlates and health-related quality of life VL - 31 ID - 3986 ER - TY - JOUR AB - Objectives To better understand factors associated with the development and persistence of habit cough and to report use of self-hyponis for this condition. Study design A retrospective chart review was performed for 56 children and adolescents with habit cough. Interested patients were instructed in self-hypnosis for relaxation and to help ignore the cough-triggering sensation. Results The patients mean age was 10.7 years. The cough was triggered by upper respiratory infections in 59%, asthma in 13%, exercise in 5%, and eating in 4%. Onset of the cough occurred as early as 2 years, and its average duration was 13 months (range, 2 weeks to 7 years). There was a high incidence of abdominal pain and irritable bowel syndrome in the 50% of the patients who missed more than 1 week of school because of their cough. Among the 51 patients who used hypnosis, the cough resolved during or immediately after the initial hypnosis instruction session in 78% and within 1 month in an additional 12%.. Conclusions Habit cough is triggered by various physiologic conditions, related frequently to other diagnoses, and it is associated with significant school absence. Self-hypnosis offers a safe efficient treatment. AN - WOS:000188925800018 AU - Anbar, R. D. AU - Hall, H. R. DA - Feb DO - 10.1016/j.jpeds.2003.10.041 IS - 2 N1 - Anbar, RD Hall, HR 1097-6833 PY - 2004 SN - 0022-3476 SP - 213-217 ST - Childhood habit cough treated with self-hypnosis T2 - Journal of Pediatrics TI - Childhood habit cough treated with self-hypnosis UR - ://WOS:000188925800018 VL - 144 ID - 2797 ER - TY - JOUR AB - In a cross-sectional study of 2684 males from a range of occupations the prevalence rate for back pain was 20% (11% disc disease and 9% undetermined pain) and about half of these had pain related to the lower back with the remainder being located in the dorsoscapular or cervical regions. Follow up study of a cohort of 1249 of these workers over a two year period indicated that the incidence rate of low back pain in that group was about 1% per annum. When sickness absence certificates were studied the annual absence from back pain (all sites) was 1323 days per thousand employees. However, when confirmation was obtained from general practitioners about non-specific rheumatic diagnoses this figure rose to 1707 days. The prevalence of disc disease is higher among those engaged in heavy rather than among those in light work, and also among those required to adopt a chronic stooping posture at the place of work. A device designed to record lumbar EMG, antero-posterior and lateral posture of the lumbar spine and intra-abdominal pressure designed to be used in work places over a complete shift is described and traces obtained under laboratory conditions are presented. AD - Department of Community Medicine, United Medical School, Guy's Campus, London. AN - 2968632 AU - Anderson, J. A. AU - Otun, E. O. AU - Sweetman, B. J. DA - Jan-Jun DO - 10.1515/reveh.1987.7.1-2.121 DP - NLM ET - 1987/01/01 IS - 1-2 KW - Absenteeism Adolescent Adult Aged Back Pain/*etiology/prevention & control Cross-Sectional Studies Electromyography/instrumentation Humans Male Middle Aged Occupational Diseases/*etiology/prevention & control Risk Factors LA - eng N1 - Anderson, J A Otun, E O Sweetman, B J Journal Article Research Support, Non-U.S. Gov't Review Germany Rev Environ Health. 1987 Jan-Jun;7(1-2):121-60. doi: 10.1515/reveh.1987.7.1-2.121. PY - 1987 SN - 0048-7554 (Print) 0048-7554 SP - 121-60 ST - Occupational hazards and low back pain T2 - Rev Environ Health TI - Occupational hazards and low back pain VL - 7 ID - 3651 ER - TY - JOUR AB - Children with sickle cell disease (SCD) report fatigue in addition to acute and chronic pain, which can decrease overall health-related quality of life (HRQL). The primary objective of the current study was to investigate the relationship between fatigue and HRQL. Given limited prior research, secondary objectives included investigation of associations between fatigue and functional outcomes, including child neurocognitive and social-emotional functioning. Children aged 8 to 16 years (N=32) and a caregiver completed measures of fatigue, HRQL, pain, and neurocognitive and social-emotional functioning. Controlling for pain and number of SCD-related hospitalizations, hierarchical linear regression models were used to determine the impact of child-reported and parent-reported fatigue on child HRQL. Correlational analyses were used to explore the relationship between fatigue and additional child outcomes. Data indicated that children with SCD experience clinically relevant levels of fatigue, which independently predicts lower HRQL. Fatigue was also associated with lower working memory, executive functioning, and higher levels of internalizing symptoms. Given its observed impact on HRQL and relationship to functional outcomes, fatigue may be an important target of clinical, home, or school interventions. This practice may attenuate the burden of fatigue in these patients, and in turn, help improve the quality of life of children living with SCD. AN - WOS:000364330200002 AU - Anderson, L. M. AU - Allen, T. M. AU - Thornburg, C. D. AU - Bonner, M. J. DA - Nov DO - 10.1097/mph.0000000000000431 IS - 8 N1 - Anderson, Lindsay M. Allen, Taryn M. Thornburg, Courtney D. Bonner, Melanie J. 1536-3678 PY - 2015 SN - 1077-4114 SP - 584-589 ST - Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life T2 - Journal of Pediatric Hematology Oncology TI - Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life UR - ://WOS:000364330200002 VL - 37 ID - 2212 ER - TY - JOUR AB - PURPOSE: To compare the effectiveness of pain neuroscience education (PNE) and neck/shoulder exercises with no intervention in adolescents with chronic idiopathic neck pain (CINP). METHODS: Forty-three adolescents with CINP were randomly allocated to receive PNE and shoulder/neck exercises (n = 21) or no intervention (n = 22). Data on pain intensity, neck flexor and extensor muscles endurance, scapular stabilizers endurance, pain catastrophizing, anxiety, and knowledge of pain neurophysiology were collected. Measurements were taken before and after the intervention. RESULTS: All participants completed the study. Analysis using ANCOVA revealed a significant increase in the neck extensors endurance capacity (adjusted mean ± SE change = + 47.5 ± 13.5 s versus +14.2 ± 13.1 s) and knowledge of pain neurophysiology (adjusted mean ± SE change = + 9.8 ± 3.2 versus -0.6 ± 0.6) in the group receiving the intervention. A higher mean decrease in pain intensity, pain catastrophizing and anxiety and a higher mean increase in the scapular stabilizers endurance capacity were also found in the intervention group, but differences did not reach statistical significance. CONCLUSIONS: Results suggest a potential benefit of PNE and exercise for adolescents with CINP. Further studies with larger sample sizes are needed. AU - Andias, Rosa AU - Neto, Maritza AU - Silva, Anabela G. DA - 2018/09// DO - 10.1080/09593985.2018.1423590 DP - PubMed IS - 9 J2 - Physiother Theory Pract KW - Adolescent Adolescent Behavior adolescents Anxiety Catastrophization Chronic Pain Combined Modality Therapy Education exercise Exercise Therapy Exercise Tolerance Female Health Knowledge, Attitudes, Practice Humans intervention Male Muscle Strength Neck Muscles neck pain Neurosciences Patient Education as Topic Physical Endurance Portugal School Health Services Time Factors Treatment Outcome LA - eng PY - 2018 SN - 1532-5040 SP - 682-691 ST - The effects of pain neuroscience education and exercise on pain, muscle endurance, catastrophizing and anxiety in adolescents with chronic idiopathic neck pain T2 - Physiotherapy Theory and Practice TI - The effects of pain neuroscience education and exercise on pain, muscle endurance, catastrophizing and anxiety in adolescents with chronic idiopathic neck pain: a school-based pilot, randomized and controlled study UR - http://www.ncbi.nlm.nih.gov/pubmed/29319386 VL - 34 ID - 55 ER - TY - JOUR AB - OBJECTIVES: To investigate the relative importance of common physical and mental disorders with regard to the number of days out-of-role (DOR; number of days for which a person is completely unable to work or carry out normal activities because of health problems) in a population-based sample of adults in the São Paulo Metropolitan Area, Brazil. METHODS: The São Paulo Megacity Mental Health Survey was administered during face-to-face interviews with 2,942 adult household residents. The presence of 8 chronic physical disorders and 3 classes of mental disorders (mood, anxiety, and substance use disorders) was assessed for the previous year along with the number of days in the previous month for which each respondent was completely unable to work or carry out normal daily activities due to health problems. Using multiple regression analysis, we examined the associations of the disorders and their comorbidities with the number of days out-of-role while controlling for socio-demographic variables. Both individual-level and population-level associations were assessed. RESULTS: A total of 13.1% of the respondents reported 1 or more days out-of-role in the previous month, with an annual median of 41.4 days out-of-role. The disorders considered in this study accounted for 71.7% of all DOR; the disorders that caused the greatest number of DOR at the individual-level were digestive (22.6), mood (19.9), substance use (15.0), chronic pain (16.5), and anxiety (14.0) disorders. The disorders associated with the highest population-attributable DOR were chronic pain (35.2%), mood (16.5%), and anxiety (15.0%) disorders. CONCLUSIONS: Because pain, anxiety, and mood disorders have high effects at both the individual and societal levels, targeted interventions to reduce the impairments associated with these disorders have the highest potential to reduce the societal burdens of chronic illness in the São Paulo Metropolitan Area. AD - Section of Psychiatric Epidemiology - LIM 23, Department and Institute of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil. AN - 24270949 AU - Andrade, L. H. AU - Baptista, M. C. AU - Alonso, J. AU - Petukhova, M. AU - Bruffaerts, R. AU - Kessler, R. C. AU - Silveira, C. M. AU - Siu, E. R. AU - Wang, Y. P. AU - Viana, M. C. C2 - PMC3812560 DA - Nov DO - 10.6061/clinics/2013(11)02 DP - NLM ET - 2013/11/26 IS - 11 KW - *Absenteeism *Activities of Daily Living Adolescent Adult Brazil/epidemiology Chronic Pain/epidemiology Comorbidity Female Health Surveys/*statistics & numerical data Humans Male Mental Disorders/*epidemiology Mental Health/statistics & numerical data Prevalence Socioeconomic Factors Time Factors Urban Population/statistics & numerical data World Health Organization Young Adult LA - eng N1 - 1980-5322 Andrade, Laura Helena Baptista, Marcos C Alonso, Jordi Petukhova, Maria Bruffaerts, Ronny Kessler, Ronald C Silveira, Camila M Siu, Erica R Wang, Yuan-Pang Viana, Maria Carmen R01 DA016558/DA/NIDA NIH HHS/United States R01MH070884/MH/NIMH NIH HHS/United States R01-MH069864/MH/NIMH NIH HHS/United States R03-TW006481/TW/FIC NIH HHS/United States R13-MH066849/MH/NIMH NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Clinics (Sao Paulo). 2013 Nov;68(11):1392-9. doi: 10.6061/clinics/2013(11)02. PY - 2013 SN - 1807-5932 (Print) 1807-5932 SP - 1392-9 ST - Days out-of-role due to common physical and mental health problems: results from the São Paulo Megacity Mental Health Survey, Brazil T2 - Clinics (Sao Paulo) TI - Days out-of-role due to common physical and mental health problems: results from the São Paulo Megacity Mental Health Survey, Brazil VL - 68 ID - 3335 ER - TY - JOUR AB - PURPOSE: Cognitive behavioral therapy (CBT)-based programs delivered by trained community members could improve functioning and pain in individuals who lack access to such programs. We tested the effectiveness of a peer-delivered diabetes self-management program integrating CBT principles in improving physical activity, functional status, pain, quality of life (QOL), and health outcomes in individuals with diabetes and chronic pain. METHODS: In this community-based, cluster-randomized controlled trial, intervention participants received a 3-month, peer-delivered, telephone-administered program. Attention control participants received a peer-delivered general health advice program. Outcomes were changes in functional status and pain (Western Ontario and McMaster Universities Osteoarthritis Index), QOL (Short Form 12), and physiologic measures (hemoglobin A(1c), systolic blood pressure, body mass index); physical activity was the explanatory outcome. RESULTS: Of 195 participants with follow-up data, 80% were women, 96% African Americans, 74% had annual income <$20,000, and 64% had high school education or less. At follow-up, compared with controls, intervention participants had greater improvement in functional status (-10 ± 13 vs -5 ± 18, P = .002), pain (-10.5 ± 19 vs -4.8 ± 21, P = .01), and QOL (4.8 ± 8.8 vs 3.8 ± 8.8, P = .001). Physiologic measures did not change significantly in either group. At 3 months, a greater proportion of intervention than control participants reported no pain or did other forms of exercise when pain prevented them from walking for exercise. CONCLUSION: This peer-delivered CBT-based intervention improved functioning, pain, QOL, and self-reported physical activity despite pain in individuals with diabetes and chronic pain. Trained community members can deliver effective CBT-based interventions in rural and under-resourced communities. AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin. Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama. Department of Medicine, Weill Cornell Medicine, New York, New York mms9024@med.cornell.edu. AN - 31937528 AU - Andreae, S. J. AU - Andreae, L. J. AU - Richman, J. S. AU - Cherrington, A. L. AU - Safford, M. M. C2 - PMC7227468 DA - Jan DO - 10.1370/afm.2469 DP - NLM ET - 2020/01/16 IS - 1 KW - Aged Chronic Pain Cluster Analysis Cognitive Behavioral Therapy/*methods Diabetes Mellitus/psychology/*therapy Female Humans Male *Mentoring Middle Aged Pain Management/psychology Physical Functional Performance Quality of Life Rural Population Self-Management/*education *chronic pain *cognitive behavioral therapy *community health workers *community peer coaches *diabetes LA - eng N1 - 1544-1717 Andreae, Susan J Andreae, Lynn J Richman, Joshua S Cherrington, Andrea L Safford, Monika M R18 HS019239/HS/AHRQ HHS/United States Journal Article Multicenter Study Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S. Ann Fam Med. 2020 Jan;18(1):15-23. doi: 10.1370/afm.2469. PY - 2020 SN - 1544-1709 (Print) 1544-1709 SP - 15-23 ST - Peer-Delivered Cognitive Behavioral Training to Improve Functioning in Patients With Diabetes: A Cluster-Randomized Trial T2 - Ann Fam Med TI - Peer-Delivered Cognitive Behavioral Training to Improve Functioning in Patients With Diabetes: A Cluster-Randomized Trial VL - 18 ID - 3041 ER - TY - JOUR AB - In childhood and adolescence, migraine is the main primary headache. This diagnosis is largely underestimated and misdiagnosed in the pediatric population. Because of the lack of specific biologic markers, specific investigation tools or brain imaging techniques, these clinical entities are too often considered to be a psychological illness. Migraine is a severe headache evolving by stereotyped attacks associated with marked digestive symptoms (nausea and vomiting); throbbing pain and sensitivity to sound or light are common symptoms; the attack is sometimes preceded by a visual or sensory aura. During attacks, pain intensity is severe; most of the children have to lie down. Abdominal pain is frequently associated, rest brings relief and sleep often ends the attack. The prevalence of migraine varies between 5 percent and 10 percent in childhood. In children, the duration of the headache is quite often shorter than in adults; it is more often frontal and bilateral (2/3 of cases) than one-sided. Migraine is a disabling illness: children with migraine miss more school days in a school year than their matched controls. Migraine episodes are frequently triggered by several factors: emotional stress (school pressure, vexation, excitement: upset), hypoglycemia, lack of sleep or excess (week end migraine), sensorial stimulation (loud noise, bright light, strong odor, heat or cold..), sympathetic stimulation (sports, physical exercise). Treatment must be given early at onset of attacks; oral ibuprofen (10 mg/kg) is recommended. If the oral route in not available because of nausea or vomiting, the rectal or nasal routes can be used. Triptan can be prescribed (body weight above 30 kg) when NSAID (prescribed at right dose and time) fail to abort the attack. Non-drug treatments (relaxation training, self hypnosis, biofeedback) have shown to have good efficacy as prophylactic measures. Daily prophylactic drug treatments are prescribed in second line after failure of non-drug treatment. AN - WOS:000230344900016 AU - Annequin, D. DA - Jul IS - 6-7 N1 - Annequin, D Annequin, Daniel/0000-0001-6425-4016 2213-0004 PY - 2005 SN - 0035-3787 SP - 687-688 ST - Migraine in childhood T2 - Revue Neurologique TI - Migraine in childhood UR - ://WOS:000230344900016 VL - 161 ID - 2759 ER - TY - JOUR AB - In childhood and adolescence, migraine is the main essential chronic headache. This diagnosis is extensively underestimated and misdiagnosed in pediatric population. Lacks of specific biologic marker, specific investigation or brain imaging reduce these clinical entities too often to a psychological illness. Migraine is a severe headache evolving by stereotyped crises associated with marked digestive symptoms (nausea and vomiting); throbbing pain, sensitivity to sound, light are usual symptoms; the attack is sometimes preceded by a visual or sensory aura. During attacks, pain intensity is severe, most of children must lie down. Abdominal pain is frequently associated rest brings relief and sleep ends often the attack The prevalence of the migraine varies between 5p.100 and 10p.100 in childhood. At childhood, headache duration is quite often shorter than in adult population, it is more often frontal, bilateral (2/3 of cases) that one-sided. Migraine is a disabling illness: children with migraine lost more school days in a school year, than a matched control group. Migraine episodes are frequently triggered by several factors: emotional stress (school pressure, vexation, excitement upset), hypoglycemia, lack of sleep or excess (week end migraine), sensorial stimulation (loud noise, bright light, strong odor, heat or cold...), sympathetic stimulation (sport, physical exercise). Attack treatments must be given at the early beginning of the crisis; oral dose of ibuprofen (10mg/kg) is recommended. If the oral route in not available when nausea or vomiting occurs, the rectal or nasal routes have then to be used. Non pharmacological treatments (biofeedback and interventions combining progressive muscle relaxation) have shown to have good efficacy as prophylactic measure. Daily prophylactic pharmacological treatments are prescribed in second line after failure of non-pharmacological treatment. AN - WOS:000166543700011 AU - Annequin, D. AU - Dumas, C. AU - Tourniaire, B. AU - Massiou, H. N1 - Annequin, D Dumas, C Tourniaire, B Massiou, H 6th Congress on Therapeutics and Neurology on Headaches Dec 03-04, 1999 Paris, france 4 PY - 2000 SN - 0035-3787 SP - 68-74 ST - Migraine and chronic headache in children T2 - Revue Neurologique TI - Migraine and chronic headache in children UR - ://WOS:000166543700011 VL - 156 ID - 2872 ER - TY - JOUR AB - In childhood and adolescence, migraine is the main primary headache. This diagnosis is extensively underestimated and misdiagnosed in pediatric population. Lacks of specific biologic marker, specific investigation or brain imaging reduce these clinical entities too often to a psychological illness. Migraine is a severe headache evolving by stereotyped crises associated with marked digestive symptoms (nausea and vomiting); throbbing pain, sensitivity to sound, light are usual symptoms; the attack is sometimes preceded by a visual or sensory aura. During attacks, pain intensity is severe, most of children must lie down. Abdominal pain is frequently associated, rest brings relief and sleep ends often the attack. The prevalence of the migraine varies between 5% and 10% in childhood. At childhood, headache duration is quite often shorter than in adult population, it is more often frontal, bilateral (2/3 of cases) that one-sided. Migraine is a disabling illness: children with migraine lost more school days in a school year, than a matched control group. Migraine episodes are frequently triggered by several factors: emotional stress (school pressure, vexation, excitement: upset), hypoglycemia, lack of sleep or excess (week end migraine), sensorial stimulation (loud noise, bright light, strong odor, heat or cold...), sympathetic stimulation (sport, physical exercise). Attack treatments must be given at the early beginning of the crisis; oral dose of ibuprofen (10 mg/kg) is recommended. If the oral route is not available when nausea or vomiting occurs, the rectal or nasal routes have then to be used. Non pharmacological treatments (relaxation training, self hypnosis, biofeedback) have shown to have good efficacy as prophylactic measure. Daily prophylactic pharmacological treatments are prescribed in second line after failure of non-pharmacological treatment. (c) 2005 Elsevier SAS. Tous droits reserves. AN - WOS:000229455400029 AU - Annequin, D. AU - Tourniaire, B. DA - May DO - 10.1016/j.arcped.2004.07.007 IS - 5 N1 - Annequin, D Tourniaire, B Annequin, Daniel/0000-0001-6425-4016 1769-664x PY - 2005 SN - 0929-693X SP - 624-629 ST - Migraine and headache in childhood T2 - Archives De Pediatrie TI - Migraine and headache in childhood UR - ://WOS:000229455400029 VL - 12 ID - 2765 ER - TY - JOUR AB - Although migraine is the main chronic headache in childhood and adolescence, it remains extensively misdiagnosed. Schematically, migraine is a severe headache evolving by stereotyped attacks frequently associated with marked digestive symptoms (nausea, vomiting, abdominal pain). Throbbing pain, sensitivity to sound, and light (and sometimes odors) are frequent additional symptoms. The attack is sometimes preceded by a visual or sensory aura. Rest brings relief, and sleep often ends the attack. Childhood migraine prevalence varies between 5 and 10%. Migraine episodes are frequently triggered by several factors: emotional stress (school pressure, vexation, excitement, upset), hypoglycemia, lack or excess of sleep (weekend migraine), sensory stimulation (loud noise, bright light, strong odor, heat or cold, etc.), sympathetic stimulation (sport, physical exercise). Attack treatments must be given at an early stage, oral ibuprofen (10 mg/kg) being particularly recommended. If the oral route is not available because of nausea or vomiting, rectal or nasal routes have then to be used. Non-pharmacological treatments (biofeedback and interventions combining progressive muscle relaxation) have demonstrated good efficacy as prophylactic measures. Daily prophylactic pharmacological treatments are prescribed as the second line after failure of non-pharmacological treatments. AD - Unité fonctionnelle d'analgésie pédiatrique, hôpital d'enfants Armand-Tousseau, Paris, France. AN - 11028209 AU - Annequin, D. AU - Tourniaire, B. AU - Dumas, C. DA - Sep DO - 10.1016/s0929-693x(00)90016-2 DP - NLM ET - 2000/10/12 IS - 9 KW - Abdominal Pain/etiology Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Child Child Welfare Diagnosis, Differential Humans Ibuprofen/therapeutic use Incidence Migraine Disorders/diagnosis/epidemiology/*etiology Nausea/etiology Stress, Psychological Vomiting/etiology LA - fre N1 - Annequin, D Tourniaire, B Dumas, C English Abstract Journal Article France Arch Pediatr. 2000 Sep;7(9):985-90. doi: 10.1016/s0929-693x(00)90016-2. OP - La migraine, pathologie méconnue chez l'enfant. PY - 2000 SN - 0929-693X (Print) 0929-693x SP - 985-90 ST - [Migraine, misunderstood pathology in children] T2 - Arch Pediatr TI - [Migraine, misunderstood pathology in children] VL - 7 ID - 3569 ER - TY - JOUR AB - In all forms of rheumatic disease in childhood, early and accurate diagnosis is essential. The aims of therapy in juvenile arthritis are pain relief and the preservation of joint function while maintaining normal growth and psychological development. As management is complex it will require a coordinated, multi-disciplinary team in which good communication between all members is a priority. Many families will need some form of counselling, whether it be from a social worker, the paediatrician involved, or a psychologist. This is particularly important in adolescence, whether the disease has commenced at this time or whether the child has gone into adolescence with a chronic illness. AN - WOS:A1994PB89700021 AU - Ansell, B. M. DA - Sep-Oct N1 - Ansell, bm 2nd European Conference on Pediatric Autoimmune and Rheumatic Diseases Sep 07-10, 1994 Pavia, italy 10 PY - 1994 SN - 0392-856X SP - S113-S116 ST - HOW SHOULD PEDIATRIC RHEUMATOLOGY BE DELIVERED T2 - Clinical and Experimental Rheumatology TI - HOW SHOULD PEDIATRIC RHEUMATOLOGY BE DELIVERED UR - ://WOS:A1994PB89700021 VL - 12 ID - 2947 ER - TY - JOUR AB - Objective To determine the extent to which parental perceptions of child vulnerability predict school and social adjustment in children with chronic illness. Methods Sixty-nine child-parent dyads were recruited from pediatric rheumatology and pulmonary clinics. Parents completed a self-report measure of parental perceptions of child vulnerability. Children completed measures of social adjustment. Parents also provided written permission to obtain school attendance records. Physicians provided a global assessment of children's disease severity. Results Increased parental perceptions of child vulnerability were related to increased social anxiety in children, even after controlling for child age and disease severity. Lower levels of parental education related to both increased perceptions of child vulnerability and increased school absences. Conclusions Health providers should assess parental beliefs and parenting practices in assessing the adjustment of children with chronic illness. Moreover, interventions aimed at enhancing child adjustment to chronic illness might best target parents as well as children. AN - WOS:000182079000005 AU - Anthony, K. K. AU - Gil, K. M. AU - Schanberg, L. E. DA - Apr-May DO - 10.1093/jpepsy/jsg005 IS - 3 N1 - Anthony, KK Gil, KM Schanberg, LE PY - 2003 SN - 0146-8693 SP - 185-190 ST - Brief report: Parental perceptions of child vulnerability in children with chronic illness T2 - Journal of Pediatric Psychology TI - Brief report: Parental perceptions of child vulnerability in children with chronic illness UR - ://WOS:000182079000005 VL - 28 ID - 2812 ER - TY - JOUR AU - Apley, J. AU - Naish, N. DA - 1958/04// DO - 10.1136/adc.33.168.165 DP - PubMed IS - 168 J2 - Arch Dis Child KW - Abdomen ABDOMEN/diseases Abdominal Pain Child Disease Gastrointestinal Diseases Humans LA - eng PY - 1958 SN - 0003-9888 SP - 165-170 ST - Recurrent abdominal pains T2 - Archives of Disease in Childhood TI - Recurrent abdominal pains: a field survey of 1,000 school children UR - http://www.ncbi.nlm.nih.gov/pubmed/13534750 VL - 33 ID - 92 ER - TY - CHAP AB - OBJECTIVE: To identify and summarize evidence from empirical studies relating to the cost of care and the economic impact of chronic headache. SEARCH STRATEGY: We used a strategy combining the MeSH term "headache" (exploded) with terms and text words pertaining to cost and resource utilization to search the MEDLINE, HealthStar, and CINAHL databases for relevant studies published between January 1966 and December 1996. Other computerized bibliographic databases, textbooks, and experts were also utilized. SELECTION CRITERIA: We considered full reports of original empirical research, published in English, which concerned an adult (non-pediatric) subject population suffering from primary headache (i.e., not traumatic, post-lumbar puncture, or other secondary headaches), reported data relevant to the economic impact of chronic headache on medical resource utilization or work loss, and met minimal methodological criteria related to the validity of cost or utilization measures. DATA COLLECTION AND ANALYSIS: From studies of patients with primary headache, data were collected on: rates and predictors of headache-related and total health care provider consultation, emergency department utilization, hospitalization, prescription and non-prescription drug use, and work loss and disability. Data were annualized when necessary to make results of different studies more comparable. MAIN RESULTS: Of over 400 citations identified, 126 appeared to meet screening criteria, and 35 met all criteria and were included in this review. While between 56% and 91% of chronic headache sufferers seek the care of a health care provider, only one-third report having received a diagnosis of their condition. While most patients with migraine consult a health care provider at some point, most do not continue to seek medical care. Relatively fewer patients with tension-type headache seek medical care. A small sub-population of chronic headache sufferers accounts for a high proportion of provider consultations, emergency department visits, and prescription drug claims. The vast majority of headache sufferers have used drugs to treat their headaches at some time. Non-prescription drugs are used more often than prescription drugs. Patients with more severe headache symptoms are both more likely to consult a health care provider about their headaches and more likely to use prescription medications. Use of prescription drugs for headache increases with age and is higher among women than men. About two-thirds of patients who try prescription medications do not continue to use them, citing the availability of effective non-prescription drugs, unwanted side-effects, and inadequate relief among the reasons for discontinuing prescription drug use. Rates of absenteeism due to headache of 2 to 4.3 days per year were reported in employee and community studies, while higher rates, ranging from 14.3 to 61 days per year, were observed in two studies conducted in clinical settings. These average figures obscure the fact that while many to most patients miss no days of work or school, a relatively small proportion of subjects accounts for many missed days. While headache does cause a large number of absences from work, it appears that many headache sufferers stay on the job, functioning with significantly reduced effectiveness, when they have a headache. CONCLUSIONS: Chronic headache sufferers represent a diverse population which is difficult to study. Population-based studies suggest that many headache sufferers do not seek medical care for their headaches and do not use prescription drugs to treat them. Studies conducted among headache patients in clinical settings suggest that these patients have more severe headache symptoms, use more prescriptions drugs, and are heavier users of medical resources. Data from both types of studies must be considered if the comprehensive cost of chronic headache is to be estimated. AD - Center for Clinical Health Policy Research, Duke University AN - 20734516 AU - Archibald, N. AU - Lipscomb, J. AU - McCrory, D. C. CY - Rockville (MD) LA - eng N1 - Archibald, Nancy Lipscomb, Joseph McCrory, Douglas C Review Book NBK45258 [bookaccession] PB - Agency for Health Care Policy and Research (US) PY - 1999 ST - AHRQ Technical Reviews T2 - Resource Utilization and Costs of Care for Treatment of Chronic Headache TI - AHRQ Technical Reviews ID - 4191 ER - TY - JOUR AB - Background: Fatigue is common in patients with JIA and affects daily life negatively. We assessed the presence and severity of fatigue in patients with JIA, including factors presumed associated with fatigue (e.g., disease activity, disability, pain, physical activity, exercise capacity, and self-efficacy), and whether fatigue is related to participation in physical education classes, school attendance, and sports frequency. Methods: The current study used baseline data of 80 patients with JIA (age 8-13) who participated in an intervention aimed at promoting physical activity. Primary outcome measurements were fatigue, assessed using the Pediatric-Quality-of-Life-Inventory (PedsQl)-Fatigue-scale and energy level assessed using a VAS scale. Other outcome measurements were disease activity (VAS Physician Global Assessment Scale), disability (Childhood Health Assessment Questionnaire), physical activity (accelerometer), exercise capacity (Bruce treadmill test), self-efficacy (Childhood Arthritis Self-Efficacy Scale), and participation (self-report). Results: Sixty percent of patients with JIA suffered from daily low-energy levels; 27% suffered from very low-energy levels more than half the week. Low energy levels were best predicted by disability and low physical activity. Fatigue measured with the PEDsQL was higher compared to the control-population. Disability and low self-efficacy were main predictors of fatigue. Self-efficacy was a predictor of fatigue but did not act as moderator. Fatigue was a predictor for sports frequency but not for school attendance. Conclusion: Fatigue is a significant problem for JIA patients. Interventions aimed at reducing perceived disability, stimulating physical activity, and enhancing self-efficacy might reduce fatigue and thereby enhance participation. AN - WOS:000390277400001 AU - Armbrust, W. AU - Lelieveld, Ohtm AU - Tuinstra, J. AU - Wulffraat, N. M. AU - Bos, Gjfj AU - Cappon, J. AU - van Rossum, M. A. J. AU - Sauer, P. J. J. AU - Hagedoorn, M. C7 - 65 DA - Dec DO - 10.1186/s12969-016-0125-1 N1 - Armbrust, Wineke Lelieveld, Otto H. T. M. Tuinstra, Jolanda Wulffraat, Nico M. Bos, G. J. F. Joyce Cappon, Jeannette van Rossum, Marion A. J. Sauer, Pieter J. J. Hagedoorn, Mariet Wulffraat, Nico M/AAE-8929-2020; Hagedoorn, Mariet/B-5056-2010 Wulffraat, Nico M/0000-0001-9548-5562; Hagedoorn, Mariet/0000-0003-3444-3662 1546-0096 PY - 2016 ST - Fatigue in patients with Juvenile Idiopathic Arthritis: relationship to perceived health, physical health, self-efficacy, and participation T2 - Pediatric Rheumatology TI - Fatigue in patients with Juvenile Idiopathic Arthritis: relationship to perceived health, physical health, self-efficacy, and participation UR - ://WOS:000390277400001 VL - 14 ID - 2126 ER - TY - JOUR AB - Chronic pelvic pain (CPP) affects a significant number of women worldwide. Internationally, people with endometriosis report significant negative impact across many areas of their life. We aimed to use an online survey using the EndoCost tool to determine if there was any difference in the impact of CPP in those with vs. those without a confirmed diagnosis of endometriosis, and if there was any change in diagnostic delay since the introduction of clinical guidelines in 2005. 409 responses were received; 340 with a diagnosis of endometriosis and 69 with no diagnosis. People with CPP, regardless of diagnosis, reported moderate to severe dysmenorrhea and non-cyclical pelvic pain. Dyspareunia was also common. Significant negative impact was reported for social, academic, and sexual/romantic relationships in both cohorts. In the endometriosis cohort there was a mean diagnostic delay of eight years, however there was a reduction in both the diagnostic delay (p < 0.001) and number of doctors seen before diagnosis (p < 0.001) in those presenting more recently. Both endometriosis and CPP have significant negative impact. Whilst there is a decrease in the time to diagnosis, there is an urgent need for improved treatment options and support for women with the disease once the diagnosis is made. AD - NICM Health Research Institute, Western Sydney University, Penrith, NSW, 2751, Australia. m.armour@westernsydney.edu.au. Translational Health Research Institute, Western Sydney University, Penrith, NSW, 2751, Australia. m.armour@westernsydney.edu.au. NICM Health Research Institute, Western Sydney University, Penrith, NSW, 2751, Australia. School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia. Department of Sociology/Anthropology, Middlebury College, Middlebury, VT, USA. Translational Health Research Institute, Western Sydney University, Penrith, NSW, 2751, Australia. AN - 33004965 AU - Armour, M. AU - Sinclair, J. AU - Ng, C. H. M. AU - Hyman, M. S. AU - Lawson, K. AU - Smith, C. A. AU - Abbott, J. C2 - PMC7529759 research grants and donations from foundations, universities, government agencies and industry. Sponsors and donors provide untied and tied funding for work to advance the vision and mission of the Institute. This study was not specifically supported by donor or sponsor funding to NICM. MA is a member of the clinical advisory board for Endometriosis Australia. JA: Medical Director, Endometriosis Australia (NFP). The other authors declare no competing interest. DA - Oct 1 DO - 10.1038/s41598-020-73389-2 DP - NLM ET - 2020/10/03 IS - 1 KW - Activities of Daily Living/psychology Adolescent Adult Australia Chronic Disease Delayed Diagnosis/*statistics & numerical data Endometriosis/*diagnosis/psychology Female Humans Middle Aged Pelvic Pain/*diagnosis/psychology *Quality of Life/psychology Surveys and Questionnaires Young Adult LA - eng N1 - 2045-2322 Armour, Mike Sinclair, Justin Ng, Cecilia H M Hyman, Mikayla S Lawson, Kenny Smith, Caroline A Abbott, Jason Journal Article Sci Rep. 2020 Oct 1;10(1):16253. doi: 10.1038/s41598-020-73389-2. PY - 2020 SN - 2045-2322 SP - 16253 ST - Endometriosis and chronic pelvic pain have similar impact on women, but time to diagnosis is decreasing: an Australian survey T2 - Sci Rep TI - Endometriosis and chronic pelvic pain have similar impact on women, but time to diagnosis is decreasing: an Australian survey VL - 10 ID - 3677 ER - TY - JOUR AB - Study Design: Retrospective case series. Purpose: The aim of the study is to report the clinical characteristics, early diagnosis, management, and outcome of children with multidrug-resistant (MDR) tubercular spondylodiscitis and to assess the early detection of rifampicin resistance using the Xpert MTB/RIF assay. Overview of Literature: MDR tuberculosis is on the rise, especially in developing countries. The incidence rate of MDR has been reported as 8.9% in children. Methods: A retrospective study of children aged <15 years of age who were diagnosed and treated for MDR tuberculosis of the spine was conducted. Confirmed cases of MDR tuberculosis and patients who had completed at least 18 months of second-line antituberculous treatment (ATT) were included. Children were treated with ATT for 24 months according to drug-susceptibility-test results. Outcome measures included both clinical and radiological measures. Clinical measures included pain, neurological status, and return to school. Radiological measures included kyphosis correction and healing status. Results: Six children with a mean age of 10 years were enrolled. The mean follow-up period was 12 months. All the children had previous history of treatment with first-line ATT, with an average of 13.6 months before presentation. Clinically, 50% (3/6 children) had psoas abscesses and 50% had spinal deformities. Radiologically, 50% (three of six children) had multicentric involvement. Three children underwent surgical decompression; two needed posterior stabilization with pedicle screws posteriorly followed by anterior column reconstruction. Early diagnosis of MDR was achieved in 83.3% (five of six children) with Xpert MTB/RIF assay. A total of 83.3% of the children were cured of the disease. Conclusions: Xpert MTB/RIF assay confers the advantage of early detection, with initiation of MDR drugs within an average of 10.5 days from presentation. The cost of second-line ATT drugs was 30 times higher than that of first-line ATT. AN - WOS:000457550900011 AU - Arockiaraj, J. AU - Robert, M. AU - Rose, W. AU - Amritanand, R. AU - David, K. S. AU - Krishnan, V. DA - Feb DO - 10.31616/asj.2017.0217 IS - 1 N1 - Arockiaraj, Justin Robert, Magdalenal Rose, Winsley Amritanand, Rohit David, Kenny Samuel Krishnan, Venkatesh 1976-7846 PY - 2019 SN - 1976-1902 SP - 77-85 ST - Early Detection and Analysis of Children with Multidrug-Resistant Tuberculosis of the Spine T2 - Asian Spine Journal TI - Early Detection and Analysis of Children with Multidrug-Resistant Tuberculosis of the Spine UR - ://WOS:000457550900011 VL - 13 ID - 1953 ER - TY - JOUR AB - OBJECTIVE: This study reports the pain sensitivity of children with headache and their family members, as well as the prevalence of recurring aches, psychosocial life, and family environment of children with headache at preschool age. DESIGN: A representative population-based sample of 1443 families expecting their first child were followed over 7 years. A screening questionnaire relating to the child's headache was sent to parents of a representative sample of 1132 6-year-old children. Of 144 children suffering from headache, 106 (76%) were examined and interviewed clinically. Ninety-six children with primary headache (58 migraine and 38 tension-type headache children) and matched controls (n = 96) were included in further examinations. RESULTS: Children with headache were more often extremely sensitive to pain according to their parents, were more excited about physical examinations, cried more often during blood sampling or vaccination, avoided play or games more often because they were afraid of hurting themselves, and had recurring abdominal and growing pains more often than did control children. The fathers of children with headache were more often extremely sensitive to pain. Children with headache reacted with somatic symptoms, usually with pain and functional intestinal disorders in stress situations, felt more tired, and had more ideations of death during the previous month. They had also had more problems in day care and fewer hobbies such as scout or club meetings than did control children. More mothers of tension-type headache children than those of migraine children reported that they were considerably sensitive to pain. Tension-type headache children also had a poorer family environment; the family atmosphere was more often unhappy and the relationship between the parents was more often distant than in the families of children with migraines. CONCLUSIONS: In addition to somatic factors, it is important to consider the child's pain sensitivity, reaction to various stress situations, and family functioning when studying childhood headache. The child's coping mechanisms can be supported by information given by the parents. School entry can be considered a suitable period for careful investigation into possible occurrence of headache and also for giving information about headache and its management. AD - Department of Child Neurology, University of Turku, Finland. minna.aromaa@tyks.fi AN - 10920150 AU - Aromaa, M. AU - Sillanpää, M. AU - Rautava, P. AU - Helenius, H. DA - Aug DO - 10.1542/peds.106.2.270 DP - NLM ET - 2000/08/02 IS - 2 Pt 1 KW - Child Child, Preschool Chronic Disease Family/*psychology Finland Follow-Up Studies Headache/*psychology Humans Migraine Disorders/psychology Pain Measurement *Pain Threshold Parent-Child Relations Social Adjustment Social Environment Somatoform Disorders/psychology Tension-Type Headache/psychology LA - eng N1 - Aromaa, M Sillanpää, M Rautava, P Helenius, H Journal Article Research Support, Non-U.S. Gov't United States Pediatrics. 2000 Aug;106(2 Pt 1):270-5. doi: 10.1542/peds.106.2.270. PY - 2000 SN - 0031-4005 (Print) 0031-4005 SP - 270-5 ST - Pain experience of children with headache and their families: A controlled study T2 - Pediatrics TI - Pain experience of children with headache and their families: A controlled study VL - 106 ID - 3208 ER - TY - JOUR AB - OBJECTIVE: Our objective was to study the prevalence of different headache types, characterizations, and triggers of headache in Finnish children starting school. METHODS: Questionnaires were sent to 1,132 families with 6-year-old children. Children with headache disturbing their daily activities (n=96) and an asymptomatic control group of children (n=96) participated in a clinical interview and examination. RESULTS: Children with headache had significantly more bruxism (odds ratio [OR], 1.9; 95% CI, 1.0 to 3.4), tenderness in the occipital muscle insertion areas (OR, 4.8; 95% CI, 1.8 to 12.7), and tenderness in the temporomandibular joint areas (OR, 2.8; 95% CI, 1.3 to 6.0). They also had more travel sickness (OR, 3.4; 95% CI, 1.7 to 6.7) than control children. Eating ice cream (OR, 5.3; 95% CI, 1.4 to 20.3), fear (OR, 3.7; 95% CI, 1.2 to 11.2), and anxiety (OR, 3.2; 95% CI, 1.0 to 10.8) triggered headache more often in migraineurs than in children with tension-type headache. Children with migraine also reported more frequently abdominal (OR, 5.6; 95% CI, 1.7 to 18.1) and other (OR, 3.5; 95% CI, 1.2 to 9.8) pain concurrently with headache, and they used medication for pain relief more often (OR, 3.1; 95% CI, 1.0 to 9.5). CONCLUSIONS: Headache classification in children may be improved by palpation of occipital muscle insertions and temporomandibular joint areas, and by discerning a history of triggering events and concurrent symptoms. AD - Department of Child Neurology, University of Turku, Finland. AN - 9633718 AU - Aromaa, M. AU - Sillanpää, M. L. AU - Rautava, P. AU - Helenius, H. DA - Jun DO - 10.1212/wnl.50.6.1729 DP - NLM ET - 1998/06/20 IS - 6 KW - Bruxism/complications/epidemiology Child Facial Muscles/physiopathology Female Headache/complications/*epidemiology/therapy Humans Male Migraine Disorders/physiopathology Motion Sickness/complications/epidemiology Pain/complications/epidemiology Prevalence Reference Values *Students Surveys and Questionnaires Temporomandibular Joint/physiopathology Tension-Type Headache/etiology/physiopathology LA - eng N1 - Aromaa, M Sillanpää, M L Rautava, P Helenius, H Journal Article Research Support, Non-U.S. Gov't United States Neurology. 1998 Jun;50(6):1729-36. doi: 10.1212/wnl.50.6.1729. PY - 1998 SN - 0028-3878 (Print) 0028-3878 SP - 1729-36 ST - Childhood headache at school entry: a controlled clinical study T2 - Neurology TI - Childhood headache at school entry: a controlled clinical study VL - 50 ID - 3521 ER - TY - JOUR AB - Increased prescribing of opioids has been associated with an epidemic of nonmedical prescription opioid use in the United States; adolescents and young adults are particularly vulnerable to opioid misuse. The role of physicians as health care providers, educators, and confidants for their adolescent patients equips them to intervene in adolescent opioid misuse. The authors advocate for improving the education of physicians and residents regarding opioid use and misuse among adolescents. To achieve this, we can require residency education that includes opioid misuse and appropriate prescribing, widely disseminate existing resources on management of pain and opioid misuse, and develop pain management and addiction mentorship programs. AN - WOS:000452676700004 AU - Arora, N. S. AU - Marcotte, K. M. AU - Hopper, J. A. DO - 10.1080/08897077.2017.1356788 IS - 1 N1 - Arora, Nonie S. Marcotte, Kayla M. Hopper, John A. Hopper, John/AAJ-5878-2021 Hopper, John/0000-0003-2445-8043; Arora, Nonie/0000-0001-8399-3818 1547-0164 PY - 2018 SN - 0889-7077 SP - 6-8 ST - Reducing opioid misuse among adolescents through physician education T2 - Substance Abuse TI - Reducing opioid misuse among adolescents through physician education UR - ://WOS:000452676700004 VL - 39 ID - 2043 ER - TY - JOUR AB - Background A scarcity of studies on the role of resilience resources (RRs) and vulnerability risk (VR) in children and adolescents with primary headache hampers the development of a risk-resilience model for pediatric headaches. Objective To examine the extent to which headache frequency and diagnosis are associated with RRs and VR and explore possible predictors of low RRs and high VR in a cross-sectional population-based study in adolescents. Methods This is a cross-sectional population study conducted in a small city in Brazil (Delfinopolis). Consents and analyzable data were obtained from 339/378 adolescents (89.7%). RRs and VR were assessed using the validated Brazilian version of the Resiliency Scales for Children and Adolescents, completed by the adolescents. Parents filled a structured questionnaire assessing sociodemographic and headache characteristics, as well as the Brazilian-validated version of the Strengths and Difficulties Questionnaire added to the impact supplement to evaluate the adolescent's psychosocial adjustment skills. Teachers completed a structured questionnaire about the students' school performance. Results A higher frequency of headache was associated with lower RRs (F-3,F-335 = 2.99, p = 0.031) and higher VR (F-3,F-335 = 4.05, p = 0.007). Headache diagnosis did not significantly influence the risk of having lower RRs or higher VR. In the exploratory analyses, females (OR 3.07; 95% CI: 1.16-9.3) and individuals with psychosocial adjustment problems (OR 7.5; 95% CI: 2.51-22.4) were predictors of low RRs, and prenatal exposure to tobacco (OR 5.6; 95% CI: 1.57-20.9) was a predictor of high VR in adolescents with primary headache. Conclusions The risk of low RRs and high VR was associated with a higher headache frequency, but not with headache diagnosis. These findings may contribute to the development of a risk-resilience model of headaches in the pediatric population and help identify novel targets and develop effective resources for successful interventions. AN - WOS:000628878000001 AU - Arruda, M. A. AU - Arruda, R. AU - Landeira-Fernandez, J. AU - Anunciacao, L. AU - Bigal, M. E. DA - Mar DO - 10.1111/head.14078 IS - 3 N1 - Arruda, Marco Antonio Arruda, Renato Landeira-Fernandez, J. Anunciacao, Luis Bigal, Marcelo Eduardo 1526-4610 PY - 2021 SN - 0017-8748 SP - 546-557 ST - Resilience and vulnerability in adolescents with primary headaches: A cross-sectional population-based study T2 - Headache TI - Resilience and vulnerability in adolescents with primary headaches: A cross-sectional population-based study UR - ://WOS:000628878000001 VL - 61 ID - 1749 ER - TY - JOUR AB - BACKGROUND: Nerve root decompression with instrumented spondylodesis is the most frequently performed surgical procedure in the treatment of patients with symptomatic low-grade spondylolytic spondylolisthesis. Nerve root decompression without instrumented fusion, i.e. Gill's procedure, is an alternative and less invasive approach. A comparative cost-effectiveness study has not been performed yet. We present the design of a randomised controlled trial on cost-effectiveness of decompression according to Gill versus instrumented spondylodesis. METHODS/DESIGN: All patients (age between 18 and 70 years) with sciatica or neurogenic claudication lasting more than 3 months due to spondylolytic spondylolisthesis grade I or II, are eligible for inclusion. Patients will be randomly allocated to nerve root decompression according to Gill, either unilateral or bilateral, or pedicle screw fixation with interbody fusion. The main primary outcome measure is the functional assessment of the patient measured with the Roland Disability Questionnaire for Sciatica at 12 weeks and 2 years. Other primary outcome measures are perceived recovery and intensity of leg pain and low back pain. The secondary outcome measures include, incidence of re-operations, complications, serum creatine phosphokinase, quality of life, medical consumption, costs, absenteeism, work perception, depression and anxiety, and treatment preference. The study is a randomised prospective multicenter trial in which two surgical techniques are compared in a parallel group design. Patients and research nurse will not be blinded during the follow-up period of 2 years. DISCUSSION: Currently, nerve root decompression with instrumented fusion is the golden standard in the surgical treatment of low-grade spondylolytic spondylolisthesis, although scientific proof justifying instrumented spondylodesis over simple decompression is lacking. This trial is designed to elucidate the controversy in best surgical treatment of symptomatic patients with low-grade spondylolytic spondylolisthesis. AD - Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands. m.arts@mchaaglanden.nl AN - 18822175 AU - Arts, M. P. AU - Verstegen, M. J. AU - Brand, R. AU - Koes, B. W. AU - van den Akker, M. E. AU - Peul, W. C. C2 - PMC2570682 DA - Sep 28 DO - 10.1186/1471-2474-9-128 DP - NLM ET - 2008/09/30 KW - Adolescent Adult Aged Bone Screws Cost-Benefit Analysis Creatine Kinase/blood Decompression, Surgical/adverse effects/*economics/methods Depression Female Health Care Costs Humans Male Middle Aged Outcome Assessment, Health Care Patient Satisfaction Prospective Studies Quality of Life Sciatica/economics/*etiology/*surgery Spinal Fusion/adverse effects/*economics/methods Spondylolisthesis/*complications Young Adult LA - eng N1 - 1471-2474 Arts, Mark P Verstegen, Marco J T Brand, Ronald Koes, Bart W van den Akker, M Elske Peul, Wilco C Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't BMC Musculoskelet Disord. 2008 Sep 28;9:128. doi: 10.1186/1471-2474-9-128. PY - 2008 SN - 1471-2474 SP - 128 ST - Cost-effectiveness of decompression according to Gill versus instrumented spondylodesis in the treatment of sciatica due to low grade spondylolytic spondylolisthesis: a prospective randomised controlled trial [NTR1300] T2 - BMC Musculoskelet Disord TI - Cost-effectiveness of decompression according to Gill versus instrumented spondylodesis in the treatment of sciatica due to low grade spondylolytic spondylolisthesis: a prospective randomised controlled trial [NTR1300] VL - 9 ID - 3778 ER - TY - JOUR AB - Next to headache recurrent gastro-intestinal complaints constitute the most common reason for medical consultation among daycare and school children. The use of more sophisticated examination methods has shown that in up to 50 per cent of cases the cause of the gastric complaints is a treatable disease or a functional anomaly of the gastro-intestinal tract. The commonest conditions are lactose intolerance, gluten sensitivity, gastro-oesophageal reflux, and gastritis. In some cases stomach pain is triggered by psychosomatic mechanisms. Depending upon the child's age, aetiological indications can sometimes be derived from history taking. In many cases the investigations can be made in the out-patient clinic. The cornerstones of treatment are various kinds of dietary elimination regimens, prokinetic agents, and antibiotics. Recently, the investigation of neuroendocrinological and neurophysiological processes related to psychosomatic causes of gastric complaints has once again become common. AD - Kliniken för barnsjukdomar, Tammerfors universitetssjukhus, Tammerfors universitet. AN - 9497614 AU - Ashorn, M. DA - Feb DP - NLM ET - 1998/03/14 IS - 2 KW - Abdominal Pain/*etiology/physiopathology/psychology Child Child, Preschool Diet Female Gastrointestinal Diseases/diagnosis/*physiopathology Humans Male Psychophysiologic Disorders/diagnosis/psychology Recurrence Stomach Diseases/diagnosis/*physiopathology/psychology LA - swe N1 - Ashorn, M English Abstract Journal Article Sweden Nord Med. 1998 Feb;113(2):43-5, 59. OP - Recidiverande magbesvär hos barn. PY - 1998 SN - 0029-1420 (Print) 0029-1420 SP - 43-5, 59 ST - [Recurrent stomach complaints in children] T2 - Nord Med TI - [Recurrent stomach complaints in children] VL - 113 ID - 3517 ER - TY - JOUR AB - OBJECTIVE: Inflammatory bowel disease (IBD) and functional abdominal pain (FAP) are associated with debilitating symptoms and frequent medical visits that may disrupt school functioning. The aim of this study was to assess school-related quality of life and school absenteeism in children with IBD, compared with FAP and healthy controls. METHODS: School absenteeism and participation in school and after-school activities data were obtained for 43 children with Crohn disease (CD), 31 children with ulcerative colitis (UC), 42 children with FAP, and 30 age-matched healthy controls for the 2013-2014 school year. We used a semistructured questionnaire for both children and parents. For diminishing recall bias, absenteeism data were cross-matched with the patient's school annual report cards. RESULTS: Children with FAP, CD, and UC missed significantly more school days than age-matched healthy controls (17.6 [8.75-30], 24 [14-30], and 21 [12-25] vs 5.1 [3.75-6.25], respectively, P < 0.001). Compared with children with FAP, absenteeism because of medical appointments and hospitalization was significantly greater in children with CD and UC (8.8 [4-14] and 7.1 [3-10] vs 4.4 [2-6.25], P = 0.001). Participation of children with FAP and IBD in various school and after-school activities was significantly reduced compared with healthy controls. There was no difference in school attendance and functioning between children with IBD and FAP. CONCLUSIONS: FAP has a significant impact on school attendance and functioning similar to IBD. These findings show that significant psychosocial and academic difficulties are faced not only by children with chronic diseases like IBD but also by children with FAP. AU - Assa, Amit AU - Ish-Tov, Alona AU - Rinawi, Firas AU - Shamir, Raanan DA - 2015/11// DO - 10.1097/MPG.0000000000000850 DP - PubMed IS - 5 J2 - J Pediatr Gastroenterol Nutr KW - Abdominal Pain Absenteeism Adolescent Child Chronic Disease Colitis, Ulcerative Crohn Disease Female Humans Male Parents Quality of Life Schools Surveys and Questionnaires LA - eng PY - 2015 SN - 1536-4801 SP - 553-557 ST - School Attendance in Children With Functional Abdominal Pain and Inflammatory Bowel Diseases T2 - Journal of Pediatric Gastroenterology and Nutrition TI - School Attendance in Children With Functional Abdominal Pain and Inflammatory Bowel Diseases UR - http://www.ncbi.nlm.nih.gov/pubmed/25950089 VL - 61 ID - 83 ER - TY - JOUR AB - Objective: To identify differences in repositioning error in adolescents with and without non-specific chronic low back pain (NSCLBP), sub-groups of NSCLBP and in different spinal regions. Methods: Spinal repositioning error was measured during a seated task. Variables were constant error (CE), absolute error (AE) and variable error (VE) for lower lumbar, upper lumbar and lumbar angles. 28 subjects with NSCLBP were sub-classified using O'Sullivans system and compared to 28 healthy controls. Results: Significant differences were noted for AE between adolescents with and without NSCLBP, but no differences were found for CE or VE. When sub-grouped there was a pattern for lower AE and higher VE in the flexion sub-group. This group also displayed a tendency to undershoot the criterion position in the lower lumbar spine. Greater VE was noted in the extension sub-group and those with no NSCLBP in the upper lumbar compared to the lower lumbar spine. Conclusions: Differences in spinal repositioning errors were noted between adolescents with and without NSCLBP and sub-groups of NSCLBP. Those with flexion-pattern NSCLBP had the lowest levels of spinal repositioning ability. Individuals with no-LBP (low-back pain) or extension-pattern NSCLBP displayed greater variability in the upper lumbar spine. (C) 2013 Elsevier Ltd. All rights reserved. AN - WOS:000324341300010 AU - Astfalck, R. G. AU - O'Sullivan, P. B. AU - Smith, A. J. AU - Straker, L. M. AU - Burnett, A. F. DA - Oct DO - 10.1016/j.math.2013.02.005 IS - 5 N1 - Astfalck, Roslyn G. O'Sullivan, Peter B. Smith, Anne J. Straker, Leon M. Burnett, Angus F. Study, Raine/K-4517-2013; Study, Raine/G-9547-2015; /B-2407-2013 /0000-0002-7786-4128; O'Sullivan, Peter/0000-0002-3982-4088 PY - 2013 SN - 1356-689X SP - 410-417 ST - Lumbar spine repositioning sense in adolescents with and without non-specific chronic low back pain - An analysis based on sub-classification and spinal regions T2 - Manual Therapy TI - Lumbar spine repositioning sense in adolescents with and without non-specific chronic low back pain - An analysis based on sub-classification and spinal regions UR - ://WOS:000324341300010 VL - 18 ID - 2347 ER - TY - JOUR AB - BACKGROUND: Regular physical activity (PA) of moderate intensity, has significant benefits for health. To our knowledge, no previous studies have examined the prevalence of low back pain (LBP) in a Bosnia and Herzegovina. The goal of this study is to present the data on prevalence of low back pain (LBP) in young adults and its association with PAPA. METHODS: Six months prevalence were assessed using questionnaire for grading pain, and graded back pain was determined using the Chronic Pain Scale (CPS). The CPS is a multidimensional measure that assesses 2 dimensions of overall chronic pain severity: pain intensity and pain-related disability. The study sample presented (N.=330) female students and (N.=213) male students. RESULTLTS: 78.5% of all students suffered pains at some point over the past six months. Female students reported higher prevalence of LBP 82.4%, compared to the male students 72.3%. The average value of pain intesity in the past 6 months in women is 2.80 and 2.31 in men on a numerical scale from 0 to 10. Females had higher intensity and disability scores. CONCLUSIONS: The key importance is the fact that the population of students needs to be offered such PAPA that will not include vigorous activities. AN - WOS:000400412600001 AU - Atikovic, A. AU - Pavletic, M. S. AU - Kalinski, S. D. AU - Bilalic, J. AU - Kurt, A. DA - May DO - 10.23736/s0393-3660.16.03371-4 IS - 5 N1 - Atikovic, Almir Pavletic, Mitija S. Kalinski, Suncica D. Bilalic, Jasmin Kurt, Almir Kalinski, Suncica D/H-2808-2015; Kalinski, Suncica Delas/AAN-2806-2021; Atikovic, Almir/AAK-9816-2020 Kalinski, Suncica D/0000-0002-0833-6719; Atikovic, Almir/0000-0002-3395-5044 1827-1812 PY - 2017 SN - 0393-3660 SP - 229-236 ST - Prevalence and risk factors of low back pain among undergraduate students in Bosnia and Herzegovina T2 - Gazzetta Medica Italiana Archivio Per Le Scienze Mediche TI - Prevalence and risk factors of low back pain among undergraduate students in Bosnia and Herzegovina UR - ://WOS:000400412600001 VL - 176 ID - 2099 ER - TY - JOUR AB - Background: Refractive errors are common eye disorders and are leading causes of visual impairment in the general population. Children with uncorrected refractive error may experience reduced visual acuity, transient blurring, headache and persistent ocular discomforts particularly for close work which can impair reading efficiency and school performance. Aim: This article documents the prevalence of refractive errors in school-age children of different ethnic origins. The goal is to identify possible variation in measuring techniques and diagnostic criteria, as well as limitations of studies, to provide a clear direction for future studies. Methods: The review was undertaken through a detailed evaluation of peer-reviewed publications of primary research on this topic. The keywords for the search included 'refractive error', 'hyperopia', 'myopia', 'astigmatism' and 'school children'. Only epidemiological studies with participants between 5 and 18 years of age were included. Results: Although several population and school-based studies have been conducted in various racial groups and populations, their findings were diverse owing to inconsistencies in the methods applied in identifying children in need of refraction, measurement techniques and diagnostic criteria for refractive errors. There are also some limitations associated with the sampling design and characteristics, which may have influenced the outcome measures. Conclusion: Despite the problems inherent in the studies, the review indicates that refractive error in school-age children is a public health concern in those populations and warrants additional research that will provide reliable data for proper planning of intervention strategies. AN - WOS:000468533000001 AU - Atowa, U. C. AU - Hansraj, R. AU - Wajuihian, S. O. C7 - a461 DA - May DO - 10.4102/aveh.v78i1.461 IS - 1 N1 - Atowa, Uchenna C. Hansraj, Rekha Wajuihian, Samuel O. Hansraj, Rekha/U-7747-2019 Atowa, Uchenna Chigozirim/0000-0002-5188-2678; WAJUIHIAN, SAM/0000-0002-6875-8788; Hansraj, Rekha/0000-0003-1487-6380 2410-3039 PY - 2019 SN - 0378-9411 ST - Vision problems: A review of prevalence studies on refractive errors in school-age children T2 - African Vision and Eye Health Journal TI - Vision problems: A review of prevalence studies on refractive errors in school-age children UR - ://WOS:000468533000001 VL - 78 ID - 1921 ER - TY - JOUR AB - The purpose of this study was to investigate the effectiveness of Acceptance and Commitment Therapy (ACT) based psycho-educational group on test anxiety of high school students. The participants were six senior high school students with high level of test anxiety and all of the participants were female. They were selected by multi-stage sampling method. Psycho-educational group was designed to include six processes of psychological flexibility/inflexibility, that is the core concept of ACT; and it lasted six weeks by 90 minutes per week. Participants were interviewed before and after the psychoeducation group. The content analysis was applied and the findings of ACT-based psychoeducation program revealed that participants' test anxiety and psychological inflexibility level as well as how they handle the problem have changed as a result of this psycho-educational group process. The participants also stated that their definition of test anxiety problem have changed after the group process. Implications and suggestions for future research and practice were discussed. AN - WOS:000565232500009 AU - Aydin, Y. AU - Aydin, G. DA - Sep DO - 10.9779/pauefd.584565 IS - 50 N1 - Aydin, Yasin Aydin, Gokcen Aydin, Gokcen/AAA-2394-2021 1309-0275 PY - 2020 SN - 1301-0085 SP - 180-200 ST - Acceptance and Commitment Therapy Based Psychoeducation Group for Test Anxiety: A Case Study of Senior High School Students T2 - Pamukkale Universitesi Egitim Fakultesi Dergisi-Pamukkale University Journal of Education TI - Acceptance and Commitment Therapy Based Psychoeducation Group for Test Anxiety: A Case Study of Senior High School Students UR - ://WOS:000565232500009 ID - 1801 ER - TY - JOUR AB - Abdominal pain is a common reason for medical visits. We examined the prevalence, gastrointestinal, and emotional significance of abdominal pain in a population-based cohort serially followed up from birth to 17 years. Children and adolescents from Generation 2 of the Raine Study participated in comprehensive cross-sectional assessments at ages 2, 5, 8, 10, 14 and 17 years. At 17 years, medical history, general health, gastrointestinal symptoms, medications, health practitioner attendance, and self-rated unhappiness were recorded. Longitudinal data regarding abdominal pain or unhappiness, from serial questionnaires, were analysed to identify factors associated with abdominal pain and adverse emotional health at age 17 years. Females experienced more abdominal pain than males at all ages (p < 0.05). Seventeen-year-old adolescents with abdominal pain reported a higher prevalence of depression, anxiety, being bullied at school, and poorer health status than those without abdominal pain (p < 0.05 for all). Abdominal pain and unhappiness during childhood and mid-adolescence were prospectively associated with recurrent abdominal pain, anxiety, depression and unhappiness during late adolescence (p < 0.05 for all). In conclusion, abdominal pain in children and adolescents associates with depression, anxiety, being bullied, unhappiness and reduced overall health-rating during adolescence. Awareness of these factors may guide management decisions. AN - WOS:000562806900007 AU - Ayonrinde, O. T. AU - Ayonrinde, O. A. AU - Adams, L. A. AU - Sanfilippo, F. M. AU - O'Sullivan, T. A. AU - Robinson, M. AU - Oddy, W. H. AU - Olynyk, J. K. C7 - 1646 DA - Feb DO - 10.1038/s41598-020-58543-0 IS - 1 N1 - Ayonrinde, Oyekoya T. Ayonrinde, Oyedeji A. Adams, Leon A. Sanfilippo, Frank M. O'Sullivan, Therese A. Robinson, Monique Oddy, Wendy H. Olynyk, John K. Ayonrinde, Oyekoya/K-2337-2019; Sanfilippo, Frank/H-9334-2013 Ayonrinde, Oyekoya/0000-0002-0598-151X; Olynyk, John/0000-0003-0417-3411; Ayonrinde, Oyedeji/0000-0002-8799-4225; Robinson, Monique/0000-0001-8834-6089; Sanfilippo, Frank/0000-0003-3639-0787 PY - 2020 SN - 2045-2322 ST - The relationship between abdominal pain and emotional wellbeing in children and adolescents in the Raine Study T2 - Scientific Reports TI - The relationship between abdominal pain and emotional wellbeing in children and adolescents in the Raine Study UR - ://WOS:000562806900007 VL - 10 ID - 1840 ER - TY - JOUR AB - Fourteen patients or their immediate family were interviewed about their experiences of having either unilateral or bilateral external distraction osteogenesis of the mandible. The patients showed a high level of co-operation with treatment. Six of the 14 patients required repeat distractions, and had been informed and accepted that this was a possibility before the initial distraction. However, patients or their parents expressed some reservations about the extraoral distractors, which prevented them from practising their favourite sport and made them vulnerable to bullying by their friends and colleagues. Patients had moderate pain when the appliances were removed. They all expressed their satisfaction with the results and would recommend this treatment to others. Problems, including speech, eating, pain, and sleeping difficulties, were encountered by patients at all stages of treatment. Of considerable concern was the disruption of education when the child was treated during the school term. (C) 2002 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Science Ltd. All rights reserved. AN - WOS:000179138700006 AU - Ayoub, A. F. AU - Duncan, C. M. AU - McLean, G. R. AU - Moos, K. F. AU - Chibbaro, P. D. DA - Oct DO - 10.1016/s0266-4356(02)00191-2 IS - 5 N1 - Ayoub, AF Duncan, CM McLean, GR Moos, KF Chibbaro, PD Ayoub, Ashraf/0000-0002-2760-6008 1532-1940 PY - 2002 SN - 0266-4356 SP - 397-405 ST - Response of patients and families to lengthening of the facial bones by extraoral distraction osteogenesis: a review of 14 patients T2 - British Journal of Oral & Maxillofacial Surgery TI - Response of patients and families to lengthening of the facial bones by extraoral distraction osteogenesis: a review of 14 patients UR - ://WOS:000179138700006 VL - 40 ID - 2820 ER - TY - JOUR AB - The frequency and significance of headache in children and adolescent has been drawing more attention nowadays. Similarly, growing body of data is being collected on the quality of life of headache in children and adolescent to which increased attention is paid. Compared with other chronic disorders, headache in children has more negative effect on school performance, as well as emotional status. As for school children, it is reported that these children could not go to school on a regular basis, they do less performance and their careers are negatively affected on the long-term. Accompanying symptoms such as depression, somatization, anxiety also impairs the quality of life. Early identification and treatment of headache will not only improve a health condition, but also will provide advancement in academic and social area as well as psychological development for children with headache. AN - WOS:000389744200021 AU - Ayta, S. AU - Uluduz, D. AU - Poyraz Findik, O. T. AU - Ozge, A. IS - 1 N1 - Ayta, Semih Uluduz, Derya Poyraz Findik, Onur Tugce Ozge, Aynur Findik, Onur Tugce Poyraz/Y-4044-2018 Findik, Onur Tugce Poyraz/0000-0002-2376-7592 PY - 2016 SN - 1302-1664 SP - 185-193 ST - Quality of Life in Children and Adolescents With Primary Headache Disorders T2 - Journal of Neurological Sciences-Turkish TI - Quality of Life in Children and Adolescents With Primary Headache Disorders UR - ://WOS:000389744200021 VL - 33 ID - 2191 ER - TY - JOUR AB - Objective: We aimed to detailly investigate the effects of in school, after school academic activities and hobbies on the frequencies and properties of headache, in high academic expectation school group. Methods: The study was carried out among the all students in a high school in Mersin, Turkey. They were all given a standard questionnaire that consisted of the questions regarding the demographics, presence or absence of headache, if yes detailed characteristics questioned, the after school activities, percentage of their happiness and an international scale for the establishment of daily life routines, the MIDAS. esults: 611 subjects (70.4 % of the total population) were selected to be enrolled for evaluation. The groups were even and were well capable of representing the community. 134 (21.9%) had no headache at all. 278 subjects (45.5%) had TTH and 175 (28.6%) of the participants had migraine. The MIDAS scores were highest in the group who had migraine with aura (p<0.001). The proposed cut-off values of study/hobbies time in a week are calculated to be 5.54 +/- 0.32 hours for headache disorders (in general), 6.12 +/- 0.57 hours for migraine and 5.23 +/- 0.39 hours for TTH. Conclusion: This study demonstrates that headache is a commonly encountered problem among the young adults that raises problems both in their academic and social lives. If this problem is kept unresolved, these young adults that represent the highest academic group among the com-munity carry the risk forming an unhealthy society in terms of both academic and social life in the future. AN - WOS:000300363200003 AU - Aytacoglu, H. AU - Ozge, A. AU - Kostekci, I. AU - Tasdelen, B. AU - Oksuz, N. AU - Toros, F. IS - 4 N1 - Aytacoglu, Hakan Ozge, Aynur Kostekci, Ilknur Tasdelen, Bahar Oksuz, Nevra Toros, Fevziye Oksuz, Nevra/AAH-7476-2019; Tasdelen, Bahar/G-4291-2015 Tasdelen, Bahar/0000-0001-8146-4912 PY - 2011 SN - 1302-1664 SP - 453-464 ST - The Effects of Daily Variables on Primary Headache Disorders in High-School Children; A Proposal For A Cut-off Value For Study/Leisure Time Regarding Headache Types T2 - Journal of Neurological Sciences-Turkish TI - The Effects of Daily Variables on Primary Headache Disorders in High-School Children; A Proposal For A Cut-off Value For Study/Leisure Time Regarding Headache Types UR - ://WOS:000300363200003 VL - 28 ID - 2520 ER - TY - JOUR AB - Background: Cancer affects not only the patient but also their entire family, especially adolescents. Adolescents whose parents are ill may manifest their distress through changes in school performance, physical complaints of pain and discomfort, as well as changes in social and interpersonal relations. There has been very little research about the effects of cancer on adolescents in Iran. Objectives:The purpose of this qualitative study was to explore the Iranian adolescents' experiences when living with a parent with cancer. Patients and Methods: In this research, the descriptive-explorative approach was used. There were a total of 27 participants. Purposeful sampling was used and data collection methods were semi-structured deep interviews. Constant comparative analysis was used to study the data. Results: The findings of this study showed that the main experiences of these adolescents were categorized into seven themes: 1 psychological problems of adolescents; 2-supportive-educative needs; 3- cancer as a two edged sword in family relationships; 4- stages of confrontation with the parent's cancer; 5- effect of cancer on social dimensions; 6- affective and helpful supportive agents; 7- Need of support for education under special conditions. Conclusions: This research showed that Iranian adolescents had the same experiences as other adolescents in other countries in many aspects yet in some issues, such as religious strategy they had strong religious beliefs that would help them cope with their parents' cancer. Also it was shown that we must plan a program in which education and support should be provided to enable adolescents to cope with this detrimental situation with minimal disruption. AN - WOS:000375221700014 AU - Azarbarzin, M. AU - Malekian, A. AU - Taleghani, F. C7 - e26410 DA - Jan DO - 10.5812/ircmj.26410 IS - 1 N1 - Azarbarzin, Mehrdad Malekian, Azadeh Taleghani, Fariba Azarbarzin, Mehrdad/Q-5887-2017 Azarbarzin, Mehrdad/0000-0002-8824-8515 2074-1812 PY - 2016 SN - 2074-1804 ST - Adolescents' Experiences When Living With a Parent With Cancer: A Qualitative Study T2 - Iranian Red Crescent Medical Journal TI - Adolescents' Experiences When Living With a Parent With Cancer: A Qualitative Study UR - ://WOS:000375221700014 VL - 18 ID - 2199 ER - TY - JOUR AB - Study Objective: The study sought to gain an in-depth understanding of primary dysmenorrhea management and coping strategies for dysmenorrhea among adolescents and young adults who were in school. Design: The study adopted a qualitative exploratory approach using a descriptive phenomenology to explore the phenomenon of interest. Setting: The study was conducted in two educational institutions in Accra, Ghana: a Senior High School (SHS) and a University. Participants and Data Collection: Sixteen participants were purposively recruited (8 SHS and 8 University students) through snowball sampling. Individual interviews were conducted in English, audio-taped, transcribed and analysed using content analysis procedures. Informed consent was obtained from all participants and rigor was ensured through prolonged engagement and member checking. Results: Participants employed both pharmacologic (orthodox and herbal) and nonpharmacologic approaches such as warm compress, exercise, and water and diet therapy for their dysmenorrhea. Students' dysmenorrhea was managed at the school clinic and the hospital. Health professionals demonstrated negative attitudes towards dysmenorrhea management. Students coped with dysmenorrhea by planning activities before the onset of pain, receiving social and spiritual support, and developing a mind-set to bear pain. Conclusions: Individualized approaches should be employed to enhance dysmenorrhea management. Health professionals should be educated on dysmenorrhea to improve their attitude and skills for dysmenorrhea management. AN - WOS:000356119500009 AU - Aziato, L. AU - Dedey, F. AU - Clegg-Lamptey, J. N. A. DA - Jun DO - 10.1016/j.jpag.2014.07.002 IS - 3 N1 - Aziato, Lydia Dedey, Florence Clegg-Lamptey, Joe Nat A. 1873-4332 PY - 2015 SN - 1083-3188 SP - 163-169 ST - Dysmenorrhea Management and Coping among Students in Ghana: A Qualitative Exploration T2 - Journal of Pediatric and Adolescent Gynecology TI - Dysmenorrhea Management and Coping among Students in Ghana: A Qualitative Exploration UR - ://WOS:000356119500009 VL - 28 ID - 2235 ER - TY - JOUR AB - BACKGROUND: Treatment procedures are the most common sources of pain in children. Children with chronic diseases such as thalassemia experience many pains during painful procedures including at times of diagnosis, treatment and control of their disease. Several methods have been reported to reduce pain. Clinical professionals usually use distraction techniques to reduce pain. However, there is no agreement between them that which distraction technique is better for reducing pain. The aim of this study was omparing the effects of regular breathing exercise and making bubbles on the pain of catheter insertion in school age children. METHODS: This was a clinical trial on 60 children in the age range of 6 to 12 years, who were suffering from thalassemia and had a file in the Center for Thalassemia. Participants were randomly divided into two groups of experiment and control. Bubble making was performed for the first group and regular breathing exercise was performed for the second group. Data were collected using a demographic questionnaire, a scale for pediatric pain behavioral symptoms and Numeric Pain Rating Scale. Data were analyzed using descriptive (frequency, mean and standard deviation) and inferential statistics (ANOVA, Kruskal Wallis, and Mann Whitney U tests and Spearman correlation). RESULTS: The mean pain score based on the numerical scale was 5.60 ± 3.13 in the control group, 1.60 ± 1.75 in the bubble-making group and 1.85 ± 1.42 in the breathing exercise group. The mean score of behavioral pain symptoms was 3.80 ± 2.80 in the control group, 1.15 ± 1.13 in the bubble-making group, and 0.96 ± 0.75 in the breathing exercise group. Results showed a significant difference in the mean pain scores (based on numeric scale and pain behavior scale) between the control group and other groups after the injection, but the difference in the mean pain scores between the two groups of experiment after the injection was not significant. CONCLUSIONS: According to the results of this study, both distraction methods of regular breathing exercise and bubble-making can reduce the pain of catheter insertion in children and since there was no difference between their effects, they can be used based on the individual child's interest. AU - Bagheriyan, Samaneh AU - Borhani, Fariba AU - Abbaszadeh, Abbas AU - Ranjbar, Hadi DA - 2011 DP - PubMed IS - 2 J2 - Iran J Nurs Midwifery Res KW - distraction Pain school-age children thalassemia LA - eng PY - 2011 SN - 2228-5504 SP - 174-180 ST - The effects of regular breathing exercise and making bubbles on the pain of catheter insertion in school age children T2 - Iranian Journal of Nursing and Midwifery Research TI - The effects of regular breathing exercise and making bubbles on the pain of catheter insertion in school age children UR - http://www.ncbi.nlm.nih.gov/pubmed/22224103 VL - 16 ID - 98 ER - TY - JOUR AB - Background: Suicide among adolescents in the United States is the second leading cause of death. Bullying victimization has also been identified as a growing public health concern. Although studies have examined the association between bullying victimization and mental health outcomes, there is a dearth of research investigating the association between bullying victimization and suicidal ideation among adolescents. Objective: The objective of this study is to investigate the association between bullying victimization and suicidal ideation among adolescents. Participants and Setting: Data for this study came from the 2017 National Youth Risk Behavior Survey. Methods: An analytic sample of 14,603 adolescents aged 14-18 years (52 % female) was analyzed using binary logistic regression. Results: About 18 % of adolescents experienced suicidal ideation during the past 12 months. About one in ten adolescents (9.1 %) were victims of both school bullying and cyberbullying. Bullying victimization was associated with suicidal ideation whereby, adolescents who experienced both school bullying and cyberbullying victimization had 3.26 times higher odds of experiencing suicidal ideation (AOR = 3.26, p < .001, 95 % CI = 3.10-3.43), adolescents who experienced school bullying victimization had 2.15 times higher odds of experiencing suicidal ideation (AOR = 2.15, p < .001, 95 % CI = 2.04-2.27), and adolescents who experienced cyberbullying victimization had twice the odds of experiencing suicidal ideation (AOR = 2.00, p < .001, 95 % CI =1.87-2.14). Other factors significantly associated with suicidal ideation include forced sexual intercourse, depressive symptoms, cigarette smoking, alcohol use, cannabis use, and illicit drug use. Conclusion: Understanding the association between bullying victimization and suicidal ideation could contribute to early identification of adolescents who may be at risk for suicide. AN - WOS:000520951800016 AU - Baiden, P. AU - Tadeo, S. K. C7 - 104417 DA - Apr DO - 10.1016/j.chiabu.2020.104417 N1 - Baiden, Philip Tadeo, Savarra K. Tadeo, Savarra/AAA-1007-2021 Baiden, Philip/0000-0003-3877-2594 1873-7757 PY - 2020 SN - 0145-2134 ST - Investigating the association between bullying victimization and suicidal ideation among adolescents: Evidence from the 2017 Youth Risk Behavior Survey T2 - Child Abuse & Neglect TI - Investigating the association between bullying victimization and suicidal ideation among adolescents: Evidence from the 2017 Youth Risk Behavior Survey UR - ://WOS:000520951800016 VL - 102 ID - 1833 ER - TY - JOUR AB - Migraine involves 5-10% of children and adolescents. Thirty percent of children with severe migraine attacks have school absence and reduced quality of life that need preventive therapy. The purpose of this randomised control trial study is to compare the effectiveness, safety and the tolerability of pregabalin toward Propranolol in migraine prophylaxis of children. From May 2011 to October 2012, 99 children 3-15 years referred to the neurology clinic of Mofid Children's Hospital with a diagnosis of migraine enrolled the study. Patients randomly divided into two groups (A&B). We treated children of group A with capsule of pregabalin as children of group B with tablet of propranolol for at least 8 weeks. In this study, 99 patients were examined that 91 children reached the last stage. The group A consistsed of 46 patients, 12(26.1%) girls, 34 (73.9%) boys and the group B consisted of 45 patients, 14(31.1%) girls, 31 (68.9%) boys. Basis of age, gender, headache onset, headache frequency, migraine type, triggering and relieving factors there was no significant difference among these groups (P>0.05). After 4 and 8 weeks of Pregabalin usage monthly headache frequency decreased to 2.2±4.5 and 1.76±6.2 respectively. Propranolol reduced monthly headache frequency up to 3.73±6.11 and 3.34±5.95 later 4 and 8 weeks respectively. There was a significant difference between these two groups according to headache frequency reduction (P=0.04). Pregabalin efficacy in reducing the frequency and duration of pediatric migraine headache is considerable in comparison with propranolol. AD - Bahrami Children Hospital, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran. Dr.mkbakhshandehbali@yahoo.com. Department of Community Medicine, Research Development Center of Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Dr.mkbakhshandehbali@yahoo.com. Department of Pediatrics, Kermanshah University of Medical Sciences, Kermanshah, Iran. Dr.mkbakhshandehbali@yahoo.com. Department of Pediatric Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Dr.mkbakhshandehbali@yahoo.com. AN - 26024701 AU - Bakhshandeh Bali, M. AU - Rahbarimanesh, A. A. AU - Sadeghi, M. AU - Sedighi, M. AU - Karimzadeh, P. AU - Ghofrani, M. DP - NLM ET - 2015/05/31 IS - 5 KW - Adolescent Child Child, Preschool Female Humans Male Migraine Disorders/*prevention & control Pregabalin/*therapeutic use Propranolol/*therapeutic use *Quality of Life LA - eng N1 - 1735-9694 Bakhshandeh Bali, MohammadKazem Rahbarimanesh, Ali Akbar Sadeghi, Manelie Sedighi, Mostafa Karimzadeh, Parvaneh Ghofrani, Mohammad Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Iran Acta Med Iran. 2015;53(5):276-80. PY - 2015 SN - 0044-6025 SP - 276-80 ST - Comparison of propranolol and pregabalin for prophylaxis of childhood migraine: a randomised controlled trial T2 - Acta Med Iran TI - Comparison of propranolol and pregabalin for prophylaxis of childhood migraine: a randomised controlled trial VL - 53 ID - 3473 ER - TY - JOUR AB - AIM: To determine the prevalence of recurrent complaints of pain (RCP) in Greek children, and to examine associations with socio-demographic characteristics and psychosocial factors. METHODS: Cross-sectional study comprising a nationally representative population of 8130 7-y-old Greek schoolchildren. Data were collected by mailed questionnaires (response rate 89%). RCP was defined as present if at least one of the complaints of headache, abdominal pain or limb pain occurred at least once a week. RESULTS: The RCP prevalence rate was 7.2%, with significant gender differences (8.8% of girls, 5.7% of boys; p<0.001). RCP was significantly positively associated with a chronic health problem among the children, frequent change of residence, poor school performance, often watching TV and rarely playing with other children. There were no statistically significant associations of RCP with family structure and socio-economic status. CONCLUSION: The results are indicative of the prevalence of RCP in Greek schoolchildren. This study enlightens the psychosocial component of RCP and emphasizes the importance of gathering information on children's social background in medical settings. AD - First Department of Paediatrics, Aghia Sofia Children's Hospital, Athens, Greece. AN - 16882567 AU - Bakoula, C. AU - Kapi, A. AU - Veltsista, A. AU - Kavadias, G. AU - Kolaitis, G. DA - Aug DO - 10.1080/08035250600684453 DP - NLM ET - 2006/08/03 IS - 8 KW - Child Cross-Sectional Studies Female Greece/epidemiology Health Status Health Surveys Humans Life Style Male Pain/*epidemiology/psychology Prevalence Recurrence Residence Characteristics Risk Factors Sex Distribution Socioeconomic Factors LA - eng N1 - Bakoula, Chryssa Kapi, Aikaterini Veltsista, Alexandra Kavadias, George Kolaitis, Gerasimos Journal Article Norway Acta Paediatr. 2006 Aug;95(8):947-51. doi: 10.1080/08035250600684453. PY - 2006 SN - 0803-5253 (Print) 0803-5253 SP - 947-51 ST - Prevalence of recurrent complaints of pain among Greek schoolchildren and associated factors: a population-based study T2 - Acta Paediatr TI - Prevalence of recurrent complaints of pain among Greek schoolchildren and associated factors: a population-based study VL - 95 ID - 3544 ER - TY - JOUR AB - Objectives: Suicide is a leading cause of death; unfortunately most individuals at risk for suicide are not identified, assessed or treated by the mental health system. Investigating medical healthcare utilization among individuals with a history of suicide attempt may identify alternative settings for case finding and brief intervention. Methods: The study sample (n=1422, 58% female, 72% African-American) is from a prospective cohort of adults (27-31 years) who participated in a randomized trial of school-based interventions. Logistic regression evaluated the relationship between lifetime history of suicide attempt with past year medical service utilization and selected self-reported health conditions, controlling for lifetime Major Depressive Disorder (MDD), demographic factors, health insurance status and employment. Results: A suicide attempt history was associated with past year emergency department medical visits [aOR 1.51, 95% CI 1.04-2.18, P=.03], but not primary care visits or inpatient hospitalization, when controlling for MDD and other covariates. Severe headaches and chronic gastrointestinal conditions were also associated with lifetime suicide attempt [aOR 1.50, 95% CI 1.03-2.17 and aOR 1.67, 95% CI 1.06-2.63, respectively]. Conclusions: Suicide prevention, including universal screening and brief intervention, is indicated in emergency department settings. Restricting screening to subgroups, such as those individuals presenting with depression, may miss at-risk individuals with somatic concerns. (C) 2014 Elsevier Inc. All rights reserved. AN - WOS:000339333800015 AU - Ballard, E. D. AU - Cwik, M. AU - Storr, C. L. AU - Goldstein, M. AU - Eaton, W. W. AU - Wilcox, H. C. DA - Jul-Aug DO - 10.1016/j.genhosppsych.2014.03.004 IS - 4 N1 - Ballard, Elizabeth D. Cwik, Mary Storr, Carla L. Goldstein, Mitchell Eaton, William W. Wilcox, Holly C. Ballard, Elizabeth/O-6856-2017 Ballard, Elizabeth/0000-0001-5304-0127; Wilcox, Holly/0000-0003-2624-0654 1873-7714 PY - 2014 SN - 0163-8343 SP - 437-441 ST - Recent medical service utilization and health conditions associated with a history of suicide attempts T2 - General Hospital Psychiatry TI - Recent medical service utilization and health conditions associated with a history of suicide attempts UR - ://WOS:000339333800015 VL - 36 ID - 2299 ER - TY - JOUR AB - Considerable heterogeneity among pediatric chronic pain patients may at least partially explain the variability seen in the response to behavioral therapies. The current study tested whether autistic traits and attention-deficit/hyperactivity disorder (ADHD) symptoms in a clinical sample of children and adolescents with chronic pain are associated with socioemotional and functional impairments and response to acceptance and commitment therapy (ACT) treatment, which has increased psychological flexibility as its core target for coping with pain and pain-related distress. Children and adolescents aged 8-18 years (N = 47) were recruited. Patients and their parents completed questionnaires pre- and post-ACT of 17 sessions. Correlational analyses and mixed-effects models were used to assess the role of autistic traits and ADHD symptoms in pretreatment functioning and ACT-treatment response. Outcome variables were degree to which pain interfered with daily activities (i.e., pain interference, sleep, and physical and school functioning), socioemotional functioning (i.e., depressive symptoms, emotional, and social functioning), psychological inflexibility, and pain intensity. Autistic traits and ADHD symptoms, pain frequency, and pain duration were measured at pretreatment only. Higher autistic traits were associated with greater pain interference, higher depression, and greater psychological inflexibility. Higher ADHD symptomatology was associated with greater pretreatment pain interference, lower emotional functioning, greater depression, and longer duration of pain. Across patients, all outcome variables, except for sleep disturbances and school functioning, significantly improved from pre- to post-ACT. Higher autistic traits were associated with greater pre- to post-ACT improvements in emotional functioning and sleep disturbance and non-significant improvements in pain interference. ADHD symptomatology was not associated with treatment outcome. The current results showed that neuropsychiatric symptoms in pediatric chronic pain patients are associated with lower functioning, particularly pain interfering with daily life and lower socioemotional functioning. The results suggest that not only pediatric chronic pain patients low in neuropsychiatric symptoms may benefit from ACT, but also those high in autism traits and ADHD symptoms. With the present results in mind, pediatric chronic pain patients higher in autistic traits may actually derive extra benefit from ACT. Future research could assess whether increased psychological flexibility, the core focus of ACT, enabled those higher in autism traits to cope relatively better with pain-related distress and thus to gain more from the treatment, as compared to those lower in autism traits. Moreover, to address specific effects of ACT, inclusion of an appropriate control group is key. AN - WOS:000642300500001 AU - Balter, L. J. T. AU - Lipsker, C. W. AU - Wicksell, R. K. AU - Lekander, M. C7 - 576943 DA - Apr DO - 10.3389/fpsyg.2021.576943 N1 - Balter, Leonie J. T. Wiwe Lipsker, Camilla Wicksell, Rikard K. Lekander, Mats PY - 2021 SN - 1664-1078 ST - Neuropsychiatric Symptoms in Pediatric Chronic Pain and Outcome of Acceptance and Commitment Therapy T2 - Frontiers in Psychology TI - Neuropsychiatric Symptoms in Pediatric Chronic Pain and Outcome of Acceptance and Commitment Therapy UR - ://WOS:000642300500001 VL - 12 ID - 1740 ER - TY - JOUR AB - PURPOSE: The purpose of this research was to describe 24-42 month outcomes of a combined inpatient/day hospital interdisciplinary pain rehabilitation program for children and adolescents with chronic pain and functional disability. METHODS: One-hundred-seventy-three children and adolescents (mean age=15.1 years, SD=2.5) were treated in the three-week program. Mixed effects regression models (MERM) examined changes over time in pain ratings (0-10), school days missed by children and work days missed by parents in the preceding week, and the number of days hospitalized in the preceding month. RESULTS: Participants reported a significant decline in pain from admission to 24-42 month follow-up. The largest declines in pain occurred from discharge to 1-month follow-up (6.20 vs. 4.81 on a 0-10 numerical rating scale) and from 12 months to 24-42 month follow-up (4.90 vs. 3.56). Two distinct trajectories of treatment response were identified using growth mixture modeling: children with initially high pain ratings exhibited large reductions in pain ratings, while those with lower pain ratings at admission showed minimal reductions. Treatment resulted in significant reductions in school and work days missed and the number of days hospitalized (all p's < 0.001), with reductions evident at 1-month follow-up and maintained through 24-42 month follow-up. CONCLUSIONS: These results suggest that interdisciplinary pain rehabilitation is a promising approach to chronic pain and associated disability in children, with enduring improvements found 24-42 months following program completion. Distinct trajectories of treatment response were identified. AD - Pediatric Pain Rehabilitation Program, Cleveland Clinic, Cleveland, OH, USA Center for Pediatric Behavioral Health, Cleveland Clinic, Cleveland, OH, USA Department of Developmental and Rehabilitation Pediatrics, Cleveland Clinic, Cleveland, OH, USA. Pediatric Pain Rehabilitation Program, Cleveland Clinic, Cleveland, OH, USA. Pediatric Pain Rehabilitation Program, Cleveland Clinic, Cleveland, OH, USA Department of Developmental and Rehabilitation Pediatrics, Cleveland Clinic, Cleveland, OH, USA. Pediatric Pain Rehabilitation Program, Cleveland Clinic, Cleveland, OH, USA Center for Pediatric Behavioral Health, Cleveland Clinic, Cleveland, OH, USA. AN - 25260503 AU - Banez, G. A. AU - Frazier, T. W. AU - Wojtowicz, A. A. AU - Buchannan, K. AU - Henry, D. E. AU - Benore, E. DO - 10.3233/prm-140289 DP - NLM ET - 2014/09/28 IS - 3 KW - Adolescent Child Chronic Pain/*rehabilitation Cohort Studies Disabled Children/*rehabilitation Female Humans Inpatients Longitudinal Studies Male Patient Care Team/*organization & administration Reaction Time Regression Analysis Treatment Outcome Adolescents interdisciplinary health team outcomes assessment pain rehabilitation LA - eng N1 - 1875-8894 Banez, Gerard A Frazier, Thomas W Wojtowicz, Andrea A Buchannan, Kristen Henry, Douglas E Benore, Ethan Journal Article Research Support, Non-U.S. Gov't Netherlands J Pediatr Rehabil Med. 2014;7(3):197-206. doi: 10.3233/PRM-140289. PY - 2014 SN - 1874-5393 SP - 197-206 ST - Chronic pain in children and adolescents: 24-42 month outcomes of an inpatient/day hospital interdisciplinary pain rehabilitation program T2 - J Pediatr Rehabil Med TI - Chronic pain in children and adolescents: 24-42 month outcomes of an inpatient/day hospital interdisciplinary pain rehabilitation program VL - 7 ID - 3211 ER - TY - JOUR AB - BACKGROUND CONTEXT: Back problems are reported with increasing frequency in adults and adolescents. Most information is from self-reported questionnaires or studies with small sample sizes. Reports were usually focused on specific diseases and biased toward overdiagnosis. PURPOSE: To assess the prevalence of common back disorders among a large cohort of 17-year-old males and females recruited by the Israel Defense Forces (IDF). STUDY DESIGN: A retrospective cross-sectional prevalence study. PATIENT SAMPLE: Seventeen-year-old Israeli male and female military recruits reporting as directed by the IDF for preinduction medical examination between January 01, 1998 and December 31, 2006. OUTCOME MEASURES: Military functional limitation Grades 1 to 7 per diagnosis category. METHODS: Military recruits were examined and classified based on medical and orthopedic diagnoses. They were referred for orthopedic consultation as necessary. Four orthopedic classifications were used: spinal deformity (including kyphosis and scoliosis), back pain (including neck and radicular syndromes), spondylolysis/olisthesis, and limitations resulting from trauma or spinal surgery. Data were coded into a central database, and descriptive statistics are presented. RESULTS: The overall prevalence of back disorders among 828,171 17-year-old military recruits (61.5% male) was 16.8%. Back disorders resulting in significant functional limitation were diagnosed in 0.8% of recruits. The most prevalent diagnoses were spinal deformities (kyphosis and scoliosis, females 11.9%, males 11.5%) and back pain (females 3.0%, males 5.6%). Most of these diagnoses were rated as mild. CONCLUSIONS: When using objective criteria, overall back disorders in a large population of 17-year-old recruits were 17%, considerably lower than most reports. Back morbidity severe enough to prevent combat duty occurred at a rate of less than 1%, suggesting that serious back morbidity is not a frequent finding in this age group. LEVEL OF EVIDENCE: Symptom prevalence study, Level III. (C) 2012 Elsevier Inc. All rights reserved. AN - WOS:000309527900005 AU - Bar-Dayan, Y. AU - Morad, Y. AU - Elishkevitz, K. P. AU - Bar-Dayan, Y. AU - Finestone, A. S. DA - Sep DO - 10.1016/j.spinee.2010.04.009 IS - 9 N1 - Bar-Dayan, Yosefa Morad, Yair Elishkevitz, Keren Politi Bar-Dayan, Yaron Finestone, Aharon S. Finestone, Aharon S/R-9001-2019 Finestone, Aharon S/0000-0003-1956-5557 1878-1632 Si PY - 2012 SN - 1529-9430 SP - 749-755 ST - Back disorders among Israeli youth: a prevalence study in young military recruits T2 - Spine Journal TI - Back disorders among Israeli youth: a prevalence study in young military recruits UR - ://WOS:000309527900005 VL - 12 ID - 2417 ER - TY - JOUR AB - We report the outcome of 19 children aged 5.2 to 13.2 years with 20 fractures of the femoral shaft requiring surgery, who were randomly assigned to have external fixation (EF) or flexible intramedullary nailing (FIN) (10 fractures each). The duration of the operation averaged 56 minutes for the EF group with 1.4 minutes of fluoroscopy, compared with 74 minutes and 2.6 minutes, respectively, for the FIN group. The early postoperative course was similar, but the FIN [corrected] group showed much more callus formation. The time to full weight-bearing, full range of movement and return to school were all shorter in the FIN group. The FIN complications included one transitory foot drop and two cases of bursitis at an insertion site. In the EF group there was one refracture, one rotatory malunion requiring remanipulation and two pin-track infections. At an average follow-up of 14 months two patients in the EF group had mild pain, four had quadriceps wasting, one had leg-length discrepancy of over 1 cm, four had malalignment of over 5 degrees, and one had limited hip rotation. In the FIN group, one patient had mild pain and one had quadriceps wasting; there were no length discrepancies, malalignment or limitation of movement. Parents of the FIN group were more satisfied. We recommend the use of flexible intramedullary nailing for fractures of the femoral shaft which require surgery, and reserve external fixation for open or severely comminuted fractures. AD - Hadassah Medical Centre, Jerusalem, Israel. AN - 9393916 AU - Bar-On, E. AU - Sagiv, S. AU - Porat, S. DA - Nov DO - 10.1302/0301-620x.79b6.7740 DP - NLM ET - 1997/12/11 IS - 6 KW - Absenteeism Adolescent Bone Malalignment/etiology Bone Nails/adverse effects Bony Callus/physiopathology Bursitis/etiology Child Child, Preschool Equipment Design *External Fixators/adverse effects Femoral Fractures/*surgery Fluoroscopy Follow-Up Studies Foot Diseases/etiology Fracture Fixation/adverse effects/*instrumentation *Fracture Fixation, Intramedullary/adverse effects/instrumentation Fracture Healing Humans Leg Length Inequality/etiology Movement Muscular Atrophy/etiology Pain, Postoperative/etiology Patient Satisfaction Prospective Studies Radiography, Interventional Recurrence Surgical Wound Infection/etiology Time Factors Weight-Bearing LA - eng N1 - Bar-On, E Sagiv, S Porat, S Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England J Bone Joint Surg Br. 1997 Nov;79(6):975-8. doi: 10.1302/0301-620x.79b6.7740. PY - 1997 SN - 0301-620X (Print) 0301-620x SP - 975-8 ST - External fixation or flexible intramedullary nailing for femoral shaft fractures in children. A prospective, randomised study T2 - J Bone Joint Surg Br TI - External fixation or flexible intramedullary nailing for femoral shaft fractures in children. A prospective, randomised study VL - 79 ID - 3504 ER - TY - JOUR AB - Children with sickle cell disease (SCD) are at risk for poor health-related quality of life (HRQOL). The current analysis sought to explore parent problem-solving abilities/skills as a moderator between SCD complications and HRQOL to evaluate applicability to pediatric SCD. At baseline, 83 children ages 6-12 years and their primary caregiver completed measures of child HRQOL. Primary caregivers also completed a measure of social problem-solving. A SCD complications score was computed from medical record review. Parent problem-solving abilities significantly moderated the association of SCD complications with child self-report psychosocial HRQOL (p = .006). SCD complications had a direct effect on parent proxy physical and psychosocial child HRQOL. Enhancing parent problem-solving abilities may be one approach to improve HRQOL for children with high SCD complications; however, modification of parent perceptions of HRQOL may require direct intervention to improve knowledge and skills involved in disease management. AN - WOS:000331958200006 AU - Barakat, L. P. AU - Daniel, L. C. AU - Smith, K. AU - Robinson, M. R. AU - Patterson, C. A. DA - Mar DO - 10.1007/s10880-013-9379-7 IS - 1 N1 - Barakat, Lamia P. Daniel, Lauren C. Smith, Kelsey Robinson, M. Renee Patterson, Chavis A. Daniel, Lauren/AAA-3700-2021 Daniel, Lauren/0000-0002-8637-2424 1573-3572 PY - 2014 SN - 1068-9583 SP - 56-65 ST - Parental Problem-Solving Abilities and the Association of Sickle Cell Disease Complications with Health-Related Quality of Life for School-Age Children T2 - Journal of Clinical Psychology in Medical Settings TI - Parental Problem-Solving Abilities and the Association of Sickle Cell Disease Complications with Health-Related Quality of Life for School-Age Children UR - ://WOS:000331958200006 VL - 21 ID - 2317 ER - TY - JOUR AB - The importance of the use of analgesic medication for the symptomatic relief of pain has been underestimated in medical practice. The objective of this study was to determine the prevalence of tension-type and migraine-type headaches and the associated analgesic consumption for its treatment within elementary school students from Porto Alegre (Brazil). A systematic random sample of 538 students from 5th to 8th grades was produced to complete the cross-sectional delineation. Subjects were individually submitted to a structured interview on headache and to general physical and neurological examination. Lifetime prevalence for headaches was 93.3%, 82.9% of the students recalled having headaches during the last year and 31.4% reported headaches in the last week. The prevalence for headaches in the previous 24 h was 8.9%. There was a significant prevalence of headache in females. The prevalence of analgesic consumption was 84.1% throughout life, 85.7% in the last year, and 54% in the last 3 months. A significantly higher prevalence of headache medication consumption was also depicted for females. However, the small age differences within the sample did not appear to be an important factor in influencing analgesic use for headaches. Different agents composed the individual treatment of headaches, with predominant use of over-the-counter preparations. Acetylsalicylic acid, consumed by 58.3% of the children, was the drug most frequently used for both tension-type and migraine-type headache treatments. In spite of the verification that headache was very frequently experienced by the children composing this sample accompanied by a consequent use of analgesics, no medication abuse was diagnosed. (C) 1997 John Wiley & Sons, Ltd. AN - WOS:A1997YF04200007 AU - Barea, L. M. AU - Rotta, N. T. AU - Stein, A. AU - Barros, H. M. T. AU - Tannhauser, M. DA - Sep-Oct IS - 5 N1 - Barea, LM Rotta, NT Stein, A Barros, HMT Tannhauser, M AT, Stein/AAD-8391-2020; Barros, Helena MT/I-4802-2014 AT, Stein/0000-0002-8756-8699; Barros, Helena MT/0000-0002-0779-7732 PY - 1997 SN - 1053-8569 SP - 359-366 ST - Analgesic use for headache treatment by schoolchildren of southern Brazil T2 - Pharmacoepidemiology and Drug Safety TI - Analgesic use for headache treatment by schoolchildren of southern Brazil UR - ://WOS:A1997YF04200007 VL - 6 ID - 2906 ER - TY - JOUR AB - Objective. To develop a valid and reliable measure of arthritis self-efficacy for use with school-age children with juvenile idiopathic arthritis (JIA). Methods. Construction of the 11-item Children's Arthritis Self-Efficacy Scale (CASE) was based on an existing body of knowledge and the results of focus groups with children, their parents, and health professionals. Data for validation of the CASE were collected by self-administered questionnaires completed by 89 children and 151 caregivers. Results. Analyses revealed a 3-factor structure relating to self-efficacy for managing symptoms, emotional consequences, and activities, explaining 76.5% of the total variance. The CASE demonstrated high internal consistency, concurrent validity, and construct validity. Conclusion. Preliminary findings suggest that the CASE is worthy of further psychometric testing and may have the potential to help delineate variations in adjustment among children with JIA. AN - WOS:000171872400009 AU - Barlow, J. H. AU - Shaw, K. L. AU - Wright, C. C. DA - Apr DO - 10.1002/1529-0131(200104)45:2<159::Aid-anr169>3.3.Co;2-u IS - 2 N1 - Barlow, JH Shaw, KL Wright, CC 1529-0131 PY - 2001 SN - 0004-3591 SP - 159-166 ST - Development and preliminary validation of a children's arthritis self-efficacy scale T2 - Arthritis & Rheumatism-Arthritis Care & Research TI - Development and preliminary validation of a children's arthritis self-efficacy scale UR - ://WOS:000171872400009 VL - 45 ID - 2850 ER - TY - JOUR AB - The purpose of this research was to analyze the oral health status of youth housed in socio-educational centers of the Juvenile Penal Area of the Province of Córdoba, Argentina of corrections by considering clinical evaluation and the main sociodemographic data. Socio-demographics, healthy and unhealthy habits of self-care, and dental clinical profile were assessed for this purpose. An exploratory cross-sectional study was carried out on 70 14- to 18-year-olds who had been institutionalized for at least six months. A clinical examination was conducted and the WHO Oral Health Survey was applied. Centralization and dispersion measurements, relative frequency, multiple correspondence analysis and generalized linear models were used to describe the data. The results showed: males 94%, mean age 16.91 ± 1.11, complete primary schooling 34%, from Córdoba City 69% and belonging to nuclear families 29%. Regarding healthy habits, 71% had frequent sugar intake, and 46% brushed teeth daily; while among unhealthy habits, 80% smoked tobacco, 63% drankalcohol and 73% used psychoactive substances. Sixty-three percent had visited a dentist once, and in 80% of the cases reason for the visit was pain. Clinical examination showed high prevalence of deterioration of the oral health component (DMFT = 8.94 ± 4.75, SiC = 14.26 ± 2.15, IPC3 = 56%, MO = 53%). Clinical profile showed marked prevalence of a very high level of caries severity, gingival disease and malocclusion, but not of initial stages of caries, alterations of enamel or temporomandibular dysfunction. The socio-demographic characteristics revealed conditions of social, educational and health vulnerability, a situation which interferes with the inclusion of these youths in the productive system and their access to better living conditions. AD - Universidad Nacional de Córdoba, Facultad de Odontología, Grupo de Investigación Interdisciplinario "Promoción Contextualizada", Argentina. marcebarnetche@gmail.com. Universidad Nacional de Córdoba, Facultad de Odontología, Grupo de Investigación Interdisciplinario "Promoción Contextualizada", Argentina. AN - 29750237 AU - Barnetche, M. M. AU - Cornejo, L. S. DA - Dec DP - NLM ET - 2018/05/12 IS - 3 KW - Adolescent Argentina Cross-Sectional Studies Female Humans Institutionalization Male *Oral Health Social Control, Formal Socioeconomic Factors Oral health Vulnerable populations LA - eng N1 - 1852-4834 Barnetche, María M Cornejo, Lila S Journal Article Argentina Acta Odontol Latinoam. 2017 Dec;30(3):129-140. OP - Salud bucal de jóvenes alojados en centros socioeducativos del Área Penal Juvenil de la Provincia de Córdoba, Argentina. PY - 2017 SN - 0326-4815 SP - 129-140 ST - Oral health of youth housed in socio-educational centers of the Juvenile Penal Area of the Province of Córdoba, Argentina T2 - Acta Odontol Latinoam TI - Oral health of youth housed in socio-educational centers of the Juvenile Penal Area of the Province of Córdoba, Argentina VL - 30 ID - 4033 ER - TY - JOUR AB - Sickle cell disease (SCD) occurs in 1 of every 400 to 500 African American births. Despite its prevalence, there has been a relative dearth of attention paid to SCD in the psychological literature. African American SCD adolescents and young adults, individuals at an already vulnerable developmental stage, are at increased risk for psychological distress and psychosocial impairments (e.g, depression and low self-esteem, poor social and academic/vocational functioning). Such difficulties often result in problematic adherence to medical regimens, and thus represent a potentially serious clinical and public health problem that merits the attention of psychologists working in medical settings. This article (I) reviews the psychosocial needs peculiar to SCD patients transitioning from adolescence to young adulthood; (2) applies a culturally informed stress-coping-adjustment framework to assess and address the psychological status, psychosocial functioning and disease outcomes of these individuals; and (3) describes a culturally and developmentally sensitive, psychoeducational group intervention. AN - WOS:000076301400007 AU - Baskin, M. L. AU - Collins, M. H. AU - Brown, F. AU - Griffith, J. R. AU - Samuels, D. AU - Moody, A. AU - Thompson, M. P. AU - Eckman, J. AU - Kaslow, N. J. DA - Sep DO - 10.1023/a:1026206204009 IS - 3 N1 - Baskin, ML Collins, MH Brown, F Griffith, JR Samuels, D Moody, A Thompson, MP Eckman, J Kaslow, NJ moody, alan/M-9258-2019 1573-3572 PY - 1998 SN - 1068-9583 SP - 315-341 ST - Psychosocial considerations in sickle cell disease (SCD): The transition from adolescence to young adulthood T2 - Journal of Clinical Psychology in Medical Settings TI - Psychosocial considerations in sickle cell disease (SCD): The transition from adolescence to young adulthood UR - ://WOS:000076301400007 VL - 5 ID - 2891 ER - TY - JOUR AB - P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis P002 - Lower serum immunoglobulin G2 level does not predispose to severe flu. J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego P003 - Brain protective effects of intravenous immunoglobulin through inhibition of complement activation and apoptosis in a rat model of sepsis F. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. Tuzun P004 - Adenosine a1 receptor dysfunction is associated with leukopenia: A possible mechanism for sepsis-induced leukopenia R. Riff, O. Naamani, A. Douvdevani P005 - Analysis of neutrophil by hyper spectral imaging - A preliminary report R. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. Shimazu P006 - Chemiluminescent intensity assessed by eaa predicts the incidence of postoperative infectious complications following gastrointestinal surgery S. Ono, T. Kubo, S. Suda, T. Ueno, T. Ikeda P007 - Serial change of c1 inhibitor in patients with sepsis – A prospective observational study T. Hirose, H. Ogura, H. Takahashi, M. Ojima, J. Kang, Y. Nakamura, T. Kojima, T. Shimazu P008 - Comparison of bacteremia and sepsis on sepsis related biomarkers T. Ikeda, S. Suda, Y. Izutani, T. Ueno, S. Ono P009 - The changes of procalcitonin levels in critical patients with abdominal septic shock during blood purification T. Taniguchi, M. O P010 - Validation of a new sensitive point of care device for rapid measurement of procalcitonin C. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. Lott P011 - Infection biomarkers in primary care patients with acute respiratory tract infections – Comparison of procalcitonin and C-reactive protein M. M. Meili, P. S. Schuetz P012 - Do we need a lower procalcitonin cut off? H. Hawa, M. Sharshir, M. Aburageila, N. Salahuddin P013 - The predictive role of C-reactive protein and procalcitonin biomarkers in central nervous system infections with extensively drug resistant bacteria V. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. Michaloudis P014 - Changes in endotoxin activity assay and procalcitonin levels after direct hemoperfusion with polymyxin-b immobilized fiber A. Kodaira, T. Ikeda, S. Ono, T. Ueno, S. Suda, Y. Izutani, H. Imaizumi P015 - Diagnostic usefullness of combination biomarkers on ICU admission M. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-Alcantara P016 - Platelet function analysis utilising the PFA-100 does not predict infection, bacteraemia, sepsis or outcome in critically ill patients N. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. Nee P017 - Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients G. Nicolaes, M. Wiewel, M. Schultz, K. Wildhagen, J. Horn, R. Schrijver, T. Van der Poll, C. 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Meissonnier P023 - Diagnosing sepsis in 5 minutes: Nanofluidic technology study with pancreatic-stone protein (PSP/ reg) L. Girard, F. Rebeaud P024 - How nanotechnology-based approaches could contribute to sepsis prevention, diagnosis and treatment I. Herrmann P025 - Il7r transcriptional expression analysis during septic shock B. Delwarde, E. Peronnet, E. Cerrato, F. Venet, A. Lepape, T. Rimmelé, G. Monneret, J. Textoris P026 - Disbalance of microbial metabolites of aromatic acids affects the severity in critically ill patients N. Beloborodova, V. Moroz, A. Osipov, A. Bedova, Y. Sarshor, A. Pautova, A. Sergeev, E. Chernevskaya P027 - Copeptin predicts 10-year all-cause mortality in community patients J. Odermatt, R. Bolliger, L. Hersberger, M. Ottiger, M. Christ-Crain, B. Mueller, P. Schuetz P028 - Identification of differential proteomic response in septic patients secondary to community and hospital acquired pneumonia N. K. Sharma, A. K. Tashima, M. K. Brunialti, F. R. Machado, M. Assuncao, O. Rigato, R. Salomao P029 - Monocyte HLA-DR expression in community-acquired bacteremic sepsis - dynamics associated to aetiology and prediction of secondary sepsis S. C. Cajander, G. Rasmussen, E. Tina, B. Söderquist, J. Källman, K. Strålin P030 - Soluble B- and T-lymphocyte attenuator: A possible prognostic marker in sepsis A. L. Lange, J. S. Sundén-Cullberg, A. M. Magnuson, O. H. Hultgren P031 - Fractal dimension: A new biomarker for quantifying clot microstructure in patients across the sepsis spectrum G. Davies, S. Pillai, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans P032 - Comparison between the new biomarker for coagulation, clot microstructure (Df) with rotational thromboelastometry (ROTEM) in patients across the sepsis spectrum S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans P033 - Changes in fibrinolysis across the sepsis spectrum: The use of rotational thromboelastometry (ROTEM) lysis index (LI60) and D-Dimer concentration S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans P034 - The intensive care infection score – a promising marker for the prediction of infection and its severity. P. Van der Geest, M. Mohseni, J. Linssen, R. De Jonge, S. Duran, J. Groeneveld P035 - Challenges in the clinical diagnosis of sepsis R. Miller III, B. K. Lopansri, L. C. McHugh, A. Seldon, J. P. Burke P036 - Does zero heat flux thermometry more accurately identify sepsis on intensive care? J. Johnston, R. Reece-Anthony, A. Bond, A. Molokhia P037 - Advancing quality (AQ) sepsis programme: Improving early identification & treatment of sepsis in North West England. C. Mcgrath, E. Nsutebu P038 - Prehospital transport of acute septic patients P. Bank Pedersen, D. Pilsgaard Henriksen, S. Mikkelsen, A. Touborg Lassen P039 - Vasodilatory plant extracts gel as an alternative treatment for fever in critically ill patients R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P040 - Host response and outcome of hypothermic sepsis M. A. Wiewel, M. B. Harmon, L. A. Van Vught, B. P. Scicluna, A. J. Hoogendijk, J. Horn, A. H. Zwinderman, O. L. Cremer, M. J. Bonten, M. J. Schultz, T. Van der Poll, N. P. Juffermans, W. J. Wiersinga P041 - Septic shock alert over SIRS criteria has an impact on outcome but needs to be revised G. Eren, Y Tekdos, M. Dogan, O. Acicbe, E. Kaya, O. Hergunsel P042 - Association between previous prescription of βblockers and mortality rate among septic patients: A retrospective observational study S. Alsolamy, G. Ghamdi, L. Alswaidan, S. Alharbi, F. Alenezi, Y. Arabi P043 - Recognition and treatment of sepsis on labour ward– teaching & information resources can improve knowledge J. Heaton, A. Boyce, L. Nolan, J. Johnston, A. Dukoff-Gordon, A. Dean, A. Molokhia P044 - Culture negative sepsis in the ICU – what is unique to this patient population? T. Mann Ben Yehudah P045 - Organ dysfunction in severe sepsis patients identified in administrative data in Germany, 2007-2013 C. Fleischmann, D. Thomas-Rueddel, C. Haas, U. Dennler, K. Reinhart P046 - A comparison of residents’ knowledge regarding; the Surviving Sepsis Campaign 2012 guideline O. Suntornlohanakul, B. Khwannimit P047 - Effectiveness of a septic shock bundle to improve outcomes in the ICU F. Breckenridge, A. Puxty P048 - Dose of norepinephrine in the first 24 hours as a parameter evaluating the effectiveness of treatment in patients with severe sepsis and septic shock P. Szturz, P. Folwarzcny, J. Svancara, R. Kula, P. Sevcik P049 - Norepinephrine or vasopressin + norepinephrine in septic shock. A retrospective series of 39 patients L. Caneva, A. Casazza, E. Bellazzi, S. Marra, L. Pagani, M. Vetere, R. Vanzino, D. Ciprandi, R. Preda, R. Boschi, L. Carnevale P050 - Methylene blue effectiveness as contributory treatment in patients with septic shock V. Lopez, M. Aguilar Arzapalo, L. Barradas, A. Escalante, J. Gongora, M. Cetina P051 - Coagulation disorders in patients with severe sepsis and DIC evaluated with thromboelastometry. B Adamik, D Jakubczyk, A Kübler P052 - Frequency and outcome of early sepsis-associated coagulopathy A. Radford, T. Lee, J. Singer, J. Boyd, D. Fineberg, M. Williams, J. Russell P053 - Assessment of coagulopathy in cancer patients with severe sepsis or septic shock. A case-control pilot study E. Scarlatescu, D. Tomescu, G. Droc, S. Arama P054 - Thromboelastometry in critically ill patients with disseminated intravascular coagulation M. Müller, M. Straat, S. S. Zeerleder, N. P. Juffermans P055 - Cessation of a preexisting chronic antiplatelet therapy is associated with increased mortality rates in severe sepsis and septic shock C. F. Fuchs, C. S. Scheer, S. W. Wauschkuhn, M. V. Vollmer, K. M. Meissner, S. K. Kuhn, K. H. Hahnenkamp, S. R. Rehberg, M. G. Gründling P056 - Neutrophil Extracellular Traps (NETs) production under hypoxic condition N. Yamamoto, M. Ojima, S. Hamaguchi, T. Hirose, Y. Akeda, R. Takegawa, O. Tasaki, T. Shimazu, K. Tomono P057 - Impact of ultraviolet air sterilizer in intensive care unit room, and clinical outcomes of patients E. Gómez-Sánchez, M. Heredia-Rodríguez, E. Álvarez-Fuente, M. Lorenzo-López, E. Gómez-Pesquera, M. Aragón-Camino, P. Liu-Zhu, A. Sánchez-López, A. Hernández-Lozano, M. T. Peláez-Jareño, E. Tamayo P058 - Focus of infection in severe sepsis - comparison of administrative data and prospective cohorts from Germany D. O. Thomas-Rüddel, C. Fleischmann, C. Haas, U. Dennler, K. Reinhart P059 - “Zero CLABSI” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU V. Adora, A. Kar, A. Chakraborty, S. Roy, A. Bandyopadhyay, M. Das P060 - Novel molecular techniques to identify central venous catheter (CVC) associated blood stream infections (BSIs) T. Mann Ben Yehudah, G. Ben Yehudah, M. Salim, N. Kumar, L. Arabi, T. Burger, P. Lephart, E. Toth-martin P061 - Zero clabsi” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU R. Rao, A. Kar, A. Chakraborty P062 - Prevention of central line-associated bloodstream infections in intensive care units: An international online survey C. Valencia, N. Hammami, S. Blot, J. L. Vincent, M. L. Lambert P063 - 30 days antimicrobial efficacy of non-leaching central venous catheters J. Brunke, T. Riemann, I. Roschke P064 - Efficacy of noble metal alloy-coated catheter in prevention of bacteriuria R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P065 - Predicting bacteremic urinary tract infection in community setting: A prospective observational study S. Nimitvilai, K. Jintanapramote, S. Jarupongprapa P066 - Eight-year analysis of acinetobacter spp. monobacteremia in surgical and medical intensive care units at university hospital in Lithuania D. Adukauskiene, D. Valanciene P067 - Group A and group B streptococcal infections in intensive care unit – our experience in a tertiary centre G. Bose, V. Lostarakos, B. Carr P068 - Improved detection of spontaneous bacterial peritonitis by uritop + tm strip test and inoculation of blood culture bottles with ascitic fluid S. Khedher, A. Maaoui, A. Ezzamouri, M. Salem P069 - Increased risk of cellulitis in patients with congestive heart failure: a population based cohort study J. Chen P070 - Outcomes of severe cellulitis and necrotizing fasciitis in the critically ill D. R. Cranendonk, L. A. Van Vught, M. A. Wiewel, O. L. Cremer, J. Horn, M. J. Bonten, M. J. Schultz, T. Van der Poll, W. J. Wiersinga P071 - Botulism outbreak associated with people who inject drugs (PWIDs) in Scotland. M. Day, G. Penrice, K. Roy, P. Robertson, G. Godbole, B. Jones, M. Booth, L. Donaldson P072 - Surveillance of ESBL-producing enterobacteriaceae fecal carriers in the ICU Y. Kawano, H. Ishikura P073 - Prevalence of ESBL and carbapenemase producing uropathogens in a newly opened hospital in south India S. Sreevidya, N. Brahmananda Reddy, P. Muraray Govind, R. Pratheema, J. Devachandran Apollo Speciality Hospital - OMR, Chennai, India P074 - Prevalence, risk factors and outcomes of methicillin-resistant staphylococcus aureus nasal colonization in critically ill patients H. Al-Dorzi, M. Almutairi, B. Alhamadi, A. Crizaldo Toledo, R. Khan, B. Al Raiy, Y. Arabi P075 - Multidrug-resistant Acinetobacter baumannii infection in intensive care unit patients in a hospital with building construction: Is there an association? H. Talaie P076 - Multidrug-resistant organisms in a Dutch ICU J. A. Van Oers, A. Harts, E. Nieuwkoop, P. Vos P077 - Epidemiology and risk factors of ICU acquired infections caused by multidrug-resistant gram negative bacilli Y. Boussarsar, F. Boutouta, S. Kamoun, I. Mezghani, S. Koubaji, A. Ben Souissi, A. Riahi, M. S. Mebazaa P078 - Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins E. Giamarellos-Bourboulis, N. Tziolos, C. Routsi, C. Katsenos, I. Tsangaris, I. Pneumatikos, G. Vlachogiannis, V. Theodorou, A. Prekates, E. Antypa, V. Koulouras, N. Kapravelos, C. Gogos, E. Antoniadou, K. Mandragos, A. Armaganidis P079 - Must change the medical practice in ICU? A. R. Robles Caballero, B. Civantos, J. C. Figueira, J. López P080 - Mediterranean spotted fever in an infectious diseases intensive care unit A. Silva-Pinto, F. Ceia, A. Sarmento, L. Santos P081 - Clinical features and outcomes of patients with Middle East respiratory syndrome requiring admission to a saudi intensive care unit: A retrospective analysis of 31 cases G. Almekhlafi, Y. Sakr P082 - The ICU response to a hospital outbreak of Middle East respiratory syndrome coronavirus infection H. Al-Dorzi, R. Khan, S. Baharoon, A. Aldawood, A. Matroud, J. Alchin, S. Al Johani, H. Balkhy, Y. Arabi P083 - Middle East respiratory syndrome: Surveillance data analysis S. Alsolamy, S. Y. Yousif, B. O. Alotabi, A. S. Alsaawi P085 - Use of Taqman array card molecular diagnostics in severe pneumonia: A case series J. Ang, MD Curran, D. Enoch, V. Navapurkar, A. Conway Morris P086 - ‘BUNS’: An investigation protocol improves the ICU management of pneumonia R. Sharvill, J. Astin P087 - Pneumonia in patients following secondary peritonitis: epidemiological features and impact on mortality M. Heredia-Rodríguez, E. Gómez-Sánchez, M. T. Peláez-Jareño, E. Gómez-Pesquera, M. Lorenzo-López, P. Liu-Zhu, M. Aragón-Camino, A. Hernández-Lozano, A. Sánchez-López, E. Álvarez-Fuente, E. Tamayo P088 - The use of the “CURB-65 score” by emergency room clinicians in a large teaching hospital J. Patel, C. Kruger P089 - Incidence of community acquired pneumonia with viral infection in mechanically ventilated patients in the medical intensive care unit J. O’Neal, H. Rhodes, J. Jancik P090 - The SAATELLITE Study: Prevention of S aureus Nosocomial Pneumonia (NP) with MEDI4893, a Human Monoclonal Antibody (mAb) Against S aureus B. François, P. F. Laterre, P. Eggimann, A. Torres, M. Sánchez, P. F. Dequin, G. L. Bassi, J. Chastre, H. S. Jafri P091 - Risk factors and microbiological profile for nosocomial infections in trauma patients M. Ben Romdhane, Z. Douira, S. Kamoun, M. Bousselmi, A. Ben Souissi, Y. Boussarsar, A. Riahi, M.S. Mebazaa P092 - Correlation between percentages of ventilated patients developed vap and use of antimicrobial agents in ICU patients. A. Vakalos, V. Avramidis P093 - A comparison of two ventilator associated pneumonia surveillance techniques T. H. Craven, G. Wojcik, K. Kefala, J. McCoubrey, J. Reilly, R. Paterson, D. Inverarity, I. Laurenson, T. S. Walsh P094 - Lung ultrasound before and after fiberbronchoscopy - modifications may improve ventilator-associated pneumonia diagnosis S. Mongodi, B. Bouhemad, A. Orlando, A. Stella, G. Via, G. Iotti, A. Braschi, F. Mojoli P095 - Comparing the accuracy of predictors of mortality in ventilator-associated pneumonia M. Haliloglu, B. Bilgili, U. Kasapoglu, I. Sayan, M. Süzer Aslan, A. Yalcın, I. Cinel P096 - Impact of pRBCs transfusion on percentage of ventilated patients developed VAP in ICU patients A. Vakalos, V. Avramidis P097 - The impact of a series of interventions on the rate of ventilator associated pneumonia in a large teaching hospital H. E. Ellis, K. Bauchmuller, D. Miller, A Temple P098 - The EVADE study: Prevention of Nosocomial Pneumonia (NP) caused by P aeruginosa with MEDI3902, a Novel Bispecific Monoclonal Antibody, against P aeruginosa virulence factors J. Chastre, B. 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Arabi P111 - Does empiric antifungal therapy improve survival in septic critically ill patients? (immunocompromised excluded) A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal P112 - Neurocysticercosis-Qatar experience F. Paramba, N. Purayil, V. Naushad, O. Mohammad, V. Negi, P. Chandra P113 - Early indicators in acute haemorrhagic shock A. Kleinsasser P114 - Filtering of red blood cells reduces the inflammatory response of pulmonary cells in an in vitro model of mechanical ventilation M. R. Witrz, J. F. Buchner-Doeven, A. M. Tuip-de Boer, J. C. Goslings, N. P. Juffermans P115 - Microparticles from red blood cell transfusion induce a pro-coagulant and pro-inflammatory endothelial cell response M. Van Hezel, M. Straat, A Boing, R Van Bruggen, N Juffermans P116 - The contribution of cytokines on thrombosis development during hospitalization in ICU D. Markopoulou, K. Venetsanou, V. Kaldis, D. Koutete, D. Chroni, I. Alamanos P117 - Prophylactic enoxaparin dosing and adjustment through anti-xa monitoring in an inpatient burn unit L. Koch, J. Jancik, H. Rhodes, E. Walter P118 - Determination of optimal cut-off values of haemoglobin, platelet count and fibrinogen at 24 hours after injury associated with mortality in trauma patients K. Maekawa, M. Hayakawa, S. Kushimoto, A. Shiraishi, H. Kato, J. Sasaki, H. Ogura, T. Matauoka, T. Uejima, N. Morimura, H. Ishikura, A. Hagiwara, M. Takeda P119 - Trauma-induced coagulopathy - prothrombin complex concentrate vs fresh frozen plasma O. Tarabrin, S. Shcherbakow, D. Gavrychenko, G. Mazurenko, V. Ivanova, O. Chystikov P120 - First study to prove the superiority of prothrombin complex concentrates on mortality rate over fresh frozen plasma in patients with acute bleeding C. Plourde, J. Lessard, J. Chauny, R. Daoust P121 - Prothrombin complex concentrate vs fresh frozen plasma in obstetric massive bleeding S. Shcherbakow, O. Tarabrin, D. Gavrychenko, G. Mazurenko, O. Chystikov P122 - Impact of FFP transfusion on VAP in ICU patients A. Vakalos, V. Avramidis P123 - Preoperative platelet function test and the thrombin generation assay are predictive for blood loss after cardiac surgery L. Kropman, L. In het Panhuis, J. Konings, D. Huskens, E. Schurgers, M. Roest, B. De Laat, M. Lance P124 - Rotational thromboelastometry versus standard coagulation tests before surgical interventions M. Durila, P. Lukas, M. Astraverkhava, J. Jonas P125 - Correction of impaired clot quality and stability by fibrinogen and activated prothrombin complex concentrate in a model of severe thrombocytopenia I. Budnik, B. Shenkman P126 - Assessment of point-of-care prothrombin time analyzer as a monitor after cardiopulmonary bypass H. Hayami, Y. Koide, T. Goto P127 - Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements? R. Iqbal, Y. Alhamdi, N. Venugopal, S. Abrams, C. Downey, C. H. Toh, I. D. 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Sdougka P133 - The implementation of a massive haemorrhage protocol (mhp) for the management of major trauma: a ten year, single-centre study R. Mothukuri, C. Battle, K. Guy, G. Mills, P. Evans P134 - An integrated major haemorrhage protocol for pre-hospital and retrieval medical teams J. Wijesuriya, S. Keogh P135 - The impact of transfusion thresholds on mortality and cardiovascular events in patients with cardiovascular disease (non-cardiac surgery): a systematic review and meta-analysis A. Docherty, R. O’Donnell, S. Brunskill, M. Trivella, C. Doree, L. Holst, M. Parker, M. Gregersen, J. Almeida, T. Walsh, S. Stanworth P136 - The relationship between poor pre-operative immune status and outcome from cardiac surgery is specific to the peri-operative antigenic threat S. Moravcova, J. Mansell, A. Rogers, R. A. Smith, C. Hamilton-Davies P137 - Impact of simple clinical practice guidelines for reducing post-operative atrial fibrillation after cardiac surgery. A. Omar, M. Allam, O. 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Al Khulaifi P142 - Complex evaluation of endothelial dysfunction markers for prognosis of outcomes in patients undergoing cardiac surgery I. Mandel, S. Mikheev, I. Suhodolo, V. Kiselev, Y. Svirko, Y. Podoksenov P143 - New-onset atrial fibrillation in intensive care: incidence, management and outcome S. A. Jenkins, R. Griffin P144 - One single spot measurement of the sublingual microcirculation during acute pulmonary hypertension in a pig model of shock M. S. Tovar Doncel, A. Lima, C. Aldecoa, C. Ince P145 - Assessment of levosimendan as a therapeutic option to recruit the microcirculation in cardiogenic shock – initial experience in cardiac ICU A. Taha, A. Shafie, M. Mostafa, N. Syed, H. Hon P146 - Terlipressin vs. norepinephrine in the Potential Multiorgan Donor(PMD) F. Righetti, E. Colombaroli, G. Castellano P147 - Echocardiography in the potential heart donor exposed to substitution hormonotherapy F. Righetti, E. Colombaroli P148 - Machine learning can reduce rate of monitor alarms M. Hravnak, L. C. Chen, A. D. Dubrawski, G. C. Clermont, M. R. Pinsky P149 - Peripherally inserted central catheters placed in the ICU S. Gonzalez, D. Macias, J. Acosta, P. Jimenez, A. Loza, A. Lesmes, F. Lucena, C. Leon P150 - Recordings of abnormal central venous pressure waveform morphology during an episode of pulmonary hypertension in a porcine shock model M. S. Tovar Doncel, C. Ince, C. Aldecoa, A. Lima P151 - Ultrasound guided central venous access technique among French intensivists M. Bastide, J. Richecoeur, E. Frenoy, C. Lemaire, B. Sauneuf, F. Tamion, S. Nseir, D. Du Cheyron, H. Dupont, J. Maizel P152 - Predictive ability of the Pv-aCO2 gap in patients with shock M. Shaban, R. Kolko, N. Salahuddin, M. Sharshir, M. AbuRageila, A. AlHussain P153 - Comparison of echocardiography and pulmonary artery catheter measurements of hemodynamic parameters in critical ill patients P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, M. Slama P154 - The volume clamp method for noninvasive cardiac output measurement in postoperative cardiothoracic surgery patients: a comparison with intermittent pulmonary artery thermodilution J. Wagner, A. Körner, M. Kubik, S. Kluge, D. Reuter, B. Saugel P155 - Hemodynamic monitoring in patients with septic shock (SS) – CPCCO (continuous pulse contour cardiac output) vs. TEE (transesophageal echocardiography) E. Colombaroli, F. Righetti, G. Castellano P156 - Cardiac output measurement with transthoracic echocardiography in critically ill patients: a pragmatic clinical study T. Tran, D. De Bels, A. Cudia, M. Strachinaru, P. Ghottignies, J. Devriendt, C. Pierrakos P157 - Left ventricular outflow tract velocity time integral correlates with stroke volume index in mechanically ventilated patients Ó. Martínez González, R. Blancas, J. Luján, D. Ballesteros, C. Martínez Díaz, A. Núñez, C. Martín Parra, B. López Matamala, M. Alonso Fernández, M. Chana P158 - Transpulmonary thermodilution (TPTD) derived from femoral vs. jugular central venous catheter: validation of a previously published correction formula and a proprietary correction formula for global end-diastolic volume index (GEDVI) W. Huber, M. Eckmann, F. Elkmann, A. Gruber, I. Klein, R. M. Schmid, T. Lahmer P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi P159 - Venous return driving pressure and resistance in acute blood volume changes P. W. Moller, S. Sondergaard, S. M. Jakob, J. Takala, D. Berger P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi P161 - Analysis of duration of post-operative goal-directed therapy protocol C. Ostrowska, H. Aya, A. Abbas, J. Mellinghoff, C. Ryan, D. Dawson, A. Rhodes, M. Cecconi P162 - Hemodynamic optimization – back to square one? M. Cronhjort, O. Wall, E. Nyberg, R. Zeng, C. Svensen, J. Mårtensson, E. Joelsson-Alm P163 - Effectiveness of fluid thoracic content measurement by bioimpedance guiding intravascular volume optimization in patients with septic shock M. Aguilar Arzapalo, L. Barradas, V. Lopez, M. Cetina P164 - A systematic review on the role of internal jugular vein ultrasound measurements in assessment of volume status in critical shock patients N. Parenti, C. Palazzi, L. A. Amidei, F. B. Borrelli, S. C. Campanale, F. T. Tagliazucchi, G. S. Sedoni, D. L. Lucchesi, E. C. Carella, A. L Luciani P165 - Importance of recognizing dehydration in medical Intensive Care Unit M. Mackovic, N. Maric, M. Bakula P166 - Effect of volume for a fluid challenge in septic patients H. Aya, A. Rhodes, R. M. Grounds, N. Fletcher, M. Cecconi P167 - Fluid bolus practices in a large Australian intensive care unit B. Avard, P. Zhang P168 - Liberal late fluid management is associated with longer ventilation duration and worst outcome in severe trauma patients: a retrospective cohort of 294 patients M. Mezidi, J. Charbit, M. Ould-Chikh, P. Deras, C. Maury, O. Martinez, X. Capdevila P169 - Association of fluids and outcomes in emergency department patients hospitalized with community-acquired pneumonia P. Hou, W. Z. Linde-Zwirble, I. D. Douglas, N. S. Shapiro P170 - Association of positive fluid balance with poor outcome in medicosurgical ICU patients A. Ben Souissi, I. Mezghani, Y. Ben Aicha, S. Kamoun, B. Laribi, B. Jeribi, A. Riahi, M. S. Mebazaa P171 - Impact of fluid balance to organ dysfunction in critically ill patients C. Pereira, R. Marinho, R. Antunes, A. Marinho P172 - Volume bolus in ICU patients: do we need to balance our crystalloids? M. Crivits, M. Raes, J. Decruyenaere, E. Hoste P173 - The use of 6 % HES solution do not reduce total fluid requirement in the therapy of patients with burn shock V. Bagin, V. Rudnov, A. Savitsky, M. Astafyeva, I. Korobko, V. Vein P174 - Electron microscopic assessment of acute kidney injury in septic sheep resuscitated with crystalloids or different colloids T. Kampmeier , P. Arnemann, M. Hessler, A. Wald, K. Bockbreder, A. Morelli, H. Van Aken, S. Rehberg, C. Ertmer P175 - Alterations of conjunctival microcirculation in a sheep model of haemorrhagic shock and resuscitation with 0.9 % saline or balanced tetrastarch P. Arnemann, M. Hessler, T. Kampmeier, S. Rehberg, H. Van Aken, C. Ince, C. Ertmer P176 - A single centre nested pilot study investigating the effect of using 0.9 % saline or Plasma-Lyte 148 ® as crystalloid fluid therapy on gastrointestinal feeding intolerance in mechanically ventilated patients receiving nasogastric enteral nutrition S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, A. Psirides, P. Young P177 - A single centre nested pilot study investigating the effect on post-operative bleeding of using 0.9 % saline or Plasma-Lyte® 148 as crystalloid fluid therapy in adults in ICU after heart surgery S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, P. Young P178 - Extreme hypernatremia and sepsis in a patient with Huntington’s dementia: a conundrum in fluid management H. Venkatesh, S. Ramachandran, A. Basu, H. Nair P179 - Diagnosis and management of severe hypernatraemia in the critical care setting S. Egan, J. Bates P180 - Correlation between arterial blood gas and electrolyte disturbances during hospitalization and outcome in critically ill patients S. Oliveira, N. R. Rangel Neto, F. Q. Reis P181 - Missing the “I” in MUDPILES – a rare cause of high anion gap metabolic acidosis (HAGMA) C. P. Lee, X. L. Lin, C. Choong , K. M. Eu, W. Y. Sim , K. S. Tee, J. Pau , J. Abisheganaden P182 - Plasma NGAL and urinary output: potential parameters for early initiation of renal replacement therapy K. Maas, H. De Geus P183 - Renal replacement therapy for critically ill patients: an intermittent continuity E. Lafuente, R. Marinho, J. Moura, R. Antunes, A. Marinho P184 - A survey of practices related to renal replacement therapy in critically ill patients in the north of England. T. E. Doris, D. Monkhouse, T. Shipley, S. Kardasz, I Gonzalez P185 - High initiation creatinine associated with lower 28-day mortality in critically ill patients necessitating continuous renal replacement therapy S. Stads, A. J. Groeneveld P186 - The impact of Karnofsky performance scale on outcomes in acute kidney injury patients receiving renal replacement therapy on the intensive care unit I. Elsayed, N. Ward, A. Tridente, A. Raithatha P187 - Severe hypophosphatemia during citrate-anticoagulated CRRT A. Steuber, C. Pelletier, S. Schroeder, E. Michael, T. Slowinski, D. Kindgen-Milles P188 - Citrate regional anticoagulation for post dilution continuous renal replacement therapy S. Ghabina P189 - Citrate 18 mmol/l improves anticoagulation during RRT with adsorbing filters F. Turani, A. Belli, S. Busatti, G. Barettin, F. Candidi, F. Gargano, R. Barchetta, M. Falco P190 - Calcium gluconate instead of calcium chloride in citrate-anticoagulated CVVHD O. Demirkiran, M. Kosuk, S. Bozbay P191 - Enhanced clearance of interleukin-6 with continuous veno-venous haemodialysis (CVVHD) using Ultraflux EMiC2 vs. Ultraflux AV1000S V. Weber, J. Hartmann, S. Harm, I. Linsberger, T. Eichhorn, G. Valicek, G. Miestinger, C. Hoermann P192 - Removal of bilirubin with a new adsorbent system: in vitro kinetics S. Faenza, D. Ricci, E. Mancini, C. Gemelli, A. Cuoghi, S. Magnani, M. Atti P193 - Case series of patients with severe sepsis and septic shock treated with a new extracorporeal sorbent T. Laddomada, A. Doronzio, B. Balicco P194 - In vitro adsorption of a broad spectrum of inflammatory mediators with CytoSorb® hemoadsorbent polymer beads M. C. Gruda, P. O’Sullivan, V. P. Dan, T. Guliashvili, A. Scheirer, T. D. Golobish, V. J. Capponi, P. P. Chan P195 - Observations in early vs. late use of cytosorb therapy in critically ill patients K. Kogelmann, M. Drüner, D. Jarczak P196 - Oxiris membrane decreases endotoxin during rrt in septic patients with basal EAA > 0,6 F. Turani, A. B. Belli, S. M. Martni, V. C. Cotticelli, F. Mounajergi, R. Barchetta P197 - An observational prospective study on the onset of augmented renal clearance: the first report S. Morimoto, H. Ishikura P198 - An ultrasound- guided algorithm for the management of oliguria in severe sepsis I. Hussain, N. Salahuddin, A. Nadeem, K. Ghorab, K. Maghrabi P199 - Ultrasound in acute kidney injury (aki). First findings of farius, an education-programme in structural ultrasonography S. K. Kloesel, C. Goldfuss, A. Stieglitz, A. S. Stieglitz, L. Krstevska, G. Albuszies P200 - Effectiveness of renal angina index score predicting acute kidney injury on critically ill patients M. Aguilar Arzapalo, L. Barradas, V. Lopez, A. Escalante, G. Jimmy, M. Cetina P201 - Time length below blood pressure thresholds and progression of acute kidney injury in critically ill patients with or without sepsis: a retrospective, exploratory cohort study J. Izawa, T. Iwami, S. Uchino, M. Takinami, T. Kitamura, T. Kawamura P202 - Anaemia does not affect renal recovery in acute kidney injury J. G. Powell-Tuck, S. Crichton, M. Raimundo, L. Camporota, D. Wyncoll, M. Ostermann P203 - Estimated glomerular filtration rate based on serum creatinine: actual practice in Dutch ICU’s A. Hana, H. R. De Geus P204 - Comparison of estimated glomerular filtration rate calculated by mdrd, ckd-epi-serum-creatinine and ckd-epi-cystatin-c in adult critically ill patients H. R. De Geus, A. Hana P205 - Early diagnosis of septic acute kidney injury in medical critical care patients with a urine cell cycle arrest marker: insulin like growth factor binding protein-7 (IGFBP-7) M. Aydogdu, N. Boyaci, S. Yuksel, G. Gursel, A. B. Cayci Sivri P206 - Urinary neutrophil gelatinase-associated lipocalin as early biomarker of severe acute kidney injury in intensive care J. Meza-Márquez, J. Nava-López, R. Carrillo-Esper P207 - Shrunken pore syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting A. Dardashti, A. Grubb P208 - The biomarker nephrocheck™ can discriminate the septic shock patients with an akin 1 or 2 acute renal failure who will not progress toward the akin 3 level J. Maizel, M. Wetzstein, D. Titeca, L. Kontar, F. Brazier, B. De Cagny, A. Riviere, T. Soupison, M. Joris, M. Slama P209 - A worldwide multicentre evaluation of acute kidney injury in septic and non-septic critically ill patients: the intensive care over nations (icon) audit E. Peters, H. Njimi, P. Pickkers, J. L. Vincent P210 - Does enhanced recovery after surgery reduce the incidence of acute kidney injury in those undergoing major gynae-oncological surgery? M. Waraich , J. Doyle, T. Samuels, L. Forni P211 - Identification of risk factors for the development of acute kidney injury after lower limb arthroplasty N. Desai, R. Baumber, P. Gunning, A. Sell P212 - Incidences and associations of acute kidney injury after major trauma S. Lin, H. Torrence, M. O’Dwyer, C. Kirwan, J. Prowle P213 - Acute kidney injury of major trauma patients T Kim P214 - Trajectory of serum creatinine after major surgery and the diagnosis of acute kidney injury M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle P215 - Epidemiology of acute kidney injury after cardiac surgery. A single center retrospective study S. Hanoura , A. Omar, H. Othamn, S. Sudarsanan , M. Allam, M. Maksoud, R. Singh, A. Al Khulaifi P216 - Post-operative acute kidney injury after major non-cardiac surgery and its association with death in the following year M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle P217 - Factors affecting acute renal failure in intensive care unit and effect of these factors on mortality O. Uzundere, D. Memis , M. Ýnal, A. , N. Turan P218 - Results of the live kidney transplantations according to national data of turkish organ and tissue information system M. A. Aydin, H. Basar, I. Sencan, A. Kapuagasi, M. Ozturk, Z. Uzundurukan, D. Gokmen, A. Ozcan, C. Kaymak P219 - Anaesthesia procedure and intensive therapy in patients with neck phlegmon V. A. Artemenko, A. Budnyuk P220 - Nasal high flow oygen for acute respiratory failure: a systematic review R. Pugh , S. Bhandari P221 - Setting optimal flow rate during high flow nasal cannula support: preliminary results T. Mauri, C. Turrini, T. Langer, P. Taccone, C. A. Volta, C. Marenghi, L. Gattinoni, A. Pesenti P222 - Dose to dose consistency across two different gas flow rates using cystic fibrosis and normal adult breathing profiles during nasal high flow oxygen therapy L. Sweeney, A . O’ Sullivan, P. Kelly, E. Mukeria, R. MacLoughlin P223 - Final results of an evaluation of airway medix closed suction system compared to a standard closed suction system M. Pfeffer, J. T. Thomas, G. B. Bregman, G. K. Karp, E. K. Kishinevsky, D. S. Stavi, N. A. Adi P224 - Different cuff materials and different leak tests - one size does not fit all T. Poropat, R. Knafelj P225 - Observational study on the value of the cuff-leak test and the onset of upper airway obstruction after extubation E. Llopart, M. Batlle, C. De Haro, J. Mesquida, A. Artigas P226 - A device for emergency transtracheal lung ventilation D. Pavlovic, L. Lewerentz, A. Spassov, R. Schneider P227 - Long-term outcome and health-related quality of life in patients discharged from the intensive care unit with a tracheostomy and with or without prolonged mechanical ventilation S. De Smet, S. De Raedt, E. Derom, P Depuydt, S. Oeyen, D. Benoit, J. Decruyenaere P228 - Ultrasound-guided percutaneous dilational tracheostomy versus bronchoscopy-guided percutaneous dilational tracheostomy in critically ill patients (trachus): a randomized clinical trial A. Gobatto, B. Bese, P. Tierno, L. Melro, P. Mendes, F. Cadamuro, M. Park, L. M. Malbouisson P229 - Is it safe to discharge patients with tracheostomy from the ICU to the ward? B. C. Civanto, J. L. Lopez, A. Robles, J. Figueira, S. Yus, A. Garcia P230 - The application of tracheostomy in children in ICU A. Oglinda, G. Ciobanu, C. Oglinda, L. Schirca, T. Sertinean, V. Lupu P231 - The impact of passive humidifiers on aerosol drug delivery during mechanical ventilation P. Kelly, A. O’Sullivan, L. Sweeney, R. MacLoughlin P232 - Evaluation of vibrating mesh and jet nebuliser performance at two different attachment setups in line with a humidifier nebuliser system A. O’Sullivan, P. Kelly, L. Sweeney, E. Mukeria, M. Wolny , R. MacLoughlin P233 - Psv-niv versus cpap in the treatment of acute cardiogenic pulmonary edema A. Pagano, F. Numis, G. Vison, L. Saldamarco, T. Russo, G. Porta, F. Paladino P234 - Noninvasive ventilation in patients with haematologic malignancy: a retrospective review C. Bell, J. Liu, J. Debacker, C. Lee, E. Tamberg, V. Campbell, S. Mehta P235 - Use of non-invasive ventilation in infectious diseases besides classical indications A. Silva-Pinto, A. Sarmento, L. Santos P236 - The impact of fragility on noninvasive mechanical ventilation application and results in the ICU Ý. Kara, F. Yýldýrým, A. Zerman, Z. Güllü, N. Boyacý, B. Basarýk Aydogan, Ü. Gaygýsýz, K. Gönderen, G. Arýk, M. Turkoglu, M. Aydogdu, G. Aygencel, Z. Ülger, G. Gursel P237 - Effects of metabolic alkalosis on noninvasive ventilation success and ICU outcome in patients with hypercapnic respiratory failure N. Boyacý, Z. Isýkdogan, Ö. Özdedeoglu, Z. Güllü, M. Badoglu, U. Gaygýsýz, M. Aydogdu, G. Gursel P238 - Asynchrony index and breathing patterns of acute exacerbation copd patients assisted with noninvasive pressure support ventilation and neurally adjusted ventilatory assist N. Kongpolprom, C. Sittipunt P239 - High frequency jet ventilation for severe acute hypoxemia A. Eden, Y. Kokhanovsky, S. Bursztein – De Myttenaere, R. Pizov P240 - HFOV revisited: a 7 year retrospective analysis of patients receiving HFOV who met oscillate trial entry criteria L. Neilans, N. MacIntyre P241 - Implementation of a goal-directed mechanical ventilation order set driven by respiratory therapists can improve compliance with best practices for mechanical ventilation M. Radosevich, B. Wanta, V. Weber, T. Meyer, N. Smischney, D. Brown, D. Diedrich P242 - A reduction in tidal volumes for ventilated patients on ICU calculated from IBW. can it minimise mortality in comparison to traditional strategies? A . Fuller, P. McLindon, K. Sim P243 - Predictive value of lung aeration scoring using lung ultrasound in weaning failure M. Shoaeir, K. Noeam, A. Mahrous, R. Matsa, A. Ali P244 - Conventional versus automated weaning from mechanical ventilation using SmartCare™ C. Dridi, S. Koubaji, S. Kamoun, F. Haddad, A. Ben Souissi, B. Laribi, A. Riahi, M. S. Mebazaa P245 - Ultrasonographic evaluation protocol for weaning from mechanichal ventilation A. Pérez-Calatayud, R. Carrillo-Esper, A. Zepeda-Mendoza, M. Diaz-Carrillo, E. Arch-Tirado P246 - Diaphragm ultrasonography: a method for weaning patients from mechanical ventilation S. Carbognin, L. Pelacani, F. Zannoni, A. Agnoli, G. Gagliardi P247 - Dorsal diaphragmatic excursion tracks transpulmonary pressure in ventilated ARDS patients: a potential non-invasive indicator of lung recruitment? R. Cho, A. Adams , S. Lunos, S. Ambur, R. Shapiro, M. Prekker P248 - Pulse oximetry in the icu patient: is the perfusion index of any value? M. Thijssen, L. Janssen, N. Foudraine P249 - Ventilation is a better assessment of respiratory status than EtCO2 C. J. Voscopoulos, J. Freeman P250 - Evaluation of the relationship between non-invasive minute ventilation and end-tidal CO2 in patients undergoing general vs spinal anesthesia C. J. Voscopoulos, J. Freeman, E. George P251 - Respiratory volume monitoring provides early warning of respiratory depression and can be used to reduce false alarms in non-intubated patients C. J. Voscopoulos, D. Eversole, J. Freeman, E. George P252 - P/i index: a predictive edi-derived weaning index during nava S. Muttini, R. Bigi, G. Villani, N. Patroniti P253 - Adequacy of ventilation in patients receiving opioids in the post anesthesia care unit: minute ventilation versus respiratory rate G. Williams, C. J. Voscopoulos, J. Freeman, E. George P254 - Comparison of regional and global expiratory time constants measured by electrical impedance tomography (EIT) A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis P255 - Electrical impedance tomography: robustness of a new pixel wise regional expiratory time constant calculation A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis P256 - Validation of regional and global expiratory time constant measurement by electrical impedance tomography in ards and obstructive pulmonary diseases C. K. Karagiannidis, A. W. Waldmann, S. B. Böhm, S. Strassmann, W. W. Windisch P257 - Transpulmonary pressure in a model with elastic recoiling lung and expanding chest wall P. Persson, S. Lundin, O. Stenqvist P258 - Lactate in pleural and abdominal effusion G. Porta, F. Numis, C. S. Serra, A. P. Pagano, M. M. Masarone, L. R. Rinaldi, A. A. Amelia, M. F. Fascione, L. A. Adinolfi, E. R. Ruggiero P259 - Outcome of patients admitted to the intensive care with pulmonary fibrosis F. Asota, K. O’Rourke, S. Ranjan, P. Morgan P260 - Sedation and analgesia practice in extra-corporeal membrane oxygenation (ECMO)-treated patients with acute respiratory distress syndrome (ARDS): a retrospective study J. W. DeBacker, E. Tamberg, L. O’Neill, L. Munshi, L. Burry, E. Fan, S. Mehta P261 - Characteristics and outcomes of patients deemed not eligible when referred for veno-venous extracorporeal membrane oxygenation (vv-ECMO) S. Poo, K. Mahendran, J. Fowles, C. Gerrard, A. Vuylsteke P262 - The SAVE SMR for veno-arterial ECMO R. Loveridge, C. Chaddock, S. Patel, V. Kakar, C. Willars, T. Hurst, C. Park, T. Best, A. Vercueil, G. Auzinger P263 - A simplified score to predict early (48 h) mortality in patients being considered for VA-ECMO A. Borgman, A. G. Proudfoot, E. Grins, K. E. Emiley, J. Schuitema, S. J. Fitch, G. Marco, J. Sturgill, M. G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge P264 - Lung function six months post extra corporeal membrane oxygenation (ECMO) for severe acute respiratory failure in adult survivors C. Sampson, S. Harris-Fox P265 - Bicarbonate dialysis removes carbon dioxide in hypoventilated rodents. M. E. Cove, L. H. Vu, A. Sen, W. J. Federspiel, J. A. Kellum P266 - Procalcitonin as predictor of primary graft dysfunction and mortality in post-lung transplantation C. Mazo Torre, J. Riera, S. Ramirez, B. Borgatta, L. Lagunes, J. Rello P267 - New molecular biomarkers of acute respiratory distress syndrome in abdominal sepsis A. K. Kuzovlev, V. Moroz, A. Goloubev, S. Polovnikov, S. Nenchuk P268 - Tight junction’s proteins claudin -5 and regulation by tnf in experimental murine lung injury model of ali/ards V. Karavana, C. Glynos, A. Asimakos, K. Pappas, C. Vrettou, M. Magkou, E. Ischaki, G. Stathopoulos, S. Zakynthinos P269 - Cell counts in endobronchial aspirate to assess airway inflammation in ARDS patients: a pilot study S. Spadaro, I. Kozhevnikova, F. Dalla Corte, S. Grasso, P. Casolari, G. Caramori, C. Volta P270 - Epidemiological and clinical profile of patients with acute respiratory distress syndrome in the surgical intensive care unit surgical, hospital JRA, Antananarivo T. Andrianjafiarinoa, T. Randriamandrato, T. Rajaonera P271 - Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS. Is it good for the lung and for the heart? S. El-Dash, ELV Costa, MR Tucci, F Leleu, L Kontar, B. De Cagny, F. Brazier, D. Titeca, G. Bacari-Risal, J. Maizel, M. Amato, M. Slama P272 - Effect of recruitment maneuver on left ventricular systolic strain P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, S. El Dash, M. Slama P273 - Inhaled nitric oxide – is switching supplier cost effective? Remmington, A. Fischer, S. Squire, M. Boichat P274 - Epidemiological study of severe acute pancreatitis in Japan, comparison of the etiology and the patient outcomes on 1159 patients. H. Honzawa, H. Yasuda, T. Adati, S. Suzaki, M. Horibe, M. Sasaki, M. Sanui P275 - Extracorporeal liver support therapy. Experience in an intensive care unit R. Marinho, J. Daniel, H. Miranda, A. Marinho P276 - Accuracy of mortality prediction models in acute versus acute-on-chronic liver failure in the intensive care setting K. Milinis, M. Cooper, G. R. Williams, E. McCarron, S. Simants, I. Patanwala, I. Welters P277 - Risk of coronary artery disease in patients with chronic liver disease: a population based cohort study Y. Su P278 - 20 years of liver transplantation in Santiago de Compostela (Spain). Experience review J. Fernández Villanueva, R. Fernández Garda, A. López Lago, E. Rodríguez Ruíz, R. Hernández Vaquero, S. Tomé Martínez de Rituerto, E. Varo Pérez P279 - Diarrhea is a risk factor for liver injury and may lead to intestinal failure associated liver disease in critical illness N. Lefel, F. Schaap, D. Bergmans, S. Olde Damink, M. Van de Poll P280 - Bowel care on the intensive care unit: constipation guideline compliance and complications K. Tizard, C. Lister, L. Poole P281 - Malnutrition assessed by phase angle determines outcomes in low risk cardiac surgery patients D. Ringaitiene, D. Gineityte, V. Vicka, I. Norkiene, J. Sipylaite P282 - Preoperative fasting times in an irish hospital A. O’Loughlin, V. Maraj, J. Dowling P283 - Costs and final outcome of early x delayed feeding in a private Brazil ICU M. B. Velasco, D. M. Dalcomune, E. B. Dias, S. L. Fernandes P284 - Can ventilator derived energy expenditure measurements replace indirect calorimetry? T. Oshima, S. Graf, C. Heidegger, L. Genton, V. Karsegard, Y. Dupertuis, C. Pichard P285 - Revisiting the refeeding syndrome: results of a systematic review N. Friedli, Z. Stanga, B. Mueller, P. Schuetz P286 - Compliance with the new protocol for parenteral nutrition in our ICU L. Vandersteen, B. Stessel, S. Evers, A. Van Assche, L. Jamaer, J. Dubois P287 - Nutrition may be another treatment in the intensive care unit where less is more? R. Marinho, H. Castro, J. Moura, J. Valente, P. Martins, P. Casteloes, C. Magalhaes, S. Cabral, M. Santos, B. Oliveira, A. Salgueiro, A. Marinho P288 - Should we provide more protein to critically ill patients? R. Marinho, M. Santos, E. Lafuente, H. Castro, S. Cabral, J. Moura, P. Martins, B. Oliveira, A. Salgueiro, S. Duarte, S. Castro, M. Melo, P. Casteloes, A. Marinho P289 Protein provision in an adult intensive care unit S. Gray P290 - Prevalence and clinical outcomes of vitamin d deficiency in the medical critically ill patients in Songklanagarind hospital K. Maipang, R. Bhurayanontachai P291 - Vitamin d deficiency strongly predicts adverse medical outcome across different medical inpatient populations: results from a prospective study L. G. Grädel, P. Schütz P292 - Omega-3 fatty acids in patients undergoing cardiac surgery: a systematic review and meta-analysis P. Langlois, W. Manzanares P293 - Can 5-hydroxytriptophan prevent post-traumatic stress disorder in critically ill patients? R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P294 - Parenteral selenium in the critically ill: an updated systematic review and meta-analysis W. Manzanares, P. Langlois, M. Lemieux, G. Elke, F. Bloos, K. Reinhart, D. Heyland P295 - Probiotics in the critically ill: an updated systematic review and meta-analysis P. Langlois, M. Lemieux, I. Aramendi, D. Heyland, W. Manzanares P296 - Diabetes with hyperglycemic crisis episodes may be associated with higher risk of pancreatic cancer: a population-based cohort study Y. Su P297 - Incidence of hypoglycemia in an intensive care unit depending on insulin protocol R. Marinho, N. Babo, A. Marinho P298 - Severity of the diseases is two-dimensionally correlated to blood glucose, including blood glucose variability, especially in moderately to severely ill patients with glucose intolerance. M. Hoshino, Y. Haraguchi, S. Kajiwara, T. Mitsuhashi, T. Tsubata, M. Aida P299 - A study of glycemic control by subcutaneous glargine injection transition from continuous regular insulin infusion in critically ill patients T. Rattanapraphat, R. Bhurayanontachai, C. Kongkamol, B. Khwannimit P300 - Glycemic control in Portuguese intensive care unit R. Marinho, M. Santos, H. Castro, E. Lafuente, A. Salgueiro, S. Cabral, P. Martins, J. Moura, B. Oliveira, M. Melo, B. Xavier, J. Valente, C. Magalhaes, P. Casteloes, A. Marinho P301 - Impact of hyperglycemia duration on the day of operation on short-term outcome of cardiac surgery patients D. Moisidou, F. Ampatzidou, C. Koutsogiannidis, M. Moschopoulou, G. Drossos P302 - Lactate levels in diabetic ketoacidosis patients at ICU admissions G. Taskin, M. Çakir, AK Güler, A. Taskin, N. Öcal, S. Özer, L. Yamanel P303 - Intensive care implications of merging heart attack centre units in London J. M. Wong, C. Fitton, S. Anwar, S. Stacey P304 - Special characteristics of in-hospital cardiac arrests M. Aggou, B. Fyntanidou, S. Patsatzakis, E. Oloktsidou, K. Lolakos, E. Papapostolou, V. Grosomanidis P305 - Clinical evaluation of ICU-admitted patients who were resuscitated in the general medicine ward S. Suda , T. Ikeda, S. Ono, T. Ueno, Y. Izutani P306 - Serious game evaluation of a one-hour training basic life support session for secondary school students: new tools for future bystanders S. Gaudry, V. Desailly, P. Pasquier, PB Brun, AT Tesnieres, JD Ricard, D. Dreyfuss, A. Mignon P307 - Public and clinical staff perceptions and knowledge of CPR compared to local and national data J. C White, A. Molokhia, A. Dean, A. Stilwell, G. Friedlaender P308 Dispatcher-assisted telephone cardiopulmonary resuscitation using a French-language compression-ventilation pediatric protocol M. Peters, S. Stipulante, A. Delfosse, AF Donneau, A. Ghuysen P309 Dantrolene versus amiodarone for resuscitation – an experimental study C. Feldmann, D. Freitag, W. Dersch, M. Irqsusi, D. Eschbach, T. Steinfeldt, H. Wulf, T. Wiesmann P310 Long term survival and functional neurological outcome in comatose survivors undergoing therapeutic hypothermia N. Kongpolprom, J. Cholkraisuwat P311 Impact of kidney disease on mortality and neurological outcome in out-of-hospital cardiac arrest: a prospective observational study S. Beitland , E. Nakstad, H. Stær-Jensen , T. Drægni , G. Andersen , D. Jacobsen , C. Brunborg, B. Waldum-Grevbo , K. Sunde P312 ICU dependency of patients admitted after primary percutaneous coronary intervention (PPCI) following out of the hospital cardiac arrest K. Hoyland, D. Pandit P313 Prognostic indicators and outcome prediction model for patients with return of spontaneous circulation from cardiopulmonary arrest: comprehensive registry of in-hospital intensive care on OHCA survival (critical) study in Osaka, Japan K. Hayakawa P314 Cerebral oxygen saturation during resuscitation in a porcine model of cardiac arrest E. Oloktsidou, K. Kotzampassi, B. Fyntanidou, S. Patsatzakis, L. Loukipoudi, E. Doumaki, V. Grosomanidis P315 Presumption of cardiopulmonary resuscitation for sustaining cerebral oxidation using regional cerebral saturation of oxygen: observational cohort study (press study) H. Yasuda P316 EEG reactivity in patients after cardiac arrest: a close look at stimuli MM Admiraal, M. Van Assen, MJ Van Putten, M. Tjepkema-Cloostermans, AF Van Rootselaar, J. Horn P317 Prognostic value of neuron-specific enolase after cardiac arrest F. Ragusa, A. Marudi , S. Baroni, A. Gaspari, E. Bertellini P318 Correlation between electroencephalographic findings and serum neuron specific enolase with outcome of post cardiac arrest patients A. Taha, T. Abdullah, S. Abdel Monem P319 Introduction of a targeted temperature management strategy following cardiac arrest in a district general hospital intensive care unit. S. Alcorn, S. McNeill, S. Russell P320 The evolution of cerebral oxygen saturation in post-cardiac arrest patients treated with therapeutic hypothermia W. Eertmans, C. Genbrugge, I. Meex, J. Dens, F. Jans, C. De Deyne P321 Prognostic factors and neurological outcomes of therapeutic hypothermia in comatose survivors from cardiac arrest: 8-year single center experience J. Cholkraisuwat, N. Kongpolprom P322 Adherence to targeted temperature management after out of hospital cardiac arrest B. Avard, R. Burns P323 Implementation of a therapeutic hypothermia protocol for comatose survivors of out-of-hospital cardiac arrest. A. Patarchi, T. Spina P324 Factors associated with ventilator weaning after targeted temperature management for cardiac arrest patients in japan H. Tanaka, N. Otani, S. Ode, S. Ishimatsu P325 Differential activation of c-fos in paraventricular nuclei of the hypothalamus and thalamus of the rat following myocardial infarction J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin, M. H. Won P326 Monitoring of cTroponin I in patients with acute ischemic stroke - predictor of inhospital mortality S. Dakova, Z. Ramsheva, K. Ramshev P327 Hyperthermic preconditioning severely accelerates neuronal damage in the gerbil ischemic hippocampal dentate gyrus via decreasing sods expressions J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin P328 Failure in neuroprotection of remote limb ischemic post conditioning in the hippocampus of a gerbil model of transient cerebral ischemia J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin P329 Brain death and admission diagnosis in neurologic intensive care unit, a correlation? A Marudi, S Baroni, A Gaspari, E Bertellini P330 Brain magnetic resonance imaging findings in patients with septic shock G. Orhun, E. Senturk, P. E. Ozcan, S. Sencer, C. Ulusoy, E. Tuzun, F . Esen P331 Benefits of L-carnitine in valproic acid induced encephalopathy R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P332Automatic analysis of EEG reactivity in comatose patients M. Van Assen, M. M. Admiraal, M. J. Van Putten, M. Tjepkema-Cloostermans, A. F. Van Rootselaar, J. Horn P333 Usefulness of common ICU severity scoring systems in predicting outcome after spontaneous intracerebral hemorrhage M. Fallenius, M. B. Skrifvars, M. Reinikainen, S. Bendel, R. Raj P334 Evalution of patients with suspected subarachnoid haemorrhage and negative ct imaging M. Abu-Habsa, C. Hymers, A. Borowska, H. Sivadhas, S. Sahiba, S. Perkins P335 Timing of endovascular and surgical treatment for aneurysmal subarachnoid haemorrhage: early but not so fast. J. Rubio, J. A. Rubio, R. Sierra P336 Red blood cell transfusion in aneurysmal subarachnoid hemorrhage – the Sahara cohort study S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre P337 - Aneurysmal subarachnoid hemorrhage and anemia: a canadian multi-centre retrospective cohort study S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre P338 - Does the neutrophil-to-lymphocyte (NLR) ratio predict symptomatic vasospasm or delayed cerebral ischemia (DCI) after aneurysmal subarachnoid haemorrhage (SAH)? T. Groza, N. Moreau, D. Castanares-Zapatero, P. Hantson P339 - ICU-acquired infections in aneurysmal subarachnoid hemorrhage patients: impact on ICU and hospital length of stay M. Carbonara , F. Ortolano, T. Zoerle, S. Magnoni, S. Pifferi, V. Conte, N. Stocchetti P340 - Cerebral metabolic effects of normobaric hyperoxia during the acute phase of aneurysmal subarachnoid hemorrhage L. Carteron, T. Suys, C. Patet, H. Quintard, M. Oddo P341 - Postoperative care for elective craniotomy: where is best done? J. A. Rubio, J. Rubio, R. Sierra P342 - 5-year follow-up of patients after transplantation of organs from donors from neurocritical care V. Spatenkova, E. Pokorna, P. Suchomel P343 - Evaluation of levetiracetam pharmacokinetics after severe traumatic brain injury in neurocritical care patients at a level one trauma center N. Ebert, J. Jancik, H. Rhodes P344 - Model based time series cluster analysis to determine unique patient states in traumatic brain injury T. Bylinski, C. Hawthorne, M. Shaw, I. Piper, J. Kinsella P345 - Brain compartment monitoring capabilities from ICP to BI (bioimpedance) during HS (hypertonic saline) administration. State of art simulation outcome depending on brain swelling type A. K. Kink , I. R. Rätsep P346 - Transfusion of red blood cells in patients with traumatic brain injury admitted to Canadian trauma health centers: a multicenter cohort study A. Boutin, L. Moore, M. Chasse, R. Zarychanski, F. Lauzier, S. English, L. McIntyre, J. Lacroix, D. Griesdale, P. Lessard-Bonaventure, A. F. Turgeon P347 - Hemoglobin thresholds and red blood cell transfusions in adult patients with moderate or severe traumatic brain injury: a retrospective cohort study A. Boutin, L. Moore, R. Green, P. Lessard-Bonaventure, M. Erdogan, M. Butler, F. Lauzier, M. Chasse, S. English, L. McIntyre, R. Zarychanski, J. Lacroix, D. Griesdale, P. Desjardins, D. A. Fergusson, A. F. Turgeon P348 - Characteristics of patients with gunshot wounds to the head - an observational Brazilian study B. Goncalves, B. Vidal, C. Valdez, A. C. Rodrigues, L. Miguez, G. Moralez P349 - Base excess as predictor for ICU admission and the injury severity in blunt trauma patients T. Hong P350 - Enhancement of usual emergency department care with proadrenomedullin to improve outcome prediction - Results from the multi-national, prospective, observational TRIAGE study A. Kutz, P. Hausfater, D. Amin, T. Struja, S. Haubitz, A. Huber, B. Mueller, P. Schuetz P351 - Developing an innovative emergency medicine point-of-care simulation programme T. Brown, J. Collinson, C. Pritchett, T. Slade P352 - The InSim program: an in situ simulation program for junior trainees in intensive care M. Le Guen, S. Hellings, R. Ramsaran P353 - Impact of excessive and inappropriate troponin testing in the emergency setting how good are we A. Alsheikhly P354 - The development of time tracking monitor at emergency department T. Abe P355 - Role of focussed echocardiography in emergency assessment of syncope L. Kanapeckaite, M. Abu-Habsa, R. Bahl P356 - Insertion of an open-ended 14-gauge catheter through the chest wall causes a significant pneumothorax in a self-ventilating swine model M. Q Russell, K. J. Real, M. Abu-Habsa , R. M. Lyon, N. P. Oveland P357 - Ez-io® intraosseous access teaching in the workplace using a mobile ‘tea trolley’ training method J. Penketh, M. Mcdonald, F. Kelly P358 - Black widow envenomation in Saudi Arabia: a prospective observational case series M. Alfafi, S. Alsolamy, W. Almutairi, B. Alotaibi P359 - Mechanical ventilation in patients with overdose not yet intubated on icu admission A. E. Van den Berg, Y. Schriel, L. Dawson, I. A. Meynaar P360 - Central nervous system depressants poisoning and ventilator associated pneumonia: an underrated risk factor in toxicological intensive care unit H. Talaie P361 - Acute barium intoxication treated with hemodiafiltration D. Silva, S. Fernandes, J. Gouveia, J. Santos Silva P362 - Major trauma presenting to the emergency department. the spectrum of cycling injuries in Ireland J. Foley, A. Kaskovagheorgescu, D. Evoy, J. Cronin, J. Ryan P363 - Burns from French military operations: a 14-year retrospective observational analysis. M. Huck, C. Hoffmann, J. Renner, P. Laitselart, N. Donat, A. Cirodde, J. V. Schaal, Y. Masson, A. Nau, T. Leclerc P364 - A comparison of mortality scores in burns patients on the intensive care unit. O. Howarth, K. Davenport, P. AD - University of Western Ontario, London, Canada. ISNI: 0000 0004 1936 8884. GRID: grid.39381.30 Hospital Dr Negrín, Las Palmas de GC, Spain Hospital San Jorge, Huesca, Spain. ISNI: 0000 0004 1765 5935. GRID: grid.415076.1 Hospital Universitari del Mar, Barcelona, Spain. ISNI: 0000 0004 1767 8811. GRID: grid.411142.3 Hospital Universitario de la Princesa, Madrid, Spain. ISNI: 0000 0004 1767 647X. GRID: grid.411251.2 Hospital Clínico y Universitario de Valencia, Valencia, Spain. GRID: grid.411308.f Hospital Universitari Son Espases, Palma de Mallorca, Spain. ISNI: 0000 0004 1796 5984. GRID: grid.411164.7 Medical Faculty of Istanbul, Istanbul University, Anesthesiology and Intensive Care, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Medical Faculty of Istanbul, Physiology, Istanbul University, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Institute of Experimental Medicine, Istanbul University, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Medical Faculty of Istanbul, Forensic Medicine, Istanbul University, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Institute of Experimental Medicine, Immunology, Istanbul University, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Ben-Gurion University of the Negev, Beer-Sheva, Israel. ISNI: 0000 0004 1937 0511. GRID: grid.7489.2 Soroka Medical Center, Beer-Sheva, Israel. ISNI: 0000 0004 0470 8989. GRID: grid.412686.f Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. ISNI: 0000 0000 8902 2273. GRID: grid.174567.6 Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo Japan. GRID: grid.411909.4 National Defense Medical College, Tokorozawa, Saitama Japan. ISNI: 0000 0004 0374 0880. GRID: grid.416614.0 Hachiouji medical center, Tokyo medical university, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 Kanazawa University, Kanazawa, Japan. ISNI: 0000 0001 2308 3329. GRID: grid.9707.9 Kanazawa University Hospital, Kanazawa, Japan. ISNI: 0000 0004 0615 9100. GRID: grid.412002.5 ThermoFisher, Hennigsdorf, Germany Institut für Klinische Chemie und Laboratoriumsmedizin, Mainz, Germany MVZ Labor Limbach Gruppe, Berlin, Germany Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 Tokyo Medical University, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan. GRID: grid.411909.4 Hospital Virgen de la Victoria, Málaga, Spain. ISNI: 0000 0000 9788 2492. GRID: grid.411062.0 St Helens and Knowsley NHS Trust, Merseyside, UK Maastricht University, Maastricht, Netherlands. ISNI: 0000 0001 0481 6099. GRID: grid.5012.6 Center for Experimental and Molecular medicine, Amsterdam, Netherlands Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 NISCHR Haemostasis Biomarker Research Unit, Swansea, UK Hôpital Lariboisière, Paris, France. ISNI: 0000 0000 9725 279X. GRID: grid.411296.9 Sphingotec, Berlin, Germany Hôpital Cochin, Paris, France. ISNI: 0000 0001 0274 3893. GRID: grid.411784.f Hôpital Saint-Antoine, Paris, France. ISNI: 0000 0004 1937 1100. GRID: grid.412370.3 CHRU de Montpellier, Montpellier, France. ISNI: 0000 0000 9961 060X. GRID: grid.157868.5 Hôpital Saint-Louis, Paris, France. ISNI: 0000 0001 2300 6614. GRID: grid.413328.f AP-HM, Marseille, France. ISNI: 0000 0001 0407 1584. GRID: grid.414336.7 Hôpital Ambroise Paré, Paris, France. ISNI: 0000 0000 9982 5352. GRID: grid.413756.2 Christiana Care Health System, Newark, USA. ISNI: 0000 0004 0444 1241. GRID: grid.414316.5 Skane University Hospital, Lund University, Lund, Sweden. ISNI: 0000 0001 0930 2361. GRID: grid.4514.4 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. ISNI: 0000 0000 9828 7548. GRID: grid.8194.4 Hadassah-Hebrew University Medical Center, Jerusalem, Israel. ISNI: 0000 0001 2221 2926. GRID: grid.17788.31 LeukoDx, Jerusalem, Israel Abionic SA, Lausanne, Switzerland Swiss Federal Laboratories (Empa), St. Gallen, Switzerland Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia University Hospital Basel, Basel, Switzerland. GRID: grid.410567.1 UNIFESP, Sao Paulo, Brazil. ISNI: 0000 0001 0514 7202. GRID: grid.411249.b Albert Einstein Hospital, Sao Paulo, Brazil. ISNI: 0000 0001 0385 1941. GRID: grid.413562.7 Sírio Libanês Hospital, Sao Paulo, Brazil Faculty of Medicine and Health Örebro University, Örebro, Sweden. ISNI: 0000 0001 0738 8966. GRID: grid.15895.30 Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden. ISNI: 0000 0000 9241 5705. GRID: grid.24381.3c Faculty of Medicine and Health, Örebro, Sweden Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. ISNI: 0000 0000 9241 5705. GRID: grid.24381.3c Erasmus Medical Center, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 University Witten/Herdecke, Witten, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b Maasstad Ziekenhuis, Rotterdam, Netherlands. ISNI: 0000 0004 0460 0556. GRID: grid.416213.3 Intermountain Healthcare, Salt Lake City, USA. ISNI: 0000 0004 0460 774X. GRID: grid.420884.2 Immunexpress, Seattle, USA Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e Wirral trust, Merseyside, UK RLBUHT, Liverpool, UK Department of Emergency Medicine, Odense University Hospital, Odense C, Denmark. ISNI: 0000 0004 0512 5013. GRID: grid.7143.1 Department of Respiratory Medicine, Odense University Hospital, Odense C, Denmark. ISNI: 0000 0004 0512 5013. GRID: grid.7143.1 Department of Anaesthesiology and Intensive Care Medicine, Odense University Hospital, Odense C, Denmark. ISNI: 0000 0004 0512 5013. GRID: grid.7143.1 Bucharest Clinical Emergency Hospital, Bucharest, Romania Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 University Medical Center Utrecht, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. ISNI: 0000 0004 0419 1043. GRID: grid.414177.0 King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b Assaf Harofeh MC, Beer Yaakov, Israel Jena University Hopital, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d Prince of Songkla University, Hat Yai, Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 Division of Critical Care Medicine, Hat Yai, Thailand Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic. ISNI: 0000 0004 0609 0692. GRID: grid.412727.5 Institute of Biostatistics and analyses, Masaryk University, Brno, Czech Republic. ISNI: 0000 0001 2194 0956. GRID: grid.10267.32 Università degli studi di Pavia, scuola di specialità: Anestesia e Rianimazione, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy Università degli studi di Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b Hospital O’horan, Mérida, Mexico Department of Anaesthesiology and Intensive Therapy, Medical University, Wroclaw, Poland. ISNI: 0000 0001 1090 049X. GRID: grid.4495.c AKPA, Waltham, USA St. Paul’s Hospital, Vancouver, Canada. ISNI: 0000 0000 8589 2327. GRID: grid.416553.0 University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania. ISNI: 0000 0000 9828 7548. GRID: grid.8194.4 Acedemisch Medisch Centrum, Amsterdam, Netherlands University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c Division of Infection Control and Prevention, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b Department of Emergency Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. ISNI: 0000 0000 8902 2273. GRID: grid.174567.6 Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 Jena University Hospital, Jena, Germany. ISNI: 0000 0000 8517 6224. GRID: grid.275559.9 Medica Superspecialty Hospital, Kolkata, West Bengal India DMC, Detroit, USA. ISNI: 0000 0001 0088 6903. GRID: grid.413184.b Wayne State University, Detroit, USA. ISNI: 0000 0001 1456 7807. GRID: grid.254444.7 Scientific Institute of Public Health (WIV-ISP), Brussels, Belgium. ISNI: 0000 0004 0635 3376. GRID: grid.418170.b Ghent University, Ghent, Belgium. ISNI: 0000 0001 2069 7798. GRID: grid.5342.0 Erasme University, Brussels, Belgium QualityLabs Bt GmbH, Nuremberg, Germany B.Braun Melsungen AG, Melsungen, Germany. ISNI: 0000 0001 0699 8877. GRID: grid.462046.2 Dr. Roschke medical marketing GmbH, Cologne, Germany Nakhonpathom hospital, Nakhonpathom, Thailand Lithuanian University of Health Sciences, Kaunas,, Lithuania. ISNI: 0000 0004 0432 6841. GRID: grid.45083.3a University Hospital North Midlands, Stoke-on-Trent, UK EPS Charles-Nicolle, Bab Saadoun, Tunisia Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. ISNI: 0000000084992262. GRID: grid.7177.6 Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam, Netherlands Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a NHS Greater Glasgow and Clyde, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 Health Protection Scotland, Glasgow, UK. ISNI: 0000 0001 2232 4338. GRID: grid.413893.4 Public Health England, London, UK. ISNI: 0000 0001 2196 8713. GRID: grid.9004.d Fukuoka University Hospital, Fukuoka, Japan. ISNI: 0000 0004 0594 9821. GRID: grid.411556.2 King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. GRID: grid.411600.2 St. Elisabeth Hospital, Tilburg, Netherlands. GRID: grid.416373.4 Mongi Slim University Hospital, La Marsa, Tunisia University of Athens, Medical School, Athens, Greece. ISNI: 0000 0001 2155 0800. GRID: grid.5216.0 Korgialeneion Benakeion Hospital, Athens, Greece University of Thrace, Alexandroupolis, Greece. ISNI: 0000 0001 2170 8022. GRID: grid.12284.3d Aghios Dimitrios Hospital, Thessaloniki, Greece Tzaneion Hospital, Piraeus, Greece G.Gennimatas General Hospital, Thessaloniki, Greece. GRID: grid.414012.2 University of Ioannina, Ioannina, Greece. ISNI: 0000 0001 2108 7481. GRID: grid.9594.1 G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e University of Patras, Patras, Greece. ISNI: 0000 0004 0576 5395. GRID: grid.11047.33 Hospital Universitario La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 PSMMC, Riyadh, Saudi Arabia UNIKLINIKUM JENA, JENA, Germany King Fahad Medical City, Riyadh, Saudi Arabia. ISNI: 0000 0004 0593 1832. GRID: grid.415277.2 Addenbrooke’s Hospital, Cambridge, UK. ISNI: 0000 0004 0622 5016. GRID: grid.120073.7 University of Cambridge, Cambridge, UK. ISNI: 0000000121885934. GRID: grid.5335.0 Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b Salford Royal Hospital, London, UK. ISNI: 0000 0000 8535 2371. GRID: grid.415721.4 Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 CHU Dupuytren, Limoges, France. ISNI: 0000 0001 1481 5225. GRID: grid.412212.6 St Luc University Hospital, Brussels, Belgium. ISNI: 0000 0004 0461 6320. GRID: grid.48769.34 CHUV, Lausanne, Switzerland. ISNI: 0000 0001 0423 4662. GRID: grid.8515.9 Hospital Clinic of Barcelona, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c Hospital Clínico San Carlos, Madrid, Spain. ISNI: 0000 0001 0671 5785. GRID: grid.411068.a Université François Rabelais and CHU Bretonneau, Tours, France. ISNI: 0000 0001 2182 6141. GRID: grid.12366.30 Groupe Hospitalier Pitié-Salpêtrière, Paris, France. ISNI: 0000 0001 2150 9058. GRID: grid.411439.a MedImmune, Gaithersburg, USA. GRID: grid.418152.b Xanthi General Hospital, Xanthi, Greece Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d Western General Hospital, Edinburgh, UK. ISNI: 0000 0004 0624 9907. GRID: grid.417068.c Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b Centre Hospitalier Universitaire Dijon, Dijon, France. GRID: grid.31151.37 Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK. GRID: grid.419135.b University College, London, UK Cairo University, Giza, Egypt. ISNI: 0000 0004 0639 9286. GRID: grid.7776.1 University hospital Center of La Rabta, Tunis, Tunisia V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia N.V. Sklifosofsky Institute of Emergency Medicine, Moscow, Russia NN Burdenko Main Military Hospital, Moscow, Russia Novartis Pharmaceuticals, San Carlos, USA. ISNI: 0000 0004 0439 2056. GRID: grid.418424.f Nektar Therapeutics, San Francisco, CA USA. ISNI: 0000 0004 0410 3955. GRID: grid.476522.0 Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c Maine Medical Center, Portland, USA. GRID: grid.240160.1 Medical University of Vienna, Vienna, Austria. ISNI: 0000 0000 9259 8492. GRID: grid.22937.3d HIA Percy, Clamart, France. ISNI: 0000 0004 1795 3756. GRID: grid.414028.b Pherecydes Pharma, Romainville, France Hôpital Reine Astrid, Brussels, Belgium CHU Liege, Liege, Belgium. ISNI: 0000 0000 8607 6858. GRID: grid.411374.4 CH Saint Jospeh Saint Luc, Lyon, France Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f MUI, Innsbruck, Austria. ISNI: 0000 0000 8853 2677. GRID: grid.5361.1 Academic Medical Centre, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 Academic Medical Center Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 Sanquin, Amsterdam, Netherlands. ISNI: 0000 0001 2234 6887. GRID: grid.417732.4 KAT Hospital Athens, Kifisia, Greece. ISNI: 0000 0004 0622 8129. GRID: grid.415070.7 ICU-B, KAT Hospital Kifisia, Athens, Greece Hokkaido University Hospital, Sapporo, Japan. ISNI: 0000 0004 0378 6088. GRID: grid.412167.7 Tohoku University Graduate School of Medicine, Sendai, Japan. ISNI: 0000 0001 2248 6943. GRID: grid.69566.3a Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan. GRID: grid.474906.8 National Hospital Organization Disaster Medical Center, Tokyo, Japan. ISNI: 0000 0004 0569 9594. GRID: grid.416797.a Keio University School of Medicine, Tokyo, Japan. ISNI: 0000 0004 1936 9959. GRID: grid.26091.3c Osaka University Graduate School of Medicine, Osaka, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b Rinku General Medical Center, Osaka, Japan Kinki University Faculty of Medicine, Osaka, Japan. ISNI: 0000 0004 1936 9967. GRID: grid.258622.9 Yokohama City University Graduate School of Medicine, Yokohama, Japan. ISNI: 0000 0001 1033 6139. GRID: grid.268441.d Faculty of Medicine, Fukuoka University, Fukuoka, Japan. ISNI: 0000 0001 0672 2176. GRID: grid.411497.e National Center For Global Health and Medicine, Tokyo, Japan. ISNI: 0000 0004 0489 0290. GRID: grid.45203.30 Tokyo Women’s Medical University, Tokyo, Japan. ISNI: 0000 0001 0720 6587. GRID: grid.410818.4 Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b Hopital Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 Xanthi General Hospital, Xanth, Greece. GRID: grid.414012.2 Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. ISNI: 0000 0004 0611 0905. GRID: grid.412826.b Sechenov First Moscow Stat Medical University, Moscow, Russia Sheba Medical Center, Tel-Hashomer, Israel. ISNI: 0000 0001 2107 2845. GRID: grid.413795.d Yokohama Municipal Citizen’s Hospital, Yokohama, Japan. ISNI: 0000 0004 0377 5418. GRID: grid.417366.1 Hayama Heart Center, Hayama, Japan Yokohama City University Hospital, Yokohama, Japan. ISNI: 0000 0004 1767 0473. GRID: grid.470126.6 Institute of Ageing and Chronic Disease, Liverpool, UK Institute of Infection and Global Health, Liverpool, UK Department of Haematology, Royal Liverpool University Hospital (RLUH), Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e Hôpital du Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 Evelina London Children’s Hospital, London, UK St Thomas Hospital, London, UK. GRID: grid.425213.3 Intensive Care Unit, University of Ferrara, Italy, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Bruxelles, Belgium Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 Central London School of Anaesthesia and Intensive Care Medicine, London, UK University of the Sunshine Coast, Maroochydore, Australia. ISNI: 0000 0001 1555 3415. GRID: grid.1034.6 University of Edinburgh, Edinburgh, UK. ISNI: 0000 0004 1936 7988. GRID: grid.4305.2 John Radcliffe Hospital, Oxford, UK. ISNI: 0000 0001 2306 7492. GRID: grid.8348.7 Copenhagen University Hospital, Copenhagen, Denmark. ISNI: 0000 0004 0646 7373. GRID: grid.4973.9 Peterborough NHS Trust, Peterborough, UK Aarhus University, Aarhus, Denmark. ISNI: 0000 0001 1956 2722. GRID: grid.7048.b Hospital de Sao Paulo, Sao Paulo, Brazil. GRID: grid.413463.7 Royal Brompton & Harefield NHS Trust, London, UK. ISNI: 0000 0004 0581 2008. GRID: grid.451052.7 Barts Heart Centre, London, UK University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 Juntendo University Hospital, Tokyo, Japan. GRID: grid.411966.d Saitama Medical Center, Jichi Medical University, Saitama, Japan. ISNI: 0000000123090000. GRID: grid.410804.9 Gunma University Hospital, Maebashi, Japan. ISNI: 0000 0004 0595 7039. GRID: grid.411887.3 Yokohama City Minato Red Cross Hospital, Yokohama, Japan Research Institution for Cardiology, Tomsk, Russia Siberian State Medical University, Tomsk, Russia. ISNI: 0000 0001 0027 1685. GRID: grid.412593.8 The Hillingdon Hospitals NHS Foundation Trust, Middlesex, UK. ISNI: 0000 0004 0476 7073. GRID: grid.440199.1 University Hospital Rio Hortega, Valladolid, Spain. ISNI: 0000 0001 1842 3755. GRID: grid.411280.e Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. ISNI: 0000 0004 1773 3278. GRID: grid.415670.1 Intensive Care Unit, St. Boniface Hospital, Verona, Italy University of Pittsburgh, Pittsburgh, USA. ISNI: 0000 0004 1936 9000. GRID: grid.21925.3d Carnegie Mellon University, Pittsburgh, USA. ISNI: 0000 0001 2097 0344. GRID: grid.147455.6 Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 CH Beauvais, Beauvais, France Réanimation polyvalente, Le Havre, France CH Roubaix, Roubaix, France. ISNI: 0000 0004 0608 7784. GRID: grid.477297.8 CH Cotentin, Cherbourg, France CHU Rouen, Rouen, France. GRID: grid.41724.34 CHU Lille, Lille, France. ISNI: 0000 0004 0471 8845. GRID: grid.410463.4 CHU Caen, Caen, France. ISNI: 0000 0004 0472 0160. GRID: grid.411149.8 University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 Hospital Universitario del Tajo, Aranjuez, Spain Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain. ISNI: 0000 0004 1765 5855. GRID: grid.411338.c Hospital Universitario de San Carlos, Madrid, Spain. ISNI: 0000 0001 0671 5785. GRID: grid.411068.a Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland. ISNI: 0000 0004 0479 0855. GRID: grid.411656.1 Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e Karolinska Institutet, Stockholm, Sweden. ISNI: 0000 0004 1937 0626. GRID: grid.4714.6 Wenzhou Medical University, Wenzhou, Zheijang China. ISNI: 0000 0001 0348 3990. GRID: grid.268099.c Department of Intensive Care, Austin Hospital, Melbourne, VIC Australia. ISNI: 0000 0001 0162 7225. GRID: grid.414094.c Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 Clinical Hospital Sveti Duh, Zagreb, Croatia The Canberra Hospital, Hughes, ACT Australia. ISNI: 0000 0000 9984 5644. GRID: grid.413314.0 Australian National University Medical School, Canberra, Australia. ISNI: 0000 0001 2180 7477. GRID: grid.1001.0 Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 Brigham and Women’s Hospital, Boston, USA. ISNI: 0000 0004 0378 8294. GRID: grid.62560.37 Trexin Medical, Chicago, USA University of Colorado and Denver Health, Denver, USA. ISNI: 0000000107903411. GRID: grid.241116.1 Beth Isreal Deaconess, Boston, USA Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a University Hospital, Ghent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 City Clinical Hospital 40, Yekaterinburg, Russia University Hospital Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b Marienhospital Osnabrück, Osnabrück, Germany Charité, University of Berlin, Berlin, Germany Sapienza University of Rome, Rome, Italy. GRID: grid.7841.a University Hospital of Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b Erasmus MC University Hospital Rotterdam, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 Monash University, Melbourne, Australia. ISNI: 0000 0004 1936 7857. GRID: grid.1002.3 Austin Hospital, Melbourne, Australia. ISNI: 0000 0001 0162 7225. GRID: grid.414094.c Wellington Regional Hospital, Wellington, New Zealand. ISNI: 0000 0000 8862 6892. GRID: grid.416979.4 Australian and New Zealand Intensive Care Research Centre, Melbourne, Australia Princess of Wales Hospital, Bridgend, UK. ISNI: 0000 0004 0648 9337. GRID: grid.415249.f Imperial College London, London, UK. ISNI: 0000 0001 2113 8111. GRID: grid.7445.2 Glan Clwyd Hospital, Bodelwyddan, UK. ISNI: 0000 0000 9831 5916. GRID: grid.415564.7 University Hospital Galway, Galway, Ireland. ISNI: 0000 0004 0617 9371. GRID: grid.412440.7 Albert Schweitzer State Hospital, Rio de Janeiro, Brazil Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f National Neuroscience Institute, Singapore, Singapore. ISNI: 0000 0004 0636 696X. GRID: grid.276809.2 Erasmus Medical Centre, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 Centro Hospitalar Tamega e Sousa, Penafiel, Portugal. GRID: grid.466592.a Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal South Tees NHS Trust, Middlesbrough, UK Ikazia Hospital, Rotterdam, Netherlands. ISNI: 0000 0004 0568 7120. GRID: grid.414565.7 Sheffiled Teaching Hospitals, Sheffield, UK Whiston Hospital, St Helens & Knowsley, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 University Hospital Duesseldorf, Düsseldorf, Germany. ISNI: 0000 0000 8922 7789. GRID: grid.14778.3d Charite University Hospital, Berlin, Germany. ISNI: 0000 0001 2218 4662. GRID: grid.6363.0 Royal London Hospital, London, UK. ISNI: 0000 0001 0738 5466. GRID: grid.416041.6 Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 Istanbul University Cerrahpasa Medical School, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Danube University Krems, Krems, Austria. ISNI: 0000 0001 2108 5830. GRID: grid.15462.34 University Hospital St. Poelten, St. Poelten, Austria Teaching Hospital Policlinico S.Orsola-Malpighi, Bologna, Italy. GRID: grid.412311.4 Department of Nephrology, Dialysis, Hypertension, Bologna, Italy Science and Technology Park for Medicine, Mirandola, Italy Aferetica, Bologna, Italy San Marco Hospital, Zingonia, Italy CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 Klinikum Emden, Emden, Germany University Hospital Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 Aurelia Hospital /European Hospital, Rome, Italy. GRID: grid.414077.1 King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d Kyoto University, Kyoto, Japan. ISNI: 0000 0004 0372 2033. GRID: grid.258799.8 Osaka University, Osaka, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b Guy’s & St Thomas’ NHS Foundation Trust, London, UK. GRID: grid.420545.2 King’s College, London, UK. ISNI: 0000 0001 2322 6764. GRID: grid.13097.3c Hospital de Santa Maria, Lisbon, Portugal. ISNI: 0000 0001 2295 9747. GRID: grid.411265.5 ErasmusMC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 Gazi University Medical Faculty, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f Gazi University School of Medicine, Critical Care Fellowship Programme, Ankara, Turkey Gazi University School of Medicine Biochemistry Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f Fundación Clínica Medica Sur, Mexico City, Mexico Lund University and Skane University Hospital, Lund, Sweden. GRID: grid.411843.b Radboudumc, Nijmegen, Netherlands. ISNI: 0000 0004 0444 9382. GRID: grid.10417.33 Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. ISNI: 0000 0001 2348 0746. GRID: grid.4989.c The Royal Surrey County Hospital, Guildford, UK. ISNI: 0000 0004 0417 0648. GRID: grid.416224.7 Royal National Orthopaedic Hospital, Middlesex, UK. ISNI: 0000 0004 0417 7890. GRID: grid.416177.2 Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 Asan medical center, Seoul, South Korea. ISNI: 0000 0001 0842 2126. GRID: grid.413967.e Trakya Univ, Edirne, Turkey. ISNI: 0000 0001 2342 6459. GRID: grid.411693.8 General Directorate of Health Services, Ministry of Health, Ankara, Turkey. GRID: grid.415700.7 AnkaraNKARA Research and Training Hospital, Ankara, Turkey Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey. ISNI: 0000000109409118. GRID: grid.7256.6 Ankara Research and Training Hospital, Ankara, Turkey. ISNI: 0000 0004 0642 6432. GRID: grid.413783.a MC Into-Sana, Odessa, Ukraine Glan Clwyd Hospital, Rhyl, UK. ISNI: 0000 0000 9831 5916. GRID: grid.415564.7 Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy University of Ferrara, Sant’Anna Hospital, Ferrara, Italy Aerogen, Galway, Ireland Kaplan Medical Centre, Rehovot, Israel West Virginia University, Morgantown, West Virginia USA. ISNI: 0000 0001 2156 6140. GRID: grid.268154.c Rihard Knafelj, Ljubljana, Slovenia Corporació Sanitària i Universitària Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Sabadell, Barcelona, Spain. GRID: grid.7080.f Dalhousie University, Halifax, Canada. ISNI: 0000 0004 1936 8200. GRID: grid.55602.34 Ernst-Moritz-Arndt-Universität, Greifswald, Germany. GRID: grid.5603.0 Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 Hospital La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 Institute of Mother and Child, Chisinau mun., Moldova Institute of Emergency Medicine, Chisinau mun., Moldova State University of Medicine and Pharmacy, Chisinau mun., Moldova Cardarelli Hospital, Naples, Italy. GRID: grid.413172.2 San Paolo Hospital, Naples, Italy National University of Ireland, Galway, Galway City, Ireland. ISNI: 0000 0004 0488 0789. GRID: grid.6142.1 Mount Sinai Hospital, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f Gazi University School of Medicine, Internal Medicine Critical Care Department, Ankara, Turkey Gazi University School of Medicine, Geriatrics Department, Ankara, Turkey Chulalongkorn University, Bangkok, Thailand. ISNI: 0000 0001 0244 7875. GRID: grid.7922.e Carmel, Lady Davis Medical Center, Haifa, Israel. GRID: grid.471000.2 Duke University, Durham, USA. ISNI: 0000 0004 1936 7961. GRID: grid.26009.3d Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a St Helens and Knoowsley, Prescot, UK Royal Infirmary, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d Alexandria Universitry General Hospital, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 University Hospital North Middlands, Stoke On Trent, UK. ISNI: 0000 0004 0641 4263. GRID: grid.415598.4 Medica Sur, Mexico City, Mexico. GRID: grid.414741.3 Instituto Nacional de Rehabilitacion, Mexico City, Mexico. ISNI: 0000 0004 0633 2911. GRID: grid.419223.f University of Padua, Padua, Italy. ISNI: 0000 0004 1757 3470. GRID: grid.5608.b Sant Antony hospital, Padua, Italy HCMC, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 University of Minnesota, Minneapolis, USA. ISNI: 0000000419368657. GRID: grid.17635.36 Viecuri Medical Center, Venlo, Netherlands. ISNI: 0000 0004 0477 5022. GRID: grid.416856.8 University of Hawaii, John A. Burns School of Medicine, Honolulu, USA. ISNI: 0000 0001 2188 0957. GRID: grid.410445.0 Respiratory Motion Inc., Waltham, USA Massachusetts General Hospital, Boston, USA. ISNI: 0000 0004 0386 9924. GRID: grid.32224.35 AO Desio e Vimercate, Vimercate, Italy AO Crema, Crema, Italy University of Milan-Bicocca, Monza, Italy. ISNI: 0000 0001 2174 1754. GRID: grid.7563.7 UT Health Science Center at Houston, Houston, TX USA. ISNI: 0000 0000 9206 2401. GRID: grid.267308.8 University of Hawaii, John A. Burns School of Medicine, Honolulu, HI USA. ISNI: 0000 0001 2188 0957. GRID: grid.410445.0 Respiratory Motion Inc., Waltham, MA USA Massachusetts General Hospital, Boston, MA USA. ISNI: 0000 0004 0386 9924. GRID: grid.32224.35 Swisstom AG, Landquart, Switzerland Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten / Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten/ Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b ARDS and ECMO Center Köln-Merheim, Cologne, Germany Swisstom, Chur, Switzerland Sahlgrenska Univ Hospital, Göteborg, Sweden. ISNI: 000000009445082X. GRID: grid.1649.a Second University of Naples, Naples, Italy. ISNI: 0000 0001 2200 8888. GRID: grid.9841.4 University of Sassari, Sassari, Italy. ISNI: 0000 0001 2097 9138. GRID: grid.11450.31 University of Saerno, Salerno, Italy East Surrey Hospital, Surrey and Sussex NHS Trust, Surrey, UK Mount Sinai Hospital and University of Toronto, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 University Health Network-Toronto General Hospital and Univeristy of Toronto, Toronto, Canada. ISNI: 0000 0001 0661 1177. GRID: grid.417184.f Papworth Hospital, Cambridge, UK. ISNI: 0000 0004 0399 2308. GRID: grid.417155.3 King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d Meijer Heart & Vascular Institute, Grand Rapids, USA Glenfield Hospital, UHL, Leicester, UK. ISNI: 0000 0004 0648 9396. GRID: grid.416025.4 National University Hospital, Singapore, Singapore. ISNI: 0000 0004 0621 9599. GRID: grid.412106.0 National University Singapore, Singapore, Singapore. ISNI: 0000 0001 2180 6431. GRID: grid.4280.e Mayo Clinic, Phoenix, AZ USA. ISNI: 0000 0000 8875 6339. GRID: grid.417468.8 University of Pittsburgh, Pittsburgh, PA USA. ISNI: 0000 0004 1936 9000. GRID: grid.21925.3d Vall D’Hebron University Hospital, Barcelona, Spain. ISNI: 0000 0001 0675 8654. GRID: grid.411083.f Universitat Autonoma de Barcelona, Barcelona, Spain. GRID: grid.7080.f George P. Livanos and Marianthi Simou Laboratories, Athens, Greece University of Patras, Rio, Achaia Greece. ISNI: 0000 0004 0576 5395. GRID: grid.11047.33 University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 University of Bari, Bari, Italy. ISNI: 0000 0001 0120 3326. GRID: grid.7644.1 CHU HJRA, Antananarivo, Madagascar Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 Cardio-Pulmonary Department, Pulmonary Division, Heart Institute (Incor), University of São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 Royal Brompton Hospital, London, UK. GRID: grid.439338.6 Musashino Red Cross Hospital, Tokyo, Japan. ISNI: 0000 0000 9887 307X. GRID: grid.416332.1 JSEPTIC Clinical Trial Group, Tokyo, Japan University of Liverpool, Liverpool, UK. ISNI: 0000 0004 1936 8470. GRID: grid.10025.36 Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 MUMC, Maastricht, Netherlands. GRID: grid.412966.e Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. ISNI: 0000 0004 0567 3159. GRID: grid.426597.b Vilnius University, Faculty of Medicine, Vilnius, Lithuania Mercy University Hospital, Cork, Ireland. ISNI: 0000 0004 0575 9497. GRID: grid.411785.e Hospital Meridional S.A., Cariacica, Brazil Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c Medical University Department, Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 Department of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Bern, Bern, Switzerland. ISNI: 0000 0004 0479 0855. GRID: grid.411656.1 Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 Unidade de Saude Local de Castelo Branco, Castelo Branco, Portugal Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal. ISNI: 0000 0000 8902 4519. GRID: grid.418336.b Centro Hospitalar do Algarve, Faro, Portugal Instituto Portugues de Oncologia do Porto, Porto, Portugal. GRID: grid.435544.7 Faculdade de Ciencias da Nutricao e Alimentacao da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 Faculdade de Ciencias da Nutrição e Alimentação da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 Instituto Português de Oncologia do Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 Centro Hospitalar do Baixo Vouga, Aveiro, Portugal Nottingham University Hospital NHS Trust, Nottingham, UK. ISNI: 0000 0001 0440 1889. GRID: grid.240404.6 Prince of Songkla University, Songkla, Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 Université de Sherbrooke, Sherbrooke, Canada. ISNI: 0000 0000 9064 6198. GRID: grid.86715.3d University Hospital, Montevideo, Uruguay Queen’s University, Kingston, Canada. ISNI: 0000 0004 1936 8331. GRID: grid.410356.5 University Medical Center Schleswig-Holstein, Kiel, Germany. ISNI: 0000 0004 0646 2097. GRID: grid.412468.d University of Jena, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d Aida Hospital, Fukushima, Japan Keiyo Hospital, Tokyo, Japan Shisei Hospital, Saitama, Japan Prince of Songkla University, Hat Yai City, Songkhla Province Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 Centro Hospitalar Baixo Vouga, Aveiro, Portugal Department of Cardiothoracic Surgery, George Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e Gülhane Military Medical Academy, Ankara, Turkey. ISNI: 0000 0001 0720 6034. GRID: grid.413460.4 Ankara Mevki Military Hospital, Ankara, Turkey. GRID: grid.461837.f St Bartholomew’s Hospital, London, UK. ISNI: 0000 0000 9244 0345. GRID: grid.416353.6 Aristotle Medical School, Thessaloniki, Greece Tokyo Medical University Hachiosi Medical Center, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 Laboratoire ILUMENS, Paris, France Institut de Hauts de Seine, Nanterre, France University Hospital Lewisham, London, UK. GRID: grid.439787.6 Queen Elizabeth Hospital, London, UK. GRID: grid.439484.6 Minet Green Health Practice, London, UK Department of Public Health, University of Liège, Liège, Belgium. ISNI: 0000 0001 0805 7253. GRID: grid.4861.b Department of Emergency Medicine, University Hospital of Liège, Liège, Belgium. ISNI: 0000 0000 8607 6858. GRID: grid.411374.4 Department of Medical Biostatistics, University of Liège, Liège, Belgium. ISNI: 0000 0001 0805 7253. GRID: grid.4861.b University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 William Harvey Hospital, Ashford, UK. ISNI: 0000 0004 0398 7998. GRID: grid.417122.3 Kansai Medical University Takii Hospital, Moriguchi, Japan. GRID: grid.410783.9 Japanese Red Cross Musashino Hospital, Tokyo, Japan. ISNI: 0000 0004 1762 2623. GRID: grid.410775.0 Medisch Spectrum Twente, Enschede, Netherlands. ISNI: 0000 0004 0399 8347. GRID: grid.415214.7 University Modena, Modena, Italy. ISNI: 0000000121697570. GRID: grid.7548.e Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy Faculty of Medicine Alexandria University, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 Victoria Hospital, Kirkcaldy, UK. ISNI: 0000 0004 0624 9667. GRID: grid.416854.a Ziekenhuis Oost-Limburg, Genk, Belgium. ISNI: 0000 0004 0612 7379. GRID: grid.470040.7 ANU Medical School, Canberra, Australia. ISNI: 0000 0001 2180 7477. GRID: grid.1001.0 “Spirito Santo” Hospital, Pescara, Italy. GRID: grid.416240.5 St Lukes International Hospital, Akashi-Chou Chuo-Ku, Japan. GRID: grid.430395.8 Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 Military Medical Academy, Sofia, Bulgaria. ISNI: 0000 0004 0621 0228. GRID: grid.413126.3 Istanbul University, Medical Faculty of Istanbul, Anesthesiology and Intensive Care, Istanbul, Turkey Istanbul University, Medical Faculty of Istanbul, Department of Neuroradiology, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Istanbul University, Institute of Experimental Medicine, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e Helsinki University Hospital, Helsinki, Finland. ISNI: 0000 0000 9950 5666. GRID: grid.15485.3d North Karelia Central Hospital, Joensuu, Finland. ISNI: 0000 0004 0368 0478. GRID: grid.416446.5 Kuopio University Hospital, Kuopio, Finland. ISNI: 0000 0004 0628 207X. GRID: grid.410705.7 King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 Hospital Universitario Puerta del Mar, Cadiz, Spain. ISNI: 0000 0004 1771 1175. GRID: grid.411342.1 Hospital Infanta Cristina, Badajoz, Spain. ISNI: 0000 0004 1771 0842. GRID: grid.411319.f The Ottawa Hospital, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e Ulaval, Quebec City, Canada UBC, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e UManitoba, Winnipeg, Canada OHRI, Ottawa, Canada Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e Cliniques St Luc, Université catholique de Louvain, Brussels, Belgium. ISNI: 0000 0001 2294 713X. GRID: grid.7942.8 Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 Milan University, Milan, Italy. ISNI: 0000 0004 1757 2822. GRID: grid.4708.b CHU de Nice, Nice, France. ISNI: 0000 0001 2322 4179. GRID: grid.410528.a Regional Hospital, Liberec, Czech Republic. ISNI: 0000 0004 0609 0449. GRID: grid.447961.9 Institute of Experimental Medicine, Prague, Czech Republic. ISNI: 0000 0004 0404 6946. GRID: grid.424967.a University of Glasgow, Glasgow, UK. ISNI: 0000 0001 2193 314X. GRID: grid.8756.c Institute of Neurological Sciences, NHSGGC, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 Department of Clinical Physics and Bioengineering, NHSGGC, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 Academic Unit of Anaesthesia, Pain and Critical Care Medicine, University of Glasgow, Glasgow, UK. ISNI: 0000 0001 2193 314X. GRID: grid.8756.c Smartimplant Ltd., Tallinn, Estonia NEMC, Tallinn, Estonia. ISNI: 0000 0004 0631 377X. GRID: grid.454953.a Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a University of Manitoba, Winnipeg, Canada. ISNI: 0000 0004 1936 9609. GRID: grid.21613.37 Universite de Montreal, Montreal, Canada. ISNI: 0000 0001 2292 3357. GRID: grid.14848.31 University of British Columbia, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil Yonsei University College of Medicine, Seoul, South Korea. ISNI: 0000 0004 0470 5454. GRID: grid.15444.30 Emergency Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. ISNI: 0000 0001 2150 9058. GRID: grid.411439.a Morton Plant Hospital, Clearwater, USA. ISNI: 0000 0000 8602 0133. GRID: grid.416123.3 Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 Royal Cornwall Hospital Trust, Truro, UK. ISNI: 0000 0004 0474 4488. GRID: grid.412944.e Manchester Royal Infirmary, Manchester, UK. ISNI: 0000 0004 0641 2823. GRID: grid.419319.7 University of Tsukuba, Tsukuba Medical Center Hospital, Tsukuba, Japan. ISNI: 0000 0004 1764 0856. GRID: grid.417324.7 Kent, Surrey & Sussex Air Ambulance Trust, Kent, UK Prometheus Delta-Tech, Herefordshire, UK Stavanger University Hospital, Stavanger, Norway. ISNI: 0000 0004 0627 2891. GRID: grid.412835.9 Aseer Central Hospital, Abha, Saudi Arabia. ISNI: 0000 0004 0607 7156. GRID: grid.413974.c HagaZiekenhuis, Den Haag, Netherlands. ISNI: 0000 0004 0568 6689. GRID: grid.413591.b Reinier de Graaf Gasthuis, Delft, Netherlands. ISNI: 0000 0004 0624 5690. GRID: grid.415868.6 Santa Maria University Hospital, Lisboa, Portugal. ISNI: 0000 0001 2295 9747. GRID: grid.411265.5 St. Vincent’s University Hospital, Dublin 4, Ireland. ISNI: 0000 0001 0315 8143. GRID: grid.412751.4 Percy Military Teaching Hospital, Clamart, France Whiston Hospital, Prescot, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 King Abdulaziz Medical City, National Guard Hospital, Riyadh, Saudi Arabia. ISNI: 0000 0004 1790 7311. GRID: grid.415254.3 Department of Management, College of Business Administration, King Saud University, Saudi Arabia, Riyadh, Saudi Arabia. ISNI: 0000 0004 1773 5396. GRID: grid.56302.32 Ege University Hospital, Izmir, Turkey. ISNI: 0000 0004 0535 6364. GRID: grid.412190.f Katip Celebi University, Health Sciences Faculty, Izmir, Turkey Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK. GRID: grid.415667.7 Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 Specialist Anesthesia, Doha, Qatar University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 Christchurch Hospital, Christchurch, New Zealand. ISNI: 0000 0004 0614 1349. GRID: grid.414299.3 Clinical Center Ljubljana, Ljubljana, Slovenia. ISNI: 0000 0004 0571 7705. GRID: grid.29524.38 The Royal Marsden Hospital, London, UK. ISNI: 0000 0004 0417 0461. GRID: grid.424926.f Bogomolets National Medical University, Kiev, Ukraine. GRID: grid.412081.e Royal Liverpool Intensive Care Unit, Liverpool, UK Homerton University Hospital, London, UK. GRID: grid.439591.3 University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 University of Leicester, Leicester, UK. ISNI: 0000 0004 1936 8411. GRID: grid.9918.9 Research and Education Institute, Sao Paulo, Brazil Ipswich Hospital NHS Trust, England, UK, Ipswich, UK. ISNI: 0000 0004 0413 7370. GRID: grid.412930.d Phramongkutklao Hospital, Bangkok, Thailand. ISNI: 0000 0004 0576 1212. GRID: grid.414965.b Phramongkutklao College of Medicine, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 Pusan National University Hospital, Busan, South Korea. ISNI: 0000 0000 8611 7824. GRID: grid.412588.2 PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 The Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d PPG Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ISNI: 0000 0001 2294 473X. GRID: grid.8536.8 Hospital Esperanca Recife, Recife, Brazil Hospital Total Cor, Rio de Janeiro, Brazil Hospital viValle, São José dos Campos, Brazil Hospital Rios DOr, Rio de Janeiro, Brazil Hospital Norte DOr, Rio de Janeiro, Brazil Hospital Esperanca Olinda, Olinda, Brazil DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 Stamford Hospital, Stamford, USA. ISNI: 0000 0004 0377 0318. GRID: grid.416984.6 Darent Valley Hospital, Dartford, UK. ISNI: 0000 0004 0398 7314. GRID: grid.413475.0 St James’s University Hospital, Leeds, UK. GRID: grid.443984.6 Hospital Maciel, Montevideo, Uruguay. GRID: grid.414794.b Hospital de Cancer de Barretos, Barretos, Brazil. ISNI: 0000 0004 0615 7498. GRID: grid.427783.d Hospital Sírio Libanês, Sao Paulo, Brazil. ISNI: 0000 0000 9080 8521. GRID: grid.413471.4 Sta. Casa de Porto Alegre, Porto Alegre, Brazil University of Pittsburgh Medical Center, Pittsburgh, USA. ISNI: 0000 0001 0650 7433. GRID: grid.412689.0 Hospital Sao Lucas, Rio de Janeiro, Brazil Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b Instituto Português de Oncologia Francisco Gil - Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a Hôpital Bichat, Paris, France. ISNI: 0000 0000 8588 831X. GRID: grid.411119.d Abertawe Bro Morgannwg University Health Board, Swansea, UK. ISNI: 0000 0000 8959 0182. GRID: grid.419728.1 Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a Apollo Speciality Hospital - OMR, Chennai, India. ISNI: 0000 0004 1802 3550. GRID: grid.413839.4 Kingston General Hospital, Kingston, Canada. ISNI: 0000 0004 0633 727X. GRID: grid.415354.2 Milton Keynes Hospital, Milton Keynes, UK. GRID: grid.415667.7 Imperial College, London, UK. ISNI: 0000 0001 2113 8111. GRID: grid.7445.2 Buckinghamshire Healthcare NHS Trust, Aylesbury, UK. ISNI: 0000 0004 0368 863X. GRID: grid.439664.a IPO -Porto, Porto, Portugal. GRID: grid.435544.7 KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f Ernesto Dornelles Hospital, Porto Alegre, Brazil Gelre Ziekenhuizen, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 Surrey and Sussex NHS Trust, Redhill, UK Ege University School of Medicine, Izmir, Turkey. ISNI: 0000 0001 1092 2592. GRID: grid.8302.9 katip Celebi University, Izmir, Turkey. ISNI: 0000 0004 0454 9420. GRID: grid.411795.f Alexandria University Faculty of medicine, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 Fortis Escorts Heart Institute, New Delhi, India. ISNI: 0000 0004 1804 7827. GRID: grid.417966.b FMRI, Gurgaon, India. ISNI: 0000 0004 4653 2037. GRID: grid.464839.4 Philips Research North America, Cambridge, USA. GRID: grid.417285.d Hospital Sao Rafael, Salvador, Brazil. GRID: grid.413466.2 Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 St Helens and Knowsley, Liverpool, UK STH, Sheffield, UK Freeman Hospital, Newcastle upon Tyne, UK. ISNI: 0000 0004 0641 3308. GRID: grid.415050.5 Hospital Nove de Julho, Sao Paulo, Brazil University Hospital Coventry and Warwickshire, Coventry, UK. GRID: grid.15628.38 Sunnybrook Health Sciences Centre, Toronto, Canada. ISNI: 0000 0000 9743 1587. GRID: grid.413104.3 NHS Scotland, Glasgow, UK. ISNI: 0000 0000 9506 6213. GRID: grid.422655.2 Royal College of Surgeons of Ireland, Dublin, Ireland. ISNI: 0000 0004 0488 7120. GRID: grid.4912.e University Leiden, Leiden, Netherlands. ISNI: 0000 0001 2312 1970. GRID: grid.5132.5 Gelre Hospitals, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 VU University Amsterdam, Amsterdam, Netherlands. ISNI: 0000 0004 1754 9227. GRID: grid.12380.38 Hospital de Santo António, Oporto Hospital Center, Porto, Portugal Faculty of Psychology and Educational Sciences, Heerlen, Netherlands University of Toronto at Scarborough, Scarborough, ON Canada. ISNI: 0000 0001 2157 2938. GRID: grid.17063.33 University of Szeged, Szeged, Hungary. ISNI: 0000 0001 1016 9625. GRID: grid.9008.1 Jahn Ferenc Hospital, Budapest, Hungary University of Pécs, Pécs, Hungary. ISNI: 0000 0001 0663 9479. GRID: grid.9679.1 Hospital Clinico Universidad de Chile, Santiago, Chile. GRID: grid.412248.9 Royal Marsden Hospital, London, UK. ISNI: 0000 0004 0417 0461. GRID: grid.424926.f Centre Hospitalier de Lens, Lens, France. ISNI: 0000 0004 0642 1236. GRID: grid.470048.f Ntra Sra de Candelaria University Hospital, Santa Cruz de Tenerife, Spain University of Texas at Austin, San Antonio, USA. ISNI: 0000 0004 1936 9924. GRID: grid.89336.37 Beaumont Hospital, Dublin, Ireland. ISNI: 0000 0004 0617 6058. GRID: grid.414315.6 St Helens and Knowsley teaching hospitals, Liverpool, UK. GRID: grid.430747.3 Maastricht University Medical Center, Maastricht, Netherlands. GRID: grid.412966.e University Hospital Antwerp, Edegem, Belgium. ISNI: 0000 0004 0626 3418. GRID: grid.411414.5 University of Calgary, Calgary, Canada. ISNI: 0000 0004 1936 7697. GRID: grid.22072.35 Vrije Universiteit Brussel, Brussel, Belgium. ISNI: 0000 0001 2290 8069. GRID: grid.8767.e EMGO+/VU University medical center, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a Universitair Ziekenhuis Brussel, Brussel, Belgium. ISNI: 0000 0004 0626 3362. GRID: grid.411326.3 Lewisham & Greenwich NHS Trust, London, UK. GRID: grid.429537.e National Burn Unit, Montevideo, Uruguay St Elisabeth Ziekenhuis, Tilburg, Netherlands. GRID: grid.416373.4 Fondazione IRCCS Ca’ Granda - Ospedale maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 Istituto per lo Studio e la Prevenzione Oncologica, Florence, Italy. ISNI: 0000 0004 1758 0566. GRID: grid.417623.5 AN - 27885969 AU - Bateman, R. M. AU - Sharpe, M. D. AU - Jagger, J. E. AU - Ellis, C. G. AU - Solé-Violán, J. AU - López-Rodríguez, M. AU - Herrera-Ramos, E. AU - Ruíz-Hernández, J. AU - Borderías, L. AU - Horcajada, J. AU - González-Quevedo, N. AU - Rajas, O. AU - Briones, M. AU - Rodríguez de Castro, F. AU - Rodríguez Gallego, C. AU - Esen, F. AU - Orhun, G. AU - Ergin Ozcan, P. AU - Senturk, E. AU - Ugur Yilmaz, C. AU - Orhan, N. AU - Arican, N. AU - Kaya, M. AU - Kucukerden, M. AU - Giris, M. AU - Akcan, U. AU - Bilgic Gazioglu, S. AU - Tuzun, E. AU - Riff, R. AU - Naamani, O. AU - Douvdevani, A. AU - Takegawa, R. 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AU - Enguix-Armada, A. AU - Puerto-Morlan, A. AU - Perez-Valero, V. AU - Garcia-Alcantara, A. AU - Bolton, N. AU - Dudziak, J. AU - Bonney, S. AU - Tridente, A. AU - Nee, P. AU - Nicolaes, G. AU - Wiewel, M. AU - Schultz, M. AU - Wildhagen, K. AU - Horn, J. AU - Schrijver, R. AU - Van der Poll, T. AU - Reutelingsperger, C. AU - Pillai, S. AU - Davies, G. AU - Mills, G. AU - Aubrey, R. AU - Morris, K. AU - Williams, P. AU - Evans, P. AU - Gayat, E. G. AU - Struck, J. AU - Cariou, A. AU - Deye, N. AU - Guidet, B. AU - Jabert, S. AU - Launay, J. AU - Legrand, M. AU - Léone, M. AU - Resche-Rigon, M. AU - Vicaut, E. AU - Vieillard-Baron, A. AU - Mebazaa, A. AU - Arnold, R. AU - Capan, M. AU - Linder, A. AU - Akesson, P. AU - Popescu, M. AU - Tomescu, D. AU - Sprung, C. L. AU - Calderon Morales, R. AU - Munteanu, G. AU - Orenbuch-Harroch, E. AU - Levin, P. AU - Kasdan, H. AU - Reiter, A. AU - Volker, T. AU - Himmel, Y. AU - Cohen, Y. AU - Meissonnier, J. AU - Girard, L. AU - Rebeaud, F. 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Carvalho, C Velasco, I Kelly, J M Neill, A Rubenfeld, G Masson, N Min, A Boezeman, E Hofhuis, J Hovingh, A De Vries, R Cabral-Campello, G Van Mol, M Nijkamp, M Kompanje, E Ostrowski, P Kiss, K Köves, B Csernus, V Molnár, Z Hoydonckx, Y Vanwing, S Medo, V Galvez, R Miranda, J P Stone, C Wigmore, T Arunan, Y Wheeler, A Wong, Y Poi, C Gu, C Molmy, P Van Grunderbeeck, N Nigeon, O Lemyze, M Thevenin, D Mallat, J Correa, M Carvalho, R T Fernandez, A McBride, C Koonthalloor, E Walsh, C Webber, A Ashe, M Smith, K Dimitriadou, M Mantzafleri, P Vrani, O Arbouti, A Varsami, T Bollen, J A Van Smaalen, T C De Jongh, W C Ten Hoopen, M M Ysebaert, D Van Heurn, L W Van Mook, W N Roze des Ordons, A Couillard, P Doig, C Van Keer, R V Deschepper, R D Francke, A F Huyghens, L H Bilsen, J B Nyamaizi, B Dalrymple, C Dobru, A Marrinan, E Ankuli, A Struthers, R Crawford, R Morelli, P Degiovanangelo, M Lemos, F MArtinez, V Cabrera, J Rutten, A Van Ieperen, S De Geer, S Van Vugt, M Der Kinderen, E Giannini, A Miccinesi, G Marchesi, T Prandi, E Congress Overall Crit Care. 2016 Apr 20;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. PY - 2016 SN - 1364-8535 (Print) 1364-8535 SP - 94 ST - 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016 T2 - Crit Care TI - 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016 VL - 20 ID - 3980 ER - TY - JOUR AB - A case is presented of a transitional lumbosacral vertebra in a adolescent girl, presenting with low back pain. There was no evidence of a pars interarticularis defect. Careful assessment of children or adolescents presenting with low back pain is important since back pain in this age group is usually caused by organic disease. AU - Batt, M. E. AU - Skattum, N. AU - Chong, B. K. AU - Tanji, J. L. DA - 1996/12// DO - 10.1136/bjsm.30.4.356 DP - PubMed IS - 4 J2 - Br J Sports Med KW - Adolescent Female Gymnastics Humans Low Back Pain Lumbar Vertebrae Pseudarthrosis Radiography Radionuclide Imaging Spinal Fractures LA - eng PY - 1996 SN - 0306-3674 SP - 356-358 ST - Posterior element pain in a adolescent schoolgirl T2 - British Journal of Sports Medicine TI - Posterior element pain in a adolescent schoolgirl UR - http://www.ncbi.nlm.nih.gov/pubmed/9091138 VL - 30 ID - 129 ER - TY - JOUR AB - ObjectivesTo analyze the relation between the symptoms reported by adolescents with chronic tension-type headache (CTTH) and their perception of their emotional and behavioral functioning.MethodsTwo groups of adolescents (clinical group, n 48; control group, n 135) and their parents (clinical group, n 42; control group, n 128) were studied, respectively, with the Youth Self-Report Questionnaire and the Child Behavior Checklist. Moreover, a secondary analysis was performed, identifying another subgroup of adolescents who reported having headaches.ResultsThe clinical group of adolescents obtained higher scores than the control group in Internalizing Syndrome; Aggressive Behavior for Externalizing Syndrome; Social, Thought, and Attention Problems; and in all Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV)-oriented scales (except conduct problems). Differences between the two groups of parents were found in all the scales. The controls reporting headaches obtained interesting intermediate scores.ConclusionsAdolescents with CTTH show greater emotional and behavioral problems than their healthy peers. Consequently, clinical approaches for proper diagnosis and treatment need to adopt a multidisciplinary prospective. AN - WOS:000268331400002 AU - Battistutta, S. AU - Aliverti, R. AU - Montico, M. AU - Zin, R. AU - Carrozzi, M. DA - Aug DO - 10.1093/jpepsy/jsn102 IS - 7 N1 - Battistutta, Sara Aliverti, Renata Montico, Marcella Zin, Roberto Carrozzi, Marco Montico, Marcella/B-5290-2013 Montico, Marcella/0000-0003-0377-8232; Carrozzi, Marco/0000-0001-6282-4417 1465-735x PY - 2009 SN - 0146-8693 SP - 697-706 ST - Chronic Tension-Type Headache in Adolescents. Clinical and Psychological Characteristics Analyzed Through Self- and Parent-Report Questionnaires T2 - Journal of Pediatric Psychology TI - Chronic Tension-Type Headache in Adolescents. Clinical and Psychological Characteristics Analyzed Through Self- and Parent-Report Questionnaires UR - ://WOS:000268331400002 VL - 34 ID - 2597 ER - TY - JOUR AB - Introduction: Complex regional pain syndrome type 1 (CRPS I) in children differs from its adult counterpart and relevant literature is scarce. Our aim was to investigate potential risk factors and to assess midterm outcome and quality of life. Material and methods: Medical records of patients diagnosed with CRPS I between 2004 and 2012 were analyzed. Patients and parents were called for a phone interview including the PEDS Quality of Life 4-0 questionnaire. Results were compared to a control group matched for age, gender and socio-economic status. Results: Seventy-three patients were included (64 girls, 9 boys). Mean age at diagnosis was 11.5 years and mean time to diagnosis was 14.2 months. The lower limb was affected in 89% of cases. Allodynia, coldness and cyanosis were noted in 95%, 81% and of 74% of cases, respectively. Forty-nine percent of patients reported a physical injury. Multivariate analysis showed a strong association with being anxious (OR = 44.9, 95% CI [7.4-273]), presence of an atopic background (OR = 25.0, 95% CI: [4.6-135]), being good to excellent school performers (OR = 8.4 95% CI [1.3-52.1]), and having trouble falling asleep (OR = 5.3,95% CI [1.6-17.0]). At a mean 37 months' follow-up (12-102), PEDS QL 4-0 score was significantly lower in CRPS patients compared to controls. Fifty-seven percent of patients acknowledged healing and 55% had presented a relapse. Conclusion: Childhood onset CRPS I affects predominantly preadolescent girls at the ankle. The present study highlights the relatively poor outcome, especially its physical and emotional aspects and the large role of psychology. (C) 2015 Elsevier Masson SAS. All rights reserved. AN - WOS:000362985500017 AU - Bayle-Iniguez, X. AU - Audouin-Pajot, C. AU - de Gauzy, J. S. AU - Munzer, C. AU - Murgier, J. AU - Accadbled, F. DA - Oct DO - 10.1016/j.otsr.2015.06.013 IS - 6 N1 - Bayle-Iniguez, X. Audouin-Pajot, C. de Gauzy, J. Sales Munzer, C. Murgier, J. Accadbled, F. murgier, jerome/U-7387-2019 murgier, jerome/0000-0002-9237-1372 PY - 2015 SN - 1877-0568 SP - 745-748 ST - Complex regional pain syndrome type I in children. Clinical description and quality of life T2 - Orthopaedics & Traumatology-Surgery & Research TI - Complex regional pain syndrome type I in children. Clinical description and quality of life UR - ://WOS:000362985500017 VL - 101 ID - 2218 ER - TY - JOUR AB - Functional abdominal pain (FAP) is a common physical complaint in children and adolescents. Prior research has documented associations between FAP symptoms and mood, especially internalizing behaviors. Limited research is available examining the association between symptom burden and cognitive function in this pediatric population. This study explored associations between FAP symptoms, internalizing behaviors, and cognitive and school function in children and adolescents. Twenty-seven participants (mean age = 12.6 years, range 8.8-16.5; 33% male) diagnosed with FAP completed assessments of cognitive, emotional, and behavioral function, as well as FAP symptom severity. Mean performances on cognitive tests were within age-expected ranges. Within this context, however, higher overall burden of FAP symptoms was associated with slower processing speed, more self-reported metacognitive problems and internalizing behaviors, and more school absences. Cognitive function was systematically associated with internalizing behaviors but not physical symptoms. Overall, findings revealed that FAP may be associated with cognitive inefficiencies in addition to internalizing problems. Cognitive symptoms may be linked to internalizing behaviors associated with FAP. AN - WOS:000545795800001 AU - Bearden, D. J. AU - Waber, D. P. AU - Schreiber, J. E. AU - Mrakotsky, C. DO - 10.1080/21622965.2020.1758106 N1 - Bearden, Donald J. Waber, Deborah P. Schreiber, Jane E. Mrakotsky, Christine 2162-2973 SN - 2162-2965 ST - Functional abdominal pain symptom severity: Associations between cognition and emotion in a pediatric sample T2 - Applied Neuropsychology-Child TI - Functional abdominal pain symptom severity: Associations between cognition and emotion in a pediatric sample UR - ://WOS:000545795800001 ID - 1814 ER - TY - JOUR AB - Objective To provide a new approach for conceptualizing and studying functional somatic symptoms (FSS) in children and adolescence. Methods A developmental model is proposed based on the synthesis of the extant literature and previous theoretical perspectives of FSS in children and adolescents. Results Multiple risk and protective factors from child, familial, social, and environmental domains, the interactions across risk domains, and potential developmental pathways of FSS are identified. Conclusions This article underscores the necessity of taking a broader, developmental view of FSS. The tenets of developmental psychopathology emphasize the utility of viewing FSS on a continuum of severity rather than as a discrete entity or diagnosis. This article concludes with directions for future research and treatment implications. AN - WOS:000255757700009 AU - Beck, J. E. DA - Jun DO - 10.1093/jpepsy/jsm113 IS - 5 N1 - Beck, Joy E. 1465-735x PY - 2008 SN - 0146-8693 SP - 547-562 ST - A developmental perspective on functional somatic symptoms T2 - Journal of Pediatric Psychology TI - A developmental perspective on functional somatic symptoms UR - ://WOS:000255757700009 VL - 33 ID - 2649 ER - TY - JOUR AB - BACKGROUND: Although vocational rehabilitation is a widely advocated intervention for workers on sick leave due to subacute or chronic nonspecific musculoskeletal pain, the optimal dosage of effective and cost-effective vocational rehabilitation remains unknown. The objective of this paper is to describe the design of a non-inferiority trial evaluating the effectiveness and cost-effectiveness of 40-h multidisciplinary vocational rehabilitation compared with 100-h multidisciplinary vocational rehabilitation on work participation for workers on sick leave due to subacute or chronic musculoskeletal pain. METHODS/DESIGN: A non-inferiority study design will be applied. The study population consists of workers who are on part-time or full-time sick leave due to subacute or chronic nonspecific musculoskeletal pain. Two multidisciplinary vocational rehabilitation programs following the bio-psychosocial approach will be evaluated in this study: 40-h vocational rehabilitation and 100-h vocational rehabilitation, both delivered over a maximum of 15 weeks. The 100-h vocational rehabilitation comprises five modules: work participation coordination, graded activity, cognitive behavioral therapy, group education, and relaxation. The 40-h vocational rehabilitation comprises work participation coordination and a well-reasoned choice from the other four modules. Four rehabilitation centers will participate in this study, each delivering both interventions. Patients will be randomized into one of the interventions, stratified for the duration of sick leave (<6 weeks or ≥ 6 weeks) and type of sick leave (part-time or full-time). The primary outcome is work participation, measured by self-reported sick leave days, and will be assessed at baseline, mid-term, discharge, and at 2, 4, 6, 8, 10, and 12 months follow-up. Secondary outcomes are work ability, disability, quality of life, and physical functioning and will be assessed at baseline, discharge, and at 6 and 12 months follow-up. Cost outcomes are absenteeism, presenteeism, healthcare usage, and travelling costs. Cost-effectiveness will be evaluated from the societal and employer perspectives. DISCUSSION: The results obtained from this study will be useful for vocational rehabilitation practice and will provide stakeholders with relevant insights into two versions of vocational rehabilitation. TRIAL REGISTRATION: Dutch Trial Register identifier: NTR4362 (registered 17 March 2014). AD - Department of Rehabilitation Medicine, Center for Rehabilitation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. t.beemster@amc.uva.nl. Department of Research and Development, Heliomare Rehabilitation Center, Wijk aan Zee, The Netherlands. t.beemster@amc.uva.nl. Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. t.beemster@amc.uva.nl. Department of Research and Development, Heliomare Rehabilitation Center, Wijk aan Zee, The Netherlands. j.van.velzen@heliomare.nl. Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. j.van.velzen@heliomare.nl. Department of Research and Development, Heliomare Rehabilitation Center, Wijk aan Zee, The Netherlands. c.van.bennekom@heliomare.nl. Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. c.van.bennekom@heliomare.nl. Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.frings@uva.amc.nl. Department of Rehabilitation Medicine, Center for Rehabilitation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. m.f.reneman@cvr.umcg.nl. AN - 26215748 AU - Beemster, T. T. AU - van Velzen, J. M. AU - van Bennekom, C. A. AU - Frings-Dresen, M. H. AU - Reneman, M. F. C2 - PMC4518875 DA - Jul 28 DO - 10.1186/s13063-015-0861-4 DP - NLM ET - 2015/07/29 KW - Absenteeism Adolescent Adult Aged Chronic Pain/diagnosis/*economics/physiopathology/psychology/*rehabilitation Cognitive Behavioral Therapy/economics Cost-Benefit Analysis Female Group Processes *Health Care Costs Humans Male Middle Aged Musculoskeletal Pain/diagnosis/*economics/physiopathology/psychology/*rehabilitation Netherlands Occupational Health/*economics Patient Education as Topic/economics Rehabilitation, Vocational/*economics/methods Relaxation Therapy/economics Research Design Return to Work/*economics Sick Leave/*economics Time Factors Treatment Outcome Young Adult LA - eng N1 - 1745-6215 Beemster, Timo T van Velzen, Judith M van Bennekom, Coen A M Frings-Dresen, Monique H W Reneman, Michiel F Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Trials. 2015 Jul 28;16:317. doi: 10.1186/s13063-015-0861-4. PY - 2015 SN - 1745-6215 SP - 317 ST - Cost-effectiveness of 40-hour versus 100-hour vocational rehabilitation on work participation for workers on sick leave due to subacute or chronic musculoskeletal pain: study protocol for a randomized controlled trial T2 - Trials TI - Cost-effectiveness of 40-hour versus 100-hour vocational rehabilitation on work participation for workers on sick leave due to subacute or chronic musculoskeletal pain: study protocol for a randomized controlled trial VL - 16 ID - 3235 ER - TY - JOUR AB - BACKGROUND/AIMS:  Ventriculoperitoneal shunts (VPS) are a mainstay of treatment for hydrocephalus. Morbidity related to infection and dysfunction is well known, whereas data on psychosocial outcome and quality of life are scarce. Our aim was to assess headache burden and shunt-related impact on daily life in children growing up with a VPS. METHODS:  Patients between 3 and 21 years of age were identified and their families were contacted. A set of standardized questionnaires was used to assess headache and quality of life. RESULTS:  Fifteen patients with a mean age of 12 years agreed to participate in this study. Satisfaction with the VPS and improvement of the patient's condition was reported by 87%. A total of 67% denied negative impact on everyday life, reported a headache less than once a month, and never or rarely miss school. However, 53% take precautions before special activities. CONCLUSIONS:  The results demonstrate that modern VPS systems are tolerated very well and do not per se reduce quality of life. However, patients adapt to the presence of a VPS by avoiding risks and taking precautions. Chronic headache is not a major problem and not necessarily attributed to the VPS. Nevertheless, most patients asked for technical improvements, which might guide future research and the technical development of VPS. AD - Department of Neurosurgery, Medical Faculty, Heinrich-Heine-Universität, Düsseldorf, Germany. AN - 28962065 AU - Beez, T. AU - Bellstädt, L. AU - Steiger, H. J. AU - Sarikaya-Seiwert, S. DA - May DO - 10.1055/s-0037-1606852 DP - NLM ET - 2017/09/30 IS - 3 KW - *Activities of Daily Living Adolescent Child Child, Preschool Female Headache/*etiology Humans Hydrocephalus/*surgery Male Quality of Life Treatment Outcome Ventriculoperitoneal Shunt/*adverse effects Young Adult LA - eng N1 - 2193-6323 Beez, Thomas Bellstädt, Lina Steiger, Hans-Jakob Sarikaya-Seiwert, Sevgi Journal Article Germany J Neurol Surg A Cent Eur Neurosurg. 2018 May;79(3):196-199. doi: 10.1055/s-0037-1606852. Epub 2017 Sep 29. PY - 2018 SN - 2193-6315 SP - 196-199 ST - Headache and Shunt-Related Impact on Activities of Daily Life in Patients Growing Up with a Ventriculoperitoneal Shunt T2 - J Neurol Surg A Cent Eur Neurosurg TI - Headache and Shunt-Related Impact on Activities of Daily Life in Patients Growing Up with a Ventriculoperitoneal Shunt VL - 79 ID - 3907 ER - TY - JOUR AB - Low back pain (LBP) in children was considered for many years to be a rare condition revealing a serious disease, but in the last two decades, epidemiological studies have shown that the prevalence of nonspecific LBP in children is high. This study was aimed at analyzing the prevalence, severity, consequences and associated factors of LBP in children. A cross-sectional study was undertaken in two preparatory schools in the city of Monastir, Tunisia, in April 2002. This study included a total of 622 children and adolescents--326 females and 296 males--with a mean age of 14 years (range: 11-19 years). They completed the questionnaire in the presence of the physician. For the first 201 questionnaires collected, the corresponding children and adolescents underwent a spine medical examination, with evaluation of pain by visual analog scale if LBP was present. A stepwise logistic regression analysis was carried out to determine the risk factors associated with LBP and chronic LBP. The cumulative lifetime prevalence of LBP was 28.4%. Eight percent of the subjects suffered from chronic LBP. LBP was responsible for 23% of school absenteeism and 29% for sports absenteeism. Medical care requirement was observed in 32.2% and psychological symptoms in 75%. Stepwise logistic regression analysis showed that three factors were associated with LBP: school failure (held back 1 year), odds ratio (OR) =2.6 (95% confidence interval [CI], 1.96-3.44), family history of LBP (parental or sibling LBP), OR=3.80 (95% CI, 2.94-5.92), dissatisfaction with school chair (in height and comfort), OR=3.40 (95% CI, 2.24-5.29). Two factors were associated with chronic LBP: dissatisfaction with school chair, OR=1.62 (95% CI, 1.46-3.32) and football playing, OR=3.07 (95% CI, 2.15-5.10). The prevalence of LBP among Tunisian schoolchildren and adolescents is high. This requires preventive measures and longitudinal studies, which are very important from the standpoint of public health. AU - Bejia, Ismail AU - Abid, Nabiha AU - Ben Salem, Kamel AU - Letaief, Mondher AU - Younes, Mohamed AU - Touzi, Mongi AU - Bergaoui, Naceur DA - 2005/05// DO - 10.1007/s00586-004-0785-2 DP - PubMed IS - 4 J2 - Eur Spine J KW - Absenteeism Adolescent Child Cohort Studies Cross-Sectional Studies Delivery of Health Care Female Humans Low Back Pain Male Mental Health Pain Posture Prevalence Severity of Illness Index Tunisia LA - eng PY - 2005 SN - 0940-6719 SP - 331-336 ST - Low back pain in a cohort of 622 Tunisian schoolchildren and adolescents T2 - European Spine Journal: Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society TI - Low back pain in a cohort of 622 Tunisian schoolchildren and adolescents: an epidemiological study UR - http://www.ncbi.nlm.nih.gov/pubmed/15940479 VL - 14 ID - 111 ER - TY - JOUR AB - OBJECTIVES: The objective of this article is to determine the relationship between headache frequency and socio-demographic data, personal characteristics, habits, daily activities, daily loss of ability, depression and anxiety in the headache subtypes in the pediatric population. PATIENTS AND METHODS: Our sample group was composed of approximately 5355 children aged between 9 and 18 years. An eight-stage questionnaire was administered to the children. In the second stage of the study, headache subtypes were created according to the ICHD-II criteria. The resulting data were compared according to the results of the headache subtypes. RESULTS: In school-age children, the prevalence of recurrent headaches was 39.4%, and the prevalence of migraine was 10.3%. The subjects with migraine mostly preferred sedentary activities in their leisure time, and preferred less exercise than the subjects with the other headache types. The PedMIDAS score of the children who preferred to play sports was significantly lower than those who did not prefer to play sports. In the group that preferred reading books, an opposite relationship was found. In overweight and obese migraine sufferers, other types of headache were found to be significantly higher. CONCLUSIONS: In the management of treating childhood headaches, the association of psychiatric comorbidities should be considered. To minimize disability, children should be directed to more useful physical activities. AD - Department of Pediatric Neurology, Ankara University Medical School, Turkey bektasomer@gmail.com. Department of Child and Adolescent Psychiatry, Ankara University Medical School, Turkey. Department of Statistics, Ankara University Medical School, Turkey. Department of Pediatric Neurology, Ankara University Medical School, Turkey. AN - 25149505 AU - Bektaş, Ö AU - Uğur, C. AU - Gençtürk, Z. B. AU - Aysev, A. AU - Sireli, Ö AU - Deda, G. DA - May DO - 10.1177/0333102414547134 DP - NLM ET - 2014/08/26 IS - 6 KW - Adolescent Anxiety/psychology Child Cross-Sectional Studies Depression/psychology Feeding Behavior/psychology Female Headache/*epidemiology/*psychology Humans Leisure Activities/*psychology Male Prevalence Surveys and Questionnaires Turkey/epidemiology PedMIDAS Pediatric headache anxiety depression habits leisure time LA - eng N1 - 1468-2982 Bektaş, Ömer Uğur, Cağatay Gençtürk, Zeynep Bıyıklı Aysev, Ayla Sireli, Özlem Deda, Gülhis Journal Article England Cephalalgia. 2015 May;35(6):527-37. doi: 10.1177/0333102414547134. Epub 2014 Aug 22. PY - 2015 SN - 0333-1024 SP - 527-37 ST - Relationship of childhood headaches with preferences in leisure time activities, depression, anxiety and eating habits: A population-based, cross-sectional study T2 - Cephalalgia TI - Relationship of childhood headaches with preferences in leisure time activities, depression, anxiety and eating habits: A population-based, cross-sectional study VL - 35 ID - 3899 ER - TY - JOUR AB - Background Thirty percent of children with acute otitis media (AOM) experience symptoms < 7 days after initiating treatment, highlighting the importance of comprehensive discharge instructions. Methods We randomized caregivers of children 6 months to 17 years presenting to the emergency department (ED) with AOM to discharge instructions using a video on management of pain and fever to a paper handout. The primary outcome was the AOM Severity of Symptom (AOM-SOS) score at 72 hours postdischarge. Secondary outcomes included caregiver knowledge (10-item survey), absenteeism, recidivism, and satisfaction (5-item Likert scale). Results A total of 219 caregivers were randomized and 149 completed the 72-hour follow-up (72 paper and 77 video). The median (IQR) AOM-SOS score for the video was significantly lower than paper, even after adjusting for preintervention AOM-SOS score and medication at home (8 [7-11] vs. 10 [7-13], respectively; p = 0.004). There were no significant differences between video and paper in mean (+/- SD) knowledge score (9.2 [+/- 1.3] vs. 8.8 [+/- 1.8], respectively; p = 0.07), mean (+/- SD) number of children that returned to a health care provider (8/77 vs. 10/72, respectively; p = 0.49), mean (+/- SD) number of daycare/school days missed by child (1.2 [+/- 1.5] vs. 1.1 [+/- 2.1], respectively; p = 0.62), mean (+/- SD) number of workdays missed by caregiver (0.5 [+/- 1] vs. 0.8 [+/- 2], respectively; p = 0.05), or median (IQR) satisfaction score (5 [4-5] vs. 5 [4-5], respectively; p = 0.3). Conclusions Video discharge instructions in the ED are associated with less perceived AOM symptomatology compared to a paper handout. AN - WOS:000497067900001 AU - Belisle, S. AU - Dobrin, A. AU - Elsie, S. AU - Ali, S. AU - Brahmbhatt, S. AU - Kumar, K. AU - Jasani, H. AU - Miller, M. AU - Ferlisi, F. AU - Poonai, N. DO - 10.1111/acem.13839 N1 - Belisle, Sheena Dobrin, Andrei Elsie, Sharlene Ali, Samina Brahmbhatt, Shaily Kumar, Kriti Jasani, Hardika Miller, Michael Ferlisi, Frank Poonai, Naveen Ali, Samina/0000-0002-0595-364X 1553-2712 SN - 1069-6563 ST - Video Discharge Instructions for Acute Otitis Media in Children: A Randomized Controlled Open-label Trial T2 - Academic Emergency Medicine TI - Video Discharge Instructions for Acute Otitis Media in Children: A Randomized Controlled Open-label Trial UR - ://WOS:000497067900001 ID - 1872 ER - TY - JOUR AB - Introduction Headaches is a public health problem. Objective To assess the epidemiological and clinical features of headaches and their impact on the quality of life in schoolboys. Patients and Method It was a prospective study made in protestant college of Lome - Tokoin from September, 2007 to September, 2008, on 171 students. Results The average age was 14.56 +/- 2.45 years old, with 49.12% (84) of male and female in 50.88%(87). The primary headaches global prevalence was 84.62% (71) in boys and 86.15% (75) in girls. The tension headaches were founded in 41.52% followed by the migraine (39.77%) and symptomatic headaches (6.43%) on IHS criteria. The school bad performance was noted in 40.35%. An important and major repercussion of headaches on daily life was observed with respectively 9.36% and 33.92% on HIT-6 test. Three and IV degrees of handicap were noted with respectively 15.20% and 9.36% on MIDAS test. Conclusion Headaches is present in schoolboys with negative impact on their quality of life. A real care of headaches can help to improve school success. AN - WOS:000422487600004 AU - Belo, M. AU - Assogba, K. AU - Awidina-Ama, A. AU - Guinhouya, K. AU - Apetse, K. AU - Kombate, D. AU - Kumako, V. AU - Banakinao, Y. AU - Balogou, A. A. K. AU - Grunitzky, E. G. IS - 2 N1 - Belo, Mofou Assogba, Komi Awidina-Ama, Awissoba Guinhouya, Kokou Apetse, Kossi Kombate, Damelan Kumako, Vinyo Banakinao, Yao Balogou, Agnon Ayelola Koffi Grunitzky, Eric G. 1992-2647 PY - 2009 SN - 1015-8618 SP - 29-34 ST - HEADACHE AND QUALITY OF LIFE IN SCHOOLBOYS AT LOME, TOGO T2 - African Journal of Neurological Sciences TI - HEADACHE AND QUALITY OF LIFE IN SCHOOLBOYS AT LOME, TOGO UR - ://WOS:000422487600004 VL - 28 ID - 2620 ER - TY - JOUR AB - Dental caries is a common chronic disease that causes pain and disability across all age groups. If left untreated, dental caries can lead to pain and infection, tooth loss, and edentulism (total tooth loss). Dental sealants are effective in preventing dental caries in the occlusal (chewing) and other pitted and fissured surfaces of the teeth. Enamel fluorosis is a hypomineralization of enamel related to fluoride exposure during tooth formation (first 6 years for most permanent teeth). Exposure to fluoride throughout life is effective in preventing dental caries. This is the first CDC Surveillance Summary that addresses these conditions and practices. 1988-1994 and 1999-2002. The National Health and Nutrition Examination Survey (NHANES) is an ongoing survey of representative samples of the civilian, noninstitutionalized U.S. population aged >/=2 months in NHANES 1988-1994 and all ages during 1999-2002. The dental component gathered information on persons aged >/=2 years. During 1999-2002, among children aged 2-11 years, 41% had dental caries in their primary teeth. Forty-two percent of children and adolescents aged 6-19 years and approximately 90% of adults had dental caries in their permanent teeth. Among children aged 6-19 years, 32% had received dental sealants. Adults aged >/=20 years retained a mean of 24 of 28 natural teeth and 8% were edentulous. Among persons aged 6-39 years, 23% had very mild or greater enamel fluorosis. Disparities were noticed across all age groups, among racial/ethnic groups, persons with lower education and income, and by smoking status. From 1988-1994 to 1999-2002, four trends were observed: 1) no change in the prevalence of dental caries in primary teeth among children aged 2-11 years, 2) a reduction in prevalence of caries in permanent teeth of up to 10 percentage points among persons aged 6-19 years and up to six percentage points among dentate adults aged >/=20 years, 3) an increase of 13 percentage points in dental sealants among persons aged 6-19 years, and 4) a six percentage point reduction in total tooth loss (edentulism) among persons aged >/=60 years. The findings of this report indicate that the dental caries status of permanent teeth has improved since the 1988-1994 survey. Despite the decrease in caries prevalence and severity in the permanent dentition and the increase in the proportion of children and adolescents who benefit from dental sealants, disparities remain. These data provide information for public health professionals in designing interventions to improve oral health and to reduce disparities in oral health, for researchers in assessing factors associated with disparities and dental caries in primary teeth, and in designing timely surveillance tools to monitor total fluoride exposure. AU - Beltrán-Aguilar, Eugenio AU - Barker, Laurie AU - Canto, María AU - Dye, Bruce AU - Gooch, Barbara AU - Griffin, Susan AU - Hyman, Jeffrey AU - Jaramillo, Freder AU - Kingman, Albert AU - Nowjack-Raymer, Ruth AU - Selwitz, Robert AU - Wu, Tianxia DA - 2005/09/01/ DP - ResearchGate J2 - Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) PY - 2005 SP - 1-43 ST - Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis—United States, 1988-1994 and 1999-2002 T2 - Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) TI - Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis—United States, 1988-1994 and 1999-2002 VL - 54 ID - 2 ER - TY - JOUR AB - Background: Musculoskeletal pain (MSP) is a public health problem among school-adolescents. This study aimed to identify the prevalence, risk factors and consequences of neck, shoulders and low-back pain among school-adolescents. Study design: A cross-sectional study. Methods: School-adolescents aged from 12 to 18 years between October 2017 and February 2018 in South of Tunisia were recruited. Eligible participants were randomly selected and were asked to respond a four-section questionnaire. Factors independently associated with MSP were determined through multivariate logistic regression analysis. Results: Among 1221 enrolled subjects, shoulders, low-back and neck pain were reported in 43%, 35.8% and 32%, respectively. Multivariate analysis showed that independent risk factors of neck pain were female gender (Adjusted odds ratio AOR=1.55; P=0.002), using computer >= 4 hours/week (AOR=1.50; P=0.010), too low desk (AOR=2.30; P<0.001) and carrying schoolbag >= 60 minutes (AOR=1.58; P=0.008). Female gender (AOR=3.30; P<0.001), BMI >= 25 Kg/m(2) (AOR=1.6; P=0.018), playing videogames >= 2 hours/day (AOR=2.37; P<0.001) and schoolbag to body weight >= 10% (AOR=1.46; P=0.026) were independently associated with shoulders pain. For low back-pain, independent risk factors were high-school grade (AOR=2.70; P<0.001), playing videogames >= 2 hours/day (AOR=1.83; P<0.001), watching TV >= 12 hours/week (AOR=1.5; P=0.016), too low seat backrest (AOR=1.4; P=0.005) and too far seat-to-black (board) distance (AOR=1.5; P=0.041). School-adolescents consumed drugs for MSP in 19.5%, had sleep disturbance in 34% and aggressive behaviors in 22.8%. Conclusions: The prevalence of MSP was substantially high among school-adolescents and their associated risk factors included sociodemographic factors, leisure activities and classroom furniture. An ergonomic specific and behavior-based school program is urgently needed. AN - WOS:000467371000007 AU - Ben Ayed, H. AU - Yaich, S. AU - Trigui, M. AU - Ben Hmida, M. AU - Ben Jemaa, M. AU - Ammar, A. AU - Jedidi, J. AU - Karray, R. AU - Feki, H. AU - Mejdoub, Y. AU - Kassis, M. AU - Damak, J. C7 - e00440 DA - Win DO - 10.15171/jrhs.2019.07 IS - 1 N1 - Ben Ayed, Houda Yaich, Sourour Trigui, Maroua Ben Hmida, Mariem Ben Jemaa, Maissa Ammar, Achraf Jedidi, Jihene Karray, Raouf Feki, Habib Mejdoub, Yosra Kassis, Mondher Damak, Jamel Ammar, Achraf/B-8455-2018 Ammar, Achraf/0000-0003-0347-8053 2228-7809 PY - 2019 SN - 2228-7795 ST - Prevalence, Risk Factors and Outcomes of Neck, Shoulders and Low-Back Pain in Secondary-School Children T2 - Journal of Research in Health Sciences TI - Prevalence, Risk Factors and Outcomes of Neck, Shoulders and Low-Back Pain in Secondary-School Children UR - ://WOS:000467371000007 VL - 19 ID - 1871 ER - TY - JOUR AB - In a randomized, blinded study, we compared the outcome from a full-time functional restoration program with the outcome from shorter active rehabilitation programs for patients with chronic, disabling low back pain. The study initially included 132 patients, randomized into one of three treatment programs: (1) an intensive 3-week multidisciplinary program; (2) active physical training and back school; or (3) psychological pain management and active physical training. Nine of the randomized patients never started in any program, so the studied population consisted of 123 patients. Of these, 14 patients (11%) dropped out. The results presented here are at 1 year following treatment, where we achieved a 92% response rate, including the drop-outs. The functional restoration program was superior to the shorter programs as to work-ready rate, health care contacts, back pain level, disability level, staying physically active, and reduction in analgesics. There was no significant difference between Programs 2 and 3 in most of these parameters. As for sick leave and leg pain, there was no significant difference between Programs 1 and 2, although a difference was observed when comparing Program 3 with each of the other two. Conclusively, it seems that there is human, as well as economical, benefit from a functional restoration program compared to less intensive programs for these patients. AD - Copenhagen Back Centre, National University Hospital, Denmark. AN - 9198257 AU - Bendix, A. F. AU - Bendix, T. AU - Lund, C. AU - Kirkbak, S. AU - Ostenfeld, S. DA - Jun DP - NLM ET - 1997/06/01 IS - 2 KW - Adolescent Adult Chronic Disease Female Follow-Up Studies Humans Low Back Pain/*rehabilitation Male Middle Aged Prospective Studies Single-Blind Method Treatment Outcome LA - eng N1 - Bendix, A F Bendix, T Lund, C Kirkbak, S Ostenfeld, S Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Sweden Scand J Rehabil Med. 1997 Jun;29(2):81-9. PY - 1997 SN - 0036-5505 (Print) 0036-5505 SP - 81-9 ST - Comparison of three intensive programs for chronic low back pain patients: a prospective, randomized, observer-blinded study with one-year follow-up T2 - Scand J Rehabil Med TI - Comparison of three intensive programs for chronic low back pain patients: a prospective, randomized, observer-blinded study with one-year follow-up VL - 29 ID - 3474 ER - TY - CHAP A2 - Bobel, C. A2 - Winkler, I. T. A2 - Fahs, B. A2 - Hasson, K. A. A2 - Kissling, E. A. A2 - Roberts, T. A. AB - Benshaul-Tolonen et al. shine a light on two methodological issues impacting a research question that has received much attention recently: whether the provision of menstrual hygiene products reduces schoolgirls’ absenteeism in low-income countries. First, they identify bias in data sources, such as school records and recall data. Second, they show that limiting the focus to menstrual-related absenteeism obscures other threats that menstruation poses to educational attainment, health, and psychosocial well-being. To address these issues, the authors recommend the use of mixed methods, pre-analysis plans, and thoughtful consideration and validation of variables prior to study implementation. They also caution policymakers against overreliance on absenteeism as the sole outcome and overinterpreting results from existing studies that often lack scope and precision. They conclude with a call for more research on the links between menstruation and concentration, learning, self-esteem, and pain management. AD - Department of Women’s, Gender, and Sexuality Studies, University of Massachusetts Boston, Boston, MA, USA. GRID: grid.266685.9. ISNI: 0000 0004 0386 3207 Garden City Park, NY, USA Women and Gender Studies & Social and Cultural Analysis, Arizona State University, Glendale, AZ, USA. GRID: grid.215654.1. ISNI: 0000 0001 2151 2636 Center for Genetics and Society, Berkeley, CA, USA Women’s & Gender Studies, Eastern Washington University, Cheney, WA, USA. GRID: grid.255416.1. ISNI: 0000 0000 9067 4332 Department of Psychology, Colorado College, Colorado Springs, CO, USA. GRID: grid.254544.6. ISNI: 0000 0001 0657 7781 New York, NY, USA Liverpool, UK AN - 33347214 AU - Benshaul-Tolonen, A. AU - Zulaika, G. AU - Sommer, M. AU - Phillips-Howard, P. A. CY - Singapore DO - 10.1007/978-981-15-0614-7_52 LA - eng N1 - Bobel, Chris Winkler, Inga T Fahs, Breanne Hasson, Katie Ann Kissling, Elizabeth Arveda Roberts, Tomi-Ann Benshaul-Tolonen, Anja Zulaika, Garazi Sommer, Marni Phillips-Howard, Penelope A Review Book Chapter NBK565672 [bookaccession] PB - Palgrave Macmillan Copyright 2020, The Author(s). PY - 2020 SP - 705-23 ST - Measuring Menstruation-Related Absenteeism Among Adolescents in Low-Income Countries T2 - The Palgrave Handbook of Critical Menstruation Studies TI - Measuring Menstruation-Related Absenteeism Among Adolescents in Low-Income Countries ID - 4229 ER - TY - JOUR AB - BACKGROUND: Video-assisted thoracic surgery has recently evolved as a viable alternative to thoracotomy for spontaneous pneumothorax. METHODS: A series of 163 patients with primary spontaneous pneumothorax were treated by video-assisted thoracic surgery. Seventy patients were treated for a recurrent episode, 64 patients for a persistent primary spontaneous pneumothorax, 24 patients for a contralateral episode, and 5 patients for a bilateral primary spontaneous pneumothorax. Stapling of bullae with an Endo-GIA stapler (Auto-Suture, Elencourt, France) was performed in 90% of the cases and parietal pleural abrasion was performed in each case. RESULTS: One revisional lateral limited thoracotomy was required for bleeding. Six patients had a prolonged air leak; 2 of them were reoperated on by lateral limited thoracotomy. Two patients have had an incomplete reexpansion of the lung and required a reoperation. The duration of hospitalization was 6.9 +/- 3 days. With a mean follow-up of 24.5 months, three recurrences requiring a reoperation occurred; 3 other patients had a partial recurrence and healed by rest without drainage. The mean time to return to the occupational activity of the patients was 42 +/- 34 days. These results were compared with those of a previous series of 87 patients operated on by lateral limited thoracotomy. CONCLUSIONS: With the development of surgical technique and video equipment, video-assisted thoracic surgery will probably become the treatment of choice of primary spontaneous pneumothorax. AD - Department of Thoracic Surgery, Marie-Lannelongue Hospital, Le Plessis-Robinson, France. AN - 8651762 AU - Bertrand, P. C. AU - Regnard, J. F. AU - Spaggiari, L. AU - Levi, J. F. AU - Magdeleinat, P. AU - Guibert, L. AU - Levasseur, P. DA - Jun DO - 10.1016/0003-4975(96)00190-7 DP - NLM ET - 1996/06/01 IS - 6 KW - Absenteeism Adolescent Adult Case-Control Studies *Endoscopy/adverse effects Female Follow-Up Studies Hospitalization Humans Length of Stay Male Middle Aged Pain, Postoperative/etiology Pleura/surgery Pneumothorax/*surgery Postoperative Hemorrhage/surgery Recurrence Reoperation Retrospective Studies Surgical Staplers Surgical Stapling *Thoracoscopy/adverse effects Thoracotomy Treatment Outcome *Video Recording LA - eng N1 - Bertrand, P C Regnard, J F Spaggiari, L Levi, J F Magdeleinat, P Guibert, L Levasseur, P Comparative Study Journal Article Netherlands Ann Thorac Surg. 1996 Jun;61(6):1641-5. doi: 10.1016/0003-4975(96)00190-7. PY - 1996 SN - 0003-4975 (Print) 0003-4975 SP - 1641-5 ST - Immediate and long-term results after surgical treatment of primary spontaneous pneumothorax by VATS T2 - Ann Thorac Surg TI - Immediate and long-term results after surgical treatment of primary spontaneous pneumothorax by VATS VL - 61 ID - 3540 ER - TY - JOUR AB - Irritable bowel syndrome is a common functional gastrointestinal disorder that affects children and adults. The lack of consensus diagnostic criteria and pathophysiologic understanding has hampered clinical progress in diagnosing and treating this disorder. The recent development of the Rome diagnostic criteria, mapping of brain-gut pathways using neuroimaging, and serotonergic pharmacology have greatly advanced the field. Chronic and acute life stress, especially during childhood, has been recognized as central to the initiation of the disorder and the induction of acute symptoms. We propose a developmental continuum whereby the clinical presentation of irritable bowel syndrome changes with age from irritability during infancy, to diarrhea in toddlers, to recurring abdominal pain during school age, and to pain and altered bowel habits during later adolescence and adulthood. AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Memorial Hospital, 2300 Children's Plaza, #57, Chicago, IL 60614-3394, USA. AN - 15128493 AU - Besedovsky, A. AU - Li, B. U. DA - Jun DO - 10.1007/s11894-004-0015-4 DP - NLM ET - 2004/05/07 IS - 3 KW - Abdominal Pain/physiopathology Adult Child Diarrhea, Infantile/physiopathology Gastrointestinal Motility Humans Infant Irritable Bowel Syndrome/*diagnosis/drug therapy/epidemiology/*physiopathology Risk Factors LA - eng N1 - Besedovsky, Andres Li, B U K Journal Article Review United States Curr Gastroenterol Rep. 2004 Jun;6(3):247-53. doi: 10.1007/s11894-004-0015-4. PY - 2004 SN - 1522-8037 (Print) 1522-8037 SP - 247-53 ST - Across the developmental continuum of irritable bowel syndrome: clinical and pathophysiologic considerations T2 - Curr Gastroenterol Rep TI - Across the developmental continuum of irritable bowel syndrome: clinical and pathophysiologic considerations VL - 6 ID - 3944 ER - TY - JOUR AB - Objectives: The aim of this study is to determine the prevalence rate and impact of headache in school children on school attendance with particular attention to migraine. Methods: A cross sectional survey was conducted among the school children ranging from 6-17 years old over a period from March 2001 to April 2003. The study was carried out in 10 primary, preparatory and secondary schools. Subjects were selected by multistage stratified sampling procedure. This involved 851 children studying in the first to tenth year of school in the State of Qatar. Results: The present study showed that the prevalence rate of recurrent headache was 85% and migraine 11.9%. Comparing gender frequency of headache, it was noted that it was higher in female students (86.5%) than males (81%). In respect of age, it was observed that the oldest children had more frequent episodes of headache, the highest rate was in the age group of 11 - 15 years old (49%). The most common triggers were fatigue (35.8%) and lack of sleep (17.6%). The most common Symptoms that occurred before headache were change in mood for female students (39.1%) and blurred vision for males (34.6%). The impact of headache on children was frequent absence from school (80%), which affected their school performance. Conclusion: The current study indicated the high prevalence of headache among school children in Qatar, and its effect on school attendance and performance. AN - WOS:000229422200010 AU - Bessisso, M. S. AU - Bener, A. AU - Elsaid, M. F. AU - Al-Khalaf, F. A. AU - Huzaima, K. A. DA - Apr IS - 4 N1 - Bessisso, MS Bener, A Elsaid, MF Al-Khalaf, FA Huzaima, KA Bener, abdulbari/aac-4436-2020 PY - 2005 SN - 0379-5284 SP - 566-570 ST - Pattern of headache in school children in the State of Qatar T2 - Saudi Medical Journal TI - Pattern of headache in school children in the State of Qatar UR - ://WOS:000229422200010 VL - 26 ID - 2771 ER - TY - JOUR AB - OBJECTIVE: To identify prevalence and patterns of complementary and alternative medicine (CAM) use among youth with recurrent headaches (HA) and evaluate associations with co-occurring health problems and limitations as well as with the use and expenditures for conventional medical care. METHODS: Variables were constructed for youth aged 10 to 17 by using linked data from the 2007 National Health Interview Survey and the 2008 Medical Expenditures Panel Survey. Bivariate, logistic, and 2-part regression analyses were used. RESULTS: Of the 10.6% of youth experiencing HA, 29.6% used CAM, rising to 41% for the many HA sufferers who also experienced difficulties with emotions, concentration, behavior, school attendance, or daily activities. Biologically based products (16.2%) and mind-body therapies (13.3%) were most commonly used, especially by the 86.4% of youth with HA experiencing at least 1 other chronic condition. Compared with non-CAM users, youth with HA who used CAM also had higher expenditures for and use of most types of conventional care. CONCLUSIONS: CAM use is most common among youth with HA experiencing multiple chronic conditions and difficulties in daily functioning. Associations among CAM use, multiple chronic conditions, and higher use of conventional care highlight the need for medical providers to routinely ask about CAM use to meet the complex health needs of their patients and facilitate the optimal integration of care. Research is needed to identify models for coordinating complementary and conventional care within a medical home and to understand the health benefits or risks associated with CAM use in conjunction with conventional treatments for patients with HA. AN - WOS:000326475000008 AU - Bethell, C. AU - Kemper, K. J. AU - Gombojav, N. AU - Koch, T. K. DA - Nov DO - 10.1542/peds.2013-1816 IS - 5 N1 - Bethell, Christina Kemper, Kathi J. Gombojav, Narangerel Koch, Thomas K. 1098-4275 PY - 2013 SN - 0031-4005 SP - E1173-E1183 ST - Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches T2 - Pediatrics TI - Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches UR - ://WOS:000326475000008 VL - 132 ID - 2338 ER - TY - JOUR AB - Purpose To report evidence of chronic physical illnesses, mental health disorders, and psychological features as potential risk factors for back pain in children, adolescents, and young adults. Methods This systematic review and meta-analysis included cohort and inception cohort studies that investigated potential risk factors for back pain in young people. Potential risk factors of interest were chronic physical illnesses, mental health disorders (e.g. depression, anxiety), and other psychological features (e.g. coping, resistance). Searches were conducted in MEDLINE, Embase, CINAHL, and Scopus from inception to July 2019. Results Nineteen of 2167 screened articles were included in the qualitative synthesis, and data from 12 articles were included in the meta-analysis. Evidence from inception cohort studies demonstrated psychological distress, emotional coping problems, and somatosensory amplification to be likely risk factors for back pain. Evidence from non-inception cohort studies cannot distinguish between risk factors or back pain triggers. However, we identified several additional factors that were associated with back pain. Specifically, asthma, headaches, abdominal pain, depression, anxiety, conduct problems, somatization, and 'feeling tense' are potential risk factors or triggers for back pain. Results from the meta-analyses demonstrated the most likely risk factors for back pain in young people are psychological distress and emotional coping problems. Conclusion Psychological features are the most likely risk factors for back pain in young people. Several other factors were associated with back pain, but their potential as risk factors was unclear due to risk of bias. Additional high-quality research is needed to better elucidate these relationships. Graphic abstract These slides can be retrieved under Electronic Supplementary Material. AN - WOS:000519664000011 AU - Beynon, A. M. AU - Hebert, J. J. AU - Hodgetts, C. J. AU - Boulos, L. M. AU - Walker, B. F. DA - Mar DO - 10.1007/s00586-019-06278-6 IS - 3 N1 - Beynon, Amber M. Hebert, Jeffrey J. Hodgetts, Christopher J. Boulos, Leah M. Walker, Bruce F. Hodgetts, Christopher/0000-0001-6474-8155; Hebert, Jeffrey/0000-0002-6959-325X; Boulos, Leah/0000-0002-9849-383X; Walker, Bruce/0000-0002-8506-6740; Beynon, Amber/0000-0002-1302-4429 1432-0932 PY - 2020 SN - 0940-6719 SP - 480-496 ST - Chronic physical illnesses, mental health disorders, and psychological features as potential risk factors for back pain from childhood to young adulthood: a systematic review with meta-analysis T2 - European Spine Journal TI - Chronic physical illnesses, mental health disorders, and psychological features as potential risk factors for back pain from childhood to young adulthood: a systematic review with meta-analysis UR - ://WOS:000519664000011 VL - 29 ID - 1838 ER - TY - JOUR AB - The social and demographic characteristics of similar to 65,000 Tibetan refugees in India were determined from data collected 1994-1996. Approximately 55,000 refugees were living in 37 settlements widely distributed around India. The remaining 10,000 refugees were monks living in monasteries associated with some of the settlements. mostly in the south of India. In the settlements, a community-based surveillance system was established and data were collected by trained community health workers in house to house visits. In the monasteries, data were collected by the community health workers in monthly interviews with a designated liaison monk at each monastery. These data indicated little immigration of new civilian refugees in the past 10 years into the settlements but a steady influx of new monks into the monasteries. The age distribution in the settlements showed a prominent mode in the 15-25 year age range, a declining birth rate, and an increasing proportion of elderly. In general, refugees born in India were educated through secondary school, while refugees born in Tibet were often illiterate. The principle occupations were education involving 27% (including students), farming, 16%, and sweater selling, 6.5%: another 6.5% were too young or too old for employment, and only 2.4% were unemployed. The overall crude birth rate was determined to be relatively low at 16.8/1000, although this may underestimate the true figure. Infant mortality varied from 20 to 3511000 live births in the different regions. Child vaccination programs cover less than 50% of the population. The burden of illness in this society was mainly characterized by diarrhoea, skin infections, respiratory infections, fevers, and, among the elderly, joint pains and cardiovascular problems. Although calculated death rates were unrealistically low, due to under-reporting, causes of death, derived from "verbal autopsies", were mainly cancer, tuberculosis, accidents, cirrhosis and heart disease in order of decreasing frequency. Overall. the sociodemographic and health characteristics of this population appear to be in transition from those typical of the least developed countries to those typical of middle income and more affluent societies. (C) 2002 Elsevier Science Ltd. All rights reserved. AN - WOS:000173266800009 AU - Bhatia, S. AU - Dranyi, T. AU - Rowley, D. DA - Feb DO - 10.1016/s0277-9536(01)00040-5 IS - 3 N1 - Bhatia, S Dranyi, T Rowley, D PY - 2002 SN - 0277-9536 SP - 411-422 ST - A social and demographic study of Tibetan refugees in India T2 - Social Science & Medicine TI - A social and demographic study of Tibetan refugees in India UR - ://WOS:000173266800009 VL - 54 ID - 2837 ER - TY - JOUR AB - BACKGROUND: Functional gastrointestinal diseases (FGIDs) are emerging as an important cause of morbidity in adolescents globally. The prevalence of FGIDs among Indian children or adolescents is not clear. METHODS: A cross-sectional school-based survey conducted in 1115 children aged 10-17 years attending four semi urban government schools of National capital territory (NCT) of Delhi. Rome III questionnaire was translated into Hindi and was filled by the students under supervision. Prevalence of FGIDs was calculated. RESULTS: Ten percent (112) adolescents had FGIDs. Out of 112, 52 % (58) were boys, and 48 % (54) were girls. 2.7 % (30) had functional dyspepsia, 1.3 % (15) had irritable bowel syndrome, 1.4 % (16) had abdominal migraine, 1.5 % (17) had aerophagia, 0.4 % (5) had functional abdominal pain syndrome, and 0.3 % (4) had functional abdominal pain. Prevalence of functional constipation, adolescent rumination syndrome, cyclical vomiting syndrome, and non-retentive fecal incontinence were 0.5 % (6), 0.3 % (4), 0.3 % (3), 0.4 % (5), respectively. Functional abdominal pain-related FGID were present in 6.3 % (70) children (35 boys and 35 girls). Functional constipation (4 vs. 2) and functional abdominal pain syndrome (4 vs. 1, p < 0.05) were significantly more in females. CONCLUSIONS: The prevalence of functional gastrointestinal disorders in our study was 10 %. The most frequent FGID noted was functional dyspepsia. AD - Apollo Centre for Advanced Pediatrics, Indraprastha Apollo Hospital, Sarita Vihar, Delhi Mathura Road, New Delhi, 110 076, India. Department of Pediatrics, PGIMER and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, 110 001, India. shivanipaeds@gmail.com. AN - 27554498 AU - Bhatia, V. AU - Deswal, S. AU - Seth, S. AU - Kapoor, A. AU - Sibal, A. AU - Gopalan, S. DA - Jul DO - 10.1007/s12664-016-0680-x DP - NLM ET - 2016/08/25 IS - 4 KW - Adolescent Age Factors Child Cross-Sectional Studies Dyspepsia/epidemiology Female Gastrointestinal Diseases/*epidemiology Humans India/epidemiology Male Morbidity Prevalence Schools/*statistics & numerical data Adolescent health Functional disorders Gastroenterology School health LA - eng N1 - 0975-0711 Bhatia, Vidyut Deswal, Shivani Seth, Swati Kapoor, Akshay Sibal, Anupam Gopalan, Sarath Journal Article India Indian J Gastroenterol. 2016 Jul;35(4):294-8. doi: 10.1007/s12664-016-0680-x. Epub 2016 Aug 24. PY - 2016 SN - 0254-8860 SP - 294-8 ST - Prevalence of functional gastrointestinal disorders among adolescents in Delhi based on Rome III criteria: A school-based survey T2 - Indian J Gastroenterol TI - Prevalence of functional gastrointestinal disorders among adolescents in Delhi based on Rome III criteria: A school-based survey VL - 35 ID - 3803 ER - TY - JOUR AB - Dysmenorrhea is the most common of gynecologic complaints. It affects half of all female adolescents today and represents the leading cause of periodic college/school absenteeism among that population. To evaluate the menstrual problem specially dysmenorrhea and its severity in female medical students and its effect on their regular activities. They affect 80% of women at some time in their lives; usually they are not assigning of a serious underlying problems. It is a condition where there will be painful menstruation associated with abdominal cramps, backache, nausea and vomiting, stiffness in thighs, cramps in calf muscles. Pain usually last for 2 or 3 days and tends to happen in the first few days of the period. Up to 15% of women have period pains, severe enough to interfere with their daily activities. This can lead to missing days at work or diseased participation in social or sporting activities. Dysmenorrhea is of two type namely primary and secondary dysmenorrhoea. Primary dysmenorrhoea is used to describe normal period pain experienced by many women during the time of their period and there is no underlying medical problem. Secondary dysmenorrhoea is used to describe pain results of an underlying gynecological problem. There are number of measures like sitz bath, simple morning walk and dietotherapy. There are number of herbal drugs mentioned in Unani literature which are useful in tackling this problem. The review highlights about dysmenorrhoea and some of those herbal drugs which are used in Unani System of medicine. AN - WOS:000218687700006 AU - Bhatl, S. A. AU - Raza, A. AU - ParasWani AU - Shahbuddin DA - Jan IS - 1 N1 - Bhatl, Shabir Ahmad Raza, Aysha ParasWani Shahbuddin PY - 2015 SN - 2349-7750 SP - 539-542 ST - CONCEPT AND MANAGEMENT OF DYSMENORRHEA IN UNANI SYSTEM OF MEDICINE T2 - Indo American Journal of Pharmaceutical Sciences TI - CONCEPT AND MANAGEMENT OF DYSMENORRHEA IN UNANI SYSTEM OF MEDICINE UR - ://WOS:000218687700006 VL - 2 ID - 2265 ER - TY - JOUR AB - A boy aged 10 is assigned on a diagnosis of migraine and allergy. While numerous studies have confirmed the effect of acupuncture in case of tension headache or migraine, allergy as well apparently responds to needling. In individual studies effectiveness in children with cephalea was proven, too. Is classical acupuncture suitable for successful treatment of children? Two experts present different approaches to painless and yet effective treatment of school children. AN - WOS:000358086100009 AU - Bijak, M. AU - Stockert, K. AU - Wernicke, T. DO - 10.1016/s0415-6412(15)30012-6 IS - 2 N1 - Bijak, M. Stockert, K. Wernicke, T. 1439-4359 PY - 2015 SN - 0415-6412 SP - 31-33 ST - Child with headache and allergy T2 - Deutsche Zeitschrift Fur Akupunktur TI - Child with headache and allergy UR - ://WOS:000358086100009 VL - 58 ID - 2258 ER - TY - JOUR AB - Sickle cell disease (SCD), an inherited blood disorder that primarily affects individuals of African descent, is associated with serious medical complications as well as numerous social-environmental risk factors. These social-environmental factors are linked to long-standing social inequities, such as financial hardship and racial discrimination, both of which impact cognitive and behavioral functioning in youth. Previous research on the relationship between social-environmental risk and psychological functioning has primarily relied on non-modifiable, unidimensional measures of socioeconomic status (SES), such as income and parental education, as a proxy for social-environmental risk. The current study aimed to address the limitations associated with typical SES-type measures by comparing the unique and shared association of SES and more targeted and modifiable social-environmental factors (e.g., parent and family functioning) with specific areas of cognitive and behavioral adjustment in pediatric SCD. Seventy children ages 4-8 years old and their parents completed measures of social-environmental risk and psychological adjustment. Exploratory factor analysis indicated parent and family functioning measures were largely independent of SES. Parent and family functioning predicted phonological processing and ADHD symptoms above and beyond SES alone. In addition, the predictive ability of social-environmental risk factors appears to vary by genotype severity for measures of social functioning and math problem-solving ability. Future studies are needed to explore more specific and well-supported models of modifiable social-environmental risk and the relative impact of social-environmental risk on cognitive and behavioral functioning. AN - WOS:000586020700006 AU - Bills, S. E. AU - Schatz, J. AU - Hardy, S. J. AU - Reinman, L. DA - Jan DO - 10.1080/09297049.2019.1577371 IS - 1 N1 - Bills, Sarah E. Schatz, Jeffrey Hardy, Steven J. Reinman, Laura Hardy, Steven/0000-0002-0491-4980; Schatz, Jeffrey/0000-0002-5129-2344 1744-4136 PY - 2020 SN - 0929-7049 SP - 83-99 ST - Social-environmental factors and cognitive and behavioral functioning in pediatric sickle cell disease T2 - Child Neuropsychology TI - Social-environmental factors and cognitive and behavioral functioning in pediatric sickle cell disease UR - ://WOS:000586020700006 VL - 26 ID - 1850 ER - TY - JOUR AB - BACKGROUND: Chronic pain affects 1-3 million Canadian children and adolescents and their families. The primary objective of the Partnering For Pain project was to collaboratively identify the top 10 research priorities in pediatric chronic pain. METHODS: Partnering For Pain took a patient-oriented research approach and followed a modified James Lind Alliance Priority Setting Partnership (PSP) to identify the top research priorities in pediatric chronic pain according to people with lived experience (patients), family members and health care providers (clinicians). The PSP was completed in 4 phases between May and December 2018: 1) national survey of stakeholders, including those with lived experience with pediatric chronic pain, family members and clinicians who treat children with chronic pain, to gather priorities, 2) data processing, 3) interim prioritization by invited patients, family members and clinicians (former research participants or identified through pediatric chronic pain programs, patient partner organizations and steering committee member networks) and 4) in-person priority-setting workshop involving patients, family members and clinicians identified via steering committee networks and partner organizations, with evaluation of patient engagement. The process was led by a national steering committee of patient and parent partners, researchers and clinicians engaged in codesign, analysis and translation of project findings. RESULTS: In phase 1, 215 Canadians (86 patients [40.0%], 56 family members [26.0%] and 73 clinicians [34.0%]) submitted 540 potential priorities that were developed into 112 unique research questions (phase 2). Of the 112 questions, 63 were rated for importance by 57 participants (19 patients [33%], 17 family members [30%] and 21 clinicians [37%]) in phase 3. In phase 4, 20 participants (6 patients [30%], 6 family members [30%] and 8 clinicians [40%]) discussed the 25 most highly rated questions and reached consensus on the final top 10. INTERPRETATION: The final priorities address pediatric chronic pain prevention, impact and treatment, as well as delivery, access and coordination of care. The priorities reflect a directed and collaborative call to action to improve existing pediatric pain research and care. PLAIN LANGUAGE SUMMARY: Chronic pain affects 1 in 5 children and teens. This means that 1-3 million Canadian youth deal with pain lasting months to years. This pain gets in the way of being active, sleeping, going to school, and getting along with friends and family. Youth with chronic pain and their families are experts on what it's like to live with pain, but, until now, research has not asked what issues they care about most. The goal of the Partnering For Pain project was to develop a list of the 10 most important things we still need to learn about chronic pain during childhood according to people who live with it, their families and health care providers. We did this in 4 steps: 1) a survey with 215 people who shared 540 concerns they have about chronic pain in childhood, 2) turning those concerns into questions that can be answered by research, 3) a survey with 57 people who ranked how important each research question was and 4) an in-person discussion with 20 people who chose the top 10 research priorities. Each step included Canadians who have had chronic pain during childhood, their families and health care providers. The final top 10 list has questions about how to better prevent and care for children and teens with chronic pain. These priorities make sure that future research focuses on what is most important to people who will use it in their everyday lives. Project video: https://youtu.be/wA-RwrFiSPk. Project website: www.partneringforpain.com. AD - University of Toronto and The Hospital for Sick Children (Birnie, Stinson), Toronto, Ont.; patient partner (K. Dib, M. Dib), Halifax, NS; patient partner (Ouellette), McMaster University, Hamilton, Ont.; parent partner (Nelson), Windsor, Ont.; parent partner (Pahtayken), Onion Lake, Sask.; Department of Pediatrics (Baerg), University of Saskatchewan, Saskatoon, Sask.; Dalhousie University and IWK Health Centre (Chorney), Halifax, NS; University of Ottawa (Forgeron, Lamontagne, Poulin); Children's Hospital of Eastern Ontario (Lamontagne), Ottawa, Ont.; University of Calgary (Noel), Calgary, Alta.; The Ottawa Hospital (Poulin), Ottawa, Ont. kathryn.birnie@sickkids.ca. University of Toronto and The Hospital for Sick Children (Birnie, Stinson), Toronto, Ont.; patient partner (K. Dib, M. Dib), Halifax, NS; patient partner (Ouellette), McMaster University, Hamilton, Ont.; parent partner (Nelson), Windsor, Ont.; parent partner (Pahtayken), Onion Lake, Sask.; Department of Pediatrics (Baerg), University of Saskatchewan, Saskatoon, Sask.; Dalhousie University and IWK Health Centre (Chorney), Halifax, NS; University of Ottawa (Forgeron, Lamontagne, Poulin); Children's Hospital of Eastern Ontario (Lamontagne), Ottawa, Ont.; University of Calgary (Noel), Calgary, Alta.; The Ottawa Hospital (Poulin), Ottawa, Ont. AN - 31699686 AU - Birnie, K. A. AU - Dib, K. AU - Ouellette, C. AU - Dib, M. A. AU - Nelson, K. AU - Pahtayken, D. AU - Baerg, K. AU - Chorney, J. AU - Forgeron, P. AU - Lamontagne, C. AU - Noel, M. AU - Poulin, P. AU - Stinson, J. C2 - PMC6839970 DA - Oct-Dec DO - 10.9778/cmajo.20190060 DP - NLM ET - 2019/11/09 IS - 4 LA - eng N1 - 2291-0026 Birnie, Kathryn A Dib, Katherine Ouellette, Carley Dib, Mary Anne Nelson, Kimberly Pahtayken, Dolores Baerg, Krista Chorney, Jill Forgeron, Paula Lamontagne, Christine Noel, Melanie Poulin, Patricia Stinson, Jennifer Journal Article CMAJ Open. 2019 Nov 7;7(4):E654-E664. doi: 10.9778/cmajo.20190060. Print 2019 Oct-Dec. PY - 2019 SN - 2291-0026 (Print) 2291-0026 SP - E654-e664 ST - Partnering For Pain: a Priority Setting Partnership to identify patient-oriented research priorities for pediatric chronic pain in Canada T2 - CMAJ Open TI - Partnering For Pain: a Priority Setting Partnership to identify patient-oriented research priorities for pediatric chronic pain in Canada VL - 7 ID - 4025 ER - TY - JOUR AB - Poor access to pediatric chronic pain care is a longstanding concern. The COVID-19 pandemic has necessitated virtual care delivery at an unprecedented pace and scale. We conducted a scoping review to create an interactive Evidence and Gap Map (EGM) of virtual care solutions across a stepped care continuum (i.e., from self-directed to specialist care) for youth with chronic pain and their families. Review methodology was co-designed with 8 youth with chronic pain and 7 parents/caregivers. Data sources included peer-reviewed scientific literature, grey literature (app stores, websites), and a call for innovations. Records were independently coded and assessed for quality. Overall, 185 records were included (105 scientific records, 56 apps, 16 websites, and 8 innovations). Most virtual care solutions were applicable across pediatric chronic pain diagnoses, with the greatest proportion at lower levels of stepped care (i.e., >100 self-guided apps and websites). Virtual delivery of psychological strategies was common. Evidence gaps were noted at higher levels of stepped care (i.e., requiring more resource and health professional involvement), integration with health records, communication with health professionals, web accessibility, and content addressing social/family support, medications, school, substance use, sleep, diet, and acute pain flares or crises. EGMs are a novel visual knowledge synthesis tool that enable rapid evidence-informed decision-making by patients and families, health professionals, and policymakers. This EGM identified high quality virtual care solutions for immediate scale and spread, and areas with no evidence in need of prioritization. Virtual care should address priorities identified by youth with chronic pain and their families. AD - Department of Anesthesiology, Perioperative and Pain Medicine, University of Calgary, Calgary, AB, Canada Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada Alberta Children's Hospital Research Institute, Calgary, AB, Canada Solutions for Kids in Pain (SKIP), Halifax, NS, Canada Department of Psychology, University of Calgary, Calgary, AB, Canada Northern Ontario School of Medicine, Thunder Bay, ON, Canada Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada Lawrence S. Bloomberg, Faculty of Nursing, University of Toronto, Toronto, ON, Canada Health Sciences Library & Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada Department of Anesthesia & Pain Medicine, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada. AN - 34050111 AU - Birnie, K. A. AU - Pavlova, M. AU - Neville, A. AU - Noel, M. AU - Jordan, I. AU - Jordan, E. AU - Marianayagam, J. AU - Stinson, J. AU - Lorenzetti, D. L. AU - Faulkner, V. AU - Killackey, T. AU - Campbell, F. AU - Lalloo, C. DA - May 28 DO - 10.1097/j.pain.0000000000002339 DP - NLM ET - 2021/05/30 LA - eng N1 - 1872-6623 Birnie, Kathryn A Pavlova, Maria Neville, Alexandra Noel, Melanie Jordan, Isabel Jordan, Evie Marianayagam, Justina Stinson, Jennifer Lorenzetti, Diane L Faulkner, Violeta Killackey, Tieghan Campbell, Fiona Lalloo, Chitra Journal Article United States Pain. 2021 May 28. doi: 10.1097/j.pain.0000000000002339. PY - 2021 SN - 0304-3959 ST - Rapid evidence and gap map of virtual care solutions across a stepped care continuum for youth with chronic pain and their families in response to the COVID-19 pandemic T2 - Pain TI - Rapid evidence and gap map of virtual care solutions across a stepped care continuum for youth with chronic pain and their families in response to the COVID-19 pandemic ID - 4071 ER - TY - JOUR AB - BACKGROUND: The comorbidity of headache and psychiatric symptoms is a well-recognized clinical phenomenon, but there are only limited data regarding the temporal relationship between headache and symptoms of anxiety and depression as well as behavioral problems in adolescents. This study investigates the relationship of anxiety and depressive symptoms and behavioral problems at baseline with recurrent headache at follow-up four years later. METHODS: Within the Nord-Trøndelag Health Study (HUNT), including repeated population-based studies conducted in Norway, 2399 adolescents in junior high schools aged 12-16 years (77% of the invited) participated in Young-HUNT1 (1995-1997) and again at follow-up four years later, in Young-HUNT2 (2000-2001). The same comprehensive questionnaire that included assessment of symptoms of anxiety and depression and behavioral problems, i.e. conduct and attention difficulties was completed in both studies. In addition 1665 of the participants were interviewed about their headache complaints in Young-HUNT2. RESULTS: In adjusted multivariate analyses we found that higher scores of anxiety and depressive symptoms at baseline were associated with recurrent headache at follow-up four years later (OR: 1.6, 95% CI: 1.2-2.1, p = 0.001), evident for migraine (OR: 1.8, 95% CI: 1.2-2.7, p = 0.008) and non-classifiable headache (OR: 1.7, 95% CI: 1.0-2.8, p = 0.034), but not statistically significant for tension-type headache (OR: 1.4, 95% CI: 1.0-1.9, p = 0.053). Higher scores of anxiety and depressive symptoms at baseline were significantly associated with more frequent headache at follow-up (monthly vs. no recurrent headache OR: 1.8, 95% CI: 1.3-2.5, p = 0.001, weekly or daily vs. no recurrent headache OR: 1.9, 95% CI: 1.2-2.9, p = 0.005). Among adolescents without recurrent headache at baseline, higher scores for symptoms of anxiety and depression were associated with new onset migraine four years later (OR: 2.6, 95% CI: 1.1-4.8, p = 0.036). Higher scores of attention problems at baseline were associated with non-classifiable headache at follow-up (OR: 2.0, 95% CI: 1.3-3.4, p = 0.017). CONCLUSIONS: Results from the present study showed that symptoms of anxiety and depression in early adolescence were associated with recurrent headache four years later. Recognizing anxiety and depressive symptoms should be considered part of the clinical assessment in young headache patients, as early identification of these associated factors may lead to improved headache management. AD - Department of Neurology, Vestfold Hospital, Tønsberg, Norway. britaj@mac.com. AN - 25595046 AU - Blaauw, B. A. AU - Dyb, G. AU - Hagen, K. AU - Holmen, T. L. AU - Linde, M. AU - Wentzel-Larsen, T. AU - Zwart, J. A. C2 - PMC4405520 DA - Jan 16 DO - 10.1186/1129-2377-16-10 DP - NLM ET - 2015/01/18 KW - Adolescent *Adolescent Behavior/psychology Anxiety/*epidemiology/psychology Child Comorbidity Depression/*epidemiology/psychology Female Follow-Up Studies Headache/*epidemiology/psychology Humans Male Mental Disorders/*epidemiology/psychology Norway/epidemiology Recurrence Young Adult LA - eng N1 - 1129-2377 Blaauw, Brit A Dyb, Grete Hagen, Knut Holmen, Turid L Linde, Mattias Wentzel-Larsen, Tore Zwart, John-Anker Journal Article J Headache Pain. 2015 Jan 16;16:10. doi: 10.1186/1129-2377-16-10. PY - 2015 SN - 1129-2369 (Print) 1129-2369 SP - 10 ST - The relationship of anxiety, depression and behavioral problems with recurrent headache in late adolescence – a Young-HUNT follow-up study T2 - J Headache Pain TI - The relationship of anxiety, depression and behavioral problems with recurrent headache in late adolescence – a Young-HUNT follow-up study VL - 16 ID - 3254 ER - TY - JOUR AB - Purpose of review Endometriosis can exist in the adolescent female. It can be a very disruptive disease and cause significant dysfunction at a time in life when self-esteem, school attendance, and school performance are critical to achievement of life goals. Approaches to diagnosis and management in the recent literature are reviewed, focusing on those that apply directly to the adolescent or indirectly, by extrapolation from work done in the adult population. Practical strategies for adolescent patient care are presented. Recent findings Recent research has focused on the efficacy of current treatment modalities and management of potential adverse side effects. Possible etiologies of endometriosis have been proposed, and therapies directed at those causes are being explored. Methods of diagnosis, both invasive and noninvasive, have been studied in order to determine the most effective way of diagnosing the disease. Summary A better understanding of the etiology of endometriosis would probably assist in determining the most suitable treatment strategies. Future work in adolescent endometriosis should focus on developing safe, minimally invasive, yet definitive options for diagnosis and treatment. AN - WOS:000178349600005 AU - Black, A. Y. AU - Jamieson, M. A. DA - Oct DO - 10.1097/00001703-200210000-00005 IS - 5 N1 - Black, AY Jamieson, MA 1473-656x PY - 2002 SN - 1040-872X SP - 467-474 ST - Adolescent endometriosis T2 - Current Opinion in Obstetrics & Gynecology TI - Adolescent endometriosis UR - ://WOS:000178349600005 VL - 14 ID - 2821 ER - TY - JOUR AB - INTRODUCTION: Emergency department (ED) overcrowding has been a significant problem for the last 10 years. Several studies have shown that a relatively small number of ED patients are responsible for a disproportionate amount of ED visits. This study aims to describe the frequent users of our emergency department. METHODS: This was an institutional review board-approved descriptive study performed by a retrospective review of electronic records. This pilot describes and compares patients who had 12 or more ED visits during the study year with those who visited less. RESULTS: The 234 patients who met criteria for high-frequency use (HFU) of the emergency department were responsible for a total of 4633 visits. Sex, race, and age distribution of HFU patients were similar to those of general ED patients. Eighty-four percent of HF users have insurance and 93% have primary care providers. A relatively small percentage of HFU visits, 4%, were mental health-related visits and 3% were alcohol- and drug-related visits. The HFU visits are socially connected: 93% have their own homes; 94% have relatives or friends; 73% have a religious affiliation. Pain or pain-related conditions are the most common diagnoses. These patients are also frequent users of ambulatory care services. CONCLUSION: The similarities between our HFU and the general ED population are more numerous than their differences. The HFU patients of our emergency department are different in terms of age, employment status, and type of insurance. IMPLICATIONS FOR NURSES: A detailed description of local HFU may help to inform planning and better meet ED patients' needs. As one of many results of this study, the ED chairman met with the Hematology-Oncology team and reviewed the protocol for ED management of sickle cell crisis. The meeting resulted in a revised protocol, including an immediate change in their pain medication from meperidine to either morphine or hydromorphone. AD - Department of Emergency Medicine, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199, USA. Del.Blank@bhs.org AN - 15834378 AU - Blank, F. S. AU - Li, H. AU - Henneman, P. L. AU - Smithline, H. A. AU - Santoro, J. S. AU - Provost, D. AU - Maynard, A. M. DA - Apr DO - 10.1016/j.jen.2005.02.008 DP - NLM ET - 2005/04/19 IS - 2 KW - Academic Medical Centers/*statistics & numerical data Adolescent Adult Age Distribution Aged Anemia, Sickle Cell/epidemiology/therapy Continental Population Groups/statistics & numerical data Diagnosis-Related Groups/statistics & numerical data Emergency Nursing/organization & administration Emergency Service, Hospital/*statistics & numerical data Employment/statistics & numerical data Female Health Care Surveys Health Services Accessibility/organization & administration Health Services Misuse/*statistics & numerical data Health Services Needs and Demand Humans Insurance, Health/statistics & numerical data Male Massachusetts/epidemiology Middle Aged Pain/epidemiology Pain Management Patient Acceptance of Health Care/*statistics & numerical data Pilot Projects Retrospective Studies Sex Distribution Social Support LA - eng N1 - Blank, Fidela S J Li, Haiping Henneman, Philip L Smithline, Howard A Santoro, John S Provost, Deborah Maynard, Ann M Journal Article United States J Emerg Nurs. 2005 Apr;31(2):139-44. doi: 10.1016/j.jen.2005.02.008. PY - 2005 SN - 0099-1767 (Print) 0099-1767 SP - 139-44 ST - A descriptive study of heavy emergency department users at an academic emergency department reveals heavy ED users have better access to care than average users T2 - J Emerg Nurs TI - A descriptive study of heavy emergency department users at an academic emergency department reveals heavy ED users have better access to care than average users VL - 31 ID - 3895 ER - TY - JOUR AB - The Quantitative Sensory Testing (QST) protocol of the German research network on neuropathic pain (DFNS) encompassing all somatosensory modalities assesses the functioning of different nerve fibers and of central pathways. The aim of our study was: (1) to explore, whether this QST protocol is feasible for children, (2) to detect distribution properties of QST data and the impact of body site, age and gender and (3) to establish reference values for QST in children and adolescents. The QST protocol of the DFNS with modification of instructions and pain rating was used in 176 children aged 6.12-16.12 years for six body sites. QST was feasible for children over 5 years of age. ANOVAs revealed developmental, gender and body site differences of somatosensory functions similar to adults. The face was more sensitive than the hand and/or foot. Younger children (6-8 years) were generally less sensitive to all thermal and mechanical detection stimuli but more sensitive to all pain stimuli than older (9-12 years) children, whereas there were little differences between older children and adolescents (13-17 years). Girls were more sensitive to thermal detection and pain stimuli, but not to mechanical detection and pain stimuli. Reference values differ from adults, but distribution properties (range, variance, and side differences) were similar and plausible for statistical factors. Our results demonstrate that the full QST protocol is feasible and valid for children over 5 years of age with their own reference values. (C) 2010 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved. AN - WOS:000275789500014 AU - Blankenburg, M. AU - Boekens, H. AU - Hechler, T. AU - Maier, C. AU - Krumova, E. AU - Scherens, A. AU - Magerl, W. AU - Aksu, F. AU - Zernikow, B. DA - Apr DO - 10.1016/j.pain.2010.01.011 IS - 1 N1 - Blankenburg, M. Boekens, H. Hechler, T. Maier, C. Krumova, E. Scherens, A. Magerl, W. Aksu, F. Zernikow, B. Enax-Krumova, Elena/J-5638-2019 Enax-Krumova, Elena/0000-0002-6162-9414 1872-6623 PY - 2010 SN - 0304-3959 SP - 76-88 ST - Reference values for quantitative sensory testing in children and adolescents: Developmental and gender differences of somatosensory perception T2 - Pain TI - Reference values for quantitative sensory testing in children and adolescents: Developmental and gender differences of somatosensory perception UR - ://WOS:000275789500014 VL - 149 ID - 2560 ER - TY - JOUR AB - Primary headache disorders such as migraine and tension-type headache begin as early as childhood or adolescence. Prevalence increases during primary school and adolescence. In tension-type headache, central pain sensitization and activation of central nociceptive neurons plays an important role. Migraine is a primary brain disorder with abnormalities in pain modulating systems and cortical stimulus processing. Bio-psycho-social factors play a decisive role in both types of headache. Secondary headaches due to an inflammatory or a structural brain alteration are rare. Diagnosis is based on clinical criteria. Typical recurrent headaches are diagnosed by patient's history and physical examination. In case of abnormalities, further diagnostic is needed. Treatment of tension-type headache is focused on multimodal pain therapy, treatment of migraine is focused on medication of attacks and secondary headaches need treatment of the underlying disease. Treatment goals are the reduction of pain perception, promotion of control and self-efficacy experiences, the increase of physical performance as well as the resumption of normal everyday structures and social contacts as a prerequisite for an increasing pain reduction. AN - WOS:000455222400002 AU - Blankenburg, M. AU - Schroth, M. AU - Braun, S. DA - Jan DO - 10.1055/a-0710-5014 IS - 1 N1 - Blankenburg, Markus Schroth, Michael Braun, Sarah 1439-3824 PY - 2019 SN - 0300-8630 SP - 14-20 ST - Chronic Headache in Children and Adolescents T2 - Klinische Padiatrie TI - Chronic Headache in Children and Adolescents UR - ://WOS:000455222400002 VL - 231 ID - 1971 ER - TY - JOUR AB - The authors examined associations among parental and child adjustment, child syncope, somatic, and school problems. Participants were children (N = 56) ages 7-18 years with syncope. Measures included syncope severity, parental distress, and children's internalizing symptoms. For children diagnosed negative for neurocardiogenic syncope (NCS), their fathers' and their own psychological symptoms were positively associated with the severity of syncope, whereas their mothers' functioning was negatively associated with the severity of syncope. Also, for the negative NCS group, fathers' psychological functioning was associated with children's nonsyncope somatic complaints but not with their school problems. For the positive NCS group, few significant father-child associations were found, but several significant positive associations were revealed between mothers' psychological symptoms and their children's syncope as well as somatic and school problems. AN - WOS:000222924600006 AU - Blount, R. L. AU - Morris, J. A. B. AU - Cheng, P. S. AU - Campbell, R. M. AU - Brown, R. T. DA - Aug DO - 10.1037/0022-006x.72.4.597 IS - 4 N1 - Blount, RL Morris, JAB Cheng, PS Campbell, RM Brown, RT Brown, Ronald/0000-0002-9656-4614 PY - 2004 SN - 0022-006X SP - 597-604 ST - Parent and child psychological factors in pediatric syncope and other somatic symptoms T2 - Journal of Consulting and Clinical Psychology TI - Parent and child psychological factors in pediatric syncope and other somatic symptoms UR - ://WOS:000222924600006 VL - 72 ID - 2787 ER - TY - JOUR AB - OBJECTIVE: To study the prevalence of complaints of recurrent abdominal pain (RAP) among school children aged 11-12 years in a rural setting in Malaysia. METHODOLOGY: Questionnaires were distributed to all parents and teachers of children aged 11-12 years who attended a small rural school in which all the children were Malays. Complaints of RAP were defined as at least three such complaints occurring over a period of at least 3 months. RESULTS: One hundred and sixty questionnaires were distributed, of which 148 were returned, giving a response rate of 92.5%. Sixty-one children (41.2%) had RAP. Approximately 45.2% of girls and 35.9% of boys reported having RAP. Compared with children without RAP, there was a significantly larger number of children with RAP (85.2%) who had at least one stress factor (P = 0.0109). There were no significant associations between RAP and total family income (P = 0.0573), a history of abdominal pain in at least one parent (P = 0.1686), a history of abdominal pain in at least one sibling (P = 0.0617), academic performance (P = 0.9967) or the degree of sports participation (P = 0.8469). There was an increased incidence of other systemic complaints in children with RAP when compared with children without RAP. CONCLUSION: Recurrent abdominal pain was found to be common among 11- to 12-year-old children in a rural Malay school. There was a significant association found between RAP and the presence of stressful events, as well as with the presence of other systemic complaints. AD - Department of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. boeycm@medicine.med.um.edu.my AN - 10404456 AU - Boey, C. C. AU - Yap, S. B. DA - Jun DO - 10.1046/j.1440-1754.1999.00366.x DP - NLM ET - 1999/07/15 IS - 3 KW - Abdominal Pain/*epidemiology/psychology Child Chronic Disease Female Humans Malaysia/epidemiology Male Prevalence Risk Factors Rural Population Socioeconomic Factors Stress, Psychological/complications LA - eng N1 - Boey, C C Yap, S B Journal Article Australia J Paediatr Child Health. 1999 Jun;35(3):303-5. doi: 10.1046/j.1440-1754.1999.00366.x. PY - 1999 SN - 1034-4810 (Print) 1034-4810 SP - 303-5 ST - An epidemiological survey of recurrent abdominal pain in a rural Malay school T2 - J Paediatr Child Health TI - An epidemiological survey of recurrent abdominal pain in a rural Malay school VL - 35 ID - 3562 ER - TY - JOUR AB - Aim. To look at predictors of consulting behaviour among children with recurrent abdominal pain in a rural community in Malaysia. Subjects and methods. A sample of 1462 school-children aged between 9 and 15 years were randomly selected from all schools in Kuala Langat, a rural district in Malaysia. Those with recurrent abdominal pain, defined according to Apley's criteria, were recruited and divided into consulters and non-consulters. A consulter was defined as a child who had sought the help of a medical practitioner at least once in the past year for recurrent abdominal pain. A detailed clinical, social and family history was obtained in all recruited children. Results. A total of 161 children were recruited: 78 (48.4%) consulters, 83 (51.6%) non-consulters. Of the consulters, 40 were boys, 38 were girls (male:female ratio = 1.1:1). The two sexes did not show a significant difference in prevalence of consulters (p=0.189). Of the ethnic groups, only Indians had a significantly higher likelihood to consult a doctor (Indians, p=0.006; Malays, p=0.742; Chinese, p=0.050). Younger children (under 12 years) had a significantly higher chance of having been brought to see a medical practitioner (p=0.014). Children in whom age of onset of abdominal pain was below ten years were also more likely to have been seen by a doctor (p=0.012). Children who had consulted a doctor were more likely to be missing school because of abdominal pain (p<0.001). Pain severity was not a significant factor (p=0.429). Multiple logistic regression analysis revealed that the only variable that remained significantly associated with health-care consultation was school absence (p=0.001). Conclusions. Children who saw their doctors for recurrent abdominal pain were also more likely to be those who missed school on account of abdominal pain. Following multiple regression analysis, other factors were no longer significant. AN - WOS:000168199500008 AU - Boey, C. C. M. AU - Goh, K. L. DA - Mar DO - 10.1016/s1590-8658(01)80069-4 IS - 2 N1 - Boey, CCM Goh, KL Boey, Christopher/D-4472-2012; Goh, Khean-Lee/B-6404-2009 PY - 2001 SN - 1125-8055 SP - 140-144 ST - Recurrent abdominal pain and consulting behaviour among children in a rural community in Malaysia T2 - Digestive and Liver Disease TI - Recurrent abdominal pain and consulting behaviour among children in a rural community in Malaysia UR - ://WOS:000168199500008 VL - 33 ID - 2854 ER - TY - JOUR AB - Aim: To look at the predictors of health-care consultation for recurrent abdominal pain among urban schoolchildren in Malaysia. Methods: Recurrent abdominal pain was defined as 'at least three episodes of abdominal pain, severe enough to affect a child's activities over a period longer than 3 months. A health-care consulter was defined as a child who had been brought to see a doctor regarding recurrent abdominal pain at least once in the past year. Children aged between 9 and 15 years were randomly chosen from schools in the city of Petaling Jaya, given questionnaires to fill in and interviewed to determine whether they fulfilled the above criteria for having symptoms of recurrent abdominal pain and for being a consulter. Bivariate analysis and multiple logistic regression analysis were performed on the data obtained. Results: One hundred and forty-three (9.61%) children fulfilled the criteria for recurrent abdominal pain out of a total of 1488 schoolchildren interviewed. There were 65 (45.5%) consulters and 78 (54.5%) non-consulters. Among the consulters, the male to female ratio was 1:1.4, while among the non-consulters, the ratio was 1:1.1. On bivariate analysis, the Chinese had a significantly lower likelihood to consult a doctor (P = 0.02), while the other two races did not show any increase in consultation (Malays, P = 0.08; Indians, P = 0.21). Among those with severe pain, there was a significantly higher prevalence of consulters (P < 0.01). Furthermore, those whose sleep was interrupted by abdominal pain were more likely to consult (P < 0.01). Children who had consulted a doctor were more likely to be missing school because of abdominal pain (P < 0.01). Following multiple logistic regression analysis, ethnicity was no longer a significant predictor. Conclusions: Approximately 45.5% of schoolchildren with recurrent abdominal pain in an urban setting were brought to see a doctor. Predictors of recent health-care consultation were school absence, pain severity and interruption of sleep caused by abdominal pain. (C) 2001 Blackwell Science Asia Pty Ltd. AN - WOS:000167702900007 AU - Boey, C. C. M. AU - Goh, K. L. DA - Feb DO - 10.1046/j.1440-1746.2001.02434.x IS - 2 N1 - Boey, CCM Goh, KL Boey, Christopher/D-4472-2012; Goh, Khean-Lee/B-6404-2009 PY - 2001 SN - 0815-9319 SP - 154-159 ST - Predictors of health-care consultation for recurrent abdominal pain among urban schoolchildren in Malaysia T2 - Journal of Gastroenterology and Hepatology TI - Predictors of health-care consultation for recurrent abdominal pain among urban schoolchildren in Malaysia UR - ://WOS:000167702900007 VL - 16 ID - 2856 ER - TY - JOUR AB - Objective: This systematic review explored the potential impact of parental multiple sclerosis on their offspring. It considered adjustment to parental multiple sclerosis at different developmental stages and the factors associated with good versus poor adjustment. Data sources: MEDLINE, EMBASE, PsycINFO, CINAHL and Web of Science were searched for studies on children with a parent with multiple sclerosis. Inclusion and exclusion criteria were formulated. Hand-searching journals and reference lists, contacting authors and multiple sclerosis societies for additional unpublished papers complemented the searches. Review methods: Twenty studies that satisfied the inclusion criteria were included. The research articles were ranked according to a quality assessment checklist and were categorized as good, medium or poor quality. Results: The review found good evidence to suggest that parental multiple sclerosis has a negative impact on children's social and family relationships and their psychological well-being. The review also identified potential factors associated with poor adjustment. These factors included parental negative emotions, increased illness severity, family dysfunction, children's lack of knowledge about the illness and lack of social support. Adolescent children also seemed to be more at risk for psychosocial problems than school-age children. Conclusions: There is good evidence that parental multiple sclerosis has a negative psychosocial impact on children, especially on adolescents. AN - WOS:000281352500002 AU - Bogosian, A. AU - Moss-Morris, R. AU - Hadwin, J. DA - Sep DO - 10.1177/0269215510367982 IS - 9 N1 - Bogosian, Angeliki Moss-Morris, Rona Hadwin, Julie Bogosian, Angeliki/0000-0003-1244-6387; Moss-Morris, Rona/0000-0002-2927-3446 1477-0873 PY - 2010 SN - 0269-2155 SP - 789-801 ST - Psychosocial adjustment in children and adolescents with a parent with multiple sclerosis: a systematic review T2 - Clinical Rehabilitation TI - Psychosocial adjustment in children and adolescents with a parent with multiple sclerosis: a systematic review UR - ://WOS:000281352500002 VL - 24 ID - 2537 ER - TY - JOUR AB - OBJECTIVE: To explore and describe older African Americans' patterns and perceptions of managing chronic osteoarthritis pain. METHODS: A convergent parallel mixed-methods design incorporating cross-sectional surveys and individual, semistructured interviews. SETTING: One hundred ten African Americans (≥50 years of age) with clinical osteoarthritis (OA) or provider-diagnosed OA from communities in northern Louisiana were enrolled. RESULTS: Although frequency varied depending on the severity of pain, older African Americans actively used an average of seven to eight self-management strategies over the course of a month to control pain. The average number of self-management strategies between high and low education and literacy groups was not statistically different, but higher-educated adults used approximately one additional strategy than those with high school or less. To achieve pain relief, African Americans relied on 10 self-management strategies that were inexpensive, easy to use and access, and generally perceived as helpful: over-the-counter (OTC) topicals, thermal modalities, land-based exercise, spiritual activities, OTC and prescribed analgesics, orthotic and assistive devices, joint injections, rest, and massage and vitamins. CONCLUSIONS: This is one of the first studies to quantitatively and qualitatively investigate the self-management of chronic OA pain in an older African American population that happened to be a predominantly higher-educated and health-literate sample. Findings indicate that Southern-dwelling African Americans are highly engaged in a range of different self-management strategies, many of which are self-initiated. Although still an important component of chronic pain self-management, spirituality was used by less than half of African Americans, but use of oral nonsteroidal anti-inflammatory drugs and opioids was relatively high. AD - Pain Research and Intervention Center of Excellence, The University of Florida, Gainesville, Florida. College of Nursing, The University of Iowa, Iowa City, Iowa, USA. AN - 30541043 AU - Booker, S. AU - Herr, K. AU - Tripp-Reimer, T. C2 - PMC7963201 DA - Aug 1 DO - 10.1093/pm/pny260 DP - NLM ET - 2018/12/13 IS - 8 KW - Administration, Topical Adrenal Cortex Hormones/therapeutic use *African Americans Aged Aged, 80 and over Analgesics/therapeutic use Analgesics, Opioid/therapeutic use Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Arthralgia/*therapy *Attitude to Health Chronic Pain/*therapy Cross-Sectional Studies Educational Status Exercise Female Health Literacy Hot Temperature/therapeutic use Humans Hyaluronic Acid/therapeutic use Injections, Intra-Articular Louisiana Male Massage Middle Aged Nonprescription Drugs Orthotic Devices Osteoarthritis/*therapy Pain Management Qualitative Research Religion Rest Self-Help Devices Self-Management/*methods Spirituality Surveys and Questionnaires Viscosupplements/therapeutic use *African American *Aging *Blacks *Joint *Osteoarthritis *Pain *Self-Management LA - eng N1 - 1526-4637 Booker, Staja Herr, Keela Tripp-Reimer, Toni T32 NR011147/NR/NINR NIH HHS/United States T32 AG049673/AG/NIA NIH HHS/United States Journal Article Pain Med. 2019 Aug 1;20(8):1489-1499. doi: 10.1093/pm/pny260. PY - 2019 SN - 1526-2375 (Print) 1526-2375 SP - 1489-1499 ST - Patterns and Perceptions of Self-Management for Osteoarthritis Pain in African American Older Adults T2 - Pain Med TI - Patterns and Perceptions of Self-Management for Osteoarthritis Pain in African American Older Adults VL - 20 ID - 3598 ER - TY - JOUR AB - Objective: Minimally invasive repair of pectus excavatum (MIRPE) have gained support recently as it can be applied in both children and adults successfully. Our objective was to review minimally invasive repair of pectus excavatum in Marmara University School of Medicine. Patients and Methods: One hundred and sixty eight cases who had minimally invasive repair between August-2005 and November-2010 were reviewed retrospectively. Cases were evaluated according to demographics, surgical indication, form of deformity, concommitant anomalies, family history, previous corrections, number of bars, duration of the operation, concommitant procedures, pain management, peri-andpostoperative complications, bar removal, and patient satisfaction. Results: One hundred and forty one cases were male, 27 were female. Median age was 16. The deformity was symmetric in 110, asymmetric in 58 cases. The most common concommitant anomaly was scoliosis in 27 cases. 26 cases had a family history for deformity. 14 cases had a previous open repair. 1 bar in 105, 2 in 58, 3 in 5 cases were placed for correction. The median duration of the operation was 60 minutes. The most common perioperative complication was pneumothorax in 12 cases. The most common postoperative complication was wound infection in 8 cases. Bar removal was performed in 7 cases with only one recurrence. Quality-of-life questionnaires revealed that 94% of patients were satisfied with the treatment. Conclusion: This minimally invasive technique is a promising procedure for better cosmetic results and high levels of patient satisfaction. AN - WOS:000219993000007 AU - Bostanci, K. AU - Ozalper, H. AU - Yuksel, M. DO - 10.5472/mmj.2010.01752.1 IS - 1 N1 - Bostanci, Korkut Ozalper, Hakan Yuksel, Mustafa PY - 2011 SN - 1309-9469 SP - 38-43 ST - Minimally Invasive Repair Technique for Pectus Excavatum Deformity: The Marmara Experience T2 - Marmara Medical Journal TI - Minimally Invasive Repair Technique for Pectus Excavatum Deformity: The Marmara Experience UR - ://WOS:000219993000007 VL - 24 ID - 2522 ER - TY - JOUR AB - A 15-year-old competitive right-handed high school baseball pitcher experienced an acute onset of right elbow pain when throwing. He initially treated it conservatively with rest alone for 3 months, but on return to throwing, he was still experiencing pain. Radiographs revealed that he had a persistent olecranon physis. He proceeded with a trial of low-intensity pulsed ultrasound therapy and attained radiographic evidence of bony union at 7 months postinjury, thus avoiding surgical intervention. He returned to pitching competitively 9 months after injury without elbow pain. This is the first reported case of using ultrasound bone stimulation for treatment of a symptomatic persistent olecranon physis in a baseball pitcher. AD - Florida Spine Institute, Clearwater, Florida. University of Central Florida College of Medicine, Orlando, Florida. AN - 28654442 AU - Botwin, K. AU - McMillen, T. AU - Botwin, A. DA - Jul DO - 10.1097/jsm.0000000000000449 DP - NLM ET - 2017/06/28 IS - 4 KW - Adolescent Baseball/*injuries Elbow Joint/*injuries Epiphyses/pathology Growth Plate/pathology Humans Male Olecranon Process/*pathology *Pain Management *Ultrasonic Therapy Ultrasonic Waves LA - eng N1 - 1536-3724 Botwin, Kenneth McMillen, Thurston Botwin, Ariel Case Reports Journal Article United States Clin J Sport Med. 2018 Jul;28(4):e82-e84. doi: 10.1097/JSM.0000000000000449. PY - 2018 SN - 1050-642x SP - e82-e84 ST - Low-Intensity Pulsed Ultrasound Therapy for a Symptomatic Persistent Olecranon Physis in an Adolescent Baseball Pitcher T2 - Clin J Sport Med TI - Low-Intensity Pulsed Ultrasound Therapy for a Symptomatic Persistent Olecranon Physis in an Adolescent Baseball Pitcher VL - 28 ID - 3745 ER - TY - JOUR AB - Background Although increasing participation in physical activities has significant health benefits, there are no guidelines to help professionals decide when it is safe to return to activity after injury. Objective To examine the specific criteria (eg, strength, pain) that expert sport medicine clinicians use for return to activity decisions in children with musculoskeletal injuries. Methods The authors conducted an online cross-sectional survey of certified Canadian sport medicine doctors (MDs) and sport rehabilitation specialists (physiotherapists (PTs) or athletic therapists (ATs)). The authors asked how they would measure each of the following signs in the context of a knee injury: sport-specific skills, pain, swelling, strength, range of motion (ROM) and balance. Clinicians also ranked the importance of each sign with respect to influencing their recommendations for each of five clinical vignettes. Results The overall response rate was 33.6% (464/1380) with similar rates for each profession. For each clinical sign, all three professions preferred the same measure to determine readiness to return to play: standardised testing for sport-specific skills, impact on function for pain, palpation for swelling, manual muscle testing for strength, visual inspection for ROM and standing on one leg with eyes closed for balance. Regarding importance of specific signs for return to activity, all professions had similar responses for one vignette, but MDs differed from PTs and ATs for the remaining four. Finally, pain was ranked as the no 1 or 2 most important sign in all five vignettes by 41.0% of MDs, 18.1% of ATs and 11.3% of PTs, whereas sport-specific skills was chosen by 9.6% MDs, 12.0% ATs and 16.1% PTs. Conclusion Our results provide the foundation for future work leading towards the development of interdisciplinary consensus guidelines. AN - WOS:000296061300013 AU - Boudier-Reveret, M. AU - Mazer, B. AU - Feldman, D. E. AU - Shrier, I. DA - Nov DO - 10.1136/bjsm.2009.071233 IS - 14 N1 - Boudier-Reveret, Mathieu Mazer, Barbara Feldman, Debbie Ehrmann Shrier, Ian Boudier-Reveret, Mathieu/X-1525-2018; Shrier, Ian/AAI-6502-2020 Boudier-Reveret, Mathieu/0000-0003-0259-8520; Shrier, Ian/0000-0001-9914-3498 PY - 2011 SN - 0306-3674 SP - 1137-1143 ST - Practice management of musculoskeletal injuries in active children T2 - British Journal of Sports Medicine TI - Practice management of musculoskeletal injuries in active children UR - ://WOS:000296061300013 VL - 45 ID - 2472 ER - TY - JOUR AB - Parental encouragement of illness behavior is hypothesized to correlate with psychosocial dysfunction in adolescents with chronic illness. To explore this hypothesis, adolescents aged 11 to 17 years with chronic fatigue syndrome (CFS) (n = 10), juvenile rheumatoid arthritis (JRA) (n = 16), and healthy adolescents (n = 14) were recruited for the study. Measures included the Achenbach parent and youth self report forms, the Family Adaptability and Cohesion Evaluation Scale-ii (FACES II), the Children's Depression Rating Scale, and number of days absent from school. The Illness Behavior Encouragement Scale (IBES) generated measures of parental reinforcement of illness behavior. As predicted, the teens with CFS scored statistically higher on measures of depression, total competence, and number of days of school missed in the previous 6 months (mean = 40). Children with JRA scored significantly lower than the CFS group on the measure of parental reinforcement of illness behavior. The healthy group produced intermediate scores. Results and implications for future clinical and research activity are discussed. AN - WOS:000089857900003 AU - Brace, M. J. AU - Smith, M. S. AU - McCauley, E. AU - Sherry, D. D. DA - Oct DO - 10.1097/00004703-200010000-00003 IS - 5 N1 - Brace, MJ Smith, MS McCauley, E Sherry, DD PY - 2000 SN - 0196-206X SP - 332-339 ST - Family reinforcement of illness behavior: A comparison of adolescents with chronic fatigue syndrome, juvenile arthritis, and healthy controls T2 - Journal of Developmental and Behavioral Pediatrics TI - Family reinforcement of illness behavior: A comparison of adolescents with chronic fatigue syndrome, juvenile arthritis, and healthy controls UR - ://WOS:000089857900003 VL - 21 ID - 2863 ER - TY - JOUR AB - This study aimed to describe the outcomes of children with sickle cell disease (SCD) after discharge from medical care for vaso-occlusive painful events and to test the hypothesis that older age, longer length of hospital stay, and a history of frequent vaso-occlusive painful events will be associated with poor outcomes. Children aged 2-18 years with SCD treated in the emergency department or inpatient unit for a painful event were contacted after discharge to assess: days of pain, days of functional limitations for the child, and days of work/school absenteeism for the caregiver. Descriptive statistics were applied and multivariate logistic regression examined the association between the predictors and outcomes. Fifty-eight children were enrolled (mean age 10.8 +/- 4.8 years, 53.5% female). Postdischarge, 46.5% of children reported three or more days of pain, 54.3% had two or more days of functional limitations, and 24.3% of caregivers missed two or more days of work/school. Children with three or more prior painful events had increased odds of a poor outcome postdischarge (OR 1.79; 95% CI = 1.026, 3.096). In conclusion, acute vaso-occlusive painful events impact the lives of children with SCD and their caregivers, even after discharge to home. AN - WOS:000262826400018 AU - Brandow, A. M. AU - Brousseau, D. C. AU - Panepinto, J. A. DA - Mar DO - 10.1111/j.1365-2141.2008.07512.x IS - 5 N1 - Brandow, Amanda M. Brousseau, David C. Panepinto, Julie A. 1365-2141 PY - 2009 SN - 0007-1048 SP - 782-788 ST - Postdischarge pain, functional limitations and impact on caregivers of children with sickle cell disease treated for painful events T2 - British Journal of Haematology TI - Postdischarge pain, functional limitations and impact on caregivers of children with sickle cell disease treated for painful events UR - ://WOS:000262826400018 VL - 144 ID - 2607 ER - TY - JOUR AB - Musculoskeletal pain is exceedingly common in young adults. With the aim of studying these symptoms in schoolchildren, a questionnaire survey was carried out among children 8, 11, 13 and 17 years old. The prevalence of back pain and headaches in 1,245 schoolchildren was studied, Twenty-nine per cent of the students reported back pain and 48% headache. In all age groups studied, both back pain and headaches were more common among girls than boys. Girls also reported more frequent symptoms than boys. In a longitudinal study 471 schoolchildren were asked a second time 2 years later. Nine per cent reported back pain and 30% headache in both surveys, Five per cent reported both back pain and headache on both occasions, Despite the reported symptoms most of the pupils did not report health problems. However, pupils with reported pain on both occasions may constitute a risk group for future chronic pain. There were statistically significant relationships between social, psychological and emotional factors and reported symptoms. No relationship between physical factors and reported symptoms were noted. The observed relationships are not proof of causal relations but did indicate areas of problems which make interventions targeting pupils at risk an appropriate measure. AN - WOS:A1994QB74500005 AU - Brattberg, G. DA - Dec DO - 10.1007/bf00433372 N1 - Brattberg, g Satellite Symposium of the 7th World Congress on Pain Aug 17-19, 1993 Lund univ hosp, lund, sweden 1 PY - 1994 SN - 0962-9343 SP - S27-S31 ST - THE INCIDENCE OF BACK PAIN AND HEADACHE AMONG SWEDISH SCHOOL-CHILDREN T2 - Quality of Life Research TI - THE INCIDENCE OF BACK PAIN AND HEADACHE AMONG SWEDISH SCHOOL-CHILDREN UR - ://WOS:A1994QB74500005 VL - 3 ID - 2944 ER - TY - JOUR AB - DESIGN: In a longitudinal study, 335 children ages 8, 11 and 14, first studied in 1989 were followed-up on two occasions in 1991 and 2002. The subjects filled in questionnaires on pain, the first two times in school, the last as a postal survey. PURPOSES: To determine if headache and back pain during the school years were transitory or if they grew into pain problems in adulthood; to determine predictors of pain. RESULTS: In the 2002 study, 59% of the women and 39% of the men reported pain at 21, 24 and 27 years. A total of 68 (52 women, 16 men) or 20% of the subjects reported pain symptoms in all three studies. The cumulative incidence rate for the presence of pain in the cohort studied was 31% for 1989-2002 and 43% for 1991-2002. Four of the 10 individuals with pain also reported signs of stress. Three predictors were found: reported back pain in 8-14-year-olds (p < 0.0001); reported headaches once a week or more in the same age group (p < 0.0001); and a positive response in the ages 10-16 to the question: "Do you often feel nervous?" (OR=2.1, 95% CI 1.3-3.4). When adjusted for age, sex and all psychosocial risk determinants studied in multiple logistic regression, a positive answer to this question was a significant predictor of pain in young adulthood. A positive response by the 10-16-year-olds to "Do you find it difficult to describe your feelings?" was a predictor of pathological anxiety in early adulthood, but stress perceived in childhood/adolescence did not predict future pain or stress. CONCLUSIONS: Since pain reports in childhood and early adolescence seem to be associated with the report of pain in early adulthood, more attention should be given to the way ill-health is managed in adolescence in this vulnerable group. AU - Brattberg, Gunilla DA - 2004/06// DO - 10.1016/j.ejpain.2003.08.001 DP - PubMed IS - 3 J2 - Eur J Pain KW - Adolescent Adult Age Factors Causality Child Chronic Disease Comorbidity Female Follow-Up Studies Headache Health Status Humans Incidence Longitudinal Studies Male Pain Pain Measurement Predictive Value of Tests Quality of Life Sex Factors Stress, Psychological Surveys and Questionnaires Sweden LA - eng PY - 2004 SN - 1090-3801 SP - 187-199 ST - Do pain problems in young school children persist into early adulthood? T2 - European Journal of Pain (London, England) TI - Do pain problems in young school children persist into early adulthood? A 13-year follow-up UR - http://www.ncbi.nlm.nih.gov/pubmed/15109969 VL - 8 ID - 127 ER - TY - JOUR AB - We estimated the prevalence of chronic diseases and other health problems reported by adolescents in relation to social and demographic variables and nutritional status. This cross-sectional population-based survey analyzed data from the Health Survey in Campinas, São Paulo State, Brazil, 2008. We used descriptive statistics and associations between variables with the chisquare test. Prevalence of chronic diseases among adolescents was 19.17%, with asthma showing the highest prevalence (7.59%), followed by heart disease (1.96%), hypertension (1.07%), and diabetes 0.21%. Prevalence rates were 61.53% for health problems, 40.39% for allergy, and 24.83% for frequent headache or migraine. After multivariate analysis using Poisson regression, the factors associated with chronic disease were age 15 to 19 years (PR = 1.38), not attending school (PR = 1.46), having children (PR = 1.84), and obesity (PR = 1.54). Female gender (PR = 1.12) was statistically associated with health problems. The study illustrates that adolescence is a life stage in which chronic disease and health problems can occur. AD - Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brasil. AN - 24068232 AU - Braz, M. AU - Barros Filho, A. A. AU - Barros, M. B. DA - Sep DO - 10.1590/0102-311x00169712 DP - NLM ET - 2013/09/27 IS - 9 KW - Adolescent Asthma/epidemiology Brazil/epidemiology Cardiovascular Diseases/epidemiology Child Chronic Disease/classification/*epidemiology Epidemiologic Methods Female Headache/epidemiology Humans Male Migraine Disorders/epidemiology Pregnancy Socioeconomic Factors Urban Population Young Adult LA - por N1 - 1678-4464 Braz, Marici Barros Filho, Antonio A Barros, Marilisa B A English Abstract Journal Article Research Support, Non-U.S. Gov't Brazil Cad Saude Publica. 2013 Sep;29(9):1877-88. doi: 10.1590/0102-311x00169712. OP - Saúde dos adolescentes: um estudo de base populacional em Campinas, São Paulo, Brasil. PY - 2013 SN - 0102-311x SP - 1877-88 ST - [Adolescent health: a population-based study in Campinas, São Paulo State, Brazil] T2 - Cad Saude Publica TI - [Adolescent health: a population-based study in Campinas, São Paulo State, Brazil] VL - 29 ID - 3385 ER - TY - JOUR AB - Background: Children with severe cognitive impairments are believed to suffer pain frequently. Objective: To document the frequency, duration, and intensity of pain experienced by children with severe cognitive impairments. Design: Cohort study using surveys during 1 year. Setting: Tertiary-care pediatric center for 3 provinces in eastern Canada. Participants: Caregivers of 94 children and adolescents with moderate to profound mental retardation, aged 3 to 18 years (mean age, 10.1 years [SD, 4.3 years]). Forty-four children had cerebral palsy and 59 had a seizure disorder; 83 lived with family, and 11 in group homes. Results: A total of 406 episodes of pain occurred. During a 4-week period, 73 children (78%) experienced pain at least once, and 58 (62%) had nonaccidental pain. Accidental pain was most frequent (n=28 [30%]), followed by gastrointestinal tract (n=21 [22%]), infection (n=19 [20%]), and musculoskeletal (n=18 [19%]) pain. Each week, 33 to 49 children (35%-52%) had pain. Mean pain duration was longer than 9 hours per week (SD, 1.7-2.4 hours). Mean intensity was 6.1 (SD, 2.2) for nonaccidental pain and 3.8 (SD, 2.1) for accidental pain. Children with the fewest abilities had more nonaccidental pain (F(4,89)= 3.7; P=.007), and children with greater motor abilities had more accidental pain (F(4,89)= 2.8; P=.03). Pain did not vary with demographic characteristics. Conclusions: Children with severe cognitive impairments experience pain frequently, mostly not due to accidental injury. Children with the fewest abilities experience the most pain. AN - WOS:000186959800017 AU - Breau, L. M. AU - Camfield, C. S. AU - McGrath, P. J. AU - Finley, G. A. DA - Dec DO - 10.1001/archpedi.157.12.1219 IS - 12 N1 - Breau, LM Camfield, CS McGrath, PJ Finley, GA Meeting of the Canadian-Pain-Society May 22, 2003 Toronto, canada Canadian Pain Soc McGrath, Patrick J/F-4326-2011; Finley, Allen/AAD-7583-2020 Finley, Allen/0000-0003-4579-7749; McGrath, Patrick/0000-0002-9568-2571 PY - 2003 SN - 1072-4710 SP - 1219-1226 ST - The incidence of pain in children with severe cognitive impairments T2 - Archives of Pediatrics & Adolescent Medicine TI - The incidence of pain in children with severe cognitive impairments UR - ://WOS:000186959800017 VL - 157 ID - 2800 ER - TY - JOUR AB - OBJECTIVES: Non-specific chronic low back pain (NSCLBP): Which conservative therapy shows an evident effectiveness - A review of the current literature. MATERIALS AND METHODS: Our results are based on literature reviews of current randomised control studies, reviews and meta-analysis drawn from the Cochrane Library and Medline-Database between the years 2004 until 2015. German and English Studies were included. We focused on different conservative Treatments of NSCLBP, which are listed at, the NVL-Guidelines. Based on the given evidence we evaluated their effectiveness. RESULTS: As part of the review we identified 4657 Publications, 85 were included in this study. Therapeutic options such as bed rest, TENS, Massage, Spine Supports, Back Schools and Antidepressants showed no evident effectiveness. Injections, NSAR analgesic therapy, Thermotherapy and Opioid analgesic therapy indicated a short-time effectiveness. A long term success (> 6 weeks) however, can not be shown. Only the Movement therapy can, in the summation of the included studies, postulate an evident (Evidence Level I) long-term effect treating NSCLBP. Only a few therapy options indicate a significant evident effectiveness for treating NSCLBP conservatively. At short notice methods such as injection therapy, thermo-therapy and analgesic therapies with NSAR and/or opioids help coping the acute phase. In the long term only movement therapy seems to provide an evident effectiveness. In the case of therapy-refractory NSCLBP a multimodal therapy should be considered. AD - Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Köln, Joseph-Stelzmann-Str.24, 50931, Köln, Deutschland. jan.bredow@uk-koeln.de. Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Köln, Joseph-Stelzmann-Str.24, 50931, Köln, Deutschland. AN - 27075679 AU - Bredow, J. AU - Bloess, K. AU - Oppermann, J. AU - Boese, C. K. AU - Löhrer, L. AU - Eysel, P. DA - Jul DO - 10.1007/s00132-016-3248-7 DP - NLM ET - 2016/04/15 IS - 7 KW - Adolescent Adult Age Distribution Aged Aged, 80 and over Analgesics/*therapeutic use Chronic Pain/diagnosis/*epidemiology/*therapy Combined Modality Therapy/statistics & numerical data Evidence-Based Medicine Female Humans Hyperthermia, Induced/statistics & numerical data Low Back Pain/diagnosis/*epidemiology/*therapy Male Massage/statistics & numerical data Middle Aged Musculoskeletal Manipulations/*statistics & numerical data Pain Measurement/statistics & numerical data Prevalence Risk Factors Sex Distribution Transcutaneous Electric Nerve Stimulation/*statistics & numerical data Treatment Outcome Young Adult Analgesia Conservative therapy Low back pain Movement therapy Pain, chronic LA - ger N1 - 1433-0431 Bredow, J Bloess, K Oppermann, J Boese, C K Löhrer, L Eysel, P Journal Article Meta-Analysis Review Systematic Review Germany Orthopade. 2016 Jul;45(7):573-8. doi: 10.1007/s00132-016-3248-7. OP - Konservative Therapie beim unspezifischen, chronischen Kreuzschmerz : Evidenz der Wirksamkeit - eine systematische Literaturanalyse. PY - 2016 SN - 0085-4530 SP - 573-8 ST - [Conservative treatment of nonspecific, chronic low back pain : Evidence of the efficacy - a systematic literature review] T2 - Orthopade TI - [Conservative treatment of nonspecific, chronic low back pain : Evidence of the efficacy - a systematic literature review] VL - 45 ID - 2964 ER - TY - JOUR AB - OBJECTIVE: Functional abdominal pain is a common symptom in children and adolescents. Three years ago, we investigated the experiences among parents whose children had chronic abdominal pain but no somatic diagnosis. The aim of the present follow-up study was to explore those families' current situations. DESIGN: Interviews with open questions about the families' current pain situations were carried out by the first author. Interviews were audio-recorded and transcribed, and subsequently analysed using descriptive content analysis. SETTING: Urban and rural areas in two municipalities in Southern Norway. PARTICIPANTS: Parents of children with abdominal pain who had been referred to a local hospital by their general practitioner and had been discharged without a somatic diagnosis. Fifteen parents of 14 children aged 8-17 years who had also been interviewed in 2016. RESULTS: Nine of the children had recovered from their abdominal pain. During the pain period, the parents reported frustration with not having a diagnosis nor a specific treatment for their child's abdominal pain. The siblings in some families received less attention and were afraid that something serious might happen to their sister or brother. The parents wished that their child's school cared more about the child when they had weeks of absence. All parents maintained that their child's pain was physical, although they thought that psychological aspects might have influenced the symptoms. The parents stated that they, as well as their children, needed guidance from professionals to understand the complex pain situation. AD - General Practice Research Unit, Department of Health and Society, University of Oslo, Oslo, Norway. General Practice Research Unit, Department of Health and Society, University of Oslo, Oslo, Norway abrodwa@online.no. AN - 32868359 AU - Brekke, M. AU - Brodwall, A. C2 - PMC7462228 DA - Aug 30 DO - 10.1136/bmjopen-2020-037288 DP - NLM ET - 2020/09/02 IS - 8 KW - *Abdominal Pain Adolescent Child Follow-Up Studies Humans Male Norway Parent-Child Relations *Parents *Professional-Family Relations Qualitative Research *paediatric gastroenterology *pain management *qualitative research LA - eng N1 - 2044-6055 Brekke, Mette Orcid: 0000-0003-3454-2329 Brodwall, Anne Journal Article Research Support, Non-U.S. Gov't BMJ Open. 2020 Aug 30;10(8):e037288. doi: 10.1136/bmjopen-2020-037288. PY - 2020 SN - 2044-6055 SP - e037288 ST - Understanding parents' experiences of disease course and influencing factors: a 3-year follow-up qualitative study among parents of children with functional abdominal pain T2 - BMJ Open TI - Understanding parents' experiences of disease course and influencing factors: a 3-year follow-up qualitative study among parents of children with functional abdominal pain VL - 10 ID - 3851 ER - TY - JOUR AB - Many children report chronic abdominal pain that is severe and disruptive to normal lifestyle and schooling. Assessment and management depends on indentifying those with underlying organic disease, such as chronic infection, celiac disease or inflammatory bowel disease, but avoiding unnecessary invasive investigations. In those with a functional gut disorder, the aim of therapy is reassurance, a return to normal activity and symptom control. We address the evidence for the use of investigative and management strategies in situations where recurrent abdominal pain is likely to be a functional disorder. Epidemiological studies of European and American populations show that organic causes are uncommon, and that chronic abdominal pain is a risk factor for functional gut disorders in adulthood. There is a paucity of high quality therapeutic trials, none showing conclusive evidence of benefit. Psychological interventions, such as cognitive behavioral and family therapy are effective, reducing symptoms and improving school attendance. Asian studies suggest gastrointestinal infection, such as giardiasis, are common causes of recurrent abdominal pain, but that functional abdominal pain is also prevalent. AN - WOS:000266355900001 AU - Bremner, A. R. AU - Sandhu, B. K. DA - May IS - 5 N1 - Bremner, A. R. Sandhu, B. K. 0974-7559 PY - 2009 SN - 0019-6061 SP - 375-379 ST - Recurrent Abdominal Pain in Childhood: The Functional Element T2 - Indian Pediatrics TI - Recurrent Abdominal Pain in Childhood: The Functional Element UR - ://WOS:000266355900001 VL - 46 ID - 2603 ER - TY - JOUR AB - BACKGROUND: Lower back pain (LBP) is ranked first as a cause of disability and inability to work, and is expected to affect up to 90% of the worlds population at some point in their lifetime. The annual first time incidence of LBP is 5%, and the annual prevalence (i.e. those suffering at time of questioning) is between 15 and 63%. Prospective studies demonstrate that low back problems do not display a six-week spontaneous recovery pattern, as was once believed. The condition is regularly seen to worsen over time, becoming a chronic disorder, influenced by both physical and psychosocial factors. METHODS: The current study assessed the level of LBP amongst students engaged in educational programs that were physically demanding, and its influence on lower back problems. A 1-year retrospective questionnaire consisting of 37 closed, open and multi-choice questions was designed to ascertain self-reported information on the occurrence, cause and type of LBP. Treatment, care seeking and general knowledge regarding LBP were also recorded. Students were enrolled in BSc Equine Science, BSc Physical Education and BSc Sports & Exercise Science degree programs and a total number of 188 valid questionnaires were collected. RESULTS: The self reported, anthropometrical data for participants in this study are: age 20.9 +/- 2.7 yrs; height 171.8 +/- 9.3 cm; weight 66.7 +/- 10.4 kg; female 64% (n = 120), male 36% (n = 68). The overall self reported prevalence of LBP was 32% (n = 61). Within the LBP population, 77% reported their problem as recurring. Two factors showed significance as having an influence on LBP. They were age (21.6 +/- 3.5 yrs, p = 0.005) and hours of personal training physical activity (14.0 +/- 8.2 hrs per week, p = 0.02). LBP sufferers also displayed poor management of their condition and an interest in education and treatment of their problem. CONCLUSION: The current study revealed high prevalence of LBP consistent with that of the literature, and unveiled a recurrence rate and behavioral habits of sufferers, which are warning signs of a more chronic state to come. Novel data presented here offers strong support for the need for prospective injury tracking, plus educational intervention and treatment aimed at prevention of LBP. AD - Department of Physical Education and Sports Sciences, University of Limerick, Limerick, Ireland. graham.brennan@ul.ie AN - 17631036 AU - Brennan, G. AU - Shafat, A. AU - Mac Donncha, C. AU - Vekins, C. C2 - PMC1950501 DA - Jul 13 DO - 10.1186/1471-2474-8-67 DP - NLM ET - 2007/07/17 KW - Adult Age Factors Animal Husbandry/*education Anthropometry Chronic Disease Exercise Female Humans Ireland/epidemiology Low Back Pain/*epidemiology/etiology Male Patient Acceptance of Health Care/statistics & numerical data Patient Education as Topic *Physical Education and Training *Physical Exertion Prevalence Retrospective Studies Sampling Studies Sports/*education Students/psychology Surveys and Questionnaires Universities/statistics & numerical data LA - eng N1 - 1471-2474 Brennan, Graham Shafat, Amir Mac Donncha, Ciarán Vekins, Carmel Journal Article BMC Musculoskelet Disord. 2007 Jul 13;8:67. doi: 10.1186/1471-2474-8-67. PY - 2007 SN - 1471-2474 SP - 67 ST - Lower back pain in physically demanding college academic programs: a questionnaire based study T2 - BMC Musculoskelet Disord TI - Lower back pain in physically demanding college academic programs: a questionnaire based study VL - 8 ID - 3546 ER - TY - JOUR AB - OBJECTIVES: The aim of the study was to assess the differences in reported pain from venipuncture comparing liposomal 4% lidocaine with placebo cream in a pediatric population. Other factors assessed were patient anxiety, difficulty of venipuncture, and history of venipuncture. METHODS: A prospective, randomized, double-blind, placebo control study design was used in which subjects were assigned to receive either liposomal 4% lidocaine or placebo cream. The study population consisted of pediatric patients aged 5 to 18 years old who presented to 1 site of a multisite, academic, community emergency department. Once subjects had consented and randomized, the liposomal 4% lidocaine or placebo cream was applied for 15 minutes under occlusion. A 6-point validated FACES pain scale was used to evaluate each patient's level of pain during venipuncture. Patient anxiety was evaluated using a 100-mm visual analogue scale before, during, and after the venipuncture. Heart rate was captured as an indirect measurement of pain. RESULTS: There were no significant differences between the study and placebo groups (P > .05) in mean levels of patient ratings of anxiety, patient heart rate, or the patient's mean rating of pain before, during, or after the venipuncture procedure. There was an association between increased anxiety with an increase in venipuncture pain and an inverse association between age and pain. CONCLUSION: Topical liposomal 4% lidocaine cream in this case did not prove to be effective with a 15-minute dwell time under occlusion because there were no differences in pain between study groups. AD - Inpatient Pediatrics, Division of General Pediatrics, Case Management, Lehigh Valley Health Network, Allentown, PA, USA. AN - 22809774 AU - Brenner, S. M. AU - Rupp, V. AU - Boucher, J. AU - Weaver, K. AU - Dusza, S. W. AU - Bokovoy, J. DA - Jan DO - 10.1016/j.ajem.2012.05.003 DP - NLM ET - 2012/07/20 IS - 1 KW - Administration, Topical Adolescent Anesthetics, Local/*administration & dosage Child Child, Preschool Double-Blind Method Female Heart Rate Humans Lidocaine/*administration & dosage Linear Models Liposomes Male Pain/*etiology/*prevention & control Pain Management/*methods Pain Measurement Phlebotomy/*adverse effects/methods Placebos Prospective Studies Treatment Outcome LA - eng N1 - 1532-8171 Brenner, Scott M Rupp, Valerie Boucher, Jenny Weaver, Kevin Dusza, Stephen W Bokovoy, Joanna Journal Article Randomized Controlled Trial United States Am J Emerg Med. 2013 Jan;31(1):20-5. doi: 10.1016/j.ajem.2012.05.003. Epub 2012 Jul 16. PY - 2013 SN - 0735-6757 SP - 20-5 ST - A randomized, controlled trial to evaluate topical anesthetic for 15 minutes before venipuncture in pediatrics T2 - Am J Emerg Med TI - A randomized, controlled trial to evaluate topical anesthetic for 15 minutes before venipuncture in pediatrics VL - 31 ID - 3665 ER - TY - JOUR AB - Menometrorrhagia is a common symptom in adolescents. It is idiopathic in most cases. In case of menometrorrhagia, it is necessary to exclude a pregnancy, a disorder of hemostasis, particularly the von Willebrand disease, as it represents the most common inherited disorder, and more rarely a chronic disease or an endocrinopathy. History of the bleedings, menstrual blood loss quantification by the Higham score and tolerance of the bleedings (blood pressure) should be evaluated. Laboratory testing includes hCG, ferritin level, a complete blood count, a prothrombin time, an activated partial thromboplastin. Management of menometrorrhagia is related to the severity of the blood loss. It associates antifibrinolytics or non-steroidal anti-inflammatory agents (NSAIDS) with hormonal treatments, such as estrogen-progestin oral contraceptive pill or cyclic oral progestins. Primary or functional dysmenorrhea concerns 40 to 90% of the teenagers and represents a frequent cause of school absenteeism. Management of primary dysmenorrhea is primarily based on a treatment by NSAIDS. In case of its inefficacy or if contraception is needed hormonal treatments, such as estrogen-progestin combined pill should be prescribed. It is very important when pelvic pain is chronic and not soothed by simple medications to look for a secondary dysmenorrhea, mainly endometriosis. In such cases, pelvic magnetic resonance imaging should be performed. (C) 2013 Elsevier Masson SAS. All rights reserved. AN - WOS:000323141700019 AU - Bricaire, L. AU - Laroche, E. AU - Christin-Maitre, S. DA - Aug DO - 10.1016/j.arcped.2013.04.010 IS - 8 N1 - Bricaire, L. Laroche, E. Christin-Maitre, S. 1769-664x PY - 2013 SN - 0929-693X SP - 910-914 ST - Meno-metrorrhagia, dysmenorrhea in adolescents T2 - Archives De Pediatrie TI - Meno-metrorrhagia, dysmenorrhea in adolescents UR - ://WOS:000323141700019 VL - 20 ID - 2360 ER - TY - JOUR AB - CONTEXT: Behavioural interventions are used to prevent, manage and treat a wide variety of conditions including obesity, diabetes, chronic pain, asthma and emotional difficulties. There has been inadequate attention to the delivery of behavioural interventions to younger children (5-11 years old). OBJECTIVE: Our objectives were to describe the characteristics of behavioural interventions for children aged 5-11 years. DATA SOURCES: We searched five databases: CINAHL, EMBASE, PsycINFO, MEDLINE and Cochrane Library, from January 2005 to August 2019. STUDY SELECTION: The inclusion criteria were (1) children aged 5-11, (2) cognitive and/or behavioural interventions, (3) randomised controlled trials and (4) 2005 onward. Two researchers independently identified studies for inclusion. DATA EXTRACTION: Two researchers independently extracted data from eligible papers. RESULTS: The search identified 10 541 papers. We extracted information on 117 interventions (from 152 papers). Many of the interventions were categorised as complex. This was particularly true for clinical populations; 78.7% were delivered to both the child and parent, and 33.9% took place across multiple settings, typically health and school settings. Most (70.9%) were 'First Wave' (behavioural) interventions, and few (4.3%) were 'Third Wave' (characterised by metacognition, acceptance and mindfulness). Thirty-nine per cent used interactive techniques (play, arts, story and/or games). Purely digital and paper-based interventions were rare, but around a third used these tools as supplements to face-face delivery. There were differences in interventions for younger (5-7 years) and older (8-11 years) children. CONCLUSIONS: Interventions designed and delivered to children should be developmentally sensitive. This review highlights characteristics of interventions delivered to children 5-11 years old: the involvement of the child's parent, using behavioural (rather than cognitive) modalities, using interactive techniques and some interventions were delivered across multiple settings. AD - Centre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UK. Department of Psychology, University of Bath, Bath, Somerset, UK. Bristol Medical School, University of Bristol, Bristol, UK. AN - 31909219 AU - Brigden, A. AU - Parslow, R. M. AU - Linney, C. AU - Higson-Sweeney, N. AU - Read, R. AU - Loades, M. AU - Davies, A. AU - Stoll, S. AU - Beasant, L. AU - Morris, R. AU - Ye, S. AU - Crawley, E. C2 - PMC6937047 DO - 10.1136/bmjpo-2019-000543 DP - NLM ET - 2020/01/08 IS - 1 KW - child psychology comm child health general paediatrics health service paediatric practice LA - eng N1 - 2399-9772 Brigden, Amberly Orcid: 0000-0002-7958-7881 Parslow, Roxanne Morin Linney, Catherine Higson-Sweeney, Nina Read, Rebecca Loades, Maria Davies, Anna Stoll, Sarah Beasant, Lucy Morris, Richard Ye, Siyan Crawley, Esther Orcid: 0000-0002-2521-0747 DRF-2016-09-021/DH_/Department of Health/United Kingdom DRF-2017-10-169/DH_/Department of Health/United Kingdom SRF-2013-06-013/DH_/Department of Health/United Kingdom Journal Article BMJ Paediatr Open. 2019 Dec 10;3(1):e000543. doi: 10.1136/bmjpo-2019-000543. eCollection 2019. PY - 2019 SN - 2399-9772 SP - e000543 ST - How are behavioural interventions delivered to children (5-11 years old): a systematic mapping review T2 - BMJ Paediatr Open TI - How are behavioural interventions delivered to children (5-11 years old): a systematic mapping review VL - 3 ID - 4213 ER - TY - JOUR AB - Psychosomatic symptoms are by definition clinical symptoms with no underlying organic pathology. Common symptoms seen in pediatric age group include abdominal pain, headaches, chest pain, fatigue, limb pain, back pain, worry about health and difficulty breathing. These, more frequently seen symptoms should be differentiated from somatoform or neurotic disorders seen mainly in adults. The prevalence of psychosomatic complaints in children and adolescents has been reported to be between 10 and 25%. These symptoms are theorized to be a response to stress. Potential sources of stress in children and adolescents include schoolwork, family problems, peer pressure, chronic disease or disability in parents, family moves, psychiatric disorder in parents and poor coping abilities. Characteristics that favour psychosomatic basis for symptoms include vagueness of symptoms, varying intensity, inconsistent nature and pattern of symptoms, presence of multiple symptoms at the same time, chronic course with apparent good health, delay in seeking medical care, and lack of concern on the part of the patient. A thorough medical and psychosocial history and physical examination are the most valuable aspects of diagnostic evaluation. Organic etiology for the symptoms must be ruled out. Appropriate mental health consultation should be considered for further evaluation and treatment. AD - Overlook Hospital Children's Medical Centre, Summit, New Jersey and Michigan State University, Kalamazoo Centre for Medical Studies, Kalamazoo, Michigan, USA. AN - 11519281 AU - Brill, S. R. AU - Patel, D. R. AU - MacDonald, E. DA - Jul DO - 10.1007/bf02752270 DP - NLM ET - 2001/08/25 IS - 7 KW - Abdominal Pain/*diagnosis Adolescent Child Diagnosis, Differential Female Headache/*diagnosis Humans Hyperventilation/*diagnosis Incidence Male Psychophysiologic Disorders/*diagnosis/epidemiology Risk Assessment LA - eng N1 - Brill, S R Patel, D R MacDonald, E Case Reports Journal Article Review India Indian J Pediatr. 2001 Jul;68(7):597-603. doi: 10.1007/BF02752270. PY - 2001 SN - 0019-5456 (Print) 0019-5456 SP - 597-603 ST - Psychosomatic disorders in pediatrics T2 - Indian J Pediatr TI - Psychosomatic disorders in pediatrics VL - 68 ID - 3828 ER - TY - JOUR AB - BACKGROUND: Headaches affect most children and rank third among illness-related causes of school absenteeism. Although the short-term outcome for most children appears favorable, few studies have reported long-term outcome. OBJECTIVE: To evaluate the long-term prognosis of childhood headaches 20 years after initial diagnosis in a cohort of Atlantic Canadian children who had headaches diagnosed in 1983. METHODS: Ninety-five patients with headaches who consulted 1 of the authors in 1983 were previously studied in 1993. The 77 patients contacted in 1993 were followed up in 2003. A standardized interview protocol was used. RESULTS: Sixty (78%) of 77 patients responded (60 of the 95 of the original cohort). At 20-year follow-up, 16 (27%) were headache free, 20 (33%) had tension-type headaches, 10 (17%) had migraine, and 14 (23%) had migraine and tension-type headaches. Having more than 1 headache type was more prevalent than at diagnosis or initial follow-up (P<.001), and headache type varied across time. Of those with headaches at follow-up, 80% (35/44) described their headaches as moderate or severe, although an improvement in headaches was reported by 29 (66%). Tension-type headaches were more likely than migraine to remit (P<.04). Headache severity at diagnosis was predictive of headache outcome at 20 years. During the month before follow-up, nonprescription medications were used by 31 (70%) of those with ongoing headaches, and prescription medications were used by 6 (14%). However, 20 (45%) believed that nonpharmacological methods were most effective. Medication use increased during the 10 years since last follow-up. No patient used selective serotonin receptor agonists (triptans). CONCLUSIONS: Twenty years after diagnosis of pediatric headache, most patients continue to have headache, although the headache classification often changes across time. Most patients report moderate or severe headache and increasingly choose to care for their headaches pharmacologically. AD - Division of Pediatric Neurology, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. pbrna@hotmail.com AN - 16330740 AU - Brna, P. AU - Dooley, J. AU - Gordon, K. AU - Dewan, T. DA - Dec DO - 10.1001/archpedi.159.12.1157 DP - NLM ET - 2005/12/07 IS - 12 KW - Canada/epidemiology Child Disease Progression Female Follow-Up Studies Humans Male Migraine Disorders/*diagnosis/epidemiology Pain Measurement Prevalence Prognosis Retrospective Studies Severity of Illness Index Tension-Type Headache/*diagnosis/epidemiology Time Factors LA - eng N1 - Brna, Paula Dooley, Joseph Gordon, Kevin Dewan, Tammie Comparative Study Journal Article United States Arch Pediatr Adolesc Med. 2005 Dec;159(12):1157-60. doi: 10.1001/archpedi.159.12.1157. PY - 2005 SN - 1072-4710 (Print) 1072-4710 SP - 1157-60 ST - The prognosis of childhood headache: a 20-year follow-up T2 - Arch Pediatr Adolesc Med TI - The prognosis of childhood headache: a 20-year follow-up VL - 159 ID - 3607 ER - TY - JOUR AB - Sickle cell anaemia in children is characterised by recurrent crises that frequently involve intensive medical care which may impact on the health and well-being of their carers. The psychosocial impact of sickle cell disease on 67 carers of children with sickle cell disease attending the Paediatric Haematology/Oncology clinic of the University College Hospital, Ibadan, Nigeria, was determined between February and May 2007 using a structured questionnaire adapted from an instrument earlier validated for the study of carer burden in sickle cell disease and relevant to the Nigerian culture. Data analysis was performed using the Statistical Package for Social Sciences (SPSS) version 15.0. Demographic factors as well as frequency of hospitalisations and blood transfusions were each categorised into groups and the Mann-Whitney U-test was used to test for differences in stress scores between any two groups while the Kruskal-Wallis test was used to test for differences in more than two groups. Level of statistical significance was set at P < 0.05. Family finances were adversely affected in 39 (58.2%) families. Financial stress was frequently associated with a history of two or more hospitalisations in the previous year and more so in families with more than three children. Majority (80.6%) of the carers said they had minimal or no difficulty coping with their children. There was also a significant correlation between financial stress and difficulty in parental coping. Caring for the illnesses in the children often caused disruptions in family interactions; worst in the first year after diagnosis and improved over the years. Regular assessment of psychosocial areas of need is necessary to guide provision of necessary support. AN - WOS:000276861500008 AU - Brown, B. J. AU - Okereke, J. O. AU - Lagunju, A. AU - Orimadegun, A. E. AU - Ohaeri, J. U. AU - Akinyinka, O. O. DA - May DO - 10.1111/j.1365-2524.2009.00903.x IS - 3 N1 - Brown, B. J. Okereke, J. O. Lagunju, A. Orimadegun, A. E. Ohaeri, J. U. Akinyinka, O. O. Orimadegun, Adebola E/H-9330-2013 Orimadegun, Adebola E/0000-0001-5590-0039; Akinyinka, Olusegun/0000-0001-6752-8502 1365-2524 PY - 2010 SN - 0966-0410 SP - 289-295 ST - Burden of health-care of carers of children with sickle cell disease in Nigeria T2 - Health & Social Care in the Community TI - Burden of health-care of carers of children with sickle cell disease in Nigeria UR - ://WOS:000276861500008 VL - 18 ID - 2554 ER - TY - JOUR AB - Parents with chronic pain have a higher likelihood of having depression and anxiety and more often have children with these conditions. Depressive and anxious symptoms in children worsen pain-related disability and may be derived from exposure to their parents' symptoms. We assessed a model of intergenerational chronic pain-related disability that relies upon depressive and anxious symptoms of a mother and their child. Adolescents in grades 5 to 10 from 5 schools, and their mothers, completed standardized electronic questionnaires about pain. In maternal-offspring dyads (n = 1179), the mean offspring age was 12.7 years (SD = 1.7, range = 10-17) and 51% were girls. Logistic regression was used to investigate mother-offspring associations of chronic pain presence, and mediation models using multiple linear regression were used to investigate the proposed model. Adolescents of mothers with chronic pain had 1.67 (95% confidence interval [CI] = 1.29-2.16) times increased odds of chronic pain, with each year of exposure to maternal chronic pain associated with a 5% (odds ratio 95% CI = 1.01-1.10) increased likelihood of offspring chronic pain. Worse maternal pain-related disability was associated with worse offspring pain-related disability (beta = 0.20, 95% CI = 0.06-0.34). The mediation model indicated maternal and adolescent offspring symptoms of depression explained 36% of the relationship between maternal and offspring pain-related disability, with 11% explained by the intergenerational transmission of depression (serial mediation). We conclude that worse pain-related disability is associated between parent and child, and that depressive symptoms common to both mother and child play a key role in this relationship. AN - WOS:000656632900030 AU - Brown, D. AU - Rosenthal, N. AU - Konning, A. AU - Wager, J. DA - Feb DO - 10.1097/j.pain.0000000000002066 IS - 2 N1 - Brown, Donnamay Rosenthal, Nicola Koenning, Anna Wager, Julia 1872-6623 PY - 2021 SN - 0304-3959 SP - 653-662 ST - Intergenerational transmission of chronic pain-related disability: the explanatory effects of depressive symptoms T2 - Pain TI - Intergenerational transmission of chronic pain-related disability: the explanatory effects of depressive symptoms UR - ://WOS:000656632900030 VL - 162 ID - 1757 ER - TY - JOUR AB - BACKGROUND: Concussion literature and treatment guidelines are inconclusive regarding the role of sex in symptom reporting at baseline and post-concussion. Although empirical evidence is lacking, it is generally regarded that females have a more severe symptomatic presentation than males at all time-points on the concussion spectrum. OBJECTIVES: Our objective was to determine whether differences exist between males and females at baseline (pre-season/before concussion) or post-concussion for self-reported (1) prevalence of individual symptoms and (2) total symptom scores in high school and college athletes. DESIGN: Systematic review and meta-analysis of observational cohort studies; level of evidence, 1. METHODS: A computerized search of the PubMed, SPORTDiscus, CINAHL, and Scopus databases was performed. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines were followed. Criteria for inclusion were (1) self-report of symptoms at any time within the concussion spectrum, including baseline and after concussion, (2) study sample included high school and/or collegiate athletes aged 12-26 years, (3) concussions occurred during participation in sport, and (4) symptom reporting was separated by sex. The Quality Assessment Tool for Cohort Studies, Q-Coh, was utilized for quality assessment. RESULTS: Twenty-one studies met the criteria for inclusion: seventeen had good quality and four, acceptable quality. At baseline, females had significantly higher odds than males of reporting the individual symptoms of vision/hearing problems, headache/migraine, difficulty concentrating, energy/sleep disturbances, and emotional disturbances. Post-concussion, only one symptom demonstrated significant differences between males and females, with females demonstrating lower odds of reporting confusion than males. Statistically, at baseline and post-concussion, females had significantly higher total symptom scores on the Post-Concussion Scale (PCS) and the Sport Concussion Assessment Tool 2 (SCAT2), but when the standard mean difference was interpreted after back-transformation, these results were clinically insignificant. CONCLUSIONS: The symptomatic presentation of males and females, most notably the prevalence of specific symptoms, is very divergent. Females had higher total symptom scores at baseline and post-concussion, however, clinically this cannot be interpreted as a meaningful difference. It is possible that these differences can be explained by normal hormonal changes associated with the menstrual cycle. The implications of these findings are that symptomatic presentation during an individual female's menstrual cycle needs to be taken into consideration post-concussion when making return-to-play decisions, as returning to a completely asymptomatic level may not be a reasonable expectation. AD - Division of Health Sciences, Physical Therapy Program, Walsh University, 2020 E Maple Street, North Canton, OH, 44720, USA. AN - 25971368 AU - Brown, D. A. AU - Elsass, J. A. AU - Miller, A. J. AU - Reed, L. E. AU - Reneker, J. C. DA - Jul DO - 10.1007/s40279-015-0335-6 DP - NLM ET - 2015/05/15 IS - 7 KW - Affective Symptoms/etiology Athletic Injuries/*diagnosis Brain Concussion/*diagnosis Cognition Disorders/etiology Dizziness/etiology Fatigue/etiology Female Headache/etiology Hearing Disorders/etiology Humans Male Migraine Disorders/etiology Sex Factors Sleep Wake Disorders/etiology Vision Disorders/etiology LA - eng N1 - 1179-2035 Brown, Dana A Elsass, Julie A Miller, Ashley J Reed, Lauren E Reneker, Jennifer C Journal Article Meta-Analysis Review Systematic Review New Zealand Sports Med. 2015 Jul;45(7):1027-40. doi: 10.1007/s40279-015-0335-6. PY - 2015 SN - 0112-1642 SP - 1027-40 ST - Differences in Symptom Reporting Between Males and Females at Baseline and After a Sports-Related Concussion: A Systematic Review and Meta-Analysis T2 - Sports Med TI - Differences in Symptom Reporting Between Males and Females at Baseline and After a Sports-Related Concussion: A Systematic Review and Meta-Analysis VL - 45 ID - 3936 ER - TY - JOUR AB - In recent years, fibromyalgia has become an increasingly recognized chronic syndrome. Although it occurs more frequently in adults, it is also seen among school-age children and adolescents. In such cases, it is known as juvenile fibromyalgia syndrome (JFS). The widespread pain and other possible symptoms associated with JFS can have a negative impact on the occupational performance and developmental tasks of children and adolescents. As experts in the areas of occupational performance, daily functional skills, and child development, occupational therapists have a potential role to play in the assessment and management of children and adolescents with JFS. To date, however, no occupational therapy management approach for clients with JFS has been documented in the professional literature. In this paper, we outline the clinical features of JFS, pertinent assessment areas, and potential management strategies using a cognitive-behavioral approach. AD - Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada K1H 8L1. AN - 11715801 AU - Brown, G. T. AU - Delisle, R. AU - Gagnon, N. AU - Sauvé, A. E. DP - NLM ET - 2001/11/22 IS - 1 KW - Adolescent Chronic Disease Cognitive Behavioral Therapy/*methods Female Fibromyalgia/complications/*rehabilitation Humans Pain/etiology *Pain Management Patient Care Planning Social Support LA - eng N1 - Brown, G T Delisle, R Gagnon, N Sauvé, A E Case Reports Journal Article Review England Phys Occup Ther Pediatr. 2001;21(1):19-36. PY - 2001 SN - 0194-2638 (Print) 0194-2638 SP - 19-36 ST - Juvenile fibromyalgia syndrome: proposed management using a cognitive-behavioral approach T2 - Phys Occup Ther Pediatr TI - Juvenile fibromyalgia syndrome: proposed management using a cognitive-behavioral approach VL - 21 ID - 3410 ER - TY - JOUR AB - Background: Chronic pain is a frequent burden in the general population. Child maltreatment and bullying are risk factors for the development of chronic pain. Aim of this cross-sectional study was to investigate the association of child maltreatment and bullying and pain experiences in a representative sample of the general population. Materials and methods: A total of N= 2,491 people from the general population of Germany participated in the study (M-age = 48.3 years [SD= 18.2], 53.2 % female). Child maltreatment was assessed with the Childhood Trauma Questionnaire (CTQ), pain was rated with the Polytrauma Outcome (POLO)-physical state domain, depression scores were assessed with the Patient Health Questionnaire, and anxiety scores via the General Anxiety Disorder Questionnaire. Regression analyses were calculated to investigate the effect of bullying and child maltreatment, as well as depression, anxiety, and gender on pain experiences. Results: A significant correlation between increasing pain levels and number of adverse childhood experiences was found. With regard to specific types of maltreatment, largest effect sizes were found for emotional abuse. Bullying was significantly, but overall rather moderately, related to pain suffering. In women, all forms of maltreatment were associated with pain, while in men only sexual and physical abuse revealed significant effects. Although depression and anxiety scores were significantly associated with the experience of current pain, they did not change the effect of child maltreatment on pain significantly. Conclusion: In this sample of the general population, adverse childhood experiences were significantly associated with pain and showed cumulative effects, over and above depressive and anxiety symptoms. AN - WOS:000452738400002 AU - Brown, R. C. AU - Plener, P. L. AU - Braehler, E. AU - Fegert, J. M. AU - Huber-Langs, M. DO - 10.2147/jpr.S169135 N1 - Brown, Rebecca C. Plener, Paul L. Braehler, Elmar Fegert, Joerg M. Huber-Langs, Markus Braehler, Elmar/C-6535-2009; Fegert, Jorg M./AAY-2959-2020 Braehler, Elmar/0000-0002-2648-2728; Plener, Paul/0000-0003-4333-1494 PY - 2018 SN - 1178-7090 SP - 3099-3108 ST - Associations of adverse childhood experiences and bullying on physical pain in the general population of Germany T2 - Journal of Pain Research TI - Associations of adverse childhood experiences and bullying on physical pain in the general population of Germany UR - ://WOS:000452738400002 VL - 11 ID - 2040 ER - TY - BOOK A2 - Finley, G. A. A2 - McGrath, P. J. A2 - Chambers, C. T. AB - This chapter reviews literature pertaining to the management of pain within the school setting. Etiological issues underlying obstacles to school attendance are reviewed, including issues pertaining to make-up work, concerns among many children pertaining to use of the bathroom at school, diet and eating habits at school, relationship with a teacher or peer, fear of pain episodes at school, learning problems, test or performance anxiety, separation anxiety, and familial reinforcement of sick behavior. Interventions to increase school attendance are reviewed; these also include a careful assessment of the child and the family system, the use of behavioral interventions, as well as other treatment approaches, including the use of relaxation therapy and problem-solving therapy. Finally, specific directions for future research efforts and training also are provided. AN - WOS:000237541600005 AU - Brown, R. T. DO - 10.1007/978-1-59745-125-3_5 N1 - Brown, Ronald T. 5th Biennial International Forum on Pediatric Pain - Bringing Pain Relief to Children Oct 14-17, 2004 Nova Scotia, CANADA Brown, Ronald/0000-0002-9656-4614 PY - 2006 SN - 1-58829-628-8 SP - 113-129 ST - Managing pediatric pain at school T2 - Bringing Pain Relief to Children: Treatment Approaches TI - Managing pediatric pain at school UR - ://WOS:000237541600005 ID - 2745 ER - TY - JOUR AB - Background and Aims: Functional bowel disorders (FBD), such as irritable bowel syndrome (IBS), are increasingly more common in children and affect up to 20% of children. The etiology is multifactorial with no clear organic cause. Symptoms are recurrent and are associated with a reduced quality of life, school absences, and psychological challenges. Treatment options are variable. FODMAPs are short-chained carbohydrates, poorly absorbed by the gastrointestinal tract due to their increased osmotic activity and excess gas production from the bacterial fermentation process. There is a paucity of data examining dietary interventions that restrict carbohydrates in children with IBS. The aim of this study was to examine the use of the low FODMAP diet (LFD) in children with an FBD. Methods: A retrospective clinical case note review of children with an FBD managed with an LFD was undertaken. Anthropometry and clinical data were collected by a pediatric gastroenterology dietitian. An IBS satisfaction survey was used to assess diet outcomes. Statistical analyses were completed using Excel. Results: Of the 29 children included in this study, complete resolution of gastrointestinal symptoms was observed for 11 of 12 (92%) of those with bloating, 13 of 15 (87%) of those with diarrhea, and 17 of 22 (77%) of those with abdominal pain. Twenty-three (79%) participants reported an improvement of symptoms. Fructans were the most common symptom-causing carbohydrate. Conclusion: The LFD is a useful dietary treatment strategy for children with FBD. This study adds to the small body of evidence supporting FODMAP dietary interventions in children with FBD. Further prospective studies are required. AN - WOS:000626747900009 AU - Brown, S. C. AU - Whelan, K. AU - Gearry, R. B. AU - Day, A. S. DA - Apr DO - 10.1002/jgh3.12231 IS - 2 N1 - Brown, Stephanie C. Whelan, Kevin Gearry, Richard B. Day, Andrew S. Gearry, Richard B/H-3959-2019 Gearry, Richard B/0000-0002-2298-5141; Whelan, Kevin/0000-0001-5414-2950 PY - 2020 SN - 2397-9070 SP - 153-159 ST - Low FODMAP diet in children and adolescents with functional bowel disorder: A clinical case note review T2 - Jgh Open TI - Low FODMAP diet in children and adolescents with functional bowel disorder: A clinical case note review UR - ://WOS:000626747900009 VL - 4 ID - 1834 ER - TY - JOUR AB - Introduction The treatment of chronic functional nausea or nausea due to functional dyspepsia in children is generally symptomatic. Moreover, these disorders pose a risk for worse psychosocial and health outcomes in children. Hypnotherapy (HT), by its ability to positively influence gastrointestinal and psychosocial functioning, may be an effective treatment for chronic nausea. Methods and analysis To test efficacy, this multicentre, parallel, randomised controlled, open label trial evaluates whether gut-directed HT is superior to standard medical treatment (SMT) for reducing nausea. The study will be conducted at eleven academic and non-academic hospitals across the Netherlands. A total of 100 children (8-18 years), fulfilling the Rome IV criteria for chronic idiopathic nausea or functional dyspepsia with prominent nausea, will be randomly allocated (1: 1) to receive HT or SMT. Children allocated to the HT group will receive six sessions of HT during 3 months, while children allocated to the SMT group will receive six sessions of SMT+supportive therapy during the same period. The primary outcome will be the difference in the proportion of children with at least 50% reduction of nausea, compared with baseline at 12 months' follow-up. Secondary outcomes include the changes in abdominal pain, dyspeptic symptoms, quality of life, anxiety, depression, school absences, parental absence of work, healthcare costs and adequate relief of symptoms, measured directly after treatment, 6 and 12 months' follow-up. If HT proves effective for reducing nausea, it may become a new treatment strategy to treat children with chronic functional nausea or functional dyspepsia with prominent nausea. Ethics and dissemination Results of the study will be publicly disclosed to the public, without any restrictions, in peer-reviewed journal and international conferences. The study is approved by the Medical Research Ethics Committees United (MEC-U) in the Netherlands. Trial registration number NTR5814. AN - WOS:000471157200081 AU - Browne, P. D. AU - den Hollander, B. AU - Speksnijder, E. M. AU - van Wering, H. M. AU - Ten, W. T. A. AU - George, E. K. AU - Groeneweg, M. AU - Bevers, N. AU - Wessels, M. M. S. AU - Van den Berg, M. M. AU - Goede, J. AU - Teklenburg-Roord, S. T. A. AU - Frankenhuis, C. AU - Benninga, M. A. AU - Vlieger, A. M. C7 - e024903 DA - Jun DO - 10.1136/bmjopen-2018-024903 IS - 4 N1 - Browne, Pamela D. den Hollander, Bibiche Speksnijder, Esther M. van Wering, Herbert M. Ten, Walther Tjon A. George, Elvira K. Groeneweg, Michael Bevers, Nanja Wessels, Margaretha M. S. Van den Berg, Maartje M. Goede, Joery Teklenburg-Roord, Sarah T. A. Frankenhuis, Carla Benninga, Marc A. Vlieger, Arine M. vlieger, arine/ABE-8079-2020 den Hollander, Bibiche/0000-0003-1544-2402 PY - 2019 SN - 2044-6055 ST - Gut-directed hypnotherapy versus standard medical treatment for nausea in children with functional nausea or functional dyspepsia: protocol of a multicentre randomised trial T2 - Bmj Open TI - Gut-directed hypnotherapy versus standard medical treatment for nausea in children with functional nausea or functional dyspepsia: protocol of a multicentre randomised trial UR - ://WOS:000471157200081 VL - 9 ID - 1913 ER - TY - JOUR AB - OBJECTIVE: To describe the development of a clinically and financially successful interdisciplinary pediatric pain rehabilitation program at a large tertiary academic medical center and present demographic and clinical information on the first 1000 patients. PATIENTS AND METHODS: All patients who were consecutively admitted to this program between October 1, 2008, and March 31, 2015 were included in this review. The patients ranged in age from 9 to 24 years. The program is a 3-week, hospital-based outpatient treatment program that requires substantial parental involvement. At admission and discharge, patients completed the Center for Epidemiologic Studies of Depression Scale for Children, the Functional Disability Inventory, and the Pain Catastrophizing Scale for Children. Opioid use was also assessed. RESULTS: At admission, patients reported substantial pain-associated disability and depressive symptoms; they had elevated pain catastrophizing scores, and 16% were taking opioids. Primary sites/types of pain included head, abdomen, and generalized. Functional disability scores decreased significantly, from 27 to 9 after the program (P<.001). Depression scale scores improved from 27 to 14 (P<.001). Pain catastrophizing scores decreased significantly, from 26 to 14 (P<.001), at discharge from the program. All but 4 patients successfully tapered off of all opioid use by the conclusion of the program. CONCLUSION: Participation in a multidisciplinary pediatric pain rehabilitation program can be successful, with significant decreases in disability, depression symptoms, and pain catastrophizing, as well as discontinuation of opioid use. AD - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN. Division of Pediatric Anesthesia, Department of Anesthesia, Mayo Clinic, Rochester, MN. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN. AN - 30225410 AU - Bruce, B. K. AU - Weiss, K. E. AU - Ale, C. M. AU - Harrison, T. E. AU - Fischer, P. R. C2 - PMC6135035 DA - Sep DO - 10.1016/j.mayocpiqo.2017.05.006 DP - NLM ET - 2017/07/26 IS - 2 KW - CBT, cognitive behavioral therapy POTS, postural orthostatic tachycardia syndrome LA - eng N1 - 2542-4548 Bruce, Barbara K Weiss, Karen E Ale, Chelsea M Harrison, Tracy E Fischer, Philip R Journal Article Mayo Clin Proc Innov Qual Outcomes. 2017 Jul 26;1(2):141-149. doi: 10.1016/j.mayocpiqo.2017.05.006. eCollection 2017 Sep. PY - 2017 SN - 2542-4548 SP - 141-149 ST - Development of an Interdisciplinary Pediatric Pain Rehabilitation Program: The First 1000 Consecutive Patients T2 - Mayo Clin Proc Innov Qual Outcomes TI - Development of an Interdisciplinary Pediatric Pain Rehabilitation Program: The First 1000 Consecutive Patients VL - 1 ID - 4072 ER - TY - JOUR AB - In this nationwide study, 1975 students from grades 3, 6, and 9 (ages 9, 12, and 15 at the onset of the year), were recruited from randomly selected schools, which represented different geographical areas throughout Sweden. The main aim of the study was to assess the prevalence of self-reported pain (headache, abdominal, and musculoskeletal pain) and perceived health (problems sleeping and/or if they often felt tired, lonely and sad). A second aim was to study the co-occurrence among different pain and health variables. The students, (n = 1908 distributed by grade 3: 255 girls and 305 boys, grade 6: 347 girls and 352 boys, grade 9: 329 girls and 320 boys) answered retrospectively (three months) a specially designed questionnaire. Fifty percent (50%) of the students reported that they had experienced pain, either as headache, abdominal pain or musculoskeletal pain, within the recall period. Gender differences were especially noticeable for headaches, where twice as many girls (17%, n = 159) than boys (8%, n = 80) reported that they suffered such pain at least once a week or more often. Co-occurrence among the variables was moderate (0.3-0.5). For the total of the seven variables, the perception of pain and health complaints decreased with age for boys from grades 3 to 9, while multiple complaints increased for girls. AU - Brun Sundblad, Gunilla M. AU - Saartok, Tönu AU - Engström, Lars-Magnus T. DA - 2007/02// DO - 10.1016/j.ejpain.2006.02.006 DP - PubMed IS - 2 J2 - Eur J Pain KW - Abdominal Pain Adolescent Age Distribution Attitude to Health Child Depression Fatigue Female Headache Humans Loneliness Male Musculoskeletal Diseases Prevalence Retrospective Studies Sex Characteristics Sex Distribution Sleep Wake Disorders Surveys and Questionnaires Sweden LA - eng PY - 2007 SN - 1090-3801 SP - 171-180 ST - Prevalence and co-occurrence of self-rated pain and perceived health in school-children T2 - European Journal of Pain (London, England) TI - Prevalence and co-occurrence of self-rated pain and perceived health in school-children: Age and gender differences UR - http://www.ncbi.nlm.nih.gov/pubmed/16542860 VL - 11 ID - 116 ER - TY - JOUR AB - Background: Headache and sleep are related in different ways and alterations of chronobiological mechanisms are involved in headache. We investigated the relationships between headache and sleep quality in a large non-clinical population of children and adolescents and evaluated the relationship between headache and circadian typologies. Methods: A total of 1073 children and adolescents (50.9% males; mean age = 10.56; range = 8-15 years) were recruited from four schools in Rome. They filled out the questionnaires individually in classrooms, after brief group instruction about answer formats. The questionnaires included (a) a self-report headache questionnaire to collect information on different aspects of headache attacks based on the International Classification of Headache Disorders-2nd edition (ICHD-2); (b) the School Sleep Habits Survey that incorporated questions about sleep habits, the Sleep-Wake Problems Behaviour Scale (SWPBS), the Sleepiness Scale (SLS) and the Morningness/Eveningness Questionnaire (MEQ). Results: According to ICHD-2 criteria, we classified 70 (6.5%) children as Migraine Group (MG), 135 (12.7%) as Non-Migraine Headache Group (NMG), and the remaining 868 (80.8%) were classified as Headache-Free Group (HFG). No clear differences have been found between MG and NMG regarding the frequency of the attacks, although MG showed a significantly increased frequency of long-lasting attacks. The modality of onset of pain and the location of pain was similar in both groups. The most frequent triggering factor for headache in MG and NMG was "a bad sleep" (32.2%) followed by emotional distress (27.8%). No differences have been found between MG, NMG and HFG in sleep schedule or sleep duration. MG and NMG showed significantly higher scores on the SWPBS vs. HFG, while MG presented higher scores on the SLS compared to NMG and HFG. MG presented lower MEQ scores, indicating a more pronounced eveningness. Conclusions: The relationships between headache and sleep problems are evident even in a non-clinical population of children and adolescents, with MG showing poorer sleep quality, sleepiness and a tendency toward eveningness. (C) 2007 Elsevier B.V. All rights reserved. AN - WOS:000257913100013 AU - Bruni, O. AU - Russo, P. M. AU - Ferri, R. AU - Novelli, L. AU - Galli, F. AU - Guidetti, V. DA - Jul DO - 10.1016/j.sleep.2007.08.010 IS - 5 N1 - Bruni, O. Russo, P. M. Ferri, R. Novelli, L. Galli, F. Guidetti, V. Ferri, Raffaele/B-5439-2013; Galli, Federica/AAL-5452-2020; Russo, Paolo/AAO-5351-2021; Bruni, Oliviero/A-4029-2008 Ferri, Raffaele/0000-0001-6937-3065; Bruni, Oliviero/0000-0003-2207-1398; Guidetti, Vincenzo/0000-0003-1643-8392; RUSSO, PAOLO MARIA/0000-0002-0575-5360; Galli, Federica/0000-0003-0491-0338 1878-5506 PY - 2008 SN - 1389-9457 SP - 542-548 ST - Relationships between headache and sleep in a non-clinical population of children and adolescents T2 - Sleep Medicine TI - Relationships between headache and sleep in a non-clinical population of children and adolescents UR - ://WOS:000257913100013 VL - 9 ID - 2644 ER - TY - JOUR AB - Recurrent abdominal pain (RAP) is one of the most common health complaints in both children and adults. Although RAP is considered a functional disorder rather than an organic disease, affected children and their families can still experience anxiety and concerns that can interfere with school, sports, and regular daily activities and lead to frequent attendances at pediatric emergency departments or pediatric gastroenterology clinics. Our review shows experts do not agree on a universally proven management that will work on every child presenting with functional abdominal pain (FAP). Treatment strategies include both non-pharmacological and pharmacological options. Non-pharmacological treatments are usually very well accepted by both children and their parents and are free from medication side effects. Nevertheless, they may be as effective as the pharmacological interventions; therefore, according to many experts and based on the majority of current evidence, a non-pharmacological approach should be the first intervention attempt in children with RAP. In particular, the importance of the bio-psychosocial approach is highlighted, as a majority of children will improve with counselling and reassurance that no serious organic pathologies are suspected, especially when the physician establishes a trustful relationship with both the child and their family. Placebo and pharmacological interventions could be attempted when the bio-psychosocial approach is not applicable or not efficacious. In some difficult cases, finding an effective treatment for FAP can be a challenge, and a number of strategies may need to be tried before symptoms are controlled. In these cases, a multidisciplinary team, comprising a pediatric gastroenterologist, dietician, psychologist, and psychotherapist, is likely to be successful. AN - WOS:000432367500004 AU - Brusaferro, A. AU - Farinelli, E. AU - Zenzeri, L. AU - Cozzali, R. AU - Esposito, S. DA - Jun DO - 10.1007/s40272-018-0287-z IS - 3 N1 - Brusaferro, Andrea Farinelli, Edoardo Zenzeri, Letizia Cozzali, Rita Esposito, Susanna zenzeri, letizia/AAA-8190-2019; Farinelli, Edoardo/V-3854-2019; Esposito, Susanna/K-3475-2016 zenzeri, letizia/0000-0001-5220-680X; Esposito, Susanna/0000-0003-4103-2837; Farinelli, Edoardo/0000-0002-6075-0554 1179-2019 PY - 2018 SN - 1174-5878 SP - 235-247 ST - The Management of Paediatric Functional Abdominal Pain Disorders: Latest Evidence T2 - Pediatric Drugs TI - The Management of Paediatric Functional Abdominal Pain Disorders: Latest Evidence UR - ://WOS:000432367500004 VL - 20 ID - 2014 ER - TY - JOUR AB - Pain and fear widely contribute to negative experiences for students during school-based immunizations. In this preliminary research, we used a pre-existing network of 50 schools across Canada that participated in a biannual national immunization poster competition for grade 6 students organized by Immunize Canada to survey principals, teachers and students about their experiences with immunization pain and fear, how they want to learn about managing pain and fear and opportunities to include this information in the process of immunization. Responses revealed that both pain and fear are relevant to the immunization experience and that education and interventions are welcome by students and school staff. This may lead to improved attitudes about immunization, as well as future compliance with recommended immunizations. AN - WOS:000401441000013 AU - Bucci, L. M. AU - MacDonald, N. E. AU - Sondagar, C. AU - Taddio, A. DA - Mar DO - 10.1093/pch/pxx004 IS - 1 N1 - Bucci, Lucie Marisa MacDonald, Noni E. Sondagar, Chandni Taddio, Anna PY - 2017 SN - 1205-7088 SP - 41-42 ST - Taking the sting out of school-based immunizations T2 - Paediatrics & Child Health TI - Taking the sting out of school-based immunizations UR - ://WOS:000401441000013 VL - 22 ID - 2105 ER - TY - JOUR AB - Pediatric headache is an increasingly reported phenomenon. Cervicogenic headache (CGH) is a subgroup of headache, but there is limited information about cervical spine physical examination signs in children with CGH. Therefore, a cross-sectional study was designed to investigate cervical spine physical examination signs including active range of motion (ROM), posture determined by the craniovertebral angle (CVA), and upper cervical ROM determined by the flexion-rotation test (FRT) in children aged between 6 and 12 years. An additional purpose was to determine the degree of pain provoked by the FRT. Thirty children (mean age 120.70 months [SD 15.14]) with features of CGH and 34 (mean age 125.38 months [13.14]) age-matched asymptomatic controls participated in the study. When compared to asymptomatic controls, symptomatic children had a significantly smaller CVA (p < 0.001), significantly less active ROM in all cardinal planes (p < 0.001), and significantly less ROM during the FRT (p < 0.001), especially towards the dominant headache side (p < 0.001). In addition, symptomatic subjects reported more pain during the FRT (p < 0.001) and there was a significant negative correlation (r = -0.758, p < 0.001) between the range recorded during the FRT towards the dominant headache side and FRT pain intensity score. This study found evidence of impaired function of the upper cervical spine in children with CGH and provides evidence of the clinical utility of the FRT when examining children with CGH. AN - WOS:000324816900010 AU - Budelmann, K. AU - von Piekartz, H. AU - Hall, T. DA - Oct DO - 10.1007/s00431-013-2046-z IS - 10 N1 - Budelmann, Kim von Piekartz, Harry Hall, Toby von Piekartz, Harry/I-4163-2019 von Piekartz, Harry/0000-0002-4509-929X; Hall, Toby/0000-0003-4461-7259 1432-1076 PY - 2013 SN - 0340-6199 SP - 1349-1356 ST - Is there a difference in head posture and cervical spine movement in children with and without pediatric headache? T2 - European Journal of Pediatrics TI - Is there a difference in head posture and cervical spine movement in children with and without pediatric headache? UR - ://WOS:000324816900010 VL - 172 ID - 2345 ER - TY - JOUR AB - Background: Headache is a public health problem affecting life quality negatively. The present cross-sectional, selective (2nd-5th grades) study was conducted to determine the prevalence of recurrent headache in schoolchildren in Mersin, a city of Turkey. Methods: A stratified sample of 5777 students was selected to be representative of the city's schoolchildren population. After the data quality control process, the study sample was reduced to 5562 schoolchildren. Result: The prevalence of recurrent headache was 49.2% (2739/5562). Among the studied population 24.7% had tension-type headache and 10.4% had migraine. Girls had significantly more frequent headache than boys. Binary logistic regression analysis found that increasing age, female gender, low socioeconomic status of family, low education level of mother, and positive family history of headache (father, mother, siblings, second degree relatives) had a statistically significant effect on the presence of headache in children. Additionally, having travel sickness had a statistically significant effect on schoolchildren headache (P = 0.000). Conclusion: Headache is a common health problem among schoolchildren in Mersin, which merits increased attention and detailed multicentre epidemiological and clinical studies. AN - WOS:000229190200016 AU - Bugdayci, R. AU - Ozge, A. AU - Sasmaz, T. AU - Kurt, A. O. AU - Kaleagasi, H. AU - Karakelle, A. AU - Tezcan, H. AU - Siva, A. DA - Jun DO - 10.1111/j.1442-200x.2005.02051.x IS - 3 N1 - Bugdayci, R Ozge, A Sasmaz, T Kurt, AO Kaleagasi, H Karakelle, A Tezcan, H Siva, A Sasmaz, Tayyar/I-6090-2015; Siva, Aksel/A-5132-2016; Bugdayci, Resul/G-7530-2018 Sasmaz, Tayyar/0000-0002-3923-570X; Siva, Aksel/0000-0002-8340-6641; 1442-200x PY - 2005 SN - 1328-8067 SP - 316-322 ST - Prevalence and factors affecting headache in Turkish schoolchildren T2 - Pediatrics International TI - Prevalence and factors affecting headache in Turkish schoolchildren UR - ://WOS:000229190200016 VL - 47 ID - 2762 ER - TY - JOUR AB - The present preliminary study was aimed at investigating the electrocortical correlates of attentional allocation toward emotional stimuli in children and adolescents with migraine by means of the event-related potentials. The electroencephalogram was continuously recorded in 7 migrainous children and 8 healthy controls while they were looking at a series of pleasant, neutral, and unpleasant pictures. The mean amplitude of the Negative Central component of the event-related potentials was computed as an index of the allocation of attentional resources to the presented stimuli. Relative to controls, children with migraine displayed reduced fronto-central negativity and larger posterior positivity in response to emotional pictures. This effect was already evident, overall, in a time window preceding the Negative Central component. The smaller cortical negativity in response to emotional stimuli suggests reduced attentional engagement toward emotionally relevant stimuli, or might be interpreted in terms of advanced brain maturation in migraine children. AN - WOS:000297312100006 AU - Buodo, G. AU - Sarlo, M. AU - Battistella, P. A. AU - Naccarella, C. AU - Palomba, D. DA - Dec DO - 10.1177/0883073811408905 IS - 12 N1 - Buodo, Giulia Sarlo, Michela Battistella, Pier Antonio Naccarella, Cristiana Palomba, Daniela Sarlo, Michela/AAP-4606-2020; Buodo, Giulia/D-1229-2014; Sarlo, Michela/I-7414-2012 Sarlo, Michela/0000-0001-6652-7604; Buodo, Giulia/0000-0002-8701-248X; Sarlo, Michela/0000-0001-6652-7604; Palomba, Daniela/0000-0003-1656-4209 1708-8283 PY - 2011 SN - 0883-0738 SP - 1508-1515 ST - Event-Related Potentials to Emotional Stimuli in Migrainous Children T2 - Journal of Child Neurology TI - Event-Related Potentials to Emotional Stimuli in Migrainous Children UR - ://WOS:000297312100006 VL - 26 ID - 2467 ER - TY - JOUR AB - OBJECTIVE: Guidelines recommend that clinicians make decisions about opioid tapering for patients with chronic pain using a benefit-to-harm framework and engaging patients. Studies have not examined clinician documentation about opioid tapering using this framework. DESIGN AND SETTING: Thematic and content analysis of clinician documentation about opioid tapering in patients' medical records in a large academic health system. METHODS: Medical records were reviewed for patients aged 18 or older, without cancer, who were prescribed stable doses of long-term opioid therapy between 10/2015 and 10/2016 then experienced an opioid taper (dose reduction ≥30%) between 10/2016 and 10/2017. Inductive thematic analysis of clinician documentation within six months of taper initiation was conducted to understand rationale for taper, and deductive content analysis was conducted to determine the frequencies of a priori elements of a benefit-to-harm framework. RESULTS: Thematic analysis of 39 patients' records revealed 1) documented rationale for tapering prominently cited potential harms of continuing opioids, rather than observed harms or lack of benefits; 2) patient engagement was variable and disagreement with tapering was prominent. Content analysis found no patients' records with explicit mention of benefit-to-harm assessments. Benefits of continuing opioids were mentioned in 56% of patients' records, observed harms were mentioned in 28%, and potential harms were mentioned in 90%. CONCLUSIONS: In this study, documentation of opioid tapering focused on potential harms of continuing opioids, indicated variable patient engagement, and lacked a complete benefit-to-harm framework. Future initiatives should develop standardized ways of incorporating a benefit-to-harm framework and patient engagement into clinician decisions and documentation about opioid tapering. AD - Department of Medicine, Albert Einstein College of Medicine and Montefiore Health System, Bronx, New York. Department of Physical Medicine and Rehabilitation, New York-Presbyterian Columbia/Cornell, New York, New York. Department of Emergency Medicine, SUNY Downstate Medical Center, Brooklyn, New York. Center for Research on Healthcare, Divisions of General Internal Medicine and Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AN - 32142143 AU - Buonora, M. AU - Perez, H. R. AU - Stumph, J. AU - Allen, R. AU - Nahvi, S. AU - Cunningham, C. O. AU - Merlin, J. S. AU - Starrels, J. L. C2 - PMC7593794 DA - Oct 1 DO - 10.1093/pm/pnz361 DP - NLM ET - 2020/03/07 IS - 10 KW - Adolescent *Analgesics, Opioid *Chronic Pain/drug therapy Documentation Humans Medical Records Patient Participation *Chronic Pain *Clinician Documentation *Opioid Taper *Pain Management *Primary Care LA - eng N1 - 1526-4637 Buonora, Michele Perez, Hector R Stumph, Jordan Allen, Robert Nahvi, Shadi Cunningham, Chinazo O Merlin, Jessica S Starrels, Joanna L K23 DA044327/DA/NIDA NIH HHS/United States K24 DA036955/DA/NIDA NIH HHS/United States UL1 TR001073/TR/NCATS NIH HHS/United States UL1 TR002556/TR/NCATS NIH HHS/United States K24 DA046309/DA/NIDA NIH HHS/United States R01 DA039046/DA/NIDA NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Pain Med. 2020 Oct 1;21(10):2574-2582. doi: 10.1093/pm/pnz361. PY - 2020 SN - 1526-2375 (Print) 1526-2375 SP - 2574-2582 ST - Medical Record Documentation About Opioid Tapering: Examining Benefit-to-Harm Framework and Patient Engagement T2 - Pain Med TI - Medical Record Documentation About Opioid Tapering: Examining Benefit-to-Harm Framework and Patient Engagement VL - 21 ID - 3048 ER - TY - JOUR AB - OBJECTIVE: To study the differences in levels of alexithymia, depression, and anxiety between a sample of adolescents diagnosed with ICD-10 persistent somatoform pain disorder (defined by the DSM-IV as a pain disorder associated with psychological factors) and healthy adolescent control subjects. METHOD: Using the Toronto Alexithymia Scale and the Hospital Anxiety and Depression Scale, we investigated the point prevalence of alexithymia, anxiety, and depression among adolescents aged 12 to 17 years, with somatoform disorder, who were hospitalized in Kaunas Medical University Hospital, Lithuania (n =120), and a healthy control group (n = 60) of adolescents aged 12 to 17 years, who were randomly selected from 6 schools in Kaunas, Lithuania. RESULTS: The rate of alexithymia in adolescents with somatoform disorder was 59%, which was significantly higher than that in healthy control subjects (1%, P < 0.001). Similarly, the rate of anxiety was significantly higher in the patient group (62%), compared with control subjects (15%, P < 0.001). The rate of depression was low in both groups and did not differ significantly between groups. CONCLUSIONS: Adolescents with somatoform disorder have higher levels of alexithymia and anxiety than healthy adolescent control subjects, but adolescents with somatoform disorder and adolescent control subjects do not have significantly different levels of depression. AD - Department of Psychiatry, Kaunas Medical University Hospital, Lithuania. AN - 16838829 AU - Burba, B. AU - Oswald, R. AU - Grigaliunien, V. AU - Neverauskiene, S. AU - Jankuviene, O. AU - Chue, P. DA - Jun DO - 10.1177/070674370605100709 DP - NLM ET - 2006/07/15 IS - 7 KW - Adolescent Affective Symptoms/*diagnosis/epidemiology/psychology Anxiety Disorders/diagnosis/epidemiology/psychology Child Chronic Disease Comorbidity Cross-Sectional Studies Depressive Disorder/diagnosis/epidemiology/psychology Female Humans Lithuania Male Pain/epidemiology/*psychology Personality Inventory/statistics & numerical data Psychometrics/statistics & numerical data Reference Values Somatoform Disorders/*diagnosis/epidemiology/psychology LA - eng N1 - Burba, Benjaminas Oswald, Ronald Grigaliunien, Viktorija Neverauskiene, Simona Jankuviene, Odeta Chue, Pierre Journal Article United States Can J Psychiatry. 2006 Jun;51(7):468-71. doi: 10.1177/070674370605100709. PY - 2006 SN - 0706-7437 (Print) 0706-7437 SP - 468-71 ST - A controlled study of alexithymia in adolescent patients with persistent somatoform pain disorder T2 - Can J Psychiatry TI - A controlled study of alexithymia in adolescent patients with persistent somatoform pain disorder VL - 51 ID - 3567 ER - TY - JOUR AB - Neonatal injury is associated with persistent changes in sensory function and altered nociceptive thresholds that give rise to aberrant pain sensitivity in later life. Although these changes are well documented in adult rodents, little is known about the consequences of neonatal injury during adolescence. Because adolescence is a critical developmental period during which persistent pain conditions can arise, we examined the effect of neonatal injury on nociception, social behavior, and response to morphine in adolescent Sprague Dawley rats. Male and female rats exposed to plantar incision injury at postnatal day 3 displayed mechanical hypersensitivity that resolved by 24 hours after incision. When these animals reached adolescence (postnatal day 28-40), neonatally -injured male rats showed ipsilaterally restricted mechanical, heat, and cold hypersensitivity, as well as social behavioral deficits. In contrast, these effects were not seen in female rats. Neonatal injury did not alter acute morphine antinociception or the development of analgesic tolerance in either sex. Morphine-induced conditioned place preference, behavioral sensitization, and physical withdrawal were also not affected by neonatal incision. Thus, early-life injury results in sex-dependent pain related hypersensitivity and social behavior deficits during adolescence, without altering the response to opioids. Perspective: Neonatal surgery has greater effects on adolescent male than female rats, resulting in pain-related hypersensitivity and social behavioral deficits. Neonatal surgery does not alter the anti-nociceptive effects of morphine or abuse liability. (C) 2017 by the American Pain Society AN - WOS:000414381400010 AU - Burke, N. N. AU - Trang, T. DA - Nov DO - 10.1016/j.jpain.2017.07.003 IS - 11 N1 - Burke, Nikita N. Trang, Tuan Burke, Nikita/AAX-2647-2020 Burke, Nikita/0000-0001-8688-1512 PY - 2017 SN - 1526-5900 SP - 1384-1396 ST - Neonatal Injury Results in Sex-Dependent Nociceptive Hypersensitivity and Social Behavioral Deficits During Adolescence, Without Altering Morphine Response T2 - Journal of Pain TI - Neonatal Injury Results in Sex-Dependent Nociceptive Hypersensitivity and Social Behavioral Deficits During Adolescence, Without Altering Morphine Response UR - ://WOS:000414381400010 VL - 18 ID - 2065 ER - TY - JOUR AB - OBJECTIVE: To examine the efficacy and safety of conservative management of mild otitis media ("the acute red ear") in children. DESIGN: Double blind placebo controlled trial. SETTING: 17 group general practices (48 general practitioners) in Southampton, Bristol, and Portsmouth. PATIENTS: 232 children aged 3-10 years with acute earache and at least one abnormal eardrum (114 allocated to receive antibiotic, 118 placebo). INTERVENTIONS: Amoxycillin 125 mg three times a day for seven days or matching placebo; 100 ml paracetamol 120 mg/5 ml. MAIN OUTCOME MEASURES: Diary records of pain and crying, use of analgesic, eardrum signs, failure of treatment, tympanometry at one and three months, recurrence rate, and ear, nose, and throat referral rate over one year. RESULTS: Treatment failure was eight times more likely in the placebo than the antibiotic group (14.4% v 1.7%, odds ratio 8.21, 95% confidence interval 1.94 to 34.7). Children in the placebo group showed a significantly higher incidence of fever on the day after entry (20% v 8%, p less than 0.05), mean analgesic consumption (0.36 ml/h v 0.21 ml/h, difference 0.14, 95% confidence interval 0.07 to 0.23; p = 0.0022), mean duration of crying (1.44 days v 0.50 days, 0.94; 0.50 to 1.38; p less than 0.001), and mean absence from school (1.96 days v 0.52 days, 1.45; 0.46 to 2.42; p = 0.0132). Differences in recorded pain were not significant. The prevalence of middle ear effusion at one or three months, as defined by tympanometry, was not significantly different, nor was there any difference in recurrence rate or in ear, nose, and throat referral rate in the follow up year. No characteristics could be identified which predicted an adverse outcome. CONCLUSIONS: Use of antibiotic improves short term outcome substantially and therefore continues to be an appropriate management policy. AD - Primary Medical Care Group, University of Southampton, Aldermoor Health Centre. AN - 1912887 AU - Burke, P. AU - Bain, J. AU - Robinson, D. AU - Dunleavey, J. C2 - PMC1670875 DA - Sep 7 DO - 10.1136/bmj.303.6802.558 DP - NLM ET - 1991/09/07 IS - 6802 KW - Acetaminophen/*therapeutic use Acoustic Impedance Tests Acute Disease Amoxicillin/*therapeutic use Child Child, Preschool Crying Double-Blind Method Earache/drug therapy/etiology Female Humans Male Otitis Media/*drug therapy Prognosis Recurrence Referral and Consultation Time Factors LA - eng N1 - 1468-5833 Burke, P Bain, J Robinson, D Dunleavey, J Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't BMJ. 1991 Sep 7;303(6802):558-62. doi: 10.1136/bmj.303.6802.558. PY - 1991 SN - 0959-8138 (Print) 0959-8138 SP - 558-62 ST - Acute red ear in children: controlled trial of non-antibiotic treatment in general practice T2 - Bmj TI - Acute red ear in children: controlled trial of non-antibiotic treatment in general practice VL - 303 ID - 3592 ER - TY - JOUR AB - This paper introduces an empirically derived psychosocial assessment form that may facilitate the incorporation of the growing body of research on sickle cell into the psychosocial assessment process. The psychosocial assessment form was guided by two theoretical models that explain the variability in adjustment among children and adolescents with sickle cell-the Disability-Stress-Coping Model (Wallender, Varni, Babani, Banis, & Wilcox, 1989) and the Transactional Stress and Coping Model (Thompson, Gustafson, George Spock, 1994). The Psychosocial Assessment Form consists of two sections. The first section includes primary indicators of adjustment such as internalizing disorders, externalizing disorders, school performance, and difficulties in social relationships. The second section lists secondary indicators of adjustment including intrapersonal. factors, stress processing factors, and social ecological factors. The literature that guided this form is also reviewed. (C) 2002 by The Haworth Press, Inc. All rights reserved. AN - WOS:000179742000003 AU - Burlew, A. K. DO - 10.1300/J010v36n01_03 IS - 1 N1 - Burlew, AK 1541-034x PY - 2002 SN - 0098-1389 SP - 29-44 ST - Empirically derived guidelines for assessing the psychosocial needs of children and adolescents with sickle cell T2 - Social Work in Health Care TI - Empirically derived guidelines for assessing the psychosocial needs of children and adolescents with sickle cell UR - ://WOS:000179742000003 VL - 36 ID - 2842 ER - TY - JOUR AB - Objective: This guideline reviews the investigation and treatment of primary dysmenorrhea. Intended Users: Health care providers. Target Population: Women and adolescents experiencing menstrual pain for which no underlying cause has been identified. Evidence: Published clinical trials, population studies, and review articles cited in PubMed or the Cochrane database from January 2005 to March 2016. Validation Methods: Seven clinical questions were generated by the authors and reviewed by the SOGC Clinical Practice-Gynaecology Committee. The available literature was searched. Guideline No. 169 was reviewed and rewritten in order to incorporate current evidence. Recommendations addressing the identified clinical questions were formulated and evaluated using the ranking of the Canadian Task Force on Preventive Health Care. [GRAPHICS] . Benefits, Harms, and Costs: Primary dysmenorrhea is common and frequently undertreated. Effective therapy is widely available at minimal cost. Treatment has the potential to improve quality of life and to decrease time lost from school or work. Guideline Update: This guideline is a revision and update of No. 169, December 2005. Sponsors: SOGC. Summary Statements 1. Dysmenorrhea is highly prevalent and commonly undertreated (III). 2. Non-steroidal anti-inflammatory drugs are more effective than placebo but have more gastrointestinal side effects. All currently available non-steroidal anti-inflammatory drugs are of comparable efficacy and safety (I). 3. Suppression of ovulation is associated with decreased menstrual pain (II-1). 4. Amenorrhea induced by any means is beneficial for the treatment of dysmenorrhea (II-2). 5. Hysterectomy is effective treatment (II-2). 6. There is some evidence to support laparoscopic nerve ablation in selected cases (II-1). 7. Endometrial ablation is likely to reduce symptoms of dysmenorrhea when it occurs in the presence of menorrhagia (I). Recommendations 1. Both primary and secondary dysmenorrhea are likely to respond to the same medical therapy. Therefore, initiation of treatment should not depend on establishing a precise diagnosis (II-1A). 2. Health care providers should include specific questions regarding menstrual pain when obtaining a woman's medical history (III-B). 3. A pelvic examination is not necessary prior to initiating therapy (III-D). 4. A pelvic examination is indicated in patients not responding to conventional therapy and when organic pathology is suspected (III-B). 5. Non-steroidal anti-inflammatory drugs, administered with regular dosing regimens, should be considered first-line treatment for most women (I-A). 6. Hormonal therapies should be offered to women and girlswho are not currently planning pregnancy unless contraindications exist (I-A). 7. Continuous or extended use combined hormonal contraceptives are recommended (I-A). 8. Regular exercise is likely to improve symptoms of dysmenorrhea and should be recommended (II-1A). 9. Local heat in the form of heated pads or patches should be recommended as a complementary treatment for dysmenorrhea (I-A). 10. High-frequency transcutaneous electrical nerve stimulation should be considered as a complementary treatment or in women unable or unwilling to use conventional therapy (II-1B). 11. Acupoint stimulation should be considered for women wishing to use complementary or alternative therapies (II-1B). 12. Ginger is recommended for women wishing to use complementary or alternative therapies (I-A). 13. Preoperative investigations should include a detailed history and physical examination, ultrasound, and possibly magnetic resonance imaging to discover secondary causes for dysmenorrhea and to direct appropriate therapy (III-A). 14. Surgical intervention should only be considered if a concerted trial of medical therapy has not been successful (III-A). AN - WOS:000443572100016 AU - Burnett, M. AU - Lemyre, M. DA - Jul DO - 10.1016/j.jogc.2016.12.023 IS - 7 N1 - Burnett, Margaret Lemyre, Madeleine PY - 2017 SN - 1701-2163 SP - 585-595 ST - No. 345-Primary Dysmenorrhea Consensus Guideline T2 - Journal of Obstetrics and Gynaecology Canada TI - No. 345-Primary Dysmenorrhea Consensus Guideline UR - ://WOS:000443572100016 VL - 39 ID - 2090 ER - TY - JOUR AB - Summary of the concepts of prevention in low back pain (LBP): The general nature and course of commonly experienced LBP means that there is limited scope for preventing its incidence (first-time onset). Prevention, in the context of this guideline, is focused primarily on reduction of the impact and consequences of LBP. Primary causative mechanisms remain largely undetermined: risk factor modification will not necessarily achieve prevention. There is considerable scope, in principle, for prevention of the consequences of LBP - e.g. episodes (recurrence), care seeking, disability, and workloss. Different interventions and outcomes will be appropriate for different target populations (general population, workers, and children) yet inevitably there is overlap. Interventions that are essentially treatments in the clinical environment, focused on management of current symptoms, are not considered as 'prevention' for the purposes of this guideline: they are covered in the accompanying clinical guidelines Overarching comments: Overall, there is limited robust evidence for numerous aspects of prevention in LBP. Nevertheless, there is evidence suggesting that prevention of various consequences of LBP is feasible. However, for those interventions where there is acceptable evidence, the effect sizes are rather modest. The most promising approaches seem to involve physical activity/exercise and appropriate (biopsychosocial) education, at least for adults. But, no single intervention is likely to be effective to prevent the overall problem of LBP, owing to its multidimensional nature. Prevention in LBP is a societal as well as an individual concern. So, optimal progress on prevention in LBP will likely require a cultural shift in the way LBP is viewed, its relationship with activity and work, how it might best be tackled, and just what is reasonable to expect from preventive strategies. It is important to get all the players onside, but innovative studies are required to understand better the mechanisms and delivery of prevention in LBP. Anecdotally, individuals may report that various strategies work for them, but in the absence of scientific evidence that does not mean they can be generally recommended for prevention, it is not known whether some of these strategies have disadvantageous long- term effects. Recommendations: These are based on systematic reviews, existing evidence-based guidelines, and scientific studies. The studies on which these recommendations are based were often variable and imprecise in specifying the interventions and outcomes investigated. Hence, it is not always possible to state exactly which outcomes will be influenced by a given intervention. Summary of recommendations for the general population: Physical exercise is recommended for prevention of sick leave due to LBP and for the occurrence or duration of further episodes (Level A). There is insufficient consistent evidence to recommend for or against any specific type or intensity of exercise (Level C). Information and education about back problems, if based on biopsychosocial principles, should be considered (Level C), but information and education focused principally on a biomedical or biomechanical model cannot be recommended (Level C). Back schools based on traditional biomedical/biomechanical information, advice and instruction are not recommended for prevention in LBP (Level A). High intensity programmes, which comprise both an educational/skills programme and exercises, can be recommended for patients with recurrent and persistent back pain (Level B). Lumbar supports or back belts are not recommended (Level A). There is no robust evidence for or against recommending any specific chair or mattress for prevention in LBP (Level C), though persisting symptoms may be reduced with a mediurn-firm rather than a hard mattress (Level C). There is no evidence to support recommending manipulative treatment for prevention in LBP (Level D). Shoe insoles are not recommended in the prevention of back problems (Level A). There is insufficient evidence to recommend for or against correction of leg length (Level D). Summary of recommendations for workers: Physical exercise is recommended in the prevention of LBP (Level A), for prevention of recurrence of LBP (Level A) and for prevention of recurrence of sick leave due to LBP (Level Q. There is insufficient evidence to recommend for or against any specific type or intensity of exercise (Level C). Back schools based on traditional biomedical/biomechanical information, advice and instruction are not recommended for prevention in LBP (Level A). There is insufficient evidence to recommend for or against psychosocial information delivered at the worksite (Level C), but information oriented toward promoting activity and improving coping may promote a positive shift in beliefs (Level C). Lumbar supports or back belts are not recommended (Level A). Shoe inserts/orthoses are not recommended (Level A). There is insufficient evidence to recommend for or against in-soles, soft shoes, soft flooring or antifatigue mats (Level D). Temporary modified work and ergonomic workplace adaptations can be recommended to facilitate earlier return to work for workers sick listed due to LBP (Level B). There is insufficient consistent evidence to recommended physical ergonomics interventions alone for prevention in LBP (Level C). There is some evidence that, to be successful, a physical ergonomics programme would need an organisational dimension and involvement of the workers (Level B); there is insufficient evidence to specify precisely the useful content of such interventions (Level C). There is insufficient consistent evidence to recommend stand-alone work organisational interventions (Level C), yet such interventions could, in principle, enhance the effectiveness of physical ergonomics programmes. Whilst multidimensional interventions at the workplace can be recommended (Level A), it is not possible to recommend which dimensions and in what balance. Summary of recommendations for school age: There is insufficient evidence to recommend for or against a generalized educational intervention for the prevention of LBP or its consequences in schoolchildren (Level C). Despite the intuitive appeal of the idea, there is no evidence that attempts to prevent LBP in schoolchildren will have any impact on LBP in adults (Level D). Summary of recommendations for further research: It is recommended that the following approaches are considered for further research into prevention in low back pain. Future studies need to be of high quality; where possible that should be in the form of randomised controlled trials. It is also recommended that standards of evidence criteria for efficacy, effectiveness and dissemination should be taken into account (Society for Prevention Research 2004). As a general recommendation, it is considered important that future studies include cost-benefit and risk-benefit analyses. General Studies are needed to determine how and by whom interventions are best delivered to specific target groups. Good quality RCTs are needed to determine the effectiveness of specific interventions aimed at specific risk /target groups. Misconceptions about back pain are shown to be widespread in adults, and they play a role in the development of long-term disability (Goubert et al. 2004). Further study is necessary to explore whether these misconceptions may be prevented by carefully selected and presented health promotion programmes, with the merit of demedicalising LBP. More information is needed to match types of interventions with specific/relevant outcomes. High quality studies are recommended into the effectiveness of specific furniture to justify or refute claims by commercial interests. Workers Good quality RCTs are needed to study the effectiveness of daily physical activity for prevention of LBP and for prevention of recurrence of LBP. In addition, the effectiveness of physical exercise as well as daily physical activity should be studied for prevention of (recurrence of) sick leave due to LBP. It is recommended to perform good quality RCTs on the role of information oriented toward reducing fear avoidance beliefs and improving coping strategies in the prevention of LBP. Good quality RCTs are urgently needed to study the effectiveness of physical, psychosocial and organisational ergonomic interventions on a large variety of outcomes, ranging from prevention of (recurrence of) LBP and prevention of (recurrence of) sick leave due to LBP up to compensable LBP. It is recommended to investigate whether effective interventions can be applied to all workers, irrespective of gender, age, seniority and/or past history of LBP. If the effective interventions have to be more tailor-made, the optimal approach for each relevant subgroup should be examined. School age RCTs evaluating the possible positive effects of preventive programmes and risk factor modifications at young age on adult LBP are advocated. From a physiological point of view, poor life style habits and prolonged static sitting during school age on unadjusted furniture may play a role in the origin of LBP: further study is appropriate to determine any effectiveness of school-based interventions (exercise/sport, desks/seating, backpacks/bags). Further study with a follow-up into adulthood is needed to evaluate whether or not the physical cumulative load experience on the lumbar spine (e.g. from heavy book-bag carrying or sitting on unadjusted furniture) during childhood and adolescence contributes to adult LBP. AN - WOS:000237742400003 AU - Burton, A. K. AU - Balague, F. AU - Cardon, G. AU - Eriksen, H. R. AU - Henrotin, Y. AU - Lahad, A. AU - Leclerc, A. AU - Muller, G. AU - van der Beek, A. J. AU - Pr, Cost B. Working Grp Guidelines DA - Mar DO - 10.1007/s00586-006-1070-3 N1 - Burton, A. K. Balague, F. Cardon, G. Eriksen, H. R. Henrotin, Y. Lahad, A. Leclerc, A. Muller, G. van der Beek, A. J. Burton, Kim/0000-0002-9462-2227 1432-0932 2 PY - 2006 SN - 0940-6719 SP - S136-S168 ST - Chapter 2 - European guidelines for prevention in low back pain T2 - European Spine Journal TI - Chapter 2 - European guidelines for prevention in low back pain UR - ://WOS:000237742400003 VL - 15 ID - 2738 ER - TY - JOUR AB - OBJECTIVE: To determine the prevalence of pain complaints, specifically of chronic widespread pain, in the general population; and to explore the utilization of health services by various pain groups. METHODS: Cross sectional population survey of 2210 adults in the southern part of Israel, who were classified into 5 pain groups: no pain, transient pain, chronic regional pain, chronic widespread pain, and other. Participants were interviewed about pain patterns and utilization of health services. RESULTS: Forty-four percent reported pain on the day of the interview. The prevalence of chronic widespread pain in the study population was 9.9%, 14% in women and 3% in men (p<0.01). The prevalence in the Israeli adult population was estimated after adjusting for sex and age as 10.2%. The prevalence of any chronic pain (regional or widespread) increased with age. The prevalence of chronic widespread pain was significantly higher in women than in men across all age groups (p<0.01). Persons with chronic widespread pain reported most frequent visits to their physicians (10.8 visits/year) and most frequent use of antiinflammatory and analgesic drugs. They were more frequently referred to specialists and tended to be hospitalized slightly more often. CONCLUSION: In the general population in Israel, widespread pain is common, and its prevalence is comparable with reports from USA, UK, and Canada. AD - Epidemiology Department, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer-Sheva, Israel. AN - 10852282 AU - Buskila, D. AU - Abramov, G. AU - Biton, A. AU - Neumann, L. DA - Jun DP - NLM ET - 2000/06/14 IS - 6 KW - Absenteeism Adolescent Adult Age Distribution Aged Aged, 80 and over Analgesics/therapeutic use Chronic Disease Comorbidity Cross-Sectional Studies Female Hospitals/*statistics & numerical data Humans Israel/epidemiology Male Middle Aged Pain/drug therapy/*epidemiology Physicians' Offices/*statistics & numerical data Prevalence Sex Distribution LA - eng N1 - Buskila, D Abramov, G Biton, A Neumann, L Journal Article Canada J Rheumatol. 2000 Jun;27(6):1521-5. PY - 2000 SN - 0315-162X (Print) 0315-162x SP - 1521-5 ST - The prevalence of pain complaints in a general population in Israel and its implications for utilization of health services T2 - J Rheumatol TI - The prevalence of pain complaints in a general population in Israel and its implications for utilization of health services VL - 27 ID - 3389 ER - TY - JOUR AB - Objective: Our aim was to examine and map the consequences of chronic pain in children and adolescents. Method: A scoping review was carried out in the international databases (PubMed, SCOPUS, WOS and CINAHL, Cochrane Library) and gray literature. We included documents that addressed psychosocial aspects that influence chronic pain, published in English between 2010 and 2016. We excluded the documents that dealt with pharmacological treatments, chronic pain derived from surgical interventions or where there was no access to full text. 34 of the 716 documents reviewed were included. Results: Studies show that pain is associated with high rates of functional disability, sleep disorders and spectrum depression-anxiety. Young people experience higher rates of victimization and stigmatization, contributing to social isolation, difficulty in meeting academic demands and less opportunity to consume illegal substances. With respect to the family, chronic pain has been associated with poorer family functioning and considerable investment of economic resources. Conclusions: This Scoping Review shows that functional capacity, sleep, personal development, peer support and family functioning are interesting lines in published works. However, gaps in knowledge are detected in areas such as risk behaviours, the consequences that pain can cause in adulthood and gender inequalities. (C) 2018 SESPAS. Published by Elsevier Espana, This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgilicenses/by-nc-nd/4.0/). AN - WOS:000465490700012 AU - Caceres-Matos, R. AU - Gil-Garcia, E. AU - Barrientos-Trigo, S. AU - Molina, E. AU - Porcel-Galvez, A. M. DA - May-Jun DO - 10.1016/j.gaceta.2017.11.007 IS - 3 N1 - Caceres-Matos, Rocio Gil-Garcia, Eugenia Barrientos-Trigo, Sergio Molina, Esther Maria Porcel-Galvez, Ana Barrientos-Trigo, Sergio/M-4640-2018; Molina, Esther/J-2847-2018; Galvez, Ana Maria Porcel/AAM-6081-2020; Gil-Garcia, Eugenia/K-5181-2017 Barrientos-Trigo, Sergio/0000-0001-7618-3091; Molina, Esther/0000-0002-0771-7608; Gil-Garcia, Eugenia/0000-0003-3862-6845 1578-1283 PY - 2019 SN - 0213-9111 SP - 272-282 ST - Consequences of chronic pain in childhood and adolescence T2 - Gaceta Sanitaria TI - Consequences of chronic pain in childhood and adolescence UR - ://WOS:000465490700012 VL - 33 ID - 1927 ER - TY - JOUR AB - OBJECTIVES: Treatment for childhood leukemia requires frequent lumbar punctures (LP) and bone marrow aspirations (BMA), often described by children and parents as more distressing than the disease itself. Findings in schoolchildren and chronic pain samples indicate that increased parental distress may increase parental protective, pain-attending behavior, which is associated with more child pain and distress. However, in the context of invasive medical procedures, it is unknown which parents are likely to become most distressed and engage in pain-attending behavior, and how this impacts the children's experiences. The present study investigated the impact of parental catastrophic thoughts upon parental distress and pain-attending behavior (verbal and nonverbal). Furthermore, the association between parental responses and the children's pain behavior, pain, and distress was examined. MATERIALS AND METHODS: A total of 46 parents of children with leukemia (range, 0.6 to 15 y) who underwent a LP/BMA procedure participated in this study. Parental catastrophizing was assessed before and parental and child distress was assessed after the LP/BMA procedure. Parental pain-attending behavior and the child's pain behavior were observed before and after the LP/BMA procedure. RESULTS: Findings indicated that heightened parental catastrophic thinking contributed to increased parental distress during LP/BMA and less pain-attending behavior before the LP/BMA procedure, especially in young children. In contrast, heightened distress in parents with high levels of catastrophizing contributed to increased engagement in postprocedural pain-attending behavior. For young children, increased preprocedural pain-attending behavior was related to more child distress, pain, and pain behavior. DISCUSSION: The findings demonstrate the importance of parental catastrophic thinking in understanding their caregiving responses and preparing parents and children for painful invasive medical procedures. AD - *Centre for Pediatric Pain Research, IWK Health Centre, Halifax, Nova Scotia, Canada †Department of Experimental-Clinical and Health Psychology, Ghent University ‡Department of Pediatric Oncology/Hematology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium. AN - 24042348 AU - Caes, L. AU - Vervoort, T. AU - Devos, P. AU - Verlooy, J. AU - Benoit, Y. AU - Goubert, L. DA - Sep DO - 10.1097/ajp.0000000000000028 DP - NLM ET - 2013/09/18 IS - 9 KW - Adolescent Adult Age Factors Bone Marrow Purging/adverse effects/psychology *Catastrophization Child Child, Preschool Female Humans Infant Leukemia/*physiopathology/psychology/therapy Male Middle Aged Pain/etiology/*physiopathology/psychology Parent-Child Relations Parents/*psychology Spinal Puncture/adverse effects/psychology *Stress, Psychological Young Adult LA - eng N1 - 1536-5409 Caes, Line Vervoort, Tine Devos, Patricia Verlooy, Joris Benoit, Yves Goubert, Liesbet Journal Article Research Support, Non-U.S. Gov't United States Clin J Pain. 2014 Sep;30(9):787-99. doi: 10.1097/AJP.0000000000000028. PY - 2014 SN - 0749-8047 SP - 787-99 ST - Parental distress and catastrophic thoughts about child pain: implications for parental protective behavior in the context of child leukemia-related medical procedures T2 - Clin J Pain TI - Parental distress and catastrophic thoughts about child pain: implications for parental protective behavior in the context of child leukemia-related medical procedures VL - 30 ID - 3979 ER - TY - JOUR AB - Background: The elderly population is growing in Turkey, as it is worldwide. The average age of residents in rural areas of Turkey is relatively high and is gradually increasing. The purpose of this study is to summarize the fitness and frailty of elderly adults living in a rural area of Turkey characterized by a relatively low level of socioeconomic development. Material/Methods: This study was designed as a prospective, cross-sectional study, and was conducted in a rural area of Kars Province. A total of 168 elderly adults (>= 65 years old) from 12 central villages were included in the study. The Fried Frailty Criteria was used to assess the frailty of the participants. In addition to frailty, the physical, social, and mental status of elderly adults was examined. Results: The prevalence of frailty in this rural area of Turkey was 7.1%. The study group ranged in age from 65 to 96 years (mean 72.70 +/- 7.73 years), and 53.6% were female. Among the elderly adult group, 84.3% had not completed elementary school, and 43.29% had a monthly income of <= 500 Turkish liras ($200). No significant relationship was identified between gender and frailty. There was a statistically significant relationship between frailty and older age, lower education level, lower economic level, co-morbidities, polypharmacy, diabetes, chronic obstructive pulmonary disease, gastric disease, arthritis, generalized pain, benign prostatic hyperplasia, urinary incontinence, auditory impairment, impaired oral care, caregiver burden, impaired cognitive function, depression, or a lack of social support (social isolation). Conclusions: It is believed that this study will contribute considerably to understanding the health status and needs of elderly adults in Turkey and the health problems of this population as well as to planning the development of public health and geriatric services based on regional needs. AN - WOS:000354416000001 AU - Cakmur, H. DA - Apr DO - 10.12659/msm.893400 N1 - Cakmur, Hulya PY - 2015 SN - 1643-3750 SP - 1232-1242 ST - Frailty Among Elderly Adults in a Rural Area of Turkey T2 - Medical Science Monitor TI - Frailty Among Elderly Adults in a Rural Area of Turkey UR - ://WOS:000354416000001 VL - 21 ID - 2238 ER - TY - JOUR AB - INTRODUCTION: Camine Con Gusto (CCG) is the Hispanic version of an evidence-based walking program for people with arthritis. This study examined CCG outcomes, feasibility, tolerability, safety, and acceptability and potential tailoring. METHOD: A pre and post 6-week evaluation was conducted in Hispanic people with arthritis. Outcomes included pain, stiffness, fatigue, functional capacity, helplessness, and self-efficacy. A formative evaluation with program participants and key stakeholders explored program tailoring. RESULTS: Participants' mean age was 46.9 years, 44.4% had a high school degree or less, 2.5% were born in United States, 60.1% spoke only Spanish, and 74.7% were female. Moderate effect sizes were found: 0.50 for pain, 0.75 for fatigue, 0.49 for stiffness, 0.33 for function, 0.26 for helplessness, and 0.24 for self-efficacy. There were 285 participants recruited with an 82% 6-week retention (feasibility), no adverse events were reported (safety), and 98% reported program satisfaction (acceptability). Recommended adaptations included simpler language, more pictures and content addressing nutrition and chronic conditions, shortened materials, and inclusion of motivational strategies. CONCLUSION: CCG showed improvement in outcomes in Hispanic individuals comparable to those noted in non-Hispanic White and Black individuals with arthritis. AD - University of North Carolina at Chapel Hill, NC, USA leigh_callahan@med.unc.edu. University of North Carolina at Chapel Hill, NC, USA. UNC Hospitals, Chapel Hill, NC, USA. AN - 27553228 AU - Callahan, L. F. AU - Rivadeneira, A. AU - Altpeter, M. AU - Vilen, L. AU - Cleveland, R. J. AU - Sepulveda, V. E. AU - Hackney, B. AU - Reuland, D. S. AU - Rojas, C. C2 - PMC5406131 C6 - NIHMS856328 DA - Sep DO - 10.1177/1540415316665202 DP - NLM ET - 2016/08/25 IS - 3 KW - Activities of Daily Living Adult Aged Aged, 80 and over Arthritis/complications/*therapy *Exercise Therapy *Fatigue Female *Hispanic Americans Humans Male Middle Aged *Pain Pain Management Program Evaluation *Range of Motion, Articular Self Efficacy United States *Walking Young Adult *chronic conditions *health disparities *health promotion *qualitative methods *quantitative methods of interest with respect to the research, authorship, and/or publication of this article. LA - eng N1 - 1938-8993 Callahan, Leigh F Rivadeneira, Alfredo Altpeter, Mary Vilen, Leigha Cleveland, Rebecca J Sepulveda, Victoria E Hackney, Betsy Reuland, Daniel S Rojas, Claudia TL1 TR001110/TR/NCATS NIH HHS/United States UL1 TR001111/TR/NCATS NIH HHS/United States UL1 TR002489/TR/NCATS NIH HHS/United States Evaluation Study Journal Article Hisp Health Care Int. 2016 Sep;14(3):132-40. doi: 10.1177/1540415316665202. Epub 2016 Aug 23. PY - 2016 SN - 1540-4153 (Print) 1540-4153 SP - 132-40 ST - Evaluation of the Arthritis Foundation's Camine Con Gusto Program for Hispanic Adults With Arthritis T2 - Hisp Health Care Int TI - Evaluation of the Arthritis Foundation's Camine Con Gusto Program for Hispanic Adults With Arthritis VL - 14 ID - 3883 ER - TY - JOUR AB - Background: Numerous studies have explored how patients and their caregivers cope with amyotrophic lateral sclerosis (ALS), but the literature completely lacks research on the psychological impact of the disease on patients' children. The aim of our study was to investigate the emotional and psychological impact of a parent with ALS on school-age children and adolescents in terms of problem behavior, adjustment, and personality characteristics. Methods: The study involved 23 children (mean age = 10.62 years, six females) with a parent suffering from ALS, and both their parents. Children were matched for age, gender, and birth-order with a control group of children with healthy parents. They were administered the Youth Self Report (YSR) questionnaire and the Rorschach Comprehensive System, and their healthy parent completed the Child Behavior Checklist (CBCL). Results: Findings clearly showed that, compared with controls, children with a parent who had ALS had several clinically significant adverse emotional and behavioral consequences, with emotional and behavioral problems, internalizing problems, anxiety and depressive symptoms. Children of a parent with ALS scored higher than controls for the Total Problems, Internalizing Problems, Anxious/Depressed and Withdrawn/Depressed scales in the YSR. A relevant percentage of children fell within the clinical range (42.9%) and borderline range (28.6%) for Internalizing Problems, The Rorschach CS confirmed the substantial impact of ALS in a parent on their offspring in terms of internalizing behavior and depression, with adjustment difficulties, psychological pain, and thought problems. Conclusion: Our findings indicate that school-aged children and adolescents with a parent who has ALS are vulnerable and carry a substantially higher risk of internalizing behavior, depressive symptoms, and reactive problems than children with healthy parents. Families affected may need support to cope with such an overwhelming disease. AN - WOS:000351099300001 AU - Calvo, V. AU - Bianco, F. AU - Benelli, E. AU - Sambin, M. AU - Monsurro, M. R. AU - Femiano, C. AU - Querin, G. AU - Soraru, G. AU - Palmieri, A. C7 - 288 DA - Mar DO - 10.3389/fpsyg.2015.00288 N1 - Calvo, Vincenzo Bianco, Francesca Benelli, Enrico Sambin, Marco Monsurro, Maria R. Femiano, Cinzia Querin, Giorgia Soraru, Gianni Palmieri, Arianna Calvo, Vincenzo/H-9090-2012; Benelli, Enrico/AAV-8667-2020; Soraro, Gianni/AAB-8891-2019 Calvo, Vincenzo/0000-0002-9828-0551; Benelli, Enrico/0000-0003-2549-2884; Soraru, Gianni/0000-0001-9691-6328; PALMIERI, Arianna/0000-0003-0453-001X PY - 2015 SN - 1664-1078 ST - Impact on children of a parent with ALS: a case-control study T2 - Frontiers in Psychology TI - Impact on children of a parent with ALS: a case-control study UR - ://WOS:000351099300001 VL - 6 ID - 2243 ER - TY - JOUR AB - Despite strong evidence that skin-to-skin contact and breast-feeding are effective pain-relieving interventions for infants undergoing painful procedures, they remain underutilized in clinical practice. Given the important contribution of parents, there is a need to find innovative ways to assist parents to become actively involved in their infant's care. We developed a YouTube video to disseminate evidence-based information on the effectiveness of skin-to-skin contact and breast-feeding for infant pain management. The 2-minute 39-second video launched on December 2, 2014, and was promoted through Web-based and in-person communication and YouTube advertisements. Data were collected using YouTube analytics and an online survey. Post-18 months from its launch, the video had a reach of 157 938 views from 154 countries, with most viewers watching an average of 73% of the video (1 minute 56 seconds). Parents (n = 32) and healthcare providers (n = 170) completed the survey. Overall, both reported that they liked the video, found it helpful, felt more confident, and were more likely to use skin-to-skin contact (16% and 12%) and breast-feeding (3% and 11%), respectively, during future painful procedures. Despite the high-viewing patterns, alternative methods should be considered to better evaluate the impact on practice change. AN - WOS:000415074200013 AU - Campbell-Yeo, M. AU - Dol, J. AU - Disher, T. AU - Benoit, B. AU - Chambers, C. T. AU - Sheffield, K. AU - Boates, T. AU - Harrison, D. AU - Hewitt, B. AU - Jangaard, K. AU - Stinson, J. AU - Taddio, A. AU - Parker, J. A. AU - Caddell, K. DA - Oct-Dec DO - 10.1097/jpn.0000000000000263 IS - 4 N1 - Campbell-Yeo, Marsha Dol, Justine Disher, Timothy Benoit, Britney Chambers, Christine T. Sheffield, Kaitlyn Boates, Talia Harrison, Denise Hewitt, Brenda Jangaard, Krista Stinson, Jennifer Taddio, Anna Parker, Jennifer A. Caddell, Kim Chambers, Christine T./ABA-9257-2020; Harrison, Denise/N-6684-2017 Chambers, Christine T./0000-0002-7138-916X; Harrison, Denise/0000-0001-7549-7742; Parker, Jennifer/0000-0001-9900-4703; Dol, Justine/0000-0002-8928-7647; Campbell-Yeo, Marsha/0000-0001-6645-2809 1550-5073 PY - 2017 SN - 0893-2190 SP - 341-349 ST - The Power of a Parent's Touch: Evaluation of Reach and Impact of a Targeted Evidence-Based YouTube Video T2 - Journal of Perinatal & Neonatal Nursing TI - The Power of a Parent's Touch: Evaluation of Reach and Impact of a Targeted Evidence-Based YouTube Video UR - ://WOS:000415074200013 VL - 31 ID - 2071 ER - TY - JOUR AB - Objectives: To determine the psychosocial correlates of recurrent pediatric pain and its relationship to health service use and medical presentations for "unexplained" symptoms in primary care. Study design: Children 4 to 15 years of age who complained frequently of aches and pains to parents were compared with those with infrequent or no pain on measures of demographics, psychopathology, school attendance and performance, perceived health, and service use. Univariate analysis was followed by logistic regression. Results: Children who complained often of aches and pains used more health services, had more psychosocial problems, missed more school, and did worse academically. After controlling for health service use and demographics, recurrent pain was significantly associated with negative parental perceptions of child health and the presence of internalizing psychiatric symptoms. Higher levels of ambulatory health service use were associated with negative perceptions of child health, recurrent pain, visits for "unexplained" symptoms, and internalizing psychiatric symptoms. Conclusions: Pediatric recurrent pain challenges traditional service delivery models characterized by segregated systems of care for physical and mental disorders. Longitudinal and psychobiological studies of the relationship between recurrent pain, internalizing psychopathology, and health beliefs are warranted to direct future treatment efforts. (J Pediatr 2002;141:76-83). AN - WOS:000176849800015 AU - Campo, J. V. AU - Comer, D. M. AU - Jansen-McWilliams, L. AU - Gardner, W. AU - Kelleher, K. J. DA - Jul DO - 10.1067/mpd.2002.125491 IS - 1 N1 - Campo, JV Comer, DM Jansen-McWilliams, L Gardner, W Kelleher, KJ Kelleher, Kelly/E-3361-2011 1097-6833 PY - 2002 SN - 0022-3476 SP - 76-83 ST - Recurrent pain, emotional distress, and health service use in childhood T2 - Journal of Pediatrics TI - Recurrent pain, emotional distress, and health service use in childhood UR - ://WOS:000176849800015 VL - 141 ID - 2828 ER - TY - JOUR AB - It is unknown whether children with functional gastrointestinal (GI) disorders identify specific foods that exacerbate their GI symptoms. The objectives of this study were to determine the perceived role of food on GI symptoms and to determine the impact of food-induced symptoms on quality of life (QOL) in children with functional GI disorders. Between August and November 2010, 25 children ages 11 to 17 years old with functional GI disorders, and a parent completed a food symptom association questionnaire and validated questionnaires assessing FGID symptoms and QOL. In addition, children completed a 24-hour food recall, participated in focus groups to identify problematic foods and any coping strategies, and discussed how their QOL was affected. Statistical analyses were conducted using chi 2, t test, Mann-Whitney U test, Wilcoxon signed rank, and Spearman's rho. Children identified a median of 11 (range=2 to 25) foods as exacerbating a GI symptom, with the most commonly identified foods being spicy foods, cow's milk, and pizza. Several coping strategies were identified, including consuming smaller portions, modifying foods, and avoiding a median of 8 (range=1 to 20) foods. Children reported that food-induced symptoms interfered with school performance, sports, and social activities. Although the parent's assessment of their child's QOL negatively correlated with the number of perceived symptom-inducing foods in their child, this relationship was not found in the children. Findings suggest that specific foods are perceived to exacerbate GI symptoms in children with functional GI disorders. In addition, despite use of several coping strategies, food-induced symptoms can adversely impact children's QOL in several important areas. AN - WOS:000332501100009 AU - Carlson, M. J. AU - Moore, C. E. AU - Tsai, C. M. AU - Shulman, R. J. AU - Chumpitazi, B. P. DA - Mar DO - 10.1016/j.jand.2013.10.013 IS - 3 N1 - Carlson, Michelle J. Moore, Carolyn E. Tsai, Cynthia M. Shulman, Robert J. Chumpitazi, Bruno P. 2212-2680 PY - 2014 SN - 2212-2672 SP - 403-413 ST - Child and Parent Perceived Food-Induced Gastrointestinal Symptoms and Quality of Life in Children with Functional Gastrointestinal Disorders T2 - Journal of the Academy of Nutrition and Dietetics TI - Child and Parent Perceived Food-Induced Gastrointestinal Symptoms and Quality of Life in Children with Functional Gastrointestinal Disorders UR - ://WOS:000332501100009 VL - 114 ID - 2315 ER - TY - JOUR AB - The purpose of the study was to determine the prevalence of recurrent headaches among schoolchildren in Goteborg and the relation of headache to school and family variables. A stratified sample of 1297 pupils was selected to be representative of the Goteborg population. Data were obtained by means of questionnaires. Twenty-six per cent had ''headache once a month or more'' and 6% had ''headache several times a week or daily'' (frequent headache). There was a gradual increase of headache with age. In the third grade there was a marked increase of frequent headache. In the highest school level (grades 7-9), girls had significantly more headache than boys. In the lower school level (grades 1-3), a greater number of pupils in the class increases the risk of frequent headache. Pupil in the intermediate school level (grades 4-6) reported more frequent headache in districts with high unemployment. It is concluded that headache among schoolchildren is a health problem which merits increased attention. AN - WOS:A1996UV57900012 AU - Carlsson, J. DA - Jun DO - 10.1111/j.1651-2227.1996.tb14128.x IS - 6 N1 - Carlsson, J PY - 1996 SN - 0803-5253 SP - 692-696 ST - Prevalence of headache in schoolchildren: Relation to family and school factors T2 - Acta Paediatrica TI - Prevalence of headache in schoolchildren: Relation to family and school factors UR - ://WOS:A1996UV57900012 VL - 85 ID - 2927 ER - TY - JOUR AB - OBJECTIVE. Increasing evidence confirms a strict relationship between mental disorders and physical health. Particularly, stressful life events and post-traumatic stress disorder (PTSD) have been closely correlated with various physical disorders and somatic symptoms, such as chronic pain, gastrointestinal disorders, and headaches. The aim of this study was to investigate the emergence of somatic symptoms in a sample of young adult survivors 21 months after exposure to the L'Aquila 2009 earthquake, with particular attention to PTSD and gender impact. METHODS. Four hundred and fifty high-school senior students (253 male and 197 female) exposed to the 2009 L'Aquila earthquake, 21 months earlier, were enrolled and evaluated by the Trauma and Loss Spectrum Self-Report (TALS-SR), for symptomatological PTSD, and the Mood Spectrum Self-Report-Lifetime Version (MOODS-SR) "rhythmicity and vegetative functions" domain, for somatic symptoms. RESULTS. Significantly higher rates of endorsement of the MOODS-SR somatic symptoms emerged in survivors with PTSD compared to those without. Females reported higher rates of endorsement of at least one MOODS-SR somatic symptom compared to males; however, a Decision Tree model and a two-way analysis of variance model confirmed a significant effect of PTSD only. A multivariate logistical regression showed a significant association between the presence of at least one MOOD-SR somatic symptom and re-experiencing and maladaptive coping TALS-SR domains. CONCLUSION. This study corroborates a relevant impact of symptomatological PTSD, across both the genders, on somatic symptoms occurring in young adults after months from exposure to a massive earthquake. AD - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. AN - 32248878 AU - Carmassi, C. AU - Dell'Oste, V. AU - Barberi, F. M. AU - Pedrinelli, V. AU - Cordone, A. AU - Cappelli, A. AU - Cremone, I. M. AU - Rossi, R. AU - Bertelloni, C. A. AU - Dell'Osso, L. DA - Apr 6 DO - 10.1017/s1092852920000097 DP - NLM ET - 2020/04/07 KW - Dsm-5 Post-traumatic stress disorder (PTSD) gastrointestinal diseases migraine natural disaster painful stimuli hypo- or hypersensitivity LA - eng N1 - Carmassi, Claudia Dell'Oste, Valerio Orcid: 0000-0003-0520-4785 Barberi, Filippo M Pedrinelli, Virginia Cordone, Annalisa Cappelli, Andrea Cremone, Ivan M Rossi, Rodolfo Bertelloni, Carlo A Dell'Osso, Liliana Journal Article United States CNS Spectr. 2020 Apr 6:1-7. doi: 10.1017/S1092852920000097. PY - 2020 SN - 1092-8529 (Print) 1092-8529 SP - 1-7 ST - Do somatic symptoms relate to PTSD and gender after earthquake exposure? A cross-sectional study on young adult survivors in Italy T2 - CNS Spectr TI - Do somatic symptoms relate to PTSD and gender after earthquake exposure? A cross-sectional study on young adult survivors in Italy ID - 4185 ER - TY - JOUR AB - Background: Increasing evidence indicates that survivors to traumatic events may show disruption of sleep pattern, eating and sexual behaviors, and somatic symptoms suggestive of alterations of biorhythmicity and vegetative functions. Therefore, the aim of this study was to investigate these possible alterations in a sample of survivors in the aftermath of earthquake exposure, with particular attention to gender differences and impact of post-traumatic stress disorder (PTSD). Methods: High school senior students, who had been exposed to the 2009 L'Aquila earthquake, were enrolled 21 months after the traumatic event and evaluated by the Trauma and Loss Spectrum Self-Report to investigate PTSD rates and by a domain of the Mood Spectrum Self-Report-Lifetime Version (MOODS-SR), to explore alterations in circadian/seasonal rhythms and vegetative functions. Results: The rates of endorsement of MOODS-SR rhythmicity and vegetative functions domain and subdomain scores were significantly higher in survivors with PTSD with respect to those without it. Among all earthquake survivors, women reported higher scores than men on the rhythmicity and vegetative functions domain and subdomain scores, except for the rhythmicity and sexual functions ones. Female survivors without PTSD showed significantly higher scores than men in the rhythmicity and vegetative functions total scores and the sleep and weight and appetite subdomains. Potentially traumatic events burden predicted rhythmicity and vegetative functions impairment, with a moderation effect of re-experiencing symptoms. Conclusions: We report impairments in rhythmicity, sleep, eating, and sexual and somatic health in survivors to a massive earthquake, particularly among subjects with PTSD and higher re-experiencing symptoms, with specific gender-related differences. Evaluating symptoms of impaired rhythmicity and vegetative functions seems essential for a more accurate assessment and clinical management of survivors to a mass trauma. AN - WOS:000593962700001 AU - Carmassi, C. AU - Dell'Oste, V. AU - Bertelloni, C. A. AU - Foghi, C. AU - Diadema, E. AU - Mucci, F. AU - Massimetti, G. AU - Rossi, A. AU - Dell'Osso, L. C7 - 492006 DA - Nov DO - 10.3389/fpsyt.2020.492006 N1 - Carmassi, Claudia Dell'Oste, Valerio Bertelloni, Carlo Antonio Foghi, Claudia Diadema, Elisa Mucci, Federico Massimetti, Gabriele Rossi, Alessandro Dell'Osso, Liliana Dell'Oste, Valerio/ABE-3538-2020 Dell'Oste, Valerio/0000-0003-0520-4785 PY - 2020 SN - 1664-0640 ST - Disrupted Rhythmicity and Vegetative Functions Relate to PTSD and Gender in Earthquake Survivors T2 - Frontiers in Psychiatry TI - Disrupted Rhythmicity and Vegetative Functions Relate to PTSD and Gender in Earthquake Survivors UR - ://WOS:000593962700001 VL - 11 ID - 1784 ER - TY - JOUR AB - Several epidemiological studies have shown the presence of comorbidity between various types of sleep disorders and different headache subtypes. Migraine without aura is a sensitive risk factor for disorders of initiating and maintaining sleep (odds ratio (OR) 8.2500), and chronic tension-type headache for sleep breathing disorders (OR 15.231), but headache disorder is a cumulative risk factor for disorders of excessive somnolence (OR 15.061). This result has not been reported in the clinical literature. AU - Carotenuto, Marco AU - Guidetti, Vincenzo AU - Ruju, Francesca AU - Galli, Federica AU - Tagliente, Francesca R. AU - Pascotto, Antonio DA - 2005/09// DO - 10.1007/s10194-005-0204-z DP - PubMed IS - 4 J2 - J Headache Pain KW - Child Child, Preschool Circadian Rhythm Comorbidity Headache Disorders Humans Risk Factors Sleep Stages Sleep Wake Disorders LA - eng PY - 2005 SN - 1129-2369 SP - 268-270 ST - Headache disorders as risk factors for sleep disturbances in school aged children T2 - The Journal of Headache and Pain TI - Headache disorders as risk factors for sleep disturbances in school aged children UR - http://www.ncbi.nlm.nih.gov/pubmed/16362683 VL - 6 ID - 130 ER - TY - JOUR AB - This review updates a similar paper published in the Journal of Family Therapy in 2001. It presents evidence from meta-analyses, systematic literature reviews and controlled trials for the effectiveness of systemic interventions for families of children and adolescents with various difficulties. In this context, systemic interventions include both family therapy and other family-based approaches such as parent training. The evidence supports the effectiveness of systemic interventions either alone or as part of multimodal programmes for sleep, feeding and attachment problems in infancy; child abuse and neglect; conduct problems (including childhood behavioural difficulties, ADHD, delinquency and drug abuse); emotional problems (including anxiety, depression, grief, bipolar disorder and suicidality); eating disorders (including anorexia, bulimia and obesity); and somatic problems (including enuresis, encopresis, recurrent abdominal pain, and poorly controlled asthma and diabetes). AN - WOS:000261979500002 AU - Carr, A. DA - Feb DO - 10.1111/j.1467-6427.2008.00451.x IS - 1 N1 - Carr, Alan Carr, Alan/0000-0003-4563-8852 1467-6427 PY - 2009 SN - 0163-4445 SP - 3-45 ST - The effectiveness of family therapy and systemic interventions for child-focused problems T2 - Journal of Family Therapy TI - The effectiveness of family therapy and systemic interventions for child-focused problems UR - ://WOS:000261979500002 VL - 31 ID - 2617 ER - TY - JOUR AB - Background: Little is known about lower back complaints in adolescent competitive alpine skiers. This study assessed their prevalence and severity (i.e., intensity and disability) with respect to sex, category, discipline preference, and training attributes. Methods: 188 competitive skiers aged 15 to 18 years volunteered in this study. Data collection included (i) questions on participants' demographics, sports exposure, discipline preferences, and other sports-related practices; (ii) the Nordic Musculoskeletal Questionnaire on lower back complaints; and (iii) the Graded Chronic Pain Scale. Results: As many as 80.3% and 50.0% of all skiers suffered from lower back complaints during the last 12 months and 7 days, respectively. A total of 50.7% reported their complaints to be attributable to slalom skiing, and 26% to giant slalom. The majority of complaints were classified as low intensity/low disability (Grade I, 57.4%) and high intensity/low disability complaints (Grade II, 21.8%). The Characteristic Pain Intensity was found to be significantly related to the skiers' years of sports participation, number of competitions/season, and number of skiing days/season. Conclusion: This study further supports the relatively high magnitudes of lower back-related pain in adolescent competitive alpine skiers, with a considerable amount of high intensity (but low disability) complaints, and training attributes being a key driver. AN - WOS:000588905700001 AU - Carraro, A. AU - Gnech, M. AU - Sarto, F. AU - Sarto, D. AU - Sporri, J. AU - Masiero, S. C7 - 7408 DA - Nov DO - 10.3390/app10217408 IS - 21 N1 - Carraro, Attilio Gnech, Martina Sarto, Fabio Sarto, Diego Spoerri, Joerg Masiero, Stefano Sarto, Fabio/AAP-7652-2021 Sarto, Fabio/0000-0001-8572-5147; Sporri, Jorg/0000-0002-0353-1021; Masiero, Stefano/0000-0002-0361-4898 2076-3417 PY - 2020 ST - Lower Back Complaints in Adolescent Competitive Alpine Skiers: A Cross-Sectional Study T2 - Applied Sciences-Basel TI - Lower Back Complaints in Adolescent Competitive Alpine Skiers: A Cross-Sectional Study UR - ://WOS:000588905700001 VL - 10 ID - 1790 ER - TY - JOUR AB - OBJECTIVES: To evaluate the lifetime prevalence of migraine and other headaches lasting 4 or more hours in a population-based study of older adults. BACKGROUND: Migraine and other headaches not fulfilling migraine criteria are common afflictions. Yet the health and social effects of these conditions have not been fully appreciated, particularly among older adults. METHODS: The study included 12 750 participants in the Atherosclerosis Risk in Communities (ARIC) Study from 4 US communities. Prevalence estimates of a lifetime history of migraine and other headaches lasting 4 or more hours were obtained for race and gender groups. A cross-sectional analysis was done to assess the relationship between headache type, by aura status, and various sociodemographic and health-related indices. RESULTS: Compared to education beyond high school, having completed less than 12 years of education was significantly associated with an increased occurrence of migraine with aura (prevalence odds ratio [POR], 1.47; 95% confidence interval [CI], 1.08 to 2.01). Family income less than $16 000, compared to family income of $75 000 or greater, was significantly associated with migraine with aura (POR, 1.68; 95% CI, 1.07 to 2.64), migraine without aura (POR, 1.56; 95% CI, 1.14 to 2.14), and other headaches with aura (POR, 1.89; 95% CI, 1.14 to 3.13). The prevalence odds ratio was higher in each headache category, particularly for those with an aura, for those with hypertension versus normotension and for those who perceived their general health as poor compared to those whose perception was excellent. CONCLUSIONS: A lifetime history of migraine with aura and other headaches with aura was more common among whites, women, and younger participants. Further investigation of headaches lasting 4 or more hours, particularly by aura status, is warranted. AD - Department of Epidemiology, University of North Carolina at Chapel Hill, USA. AN - 14979879 AU - Carson, A. P. AU - Rose, K. M. AU - Sanford, C. P. AU - Ephross, S. A. AU - Stang, P. E. AU - Hunt, K. J. AU - Brown, C. A. AU - Szklo, M. DA - Jan DO - 10.1111/j.1526-4610.2004.04005.x DP - NLM ET - 2004/02/26 IS - 1 KW - Aged Cohort Studies Female Headache/*epidemiology Humans Male Middle Aged Migraine Disorders/*epidemiology/etiology Prevalence Time Factors United States/epidemiology LA - eng N1 - Carson, April Perry Rose, Kathryn M Sanford, Catherine P Ephross, Sara A Stang, Paul E Hunt, Kelly J Brown, C Andrew Szklo, Moyses 5T32-HL-07055/HL/NHLBI NIH HHS/United States N01-HC-55018/HC/NHLBI NIH HHS/United States Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States Headache. 2004 Jan;44(1):20-8. doi: 10.1111/j.1526-4610.2004.04005.x. PY - 2004 SN - 0017-8748 (Print) 0017-8748 SP - 20-8 ST - Lifetime prevalence of migraine and other headaches lasting 4 or more hours: the Atherosclerosis Risk in Communities (ARIC) study T2 - Headache TI - Lifetime prevalence of migraine and other headaches lasting 4 or more hours: the Atherosclerosis Risk in Communities (ARIC) study VL - 44 ID - 3788 ER - TY - JOUR AB - OBJECTIVE: Our objective was to demonstrate that, despite recognition by both the gastroenterology and headache communities, abdominal migraine (AM) is an under-diagnosed cause of chronic, recurrent, abdominal pain in childhood in the USA. BACKGROUND: Chronic, recurrent abdominal pain occurs in 9-15% of all children and adolescents. After exclusion of anatomic, infectious, inflammatory, or other metabolic causes, "functional abdominal pain" is the most common diagnosis of chronic, idiopathic, abdominal pain in childhood. Functional abdominal pain is typically categorized into one, or a combination of, the following 4 groups: functional dyspepsia, irritable bowel syndrome, AM, or functional abdominal pain syndrome. International Classification of Headache Disorders--(ICHD-2) defines AM as an idiopathic disorder characterized by attacks of midline, moderate to severe abdominal pain lasting 1-72 hours with vasomotor symptoms, nausea and vomiting, and included AM among the "periodic syndromes of childhood that are precursors for migraine." Rome III Gastroenterology criteria (2006) separately established diagnostic criteria and confirmed AM as a well-defined cause of recurrent abdominal pain. METHODS: Following institutional review board approval, a retrospective chart review was conducted on patients referred to an academic pediatric gastroenterology practice with the clinical complaint of recurrent abdominal pain. ICHD-2 criteria were applied to identify the subset of children fulfilling criteria for AM. Demographics, diagnostic evaluation, treatment regimen and outcomes were collected. RESULTS: From an initial cohort of 600 children (ages 1-21 years; 59% females) with recurrent abdominal pain, 142 (24%) were excluded on the basis of their ultimate diagnosis. Of the 458 patients meeting inclusion criteria, 1824 total patient office visits were reviewed. Three hundred eighty-eight (84.6%) did not meet criteria for AM, 20 (4.4%) met ICHD-2 formal criteria for AM and another 50 (11%) had documentation lacking at least 1 criterion, but were otherwise consistent with AM (probable AM). During the observation period, no children seen in this gastroenterology practice had received a diagnosis of AM. CONCLUSION: Among children with chronic, idiopathic, recurrent abdominal pain, AM represents about 4-15%. Given the spectrum of treatment modalities now available for pediatric migraine, increased awareness of cardinal features of AM by pediatricians and pediatric gastroenterologists may result in improved diagnostic accuracy and early institution of both acute and preventative migraine-specific treatments. AD - Division of Pediatric Neurology, Children's Hospital of The King's Daughters, Eastern Virginia Medical Neurology School, Norfolk, VA 23509, USA. AN - 21395574 AU - Carson, L. AU - Lewis, D. AU - Tsou, M. AU - McGuire, E. AU - Surran, B. AU - Miller, C. AU - Vu, T. A. DA - May DO - 10.1111/j.1526-4610.2011.01855.x DP - NLM ET - 2011/03/15 IS - 5 KW - Abdominal Pain/classification/*complications/*epidemiology Adolescent Child Child, Preschool Female Humans Infant Male Migraine Disorders/classification/*complications/*epidemiology Prevalence United States/epidemiology Young Adult LA - eng N1 - 1526-4610 Carson, Laura Lewis, Donald Tsou, Marc McGuire, Erin Surran, Brooke Miller, Crystal Vu, Thuy-Anh Journal Article United States Headache. 2011 May;51(5):707-12. doi: 10.1111/j.1526-4610.2011.01855.x. Epub 2011 Mar 11. PY - 2011 SN - 0017-8748 SP - 707-12 ST - Abdominal migraine: an under-diagnosed cause of recurrent abdominal pain in children T2 - Headache TI - Abdominal migraine: an under-diagnosed cause of recurrent abdominal pain in children VL - 51 ID - 3109 ER - TY - JOUR AB - Chronic pain in children and adolescents is associated with major disruption to developmental experiences crucial to personal adjustment, quality of life, academic, vocational and social success. Caring for these patients involves understanding cognitive, affective, social and family dynamic factors associated with persistent pain syndromes. Evaluation and treatment necessitate a comprehensive multimodal approach including psychological and behavioral interventions that maximize return to more developmentally appropriate physical, academic and social activities. This article will provide an overview of major psychosocial factors impacting on pediatric pain and disability, propose an explanatory model for conceptualizing the development and maintenance of pain and functional disability in medically difficult-to-explain pain syndromes, and review representative evidence-based cognitive behavioral and systemic treatment approaches for improving functioning in this pediatric population. AN - WOS:000307334700001 AU - Carter, B. D. AU - Threlkeld, B. M. C7 - 15 DA - Jun DO - 10.1186/1546-0096-10-15 N1 - Carter, Bryan D. Threlkeld, Brooke M. 1546-0096 PY - 2012 ST - Psychosocial perspectives in the treatment of pediatric chronic pain T2 - Pediatric Rheumatology TI - Psychosocial perspectives in the treatment of pediatric chronic pain UR - ://WOS:000307334700001 VL - 10 ID - 2426 ER - TY - JOUR AB - Introduction: Although infrequently recorded in electronic health records (EHRs), measures of SES are essential to describe health inequalities and account for confounding in epidemiologic research. Medical Assistance (i.e., Medicaid) is often used as a surrogate for SES, but correspondence between conventional SES and Medical Assistance has been insufficiently studied. Methods: GeisingerClinic EHRdata from2001 to 2014 and a 2014 questionnaire were used to create six SES measures: EHR-derived Medical Assistance and proportion of time under observation on Medical Assistance; educational attainment, income, and marital status; and area-level poverty. Analyzed in 2016-2017, associations of SES measures with obesity, hypertension, type 2 diabetes, chronic rhinosinusitis, fatigue, and migraine headache were assessed using weighted age-and sex-adjusted logistic regression. Results: Among 5,550 participants (interquartile range, 39.6-57.5 years, 65.9% female), 83% never used Medical Assistance. All SES measures were correlated (Spearman's p= 0.4). Medical Assistance was significantly associated with all six health outcomes in adjusted models. For example, the OR for prevalent type 2 diabetes associated with Medical Assistance was 1.7 (95% CI = 1.3, 2.2); the OR for high school versus college graduates was 1.7 (95% CI = 1.2, 2.5). Medical Assistance was an imperfect proxy for SES: associations between conventional SES measures and health were attenuated <20% after adjustment for Medical Assistance. Conclusions: Because systematically collected SES measures are rarely available in EHRs and are unlikely to appear soon, researchers can use EHR-based Medical Assistance to describe inequalities. As SES has many domains, researchers who use Medical Assistance to evaluate the association of SES with health should expect substantial unmeasured confounding. (C) 2017 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved. AN - WOS:000425297700016 AU - Casey, J. A. AU - Pollak, J. AU - Glymour, M. M. AU - Mayeda, E. R. AU - Hirsch, A. G. AU - Schwartz, B. S. DA - Mar DO - 10.1016/j.amepre.2017.10.004 IS - 3 N1 - Casey, Joan A. Pollak, Jonathan Glymour, M. Maria Mayeda, Elizabeth R. Hirsch, Annemarie G. Schwartz, Brian S. Casey, Joan A./H-6405-2019 Casey, Joan A./0000-0002-9809-4695 1873-2607 PY - 2018 SN - 0749-3797 SP - 430-439 ST - Measures of SES for Electronic Health Record-based Research T2 - American Journal of Preventive Medicine TI - Measures of SES for Electronic Health Record-based Research UR - ://WOS:000425297700016 VL - 54 ID - 2030 ER - TY - JOUR AB - Children and adolescents spend most of their time at school. Therefore, teachers could be of help to improve the quality of life of students with chronic pain while they are at school. The aim of this study was to identify teachers' educational needs and resources to help improve the adjustment to and function in the school of students with chronic pain. A Delphi survey including two rounds was conducted. Overall, 49 needs were identified in the first round. They were related to education, training, organization/logistics, and communication with the family and the health care center. Among the most important needs, based on the importance given and consensus reached, were (1) having information about the most appropriate attitudes and responses to a student with chronic pain, (2) how to reduce absenteeism, (3) how to ease the return to school after a long absence due to his or her pain problem, and (4) how to establish effective communication with the family. The results of this study provide new important data on the educational needs and resources which teachers would like to have to help their students with chronic pain at school, which could be used to develop educative programs for teachers. AN - WOS:000645316300001 AU - Castarlenas, E. AU - Roy, R. AU - Salvat, I. AU - Monteso-Curto, P. AU - Miro, J. C7 - 4510 DA - Apr DO - 10.3390/su13084510 IS - 8 N1 - Castarlenas, Elena Roy, Ruben Salvat, Isabel Monteso-Curto, Pilar Miro, Jordi 2071-1050 PY - 2021 ST - Educational Needs and Resources for Teachers Working with Students with Chronic Pain: Results of a Delphi Study T2 - Sustainability TI - Educational Needs and Resources for Teachers Working with Students with Chronic Pain: Results of a Delphi Study UR - ://WOS:000645316300001 VL - 13 ID - 1745 ER - TY - JOUR AB - The purpose of this study is to determine whether there are some differences in the treatment responses to a multidisciplinary fibromyalgia (FM) treatment related with the baseline body mass index (BMI) of the participants. Inclusion criteria consisted of female sex, a diagnosis of FM (American College of Rheumatology criteria), age between 18 and 60 years, and between 3 and 8 years of schooling. Baseline BMI was determined, and patients were randomly assigned to one of the two treatment conditions: conventional pharmacologic treatment or multidisciplinary treatment. Outcome measures were pain intensity, functionality, catastrophizing, psychological distress, health-related quality of life, and sleep disturbances. One hundred thirty patients participated in the study. No statistical significant differences regarding pre-treatment outcomes were found among the different BMI subgroups, and between the two experimental conditions for each BMI category. General linear model analysis showed a significant interaction group treatment × time in pain intensity (p < .01), functionality (p < .0001), catastrophizing (p < .01), psychological distress (p < .0001), sleep index problems (p < .0001), and health-related quality of life (p < .05). No significant interactions were found in BMI × time, and in BMI × group treatment × time. There are not differences among normal weight, overweight and obese patients with FM regarding their response to a multidisciplinary treatment programme for FM which combines pharmacological treatment, education, physical therapy and cognitive behavioural therapy. AD - Pain Clinic, Hospital Universitari de Tarragona Joan XXIII, C/Doctor Mallafré Guasch, 4, 43007, Tarragona, Spain, antonicastel.hj23.ics@gencat.cat. AN - 25080875 AU - Castel, A. AU - Castro, S. AU - Fontova, R. AU - Poveda, M. J. AU - Cascón-Pereira, R. AU - Montull, S. AU - Padrol, A. AU - Qanneta, R. AU - Rull, M. DA - Feb DO - 10.1007/s00296-014-3096-x DP - NLM ET - 2014/08/02 IS - 2 KW - Adolescent Adult Analgesics/*therapeutic use Antidepressive Agents/*therapeutic use Body Mass Index Catastrophization/complications/psychology *Cognitive Behavioral Therapy Combined Modality Therapy Female Fibromyalgia/complications/psychology/*therapy Humans Hypnotics and Sedatives/*therapeutic use Middle Aged Obesity/*complications Overweight/complications Pain Measurement Patient Care Team *Physical Therapy Modalities Prognosis Quality of Life Sleep Wake Disorders/complications Stress, Psychological/complications/psychology Treatment Outcome Young Adult LA - eng N1 - 1437-160x Castel, Antoni Castro, Sonia Fontova, Ramon Poveda, Maria José Cascón-Pereira, Rosalia Montull, Salvador Padrol, Anna Qanneta, Rami Rull, Maria Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Germany Rheumatol Int. 2015 Feb;35(2):303-14. doi: 10.1007/s00296-014-3096-x. Epub 2014 Aug 1. PY - 2015 SN - 0172-8172 SP - 303-14 ST - Body mass index and response to a multidisciplinary treatment of fibromyalgia T2 - Rheumatol Int TI - Body mass index and response to a multidisciplinary treatment of fibromyalgia VL - 35 ID - 3561 ER - TY - JOUR AB - Although the etiology of chronic pain following trauma is not well understood, numerous retrospective studies have shown that a significant proportion of chronic pain patients have a history of traumatic injury. The present analysis examines the prevalence and early predictors of chronic pain in a cohort of prospectively followed severe lower extremity trauma patients. Chronic pain was measured using the Graded Chronic Pain Scale, which measures both pain severity and pain interference with activities. Severe lower extremity trauma patients report significantly higher levels of chronic pain than the general population (p<0.001). Their levels are comparable to primary care migraine headache and back pain populations. A number of early predictors of chronic pain were identified, including: having less than a high school education (p<0.01), having less than a college education (p<0.001), low self-efficacy for return to usual major activities (p<0.01), and high levels of average alcohol consumption at baseline (p<0.05). In addition, high reported pain intensity, high levels of sleep and rest dysfunction, and elevated levels of depression and anxiety at 3 months post-discharge were also strong predictors of chronic pain at seven years (p<0.001 for all three predictors). After adjusting for early pain intensity, patients treated with narcotic medication during the first 3 months post-discharge had lower levels of chronic pain at 84 months. It is possible that for patients within these high risk categories, early referral to pain management and/or psychologic intervention may reduce the likelihood or severity of chronic pain. AD - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC, USA. AN - 16781066 AU - Castillo, R. C. AU - MacKenzie, E. J. AU - Wegener, S. T. AU - Bosse, M. J. DA - Oct DO - 10.1016/j.pain.2006.04.020 DP - NLM ET - 2006/06/20 IS - 3 KW - Adult Aged Alcohol Drinking/epidemiology Amputation/psychology/*statistics & numerical data Anxiety/epidemiology Chronic Disease Depression/epidemiology Educational Status Follow-Up Studies Humans Leg Injuries/*epidemiology/surgery Limb Salvage/psychology/*statistics & numerical data Middle Aged Multivariate Analysis Narcotics/therapeutic use Pain/drug therapy/*epidemiology/psychology Predictive Value of Tests Prevalence Prospective Studies Risk Factors Self Efficacy Sleep Wake Disorders/epidemiology LA - eng N1 - 1872-6623 Castillo, Renan C MacKenzie, Ellen J Wegener, Stephen T Bosse, Michael J LEAP Study Group Journal Article United States Pain. 2006 Oct;124(3):321-329. doi: 10.1016/j.pain.2006.04.020. Epub 2006 Jun 15. PY - 2006 SN - 0304-3959 SP - 321-329 ST - Prevalence of chronic pain seven years following limb threatening lower extremity trauma T2 - Pain TI - Prevalence of chronic pain seven years following limb threatening lower extremity trauma VL - 124 ID - 3510 ER - TY - JOUR AB - Background: Abdominal pain related to irritable bowel syndrome (IBS) and functional abdominal pain (FAP) is frequent in children and can be of variable severity. Both IBS and FAP are associated with rectal hypersensitivity. We hypothesized that in children with IBS and FAP, the rectal sensory threshold for pain (RSTP) is associated with symptom severity. Paitents and Methods: A total of 47 patients (34 girls; median age, 14.2 years) with IBS (n = 29) and FAP (n = 18), according to the Rome 11 criteria, underwent a rectal barostat examination to determine their RSTR Gastrointestinal symptom severity was assessed by validated questionnaires. During the rectal barostat exam, symptoms were documented using a visual analog scale and by measuring the area coloured on a human body diagram corresponding to painful sensations. Results: The median RSTP was 16 mmHg and was similar in IBS and FAP patients. Eighty-three percent of the patients had rectal hypersensitivity (RSTP <= 30.8 mmHg, the 5th percentile of control children studied in our laboratory). Fifty-one percent and 36%, respectively, reported missing school and social activities at least once per week. Increased frequency of pain, missed days of school, missed social activities, and pain during the barostat examination were not associated with lower RSTP values in either the whole group or in the subset of children with rectal hypersensitivity. Conclusions: Rectal hypersensitivity is not proportional to the severity of symptoms in children with IBS and FAP, indicating that symptom severity is influenced by other factors in addition to visceral hypersensitivity. AN - WOS:000253551300006 AU - Castilloux, J. AU - Noble, A. AU - Faure, C. DA - Mar DO - 10.1097/MPG.0b013e31814b91e7 IS - 3 N1 - Castilloux, Julie Noble, Angela Faure, Christophe Faure, Christophe/AAD-8425-2019 Faure, Christophe/0000-0002-2998-8935 PY - 2008 SN - 0277-2116 SP - 272-278 ST - Is visceral hypersensitivity correlated with symptom severity in children with functional gastrointestinal disorders? T2 - Journal of Pediatric Gastroenterology and Nutrition TI - Is visceral hypersensitivity correlated with symptom severity in children with functional gastrointestinal disorders? UR - ://WOS:000253551300006 VL - 46 ID - 2660 ER - TY - JOUR AB - OBJECTIVE: To evaluate the frequency of anxiety and depression disorders in patients with chronic pain. METHOD: Patients receiving care at the pain clinic of the Federal University of Bahia between February 2003 and November 2006. The MINI PLUS--Mini International Neuropsychiatric Interview was used to evaluate the patients and establish psychiatric diagnoses. RESULTS: 400 patients were evaluated mean age was 45.6+/-11.37 years; 82.8% were female, 17.3% male; 48.5% were married; 55.1% were Catholics; and 40.5% had only high school education. Of these 29.9% reported intense pain and 70.8% reported suffering pain daily. The most frequent medical diagnosis was herniated disc (24.5%), and 48.5% of patients had been undergoing treatment at the pain clinic for less than 3 months. Comorbidities found were depressive episodes (42%), dysthymia (54%), social phobia (36.5%), agoraphobia (8.5%) and panic disorder (7.3%). CONCLUSION: Psychiatric comorbidities are prevalent in patients suffering chronic pain. AD - Pain Clinic, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, Brazil. marthamcastro@uol.com.br AN - 20069205 AU - Castro, M. AU - Kraychete, D. AU - Daltro, C. AU - Lopes, J. AU - Menezes, R. AU - Oliveira, I. DA - Dec DO - 10.1590/s0004-282x2009000600004 DP - NLM ET - 2010/01/14 IS - 4 KW - Anxiety Disorders/*etiology Chronic Disease Cross-Sectional Studies Depressive Disorder/*etiology Female Humans Male Middle Aged Pain/*psychology Socioeconomic Factors LA - eng N1 - 1678-4227 Castro, Martha Kraychete, Durval Daltro, Carla Lopes, Josiane Menezes, Rafael Oliveira, Irismar Journal Article Brazil Arq Neuropsiquiatr. 2009 Dec;67(4):982-5. doi: 10.1590/s0004-282x2009000600004. PY - 2009 SN - 0004-282x SP - 982-5 ST - Comorbid anxiety and depression disorders in patients with chronic pain T2 - Arq Neuropsiquiatr TI - Comorbid anxiety and depression disorders in patients with chronic pain VL - 67 ID - 3502 ER - TY - JOUR AB - Background: This study investigated the relationship between verbal aggression against school teachers and upper extremity (neck, shoulder, upper limb, and/or upper back) musculoskeletal pain. Methods: This was a cross-sectional study of 525 elementary school teachers from Jaboatao dos Guararapes, Northeast Brazil. Results: The prevalence of upper extremity musculoskeletal pain among teachers who reported verbal aggression in the past six months (67.7%) was higher than that among those who did not report verbal aggression (51.7%): (prevalence ratio = 1.21; 95% confidence interval = 1.04-1.40). The prevalence of upper extremity musculoskeletal pain was associated with verbal aggression, sex, and common mental disorders, controlled by skin color, age, monthly income, teachers' education, years working as a teacher, workload, and obesity. Furthermore, the measure of the association between verbal aggression and upper extremity musculoskeletal pain was modified by sex and common mental disorders, considered altogether. Teachers who suffered verbal aggression, of the feminine sex, and also having common mental disorders reported high prevalence (85.4%) of upper extremity musculoskeletal pain. Conclusion: The association between verbal violence in the school and complaints of upper extremity musculoskeletal pain was strong and modified by teachers' sex and common mental disorders. (C) 2020 Occupational Safety and Health Research Institute, Published by Elsevier Korea LLC. AN - WOS:000541503500010 AU - Ceballos, A. G. C. AU - Carvalho, F. M. DA - Jun DO - 10.1016/j.shaw.2020.02.003 IS - 2 N1 - Ceballos, Albanita G. C. Carvalho, Fernando M. ; Carvalho, Fernando/F-9811-2014 Ceballos, Albanita Gomes da Costa/0000-0002-8658-9981; Carvalho, Fernando/0000-0002-0969-0170 2093-7997 PY - 2020 SN - 2093-7911 SP - 187-192 ST - Verbal Aggression Against Teacher and Upper Extremity Musculoskeletal Pain T2 - Safety and Health at Work TI - Verbal Aggression Against Teacher and Upper Extremity Musculoskeletal Pain UR - ://WOS:000541503500010 VL - 11 ID - 1819 ER - TY - JOUR AB - OBJETIVES: To review the clinical, psychiatric, and social characteristics of complex regional pain syndrome in children and adolescents treated in the last 4 years at our pediatric pain clinic. MATERIAL AND METHODS: We analyzed the specialty of the initial treating physician, age, sex, initial diagnosis, pain intensity, degree of disability, fear of movement, clinical stage, history of trauma, time between onset and diagnosis, psychiatric illness, family support and behavior, chronic pain in near relatives, school grades and attendance, treatment given at the pediatric pain clinic, recurrences, and course of disease. RESULTS: The cases of 7 patients (4 female, 3 male) between the ages of 8 and 15 years were analyzed. Four had been referred by the child psychiatry department. The initial diagnosis was erroneous in all but 1 case. Pain intensity and associated disability were severe in 5 patients and 4 expressed intense fear of moving the limb. Five patients had initial stage I disease, 5 had a history of trauma, and 5 had been previously treated by immobilization of the limb and prescription of nonsteroidal anti-inflammatory drugs. The time between onset and diagnosis ranged from 2 to 18 months (mean [SD], 6.4 [3.5] months). In most cases psychiatric disease and concomitant social disability were present. Treatment prescribed at the pediatric pain clinic consisted of a combination of oral medication, psychologic and psychiatric counseling, and intensive physiotherapy for all but 2 children, who required regional nerve blocks. CONCLUSION: The clinical course was satisfactory for all but 1 patient, who developed severe disability. Complex regional pain syndrome affecting an upper limb is uncommon in children but not rare. AN - WOS:000449586700004 AU - Cebrian, J. AU - Sanchez, P. DO - 10.1016/s0034-9356(09)70358-5 IS - 3 N1 - Cebrian, J. Sanchez, P. 2340-3284 PY - 2009 SN - 0034-9356 SP - 163-169 ST - Pediatric complex regional pain syndrome affecting an upper limb: 7 cases and a brief review of the literature T2 - Revista Espanola De Anestesiologia Y Reanimacion TI - Pediatric complex regional pain syndrome affecting an upper limb: 7 cases and a brief review of the literature UR - ://WOS:000449586700004 VL - 56 ID - 2626 ER - TY - JOUR AB - Çekiç Ş, Özgür T, Karalı Y, Özkan T, Kılıç SŞ. Vedolizumab treatment in a patient with X-linked agammaglobulinemia, is it safe and efficient? Turk J Pediatr 2019; 61: 937-940. The loss of inflammatory regulation resulting from the absence of B-lymphocytes leads to a risk for autoimmune and autoinflammatory complications. There is no data on the use of Vedolizumab in patients with X-linked agammaglobulinemia (XLA) as well as children with another primary immunodeficiency (PID) diseases. A 4-year-old boy was admitted to our clinic with a history of recurrent respiratory tract infections. He was diagnosed with XLA based on extremely low immunoglobulins, very low level of B cells, genetic mutation of BTK gene, and family history. At the age of 8, he suffered from intermittent fever attacks, abdominal pain, weakness, oral aft, and weight loss. His clinical and laboratory features were consistent with inflammatory bowel disease. Histopathological examination of the biopsy material obtained from terminal ileum, colon and cecum showed Crohn`s disease. Initially, he was treated with prednisolone and infliximab. Because of the lack of response, infliximab treatment was switched to adalimumab. Terminal ileum was resected to relieve obstruction complication. Although he had been treated with adalimumab, a significant improvement was not observed. Vedolizumab (Entyvio™), a humanized monoclonal antibody α4β7 integrin-receptor antagonist, was commenced. After treatment with vedolizumab, his fever and abdominal pain attacks reduced, his total daily calorie intake increased and weight gain improved. He began to walk again and continued his school education properly. No side effects were observed in 18 months. This is the first immunocompromised child treated with vedolizumab. The symptoms of the patient receded and no side effect were seen during the treatment. AD - Divisions of Pediatric Immunology, Uludağ University Faculty of Medicine, Bursa, Turkey. Pediatric Gastroenterology, Department of Pediatrics, Uludağ University Faculty of Medicine, Bursa, Turkey. AN - 32134589 AU - Çekiç, Ş AU - Özgür, T. AU - Karalı, Y. AU - Özkan, T. AU - Kılıç, SŞ DO - 10.24953/turkjped.2019.06.016 DP - NLM ET - 2019/01/01 IS - 6 KW - Agammaglobulinaemia Tyrosine Kinase/genetics/metabolism Agammaglobulinemia/diagnosis/*drug therapy/genetics Antibodies, Monoclonal, Humanized/*therapeutic use Child, Preschool DNA/genetics DNA Mutational Analysis Gastrointestinal Agents/therapeutic use Genetic Diseases, X-Linked/diagnosis/*drug therapy/genetics Humans Magnetic Resonance Imaging Male Mutation *X linked agammaglobulinemia *adalimumab *crohn`s disease *vedolizumab LA - eng N1 - Çekiç, Şükrü Özgür, Taner Karalı, Yasin Özkan, Tanju Kılıç, Sara Şebnem Case Reports Turkey Turk J Pediatr. 2019;61(6):937-940. doi: 10.24953/turkjped.2019.06.016. PY - 2019 SN - 0041-4301 (Print) 0041-4301 SP - 937-940 ST - Vedolizumab treatment in a patient with X-linked agammaglobulinemia, is it safe and efficient? T2 - Turk J Pediatr TI - Vedolizumab treatment in a patient with X-linked agammaglobulinemia, is it safe and efficient? VL - 61 ID - 4103 ER - TY - JOUR AB - Introduction Somatic symptoms are frequently reported by children with significant impairment in functioning. Despite studies on adult populations that suggest somatic symptoms often co-occur with difficulties in identifying and describing feelings, little research has been done in childhood. This study aimed to investigate the prevalence and frequency of somatic symptoms as well as to investigate the functional impairment in children with high number of self reported somatic symptoms versus those with fewer somatic symptoms. Additionally the parental perception of their children's somatic symptoms and functioning was explored. Finally, we explored the direct and indirect effects of difficulties in identifying feelings in predicting somatic symptoms and functional disability among school-aged children. Methods 356 Italian school-aged children and their mothers participated in this study. Children (mean age = 11.43; SD = 2.41) completed the Children's Somatization Inventory (CSI-24) to assess somatic symptoms, the Functional Disability Inventory (FDI) to assess physical and psychosocial functioning and the Alexithymia Questionnaire for Children (AQC) to evaluate alexithymic features. Mothers completed the parental forms of the CSI and the FDI. Results Among children, 66.3% did not declare somatic symptoms and 33.7% reported one or more somatic symptoms in the last two weeks. A significant positive correlation emerged between children's and mothers' CSI total scores. Both children's and mothers' FDI total scores were significantly correlated with CSI scores. A significant correlation was observed between somatic symptoms and alexithymic features. Furthermore, the data showed that somatic symptoms mediated the relationship between difficulties in identifying feelings and functional impairment. Finally, it was showed that alexithymia facet of difficulty in identifying feelings contributed in large part to the prediction of the somatic symptomatology (b = 0.978, p < 0.001; R-2 = 0.164, F(5, 350) = 10.32, p < 0.001). Conclusions Findings from this study provide evidence that a higher frequency of somatic symptoms is associated with functional disabilities and alexithymic facets in school-aged children. AN - WOS:000393712500075 AU - Cerutti, R. AU - Spensieri, V. AU - Valastro, C. AU - Presaghi, F. AU - Canitano, R. AU - Guidetti, V. C7 - e0171867 DA - Feb DO - 10.1371/journal.pone.0171867 IS - 2 N1 - Cerutti, Rita Spensieri, Valentina Valastro, Carmela Presaghi, Fabio Canitano, Roberto Guidetti, Vincenzo Presaghi, Fabio/N-1590-2019 Presaghi, Fabio/0000-0001-7880-6715; SPENSIERI, VALENTINA/0000-0001-5413-3528 PY - 2017 SN - 1932-6203 ST - A comprehensive approach to understand somatic symptoms and their impact on emotional and psychosocial functioning in children T2 - Plos One TI - A comprehensive approach to understand somatic symptoms and their impact on emotional and psychosocial functioning in children UR - ://WOS:000393712500075 VL - 12 ID - 2108 ER - TY - JOUR AB - Objective Dysmenorrhea is the most important cause of chronic pelvic pain in women. Sometimes, dysmenorrhea can be severe enough, leading women to present to emergency departments. The aim of this study was to investigate factors affecting dysmenorrhea in female patients who presented to the emergency department of our hospital. Methods Female patients who presented to our emergency department with dysmenorrhea between January 2012 and January 2014 were included in the study. Patients' demographic and clinical data were filled in the Dysmenorrhea Data Form, which was designed by the researcher by screening the relevant literature. Patients' age, educational status, smoking status, age and regularity of menarche, sexual activity, and age of dysmenorrhea onset were recorded and analyzed. Results The mean age of the patients was 21.80 +/- 3.75 years. There was a significant correlation between the type of dysmenorrhea and sexual activity (p=0.001). There was a statistically significant difference between age at menarche and age of dysmenorrhea onset (p<0.001). Absenteeism was less common in patients with an age of dysmenorrhea onset of <12 years compared with the other age groups (p<0.05). Conclusions There was a significant correlation between age at menarche and age of dysmenorrhea onset. Data obtained in this study could be used in developing educational programs on dysmenorrhea for adolescents at the age of menarche. AN - WOS:000530287300017 AU - Cetin, A. C7 - e7977 DA - May DO - 10.7759/cureus.7977 IS - 5 N1 - Cetin, Ayse 2168-8184 PY - 2020 ST - Evaluation of Biological and Sociodemographic Factors Affecting Dysmenorrhea T2 - Cureus TI - Evaluation of Biological and Sociodemographic Factors Affecting Dysmenorrhea UR - ://WOS:000530287300017 VL - 12 ID - 1826 ER - TY - JOUR AB - At present, no consensus exists among clinical and academic experts regarding an appropriate placebo for randomized controlled trials (RCTs) of spinal manipulative therapy (SMT). Therefore, we investigated whether it was possible to conduct a chiropractic manual-therapy RCT with placebo. Seventy migraineurs were randomized to a single-blinded placebo-controlled clinical trial that consisted of 12 treatment sessions over 3 months. The participants were randomized to chiropractic SMT or placebo (sham manipulation). After each session, the participants were surveyed on whether they thought they had undergone active treatment ("yes" or "no") and how strongly they believed that active treatment was received (numeric rating scale 0-10). The outcome measures included the rate of successful blinding and the certitude of the participants' beliefs in both treatment groups. At each treatment session, more than 80% of the participants believed that they had undergone active treatment, regardless of group allocation. The odds ratio for believing that active treatment was received was >10 for all treatment sessions in both groups (all p < 0.001). The blinding was maintained throughout the RCT. Our results strongly demonstrate that it is possible to conduct a single-blinded manual-therapy RCT with placebo and to maintain the blinding throughout 12 treatment sessions given over 3 months. AD - 1] Head and Neck Research Group, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway [2] Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Oslo, Norway. 1] Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Oslo, Norway [2] HØKH, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway. AN - 26145718 AU - Chaibi, A. AU - Šaltytė Benth, J. AU - Bjørn Russell, M. C2 - PMC4491841 DA - Jul 6 DO - 10.1038/srep11774 DP - NLM ET - 2015/07/07 KW - Adolescent Adult Aged Female Headache Disorders/therapy Humans Male Manipulation, Chiropractic Middle Aged Musculoskeletal Manipulations Odds Ratio *Placebo Effect Treatment Outcome Validation Studies as Topic Young Adult LA - eng N1 - 2045-2322 Chaibi, Aleksander Šaltytė Benth, Jūratė Bjørn Russell, Michael Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't Sci Rep. 2015 Jul 6;5:11774. doi: 10.1038/srep11774. PY - 2015 SN - 2045-2322 SP - 11774 ST - Validation of Placebo in a Manual Therapy Randomized Controlled Trial T2 - Sci Rep TI - Validation of Placebo in a Manual Therapy Randomized Controlled Trial VL - 5 ID - 3655 ER - TY - JOUR AB - Objectives: To describe the demography, clinical characteristics, treatment, functional limitations and outcomes of patients referred to a paediatric multidisciplinary pain clinic. Design: Prospective data collection, descriptive study. Patients and setting: Tertiary referral centre pain clinic (Royal Children's Hospital, Melbourne) over two years (March 1998 - March 2000). Main outcome measures: Pain profile; functional disability (school absenteeism, sleep disturbance and inability to perform sport); treatments received; outcome. Results: 207 patients (mean age, 13.1 years; 73% females; 29% rural residents) were referred in the two years. Concomitant medical conditions were present in 106/207 (51 %) patients, the commonest being cerebral palsy or spasticity (22 patients) and malignancy (18). Complex regional pain syndrome was diagnosed in 44 patients. Functional disability due to pain included school absenteeism (95% of school attenders), sleep disruption (71% of all patients) and inability to perform sport (90% of those able to participate in sport previously). Of the 105 patients who missed five or more days of school because of pain, 93 attended school regularly after treatment. Sleep disturbance improved in 129/146 (88%) patients, and 129/147 (88%) resumed sporting activity after multidisciplinary intervention. Outcome was classified as good in 134 patients (65%), moderate in 32 (15%) and poor in 16 (8%). Conclusions: Chronic pain in children and adolescents often results in considerable functional disability. Functional improvement can be achieved using a multidisciplinary approach to pain management in children. AN - WOS:000172022700010 AU - Chalkiadis, G. A. DA - Nov DO - 10.5694/j.1326-5377.2001.tb143680.x IS - 9 N1 - Chalkiadis, GA 1326-5377 PY - 2001 SN - 0025-729X SP - 476-+ ST - Management of chronic pain in children T2 - Medical Journal of Australia TI - Management of chronic pain in children UR - ://WOS:000172022700010 VL - 175 ID - 2844 ER - TY - JOUR AB - BACKGROUND: Patients with fibromyalgia report persistent widespread pain, fatigue, and substantial functional limitations, which may lead to high health resource use (HRU) and lost productivity. Previous analyses of the U.S. population have not examined the direct and indirect costs of fibromyalgia by severity level. OBJECTIVES: To assess (a) HRU, direct and indirect costs associated with fibromyalgia in routine clinical practice in the United States using a patient-centric approach, and (b) the relationship of fibromyalgia severity level to HRU and costs. METHODS: This study recruited a nonprobability convenience sample of 203 subjects aged 18 through 65 years between August 2008 and February 2009 from 20 U.S. community-based physician offices. Subjects had a prior diagnosis of fibromyalgia by a rheumatologist, neurologist, or pain specialist; received treatment at the enrolling physician's practice for at least 3 months; experienced widespread pain for at least 3 months; and experienced pain in the previous 24 hours. Subjects completed a 106-item patient questionnaire that included 5 validated health-related quality-of-life instruments and study-specific questions about demographics; clinical history; overall health; treatment satisfaction; and impact of fibromyalgia on cognitive function, daily activities, and employment status. Subjects also self-reported hours of unpaid informal caregiver time because of inability to perform daily activities (e.g., housework, child care), out-of-pocket expenses for medical and nonmedical services, and lost productivity related to fibromyalgia for the previous 4 weeks. The 20-item Fibromyalgia Impact Questionnaire total score was used to stratify subjects into fibromyalgia severity groups (0 to less than 39 = mild, 39 to less than 59 = moderate, 59 to 100 = severe). Staff at each site recorded clinical characteristics, HRU, and medication use attributable to fibromyalgia on a paper clinical case report form (CRF) based on a 3-month retrospective medical chart review. Unit costs for 2009 were assigned to the 3-month HRU data reported on the CRF and 4-week subject-reported lost productivity. Costs were then annualized and reported in the following categories: direct medical, direct nonmedical, and indirect. Differences across severity levels were evaluated using the Kruskal-Wallis test (continuous measures) and Pearson chi-square or Fisher's exact tests (categorical measures) at the 0.05 alpha level. RESULTS: Of the 203 subjects, 21(10.3%) had mild, 49 (24.1%) had moderate, and 133 (65.5%) had severe fibromyalgia. For subjects with mild, moderate, and severe fibromyalgia, respectively, the number of fibromyalgia-related medications (3-month means: 1.8, 2.3, and 2.8, P = 0.011) and office visits to health care providers (3-month means: 2.7, 5.2, and 6.9, P < 0.001) significantly differed across severity levels. Across severity levels, total medical and nonmedical out-of-pocket costs also differed (P = 0.025). Mean [median] 3-month total direct costs (including payer costs for HRU and out-of-pocket costs for medical and nonmedical services) were $1,213 [$1,150], $1,415 [$1,215], and $2,329 [$1,760] for subjects with mild, moderate, and severe fibromyalgia, respectively (P = 0.002); and mean [median] 3-month indirect costs (including subject-reported absenteeism, unemployment, disability, and the estimated value of unpaid informal care) were $1,341 [$0], $5,139 [$1,680], and $8,285 [$7,030] (P < 0.001). Mean total indirect costs accounted for 52.5%, 78.4%, and 78.1% of mean total costs for subjects with mild, moderate, and severe fibromyalgia, respectively. CONCLUSIONS: Direct and indirect costs related to fibromyalgia are higher among subjects with worse fibromyalgia severity. Indirect costs account for a majority of fibromyalgia-related costs at all fibromyalgia severity levels. J Manag Care Pharm. 2012;18(6):415-26 Copyright (C) 2012, Academy of Managed Care Pharmacy. All rights reserved. AN - WOS:000307318600001 AU - Chandran, A. AU - Schaefer, C. AU - Ryan, K. AU - Baik, R. AU - McNett, M. AU - Zlateva, G. DA - Jul-Aug DO - 10.18553/jmcp.2012.18.6.415 IS - 6 N1 - Chandran, Arthi Schaefer, Caroline Ryan, Kellie Baik, Rebecca McNett, Michael Zlateva, Gergana Chandran, Arthi/0000-0002-5291-2103 PY - 2012 SN - 1083-4087 SP - 415-426 ST - The Comparative Economic Burden of Mild, Moderate, and Severe Fibromyalgia: Results from a Retrospective Chart Review and Cross-Sectional Survey of Working-Age U.S. Adults T2 - Journal of Managed Care Pharmacy TI - The Comparative Economic Burden of Mild, Moderate, and Severe Fibromyalgia: Results from a Retrospective Chart Review and Cross-Sectional Survey of Working-Age U.S. Adults UR - ://WOS:000307318600001 VL - 18 ID - 2423 ER - TY - JOUR AB - OBJECTIVE: To estimate the frequency of chronic joint pain after infection with chikungunya virus in a Latin American cohort. METHODS: A cross-sectional follow-up of a prospective cohort of 500 patients from the Atlántico Department, Colombia who were clinically diagnosed as having chikungunya virus during the 2014-2015 epidemic was conducted. Baseline symptoms and follow-up symptoms at 20 months were evaluated in serologically confirmed cases. RESULTS: Among the 500 patients enrolled, 485 had serologically confirmed chikungunya virus and reported joint pain status. Patients were predominantly adults (mean ± SD age 49 ± 16 years) and female, had an education level of high school or less, and were of Mestizo ethnicity. The most commonly affected joints were the small joints, including the wrists, ankles, and fingers. The initial virus symptoms lasted a median of 4 days (interquartile range [IQR] 3-8 days). Sixteen percent of the participants reported missing school or work (median 4 days [IQR 2-7 days]). After 20 months, one-fourth of the participants had persistent joint pain. A multivariable analysis indicated that significant predictors of persistent joint pain included college graduate status, initial symptoms of headache or knee pain, missed work, normal activities affected, ≥4 days of initial symptoms, and ≥4 weeks of initial joint pain. CONCLUSION: This is the first report to describe the frequency of chikungunya virus-related arthritis in the Americas after a 20-month follow-up. The high frequency of chronic disease highlights the need for the development of prevention and treatment methods. AD - The George Washington University, Washington, DC. Allied Research Society, Barranquilla, Colombia. Universidad El Bosque, Bogotá, Colombia. University of Nebraska Medical Center, Omaha. US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland. University of California at San Diego. AN - 29266783 AU - Chang, A. Y. AU - Encinales, L. AU - Porras, A. AU - Pacheco, N. AU - Reid, S. P. AU - Martins, K. A. O. AU - Pacheco, S. AU - Bravo, E. AU - Navarno, M. AU - Rico Mendoza, A. AU - Amdur, R. AU - Kamalapathy, P. AU - Firestein, G. S. AU - Bethony, J. M. AU - Simon, G. L. C2 - PMC7928267 C6 - NIHMS921079 DA - Apr DO - 10.1002/art.40384 DP - NLM ET - 2017/12/22 IS - 4 KW - Adult Arthralgia/*epidemiology/virology Arthritis, Infectious/*epidemiology/virology Chikungunya Fever/*complications/virology *Chikungunya virus Chronic Pain/*epidemiology/virology Colombia/epidemiology Cross-Sectional Studies Female Follow-Up Studies Humans Male Middle Aged Prospective Studies LA - eng N1 - 2326-5205 Chang, Aileen Y Orcid: 0000-0001-7410-9867 Encinales, Liliana Porras, Alexandra Pacheco, Nelly Reid, St Patrick Martins, Karen A O Pacheco, Shamila Bravo, Eyda Navarno, Marianda Rico Mendoza, Alejandro Amdur, Richard Kamalapathy, Priyanka Firestein, Gary S Bethony, Jeffrey M Simon, Gary L KL2 TR001877/TR/NCATS NIH HHS/United States UL1 TR001876/TR/NCATS NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Arthritis Rheumatol. 2018 Apr;70(4):578-584. doi: 10.1002/art.40384. Epub 2018 Mar 2. PY - 2018 SN - 2326-5191 (Print) 2326-5191 SP - 578-584 ST - Frequency of Chronic Joint Pain Following Chikungunya Virus Infection: A Colombian Cohort Study T2 - Arthritis Rheumatol TI - Frequency of Chronic Joint Pain Following Chikungunya Virus Infection: A Colombian Cohort Study VL - 70 ID - 3762 ER - TY - JOUR AB - Objective: To investigate whether the clinical history, particularly of the adolescence period, contains markers of deeply infiltrating endometriosis (DIE). Design: Cross-sectional study. Setting: Universitary tertiary referral center. Patient(s): Two hundred twenty-nine patients operated on for endometriosis. Endometriotic lesions were histologically confirmed as non-DIE (superficial peritoneal endometriosis and/or ovarian endometriomas) (n = 131) or DIE (n = 98). Intervention(s): Surgical excision of endometriotic lesions with pathological analysis of each specimens. Main Outcome Measure(s): Epidemiological data, pelvic pain scores, family history of endometriosis, absenteeism from school during menstruation, oral contraceptive (OC) pill use. Result(s): Patients with DIE had significantly more positive family history of endometriosis (odds ratio [OR] 3.2; 95% confidence interval [CI]: 1.2-8.8) and more absenteeism from school during menstruation (OR 1.7; 95% CI: 1-3). The OC pill use for treating severe primary dysmenorrhea was more frequent in patients with DIE (OR 4.5; 95% CI: 1.9-10.4). Duration of OC pill use for severe primary dysmenorrhea was longer in patients with DIE (8.4 +/- 4.7 years vs. 5.1 +/- 3.8 years). There was a higher incidence of OC pill use for severe primary dysmenorrhea before 18 years of age in patients with DIE (OR 4.2; 95% CI: 1.8-10.0). Conclusion(s): The knowledge of adolescent period history can identify markers that are associated with DIE in patients undergoing surgery for endometriosis. (Fertil Steril (R) 2011; 95: 877-81. (C) 2011 by American Society for Reproductive Medicine.) AN - WOS:000287480300008 AU - Chapron, C. AU - Lafay-Pillet, M. C. AU - Monceau, E. AU - Borghese, B. AU - Ngo, C. AU - Souza, C. AU - de Ziegler, D. DA - Mar DO - 10.1016/j.fertnstert.2010.10.027 IS - 3 N1 - Chapron, Charles Lafay-Pillet, Marie-Christine Monceau, Elise Borghese, Bruno Ngo, Charlotte Souza, Carlos de Ziegler, Dominique de Souza, Carlos Augusto Bastos/G-4872-2014; Chapron, Charles/O-8567-2017 Ngo, Charlotte/0000-0002-6225-8803 1556-5653 PY - 2011 SN - 0015-0282 SP - 877-881 ST - Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis T2 - Fertility and Sterility TI - Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis UR - ://WOS:000287480300008 VL - 95 ID - 2507 ER - TY - JOUR AB - PURPOSE: This was the open-label study to evaluate the potential benefit of Pinus radiata bark extract and vitamin C as a treatment for migraine. METHODS: Fifty outpatients with chronic migraine refractory to at least two prophylactic medications were treated with an antioxidant formulation of 1200 mg Pinus radiata bark extract and 150 mg vitamin C daily for 3 months. Patients completed migraine disability assessment (MIDAS) questionnaires at the beginning and end of the study to assess migraine impact on work, school, domestic and social activities over the three months prior to enrollment and the three month treatment period. Patients continued existing pharmacologic medications during the study. Patients who were responders were assessed for migraine impact using MIDAS questionnaires every 3 months for 12 months. RESULTS: Twenty nine patients (58%) showed improvement in MIDAS score, number of headache days and headache severity score over the 3 months of treatment. Mean MIDAS score significantly improved from 30.3 days at baseline to 14.4 days; mean number of headache days significantly reduced from 47.9 days at baseline to 25.9 days, and mean headache severity reduced from 8.1 out of 10 to 5.6 after 3 months therapy. The responders who continuously took Pinus radiata bark extract and vitamin C combination for 12 months experienced ongoing migraine relief with more than 50% reduction of frequency and severity of headaches. CONCLUSION: These data suggest that the antioxidant therapy used in this study may be beneficial in the treatment of migraine possibly reducing headache frequency and severity. AD - Department of Neurology, Kaiser Permanente Medical Center, Anaheim, CA, USA. siri.chayasirisobhon@kp.org AN - 23479241 AU - Chayasirisobhon, S. DA - Mar DP - NLM ET - 2013/03/13 IS - 1 KW - Adolescent Adult Aged Ascorbic Acid/*administration & dosage Disability Evaluation Drug Therapy, Combination Female Humans Longitudinal Studies Male Middle Aged Migraine Disorders/*prevention & control Phytotherapy/*methods Pinus/*chemistry Plant Preparations/*therapeutic use Prospective Studies Severity of Illness Index Surveys and Questionnaires Time Factors Young Adult LA - eng N1 - Chayasirisobhon, Sirichai Journal Article China (Republic : 1949- ) Acta Neurol Taiwan. 2013 Mar;22(1):13-21. PY - 2013 SN - 1028-768X (Print) 1028-768x SP - 13-21 ST - Efficacy of Pinus radiata bark extract and vitamin C combination product as a prophylactic therapy for recalcitrant migraine and long-term results T2 - Acta Neurol Taiwan TI - Efficacy of Pinus radiata bark extract and vitamin C combination product as a prophylactic therapy for recalcitrant migraine and long-term results VL - 22 ID - 3852 ER - TY - JOUR AB - OBJECTIVE: To identify the cause of an outbreak of foot pain syndrome among students from a senior high school in Foshan. METHODS: We defined a suspect case as onset of foot pain/numbness with unknown reason among students and teachers in a school of Foshan city, from February 10 to March 16, 2014. A suspect case was noticed as having both food pain and numbness. All the cases were searched through reviewing medical records in the nearby hospitals and school's clinic, also the records of absenteeism in school. Clinical information was collected from all the students, using a standardized questionnaire. Daily temperature was collected from all the students, between January 1 and March 31, 2014. A 1 : 2 individual matched case-control study was conducted to identify related risk factors on this epidemic. We interviewed all the cases and controls on their diet, physical activities and measures used for warming. RESULTS: A total of 407 case-students were identified, with an attack rate (AR) as 26.5%. The AR was 37.3% in girls, compared to 12.9% in boys. The difference was statistically significant (χ² = 115.1, P < 0.01). Boarding students had a higher AR (31.8%) than the commuting students (16.2%). The difference was statistically significant (χ² = 43.2, P < 0.01). In girls, boarding students had higher AR (46.1%) than those commuting students (18.5%). The difference was statistically significant (χ² = 61.4, P < 0.01). No statistically significant difference was found between boarding or commuting students in boys. Outdoor temperature was coming down from 23 °C on February 6 to 6 °C on February 13, but gradually rose to 23 °C on February 28. There was a positive relationship (r = 0.65, P = 0.002) noticed between daily maximum temperature and the number of cases during February 13-28. Results from this case-control study showed that factors as lacking physical activities (OR = 2.8, 95% CI: 1.5-5.6), feeling cold in bed (OR = 3.0, 95% CI: 1.3-7.0) and having experienced similar symptoms (OR = 3.4, 95% CI: 1.1-11.0) could increase the risk of this disease. CONCLUSION: This outbreak was possibly caused by the abrupt fluctuation of temperature within a short period. AD - Chancheng Center for Disease Control and Prevention of Guangdong Province, Foshan 528000, China. Xuanwu Hospital, Capital Medical University. Institute of Skin Diseases, China Academy of Medical Sciences. Peking University Sixth Hospital. Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention; Institute for Communicable Disease Control and Prevention, Shijiazhuang Center for Disease Control and Prevention. National Health and Family Planning Commission. Chancheng Prefectural Experimental High School. Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention; Email: cfetpzlj@126.com. Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention. AN - 26564639 AU - Chen, F. AU - Shao, Z. AU - Liang, C. AU - Wang, X. AU - Yang, X. AU - Yao, G. AU - Zhao, S. AU - Wang, L. AU - Ou, Z. AU - Zhang, L. AU - Luo, H. DA - Jun DP - NLM ET - 2015/11/14 IS - 6 KW - Case-Control Studies China/epidemiology *Disease Outbreaks Female Foot Diseases/*epidemiology Humans Male Pain/*epidemiology Residence Characteristics/statistics & numerical data Risk Factors *Schools Students/*statistics & numerical data Surveys and Questionnaires Syndrome Temperature Time Factors Transportation/statistics & numerical data LA - chi N1 - Chen, Fengling Shao, Zhaoming Liang, Chaobin Wang, Xiangbo Yang, Xueyuan Yao, Guizhong Zhao, Shuqing Wang, Lili Ou, Zhongying Zhang, Lijie Luo, Huiming Journal Article China Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Jun;36(6):629-33. PY - 2015 SN - 0254-6450 (Print) 0254-6450 SP - 629-33 ST - [An outbreak of foot pain syndrome among students from a senior high school in Foshan, Guangdong province, 2014] T2 - Zhonghua Liu Xing Bing Xue Za Zhi TI - [An outbreak of foot pain syndrome among students from a senior high school in Foshan, Guangdong province, 2014] VL - 36 ID - 3910 ER - TY - CHAP A2 - Stephanidis, C. AB - There is a growing concern about students' psychological health at school with mounting pressure as students approach middle school or college age. In light of the fact that the current means of psychological intervention are basically manual intervention, this research explored the possibility of using technology to assist psychological intervention. An emotion management system is thus implemented to provide facial emotion cognitive service and video diary function. In addition to the advantage of keeping a normal diary, students benefit by regulating their emotion when they are recording videos. Teachers can keep track of students' emotion states so that they can provide corresponding psychological supports when students showed signs of mental disorders. We performed a small-scale pilot study at a local school with satisfying results. AN - WOS:000553811700051 AU - Chen, J. AU - Qiu, X. Y. AU - Winoto, P. DO - 10.1007/978-3-319-92279-9_51 N1 - Chen, Jie Qiu, Xiaoyang Winoto, Pinata 20th International Conference on Human-Computer Interaction (HCI International) Jul 15-20, 2018 Las Vegas, NV 1865-0929 PY - 2018 SN - 978-3-319-92279-9; 978-3-319-92278-2 SP - 380-386 ST - An Emotion Management System via Face Tracking, Data Management, and Visualization T2 - Hci International 2018 - Posters' Extended Abstracts, Pt Ii T3 - Communications in Computer and Information Science TI - An Emotion Management System via Face Tracking, Data Management, and Visualization UR - ://WOS:000553811700051 VL - 851 ID - 2057 ER - TY - JOUR AB - Experimental ooplasmic transplantation from donor to recipient oocyte took place between 1996 and 2001 at Saint Barnabas Medical Center, USA. Indication for 33 patients was repeated implantation failure. Thirteen couples had 17 babies. One patient delivered twins from mixed ooplasmic and donor egg embryos. A limited survey-based follow-up study on the children is reported: 12 out of 13 parents completed a questionnaire on pregnancy, birth, health, academic performance and disclosure. Parents of a quadruplet did not participate. Prenatal development and delivery were uneventful. School grades ranged from good to excellent. Children were of good health. Body mass index (BMI) was normal in 12 out of 13 children. One child had chronic migraine headaches, two mild asthma, three minor vision and three minor skin problems. One boy from a boy/girl twin was diagnosed with borderline pervasive developmental disorder - not otherwise specified at age 18 months, but with no later symptoms. One couple disclosed the use of egg donor to their child. One reported intention to disclose; six were undecided and four reported they would not disclose. This limited follow-up strategy presents a high risk of bias. Parents may not assent to standardized clinical analysis owing to lack of disclosure to their children. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd. AN - WOS:000393169500009 AU - Chen, S. H. AU - Pascale, C. AU - Jackson, M. AU - Szvetecz, M. A. AU - Cohen, J. DA - Dec DO - 10.1016/j.rbmo.2016.10.003 IS - 6 N1 - Chen, Serena H. Pascale, Claudia Jackson, Maria Szvetecz, Mary Ann Cohen, Jacques 1472-6491 PY - 2016 SN - 1472-6483 SP - 737-744 ST - A limited survey-based uncontrolled follow-up study of children born after ooplasmic transplantation in a single centre T2 - Reproductive Biomedicine Online TI - A limited survey-based uncontrolled follow-up study of children born after ooplasmic transplantation in a single centre UR - ://WOS:000393169500009 VL - 33 ID - 2127 ER - TY - JOUR AB - This study used data from Waves I and II of the Taiwan Educational Panel Survey (TEPS) to explore the potential short-term and long-term effects of parental illness and health condition on children's behavioral and educational functioning. A sample of 11,018 junior high school students and their parents and teachers in Taiwan were included in this present study. The results supported previous work that parental illness may place children at slight risk for poor psychosocial adjustment and behavioral problems. Parental illness was associated with lower adaptive skills and more behavioral problems in children. Children of ill parents showed resilience in their educational functioning in the event of parental illness as children's academic achievement and learning skills were not related to parental illness/health condition. AN - WOS:000334291100006 AU - Chen, Y. C. DA - May DO - 10.1177/0193945913509899 IS - 5 N1 - Chen, Yung-Chi Chen, Cliff Yung-Chi/K-4115-2016 Chen, Cliff Yung-Chi/0000-0001-8659-5305 1552-8456 PY - 2014 SN - 0193-9459 SP - 664-684 ST - Exploration of the Short-Term and Long-Term Effects of Parental Illness on Children's Educational and Behavioral Functioning Using a Large Taiwanese Sample T2 - Western Journal of Nursing Research TI - Exploration of the Short-Term and Long-Term Effects of Parental Illness on Children's Educational and Behavioral Functioning Using a Large Taiwanese Sample UR - ://WOS:000334291100006 VL - 36 ID - 2309 ER - TY - JOUR AB - This study tested a theoretical relationship between trauma exposure, youth coping strategies and peer, family and community level factors on psychological distress and well-being among 399 trauma-affected youth in the Democratic Republic of Congo. Structural equation modeling (SEM) was used to analyze paths and to assess differences in relationships by gender. Psychological distress was measured by self-reports of internalizing problems (depression and anxiety), externalizing problems (aggression and behavioral problems) and somatic complaints (pain without medical cause). Self-reports of happiness, hope and self-esteem were measures of well-being. Findings from this study suggest gender differences in how individual coping strategies and external factors explain mental health resilience in trauma-affected youth. Problem-focused coping strategies were associated with higher psychological distress in both boys and girls. Use of avoidance was associated with better well-being in girls and boys and use of faith-based coping strategies was associated with better well-being in boys. Use of both problem-focused and emotion-focused coping strategies (coping flexibility) resulted in lower psychological distress in boys and girls. The home environment including closeness to family, caregiver post traumatic stress disorder and violence in the home was associated with psychological distress and well-being. Having close peer relationships, village safety and enrollment in school benefited well-being. Results from these SEM of resilience suggest that interventions should (1) work to build the coping repertoire of youth, (2) support reduction in psychological distress through improved family relationships and caregiver mental health and (3) target improved well-being through support of positive peer and community relationships and school enrollment. AN - WOS:000408063300011 AU - Cherewick, M. AU - Tol, W. AU - Burnham, G. AU - Doocy, S. AU - Glass, N. DO - 10.1080/21642850.2016.1228458 IS - 1 N1 - Cherewick, Megan Tol, Wietse Burnham, Gilbert Doocy, Shannon Glass, Nancy PY - 2016 SN - 2164-2850 SP - 155-174 ST - A structural equation model of conflict-affected youth coping and resilience T2 - Health Psychology and Behavioral Medicine TI - A structural equation model of conflict-affected youth coping and resilience UR - ://WOS:000408063300011 VL - 4 ID - 2189 ER - TY - JOUR AB - Background. Tooth decay is the most common paediatric disease and there is a serious paediatric tooth decay epidemic in Alaska Native communities. When untreated, tooth decay can lead to pain, infection, systemic health problems, hospitalisations and in rare cases death, as well as school absenteeism, poor grades and low quality-of-life. The extent to which population-based oral health interventions have been conducted in Alaska Native paediatric populations is unknown. Objective. To conduct a systematic review of oral health interventions aimed at Alaska Native children below age 18 and to present a case study and conceptual model on multilevel intervention strategies aimed at reducing sugar-sweetened beverage (SSB) intake among Alaska Native children. Design. Based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Statement, the terms "Alaska Native", "children" and "oral health" were used to search Medline, Embase, Web of Science, GoogleScholar and health foundation websites (1970-2012) for relevant clinical trials and evaluation studies. Results. Eighty-five studies were found in Medline, Embase and Web of Science databases and there were 663 hits in GoogleScholar. A total of 9 publications were included in the qualitative review. These publications describe 3 interventions that focused on: reducing paediatric tooth decay by educating families and communities; providing dental chemotherapeutics to pregnant women; and training mid-level dental care providers. While these approaches have the potential to improve the oral health of Alaska Native children, there are unique challenges regarding intervention acceptability, reach and sustainability. A case study and conceptual model are presented on multilevel strategies to reduce SSB intake among Alaska Native children. Conclusions. Few oral health interventions have been tested within Alaska Native communities. Community-centred multilevel interventions are promising approaches to improve the oral and systemic health of Alaska Native children. Future investigators should evaluate the feasibility of implementing multilevel interventions and policies within Alaska Native communities as a way to reduce children's health disparities. AN - WOS:000325721900222 AU - Chi, D. L. C7 - 21066 DO - 10.3402/ijch.v72i0.21066 N1 - Chi, Donald L. 2242-3982 1 PY - 2013 SN - 1239-9736 SP - 633-645 ST - Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case study on multilevel strategies to reduce sugar-sweetened beverage intake T2 - International Journal of Circumpolar Health TI - Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case study on multilevel strategies to reduce sugar-sweetened beverage intake UR - ://WOS:000325721900222 VL - 72 ID - 2392 ER - TY - JOUR AB - Purpose. The purpose of this study was to examine the influencing factors of postoperative pain among children undergoing elective surgery. Design and Methods. A survey was conducted in 2011 with a convenience sample of 66 children, 6 to 14 years old, in a tertiary hospital in Singapore. Results. Children experienced moderate preoperative anxiety and postoperative pain. Gender, preoperative anxiety, and negative emotional behaviors were significant influencing factors for postoperative pain. Boys reported less postoperative pain than girls. Practice Implications. Effective strategies for assessing and managing children's preoperative anxiety are needed to achieve an optimal postoperative pain management outcome. AN - WOS:000321296100009 AU - Chieng, Y. J. S. AU - Chan, W. C. S. AU - Liam, J. L. W. AU - Klainin-Yobas, P. AU - Wang, W. R. AU - He, H. G. DA - Jul DO - 10.1111/jspn.12030 IS - 3 N1 - Chieng, Ying Jia Shermin Chan, Wai Chi Sally Liam, Joanne Li Wee Klainin-Yobas, Piyanee Wang, Wenru He, Hong-Gu Wang, Wenru/N-1523-2019; Chan, Sally Wai Chi/ABB-8520-2020 Chan, Sally Wai Chi/0000-0001-5484-4645; Wang, Wenru/0000-0002-0265-8215 PY - 2013 SN - 1539-0136 SP - 243-252 ST - Exploring influencing factors of postoperative pain in school-age children undergoing elective surgery T2 - Journal for Specialists in Pediatric Nursing TI - Exploring influencing factors of postoperative pain in school-age children undergoing elective surgery UR - ://WOS:000321296100009 VL - 18 ID - 2362 ER - TY - JOUR AB - Children aged 6 to 11 who have been injured in a traffic accident were observed over a one year period, in parallel with a control group of children. More than one-third of the injured children had been hospitalized (for periods ranging anywhere between 1 and 47 days). One year later, one injured child out of ten was still suffering from pain, and/or still being treated for injuries resulting from the accident. Many other factors were linked to the initial overall level of severity of the injuries, contrary to that of pain, such as the rate and duration of hospitalization, the duration of care provided, the number of medical consultations, and absenteeism from school. Children who had been injured in a road traffic accident were found to be more anxious and nervous, in general, as well as having a high prevalence of sleeping disorders in comparison to the children in the control group. AD - Unité Mixte de Recherche (Inrets-Université Claude Bernard Lyon1-InVS) Epidémiologique et de Surveillance Transport Travail Environnement, Inrets Institut national de recherche sur les transports et leur sécurité, Bron. AN - 16676711 AU - Chiron, M. AU - Charnay, P. AU - Martin, J. L. AU - Vergnes, I. DA - Mar DO - 10.3917/spub.061.0023 DP - NLM ET - 2006/05/09 IS - 1 KW - *Accidents, Traffic Age Factors Anxiety/etiology Bicycling/injuries Child Female Follow-Up Studies France Hospitalization Humans Length of Stay Male Mental Disorders/*etiology Pain/etiology Pain Management Personality Risk Factors Sex Factors Sleep Wake Disorders/*etiology Socioeconomic Factors Surveys and Questionnaires Time Factors Wounds and Injuries/*complications/psychology/therapy LA - fre N1 - Chiron, M Charnay, P Martin, J L Vergnes, I Comparative Study English Abstract Journal Article France Sante Publique. 2006 Mar;18(1):23-39. doi: 10.3917/spub.061.0023. OP - Consequénces des accidents de la circulation chez les enfants: suivi pendant un an dans le département du Rhône. PY - 2006 SN - 0995-3914 (Print) 0995-3914 SP - 23-39 ST - [Consequences for children involved in a road traffic accident: one year of observation and follow-up in the Rhone county] T2 - Sante Publique TI - [Consequences for children involved in a road traffic accident: one year of observation and follow-up in the Rhone county] VL - 18 ID - 3865 ER - TY - JOUR AB - OBJECTIVE: Recurrent abdominal pain (RAP) of childhood is a common problem encountered by clinicians. The aim of this study was to systematically review published literature about the prevalence, incidence, natural history, and co-morbid conditions of childhood RAP in western countries. METHODS: A computer-assisted search of MEDLINE, EMBASE, and Current Contents/Science Edition databases was performed. Study selection criteria included: (1) United States and European population and school-based samples of children; (2) diagnostic criteria of RAP; and (3) published in full manuscript form in English. Data were extracted, tabulated, and presented in descriptive form. RESULT: The prevalence of RAP ranged from 0.3 to 19% (median 8.4; IQR 2.3-14.7). Published studies in children demonstrate a higher prevalence of RAP in females, with the highest prevalence of symptoms between 4 and 6 yr and early adolescence. Identified studies demonstrated associations between RAP and the child's familial and socioeconomic environment. In addition, childhood RAP was reported to be associated with psychological co-morbidity in childhood and adulthood. Population/school-based studies have not, however, established the incidence of this disorder, what features predict long-standing symptoms, or whether RAP is a risk factor for adult functional bowel disorders. CONCLUSION: RAP is a common complaint of childhood with associated familial, psychological, and co-morbid conditions. Epidemiologic studies of RAP in children may offer information on the evolution of functional bowel disorders through the lifespan. AD - Motility Unit, Division of Gastroenterology and Nutrition, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. AN - 16086724 AU - Chitkara, D. K. AU - Rawat, D. J. AU - Talley, N. J. DA - Aug DO - 10.1111/j.1572-0241.2005.41893.x DP - NLM ET - 2005/08/10 IS - 8 KW - Abdominal Pain/*epidemiology/etiology Child Chronic Disease Europe/epidemiology Humans Incidence Prevalence Recurrence United States/epidemiology LA - eng N1 - Chitkara, Denesh K Rawat, David J Talley, Nicholas J Journal Article Research Support, Non-U.S. Gov't Review Systematic Review United States Am J Gastroenterol. 2005 Aug;100(8):1868-75. doi: 10.1111/j.1572-0241.2005.41893.x. PY - 2005 SN - 0002-9270 (Print) 0002-9270 SP - 1868-75 ST - The epidemiology of childhood recurrent abdominal pain in Western countries: a systematic review T2 - Am J Gastroenterol TI - The epidemiology of childhood recurrent abdominal pain in Western countries: a systematic review VL - 100 ID - 3189 ER - TY - JOUR AB - BACKGROUND: Until recently, non-specific low back pain (NSLBP) in adolescents was considered a rare phenomenon unlike in adults. The last two decades has shown an increasing amount of research highlighting the prevalence in this age group. Recent studies estimate lifetime prevalence at 7%-80%, point prevalence at 10%-15%, and prevalence of recurrent NSLBP at 13%-36%. In Zimbabwe, there is dearth of literature on the magnitude of the problem in adolescents. Therefore, the aims of the study were to determine the prevalence (lifetime, point, recurrent) and the nature of recurrent NSLBP reported by adolescents in secondary schools. METHODS: A cross-sectional study was conducted using a questionnaire. A cluster sample of 544 adolescents (age 13-19 years) randomly derived from government schools participated in the study. Lifetime prevalence, point prevalence and prevalence of recurrent NSLBP were presented as percentages of the total population. Exact 95% confidence intervals were given. Chi-square test was used to evaluate the effect of gender and age on prevalence. RESULTS: The students' response rate was 97.8%. The lifetime prevalence was 42.9% [95% confidence interval = 40.8-44.6] with no significant difference between sexes [χ2 (1) =0.006, p=0.94]. However, NSLBP peaked earlier in female students (13.9 years) than in male students (15 years) [t (226) = 4.21, p<0.001]. About 10% of the adolescents reported having an episode of NSLBP on the day of the survey. However, female students (14.2%) were more affected on the day [χ2 (1) =11.2, p<0.001]. Twenty-nine percent of the adolescents experienced recurrent NSLBP with 78% experiencing at least three episodes in the last 12 months. On average, recurrent NSLBP reported was mild in intensity (4.8 ± 1.9) on the visual analogue scale (VAS) and short in duration. Recurrent NSLBP was associated with sciatica in 20.9% of adolescents. CONCLUSIONS: NSLBP is a common occurrence among Zimbabwean adolescents in secondary schools. It increases with chronological age and is recurrent in the minority of adolescents. Although much of the symptomatology may be considered benign, the existence of recurrent NSLBP in adolescents before their work-life begins should be a concern to health professionals, teachers and parents. AD - Department of Rehabilitation, University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe. matthewchiwaridzo@yahoo.co.uk. AN - 25406690 AU - Chiwaridzo, M. AU - Naidoo, N. C2 - PMC4246475 DA - Nov 19 DO - 10.1186/1471-2474-15-381 DP - NLM ET - 2014/11/20 KW - Adolescent Cross-Sectional Studies Female Humans Low Back Pain/*diagnosis/*epidemiology Male *Pain Measurement/methods Prevalence Recurrence Young Adult Zimbabwe/epidemiology LA - eng N1 - 1471-2474 Chiwaridzo, Matthew Naidoo, Nirmala Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't BMC Musculoskelet Disord. 2014 Nov 19;15:381. doi: 10.1186/1471-2474-15-381. PY - 2014 SN - 1471-2474 SP - 381 ST - Prevalence and associated characteristics of recurrent non-specific low back pain in Zimbabwean adolescents: a cross-sectional study T2 - BMC Musculoskelet Disord TI - Prevalence and associated characteristics of recurrent non-specific low back pain in Zimbabwean adolescents: a cross-sectional study VL - 15 ID - 3565 ER - TY - JOUR AB - PURPOSE: The purpose of the study was to investigate the consequences of recurrent non-specific low back pain in Zimbabwean adolescents. Recurrent non-specific low back pain is a common cause of adult disability in low-income countries. However, its impact in adolescents has been a matter of debate in the literature. METHODS: A survey was conducted using a cluster sample of 544 school children between the ages of 13 and 19 years. The school children were randomly selected from government-administered secondary schools in Harare, Zimbabwe. RESULTS: Parental and students' response rate were 90.3 and 97.8 %, respectively. Almost a third (28.8 %) of school children reported recurrent symptoms (CI 27.8-31.6). However, the majority (84 %) of these cases were unknown to parents. Twenty-seven percent reported having sought medical treatment. On the nine-item Hanover Low Back Pain Disability Questionnaire, 71.2 % of school children had at least one activity of daily living compromised by recurrent NSLBP, especially sports participation. However, severe disability was reported in 28 % of the adolescents. Health-care seeking behaviour was not associated with the level of disability [χ (2)(1) = 0.36, p = 0.55]. CONCLUSION: Although most parents are unaware, recurrent NSLBP is common in Zimbabwean school children. However, treatment is rarely sought for the symptoms. A preponderance of adolescents with recurrent NSLBP experiences some degree of functional consequences, although severe disability is rare. There is need to raise awareness of the condition in schools and to parents. Spinal health educational programmes may need to be implemented to avert the functional consequences. Further studies are needed in the future to investigate the coping strategies for pain in adolescents. AD - Department of Rehabilitation, College of Health Sciences, University of Zimbabwe, Avondale, P.O Box A178, Harare, Zimbabwe. CHWMAT001@myuct.ac.za. Department of Health and Rehabilitation Sciences, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa. niri.naidoo@uct.ac.za. AN - 26148568 AU - Chiwaridzo, M. AU - Naidoo, N. DA - Feb DO - 10.1007/s00586-015-4105-9 DP - NLM ET - 2015/07/08 IS - 2 KW - Activities of Daily Living Adolescent Age Distribution Cross-Sectional Studies Disability Evaluation Female Health Surveys Humans Low Back Pain/*diagnosis/epidemiology/physiopathology/rehabilitation Male Pain Measurement/methods Patient Acceptance of Health Care/*statistics & numerical data Prevalence Recurrence Young Adult Zimbabwe/epidemiology Adolescents Functional consequences Hanover Low Back Pain Disability Questionnaire Health-care seeking behaviour Recurrent non-specific low back pain LA - eng N1 - 1432-0932 Chiwaridzo, Matthew Naidoo, Nirmala Journal Article Germany Eur Spine J. 2016 Feb;25(2):643-50. doi: 10.1007/s00586-015-4105-9. Epub 2015 Jul 7. PY - 2016 SN - 0940-6719 SP - 643-50 ST - Functional consequences and health-care seeking behaviour for recurrent non-specific low back pain in Zimbabwean adolescents: a cross-sectional study T2 - Eur Spine J TI - Functional consequences and health-care seeking behaviour for recurrent non-specific low back pain in Zimbabwean adolescents: a cross-sectional study VL - 25 ID - 3616 ER - TY - JOUR AB - Age at menarche and menstrual symptoms were recorded in a sample of Thai schoolgirls in Bangkok. Using a random sampling proportional to size from this target population, structured questionnaires were offered to a sample of 15998 girls of grades 4-12. Fifty-six per cent of the study population was menarcheal during the time of study. Average mean ages by recalling age at menarche and by probit analysis were 12.51 +/- 1.17 and 12.35 +/- 1.41 years, respectively. The onset of menstruation occurred most frequently in April and October. Abdominal pain was the most common symptom during the menstrual period. Acne, malaise and back pain were other common complaints. AN - WOS:A1997XU50900005 AU - Chompootaweep, S. AU - Tankeyoon, M. AU - Poomsuwan, P. AU - Yamarat, K. AU - Dusitsin, N. DA - Sep-Oct DO - 10.1080/03014469700005192 IS - 5 N1 - Chompootaweep, S Tankeyoon, M Poomsuwan, P Yamarat, K Dusitsin, N PY - 1997 SN - 0301-4460 SP - 427-433 ST - Age at menarche in Thai girls T2 - Annals of Human Biology TI - Age at menarche in Thai girls UR - ://WOS:A1997XU50900005 VL - 24 ID - 2904 ER - TY - JOUR AB - BACKGROUND: The number of fluctuations of skin conductance per second (NFSC) has been shown to correlate with induced pain and self-report pain scales. This study aimed to evaluate the validity and feasibility of NFSC as an objective measurement of nociception intensity in school-aged children after surgery. METHODS: After approval by the research ethics board and obtaining consent, 100 subjects participated in this prospective observational study. Preoperatively, NFSC was measured for 60 s at rest and during response to a self-report pain scale (numeric rating scale [NRS], Faces Pain Scale-Revised) and anxiety scoring (NRS). Postoperative measurements were repeated every 10 min for 30 min or until NRS pain score was or= 7) with 56.3% sensitivity (95% CI = 37.7-73.6%) and 78.4% specificity (95% CI = 71.7-84.1%). The area under receiver operator characteristic curve for NFSC was 69.1%. CONCLUSIONS: NFSC measurement is feasible in a perioperative setting but was not specific for postoperative pain intensity and was unable to identify analgesia requirements when compared with self-report measures. AU - Choo, Eugene K. AU - Magruder, William AU - Montgomery, Carolyne J. AU - Lim, Joanne AU - Brant, Rollin AU - Ansermino, J. Mark DA - 2010/07// DO - 10.1097/ALN.0b013e3181de6ce9 DP - PubMed IS - 1 J2 - Anesthesiology KW - Adolescent Area Under Curve Child Feasibility Studies Female Galvanic Skin Response Humans Male Pain Measurement Pain, Postoperative Prospective Studies Reproducibility of Results ROC Curve Self Disclosure Sensitivity and Specificity Severity of Illness Index LA - eng PY - 2010 SN - 1528-1175 SP - 175-182 ST - Skin conductance fluctuations correlate poorly with postoperative self-report pain measures in school-aged children T2 - Anesthesiology TI - Skin conductance fluctuations correlate poorly with postoperative self-report pain measures in school-aged children UR - http://www.ncbi.nlm.nih.gov/pubmed/20526184 VL - 113 ID - 107 ER - TY - BOOK A2 - McClain, B. C. A2 - Suresh, S. AN - WOS:000291622000003 AU - Chorney, J. M. AU - Crofton, K. AU - McClain, B. C. DO - 10.1007/978-1-4419-0350-1_3 N1 - Chorney, Jill MacLaren Crofton, Kathryn McClain, Brenda C. PY - 2011 SN - 978-1-4419-0349-5 SP - 27-44 ST - Theories on Common Adolescent Pain Syndromes T2 - Handbook of Pediatric Chronic Pain: Current Science and Integrative Practice TI - Theories on Common Adolescent Pain Syndromes UR - ://WOS:000291622000003 ID - 2514 ER - TY - JOUR AB - Background: Nearly 20% of children and adolescents have pain with disability 1 year after surgery, and they experience poor sleep, school absence, and decreased activities. Negative clinical, psychological, and developmental effects include greater pain medication use, longer recovery, and fear of future medical care. Research has found psychological and family influences (i.e., child and parental anxiety) on pediatric chronic postsurgical pain (CPSP), but a better understanding of the role of perioperative anxiety and its related states in predicting pediatric postsurgical pain is needed. The poor understanding of the causes of child CPSP can lead to misdiagnosis and inadequate treatment, with significant short- and long-term effects. Objectives: The aim of this review was to summarize the literature on children's perioperative anxiety and parental anxiety in relation to acute postsurgical pain, CPSP, and pain trajectories. We also examined other related psychological factors (i.e., anxiety sensitivity, catastrophizing, pain anxiety, and fear of pain) in relation to pediatric acute and chronic postsurgical pain. Lastly, we discuss the interventions that may be effective in reducing children's and parents' preoperative anxiety. Conclusions: Our findings may improve the understanding of the causes of CPSP and highlight the gaps in research and need for further study. AN - WOS:000605584200005 AU - Chow, C. H. T. AU - Schmidt, L. A. AU - Buckley, D. N. DA - Dec DO - 10.1080/24740527.2020.1847600 IS - 4 N1 - Chow, Cheryl H. T. Schmidt, Louis A. Buckley, D. Norman Si PY - 2020 SN - 2474-0527 SP - 26-36 ST - The role of anxiety and related states in pediatric postsurgical pain T2 - Canadian Journal of Pain-Revue Canadienne De La Douleur TI - The role of anxiety and related states in pediatric postsurgical pain UR - ://WOS:000605584200005 VL - 4 ID - 1778 ER - TY - JOUR AB - Objectives: The aim of the present study was to determine whether concomitant gastroparesis and biliary dyskinesia (BD) occur in children, and if so, to determine whether concomitant gastroparesis affects clinical outcome in children with BD. Methods: We conducted a retrospective chart review of children with BD (ejection fraction <35% on cholescintigraphy, with no other metabolic or structural cause) who completed a solid-phase gastric emptying scintigraphy scan within 12 months of abnormal cholescintigraphy. Children were classified into 1 of 4 clinical outcome groups (excellent, good, fair, poor). Results: Thirty-five children with a mean follow-up time of 23.1 +/- 17.3 (standard deviation) months were included. Twenty (57%) children were identified as having concomitant gastroparesis (GP) with BD. Children with concomitant GP were more likely to have a poor clinical outcome compared with those with BD alone (P < 0.005). In children undergoing cholecystectomy, those with concomitant GP were more likely to have a fair or poor clinical outcome compared with those with BD alone (P < 0.01). Factors predicting a more favorable clinical outcome were having BD alone and not having limitations in activity (eg, school absences) at the time of presentation. Conclusions: Concomitant GP may occur in children with functional gallbladder disorders. Concomitant GP may negatively affect clinical outcome in children with BD. AN - WOS:000304115900015 AU - Chumpitazi, B. P. AU - Malowitz, S. M. AU - Moore, W. AU - Gopalakrishna, G. S. AU - Shulman, R. J. DA - Jun DO - 10.1097/MPG.0b013e3182455cf9 IS - 6 N1 - Chumpitazi, Bruno P. Malowitz, Stanton M. Moore, Warren Gopalakrishna, G. S. Shulman, Robert J. 1536-4801 PY - 2012 SN - 0277-2116 SP - 776-779 ST - Concomitant Gastroparesis Negatively Affects Children With Functional Gallbladder Disease T2 - Journal of Pediatric Gastroenterology and Nutrition TI - Concomitant Gastroparesis Negatively Affects Children With Functional Gallbladder Disease UR - ://WOS:000304115900015 VL - 54 ID - 2434 ER - TY - JOUR AB - BACKGROUND: Professional American-style football players are among the largest athletes across contemporary sporting disciplines. Weight gain during football participation is common, but the health implications of this early-life weight gain remain incompletely understood. We sought to define weight trajectories of former professional American-style football athletes and to establish their relationship with 5 common health afflictions (cardiovascular disease, cardiometabolic disease, neurocognitive impairment, sleep apnea, and chronic pain). METHODS: A health survey was distributed to former National Football League (NFL) players. Former players reported body weight at 4 time points (high school, college, professional, and time of survey response) as well as maximal retirement weight. Logistic regression was used to assess associations between weight gain during football participation and health affliction. RESULTS: In this cohort of former NFL players (n = 3,506, age 53 +/- 14 years), mean weight increase from high school to time of survey response was 40 +/- 36 pounds, with the majority of weight gain occurring during periods of football participation (high-school-to-college and college-to-professional). The prevalence of health afflictions ranged from 9% (cardiovascular disease) to 28% (chronic pain). Weight gain during football participation was independently associated with risk of multiple later-life health afflictions in models adjusted for football exposure, lifestyle variables, and post-career weight gain. CONCLUSIONS: Early-life weight gain among American-style football athletes is common and is associated with risk of adverse health profiles during later-life. These findings establish football-associated weight gain as a key predictor of post-career health and raise important questions about the central role of targeted weight gain in this population. (C) 2018 Elsevier Inc. All rights reserved. AN - WOS:000451731500028 AU - Churchill, T. W. AU - Krishnan, S. AU - Weisskopf, M. AU - Yates, B. A. AU - Speizer, F. E. AU - Kim, J. H. AU - Nadler, L. E. AU - Pascual-Leone, A. AU - Zafonte, R. AU - Baggish, A. L. DA - Dec DO - 10.1016/j.amjmed.2018.07.042 IS - 12 N1 - Churchill, Timothy W. Krishnan, Supriya Weisskopf, Marc Yates, Brandon A. Speizer, Frank E. Kim, Jonathan H. Nadler, Lee E. Pascual-Leone, Alvaro Zafonte, Ross Baggish, Aaron L. Pascual-Leone, Alvaro/AAC-5101-2019 Pascual-Leone, Alvaro/0000-0001-8975-0382 1555-7162 PY - 2018 SN - 0002-9343 SP - 1491-1498 ST - Weight Gain and Health Affliction Among Former National Football League Players T2 - American Journal of Medicine TI - Weight Gain and Health Affliction Among Former National Football League Players UR - ://WOS:000451731500028 VL - 131 ID - 1981 ER - TY - JOUR AB - Interactive sonification is an effective tool used to guide individuals when practicing movements. Little research has shown the use of interactive sonification in supporting motor therapeutic interventions for children with autism who exhibit motor impairments. The goal of this research is to study if children with autism understand the use of interactive sonification during motor therapeutic interventions, its potential impact of interactive sonification in the development of motor skills in children with autism, and the feasibility of using it in specialized schools for children with autism. We conducted two deployment studies in Mexico using Go-with-the-Flow, a framework to sonify movements previously developed for chronic pain rehabilitation. In the first study, six children with autism were asked to perform the forward reach and lateral upper-limb exercises while listening to three different sound structures (i.e., one discrete and two continuous sounds). Results showed that children with autism exhibit awareness about the sonification of their movements and engage with the sonification. We then adapted the sonifications based on the results of the first study, for motor therapy of children with autism. In the next study, nine children with autism were asked to perform upper-limb lateral, cross-lateral, and push movements while listening to five different sound structures (i.e., three discrete and two continues) designed to sonify the movements. Results showed that discrete sound structures engage the children in the performance of upper-limb movements and increase their ability to perform the movements correctly. We finally propose design considerations that could guide the design of projects related to interactive sonification AN - WOS:000593001200001 AU - Cibrian, F. L. AU - Ley-Flores, J. AU - Newbold, J. W. AU - Singh, A. AU - Bianchi-Berthouze, N. AU - Tentori, M. DA - Apr DO - 10.1007/s00779-020-01479-z IS - 2 N1 - Cibrian, Franceli L. Ley-Flores, Judith Newbold, Joseph W. Singh, Aneesha Bianchi-Berthouze, Nadia Tentori, Monica Ley Flores, Judith Guadalupe/0000-0003-0168-7601; Newbold, Joseph/0000-0002-0198-3198 1617-4917 Si PY - 2021 SN - 1617-4909 SP - 391-410 ST - Interactive sonification to assist children with autism during motor therapeutic interventions T2 - Personal and Ubiquitous Computing TI - Interactive sonification to assist children with autism during motor therapeutic interventions UR - ://WOS:000593001200001 VL - 25 ID - 1782 ER - TY - JOUR AB - OBJECTIVE: To describe the use of complementary and alternative medicine (CAM) in pediatric functional abdominal pain disorders at a large Midwestern pediatric gastroenterology center. STUDY DESIGN: A survey of patients attending a follow-up visit for functional abdominal pain disorders was completed. Data were collected on demographics, quality of life, use of conventional therapies, patient's opinions, and perception of provider's knowledge of CAM. RESULTS: Of 100 respondents (mean age, 13.3 ± 3.5 years), 47 (60% female) had irritable bowel syndrome, 29 (83% female) had functional dyspepsia, 18 (67% female) had functional abdominal pain, and 6 (83% female) had abdominal migraine (Rome III criteria). Ninety-six percent reported using at least 1 CAM modality. Dietary changes were undertaken by 69%. Multivitamins and probiotics were the most common supplements used by 48% and 33% of respondents, respectively. One-quarter had seen a psychologist. Children with self-reported severe disease were more likely to use exercise (P < .05); those with active symptoms (P < .01) or in a high-income group (P < .05) were more likely to make dietary changes; and those without private insurance (P < .05), or who felt poorly informed regarding CAM (P < .05), were more likely to use vitamins and supplements. Seventy-seven percent of patients described their quality of life as very good or excellent. CONCLUSIONS: The use of CAM in children with functional abdominal pain disorders is common, with a majority reporting a high quality of life. Our study underscores the importance of asking about CAM use and patient/family knowledge of these treatments. AD - Nationwide Children's Hospital, Columbus, OH. Electronic address: Steven.Ciciora@nationwidechildrens.org. Nationwide Children's Hospital, Columbus, OH; The Ohio State University College of Medicine, Department of Biomedical Informatics, Columbus, OH. Nationwide Children's Hospital, Columbus, OH. University of Miami Miller School of Medicine, Miami, FL. AN - 32798564 AU - Ciciora, S. L. AU - Yildiz, V. O. AU - Jin, W. Y. AU - Zhao, B. AU - Saps, M. DA - Dec DO - 10.1016/j.jpeds.2020.08.027 DP - NLM ET - 2020/08/18 KW - Abdominal Pain Academic Medical Centers Adolescent Child Complementary Therapies/*methods/psychology/statistics & numerical data Exercise Female Gastrointestinal Diseases/psychology/*therapy Health Knowledge, Attitudes, Practice Humans Male Probiotics/therapeutic use Quality of Life Surveys and Questionnaires Vitamins/therapeutic use *abdominal migraine *functional abdominal pain *functional dyspepsia *functional gastrointestinal disorders *gastroenterology *irritable bowel syndrome LA - eng N1 - 1097-6833 Ciciora, Steven L Yildiz, Vedat O Jin, Wendy Y Zhao, Becky Saps, Miguel Journal Article United States J Pediatr. 2020 Dec;227:53-59.e1. doi: 10.1016/j.jpeds.2020.08.027. Epub 2020 Aug 13. PY - 2020 SN - 0022-3476 SP - 53-59.e1 ST - Complementary and Alternative Medicine Use in Pediatric Functional Abdominal Pain Disorders at a Large Academic Center T2 - J Pediatr TI - Complementary and Alternative Medicine Use in Pediatric Functional Abdominal Pain Disorders at a Large Academic Center VL - 227 ID - 3822 ER - TY - JOUR AB - OBJECTIVES: There are only a handful of studies examining the clinical differences between patients with and without a family history of migraine. Our aim is to compare the descriptive and clinical properties of patients with and without a family history, and to investigate the association between the migraine burden and disease characteristics and disability of migraine. METHODS: A total of 530 consecutive patients diagnosed with migraine according to the International Headache Society criteria were enrolled into the study. Detailed systemic and neurological examinations, and blood pressure, weight, height, and body mass index measurements, clinical and demographical data, the visual analog scale, allodynia symptom checklist, and the Migraine Disability Assessment Scale (MIDAS) scores were recorded. The groups with and without a family history of migraine were compared statistically. RESULTS: Patients with a positive family history had a higher educational status (high school and higher) (p<0.05) and an increased triggering of pain with physical activity (p=0.013). The age at onset was earlier (p=0.049); disease duration was longer (p=0.030), and MIDAS scores were significantly higher (p=0.028) in patients with a family history of migraine. CONCLUSION: Having a family history of migraine is associated with an earlier age at onset and a longer disease duration, in addition to an increased disability in these patients. The family history may be assumed as a marker of the genetic load in migraineurs; therefore, an early diagnosis and an appropriate management are essential in these patients to avoid migraine-related disability. AD - Department of Neurology, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey. Department of Neurology, Istanbul University Istanbul Faculty of Medicine, Headache Unit, Istanbul, Turkey. AN - 31736021 AU - Çimen Atalar, A. AU - Yalın, OÖ AU - Aslan, H. AU - Baykan, B. DA - Jul DO - 10.14744/agri.2019.26042 DP - NLM ET - 2019/11/19 IS - 3 KW - Adolescent Adult Age Factors Aged Aged, 80 and over Child Disability Evaluation Female *Genetic Predisposition to Disease Humans Hyperalgesia Male Middle Aged Migraine Disorders/*epidemiology/etiology/genetics Pedigree Socioeconomic Factors Turkey/epidemiology Visual Analog Scale Young Adult LA - tur N1 - Çimen Atalar, Arife Yalın, Osman Özgür Aslan, Hüsniye Baykan, Betül Journal Article Turkey Agri. 2019 Jul;31(3):113-121. doi: 10.14744/agri.2019.26042. OP - Ailede migren öyküsü bulunmasının migren özelliklerine etkisi nedir? PY - 2019 SN - 1300-0012 (Print) 1300-0012 SP - 113-121 ST - [What is the impact of having a family history of migraine on migraine characteristics?] T2 - Agri TI - [What is the impact of having a family history of migraine on migraine characteristics?] VL - 31 ID - 3477 ER - TY - JOUR AB - The Functional Disability Inventory (FDI; Walker LS, Greene JW. The functional disability inventory: measuring a neglected dimension of child health status. J Pediatr Psychol 1991; 16:39-58) assesses activity limitations in children and adolescents with a variety of pediatric conditions. This study evaluated the psychometric properties of the FDI in pediatric pain patients. Participants included 596 patients with chronic abdominal pain, ages 8-17, and a subset of their parents (n = 151) who completed the FDI and measures of pain, limitations in school activities, and somatic and depressive symptoms at a clinic visit. Test-retest reliability was high at 2 weeks (child report, .74; parent-report, .64) and moderate at 3 months (child report,.48; parent report,.39). Internal consistency reliability was excellent, ranging from .86 to .91. Validity was supported by significant correlations of child- and parent-report FDI scores with measures of school-related disability, pain, and somatic symptoms. Study results add to a growing body of empirical literature supporting the reliability and validity of the FDI for functional assessment of pediatric patients with chronic pain. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. AN - WOS:000236076000010 AU - Claar, R. L. AU - Walker, L. S. DA - Mar DO - 10.1016/j.pain.2005.12.002 IS - 1-2 N1 - Claar, RL Walker, LS PY - 2006 SN - 0304-3959 SP - 77-84 ST - Functional assessment of pediatric pain patients: Psychometric properties of the Functional Disability Inventory T2 - Pain TI - Functional assessment of pediatric pain patients: Psychometric properties of the Functional Disability Inventory UR - ://WOS:000236076000010 VL - 121 ID - 2739 ER - TY - JOUR AB - BACKGROUND: In Germany, about 70,000 teachers and educational staff were teaching at more than 3,000 special schools during the school year 2010/2011. Nursing services like lifting pupils form a substantial part of the work content of the staff at special schools. Since nursing care often involves carrying and lifting pupils, there is a reason to assume an adverse effect on the musculoskeletal health of teachers and other professionals. With the present study we aimed to describe the prevalence and risk factors of chronic back pain among employees at this type of school. METHODS: The cross-sectional survey was carried out between August 2010 and August 2012 at 13 special schools focusing on motoric and/or holistic development of handicapped children in Rhineland-Palatinate (Germany). Teachers and educational staff were interviewed using a questionnaire. We applied multivariable logistic regression analyses to identify influencing factors of chronic back pain. RESULTS: Altogether 395 persons (response rate: 59.7%) participated in our study. Respondents were mostly female (86.8%) with a mean age of 45 years. The prevalence of chronic back pain was 38.7%. More than 40% reported frequently carrying and lifting heavy loads (>20 kg). Age [adjusted OR = 1.03 (95%-CI 1.00-1.05) for 1-year increase in age], current smoking [adjusted OR = 2.31 (95%-CI 1.27-4.23)], depression/depressive mood [adjusted OR = 1.85 (95%-CI 1.12-3.06)], frequently carrying and lifting heavy loads [adjusted OR = 2.69 (95%-CI 1.53-4.75)], and frequent exposure to environmental impacts [adjusted OR = 2.18 (95%-CI 1.26-3.76)] were influencing factors of chronic back pain in the final multivariable regression model. CONCLUSIONS: A large proportion of teachers and educational staff suffered from chronic back pain in our study, indicating a high need for treatment in this professional group. Increasing age, current smoking, a diagnosed depression/depressive mood, carrying and lifting heavy loads, and exposure to environmental impacts were associated with chronic back pain. Due to the sparse literature on the topic, further studies using a longitudinal design are necessary for a better understanding of the risk factors of chronic back pain. AU - Claus, Matthias AU - Kimbel, Renate AU - Spahn, Daniel AU - Dudenhöffer, Sarah AU - Rose, Dirk-Matthias AU - Letzel, Stephan DA - 2014/02/25/ DO - 10.1186/1471-2474-15-55 DP - PubMed J2 - BMC Musculoskelet Disord KW - Adult Alcoholism Back Pain Body Mass Index Caregivers Child Chronic Pain Cross-Sectional Studies Depression Disabled Children Education, Special Female Germany Humans Male Middle Aged Moving and Lifting Patients Musculoskeletal Diseases Occupational Diseases Risk Factors Schools Smoking Socioeconomic Factors Teaching Workplace LA - eng PY - 2014 SN - 1471-2474 SP - 55 ST - Prevalence and influencing factors of chronic back pain among staff at special schools with multiple and severely handicapped children in Germany T2 - BMC musculoskeletal disorders TI - Prevalence and influencing factors of chronic back pain among staff at special schools with multiple and severely handicapped children in Germany: results of a cross-sectional study UR - http://www.ncbi.nlm.nih.gov/pubmed/24568286 VL - 15 ID - 87 ER - TY - JOUR AB - Objectives Spinal (ie, back and neck) pain often develops as early as during adolescence and can set a trajectory for later life. However, whether early-life spinal-pain-related behavioral responses of missing school/work are predictive of future work absenteeism is yet unknown. We assessed the association of adolescent spinal-pain-related work or school absenteeism with early adulthood work absenteeism in a prospective population-based cohort. Methods Six year follow-up data from the Western Australian Pregnancy Cohort (Raine) study were used (N=476; with a 54% response rate). At age 17, participants reported spinal pain (using the Nordic questionnaire) and adolescent spinal-pain-related work/school absenteeism (with a single item question). Annual total and health-related work absenteeism was assessed with the Health and Work Performance questionnaire distributed in four quarterly text messages during the 23rd year of age. We modelled the association of adolescent spinal-pain-related absenteeism with work absenteeism during early adulthood, using negative binomial regression adjusting for sex, occupation and comorbidities. Results Participants with adolescent low-back or neck pain with work/school absenteeism reported higher total work absenteeism in early adulthood [148.7, standard deviation (SD) 243.4 hours/year], than those without pain [43.7 (SD 95.2) hours/year); incidence rate ratio 3.4 (95% CI 1.2-9.2)]. Comparable findings were found when considering low-back and neck separately, and when considering health-related absenteeism. Conclusions We found a more than three-fold higher risk of work absenteeism in early adulthood among those with adolescent spinal-pain-related absenteeism, compared to those without. These findings suggest that, to keep a sustainable workforce, pain prevention and management should focus on pain-related behaviors as early as in adolescence. AN - WOS:000449167400009 AU - Coenen, P. AU - Smith, A. AU - Kent, P. AU - Harris, M. AU - Linton, S. J. AU - Pransky, G. AU - Beales, D. AU - O'Sullivan, P. AU - Straker, L. DO - 10.5271/sjweh.3744 IS - 5 N1 - Coenen, Pieter Smith, Anne Kent, Peter Harris, Mark Linton, Steven J. Pransky, Glenn Beales, Darren O'Sullivan, Peter Straker, Leon Harris, Mark/O-5084-2015; /B-2407-2013 Harris, Mark/0000-0002-1804-4357; /0000-0002-7786-4128 1795-990x PY - 2018 SN - 0355-3140 SP - 521-529 ST - The association of adolescent spinal-pain-related absenteeism with early adulthood work absenteeism: A six-year follow-up data from a population-based cohort T2 - Scandinavian Journal of Work Environment & Health TI - The association of adolescent spinal-pain-related absenteeism with early adulthood work absenteeism: A six-year follow-up data from a population-based cohort UR - ://WOS:000449167400009 VL - 44 ID - 2048 ER - TY - JOUR AB - BACKGROUND: Untreated immunization pain causes undue distress and contributes to underimmunization through physician, and possibly parental, resistance to multiple simultaneous injections. OBJECTIVE: To compare the efficacies of two pain management methods in reducing immediate immunization injection pain and distress in school-aged children. DESIGN: A randomized, controlled clinical trial of eutectic mixture of local anesthetics (EMLA) cream and vapocoolant spray. PATIENTS: Children aged 4 to 6 years and scheduled to receive diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) during health supervision visits. INTERVENTIONS: Enrolled children were randomized to one of three treatment groups: 1) EMLA cream + distraction; 2) vapocoolant spray + distraction; or 3) distraction alone (control). The specific pharmacologic pain control interventions consisted of EMLA cream (2.5% lidocaine, 2.5% prilocaine [Astra Pharmaceutical Products, Inc, Westborough, MA] $15. 00/patient; applied 60 minutes before injection) and vapocoolant spray (Fluori-Methane [Gebauer Company, Cleveland, OH] $0. 50/patient; applied via spray-saturated cotton ball for 15 seconds immediately before injection). MAIN OUTCOME MEASURES: The blinded investigator (BI) measured (by edited videotape) cry duration and the number of pain behaviors using the Observational Scale of Behavioral Distress. Pain visual analog scales (linear and faces scales) were completed by the child, parent, nurse, and the BI. RESULTS: Sixty-two children, aged 4.5 +/- 0.4 years (mean +/- SD) were randomized. The three treatment groups had similar subject characteristics. All pain measures and cry duration were similar for EMLA and vapocoolant spray. Both EMLA and spray were significantly better than control. Results for spray vs control: cry duration (seconds): 8.5 +/- 21.0 vs 38.6 +/- 50.5; number of pain behaviors: 1.2 +/- 1.9 vs. 3.1 +/- 2.1; child-scored faces scale: 2.0 +/- 2.4 vs. 4.1 +/- 2.3; parent-scored faces scale: 1.6 +/- 1.6 vs. 3.0 +/- 1.7; nurse-scored faces scale: 1.6 +/- 1.2 vs. 3.1 +/- 1.4; and BI-scored faces scale: 1.0 +/- 1.5 vs. 2.4 +/- 1.4. CONCLUSIONS: When combined with distraction, vapocoolant spray significantly reduces immediate injection pain compared with distraction alone, and is equally effective as, less expensive, and faster-acting than EMLA cream. As an effective, inexpensive, and convenient pain control method, vapocoolant spray may help overcome physician and parent resistance to multiple injections that leads to missed opportunities to immunize. AU - Cohen Reis, E. AU - Holubkov, R. DA - 1997/12// DO - 10.1542/peds.100.6.e5 DP - PubMed IS - 6 J2 - Pediatrics KW - Age Factors Anesthetics, Local Attention Child Child, Preschool Chlorofluorocarbons, Methane Diphtheria-Tetanus-Pertussis Vaccine Female Humans Immunization Injections, Intramuscular Male Nebulizers and Vaporizers Pain Pain Measurement Treatment Outcome LA - eng PY - 1997 SN - 1098-4275 SP - E5 ST - Vapocoolant spray is equally effective as EMLA cream in reducing immunization pain in school-aged children T2 - Pediatrics TI - Vapocoolant spray is equally effective as EMLA cream in reducing immunization pain in school-aged children UR - http://www.ncbi.nlm.nih.gov/pubmed/9374583 VL - 100 ID - 123 ER - TY - JOUR AB - Background Dental anxiety is a common problem, related to dental pain, which contributes to irregular dental attendance and avoidance of dental care, resulting in poorer oral health during childhood. Aim To evaluate anxiety, pain and/or discomfort related to dental treatment in 5-to 12-year-old children examined during a public holiday. Methods This cross-sectional survey study was carried out with parental permission in 970 children of both sexes. Socioeconomic status, dental anxiety and dental pain experience data were obtained through a questionnaire answered by parents or guardians. Dental anxiety was measured using the dental anxiety questionnaire (DAQ). The statistical analyses were performed using Pearson's Chi-square test. The intra-examiner agreement was high (kappa = 0.80) and the inter-examiner was kappa = 0.79. Results The prevalence of dental anxiety was 39.4 % and that of a history of dental pain was 44.9 %. Dental anxiety among children was associated with the child never having had a dental appointment. Statistics The anxiety correlated positively with a history of dental pain (p < 0.001), the mother's low level of schooling (p = 0.037), parents' dental anxiety (p < 0.001), and negatively with visits to the dentist (p < 0.001). Conclusion A high percentage of children presented with dental anxiety and a history of dental pain. AN - WOS:000214119900004 AU - Colares, V. AU - Franca, C. AU - Ferreira, A. AU - Amorim, H. A. AU - Oliveira, M. C. A. DA - Feb DO - 10.1007/s40368-012-0001-8 IS - 1 N1 - Colares, V. Franca, C. Ferreira, A. Amorim Filho, H. A. Oliveira, M. C. A. de Andrade Amorim, Viviane Colares Soares/O-9320-2019 de Andrade Amorim, Viviane Colares Soares/0000-0003-2912-2100 1996-9805 PY - 2013 SN - 1818-6300 SP - 15-19 ST - Dental anxiety and dental pain in 5- to 12-year-old children in Recife, Brazil T2 - European Archives of Paediatric Dentistry TI - Dental anxiety and dental pain in 5- to 12-year-old children in Recife, Brazil UR - ://WOS:000214119900004 VL - 14 ID - 2386 ER - TY - JOUR AB - Juvenile primary fibromyalgia syndrome (JPFS) is a chronic musculoskeletal pain syndrome affecting children and adolescents. In part one of this review, we discussed the epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis of JPFS. Part two focuses on the treatment and prognosis of JPFS. Early intervention is important. The standard of care is multidisciplinary, combining various modalities-most importantly, exercise and cognitive behavioral therapy. Prognosis varies and symptoms may persist into adulthood. AN - WOS:000651807300001 AU - Coles, M. L. AU - Uziel, Y. C7 - 74 DA - May DO - 10.1186/s12969-021-00529-x IS - 1 N1 - Coles, Maya Levy Uziel, Yosef 1546-0096 PY - 2021 ST - Juvenile primary fibromyalgia syndrome: A Review- Treatment and Prognosis T2 - Pediatric Rheumatology TI - Juvenile primary fibromyalgia syndrome: A Review- Treatment and Prognosis UR - ://WOS:000651807300001 VL - 19 ID - 1738 ER - TY - JOUR AB - Objective.-The aim of this prospective study is to assess the time lapse between the onset of recurring headache and the correct diagnosis in a cohort of pediatric patients attending an Italian children's headache center for the first time. Methods.-One hundred and one patients and parents, referred to the Pediatric Headache Centre of San Raffaele Hospital in Milan, Italy, underwent a semi-structured interview to ascertain features of headache since onset (clinical and family history, presence of childhood periodic syndromes, previously undergone instrumental exams and specialists' examinations before the correct diagnosis, past and current treatment). All patients were evaluated by expert neurologists and their headache was classified according to the International Classification of Headache Disorders II (2004). Results.-The median time delay from the onset of the first episode of recurrent headache to definite diagnosis was 20 months (interquartile range 12 to 36 months). A correlation with younger age and a more delayed headache diagnosis was found (r Spearman = 0.25; P = .039). An association between diagnostic delay and positive family history (median 24 months [12 to 48] vs 12 [6 to 24]; P = .014) or female gender (median 18 months [12 to 42] vs 12 [5 to 30]; P trend = .070) was also evident. Notably, 76 out of 101 patients referred to our Center received an appropriate diagnosis according to International Classification of Headache Disorders II at the time of our visit only. Of note, up to 21% of this group were previously misdiagnosed (for epilepsy 43%, sinusitis 38%, or other diseases 19%), a fact that contributed to a longer time of clinical assessment (median 39 months) before reaching a correct diagnosis. The other group of 80 patients (79%) did not receive a specific diagnosis and treatment, and were not studied until their symptom became chronic and disabling. Conclusion.-Pediatric headache is still under-diagnosed and not adequately considered as a health problem in the medical community as well as social settings. There is a need for educational programs regarding headache involving not only general practitioners, pediatricians, and neurologists, but also the general population. These are desirable in order to raise awareness of such a condition and, accordingly, treat children accurately. AN - WOS:000294548200008 AU - Colombo, B. AU - Dalla Libera, D. AU - De Feo, D. AU - Pavan, G. AU - Annovazzi, P. O. AU - Comi, G. DA - Sep DO - 10.1111/j.1526-4610.2011.01976.x IS - 8 N1 - Colombo, Bruno Dalla Libera, Dacia De Feo, Donatella Pavan, Giulia Annovazzi, Pietro Osvaldo Comi, Giancarlo Dalla Libera, Dacia/0000-0001-5028-4177; Annovazzi, Pietro/0000-0003-0279-0707 1526-4610 PY - 2011 SN - 0017-8748 SP - 1267-1273 ST - Delayed Diagnosis in Pediatric Headache: An Outpatient Italian Survey T2 - Headache TI - Delayed Diagnosis in Pediatric Headache: An Outpatient Italian Survey UR - ://WOS:000294548200008 VL - 51 ID - 2479 ER - TY - JOUR AB - OBJECTIVE: Optimal diagnosis and management of median arcuate ligament (MAL) syndrome (MALS) remains unclear in contemporary practice. The advent and evolution of laparoscopic and endovascular techniques has redirected management toward a less invasive therapeutic algorithm. This study examined our contemporary outcomes of patients treated for MALS. METHODS: All patients treated for MALS at Dartmouth-Hitchcock Medical Center from 2000 to 2013 were retrospectively reviewed. Demographics and comorbidities were recorded. Freedom from symptoms and freedom from reintervention were the primary end points. Return to work or school was assessed. Follow-up by clinic visits and telephone allowed quantitative comparisons among the patients. RESULTS: During the study interval, 21 patients (24% male), with a median age of 42 years, were treated for MALS. All patients complained of abdominal pain in the presence of a celiac stenosis, 16 (76%) also reported weight loss at the time of presentation, and 57% had a concomitant psychiatric history. Diagnostic imaging most commonly used included duplex ultrasound (81%), computed tomography angiography (66%), angiography (57%), and magnetic resonance angiography (5%). Fourteen patients (67%) underwent multiple diagnostic studies. All patients underwent initial laparoscopic MAL release. Seven patients (33%) underwent subsequent celiac stent placement in the setting of recurrent or unresolved symptoms with persistent celiac stenosis at a mean interval of 49 days. Two patients required surgical bypass after an endovascular intervention failed. The 6-month freedom from symptoms was 75% and freedom from reintervention was 64%. Eighteen patients (81%) reported early symptom improvement and weight gain, and 66% were able to return to work. CONCLUSIONS: A multidisciplinary treatment approach using initial laparoscopic release and subsequent stent placement and bypass surgery provides symptom improvement in most patients treated for MALS. The potential placebo effect, however, remains uncertain. A significant minority of patients will require reintervention, justifying longitudinal surveillance and prudent patient selection. Patients can anticipate functional recovery, weight gain, and return to work with treatment. AD - Section of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH. Electronic address: jesse.a.columbo@hitchcock.org. Section of Minimally Invasive Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH. Section of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH. AN - 25758451 AU - Columbo, J. A. AU - Trus, T. AU - Nolan, B. AU - Goodney, P. AU - Rzucidlo, E. AU - Powell, R. AU - Walsh, D. AU - Stone, D. C2 - PMC5292272 C6 - NIHMS844838 DA - Jul DO - 10.1016/j.jvs.2015.01.050 DP - NLM ET - 2015/03/12 IS - 1 KW - Abdominal Pain/etiology Academic Medical Centers Adolescent Adult Aged *Angioplasty, Balloon/adverse effects/instrumentation Celiac Artery/*abnormalities/surgery Constriction, Pathologic/complications/diagnosis/*surgery Decompression, Surgical/adverse effects/*methods Diagnostic Imaging/methods Female Humans *Laparoscopy/adverse effects Male Median Arcuate Ligament Syndrome Middle Aged New Hampshire Predictive Value of Tests Recurrence Retrospective Studies Return to Work Stents Time Factors Treatment Outcome Weight Gain Weight Loss Young Adult LA - eng N1 - 1097-6809 Columbo, Jesse A Trus, Thadeus Nolan, Brian Goodney, Philip Rzucidlo, Eva Powell, Richard Walsh, Daniel Stone, David K08 HL105676/HL/NHLBI NIH HHS/United States Journal Article J Vasc Surg. 2015 Jul;62(1):151-6. doi: 10.1016/j.jvs.2015.01.050. Epub 2015 Mar 7. PY - 2015 SN - 0741-5214 (Print) 0741-5214 SP - 151-6 ST - Contemporary management of median arcuate ligament syndrome provides early symptom improvement T2 - J Vasc Surg TI - Contemporary management of median arcuate ligament syndrome provides early symptom improvement VL - 62 ID - 3880 ER - TY - JOUR AB - Introduction: Infliximab is a promising advance in the treatment of pediatric inflammatory bowel disease. Infliximab is an effective therapy for selected children with Crohn disease but is both costly and time consuming. Objectives: To analyze our center's experience with a program of home-based infliximab infusion. Methods: Between September, 2001, and October, 2003 we reviewed the charts of all children receiving home infliximab infusions focusing on cost, safety, and patient satisfaction. Children were enrolled in the home infusion program if they were compliant with hospital-based infliximab infusions and other medications, had no adverse events during hospital-based infliximab infusions, were in remission and had access to experienced pediatric homecare nursing. \ Results: Ten children received 59 home infusions with a dose range of 7.5 to 10 mg/kg/dose. The calculated average savings per patient was $1335/100 mg infliximab. Home infusions ranged from 2 to 5 hours. Since infusions could be performed any day of the week, school absenteeism was decreased. The average patient satisfaction rating for home infusions was 9 on a scale from 1 to 10 (10 = most satisfied). Three patients experienced difficulty with IV access requiring multiple attempts, but all were able to receive their infusions. One infusion was stopped because of arm pain above the IV site. This patient had his next infusion in the hospital before returning to the home infusion program. No severe adverse events (palpitations, blood pressure instability, hyperemia, respiratory symptoms) occurred during home infusions. Conclusions: In our carefully selected patients, infliximab infusions administered at home were safe and are cost-effective. Patients and families preferred home infusions, since time missed from school and work was reduced. AN - WOS:000226148300012 AU - Condino, A. A. AU - Fidanza, S. AU - Hoffenberg, E. J. DA - Jan DO - 10.1097/00005176-200501000-00012 IS - 1 N1 - Condino, AA Fidanza, S Hoffenberg, EJ Hoffenberg, Edward/0000-0001-5179-489X 1536-4801 PY - 2005 SN - 0277-2116 SP - 67-69 ST - A home infliximab infusion program T2 - Journal of Pediatric Gastroenterology and Nutrition TI - A home infliximab infusion program UR - ://WOS:000226148300012 VL - 40 ID - 2777 ER - TY - JOUR AB - OBJECTIVE: To determine preliminary outcomes of a treatment for refractory pediatric migraine that integrates outpatient dihydroergotamine (DHE) infusion with interdisciplinary adjunctive care. BACKGROUND: Limited data are available to inform treatment of refractory migraine in children. Intravenous DHE therapy has shown promise but has been implemented in costly inpatient settings and in isolation of nonpharmacological strategies shown to enhance analgesia and functional improvement. METHODS: We conducted a retrospective chart review of 36 patients ages 11-18 with refractory migraine who underwent a pilot treatment program in an outpatient neurology clinic. The treatment integrated up to 5 days of outpatient DHE infusion with adjunctive nonpharmacological care (pain coping skills training, massage, aromatherapy, and school reintegration support). Changes in headache, healthcare utilization, and functional limitations were assessed as indicators of treatment response through 3-month follow-up. RESULTS: On average, headache intensity declined (M = 5.8 ± 2.5 to M = 2.4 ± 2.7; P < .0001) during the treatment period and remained statistically significantly improved through 3-month follow-up. Headache frequency decreased by a mean of 1.5 days per week (M = 6.7 ± 1.0 vs M = 5.2 ± 2.7, P = .012) through 3-month follow-up, with a 27% reduction (from 0.91 to 0.66) in the proportion of patients reporting a continuous headache (P = .009). Over this same follow-up period, there was a reduction in school days missed per month (median [25th, 75th percentile]: 4.5 [0, 21.0] vs 0 [0.0, 0.5]). There also were reductions in headache-related visits per month to the emergency department and medical providers. Adverse effects were common but typically minor and transient. CONCLUSIONS: Combining outpatient DHE infusion with interdisciplinary adjunctive care has promise as an effective treatment option for adolescents with refractory migraine. AD - Division of Developmental and Behavioral Sciences, Children's Mercy Hospital, Kansas City, MO, USA. University of Missouri Kansas City School of Medicine, Kansas City, MO, USA. Division of Neurology, Children's Mercy Hospital, Kansas City, MO, USA. AN - 31626335 AU - Connelly, M. AU - Sekhon, S. AU - Stephens, D. AU - Boorigie, M. AU - Bickel, J. DA - Jan DO - 10.1111/head.13685 DP - NLM ET - 2019/10/19 IS - 1 KW - Adolescent *Ambulatory Care Analgesics, Non-Narcotic/*administration & dosage *Aromatherapy Child *Clinical Protocols Combined Modality Therapy Dihydroergotamine/*administration & dosage Female Follow-Up Studies Humans Infusions, Intravenous Male *Massage Migraine Disorders/drug therapy/physiopathology/*therapy *Outcome Assessment, Health Care Outpatient Clinics, Hospital Pilot Projects *Psychotherapy Retrospective Studies Schools Social Support *dihydroergotamine *interdisciplinary *nonpharmacological treatment *pediatric *refractory migraine LA - eng N1 - 1526-4610 Connelly, Mark Orcid: 0000-0001-8157-8901 Sekhon, Subhjit Stephens, Dane Boorigie, Madeline Bickel, Jennifer Journal Article United States Headache. 2020 Jan;60(1):101-109. doi: 10.1111/head.13685. Epub 2019 Oct 18. PY - 2020 SN - 0017-8748 SP - 101-109 ST - Enhancing Outpatient Dihydroergotamine Infusion With Interdisciplinary Care to Treat Refractory Pediatric Migraine: Preliminary Outcomes From the Comprehensive Aggressive Migraine Protocol ("CAMP") T2 - Headache TI - Enhancing Outpatient Dihydroergotamine Infusion With Interdisciplinary Care to Treat Refractory Pediatric Migraine: Preliminary Outcomes From the Comprehensive Aggressive Migraine Protocol ("CAMP") VL - 60 ID - 3053 ER - TY - JOUR AB - IntroductionEntrapment neuropathies are infrequent in children, and therefore remain unrecognized. The incidence of radial, median, and cubital mononeuropathies are all similar. Despite the rarity of such cases, extensive, albeit scattered, literature has accumulated concerning entrapment neuropathies in children.ObjectiveTo the literature concerning entrapment neuropathies in children.MethodsA systematic review of the existing literature has been made.ResultsThe management of chronic pediatric pain is very important in such patients to prevent youths from experiencing prolonged absences from school, sports, or other productive activities, and limit the psychological burden of chronic disease. Nonsurgical treatment of both cubital and carpal tunnel syndromes has been disappointing in pediatric patients, with only limited success; and, to date, there is no clear explanation for the outcome differences generated by nonsurgical management between adults and youths. Simple decompression of the ulnar nerve at the elbow also has much higher rates of failure in children than in adults.ConclusionsThe presence of an entrapment neuropathy (specially carpal tunnel syndrome) in a pediatric-age patient should alert medical care providers to the potential of some underlying genetic condition or syndrome. AN - WOS:000456311300008 AU - Costales, J. R. AU - Socolovsky, M. AU - Lazaro, J. A. S. AU - Costales, D. R. DA - Jan DO - 10.1007/s00381-018-3975-7 IS - 1 N1 - Robla Costales, Javier Socolovsky, Mariano Sanchez Lazaro, Jaime A. Robla Costales, David Sanchez-Lazaro, Jaime/AAH-4937-2020; Socolovsky, Mariano/V-1568-2019 Sanchez-Lazaro, Jaime/0000-0002-6517-7101; Robla, David/0000-0003-1246-2918; Socolovsky, Mariano/0000-0002-0667-3463 1433-0350 PY - 2019 SN - 0256-7040 SP - 37-45 ST - Peripheral nerve injuries in the pediatric population: a review of the literature. Part II: entrapment neuropathies T2 - Childs Nervous System TI - Peripheral nerve injuries in the pediatric population: a review of the literature. Part II: entrapment neuropathies UR - ://WOS:000456311300008 VL - 35 ID - 1970 ER - TY - JOUR AB - BACKGROUND: Complementary or integrative care therapies are promising adjunctive approaches to pain management for pediatric inpatients that are currently underused and understudied. The purpose of this study was to examine the potential benefits of integrative care therapies delivered to hospitalized children and adolescents at a large Midwestern academic pediatric medical center over a 1-year period. METHODS: A retrospective chart review of an inpatient clinical database maintained by integrative care therapists over a 1-year period was used for the current study. Pre/post pain and relaxation scores associated with the delivery of inpatient integrative care therapies (primarily massage therapy and healing touch) were examined. RESULTS: Five-hundred nineteen hospitalized children and adolescents were treated by integrative care therapists for primarily pain or anxiety needs. Patients had a mean age of 10.2 years (standard deviation, 7.0), 224 were female (43%), 383 were white (74%), and most (393 [77%]) received massage therapy. Mean pain and relaxation scores decreased significantly from pre- to post-therapy across all demographic and clinical subgroups (p≤.001). CONCLUSIONS: Although integrative care therapies are increasingly requested and offered in children's hospitals, provision of these approaches is driven primarily by consumer demand rather than evidence-informed practice. Future controlled studies should examine the incremental effects of integrative care therapies as an adjunct to conventional treatment, assess how these therapies work mechanistically, and determine whether they improve outcomes, such as pain and cost, for hospitalized children and adolescents. AD - 1 Department of Family and Community Medicine, Division of Integrative Medicine, Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH. AN - 24175871 AU - Cotton, S. AU - Luberto, C. M. AU - Bogenschutz, L. H. AU - Pelley, T. J. AU - Dusek, J. C2 - PMC3924796 DA - Feb DO - 10.1089/acm.2013.0306 DP - NLM ET - 2013/11/02 IS - 2 KW - Adolescent Adolescent, Hospitalized/psychology/*statistics & numerical data Anxiety/therapy Child Child, Hospitalized/psychology/*statistics & numerical data Complementary Therapies/*methods Female Humans Integrative Medicine/*methods Male Pain Management/methods/*statistics & numerical data Retrospective Studies LA - eng N1 - 1557-7708 Cotton, Sian Luberto, Christina M Bogenschutz, Lois H Pelley, Terri J Dusek, Jeffrey R01 AT006518/AT/NCCIH NIH HHS/United States Journal Article Research Support, Non-U.S. Gov't J Altern Complement Med. 2014 Feb;20(2):98-102. doi: 10.1089/acm.2013.0306. Epub 2013 Oct 31. PY - 2014 SN - 1075-5535 (Print) 1075-5535 SP - 98-102 ST - Integrative care therapies and pain in hospitalized children and adolescents: a retrospective database review T2 - J Altern Complement Med TI - Integrative care therapies and pain in hospitalized children and adolescents: a retrospective database review VL - 20 ID - 3205 ER - TY - JOUR AB - Objectives.-To examine the feasibility of administering behavioral migraine management training by telephone (TAT) and the acceptability of TAT to adolescents with episodic migraine. Methods.-34 adolescents (M = 14 years) with migraine (M = 3.6 migraines/month; M = 29.2 hours duration) were randomly assigned to a two-month telephone administered behavioral migraine management program (TAT) or to a standard Triptan Treatment (TT). Outcome was assessed at three- and eight-month evaluations. Participants completed a daily migraine diary that yielded information about number, duration and severity of migraines and migraine-related disability, as well as the Migraine Specific Quality of Life Questionnaire - Adolescent. In addition, TAT participants evaluated key aspects of the TAT program using 5-point Likert-like rating scales. Lastly, the ability of adolescents to demonstrate specific headache management skills following TAT was assessed. Results.-All fifteen adolescents who entered TAT successfully demonstrated either full or partial mastery of two or more skills and nearly half demonstrated at least partial mastery of all four skills evaluated. Ninety three percent of the TAT participants reported having a positive relationship with their phone counselor. They also reported a preference for the telephone-based treatment over in-clinic visits and rated the manual and tapes as helpful. Treatment effects (in terms of percent improvement) ranged from consistently large across both evaluations for improvement in number of migraines (54% and 71%), disability equivalent hours (80% and 63%) and quality of life (44% and 48%), to moderate or variable for migraine duration (35% and 23%) and severity (30% and 34%). The TT group also showed clinically meaningful reductions in headache parameters and improvements in quality of life. Conclusions.-Completion rates for TAT were high; adolescents evaluated their experience with TAT positively and were able to exhibit key behavioral headache management skills following treatment. While clinically significant improvements in migraine and migraine-related disability/quality of life were observed with both TAT and treatment as usual (triptan therapy), the small study size and the absence of a control group do not permit conclusions about the effectiveness of either treatment. Nonetheless these results indicate TAT may be a promising treatment format for improving access to behavioral treatments for underserved adolescents and justifies further evaluation of TAT both alone and in combination with drug therapy. AN - WOS:000250079500004 AU - Cottrell, C. AU - Drew, J. AU - Gibson, J. AU - Holroyd, K. AU - O'Donnell, F. DA - Oct DO - 10.1111/j.1526-4610.2007.00804.x IS - 9 N1 - Cottrell, Constance Drew, Jana Gibson, Jessica Holroyd, Kenneth O'Donnell, Francis 1526-4610 PY - 2007 SN - 0017-8748 SP - 1293-1302 ST - Feasibility assessment of telephone-administered behavioral treatment for adolescent migraine T2 - Headache TI - Feasibility assessment of telephone-administered behavioral treatment for adolescent migraine UR - ://WOS:000250079500004 VL - 47 ID - 2677 ER - TY - JOUR AB - OBJECTIVE: To examine depression and baseline neurocognitive function and concussion symptoms in male and female high school and college athletes. DESIGN: Cross sectional. SETTING: Athletes completed testing at a designated computer laboratory at high schools and colleges. PARTICIPANTS: Participants included 1616 collegiate (n = 837) and high school (n = 779) athletes from 3 states participating in a variety of competitive sports. INTERVENTIONS: Participants completed the baseline Immediate Postconcussion Assessment and Cognitive Test (ImPACT), symptom inventory, and Beck Depression Inventory II (BDI-II). MAIN OUTCOME MEASURES: Between-group comparisons for depression groups on ImPACT composite scores (verbal and visual memory, reaction time, motor processing speed), total symptoms, and symptom cluster (sleep, cognitive, emotional, somatic/migraine) scores. Between-group comparisons for age and sex on BDI-II, ImPACT, total symptoms, and symptom cluster scores. RESULTS: The severe depression group scored worse on visual memory and reported more total, somatic/migraine, cognitive, emotional, and sleep symptoms than less depressed groups. High school athletes reported more somatic/migraine symptoms than collegiate athletes, whereas collegiate athletes reported more emotional and sleep symptoms than high school athletes. Women had higher verbal memory and reported more cognitive, emotional, and sleep symptom clusters compared with men. Women outperformed men on verbal memory, whereas collegiate athletes outperformed high school athletes on processing speed. CONCLUSIONS: Athletes with severe depression scored lower on visual memory than those with minimal depression. Athletes with severe depression report more concussion symptoms than athletes with minimal and moderate depression scores. Symptoms of depression should be included in baseline assessments to help disentangle depression from concussion symptoms. AD - Department of Kinesiology, Michigan State University, East Lansing, Michigan 48824, USA. covassin@msu.edu AN - 22246342 AU - Covassin, T. AU - Elbin, R. J., 3rd AU - Larson, E. AU - Kontos, A. P. DA - Mar DO - 10.1097/JSM.0b013e31823403d2 DP - NLM ET - 2012/01/17 IS - 2 KW - Adolescent Age Factors Analysis of Variance Athletes Athletic Injuries/*diagnosis/physiopathology Brain Concussion/*diagnosis/physiopathology Cognitive Dysfunction/*diagnosis/physiopathology Cross-Sectional Studies Depression/*diagnosis/physiopathology Female Humans Male Migraine Disorders/diagnosis/physiopathology Neurologic Examination *Neuropsychological Tests Severity of Illness Index Sex Factors Sleep Wake Disorders/diagnosis/physiopathology Young Adult LA - eng N1 - 1536-3724 Covassin, Tracey Elbin, Robert J 3rd Larson, Elizabeth Kontos, Anthony P Journal Article United States Clin J Sport Med. 2012 Mar;22(2):98-104. doi: 10.1097/JSM.0b013e31823403d2. PY - 2012 SN - 1050-642x SP - 98-104 ST - Sex and age differences in depression and baseline sport-related concussion neurocognitive performance and symptoms T2 - Clin J Sport Med TI - Sex and age differences in depression and baseline sport-related concussion neurocognitive performance and symptoms VL - 22 ID - 3761 ER - TY - JOUR AB - BACKGROUND: Multiple concussions have been associated with prolonged symptoms, recovery time, and risk for future concussions. However, very few studies have examined the effect of multiple concussions on neurocognitive performance and the recently revised symptom clusters using a large database. PURPOSE: To examine concussed athletes with a history of 0, 1, 2, or ≥3 concussions on neurocognitive performance and the recently revised symptom clusters. STUDY DESIGN: Cohort study (prognosis); Level of evidence, 2. METHODS: The independent variables were concussion group (0, 1, 2, and ≥3 concussions) and time (baseline, 3 days, and 8 days). The dependent variables were neurocognitive test scores as measured by the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) neurocognitive test battery (verbal and visual memory, processing speed, and reaction time) and 4 concussion symptom clusters (migraine-cognitive-fatigue, affective, somatic, and sleep). All concussed athletes (n = 596) were administered the ImPACT test at a mean 2.67 ± 1.98 and 7.95 ± 4.46 days after injury. A series of 4 (concussion group) × 3 (time) repeated-measures analyses of covariance (age = covariate) were performed on ImPACT composite scores and symptom clusters. RESULTS: Concussed athletes with ≥3 concussions were still impaired 8 days after a concussion compared with baseline scores on verbal memory (P < .001), reaction time (P < .001), and migraine-cognitive-fatigue symptoms (P < .001). There were no significant findings on the remaining dependent variables. CONCLUSION: Concussed athletes with a history of ≥3 concussions take longer to recover than athletes with 1 or no previous concussion. Future research should concentrate on validating the new symptom clusters on multiple concussed athletes, examining longer recovery times (ie, >8 days) among athletes with multiple concussions. AD - Tracey Covassin, AT, Department of Kinesiology, Michigan State University, 308 West Circle Drive, Room 105, East Lansing, MI 48824. covassin@msu.edu. AN - 23959963 AU - Covassin, T. AU - Moran, R. AU - Wilhelm, K. DA - Dec DO - 10.1177/0363546513499230 DP - NLM ET - 2013/08/21 IS - 12 KW - Adolescent Adult Affect Athletes/psychology Athletic Injuries/complications/*psychology Brain Concussion/complications/*psychology *Cognition Cognition Disorders/*etiology/prevention & control Cohort Studies Fatigue/etiology Female Humans Incidence Male *Memory Migraine Disorders/etiology Neuropsychological Tests *Reaction Time Schools Sleep Young Adult cognitive testing multiple concussions symptoms LA - eng N1 - 1552-3365 Covassin, Tracey Moran, Ryan Wilhelm, Kristyn Journal Article United States Am J Sports Med. 2013 Dec;41(12):2885-9. doi: 10.1177/0363546513499230. Epub 2013 Aug 19. PY - 2013 SN - 0363-5465 SP - 2885-9 ST - Concussion symptoms and neurocognitive performance of high school and college athletes who incur multiple concussions T2 - Am J Sports Med TI - Concussion symptoms and neurocognitive performance of high school and college athletes who incur multiple concussions VL - 41 ID - 3860 ER - TY - JOUR AB - OBJECTIVES: To assess the effects of a 9-week yoga intervention on chronic nonspecific neck pain 12 months after completion. DESIGN: Twelve-month follow-up of the pooled data of both arms of a randomized, controlled trial. SETTING: Department of Internal and Integrative Medicine at an academic teaching hospital. SUBJECTS: Fifty-one patients with chronic nonspecific neck pain (mean age 47.8 years; 82.4% female). INTERVENTIONS: A 9-week yoga group intervention. OUTCOME MEASURES: Neck pain intensity (100-mm visual analog scale), functional disability (neck disability index), health-related quality of life (short-form 36 questionnaire, SF-36), generic disability (days with restricted activities), and global improvement. RESULTS: From baseline to 12-month follow-up, pain intensity improved from 48.81 ± 17.71 to 32.31 ± 20.68 (P < 0.001), neck-related disability decreased from 25.26 ± 9.02 to 19.49 ± 11.52 (P = 0.001), and bodily pain in the SF-36 improved from 49.37 ± 12.40 to 59.26 ± 17.57 (P = 0.005). Improvements in pain intensity were predicted by weekly minutes of yoga practice during the past 4 weeks (r(2)  = 0.12, P = 0.028); improved neck-related disability (r(2)  = 0.24, P = 0.001) and bodily pain (r(2)  = 0.26, P = 0.006) were predicted by regular yoga practice during the past 12 months. Generic disability did not decrease significantly. Twenty-four patients (68.6%) rated their health as at least somewhat improved. CONCLUSIONS: A 9-week yoga intervention improved pain and neck-related disability for at least 12 months after completion. Sustained yoga practice seems to be the most important predictor of long-term effectiveness. AD - Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. h.cramer@kliniken-essen-mitte.de AN - 23387504 AU - Cramer, H. AU - Lauche, R. AU - Hohmann, C. AU - Langhorst, J. AU - Dobos, G. DA - Apr DO - 10.1111/pme.12053 DP - NLM ET - 2013/02/08 IS - 4 KW - Adolescent Adult Chronic Disease Disability Evaluation Educational Status Female Follow-Up Studies Humans Male Middle Aged Neck Pain/*therapy Pain Measurement Patient Compliance Quality of Life Regression Analysis Socioeconomic Factors Treatment Outcome *Yoga Young Adult LA - eng N1 - 1526-4637 Cramer, Holger Lauche, Romy Hohmann, Claudia Langhorst, Jost Dobos, Gustav Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't England Pain Med. 2013 Apr;14(4):541-8. doi: 10.1111/pme.12053. Epub 2013 Feb 6. PY - 2013 SN - 1526-2375 SP - 541-8 ST - Yoga for chronic neck pain: a 12-month follow-up T2 - Pain Med TI - Yoga for chronic neck pain: a 12-month follow-up VL - 14 ID - 3714 ER - TY - JOUR AB - OBJECTIVE: The aim of this study was to evaluate the incidence of anxiety and rates of anxiety treatment in emergency department (ED) patients presenting with pain-related complaints. METHODS: We prospectively evaluated patients in an urban academic tertiary care hospital ED from 2000 through 2010. We enrolled a convenience sample of adult patients presenting with pain and recorded patient complaint, medication administration, satisfaction, and pain and anxiety scores throughout their stay. We stratified patients into 4 different groups according to anxiety score at presentation (0, none; 1-4, mild; 5-7, moderate; 8-10, severe). RESULTS: We enrolled 10 664 ED patients presenting with pain-related complaints. Patients reporting anxiety were as follows: 25.7%, none; 26.1%, mild; 23.7%, moderate; and 24.5%, severe. Although 48% of patients described moderate to severe anxiety at ED presentation and 60% were willing to take a medication for anxiety, only 1% received anxiety treatment. Thirty-five percent of patients still reported moderate/severe anxiety at discharge. Severe anxiety at ED presentation was associated with increased demand for pain medication (odds ratio [OR], 1.40; 95% confidence interval [CI], 1.10-1.79) and anxiety medication (OR, 4.34; 95% CI, 3.68-5.11) during the ED stay and decreased satisfaction with the treatment of pain (β coefficient = -0.328; P < .001). After adjusting for age, sex, and presentation pain scores, patients who reported severe anxiety were more likely to receive an analgesic (OR, 1.33; 95% CI, 1.19-1.50) and an opioid (OR, 1.25; 95% CI, 1.11-1.41) during the ED stay. CONCLUSION: Anxiety may be underrecognized and undertreated in patients presenting with pain-related complaints. Patients reporting severe anxiety were less likely to report satisfaction with the treatment of their pain, despite higher rates of analgesic administration. AD - University of Utah, Salt Lake City, UT 84132, USA. Philip.craven@hsc.utah.edu AN - 22981626 AU - Craven, P. AU - Cinar, O. AU - Madsen, T. DA - Feb DO - 10.1016/j.ajem.2012.08.009 DP - NLM ET - 2012/09/18 IS - 2 KW - Adolescent Adult Analgesics/*therapeutic use Anxiety/*complications/diagnosis/drug therapy/epidemiology *Emergency Service, Hospital Female Humans Incidence Logistic Models Male Middle Aged Multivariate Analysis Pain/complications/*drug therapy/psychology Pain Management/*psychology Pain Measurement Patient Satisfaction/statistics & numerical data Prospective Studies Self Report Severity of Illness Index Treatment Outcome Young Adult LA - eng N1 - 1532-8171 Craven, Philip Cinar, Orhan Madsen, Troy Clinical Trial Journal Article United States Am J Emerg Med. 2013 Feb;31(2):313-8. doi: 10.1016/j.ajem.2012.08.009. Epub 2012 Sep 13. PY - 2013 SN - 0735-6757 SP - 313-8 ST - Patient anxiety may influence the efficacy of ED pain management T2 - Am J Emerg Med TI - Patient anxiety may influence the efficacy of ED pain management VL - 31 ID - 3829 ER - TY - JOUR AB - This study investigated the community integration, self-esteem, and vocational identity of 106 persons with disabilities, most of whom were unemployed and attending a vocational rehabilitation agency. Community integration was mediated by type of disability; that is, community integration levels were significantly greater among persons with a psychiatric disability and those with physical (non-pain) or sensory disabilities, than among those with acquired brain injury or chronic pain. Higher levels of self-esteem were reported by persons with chronic pain, physical (non-pain), or sensory disabilities than among persons with acquired brain injury or a psychiatric disability. Persons who regularly received both vocational and psychological/psychiatric services reported significantly lower levels of self-esteem and vocational identity than those persons who received vocational services only. Community integration was, however, independent of type of service received. Implications for rehabilitation professionals are discussed. AN - WOS:A1996UY81600009 AU - Crisp, R. DA - Jul DO - 10.1080/00050069608260193 IS - 2 N1 - Crisp, R PY - 1996 SN - 0005-0067 SP - 133-137 ST - Community integration, self-esteem, and vocational identity among persons with disabilities T2 - Australian Psychologist TI - Community integration, self-esteem, and vocational identity among persons with disabilities UR - ://WOS:A1996UY81600009 VL - 31 ID - 2925 ER - TY - JOUR AB - Functional somatic symptoms signal distress and reflect an activation of the body's stress-regulation systems. Many different types of stressors - physical, emotional or both - may activate the body's stress-regulation systems. If stress-related disruptions are extreme or are not limited in time, functional somatic symptoms may emerge, signalling that the body remains in a state of activation and somatic distress. In this paper, we describe the development of therapeutic fact sheets, which are used as part of our multimodal, family-based, rehabilitation intervention for children and adolescents presenting with functional somatic symptoms. The fact sheets provide information about functional somatic symptoms - including their assessment and treatment - from a stress-system framework. They are used in the context of a family intervention to facilitate engagement with the family and to reduce parental anxiety and reactivity. Whilst the fact sheets were initially developed for parents, over time we found that the sheets were also useful in managing anxiety in the medical and school systems. A key goal of this article is to share this resource with other clinicians working with children/adolescents with functional somatic symptoms. AN - WOS:000344475700004 AU - Cruz, C. AU - Chudleigh, C. AU - Savage, B. AU - Kozlowska, K. DA - Sep DO - 10.1002/anzf.1059 IS - 3 N1 - Cruz, Catherine Chudleigh, Catherine Savage, Blanche Kozlowska, Kasia 1467-8438 PY - 2014 SN - 0814-723X SP - 223-243 ST - Therapeutic Use of Fact Sheets in Family Therapy with Children and Adolescents With Functional Somatic Symptoms T2 - Australian and New Zealand Journal of Family Therapy TI - Therapeutic Use of Fact Sheets in Family Therapy with Children and Adolescents With Functional Somatic Symptoms UR - ://WOS:000344475700004 VL - 35 ID - 2289 ER - TY - JOUR AB - We reviewed the referral pattern of children with chronic pain to a specialized pediatric pain clinic. Data were obtained from referring physicians and medical records and during an interview with patients and their parents by physicians and a psychologist. We analyzed the following: referral diagnosis, demographics, duration of symptoms, number of physicians previously consulted, school attendance, sports activities, presence of psychological disorders, final team diagnosis, and outcomes. Children had been experiencing pain for 34 +/- 55 months. Patients had consulted on average 3 physicians in addition to their pediatrician. 32% of the patients had missed at least 10 days of school in a calendar year, and 47% had stopped playing sports. 15% had an operation because of pain that had been unsuccessful. The most common missed diagnosis was anxiety (25%) and depression (13%). 69% of the patients were back to school and/or playing sports within 4 months from our initial consultation. 32% of the patients did not make any progress during the follow-up period. The most common reasons for failure to improve were no compliance with the recommended treatments and poorly controlled major mood disorder. The time to refer children with chronic pain for specialized care could be extremely long causing significant social and psychological consequence. AN - WOS:000396887000001 AU - Cucchiaro, G. AU - Schwartz, J. AU - Hutchason, A. AU - Ornelas, B. C7 - 8769402 DO - 10.1155/2017/8769402 N1 - Cucchiaro, Giovanni Schwartz, Jennifer Hutchason, Alec Ornelas, Beatriz 1687-9759 PY - 2017 SN - 1687-9740 SP - 1-7 ST - Chronic Pain in Children: A Look at the Referral Process to a Pediatric Pain Clinic T2 - International Journal of Pediatrics TI - Chronic Pain in Children: A Look at the Referral Process to a Pediatric Pain Clinic UR - ://WOS:000396887000001 VL - 2017 ID - 2122 ER - TY - JOUR AB - Pain behaviors are important indicators of functioning in chronic pain; however, no self-reported pain behavior instrument has been developed for pediatric populations. The purpose of this study was to create a brief pediatric measure of patient-reported pain behaviors as part of the Patient-Reported Outcome Measurement Information System (PROMIS). A pool of 47 candidate items for this measure had been previously developed through qualitative research. In this study, youth with chronic pain associated with juvenile fibromyalgia, juvenile idiopathic arthritis, or sickle cell disease (ages 8-18 years) from 3 pediatric centers completed all 47 candidate items for development of the pain behavior item bank along with established measures of pain interference, depressive symptoms, fatigue, average pain intensity, and pain catastrophizing. Caregivers reported on sociodemographic information and health history. Psychometric properties of the pain behavior items were examined using an item response theory framework with confirmatory factor analysis and examination of differential item functioning, internal consistency, and test information curves. Results were used along with expert consensus and alignment with the adult PROMIS pain behavior items to arrive at an 8-item pediatric pain behavior short form, and all 47 items were retained in a calibrated item bank. Confirmatory factor analysis and correlations with validated measures of pain, pain interference, and psychosocial functioning provided support for the short form's reliability and validity. The new PROMIS pediatric pain behavior scale provides a reliable, precise, and valid measure for future research on pain behavior in school-aged children with chronic pain. AD - University of Cincinnati College of Medicine, Cincinnati, OH, USA. Division of Behavioral Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Outcomes Research, Evidera, Bethesda, MD, USA. Department of Pediatrics, Emory University School of Medicine and AFLAC Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA. Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. AN - 28394851 AU - Cunningham, N. R. AU - Kashikar-Zuck, S. AU - Mara, C. AU - Goldschneider, K. R. AU - Revicki, D. A. AU - Dampier, C. AU - Sherry, D. D. AU - Crosby, L. AU - Carle, A. AU - Cook, K. F. AU - Morgan, E. M. C2 - PMC5996986 C6 - NIHMS863544 DA - Jul DO - 10.1097/j.pain.0000000000000914 DP - NLM ET - 2017/04/11 IS - 7 KW - Adolescent Anemia, Sickle Cell/*complications Arthritis, Juvenile/*complications Child Chronic Pain/*diagnosis/etiology Diagnostic Self Evaluation Female Fibromyalgia/*complications Humans Male Pain Measurement/*methods Psychometrics Reproducibility of Results Self Report Severity of Illness Index LA - eng N1 - 1872-6623 Cunningham, Natoshia R Kashikar-Zuck, Susmita Mara, Constance Goldschneider, Kenneth R Revicki, Dennis A Dampier, Carlton Sherry, David D Crosby, Lori Carle, Adam Cook, Karon F Morgan, Esi M U01 AR057929/AR/NIAMS NIH HHS/United States U01 AR052181/AR/NIAMS NIH HHS/United States U01 AR057954/AR/NIAMS NIH HHS/United States U01 AR057940/AR/NIAMS NIH HHS/United States U01 AR057948/AR/NIAMS NIH HHS/United States U01 AR057956/AR/NIAMS NIH HHS/United States U01 AR052158/AR/NIAMS NIH HHS/United States U01 AR057971/AR/NIAMS NIH HHS/United States K24 AR056687/AR/NIAMS NIH HHS/United States U01 AR057967/AR/NIAMS NIH HHS/United States U01 AR052155/AR/NIAMS NIH HHS/United States U54 AR057943/AR/NIAMS NIH HHS/United States U01 AR052171/AR/NIAMS NIH HHS/United States U01 AR057936/AR/NIAMS NIH HHS/United States U01 AR052186/AR/NIAMS NIH HHS/United States U54 AR057951/AR/NIAMS NIH HHS/United States U54 AR057926/AR/NIAMS NIH HHS/United States Journal Article Validation Study Pain. 2017 Jul;158(7):1323-1331. doi: 10.1097/j.pain.0000000000000914. PY - 2017 SN - 0304-3959 (Print) 0304-3959 SP - 1323-1331 ST - Development and validation of the self-reported PROMIS pediatric pain behavior item bank and short form scale T2 - Pain TI - Development and validation of the self-reported PROMIS pediatric pain behavior item bank and short form scale VL - 158 ID - 3131 ER - TY - JOUR AB - Chronic pain (CP) in children is a significant medical condition. The exact incidence is difficult to define but we know that historically it has been underdiagnosed and undertreated. Children can present with a variety of pain conditions (e.g. chronic headache, abdominal pain and musculoskeletal/limb pain). The medical pathway of children with chronic pain is a long and stressful one, often involving extensive investigations. A child with chronic pain will show a variety of concomitant symptoms - sleep disturbance, school absence, psychological symptoms such as anxiety, low mood and in extreme cases depression. The impact on the family needs to be taken into consideration, as by the time the child is referred to pain management there is invariably a degree of parental stress and family dysfunction. Children with chronic pain should have a full assessment of their pain and require the input of a multidisciplinary team: physicians, physiotherapists, psychologists and child and adolescent psychiatrists. Treatment goals rely on reducing or eliminating the pain, improving overall function and allowing the child to develop successful coping strategies. AN - WOS:000214197400001 AU - Cupples, P. A. DA - Dec DO - 10.1016/j.mpaic.2013.09.006 IS - 12 N1 - Cupples, Pamela A. 1878-7584 PY - 2013 SN - 1472-0299 SP - 517-519 ST - Chronic pain in children T2 - Anaesthesia and Intensive Care Medicine TI - Chronic pain in children UR - ://WOS:000214197400001 VL - 14 ID - 2336 ER - TY - JOUR AB - Improvements in hemophilia care over the last several decades might lead to expectations of a near-normal quality of life for young adults with hemophilia. However, few published reports specifically examine health status indicators in this population. To remedy this knowledge gap, we examined the impact of hemophilia on physical and social functioning and quality of life among a national US cohort of 141 young men with hemophilia aged 18-34 years of age who received care at 10 geographically diverse, federally funded hemophilia treatment centers in 11 states between 2005 and 2013 and enrolled in the Hemophilia Utilization Group Studies. Indicators studied included educational achievement, employment status, insurance, health-related quality of life, and prevalence of the following comorbidities: pain, range of motion limitation, overweight/obesity, and viral status. The cohort was analyzed to compare those aged 18-24 to those aged 25-34 years. When compared to the general US adult population, this nationally representative cohort of young US adults with hemophilia experienced significant health and social burdens: more liver disease, joint damage, joint pain, and unemployment as well as lower high-school graduation rates. Nearly half were overweight or obese. Conversely, this cohort had higher levels of health insurance and equivalent mental health scores. While attention has typically focused on newborns, children, adolescents, and increasingly, on older persons with hemophilia, our findings suggest that a specific focus on young adults is warranted to determine the most effective interventions to improve health and functioning for this apparently vulnerable age group. AD - Factor VIII Computing, Berkeley, California. The Center for Comprehensive Care & Diagnosis of Inherited Blood Disorders, Orange, CA and University of California Los Angeles, California. University of Colorado, Hemophilia and Thrombosis Center, Aurora, Colorado. Gulf States Hemophilia & Thrombophilia Center, University of Texas Health Science Center at Houston, Texas. University of Southern California, Los Angeles, California. AN - 26619192 AU - Curtis, R. AU - Baker, J. AU - Riske, B. AU - Ullman, M. AU - Niu, X. AU - Norton, K. AU - Lou, M. AU - Nichol, M. B. DA - Dec DO - 10.1002/ajh.24218 DP - NLM ET - 2015/12/01 KW - Activities of Daily Living Adolescent Adult Age Factors Arthralgia/epidemiology/psychology Chronic Pain/epidemiology/psychology Comorbidity Female Health Surveys Hemophilia A/economics/epidemiology/*psychology/therapy Humans Insurance Coverage/statistics & numerical data Liver Diseases/epidemiology Male Mental Health Overweight/epidemiology Prevalence Prospective Studies *Quality of Life Range of Motion, Articular Socioeconomic Factors Treatment Outcome United States/epidemiology Virus Diseases/epidemiology *Young Adult/psychology LA - eng N1 - 1096-8652 Curtis, Randall Baker, Judith Riske, Brenda Ullman, Megan Niu, Xiaoli Norton, Kristi Lou, Mimi Nichol, Michael B Comparative Study Journal Article Multicenter Study Research Support, Non-U.S. Gov't United States Am J Hematol. 2015 Dec;90 Suppl 2:S11-6. doi: 10.1002/ajh.24218. PY - 2015 SN - 0361-8609 SP - S11-6 ST - Young adults with hemophilia in the U.S.: demographics, comorbidities, and health status T2 - Am J Hematol TI - Young adults with hemophilia in the U.S.: demographics, comorbidities, and health status VL - 90 Suppl 2 ID - 3564 ER - TY - JOUR AB - Case 1: A 33-year-old man with hemoglobin SS (homozygous hemoglobin S) disease presents for his regular clinic visit. He had 6 hospital admissions for pain over the past year. He also has avascular necrosis of the right hip. He takes daily hydroxyurea with hematologic changes indicative of compliance. He also takes morphine sustained release twice daily and morphine immediate release every 6 hours as needed for pain. He feels that more optimal pain control at home would help him reduce his number of hospital admissions in the upcoming year and improve his daily functioning at home. His hematologist decides to use Patient-Reported Outcome Measurement Information System (PROMIS) and Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-ME) to follow changes in the patient's pain. Case 2: An 11-year-old girl with hemoglobin SS disease presents with her mother for her regular clinic visit. She had 2 admissions for pain over the past year. Her mother is concerned because she has been participating less in activities she previously enjoyed and missing classes to go to the school nurse because of pain. She is currently taking hydroxyurea and uses ibuprofen for pain. Her doctor prescribes morphine for home use but wants a way to measure if it is effective in improving her pain. Thus, her physician decides to use PROMIS and the Pediatric Quality of Life Inventory SCD (PedsQL SCD) module to determine the effectiveness of her pain control. AD - Section of Medical Oncology/Hematology Yale Cancer Center, New Haven, CT. Section of Pediatric Hematology/Oncology Medical College of Wisconsin, Milwaukee, WI; and. Children's Research Institute of the Children's Hospital of Wisconsin, Milwaukee, WI. AN - 29222303 AU - Curtis, S. AU - Brandow, A. M. C2 - PMC6142574 DA - Dec 8 DO - 10.1182/asheducation-2017.1.542 DP - NLM ET - 2017/12/10 IS - 1 KW - Adult Anemia, Sickle Cell/*therapy Child Female *Health Information Systems Humans Male Morphine/administration & dosage/adverse effects *Pain Management *Pain Measurement LA - eng N1 - 1520-4383 Curtis, Susanna Brandow, Amanda M K23 HL114636/HL/NHLBI NIH HHS/United States Case Reports Journal Article Review Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):542-545. doi: 10.1182/asheducation-2017.1.542. PY - 2017 SN - 1520-4391 (Print) 1520-4383 SP - 542-545 ST - Responsiveness of Patient-Reported Outcome Measurement Information System (PROMIS) pain domains and disease-specific patient-reported outcome measures in children and adults with sickle cell disease T2 - Hematology Am Soc Hematol Educ Program TI - Responsiveness of Patient-Reported Outcome Measurement Information System (PROMIS) pain domains and disease-specific patient-reported outcome measures in children and adults with sickle cell disease VL - 2017 ID - 3678 ER - TY - JOUR AB - CONTEXT: There are no studies on the effect of volunteer-provided hand massage in a busy chemotherapy outpatient practice. OBJECTIVE: To assess the feasibility of introducing hand massage therapy into an outpatient chemotherapy unit and to evaluate the effect of the therapy on various symptoms experienced by cancer patients. DESIGN: A pilot, quasi-experimental, pretest-posttest study. SETTING: Chemotherapy outpatient clinic of a large tertiary care academic medical center. PATIENTS/PARTICIPANTS: Forty chemotherapy outpatients. INTERVENTION: After being approached by a trained volunteer from a hand massage team, patients consented to receive a 20-minute hand massage before chemotherapy that was individualized according to patient preference and expressed needs. MAIN OUTCOME MEASURES: The visual analog scale (VAS) was used to measure pain, fatigue, anxiety, muscular discomfort, nervousness, stress, happiness, energy, relaxation, calmness, and emotional well-being (on a scale from 0-10) before and after the intervention; a satisfaction survey was administered after the therapy. Patients' demographic data were summarized with descriptive statistics, and VAS total scores were compared between groups at each time point with the two-group t test. Feasibility was evaluated from the number of patients who were approached, received a hand massage, and completed the study surveys. RESULTS: Of the 40 participants, 19 were men (mean age, 59.5 years). Significant improvement after hand massage was indicated by VAS scores for fatigue, anxiety, muscular discomfort, nervousness, stress, happiness, energy, relaxation, calmness, and emotional well-being (P < .05). Pain scores also improved, but the difference was not statistically significant (P = .06). All patients indicated that they would recommend hand massage to other patients, and 37 were interested in receiving it during their next chemotherapy treatment. AD - Division of General Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address: cutshall.susanne@mayo.edu. Division of General Internal Medicine, Mayo Clinic, Rochester, MN. Hospital Operations, Mayo Clinic, Rochester, MN. Department of Nursing, Mayo Clinic, Rochester, MN. Department of Emergency Medicine, Mayo Clinic, Owatonna, MN. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN. AN - 29097109 AU - Cutshall, S. M. AU - Mahapatra, S. AU - Hynes, R. S. AU - Van Rooy, K. M. AU - Looker, S. A. AU - Ghosh, A. AU - Schleck, C. D. AU - Bauer, B. A. AU - Wahner-Roedler, D. L. DA - Nov-Dec DO - 10.1016/j.explore.2017.06.007 DP - NLM ET - 2017/11/04 IS - 6 KW - Adolescent Adult Aged *Ambulatory Care Anxiety/etiology/therapy Emotions Fatigue/etiology/therapy Feasibility Studies Female *Hand Humans Male *Massage Middle Aged Muscles *Neoplasms/complications/drug therapy/psychology Pain Management *Patient Satisfaction Pilot Projects Relaxation Stress, Psychological/etiology/therapy Surveys and Questionnaires Young Adult Cancer Chemotherapy Hand massage Volunteers LA - eng N1 - 1878-7541 Cutshall, Susanne M Mahapatra, Saswati Hynes, Rebecca S Van Rooy, Kimberly M Looker, Sherry A Ghosh, Aditya Schleck, Cathy D Bauer, Brent A Wahner-Roedler, Dietlind L Journal Article United States Explore (NY). 2017 Nov-Dec;13(6):393-399. doi: 10.1016/j.explore.2017.06.007. Epub 2017 Aug 25. PY - 2017 SN - 1550-8307 SP - 393-399 ST - Hand Massage for Cancer Patients Undergoing Chemotherapy as Outpatients: A Pilot Study T2 - Explore (NY) TI - Hand Massage for Cancer Patients Undergoing Chemotherapy as Outpatients: A Pilot Study VL - 13 ID - 3823 ER - TY - JOUR AB - Chronic daily headache (CDH) affects 2 to 4% of adolescent females and 0.8 to 2% of adolescent males. Chronic daily headache is diagnosed when headaches occur more than 4 hours a day, for greater than or equal to 15 headache days per month, over a period of 3 consecutive months, without an underlying pathology. It is manifested by severe intermittent headaches, that are migraine-like, as well as a chronic baseline headache. Silberstein and Lipton divided patients into four diagnostic categories: transformed migraine, chronic tension-type headache, new daily-persistent headache, and hemicrania continua. The second edition of the International Classification of Headache Disorders did not comprise any CDH category as such, but provided criteria for all four types of CDH: chronic migraine, chronic tension- type headache, new daily-persistent headache, and hemicrania continua. The International Headache Society. Children and adolescents with chronic daily headache frequently have sleep disturbance, pain at other sites, dizziness, medication-overuse headache and a psychiatric comorbidity (anxiety and mood disorders). Chronic daily headache frequently results in school absence. Successful approaches to treatment include reassurance, education, use of preventative medication, avoidance of analgesics, and helping the child work its way back into a functional daily routine and a regular school schedule. AN - WOS:000433875100003 AU - Cuvellier, J. C. DO - 10.2174/157339608787407636 IS - 4 N1 - Cuvellier, Jean-Christophe 1875-6336 PY - 2008 SN - 1573-3963 SP - 233-242 ST - Pediatric Chronic Daily Headache T2 - Current Pediatric Reviews TI - Pediatric Chronic Daily Headache UR - ://WOS:000433875100003 VL - 4 ID - 2667 ER - TY - JOUR AB - Chronic daily headache (CDH) affects 2-4% of adolescent females and 0.8-2% of adolescent males. Chronic daily headache is diagnosed when headaches occur more than 4 h/day, 15 headache days per month or more, over a period of 3 consecutive months, without an underlying pathology. It is manifested by severe intermittent, migraine-like headaches as well as by chronic baseline headaches. Both Silberstein-Lipton criteria and the second edition of the International Classification of Headache Disorders (ICHD) can be used to classify chronic daily headache in children and adolescents. Chronic daily headache is' classified into four diagnostic categories: transformed (Silberstein-Lipton criteria)/chronic (ICHD) migraine, chronic tension-type headache, new daily persistent headache, and hemicrania continua. Children and adolescents with chronic daily headache frequently have sleep disturbance, pain at other sites, dizziness, medication-overuse headache, and a psychiatric comorbidity (anxiety and mood disorders). Chronic daily headache frequently results in school absence. Successful approaches to treatment include reassurance, education, use of preventative medication, avoidance of analgesics; and helping the child return to a functional daily routine and a regular school schedule. (C) 2008 Elsevier Masson SAS. All rights reserved. AN - WOS:000261772400012 AU - Cuvellier, J. C. AU - Cuisset, J. M. AU - Vallee, L. DA - Dec DO - 10.1016/j.arcped.2008.09.017 IS - 12 N1 - Cuvellier, J. -C. Cuisset, J. -M. Vallee, L. 1769-664x PY - 2008 SN - 0929-693X SP - 1805-1814 ST - Chronic daily headache in children and adolescents T2 - Archives De Pediatrie TI - Chronic daily headache in children and adolescents UR - ://WOS:000261772400012 VL - 15 ID - 2630 ER - TY - JOUR AB - BACKGROUND: Isotretinoin, for acne treatment, is associated with high rates of permanent remission. However, at recommended doses of 0.5-1.0 mg/kg/day for 5-6 months [average cumulative dose: 120-150 mg/kg], more than 20% of patients experience a relapse within two years that requires further medical management. OBJECTIVE: To examine outcomes of high-dose isotretinoin in a cohort with cystic acne, as well as measuring its impact on quality of life (QOL). METHODS: A single dermatologist, single institution investigation within an academic tertiary care center in Bronx, NY. Eighty patients with nodulocystic acne, maintained on oral isotretinoin at a dose of 1.3 mg/kg/day or greater, were studied from 2006-2009 while additionally participating in a QOL survey. Main outcome measures included documented events, acne clearance, presence of relapse, and quality of life parameters. RESULTS: The mean daily dose of isotretinoin was 1.6 mg/kg/day for an average time course of 178 days [cumulative dose: 290 mg/kg]. No side effects or laboratory abnormalities led to discontinuation of treatment. There were no psychiatric symptoms. One-hundred percent (100%) of patients were disease-free upon completion of treatment. During the three-year study period, 10 patients (12.5%) developed a relapse that required an additional course of isotretinoin. Analysis of QOL domains (self-perception, role-social, symptoms) revealed significant improvement following isotretinoin therapy (p = 0.0124, p = 0.0066, p = 0.0265, respectively). CONCLUSIONS: Isotretinoin prescribed at 1.5 mg/kg/day or greater for 5-6 months [cumulative total dose of 290 mg/kg] is safe and effective compared to current standard dosing practices. We propose the use of high-dose isotretinoin (>1.3 mg/kg/day) as a treatment option in severe nodulocystic acne and encourage larger, prospective, multicenter studies into this therapeutic approach. AD - Department of Dermatology, Albert Einstein College of Medicine, New York, NY 10467, USA. AN - 22909370 AU - Cyrulnik, A. A. AU - Viola, K. V. AU - Gewirtzman, A. J. AU - Cohen, S. R. DA - Sep DO - 10.1111/j.1365-4632.2011.05409.x DP - NLM ET - 2012/08/23 IS - 9 KW - Acne Vulgaris/*drug therapy/psychology Adolescent Adult Child Dermatologic Agents/*administration & dosage/adverse effects Female Headache/chemically induced Health Surveys Humans Isotretinoin/*administration & dosage/adverse effects Liver Function Tests Male Middle Aged Musculoskeletal Pain/chemically induced Quality of Life/*psychology Recurrence Retrospective Studies Self Concept Surveys and Questionnaires Treatment Outcome Young Adult LA - eng N1 - 1365-4632 Cyrulnik, Amanda A Viola, Kate V Gewirtzman, Aron J Cohen, Steven R Journal Article England Int J Dermatol. 2012 Sep;51(9):1123-30. doi: 10.1111/j.1365-4632.2011.05409.x. PY - 2012 SN - 0011-9059 SP - 1123-30 ST - High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life T2 - Int J Dermatol TI - High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life VL - 51 ID - 3367 ER - TY - JOUR AB - Purpose: The specific assessment of pain and quality of life in children with sickle cell anemia (SCA) is still the subject of few studies and is traditionally evaluated through perception of their parents or guardians. Thus, this study aimed to evaluate pain, its characteristics, and impact on the quality of life (QoL) in children diagnosed with SCA, valuing their self-report. Patients and Methods: This study was conducted on hematology and hemotherapy outpatient clinic in Sao Luis, Brazil, with children between 7 years and 12 years with SCA, of both genders. The instruments used were Numeric Pain Rating Scale, Faces Pain Scale and Autoquestionnaire Qualite de Vie Enfante Image (AUQEI) for the assessment of pain and QoL from the children's self-report. The association between pain intensity and QoL was verified through the Chi-square test and the relationship between pain and the domains of AUQEI was verified through Pearson's correlation, using Stata 10.0 (R). Results: The sample consisted of 104 children with a mean age of 8.97 years, 51.9% were male and 94.2% non-white. Pain was characterized predominately moderate to strong, stabbing (37.5%) and burning (31.7%), with greater frequency in the limbs, and reported simultaneously in two or more locations. The average pain score was 9.26 at the worst time and in the general context was 6.02. As a result of pain, 93.3% reported school absence, averaging 8.57 days of absence; 63.5% had sleep disturbance and 86.5% failed to perform your daily activities. QoL results were negative in 48.08% and 56.25% of these had severe pain. About 74% of children with positive QoL had mild pain. Conclusion: Pain in children with SCA has a negative impact on their QoL based on their point of view, affecting their daily life. These findings highlight the importance of valuing children's self-report of the disease, especially in a restricted resource scenario. AN - WOS:000600938800001 AU - da Cunha, V. B. AU - Rodrigues, C. F. D. AU - Rodrigues, T. A. AU - de Oliveira, Ejsg AU - Garcia, J. B. S. DO - 10.2147/jpr.S261605 N1 - da Cunha, Valeska Brito de Andrade Rodrigues, Camila Freitas Rodrigues, Thiago Alves Silva Gomes de Oliveira, Eduardo Jose Santos Garcia, Joao Batista PY - 2020 SN - 1178-7090 SP - 3171-3180 ST - Self-Report for Assessment of Pain and Quality of Life in Children with Sickle Cell Anemia in a Developing Country T2 - Journal of Pain Research TI - Self-Report for Assessment of Pain and Quality of Life in Children with Sickle Cell Anemia in a Developing Country UR - ://WOS:000600938800001 VL - 13 ID - 1852 ER - TY - JOUR AB - Background Research among adult and paediatric samples suggests that pain-related injustice appraisals contribute to adverse pain-related functioning. However, a singular focus on pain-related injustice appraisals carries the risk of underestimating the role of broader concepts of justice. This study examined the unique roles of child pain-related injustice appraisals and just-world beliefs in understanding disability and physical, emotional, social and academic functioning, as well as the mediating role of injustice appraisals in the relationship between just-world beliefs and functioning. Methods Participants comprised a school sample of 2,174 children (Study 1) and a clinical sample of 146 paediatric chronic pain patients (Study 2) who completed the Injustice Experience Questionnaire (IEQ), Personal and General Belief in a Just World scales (JWB-P/G), Functional Disability Inventory (FDI), Pain Catastrophizing Scale for Children (PCS-C) and Pediatric Quality of Life Inventory (PEDSQL). Results For both samples, child pain-related injustice appraisals were associated with poorer functioning, after controlling for just-world beliefs, catastrophizing, pain intensity, age and sex. In the school sample, injustice appraisals mediated the associations of both personal and general just-world beliefs with functioning. In the clinical sample, injustice appraisals mediated the association of personal, but not general, just-world beliefs with all functioning scales. Conclusions The current findings attest to the unique role of pain-related injustice appraisals in understanding child pain-related functioning and their explanatory value in understanding the relationship between fundamental just-world beliefs and child pain-related functioning. Significance The present study adds to emerging literature on the adverse effects of child pain-related injustice appraisals in the context of pain, through showing that pain-related injustice appraisals are uniquely associated with pain-related functioning and mediate the relationship between just-world beliefs and pain-related functioning. These findings suggest that interventions may target pain-related injustice appraisals as a mechanism for change in children. AN - WOS:000597553900001 AU - Daenen, F. AU - McParland, J. AU - Baert, F. AU - Miller, M. M. AU - Hirsh, A. T. AU - Vervoort, T. DO - 10.1002/ejp.1707 N1 - Daenen, Frederick McParland, Joanna Baert, Fleur Miller, Megan Marie Hirsh, Adam Todd Vervoort, Tine Daenen, Frederick/0000-0002-0657-5468; McParland, Jo/0000-0003-0580-2179 1532-2149 SN - 1090-3801 ST - Child pain-related injustice appraisals mediate the relationship between just-world beliefs and pain-related functioning T2 - European Journal of Pain TI - Child pain-related injustice appraisals mediate the relationship between just-world beliefs and pain-related functioning UR - ://WOS:000597553900001 ID - 1779 ER - TY - JOUR AB - BACKGROUND: Research among adult and paediatric samples suggests that pain-related injustice appraisals contribute to adverse pain-related functioning. However, a singular focus on pain-related injustice appraisals carries the risk of underestimating the role of broader concepts of justice. This study examined the unique roles of child pain-related injustice appraisals and just-world beliefs in understanding disability and physical, emotional, social and academic functioning, as well as the mediating role of injustice appraisals in the relationship between just-world beliefs and functioning. METHODS: Participants comprised a school sample of 2,174 children (Study 1) and a clinical sample of 146 paediatric chronic pain patients (Study 2) who completed the Injustice Experience Questionnaire (IEQ), Personal and General Belief in a Just World scales (JWB-P/G), Functional Disability Inventory (FDI), Pain Catastrophizing Scale for Children (PCS-C) and Pediatric Quality of Life Inventory (PEDSQL). RESULTS: For both samples, child pain-related injustice appraisals were associated with poorer functioning, after controlling for just-world beliefs, catastrophizing, pain intensity, age and sex. In the school sample, injustice appraisals mediated the associations of both personal and general just-world beliefs with functioning. In the clinical sample, injustice appraisals mediated the association of personal, but not general, just-world beliefs with all functioning scales. CONCLUSIONS: The current findings attest to the unique role of pain-related injustice appraisals in understanding child pain-related functioning and their explanatory value in understanding the relationship between fundamental just-world beliefs and child pain-related functioning. SIGNIFICANCE: The present study adds to emerging literature on the adverse effects of child pain-related injustice appraisals in the context of pain, through showing that pain-related injustice appraisals are uniquely associated with pain-related functioning and mediate the relationship between just-world beliefs and pain-related functioning. These findings suggest that interventions may target pain-related injustice appraisals as a mechanism for change in children. AD - Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium. Department of Psychology, Glasgow Caledonian University, Glasgow, UK. Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA. AN - 33259693 AU - Daenen, F. AU - McParland, J. AU - Baert, F. AU - Miller, M. M. AU - Hirsh, A. T. AU - Vervoort, T. DA - Apr DO - 10.1002/ejp.1707 DP - NLM ET - 2020/12/02 IS - 4 KW - Adult Catastrophization Child *Chronic Pain Humans Pain Measurement Pain Perception *Quality of Life Surveys and Questionnaires LA - eng N1 - 1532-2149 Daenen, Frederick McParland, Joanna Baert, Fleur Miller, Megan Marie Hirsh, Adam Todd Vervoort, Tine Journal Article Research Support, Non-U.S. Gov't England Eur J Pain. 2021 Apr;25(4):757-773. doi: 10.1002/ejp.1707. Epub 2020 Dec 11. PY - 2021 SN - 1090-3801 SP - 757-773 ST - Child pain-related injustice appraisals mediate the relationship between just-world beliefs and pain-related functioning T2 - Eur J Pain TI - Child pain-related injustice appraisals mediate the relationship between just-world beliefs and pain-related functioning VL - 25 ID - 3002 ER - TY - JOUR AB - Juvenile fibromyalgia (JFM) is a chronic and debilitating noninflammatory musculoskeletal pain syndrome that is typically diagnosed in adolescence. There are no specific medical tests or disease markers to diagnose the condition, and classification is based on patient report of pain and other associated symptoms after ruling out other underlying medical causes. JFM can be disabling in multiple life domains and therefore, a multidimensional assessment of JFM is recommended to gain a full picture of the extent of JFM symptoms along with their impact on physical and emotional functioning and quality of life. The following updated review outlines evidence-based measures useful in the assessment of school-age children and adolescents with JFM. New measures include 1) the Pain and Symptom Assessment Tool (PSAT) that offers a standardized tool for the classification of fibromyalgia in pediatric patients and 2) the Patient-Reported Outcomes Measurement Information System (PROMIS®) Pediatric Pain Interference, Anxiety, and Depression Scales. Updated information is presented on previously established measures that assess the impact of JFM on functioning and quality of life - the Functional Disability Inventory (FDI) and the Pediatric Quality of Life Inventory (PedsQL) 3.0 Rheumatology Module Pain and Hurt Scale, are also discussed. In general, there are increasing options for validated patient-reported outcome measures available to measure the spectrum of symptoms in JFM and assess impact on daily life. Greater consistency in identification of JFM and use of standardized assessment tools will undoubtedly lead to higher quality research much needed in this relatively understudied musculoskeletal pain condition. AD - Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. University of Cincinnati, Cincinnati, Ohio. AN - 33091238 AU - Daffin, M. AU - Gibler, R. C. AU - Kashikar-Zuck, S. C2 - PMC7647372 C6 - NIHMS1589500 interest. R.C. Gibler declares that he has no conflict of interest. S. Kashikar-Zuck declares that she has no conflict of interest. DA - Oct DO - 10.1002/acr.24197 DP - NLM ET - 2020/10/23 IS - Suppl 10 KW - Adolescent Child *Fibromyalgia Humans *Outcome Assessment, Health Care Psychometrics/instrumentation Severity of Illness Index LA - eng N1 - 2151-4658 Daffin, Morgan Gibler, Robert C Kashikar-Zuck, Susmita K24 AR056687/AR/NIAMS NIH HHS/United States Journal Article Review Arthritis Care Res (Hoboken). 2020 Oct;72 Suppl 10(Suppl 10):171-182. doi: 10.1002/acr.24197. PY - 2020 SN - 2151-464X (Print) 2151-464x SP - 171-182 ST - Measures of Juvenile Fibromyalgia T2 - Arthritis Care Res (Hoboken) TI - Measures of Juvenile Fibromyalgia VL - 72 Suppl 10 ID - 2985 ER - TY - JOUR AB - BACKGROUND: Children dental pain recognition is pointed as a priority in paediatric dentistry, but little is known about dentists' perception of pre-schoolers' dental pain. AIM: To understand paediatric dentists' viewpoint on dental pain (toothache) in pre-schoolers and to identify the associated factors. DESIGN: Mixed-methods with two phases: (i) preliminary qualitative study (focus group of paediatric dentists), with responses analysed by content analysis and (ii) quantitative survey (self-administered questionnaire answered by 223 paediatric dentists), with the main outcome 'perception' assessed as 'feel or not prepared' to identify a pre-schooler with dental pain. Triangulation was used to discuss the results of each approach. RESULTS: (i) Paediatric dentists can observe dental pain in pre-schoolers when there are normative signs; this pain is related to the changes in a child's behaviour and in dental planning. (ii) Participants were 40.1 ± 8.4 years old, 17.1 ± 8.3years since graduation, 65.9% did not feel prepared to identify a pre-schooler with dental pain. This feeling of unpreparedness was associated with younger specialists (P = 0.01) and less time since graduation (P < 0.01). Triangulation showed a convergence of the qualitative and quantitative approaches. CONCLUSION: Noticing dental pain in pre-schoolers was associated with specialists' experience and the need for visible signs; dentists do not always feel completely prepared to recognise pain in pre-schoolers. AD - Health Sciences Graduate Program, Federal University of Goias (UFG), Goiania, Brazil. AN - 24612101 AU - Daher, A. AU - Costa, M. AU - Costa, L. R. DA - Jan DO - 10.1111/ipd.12099 DP - NLM ET - 2014/03/13 IS - 1 KW - Adult *Attitude of Health Personnel Child, Preschool Dental Care for Children *Dentist-Patient Relations Dentists/*psychology Female Focus Groups Humans Male *Pain Management *Pain Measurement Surveys and Questionnaires *Toothache LA - eng N1 - 1365-263x Daher, Anelise Costa, Márcia Costa, Luciane R Journal Article Research Support, Non-U.S. Gov't England Int J Paediatr Dent. 2015 Jan;25(1):51-60. doi: 10.1111/ipd.12099. Epub 2014 Feb 24. PY - 2015 SN - 0960-7439 SP - 51-60 ST - Factors associated with paediatric dentists' perception of dental pain in pre-schoolers: a mixed-methods study T2 - Int J Paediatr Dent TI - Factors associated with paediatric dentists' perception of dental pain in pre-schoolers: a mixed-methods study VL - 25 ID - 3739 ER - TY - JOUR AB - Objectives: To develop a profile of impairment and activity limitation among children with epiphyseal dysplasia (ED) and to identify the relationship between these 2 domains. Design: Cross-sectional study. Setting: Acute, pediatric academic and health sciences center. Participants: Eleven subjects with multiple epiphyseal dysplasia (MED) and 17 subjects with spondyloepiphyseal dysplasia (SED), with a mean age of 12.9 years. Interventions: Not applicable. Main Outcome Measures: Anthropometric indexes of growth and nutrition, joint range of motion (ROM) and alignment, muscle strength, pain, and activity limitation. Results: Subjects with SED had significantly shorter stature than the reference population (P<.01). Seventy-three percent of participants with MED and 77% of those with SED were above average or overweight for their height (P<.01). Both groups presented with moderate to severe joint ROM impairment, with greater lower-extremity involvement. Subjects with SED had worse outcomes with respect to overall ROM and alignment impairments (P<.01), particularly in their upper extremities (P<.01), than subjects with MED. Significant overall muscle weakness was noted in all subjects (z=-1.81; P<.01). Ninety-four percent of subjects with SED reported pain with activity, compared with 64% of those with MED (P=.04), although pain intensity did not differ between groups. Fifty percent of subjects had undergone orthopedic surgery. Mild activity limitation was reported by all subjects (mean score, 87.7+/-18.83). Significant correlations were identified between height for age and strength (r=.50) and pain and activity limitation (r=-.50). Conclusions: Despite moderate to severe impairments, all subjects reported surprisingly mild activity limitation. A positive correlation was identified between pain and activity limitation. This study also identified and described patterns of muscle weakness, pain, and nutritional concerns not previously reported in the ED literature. (C) 2004 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. AN - WOS:000224404700013 AU - Damignani, R. AU - Young, N. L. AU - Cole, W. G. AU - Anthony, A. M. AU - Badley, E. M. DA - Oct DO - 10.1016/j.apmr.2003.12.030 IS - 10 N1 - Damignani, R Young, NL Cole, WG Anthony, AM Badley, EM 5th Interdisciplinary Paediatric Orthopaedic Conference Apr 12, 2002 Montreal, CANADA ; Young, Nancy/G-3934-2011 Anthony, Alison/0000-0002-6085-699X; Young, Nancy/0000-0002-1739-3299 1532-821x PY - 2004 SN - 0003-9993 SP - 1647-1652 ST - Impairment and activity limitation associated with epiphyseal dysplasia in children T2 - Archives of Physical Medicine and Rehabilitation TI - Impairment and activity limitation associated with epiphyseal dysplasia in children UR - ://WOS:000224404700013 VL - 85 ID - 2783 ER - TY - JOUR AB - PURPOSE: To determine the incidence of pain and the types of home pain management techniques used by children and adolescents with sickle cell disease (SCD) and their caregivers. PATIENTS AND METHODS: Thirty-seven children and adolescents (ages 6-21 years) with SCD used a self-report pain diary twice daily to report their pain experience and its management for 6 months to 3 years. A total of 18,377 diary days representing 514 distinct pain episodes were analyzed. RESULTS: Pain related to SCD was reported on 2592 days and 2326 nights, with analgesic medication taken on 88% of days and 76% of nights. A single oral analgesic was used on 58% of these days. On the remaining days, multiple analgesics were used in a variety of combinations. More frequent analgesic dosing was reported on days with more intense pain. Pain relief was substantially better for analgesic combinations than for single analgesics, particularly for moderate to severe pain. CONCLUSIONS: Pain went untreated on a modest number of days, and many patients relied on relatively ineffective single analgesics. Other patients and families appropriately used potent analgesic combinations in a time-contingent and intensity-dependent pattern. This study suggests that recurrent acute pain from SCD can be successfully managed at home with appropriate training and supervision, and suggests several areas for intervention to improve patient outcomes. AD - Marian Anderson Comprehensive Sickle Cell Center, St. Christopher's Hospital for Children, Erie Avenue at Front Street, Philadelphia, PA 19134-1095, USA. Carlton.Dampier@drexel.edu AN - 12439036 AU - Dampier, C. AU - Ely, E. AU - Brodecki, D. AU - O'Neal, P. DA - Nov DO - 10.1097/00043426-200211000-00008 DP - NLM ET - 2002/11/20 IS - 8 KW - Absenteeism Adolescent Adult Analgesics, Non-Narcotic/administration & dosage/therapeutic use Anemia, Sickle Cell/*complications/therapy Biomarkers Child Child, Preschool Drug Administration Schedule Drug Therapy, Combination Female Home Nursing Humans Hydroxyurea/therapeutic use Longitudinal Studies Male *Medical Records Narcotics/administration & dosage/therapeutic use Pain/*epidemiology/etiology Pain Management Pain Measurement Quality of Life Reproducibility of Results Sickle Cell Trait/complications LA - eng N1 - Dampier, Carlton Ely, Elizabeth Brodecki, Darcy O'Neal, Patricia HL 51496/HL/NHLBI NIH HHS/United States HL 51495/HL/NHLBI NIH HHS/United States P60 HL 62148/HL/NHLBI NIH HHS/United States HL 51497/HL/NHLBI NIH HHS/United States Journal Article Research Support, U.S. Gov't, P.H.S. United States J Pediatr Hematol Oncol. 2002 Nov;24(8):643-7. doi: 10.1097/00043426-200211000-00008. PY - 2002 SN - 1077-4114 (Print) 1077-4114 SP - 643-7 ST - Home management of pain in sickle cell disease: a daily diary study in children and adolescents T2 - J Pediatr Hematol Oncol TI - Home management of pain in sickle cell disease: a daily diary study in children and adolescents VL - 24 ID - 3516 ER - TY - JOUR AB - Background The hallmark of sickle cell disease (SCD) is pain from a vaso-occlusive crisis. Although ambulatory pain accounts for most days in pain, pain is also the most common cause of hospitalization and is typically treated with parenteral opioids. The evidence base is lacking for most analgesic practice in SCD, particularly for the optimal opioid dosing for patient-controlled analgesia (PCA), in part because of the challenges of the trial design and conduct for this rare disease. Purpose The purpose of this report is to describe our Network's experiences with protocol development, implementation, and analysis, including overall study design, the value of pain assessments rather than 'crisis' resolution as trial endpoints, and alternative statistical analysis strategies. Methods The Improving Pain Management and Outcomes with Various Strategies (IMPROVE) PCA trial was a multisite inpatient randomized controlled trial comparing two PCA-dosing strategies in adults and children with SCD and acute pain conducted by the SCD Clinical Research Network. The specified primary endpoint was a 25-mm change in a daily average pain intensity using a Visual Analogue Scale, and a number of related pain intensity and pain interference measures were selected as secondary efficacy outcomes. A time-to-event analysis strategy was planned for the primary endpoint. Results 01 1116 individuals admitted for pain at 31 participating sites over a 6-month period, 38 were randomized and 4 withdrawn. The trial was closed early due to poor accrual, reflecting a substantial number of challenges encountered during trial implementation. Limitations While some of the design issues were unique to SCD or analgesic studies, many of the trial implementation challenges reflected the increasing complexity of conducting clinical trials in the inpatient setting with multiple care providers and evolving electronic medical record systems, particularly in the context of large urban academic medical centers. Lessons learned Complicated clinical organization of many sites likely slowed study initiation. More extensive involvement of research staff and site principal investigator in the clinical care operations improved site performance. During the subsequent data analysis, alternative statistical approaches were considered, the results of which should inform future efficacy assessments and increase future trial recruitment success by allowing substantial reductions in target sample size. Conclusions A complex randomized analgesic trial was initiated within a multisite disease network seeking to provide an evidence base for clinical care. A number of design considerations were shown to be feasible in this setting, and several pain intensity and pain interference measures were shown to be sensitive to time- and treatment-related improvements. While the premature closure and small sample size precluded definitive conclusions regarding treatment efficacy, this trial furnishes a template for design and implementation considerations that should improve future SCD analgesic trials. Clinical Trials 2013; 10: 319-331. http://ctj.sagepub.com AN - WOS:000318263300013 AU - Dampier, C. D. AU - Smith, W. R. AU - Wager, C. G. AU - Kim, H. Y. AU - Bell, M. C. AU - Miller, S. T. AU - Weiner, D. L. AU - Minniti, C. P. AU - Krishnamurti, L. AU - Ataga, K. I. AU - Eckman, J. R. AU - Hsu, L. L. AU - McClish, D. AU - McKinlay, S. M. AU - Molokie, R. AU - Osunkwo, I. AU - Smith-Whitley, K. AU - Telen, M. J. AU - Scdcrn DA - Apr DO - 10.1177/1740774513475850 IS - 2 N1 - Dampier, Carlton D. Smith, Wally R. Wager, Carrie G. Kim, Hae-Young Bell, Margaret C. Miller, Scott T. Weiner, Debra L. Minniti, Caterina P. Krishnamurti, Lakshmanan Ataga, Kenneth I. Eckman, James R. Hsu, Lewis L. McClish, Donna McKinlay, Sonja M. Molokie, Robert Osunkwo, Ifeyinwa Smith-Whitley, Kim Telen, Marilyn J. Osunkwo, Ifeyinwa/AAT-9315-2020; Dampier, Carlton/Q-2967-2019; Hsu, Lewis L/H-8001-2019 Dampier, Carlton/0000-0002-7738-2620; Telen, Marilyn/0000-0003-3809-1780; Hsu, Lewis/0000-0002-3156-2378 1740-7753 PY - 2013 SN - 1740-7745 SP - 319-331 ST - IMPROVE trial: A randomized controlled trial of patient-controlled analgesia for sickle cell painful episodes: rationale, design challenges, initial experience, and recommendations for future studies T2 - Clinical Trials TI - IMPROVE trial: A randomized controlled trial of patient-controlled analgesia for sickle cell painful episodes: rationale, design challenges, initial experience, and recommendations for future studies UR - ://WOS:000318263300013 VL - 10 ID - 2372 ER - TY - JOUR AB - BACKGROUND: Acute pain in hospitalized pediatric patients is prevalent. Recent shifts in the paradigm of pediatric acute pain management focus less on reliance on opioids, due to their adverse side effects and risk of dependence, and more on multimodal pain management. OBJECTIVE: We sought to review the most recent studies on acute pain management in hospitalized pediatric patients. METHOD: We searched the Cochrane Database and PubMed for articles published in the past five years regarding the treatment of acute pain in pediatric patients focusing on large randomized or quasirandomized controlled trials, cohort trials, and meta-analyses. RESULTS: We categorized results into non-pharmacological, localized, non-opiate pharmacological, and opiate based therapies. Recent studies show that environmental and non-pharmacological methods of pain management are efficacious in infants. School aged children benefit from active distraction more than passive distraction. Needleless methods of introducing lidocaine locally alleviate the pain associated with many procedures to which hospitalized children are exposed. The shift towards use of nonopiate pharmacology focuses on novel means of utilizing older medications, such as intravenous parecoxib, inhaled methoxyflurane, and sublingual ketorolac or tramadol and the avoidance of codeine. CONCLUSION: Acute pediatric pain management has changed to emphasize multimodal and multidisciplinary therapy. In all children, non-pharmacological therapies should be employed routinely. Given the myriad tools available, pediatric acute pain services have developed in order to integrate more advanced treatments such as nerve blocks and infusions of centrally acting pain modulators. AD - Department of Medicine and Pediatrics, University of North Carolina, 101 Manning Drive, Campus Box 7085, Chapel Hill, NC, 27599-7085. United States. Department of Internal Medicine and Pediatrics, University of North Carolina, Chapel Hill, NC. United States. Department of Pediatrics, University of California, San Francisco, CA. United States. AN - 28814263 AU - Dancel, R. AU - Liles, E. A. AU - Fiore, D. DO - 10.2174/1574887112666170816151232 DP - NLM ET - 2017/08/18 IS - 4 KW - Acute Pain/*therapy Child Humans *Inpatients Pain Management/*methods *Acute pain *analgesia *hospital *meta-analyses *multi-modal treatment *pediatric LA - eng N1 - 1876-1038 Dancel, Ria Liles, Edmund Allen Fiore, Darren Journal Article Review United Arab Emirates Rev Recent Clin Trials. 2017;12(4):277-283. doi: 10.2174/1574887112666170816151232. PY - 2017 SN - 1574-8871 SP - 277-283 ST - Acute Pain Management in Hospitalized Children T2 - Rev Recent Clin Trials TI - Acute Pain Management in Hospitalized Children VL - 12 ID - 2962 ER - TY - JOUR AB - ObjectiveaEuro integral Tested a family-based group problem-solving intervention, "Families Taking Control," (FTC) to improve school functioning and health-related quality of life (HRQL) for children with sickle cell disease.aEuro integral MethodaEuro integral Children and caregivers completed questionnaires assessing HRQL and school functioning and children completed performance-based measures of IQ and achievement at baseline and 6 months later. Families were randomized to the intervention (FTC, n = 42) or delayed intervention control (DIC, n = 41) group. FTC involved a full-day workshop followed by 3 booster calls.aEuro integral ResultsaEuro integral There were no differences between FTC completers (n = 24) and noncompleters (n = 18). FTC group (n = 24) and DIC group (n = 38) did not differ significantly on primary outcomes at follow-up: number of formal academic and disease-related accommodations, individualized education plan/504 service plan, school absences, school HRQL, or academic skills.aEuro integral ConclusionsaEuro integral Although families found FTC to be acceptable, there were no intervention effects. Challenges of the trial and implications for future research are discussed. AN - WOS:000364771600011 AU - Daniel, L. C. AU - Li, Y. M. AU - Smith, K. AU - Tarazi, R. AU - Robinson, M. R. AU - Patterson, C. A. AU - Smith-Whitley, K. AU - Stuart, M. AU - Barakat, L. P. DA - Nov-Dec DO - 10.1093/jpepsy/jsv063 IS - 10 N1 - Daniel, Lauren C. Li, Yimei Smith, Kelsey Tarazi, Reem Robinson, M. Renee Patterson, Chavis A. Smith-Whitley, Kim Stuart, Marie Barakat, Lamia P. Daniel, Lauren/AAA-3700-2021 Daniel, Lauren/0000-0002-8637-2424 1465-735x PY - 2015 SN - 0146-8693 SP - 1085-1094 ST - Lessons Learned From a Randomized Controlled Trial of a Family-Based Intervention to Promote School Functioning for School-Age Children With Sickle Cell Disease T2 - Journal of Pediatric Psychology TI - Lessons Learned From a Randomized Controlled Trial of a Family-Based Intervention to Promote School Functioning for School-Age Children With Sickle Cell Disease UR - ://WOS:000364771600011 VL - 40 ID - 2214 ER - TY - JOUR AB - A 10-year-old male patient with homozygous sickle cell disease presents for a follow-up clinic visit after a recent hospitalization for a painful vasoocclusive event. His parents mention that in the past year he has had 4 hospitalizations for vasoocclusive events, 2 of which were complicated by the development of acute chest syndrome that resulted in transfer to the intensive care unit. He has missed many school days and may be retained a grade this year. He feels particularly sad about missing the school field trip that occurred during his last hospitalization. He also reports that he is not able to keep up with his friends when participating in physical activities at school. The child's parents are worried that he may be depressed. You as the provider discuss the option of hydroxyurea therapy. His parents ask if hydroxyurea would improve his overall well-being and functioning. AN - WOS:000323755900042 AU - Darbari, D. S. AU - Panepinto, J. A. DA - Dec DO - 10.1182/asheducation-2012.1.290 N1 - Darbari, Deepika S. Panepinto, Julie A. 1520-4383 PY - 2012 SN - 1520-4391 SP - 290-291 ST - What is the evidence that hydroxyurea improves health-related quality of life in patients with sickle cell disease? T2 - Hematology-American Society of Hematology Education Program TI - What is the evidence that hydroxyurea improves health-related quality of life in patients with sickle cell disease? UR - ://WOS:000323755900042 ID - 2404 ER - TY - JOUR AB - Purpose. Although more than 125 million North Americans have one or more chronic conditions, medical training may not adequately prepare physicians to care for them. The authors evaluated physicians' perceptions of the adequacy of their chronic illness care training to and the effects of training on their attitudes toward care of persons with chronic conditions. Method. In November 2000 through June 2001, the authors surveyed by telephone a random sample of U.S. physicians who had greater than or equal to20 hours of patient contact per week. The interview instrument examined demographics, career satisfaction, practice characteristics, perceived adequacy of chronic illness care training in ten competencies (geriatric syndromes, chronic pain, nutrition, developmental milestones, end-of-life care, psychosocial issues, patient education, assessment of caregiver needs, coordination of services, and interdisciplinary teamwork), and effect of training on attitudes toward chronic illness care. Results. Of 1,905 eligible physicians, 1,236 (65%) responded (270 family or general practitioners, 231 internists, 129 pediatricians, 335 nonsurgical specialists, and 271 surgeons). Most physicians reported their chronic disease training was less than adequate for all ten competencies. Family practitioners were more likely (p < .05) to report adequate training in seven competencies compared with internists, and in two to four competencies when compared with pediatricians, nonsurgical specialists, or surgeons. Most physicians reported that training had a positive effect on attitudes toward care of people with chronic conditions, including the ability to make a difference in their lives (74-84%). Conclusions. Physicians perceived their medical training for chronic illness care was inadequate. Medical schools and residencies may need to modify curricula to better prepare physicians to treat the growing number of people with chronic conditions. AN - WOS:000222831900007 AU - Darer, J. D. AU - Hwang, W. AU - Pham, H. H. AU - Bass, E. B. AU - Anderson, G. DA - Jun DO - 10.1097/00001888-200406000-00009 IS - 6 N1 - Darer, JD Hwang, W Pham, HH Bass, EB Anderson, G Bass, Eric/0000-0001-9106-527X 1938-808x PY - 2004 SN - 1040-2446 SP - 541-548 ST - More training needed in chronic care: A survey of US physicians T2 - Academic Medicine TI - More training needed in chronic care: A survey of US physicians UR - ://WOS:000222831900007 VL - 79 ID - 2791 ER - TY - JOUR AB - Background Functional Abdominal Pain Disorders (FAPDs) present a considerable burden to paediatric patients, impacting quality of life, school attendance and causing higher rates of anxiety and depression disorders. There are no international guidelines for the management of this condition. A previous Cochrane Review in 2011 found no evidence to support the use of antidepressants in this context. Objectives To evaluate the current evidence for the efficacy and safety of antidepressants for FAPDs in children and adolescents. Search methods In this updated review, we searched the Cochrane Library, PubMed, MEDLINE, Embase, PsycINFO and two clinical trial registers from inception until 03 February 2020. We also updated our search of databases of ongoing research, reference lists and 'grey literature' from inception to 03 February 2020. Selection criteria We included randomised controlled trials (RCTs) comparing antidepressants to placebo, to no treatment or to any other intervention, in children aged 4 to 18 years with a FAPD diagnosis as per the Rome or any other defined criteria (as defined by the authors). The primary outcomes of interest included treatment success (as defined by the authors), pain severity, pain frequency and withdrawal due to adverse events. Data collection and analysis Two review authors checked all citations independently, resolving disagreement with a third-party arbiter. We reviewed all potential studies in full text, and once again made independent decisions, with disagreements resolved by consensus. We conducted data extraction and 'Risk of bias' assessments independently, following Cochrane methods. Where homogeneous data were available, we performed metaanalysis using a random-effects model. We conducted GRADE analysis. Main results We found one new study in this updated search, making a total of three trials (223 participants) eligible for inclusion: two using amitriptyline (AMI) and one using citalopram.For the primary outcome of treatment success, two studies used reports of success on a symptom-based Likert scale, with either a twopoint reduction or the two lowest levels defined as success. The third study defined success as a 15% improvement in quality of life (QOL) ratings scales. Therefore, meta-analysis did not include this final study due to the heterogeneity of the outcome measure. There is lowcertainty evidence that there may be no difference when antidepressants are compared with placebo (risk ratio (RR) 1.17, 95% confidence interval (CI) 0.87 to 1.56; 2 studies, 205 participants; I-2 = 0%). We downgraded the evidence for significant imprecision due to extremely sparse data (see Summary of findings table 1). The third study reported that participants receiving antidepressants were significantly more likely than those receiving placebo to experience at least a 15% improvement in overall QOL score at 10 and 13 weeks (P = 0.007 and P = 0.002, respectively (absolute figures were not given)). The analysis found no difference in withdrawals due to adverse events between antidepressants and placebo: RR 3.17 (95% CI 0.65 to 15.33), with very low certainty due to high risk of bias in studies and imprecision due to low event and participant numbers. Sensitivity analysis using a fixed-eHect model and analysing just for AMI found no change in this result. Due to heterogeneous and limited reporting, no further meta-analysis was possible. Authors' conclusions There may be no difference between antidepressants and placebo for treatment success of FAPDs in childhood. There may be no difference in withdrawals due to adverse events, but this is also of low certainty. There is currently no evidence to support clinical decision making regarding the use of these medications. Further studies must consider sample size, homogenous and relevant outcome measures and longer follow up. AN - WOS:000624575100034 AU - de Bruijn, C. M. A. AU - Rexwinkel, R. AU - Gordon, M. AU - Benninga, M. AU - Tabbers, M. M. C7 - Cd008013 DO - 10.1002/14651858.CD008013.pub3 IS - 2 N1 - de Bruijn, Clara Marieke Andrea Rexwinkel, Robyn Gordon, Morris Benninga, Ma Tabbers, Merit M. Gordon, Morris/0000-0002-1216-5158 1361-6137 PY - 2021 SN - 1469-493X ST - Antidepressants for functional abdominal pain disorders in children and adolescents (Review) T2 - Cochrane Database of Systematic Reviews TI - Antidepressants for functional abdominal pain disorders in children and adolescents (Review) UR - ://WOS:000624575100034 ID - 1768 ER - TY - JOUR AB - Background and Objectives: Dysmenorrhea is commonly categorized into two types; primary and secondary. Primary dysmenorrhea (PD) is the focus of this review. PD is defined as painful menses with cramping sensation in the lower abdomen that is often accompanied by other symptoms, such as sweating, headache, nausea, vomiting, diarrhea, and tremulousness. All these symptoms occur just before or during the menses in women with normal pelvic anatomy. In adolescents the prevalence of PD varies between 16% and 93%, with severe pain perceived in 2% to 29% of the studied girls. Several studies suggest that severe menstrual pain is associated with absenteeism from school or work and limitation of other daily activities. One-third to one-half of females with PD are missing school or work at least once per cycle, and more frequently in 5% to 14% Of them. The wide variation in the prevalence rates may be attributed to the use of selected groups of subjects. Many risk factors are associated with increased severity of dysmenorrhea including earlier age at menarche, long menstrual periods, heavy menstrual flow, smoking and positive family history. Young women using oral contraceptive pills (OCP) report less severe dysmenorrhea. The considerably high prevalence of dysmenorrhea among adolescents verified that this condition is a significant public health problem that requires great attention. Summary of Main Results: Many methodological problems are encountered during quantifying and grading severity of pain related to dysmenorrhea. Quantifying and assessment tools depend on women's self-reporting with potential bias. There is a scarcity of longitudinal studies on the natural history of dysmenorrhea as well as the possible effects of many modifiable risk factors. In addition, the duration of follow-up in the available studies is relatively short. Therefore, several aspects are still open for research. Medical treatment for dysmenorrhea includes anti-inflammatory drugs (NSAIDs), OCP or surgical intervention. The efficacy of conventional treatments using NSAIDs and OCP is high. However, failure rate may reach up to 20% to 25%, besides the occurrence of drug-associated adverse effects. Only 6% of adolescents receive medical advice to treat dysmenorrhea while 70% practice self-management. Unfortunately, some girls even abuse these medications (non-therapeutic high doses) for quick pain relief. The persistence of dysmenorrhea despite the use of OCP and/or NSAIDs drugs is a strong indicator of an organic pelvic disease. This condition mandates an appropriate referral to a gynecologist with proper laparoscopic diagnosis of endometriosis and/or other pelvic diseases. Conclusions: Dysmenorrhea is an important health problem for adolescent., school and occupational as well as practitioners that adversely affects the daily activities and quality of life for adolescent women. The accurate prevalence of dysmenorrhea is difficult to establish due to the variety of diagnostic criteria and the subjective nature of the symptoms. In adolescents, moderate to severe dysmenorrhea that affects lifestyle and does not respond to medical treatment requires professional attention and proper diagnosis of possible underlying pelvic disease. Therefore, adolescent care providers should be more knowledgeable and actively involved in the care of dysmenorrhea. AN - WOS:000368465300004 AU - De Sanctis, V. AU - Soliman, A. AU - Bernasconi, S. AU - Bianchin, L. AU - Bona, G. AU - Bozzola, M. AU - Buzi, F. AU - De Sanctis, C. AU - Tonini, G. AU - Rigon, F. AU - Perissinotto, E. DA - Dec IS - 2 N1 - De Sanctis, Vincenzo Soliman, Ashraf Bernasconi, Sergio Bianchin, Luigi Bona, Gianni Bozzola, Mauro Buzi, Fabio De Sanctis, Carlo Tonini, Giorgio Rigon, Franco Perissinotto, Egle Bernasconi, Sergio/AAA-9419-2021 Soliman, ashraf/0000-0002-7145-6561 PY - 2015 SN - 1565-4753 SP - 512-520 ST - Primary Dysmenorrhea in Adolescents: Prevalence, Impact and Recent Knowledge T2 - Pediatric Endocrinology Reviews Per TI - Primary Dysmenorrhea in Adolescents: Prevalence, Impact and Recent Knowledge UR - ://WOS:000368465300004 VL - 13 ID - 2202 ER - TY - JOUR AB - The objective was to determine the prevalence of lower back pain in adolescents and its relationship to sports and sedentary activities. We conducted a cross-sectional study of 5th to 8th-grade students (n = 1,236) in Bauru, Sao Paulo State, Brazil. We used a structured protocol and the Nordic questionnaire for musculoskeletal symptoms. The analysis was performed using a descriptive approach and bivariate and multivariate binary logistic regression. Prevalence of lower back pain was 19.5% (7% in boys and 12.5% in girls), with statistically significant differences according to gender (p < 0.00001), age (p = 0.0057), and sports (p = 0.0001). Bivariate and multivariate analyses showed independent associations between lower back pain and female gender, time watching TV, and sports. Lower back pain in schoolchildren can persist as chronic pain in adults. Understanding the relationships between variables should provide useful measures for maintaining, improving, and promoting students' wellbeing. AN - WOS:000294439000007 AU - De Vitta, A. AU - Martinez, M. G. AU - Piza, N. T. AU - Simeao, Sfdp AU - Ferreira, N. P. DA - Aug DO - 10.1590/s0102-311x2011000800007 IS - 8 N1 - De Vitta, Alberto Martinez, Mariana Goncalez Piza, Nathalia Toledo de Almeida Penteado Simeao, Sandra Fiorelli Ferreira, Nathalia Pascucci De Vitta, Alberto/AAV-2210-2020 1678-4464 PY - 2011 SN - 0102-311X SP - 1520-1528 ST - Prevalence of lower back pain and associated factors in students T2 - Cadernos De Saude Publica TI - Prevalence of lower back pain and associated factors in students UR - ://WOS:000294439000007 VL - 27 ID - 2482 ER - TY - JOUR AB - OBJECTIVE: To evaluate the currently published data pertaining to the efficacy and safety of topiramate for prophylaxis of classic and common migraine in pediatric patients. DATA SOURCES: The literature was identified via PubMed (through April 2013) and Iowa Drug Information System (through April 2013). References from identified articles were also reviewed. STUDY SELECTION AND DATA EXTRACTION: Data were included from studies of efficacy and safety in pediatric patients experiencing migraine (with or without aura), as defined by the International Headache Society. Studies including patients with more specific types of migraine, such as basilar migraine, were excluded. DATA SYNTHESIS: Eight publicatons were identified, including 3 randomized controlled trials (RCTs), a subgroup analysis, and 4 observational studies. These studies reported a decrease in headache frequency ranging from 63% to 100% for doses of 100 mg/d and 65% for 200 mg/d. Response to therapy, defined as ≥50% reduction in migraine rate, was also reported in 83% to 95% of patients receiving topiramate. Topiramate is generally well tolerated. Adverse effects were dose related and included paresthesias, weight loss, and cognitive adverse effects. CONCLUSION: Topiramate is an effective and well-tolerated prophylactic therapy for use in pediatric migraine patients. Doses of 100 and 200 mg/d (1.47-2.0 mg/kg/d) effectively decrease the frequency of migraine headaches, with 100 mg/d providing optimal benefit-to-risk ratio. Additional randomized, double-blind, placebo-controlled studies are needed to determine the impact of the drug on quality-of-life outcomes, such as school function, and migraine severity and duration. AD - University of Toledo, Toledo, OH, USA. AN - 24566461 AU - Deaton, T. L. AU - Mauro, L. S. DA - May DO - 10.1177/1060028014521128 DP - NLM ET - 2014/02/26 IS - 5 KW - Child Fructose/adverse effects/*analogs & derivatives/therapeutic use Humans Migraine Disorders/*prevention & control Neuroprotective Agents/adverse effects/*therapeutic use Topiramate Treatment Outcome adolescent migraine pediatric prophylaxis LA - eng N1 - 1542-6270 Deaton, Tamara L Mauro, Laurie S Journal Article Review United States Ann Pharmacother. 2014 May;48(5):638-43. doi: 10.1177/1060028014521128. Epub 2014 Feb 24. PY - 2014 SN - 1060-0280 SP - 638-43 ST - Topiramate for migraine prophylaxis in pediatric patients T2 - Ann Pharmacother TI - Topiramate for migraine prophylaxis in pediatric patients VL - 48 ID - 3754 ER - TY - JOUR AB - The first attack of hemiplegic migraine occurred in most cases between the 10th and 15th year of life in 14 children (8 boys and 6 girls). Most attacks took place with intervals of 3-6 and 6-12 months. Only rarely did they last longer than 24 hours. Precipitating factors (emotional and physical stress, change of weather, influence of light or heat) were given in 6 cases. As many as 7 children attended higher schools with good or average success. A family history, mainly from the maternal side, existed in 11 cases. Sensory symptoms were demonstrable in all children, motor symptoms in 9 and visual symptoms in 13. Ten children had speech disturbances. Hand, lower arm, cheek and tongue were most frequently involved in sensory and motor symptoms. Out of 9 attacks registered with an EEG severe focal signs (delta or theta-delta foci) were demonstrable contralaterally in all children, in 8 children there were also signs of generalized disturbances. AN - 7371528 AU - Degen, R. AU - Degen, H. E. AU - Palm, D. AU - Meiser, W. DA - May 2 DO - 10.1055/s-2008-1070721 DP - NLM ET - 1980/05/02 IS - 18 KW - Adolescent Adult Age Factors Child Electroencephalography Female Hemiplegia/*complications Humans Male Migraine Disorders/complications/*diagnosis/genetics Nervous System Diseases/complications Sensation Speech Disorders/complications Vision Disorders/complications LA - ger N1 - Degen, R Degen, H E Palm, D Meiser, W English Abstract Journal Article Germany Dtsch Med Wochenschr. 1980 May 2;105(18):640-5. doi: 10.1055/s-2008-1070721. OP - Die Migraine hémiphlégique im Kindesalter. PY - 1980 SN - 0012-0472 (Print) 0012-0472 SP - 640-5 ST - [Hemiplegic migraine in childhood (author's transl)] T2 - Dtsch Med Wochenschr TI - [Hemiplegic migraine in childhood (author's transl)] VL - 105 ID - 3462 ER - TY - JOUR AB - BACKGROUND: Ethiopian school children often carry school supplies in heavy school bags and encounter limited school facilities. This stresses their vulnerable musculoskeletal system and may result in experiencing musculoskeletal pain. High prevalence of musculoskeletal pain has been documented, but data on musculoskeletal pain among elementary school children in Ethiopia is lacking. To determine the prevalence of musculoskeletal pain and associated factors among elementary school children in Gondar, Ethiopia. METHODS: Cross-sectional study was conducted among children from six randomly selected elementary schools. Sample size was determined proportionally across school grades and governmental and private schools to ensure variety within the sample. Data collection consisted of physical measurements including height, weight and schoolbag weight, and a structured questionnaire on musculoskeletal pain, mode of transport, walking time and school facilities. Data were analysed descriptively and through uni- and multivariate logistic regression model. RESULTS: In total 723 children participated. The overall prevalence of self-reported musculoskeletal pain was 62%, with a significant difference between school types (governmental 68% versus private 51%). Shoulder, neck and lower leg/knee were most commonly reported. Walking to and from school for ≥20 min (OR = 2.94, 95% CI 2.05 to 4.21) and relative school bag weight (OR = 2.57, 95% CI 1.48 to 4.47) were found significantly associated with self-report musculoskeletal pain. Children with carrying heavy school supplies and also walking long duration have a 3.5 (95% CI = 1.80-6.95) times greater chance of reporting pain as compared to those who carry lesser weighed bags and reported shorter walking duration at the same time. CONCLUSIONS: Prevalence of self-reported musculoskeletal pain was high among children attending public schools and also those who walked a long way to and from school. Long walking duration and relative school bag weight were significantly associated with musculoskeletal pain. These findings can inform policymakers to provide transportation services and other facilities at elementary schools. The findings of this study should be interpreted with caution due to possible social desirability bias with higher prevalence of self-reported pain and more so in children population. AU - Delele, Manayesh AU - Janakiraman, Balamurugan AU - Bekele Abebe, Abey AU - Tafese, Ararso AU - van de Water, Alexander T. M. DA - 2018/07/31/ DO - 10.1186/s12891-018-2192-6 DP - PubMed IS - 1 J2 - BMC Musculoskelet Disord KW - Adolescent Adolescent Development Age Distribution Child Child Development Child, Preschool Cross-Sectional Studies Ethiopia Female Humans Lifting Male Musculoskeletal pain Musculoskeletal System Prevalence Private Sector Public Sector Risk Factors School bag School children Schools Students Time Factors Walking Walking distance Weight-Bearing LA - eng PY - 2018 SN - 1471-2474 SP - 276 ST - Musculoskeletal pain and associated factors among Ethiopian elementary school children T2 - BMC musculoskeletal disorders TI - Musculoskeletal pain and associated factors among Ethiopian elementary school children UR - http://www.ncbi.nlm.nih.gov/pubmed/30064400 VL - 19 ID - 65 ER - TY - JOUR AB - Little is known about adherence to antiretroviral therapy (ART) among adolescents in sub-Saharan Africa, where the majority of the world's HIV-positive adolescents reside. We assessed individual, household, and HIV self-management characteristics associated with a 48-hour treatment gap in the preceding 3 months, and a pharmacy medication possession ratio (MPR) that assessed the number of ART pills dispensed divided by the number of ART pills required in the past 6 months, among 285 Zambians, ages 15-19 years. Factors significantly associated with a 48-hour treatment gap were being male, not everyone at home being aware of the adolescent's HIV status, and alcohol use in the past month. Factors associated with an MPR < 90% included attending the clinic alone, alcohol use in the past month, and currently not being in school. Findings support programs to strengthen adolescents' HIV management skills with attention to alcohol use, family engagement, and the challenges adolescents face transitioning into adulthood, especially when they are no longer in school. AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street E5032, Baltimore, MD, 21205, USA. jdenison@jhu.edu. Reproductive, Maternal, Newborn, Child Health Division, FHI 360, Durham, NC, USA. Contraceptive Technology Innovation Department, FHI 360, Durham, NC, USA. FHI 360, Ndola, Zambia. Health Services Research, FHI 360, Durham, NC, USA. FHI 360, Lusaka, Zambia. Arthur Davison Children's Hospital, Ndola, Zambia. AN - 29103190 AU - Denison, J. A. AU - Packer, C. AU - Stalter, R. M. AU - Banda, H. AU - Mercer, S. AU - Nyambe, N. AU - Katayamoyo, P. AU - Mwansa, J. K. AU - McCarraher, D. R. DA - Mar DO - 10.1007/s10461-017-1944-x DP - NLM ET - 2017/11/06 IS - 3 KW - Adolescent Alcohol Drinking/*adverse effects/epidemiology Ambulatory Care Facilities Antiretroviral Therapy, Highly Active/*methods Cross-Sectional Studies Family Characteristics Female HIV Infections/*drug therapy/epidemiology/*psychology Humans Male Medication Adherence/psychology/*statistics & numerical data Pain Management Schools Young Adult Zambia/epidemiology *Adherence *Adolescents *Antiretroviral therapy (ART) *Caregivers *hiv *Sub-Saharan Africa *Youth *Zambia LA - eng N1 - 1573-3254 Denison, Julie A Packer, Catherine Stalter, Randy M Banda, Harry Mercer, Sarah Nyambe, Namakau Katayamoyo, Patrick Mwansa, Jonathan K McCarraher, Donna R P30 AI094189/AI/NIAID NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States AIDS Behav. 2018 Mar;22(3):996-1005. doi: 10.1007/s10461-017-1944-x. PY - 2018 SN - 1090-7165 SP - 996-1005 ST - Factors Related to Incomplete Adherence to Antiretroviral Therapy among Adolescents Attending Three HIV Clinics in the Copperbelt, Zambia T2 - AIDS Behav TI - Factors Related to Incomplete Adherence to Antiretroviral Therapy among Adolescents Attending Three HIV Clinics in the Copperbelt, Zambia VL - 22 ID - 3889 ER - TY - JOUR AB - Background: Foreign body (FB) ingestions are common in children presenting to the emergency department. Health care providers are quickly challenged to determine which children need urgent endoscopy for diagnostic or therapeutic reasons. We performed a retrospective study to determine if esophageal injury caused by FB ingestion correlated to presenting signs or symptoms, location of impaction, duration of impaction, or denomination of coin (as this was the most commonly ingested FB). Methods: A retrospective chart review of children between birth and 17 years of age who presented for esophagogastroduodenoscopy for removal of upper gastrointestinal FB was performed. Demographic data collected from all children included age, sex, and race. For children with FB ingestion, the type of FB, location of the FB, underlying gastrointestinal pathology, duration of impaction, and endoscopic findings were recorded. Descriptive analysis of the data was performed using means, medians, SD, and percentages; chi(2) test was used to test the association between categorical variables. Results: Over a 10-year period of review, a total of 3279 esophago-gastroduodenoscopies were performed; 248 (7.8%) were done for FB removal. The mean age for children having endoscopy for FB removal was 3.9 (SD, 3.2) years (median, 3.1 years); there was a slight male predominance (male/female ratio = 1.6:1). The vast majority (81%) of retained FBs was coins. Most of the FBs were located in the upper esophagus (68%). Success rate for retrieval was greater for esophageal FBs (99%) than for more distally located FBs (70%; P < 0.001). Mucosal ulceration, seen in 59 children (30%), was related to a complaint of substernal pain but not vomiting, respiratory distress, or drooling. The finding of esophageal ulceration was not related to location of coin impaction or denomination of ingested coin but was related to duration of impaction and the unexpected finding of FB during chest radiograph. Underlying pathology was found more commonly in children with meat bolus impaction (100%) than in children with other FB ingestions (3.6%; P < 0.001). Conclusions: Ingestion of FBs by children remains a significant problem faced by emergency department personnel. In our study, a complaint of substernal chest pain in children with an esophageal FB predicted esophageal ulceration. Also, esophageal FBs unexpectedly found on chest radiograph or known to be present greater than 72 hours were more likely to have esophageal ulceration. These clinical and historic clues can help direct appropriate prompt referral for endoscopic removal. AN - WOS:000307803500001 AU - Denney, W. AU - Ahmad, N. AU - Dillard, B. AU - Nowicki, M. J. DA - Aug DO - 10.1097/PEC.0b013e31826248eb IS - 8 N1 - Denney, William Ahmad, Naveed Dillard, Benjamin Nowicki, Michael J. 1535-1815 PY - 2012 SN - 0749-5161 SP - 731-734 ST - Children Will Eat the Strangest Things A 10-Year Retrospective Analysis of Foreign Body and Caustic Ingestions From a Single Academic Center T2 - Pediatric Emergency Care TI - Children Will Eat the Strangest Things A 10-Year Retrospective Analysis of Foreign Body and Caustic Ingestions From a Single Academic Center UR - ://WOS:000307803500001 VL - 28 ID - 2420 ER - TY - JOUR AB - CONTEXT AND OBJECTIVE: Chronic spinal pain, especially low-back pain and neck pain, is a leading cause of years of life with disability. The aim of the present study was to estimate the prevalence of chronic spinal pain among individuals aged 15 years or older and to identify the factors associated with it. DESIGN AND SETTING: Cross-sectional epidemiological study on a sample of the population of the city of São Paulo. METHOD: Participants were selected using random probabilistic sampling and data were collected via face-to-face interviews. The Hospital Anxiety and Depression Scale (HADS), EuroQol-5D, Alcohol Use Disorders Identification Test (AUDIT), Fagerström test for nicotine dependence and Brazilian economic classification criteria were used. RESULTS: A total of 826 participants were interviewed. The estimated prevalence of chronic spinal pain was 22% (95% confidence interval, CI: 19.3-25.0%). The factors independently associated with chronic spinal pain were: female sex, age 30 years or older, schooling level of four years or less, symptoms compatible with anxiety and high physical exertion during the main occupation. Quality of life and self-rated health scores were significantly worse among individuals with chronic spinal pain. CONCLUSION: The prevalence of chronic spinal pain in this segment of the population of São Paulo was 22.0%. The factors independently associated with chronic pain were: female sex, age 30 years or older, low education, symptoms compatible with anxiety and physical exertion during the main occupation. AD - DC, MSc. Associate Professor, Instituto Paulista de Pós-Graduação (IPPG), São Paulo, SP, Brazil. MD, DC, PhD. Private Practice, Axis Clinica de Coluna, São Paulo, SP, Brazil. DC, MSc. Associate Professor, Universidade Anhembi Morumbi, São Paulo, SP, Brazil. MD, PhD. Professor, Department of Preventive Medicine, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil. AN - 27901240 AU - Depintor, J. D. AU - Bracher, E. S. AU - Cabral, D. M. AU - Eluf-Neto, J. DA - Sep-Oct DO - 10.1590/1516-3180.2016.0091310516 DP - NLM ET - 2016/12/03 IS - 5 KW - Adolescent Adult Age Distribution Age Factors Aged Back Pain/*epidemiology/*etiology Brazil/epidemiology Chronic Pain/*epidemiology/*etiology Cross-Sectional Studies Female Humans Male Middle Aged Multivariate Analysis Neck Pain/*epidemiology/*etiology Prevalence Quality of Life Risk Factors Sex Distribution Sex Factors Socioeconomic Factors Surveys and Questionnaires Young Adult LA - eng N1 - 1806-9460 Depintor, Jidiene Dylese Presecatan Bracher, Eduardo Sawaya Botelho Cabral, Dayane Maia Costa Eluf-Neto, José Journal Article Brazil Sao Paulo Med J. 2016 Sep-Oct;134(5):375-384. doi: 10.1590/1516-3180.2016.0091310516. PY - 2016 SN - 1516-3180 SP - 375-384 ST - Prevalence of chronic spinal pain and identification of associated factors in a sample of the population of São Paulo, Brazil: cross-sectional study T2 - Sao Paulo Med J TI - Prevalence of chronic spinal pain and identification of associated factors in a sample of the population of São Paulo, Brazil: cross-sectional study VL - 134 ID - 3539 ER - TY - JOUR AB - BACKGROUND: Studies done in Saudi Arabia showed a high prevalence of headache among university students. Limited research was done to assess the relationship between headache and psychiatric disorders. The aim of this study was to assess the prevalence and association between migraine, tension-type headache, and depression among Saudi female students in Taif University. PARTICIPANTS AND METHODS: A cross-sectional study using self-administered questionnaires about headache and depression was conducted at the Taif University on 1340 female students in the academic year 2016-2017. The Beck Depression Inventory, the ID Migraine™ screening tool, and the criteria of the International Headache Society were used to investigate the depressive symptoms and headache types. RESULTS: The self-reported headache prevalence was 68.4%, and the prevalence of migraine, tension-type headache (TTH), and depression was 32.5%, 29.5%, and 6.2%, respectively. The main migraine trigger was stress or anxiety; 86.6% of migraineurs had a positive family history, and only 11.9% sought medical care for headache. Of students with TTH, 61.1% reported family history and only 12.4% sought medical care. Paracetamol was the commonly used analgesic for all headache types. Medical students and students in older grades showed significantly higher levels of all headache types. Depression prevalence was significantly higher among migraineurs and students who suffered higher headache frequencies. CONCLUSION: The study demonstrated a high prevalence of headache among the studied students and an association between headache and depression. The study calls for increasing awareness towards headache and the importance of seeking medical consultation. Management strategies should be planned for the observed headache and depression comorbidity. AD - 1Department of Family and Community Medicine, College of Medicine, Taif University, Alsalama street, Taif city, Saudi Arabia. ISNI: 0000 0004 0419 5255. GRID: grid.412895.3 2Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt. ISNI: 0000 0004 0621 4712. GRID: grid.411775.1 AN - 30774147 AU - Desouky, D. E. AU - Zaid, H. A. AU - Taha, A. A. C2 - PMC6351506 DO - 10.1186/s42506-019-0008-7 DP - NLM ET - 2019/02/19 IS - 1 KW - Acetaminophen/therapeutic use Adult Analgesics, Non-Narcotic/therapeutic use Anxiety/epidemiology Comorbidity Cross-Sectional Studies Depression/*epidemiology Female Humans Migraine Disorders/drug therapy/*epidemiology Prevalence Psychiatric Status Rating Scales Saudi Arabia/epidemiology Stress, Psychological/epidemiology Students/*statistics & numerical data Tension-Type Headache/drug therapy/*epidemiology Universities Young Adult Depression Headache Migraine Saudi University University and from the deanships of the colleges included in the study. As long as the study does not take samples from humans, there is no probability of a potential harm and all students were more than 18 years, the ethics committee approved obtaining verbal consents from the respondent students before sharing in the studyThe manuscript does not contain any individual person’s data in any form (individual details, images or videos).The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. LA - eng N1 - 2090-262x Desouky, Dalia E Zaid, Hany A Taha, Azza A Journal Article J Egypt Public Health Assoc. 2019;94(1):7. doi: 10.1186/s42506-019-0008-7. Epub 2019 Jan 29. PY - 2019 SN - 0013-2446 (Print) 0013-2446 SP - 7 ST - Migraine, tension-type headache, and depression among Saudi female students in Taif University T2 - J Egypt Public Health Assoc TI - Migraine, tension-type headache, and depression among Saudi female students in Taif University VL - 94 ID - 3534 ER - TY - JOUR AB - Little is known about the prevalence of functional gastrointestinal diseases (FGDs) in adolescents, especially in developing countries. This cross-sectional survey conducted in a semi-urban school in Sri Lanka, assessed the prevalence of whole spectrum of FGDs in 427 adolescents (age 12-16 years) using a validated self-administered questionnaire. According to Rome III criteria, 123 (28.8%) adolescents had FGDs. Of them, 59 (13.8%) had abdominal-pain-related FGDs [irritable bowel syndrome (IBS) 30, functional dyspepsia 15, functional abdominal pain 13 and abdominal migraine 1]. Prevalence of functional constipation, aerophagia, adolescent rumination syndrome, cyclical vomiting syndrome and non-retentive faecal incontinence were 4.2, 6.3, 4, 0.5 and 0.2%, respectively. Only 58 (13.6%) adolescents were found to have FGDs when Rome II criteria were used. In conclusion, FGDs were present in more than one-fourth of adolescents in the study group, of which IBS was the most common. Rome III criteria were able to diagnose FGDs more comprehensively than Rome II. AD - Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. niranga1230@lycos.com AN - 20525779 AU - Devanarayana, N. M. AU - Adhikari, C. AU - Pannala, W. AU - Rajindrajith, S. DA - Feb DO - 10.1093/tropej/fmq039 DP - NLM ET - 2010/06/08 IS - 1 KW - Abdominal Pain/diagnosis/epidemiology/etiology Adolescent Aerophagy/diagnosis/*epidemiology Child Constipation/diagnosis/*epidemiology Cross-Sectional Studies Dyspepsia/diagnosis/*epidemiology Fecal Incontinence/epidemiology Female Gastrointestinal Diseases/*classification/diagnosis/*epidemiology Humans Male Migraine Disorders/classification/diagnosis Prevalence Severity of Illness Index Sri Lanka/epidemiology Surveys and Questionnaires Vomiting LA - eng N1 - 1465-3664 Devanarayana, Niranga Manjuri Adhikari, Chandralatha Pannala, Waruni Rajindrajith, Shaman Comparative Study Journal Article England J Trop Pediatr. 2011 Feb;57(1):34-9. doi: 10.1093/tropej/fmq039. Epub 2010 Jun 4. PY - 2011 SN - 0142-6338 SP - 34-9 ST - Prevalence of functional gastrointestinal diseases in a cohort of Sri Lankan adolescents: comparison between Rome II and Rome III criteria T2 - J Trop Pediatr TI - Prevalence of functional gastrointestinal diseases in a cohort of Sri Lankan adolescents: comparison between Rome II and Rome III criteria VL - 57 ID - 3615 ER - TY - JOUR AB - Background and Objective: Functional gastrointestinal disorders (FGD) are common among children, but little is known regarding their prevalence in developing countries. We assessed the prevalence of abdominal pain-predominant FGD, in addition to the predisposing factors and symptomatology, in Sri Lankan children. Patients and Methods: A cross-sectional survey was conducted among a randomly selected group of 10-to 16-year-olds in 8 randomly selected schools in 4 provinces in Sri Lanka. A validated, self-administered questionnaire was completed by children independently in an examination setting. FGD were diagnosed using Rome III criteria. Results: A total of 2180 questionnaires were distributed and 2163 (99.2%) were included in the analysis (1189 [55%] boys, mean age 13.4 years, standard deviation 1.8 years). Of them, 270 (12.5%) had at least 1 abdominal pain-predominant FGD. Irritable bowel syndrome (IBS) was seen in 107 (4.9%), functional dyspepsia in 54 (2.5%), functional abdominal pain in 96 (4.4%), and abdominal migraine (AM) in 21 (1.0%) (2 had AM and functional dyspepsia, 6 had AM and IBS). Extraintestinal symptoms were more common among affected children (P < 0.05). Abdominal pain-predominant FGD were higher in girls and those exposed to stressful events (P < 0.05). Prevalence negatively correlated with age (r = -0.05, P = 0.02). Conclusions: Abdominal pain-predominant FGD affects 12.5% of children ages 10 to 16 years and constitutes a significant health problem in Sri Lanka. IBS is the most common FGD subtype present. Abdominal pain-predominant FGD are higher in girls and those exposed to emotional stress. Prevalence of FGD decreased with age. Extraintestinal symptoms are more frequent in affected children. AN - WOS:000297542700016 AU - Devanarayana, N. M. AU - Mettananda, S. AU - Liyanarachchi, C. AU - Nanayakkara, N. AU - Mendis, N. AU - Perera, N. AU - Rajindrajith, S. DA - Dec DO - 10.1097/MPG.0b013e3182296033 IS - 6 N1 - Devanarayana, Niranga Manjuri Mettananda, Sachith Liyanarachchi, Chathurangi Nanayakkara, Navoda Mendis, Niranjala Perera, Nimnadi Rajindrajith, Shaman Mettananda, Sachith/H-4640-2019 Mettananda, Sachith/0000-0002-0760-0418; Devanarayana, Niranga Manjuri/0000-0002-2988-110X 1536-4801 PY - 2011 SN - 0277-2116 SP - 659-665 ST - Abdominal Pain-Predominant Functional Gastrointestinal Diseases in Children and Adolescents: Prevalence, Symptomatology, and Association With Emotional Stress T2 - Journal of Pediatric Gastroenterology and Nutrition TI - Abdominal Pain-Predominant Functional Gastrointestinal Diseases in Children and Adolescents: Prevalence, Symptomatology, and Association With Emotional Stress UR - ://WOS:000297542700016 VL - 53 ID - 2466 ER - TY - JOUR AB - Background: Abdominal pain predominant functional gastrointestinal diseases (AP-FGD) are commonly seen in the paediatric age group. It has significant impact on daily activities of affected children. Main objective of this study was to assess the health related quality of life (HRQoL) in children with AP-FGD. Method: This was a cross sectional survey conducted in children aged 13-18 years, in four randomly selected schools in Western province of Sri Lanka. Data was collected using a previously validated, self-administered questionnaire. It had questions on symptoms, HRQoL and health care consultation. AP-FGD were diagnosed using Rome III criteria. Results: A total of 1850 questionnaires were included in the analysis [males 1000 (54.1%), mean age 14.4 years and SD 1.3 years]. Of them, 305 (16.5%) had AP-FGD [irritable bowel syndrome = 91(4.9%), functional dyspepsia = 11 (0.6%), abdominal migraine = 37 (1.9%) and functional abdominal pain = 180 (9.7%)]. Lower HRQoL scores for physical (83.6 vs. 91.4 in controls), social (85.0 vs. 92.7), emotional (73.6 vs. 82.7) and school (75.0 vs. 82.5) functioning domains, and lower overall scores (79.6 vs. 88.0) were seen in children with AP-FGD (p < 0.001). A weak but significant negative correlation was observed between HRQoL score and severity of abdominal pain (r = -0.24, p < 0.0001). Eighty five children (27.9%) had sought healthcare for AP-FGD. Factors determining healthcare seeking were presence of abdominal bloating and vomiting (p < 0.05). Conclusions: Children with AP-FGD have lower quality of life in all 4 domains. Those with severe symptoms have lower HRQoL. Approximately 28% of children with AP-FGD seek healthcare for their symptoms. AN - WOS:000340921600001 AU - Devanarayana, N. M. AU - Rajindrajith, S. AU - Benninga, M. A. C7 - 150 DA - Aug DO - 10.1186/1471-230x-14-150 N1 - Devanarayana, Niranga Manjuri Rajindrajith, Shaman Benninga, Marc A. Devanarayana, Niranga Manjuri/0000-0002-2988-110X 1471-230x PY - 2014 ST - Quality of life and health care consultation in 13 to 18 year olds with abdominal pain predominant functional gastrointestinal diseases T2 - Bmc Gastroenterology TI - Quality of life and health care consultation in 13 to 18 year olds with abdominal pain predominant functional gastrointestinal diseases UR - ://WOS:000340921600001 VL - 14 ID - 2293 ER - TY - JOUR AB - Context: Recurrent abdominal pain is one of the commonest gastrointestinal complaints in children, affecting approximately 10% of school aged children and adolescents. There is no consensus with regards to etiology, investigation and management of this common problem. This review addresses some of the issues related to epidemiology, etiology, management and prognosis of recurrent abdominal pain. Evidence acquisition: We reviewed current literature on this broad subject, specially concentrating on epidemiology, etiology and, basic and advanced management strategies, from 1958 to date, using PubMed, Embase, Cochrane database and cross references. Results: The majority of the affected children have functional gastrointestinal diseases. The exact cause of pain remains obscure. New evidence suggests that emotional stress, visceral hypersensitivity and gastrointestinal motility disorders may play a vital part in its origin. Pharmacological treatments are commonly used in an effort to manage symptoms, despite the lack of data supporting their efficacy. Conclusions: Most children with recurrent abdominal pain have functional gastrointestinal diseases and a detailed history, examination and basic stool, urine and hematological investigations are sufficient to exclude organic pathology in them. Despite the magnitude of the problem, knowledge on the effective management options is poor. AN - WOS:000266355900004 AU - Devanarayana, N. M. AU - Rajindrajith, S. AU - de Silva, H. J. DA - May IS - 5 N1 - Devanarayana, Niranga Manjuri Rajindrajith, Shaman de Silva, H. Janaka Devanarayana, Niranga Manjuri/0000-0002-2988-110X 0974-7559 PY - 2009 SN - 0019-6061 SP - 389-399 ST - Recurrent Abdominal Pain in Children T2 - Indian Pediatrics TI - Recurrent Abdominal Pain in Children UR - ://WOS:000266355900004 VL - 46 ID - 2604 ER - TY - JOUR AB - Abdominal pain-predominant functional gastrointestinal diseases (AP-FGD) are common in children and commonly attributed to exposure to child abuse. However, this relationship has not been studied in teenagers, and the main objective of the current study was to assess it. Teenagers were recruited from four randomly selected schools in Western province of Sri Lanka. Data were collected using a validated self-administered questionnaire. AP-FGD were diagnosed using Rome III criteria. A total of 1850 teenagers aged 13-18 years were included. Three hundred and five (16.5%) had AP-FGD. AP-FGD were significantly higher in those exposed to sexual (34.0%), emotional (25.0%) and physical (20.2%) abuse, than in those not abused (13.0%, p < 0.001). Those with AP-FGD exposed to abuse had a higher severity score for bowel symptoms (30.8% vs. 24.7% in not abused, p < 0.05). This study highlights the importance of identifying exposure to abuse in management of teenagers with AP-FGD. AN - WOS:000343058700010 AU - Devanarayana, N. M. AU - Rajindrajith, S. AU - Perera, M. S. AU - Nishanthanie, S. W. AU - Karunanayake, A. AU - Benninga, M. A. DA - Oct DO - 10.1093/tropej/fmu035 IS - 5 N1 - Devanarayana, Niranga Manjuri Rajindrajith, Shaman Perera, Madushanka S. Nishanthanie, Samudu W. Karunanayake, Amaranath Benninga, Marc A. Karunanayake, Amaranath/AAG-3419-2020 KARUNANAYAKE, AMARANATH/0000-0001-5836-6329; Devanarayana, Niranga Manjuri/0000-0002-2988-110X 1465-3664 PY - 2014 SN - 0142-6338 SP - 386-392 ST - Association Between Functional Gastrointestinal Diseases and Exposure to Abuse in Teenagers T2 - Journal of Tropical Pediatrics TI - Association Between Functional Gastrointestinal Diseases and Exposure to Abuse in Teenagers UR - ://WOS:000343058700010 VL - 60 ID - 2282 ER - TY - JOUR AB - Examined the role of socioecological factors (family functioning and socioeconomic variables) in predicting behavioral and cognitive adaptation in children with sickle cell syndromes (SCD). Participants included 74 African American children and adolescents with SCD and their primary caretakers. Outcomes included internalizing and externalizing behavior symptoms, as rated by caretakers, as well as intellectual abilities and academic achievement, as assessed by individually administered standardized instruments. Family functioning consisted of both caretaker adjustment and family environment (i.e., family adaptability and cohesion). Hierarchical multiple regression analyses revealed that caretaker psychological adjustment predicted externalizing behaviors, while family environment (i.e., adaptability and cohesion) predicted neither behavioral nor cognitive functioning. Socioeconomic variables alone predicted intellectual abilities and academic achievement and also contributed to the prediction of child behavioral adaptation. Results are discussed in terms of relevant sociocultural issues and implications for family-level prevention and intervention. AN - WOS:000076301400006 AU - Devine, D. AU - Brown, R. T. AU - Lambert, R. AU - Donegan, J. E. AU - Eckman, J. DA - Sep DO - 10.1023/a:1026254119939 IS - 3 N1 - Devine, D Brown, RT Lambert, R Donegan, JE Eckman, J Brown, Ronald/0000-0002-9656-4614 PY - 1998 SN - 1068-9583 SP - 295-313 ST - Predictors of psychosocial and cognitive adaptation in children with sickle cell syndromes T2 - Journal of Clinical Psychology in Medical Settings TI - Predictors of psychosocial and cognitive adaptation in children with sickle cell syndromes UR - ://WOS:000076301400006 VL - 5 ID - 2890 ER - TY - JOUR AB - Introduction and aims: Functional gastrointestinal disorders are among the most common chronic disorders in children worldwide. Studies in schoolchildren from various Latin American countries have shown a high prevalence of functional gastrointestinal disorders, but their prevalence in Mexican schoolchildren is unknown. Our aim was to assess the prevalence of functional gastrointestinal disorders in Mexican schoolchildren in accordance with the Rome III criteria. Material and methods: Children and adolescents from public and private schools in Monterrey and Cuernavaca privately completed the Spanish version of the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-III) in class, using the same methods and questionnaires of previous studies conducted by our group in other Latin American countries. Results: A total of 362 schoolchildren (public school 82, private school 280), with a mean age of 11.6 +/- 2.1 years completed the QPGS-III. Ninety-nine schoolchildren (27.3%) met the criteria for a FGID, according to the Rome III criteria. Functional constipation was the most common FGID (12.6%). Irritable bowel syndrome (6.4%) was the most common FGID associated with abdominal pain. There was no significant difference in the prevalence of FGIDs between sexes (P=.8). Conclusions: We found a high prevalence of FGIDs in Mexican school-aged children and adolescents. (C) 2016 Asociacion Mexicana de Gastroenterologia. Published by Masson Doyma Mexico S.A. AN - WOS:000425651900003 AU - Dhroove, G. AU - Saps, M. AU - Garcia-Bueno, C. AU - Jimenez, A. L. AU - Rodriguez-Reynosa, L. L. AU - Velasco-Benitez, C. A. DA - Jan-Mar DO - 10.1016/j.rgmx.2016.05.003 IS - 1 N1 - Dhroove, G. Saps, M. Garcia-Bueno, C. Leyva Jimenez, A. Rodriguez-Reynosa, L. L. Velasco-Benitez, C. A. Velasco-Benitez, Carlos A/0000-0001-5647-3024 PY - 2017 SN - 0375-0906 SP - 13-18 ST - Prevalence of functional gastrointestinal disorders in Mexican schoolchildren T2 - Revista De Gastroenterologia De Mexico TI - Prevalence of functional gastrointestinal disorders in Mexican schoolchildren UR - ://WOS:000425651900003 VL - 82 ID - 2117 ER - TY - JOUR AB - Tension-type headaches, the most prevalent form of headache, are differentiated as being either episodic or chronic. The episodic form is a physiologic response to stress, anxiety, depression, emotional conflicts, fatigue, or repressed hostility. Treatment focuses on the use of over-the-counter or prescribed simple analgesics for pain relief. Successful treatment of the chronic form depends on recognition of depression or persistent anxiety states. Primary care physicians can effectively manage most of these patients with nonhabituating anxiolytic or antidepressant medications; however, referrals for psychotherapy may be required in some cases. When tension-type headaches occur in children and adolescents, the physician must explore the patient's family and social relationships as well as school performance. In addition to nonhabituating drug therapies, family counseling and biofeedback may be helpful. In coexisting migraine and tension-type headaches, nonhabituating analgesics may be used for the relief of acute pain; the use of ergotamine and triptans should be restricted to relief of the hard or sick headache. Tricyclic antidepressants or monoamine oxidase inhibitors are the gold standards for prophylaxis, although the selective serotonin reuptake inhibitors may be indicated in less severe cases. Several forms of biofeedback have also proved effective. Nonetheless, some patients with this form of headache may require psychiatric treatment for severe depression. AD - Diamond Headache Clinic, Chicago, Illinois, USA. AN - 10682186 AU - Diamond, S. DO - 10.1016/s1098-3597(99)90038-8 DP - NLM ET - 2000/02/22 IS - 6 KW - Adult Analgesics/*therapeutic use Anti-Anxiety Agents/therapeutic use Antidepressive Agents, Tricyclic/therapeutic use Anxiety/complications/drug therapy Biofeedback, Psychology Child Depression/complications/drug therapy Humans Prevalence Serotonin/metabolism Stress, Physiological/complications Tension-Type Headache/etiology/prevention & control/*therapy LA - eng N1 - Diamond, S Journal Article Review United States Clin Cornerstone. 1999;1(6):33-44. doi: 10.1016/s1098-3597(99)90038-8. PY - 1999 SN - 1098-3597 (Print) 1873-4480 SP - 33-44 ST - Tension-type headache T2 - Clin Cornerstone TI - Tension-type headache VL - 1 ID - 3532 ER - TY - JOUR AB - Background: Most available data on the prevalence and characteristics of back pain in schoolchildren is related to industrialised and developed countries. The aim of this study was to investigate the prevalence of low back pain (LBP) and potential risk factors among schoolchildren and adolescents in a developing country, Iran. Methods: A cross-sectional study was conducted among 1611 Iranian schoolchildren aged 11-14 years. A self-complete questionnaire was used to assess LBP prevalence, physical leisure activities, school-related and psychosocial factors. Results: The prevalence of LBP was 34.3%. Female gender (odds ratio [OR] = 1.57, 95% CI:1.28-1.94), family member with back pain (OR = 1.82, 95% CI: 1.40-2.36), difficulty in viewing the (black)board (OR = 1.50, 95% CI: 1.13-1.99), too much homework (OR = 1.47, 95% CI:1.09-1.99), time spend carrying a schoolbag (min/d) (OR = 1.37, 95% CI: 1.01-1.85), and psychosocial factors (emotional symptoms) (OR = 2.28, 95% CI: 1.54-3.39) were independently associated with LBP. Physical activity, having a job, watching television, using a computer, playing games and schoolbag weight had no effect. Conclusion: It can be concluded that both physical and psychosocial factors influenced the risk for LBP, but emotional symptoms had a stronger association with LBP than physical factors. Knowledge about LBP in school children and adolescents could be important in assessment and treatment of such symptoms in this population. AU - Dianat, Iman AU - Alipour, Arezou AU - Asghari Jafarabadi, Mohammad DA - 2017 DO - 10.15171/hpp.2017.39 DP - PubMed IS - 4 J2 - Health Promot Perspect KW - Children Classroom furniture Musculoskeletal Psychological Schoolbag LA - eng PY - 2017 SN - 2228-6497 SP - 223-229 ST - Prevalence and risk factors of low back pain among school age children in Iran T2 - Health Promotion Perspectives TI - Prevalence and risk factors of low back pain among school age children in Iran UR - http://www.ncbi.nlm.nih.gov/pubmed/29085800 VL - 7 ID - 70 ER - TY - JOUR AB - Background: Schoolchildren usually use school bags to carry their school materials. Carrying heavy school bags can cause several problems such as musculoskeletal problems among schoolchildren. The aim of this study was to investigate the association between the weight of school bags and the occurrence of low back, shoulder and hand/wrist symptoms among primary school children. Method: This cross-sectional, descriptive-analytical study was conducted among a sample of 307 elementary school children in Tabriz, Iran. Data were collected using a questionnaire and from measurement of the school bag weight, body weight and height of each participant. Data were analysed using SPSS software. Results: The average load carried by schoolchildren was 2.9 kg, representing approximately 10% of the children's body weight. Girls and lower grade children carried a greater percentage of their body weights. Approximately 86% of the children reported some kind of musculoskeletal symptoms. The occurrence of shoulder, wrists/hands, and low back pain among schoolchildren was 70%, 18.5% and 8.7%, respectively. The results of binary logistic regression indicated that the school bag weight (expressed as a percentage of body weight) was only significantly associated with hand/wrist symptoms (P<0.05). Girls were more likely to complaint from low back pain than boys were. Age was significantly negatively associated with hand/wrist symptoms. Body mass index was also significantly associated with shoulder symptoms. Conclusion: The results indicate a high prevalence of musculoskeletal symptoms among elementary schoolchildren. Preventive measures and appropriate guidelines with regard to safe load carriage in schoolchildren are therefore needed to protect this age group. AN - WOS:000435872100008 AU - Dianat, I. AU - Javadivala, Z. AU - Allahverdipour, H. DO - 10.5681/hpp.2011.008 IS - 1 N1 - Dianat, Iman Javadivala, Zeynab Allahverdipour, Hamid Javadivala, Zeinab/Y-2655-2019 Javadivala, Zeinab/0000-0003-0231-8189 PY - 2011 SN - 2228-6497 SP - 76-85 ST - School Bag Weight and the Occurrence of Shoulder, Hand/Wrist and Low Back Symptoms among Iranian Elementary Schoolchildren T2 - Health Promotion Perspectives TI - School Bag Weight and the Occurrence of Shoulder, Hand/Wrist and Low Back Symptoms among Iranian Elementary Schoolchildren UR - ://WOS:000435872100008 VL - 1 ID - 2518 ER - TY - JOUR AB - OBJECTIVE: To evaluate if perceived occupational factors are associated with insufficient free-time physical activity in Brazilian public school teachers. METHODS: The relationship between insufficient physical activity (< 150 minutes/week) and variables related to work was analyzed in 978 elementary and high school teachers calculating the prevalence ratio (PR) and 95% confidence interval (95%CI) in Poisson regression models, adjusted for sociodemographic and health variables. RESULTS: The prevalence of insufficient physical activity was 71.9%, and this condition was associated independently with the perception of bad or regular balance between personal and professional life (PR = 1.09; 95%CI 1.01-1.18), perception that standing time affects the work (PR = 1.16; 95%CI 1.01-1.34), low or very low perception of current ability for the physical requirements of work (PR = 1.21; 95%CI 1.08-1.35), and temporary employment contract (PR = 1.13; 95%CI 1.03-1.25). The teaching of physical education was associated with lower prevalence of insufficient physical activity (PR = 0.78; 95%CI 0.64-0.95). CONCLUSIONS: The perception of adverse working conditions is associated with increased prevalence of insufficient physical activity in teachers and should be considered for the promotion of physical activity in this population. OBJETIVO: Analisar se fatores ocupacionais percebidos estão associados à atividade física insuficiente no tempo livre em professores de escolas públicas. MÉTODOS: A relação entre atividade física insuficiente (< 150 minutos/semana) e variáveis relacionadas ao trabalho foi analisada em 978 professores do ensino fundamental e médio mediante o cálculo da razão de prevalência (RP) e intervalo de confiança de 95% (IC95%) em modelos de regressão de Poisson, ajustados por variáveis sociodemográficas e de saúde. RESULTADOS: A prevalência de atividade física insuficiente foi de 71,9%, e essa condição associou-se de maneira independente com percepção de equilíbrio entre vida pessoal e profissional ruim ou regular (RP = 1,09; IC95% 1,01-1,18), percepção de que o tempo de permanência em pé afeta o trabalho (RP = 1,16; IC95% 1,01-1,34), percepção de capacidade atual para as exigências físicas do trabalho baixa ou muito baixa (RP = 1,21; IC95% 1,08-1,35) e contrato de trabalho temporário (RP = 1,13; IC95% 1,03-1,25). Ministrar disciplina de educação física associou-se com menor prevalência de atividade física insuficiente (RP = 0,78; IC95% 0,64-0,95). CONCLUSÕES: A percepção de condições de trabalho negativas associa-se à maior prevalência de atividade física insuficiente em professores e devem ser consideradas para a promoção de atividade física nessa população. Publisher: Abstract available from the publisher. por AD - Programa de Pós-Graduação em Saúde Coletiva. Universidade Estadual de Londrina. Londrina, PR, Brasil. Departamento de Educação Física. Universidade Estadual de Londrina. Londrina, PR, Brasil. Departamento de Saúde Coletiva. Universidade Estadual de Londrina. Londrina, PR, Brasil. AN - 28746571 AU - Dias, D. F. AU - Loch, M. R. AU - González, A. D. AU - Andrade, S. M. AU - Mesas, A. E. C2 - PMC5510795 DA - Jul 20 DO - 10.1590/s1518-8787.2017051006217 DP - NLM ET - 2017/07/27 KW - Adult Age Distribution Age Factors Brazil/epidemiology Chronic Pain/epidemiology/etiology Cross-Sectional Studies Exercise/*physiology Female Humans Male Middle Aged Occupational Diseases/*epidemiology/*etiology/physiopathology Reference Values School Teachers/*statistics & numerical data *Sedentary Behavior Sex Distribution Socioeconomic Factors Surveys and Questionnaires Time Factors Workload/*statistics & numerical data LA - eng por N1 - 1518-8787 Dias, Douglas Fernando Loch, Mathias Roberto González, Alberto Durán Andrade, Selma Maffei de Mesas, Arthur Eumann Journal Article Observational Study Rev Saude Publica. 2017 Jul 20;51:68. doi: 10.1590/S1518-8787.2017051006217. PY - 2017 SN - 0034-8910 (Print) 0034-8910 SP - 68 ST - Insufficient free-time physical activity and occupational factors in Brazilian public school teachers T2 - Rev Saude Publica TI - Insufficient free-time physical activity and occupational factors in Brazilian public school teachers VL - 51 ID - 3692 ER - TY - JOUR AB - OBJECTIVE: To assess the influence of an educational intervention in reducing «fear-avoidance» (FA) and «pain catastrophising» (CAT) in a population with unspecific chronic low back pain (UCLBP), attending physiotherapy in Primary Health Care. A pragmatic quasi-experimental study was conducted in Health Centres of a Costa del Sol Health District. DESIGN: Quasi-experimental study. SETTING: Primary Health Care physiotherapy Back Schools in Health Centres of a Costa del Sol Health District. PARTICIPANTS: The selection criteria were: UCLBP; 18-65years; understanding of the Spanish language; absence of parallel educational interventions; absence of red flags; not showing cognitive impairment or fibromyalgia; absence of thoracic-lumbar surgery, and exercise tolerance. INTERVENTIONS: The control group received the usual Back Schools program. The experimental group also received a written document for home reading, plus the subsequent sharing, clarifying doubts, and beliefs and goals restructuring during the development of the sessions. Both interventions lasted about 280minutes (7 sessions×40min). RESULTS: The main variables included FA and CAT. Pain and disability were also assessed. Some «demographic» and «related disorder» variables were considered in the analysis. Statistically significant differences were observed in the experimental group versus control, in the variation of FA -14 (-25.5; 0) vs -4 (-13; 0) (P=.009), and CAT -9 (-18; -4) vs -4,5 (-8.25; 0) (P=.000), were observed. Also differences in disability (P=.046), but not in pain (P=.280). CONCLUSIONS: These results should be considered in light of possible limits imposed by the study. Its pragmatic nature would allow a potential transfer to usual care. Publisher: Abstract available from the publisher. spa AD - Distrito Sanitario Costa del Sol, Servicio Andaluz de Salud, Junta de Andalucía, Málaga, España. Electronic address: juanlu1x2@hotmail.com. U.G.C. Las Lagunas, Unidad de Fisioterapia, Distrito Sanitario Costa del Sol, Servicio Andaluz de Salud, Junta de Andalucía, Mijas-Costa, Málaga, España; Área de conocimiento de Fisioterapia, Departamento de Psiquiatría y Fisioterapia, Facultad de Ciencias de la Salud, Universidad de Málaga, Málaga, España. Unidad AME (IBIMA-FIMABIS), Málaga, España. U.G.C. Las Albarizas, Unidad de Fisioterapia, Distrito Sanitario Costa del Sol, Servicio Andaluz de Salud, Junta de Andalucía, Mijas-Costa, Málaga, España. AN - 26724987 AU - Díaz-Cerrillo, J. L. AU - Rondón-Ramos, A. AU - Pérez-González, R. AU - Clavero-Cano, S. C2 - PMC6877809 DA - Aug-Sep DO - 10.1016/j.aprim.2015.10.007 DP - NLM ET - 2016/01/05 IS - 7 KW - Adolescent Adult Aged Cognition *Cognitive Behavioral Therapy Female Humans Low Back Pain/*therapy Male Medicine Middle Aged Physical Therapy Modalities Primary Health Care Young Adult Atención primaria Catastrofismo Catastrophism Educación en salud Fear Fisioterapia Health education Low back pain Lumbalgia Miedo LA - spa N1 - 1578-1275 Díaz-Cerrillo, Juan Luis Rondón-Ramos, Antonio Pérez-González, Rita Clavero-Cano, Susana Clinical Trial Journal Article Aten Primaria. 2016 Aug-Sep;48(7):440-8. doi: 10.1016/j.aprim.2015.10.007. Epub 2015 Dec 24. OP - Ensayo no aleatorizado de una intervención educativa basada en principios cognitivo-conductuales para pacientes con lumbalgia crónica inespecífica atendidos en fisioterapia de atención primaria. PY - 2016 SN - 0212-6567 (Print) 0212-6567 SP - 440-8 ST - [Non-randomised trial of an educational intervention based on cognitive-behavioural principles for patients with chronic low back pain attended in Primary Care Physiotherapy] T2 - Aten Primaria TI - [Non-randomised trial of an educational intervention based on cognitive-behavioural principles for patients with chronic low back pain attended in Primary Care Physiotherapy] VL - 48 ID - 3890 ER - TY - JOUR AB - BACKGROUND: Persistent low back pain in the young remains a significant diagnostic and treatment challenge for clinicians. Traditionally, chronic low back pain in this population has been attributed to either serious undetected pathology or psychosocial etiologies. This assumption may be incorrect because patients in this population may have underlying juvenile degenerative disc disease (JDDD), an important pathological diagnosis in the adult population. PURPOSE: The purpose of this study is to report the presentation, radiographic findings, diagnosis, and treatment modalities of juvenile patients presenting with persistent low back pain for greater then 6 months. STUDY DESIGN: This is a retrospective review of patients less than 21 years old referred to a spine specialty practice with persistent low back pain. PATIENT SAMPLE: The charts of 1,877 patients less than 21 years old referred to a spine specialty practice for the evaluation of spinal problems. OUTCOME MEASURES: Magnetic resonance images (MRI) were obtained and reviewed by a neuroradiologist and two orthopedic surgeons. METHODS: Patients younger than 21 years old with persistent low back pain for greater that 6 months were identified. Patients with scoliosis, Scheuermann's kyphosis, spondylolisthesis, fracture, tumor, and metabolic bone disease were excluded. Standard demographic information, relevant medical history and physical examination findings were collected. Patients were evaluated with an MRI of their spines to detect any potential underlying pathology. The success of various treatment modalities used was reviewed. The findings of this study were correlated to those of the available literature following a thorough review. RESULTS: Seventy-six patients (34 males, 42 females) with degenerative disc disease were identified on MRI. The mean age was 17.1 years (range 11.5-21.0) with a mean body mass index (BMI) of 24.5 (range 17.7-35.4). Thirty-one had associated radiculopathy. There was I I smokers, 20 involved in athletics, 17 with co-morbidities, and 9 with a BMI greater than 30. A distinct subgroup of 13 patients with multilevel concurrent spinal stenosis was documented. Four of this subgroup required surgical intervention for severe radicular or claudication symptoms. The majority of JDDD patients were successfully treated with nonoperative modalities. CONCLUSION: The findings of this study question whether lumbosacral degenerative disc disease, commonly thought to exist only in an older population, in fact begins earlier in selected patients. Our study confirms the findings of others that there is a definite population of juveniles that present with chronic low back pain who have degenerative disc disease identified on MRI. Within this population is a subgroup of patients with concurrent congenital spinal stenosis. Most patients with JDDD appear to be well managed by traditional nonoperative treatment modalities. (c) 2007 Elsevier Inc. All rights reserved. AN - WOS:000251490100012 AU - Dimar, J. R. AU - Glassman, S. D. AU - Carreon, L. Y. DA - May-Jun DO - 10.1016/j.spinee.2006.03.008 IS - 3 N1 - Dimar, John R. Glassman, Steven D. Carreon, Leah Y. Carreon, Leah/AAM-6577-2021 Carreon, Leah/0000-0002-7685-9036 1878-1632 PY - 2007 SN - 1529-9430 SP - 332-337 ST - Juvenile degenerative disc disease: a report of 76 cases identified by magnetic resonance imaging T2 - Spine Journal TI - Juvenile degenerative disc disease: a report of 76 cases identified by magnetic resonance imaging UR - ://WOS:000251490100012 VL - 7 ID - 2691 ER - TY - JOUR AB - Pain experiences, learning, and genetic factors have been proposed to shape attentional and emotional processes related to pain. We aimed at investigating whether a singular major pain experience also changes cognitive-emotional processing. The influence of acute postoperative pain after cosmetic surgery of the thorax was tested in 80 preoperatively pain-free male individuals. Acute pain was measured as independent variable during the first week postsurgery by pain intensity ratings and the requested analgesic boluses (Patient-Controlled Epidural Analgesia (PCEA)). Pain catastrophizing (Pain Catastrophizing Scale (PCS)), pain anxiety (Pain Anxiety and Symptom Scale (PASS)), pain hypervigilance (Pain Vigilance and Awareness Questionnaire (PVAQ)), and attentional biases to emotionally loaded stimuli (including pain) in a dot-probe task were assessed 1 week, 3 months, and 6 months postsurgery as dependent variables. Hierarchical regression analyses were performed to test whether the 2 acute pain parameters can predict these cognitive-emotional variables. As a rigorous test, significant prediction was required in addition to the prediction of the dependent variables by themselves with lag-1. Acute pain (mainly the pain ratings) appeared to be a significant predictor for PCS, PASS, and PVAQ 1 week after surgery (deltaR(2) = [8.7% to 11.3%]). In contrast, the attentional biases in the dot-probe task could not be predicted by the pain ratings. The levels of pain catastrophizing and pain hypervigilance increased in the acute phase after surgery when influenced by acute pain and declined, along with pain anxiety, during the next 3 months. In conclusion, a one-time intense pain experience, such as acute postoperative pain, appeared to produce at least short-lived changes in the attentional and emotional processing of pain. (C) 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. AN - WOS:000327596200024 AU - Dimova, V. AU - Horn, C. AU - Parthum, A. AU - Kunz, M. AU - Schofer, D. AU - Carbon, R. AU - Griessinger, N. AU - Sittl, R. AU - Lautenbacher, S. DA - Dec DO - 10.1016/j.pain.2013.08.005 IS - 12 N1 - Dimova, Violeta Horn, Claudia Parthum, Andreas Kunz, Miriam Schoefer, Dorothea Carbon, Roman Griessinger, Norbert Sittl, Reinhard Lautenbacher, Stefan Kunz, Miriam/P-8160-2016 Kunz, Miriam/0000-0002-0740-6738; , Stefan/0000-0002-2829-347X 1872-6623 PY - 2013 SN - 0304-3959 SP - 2737-2744 ST - Does severe acute pain provoke lasting changes in attentional and emotional mechanisms of pain-related processing? A longitudinal study T2 - Pain TI - Does severe acute pain provoke lasting changes in attentional and emotional mechanisms of pain-related processing? A longitudinal study UR - ://WOS:000327596200024 VL - 154 ID - 2334 ER - TY - JOUR AB - BACKGROUND: A substantial number of children experience spinal pain, that is, back and/or neck pain. Today, no 'gold-standard' treatment for spinal pain in children exists, but manipulative therapy is increasingly being used in spite of a lack of evidence of its effectiveness. This study investigates the effectiveness of adding manipulative therapy to other conservative care for spinal pain in a school-based cohort of Danish children aged 9-15 years. METHODS AND FINDINGS: The design was a two-arm pragmatic randomised controlled trial, nested in a longitudinal open cohort study in Danish public schools. 238 children from 13 public schools were randomised individually from February 2012 to April 2014. A text message system and clinical examinations were used for data collection. Interventions included either (1) advice, exercises and soft-tissue treatment or (2) advice, exercises and soft-tissue treatment plus manipulative therapy. The primary outcome was number of recurrences of spinal pain. Secondary outcomes were duration of spinal pain, change in pain intensity and Global Perceived Effect.We found no significant difference between groups in the primary outcome (control group median 1 (IQR 1-3) and intervention group 2 (IQR 0-4), p=0.07). Children in the group receiving manipulative therapy reported a higher Global Perceived Effect: OR 2.22, (95% CI 1.19 to 4.15). No adverse events were reported. Main limitations are the potential discrepancy between parental and child reporting and that the study population may not be comparable to a normal care-seeking population. CONCLUSIONS: Adding manipulative therapy to other conservative care in school children with spinal pain did not result in fewer recurrent episodes. The choice of treatment-if any-for spinal pain in children therefore relies on personal preferences, and could include conservative care with and without manipulative therapy. Participants in this trial may differ from a normal care-seeking population. TRIAL REGISTRATION NUMBER: NCT01504698; Results. AU - Dissing, Kristina Boe AU - Hartvigsen, Jan AU - Wedderkopp, Niels AU - Hestbæk, Lise DA - 2018/09/10/ DO - 10.1136/bmjopen-2017-021358 DP - PubMed IS - 9 J2 - BMJ Open KW - Adolescent back pain Child clinical trials Conservative Treatment Denmark evidence based practice Exercise Therapy Female Humans Male manipulative therapy Musculoskeletal Manipulations Neck Pain paediatrics Pain Measurement randomized controlled trial Recurrence Schools Single-Blind Method LA - eng PY - 2018 SN - 2044-6055 SP - e021358 ST - Conservative care with or without manipulative therapy in the management of back and/or neck pain in Danish children aged 9-15 T2 - BMJ open TI - Conservative care with or without manipulative therapy in the management of back and/or neck pain in Danish children aged 9-15: a randomised controlled trial nested in a school-based cohort UR - http://www.ncbi.nlm.nih.gov/pubmed/30206079 VL - 8 ID - 64 ER - TY - JOUR AB - BACKGROUND: Spinal pain in children and adolescents is a common condition, usually transitory, but the picture of spinal pain still needs elucidation, mainly due to variation in measurement methods. The aim of this study was to describe the occurrence of spinal pain in 8-15 year-old Danish school children, over a 3-year period. Specifically determining the characteristics of spinal pain in terms of frequency and duration. METHODS: The study was a 3-year prospective longitudinal cohort study including 1400 school children. The outcomes were based on weekly text messages (SMS) to the parents inquiring about the child's musculoskeletal pain, and on clinical data from examinations of the children. RESULTS: The 3-year prevalence was 55%. The prevalence was 29%, 33% and 31% for each of the three study years respectively, and increased statistically significantly with age, especially for lumbopelvic pain. Most children had few and short-lasting episodes with spinal pain, but more than one out of five children had three or more episodes during a study year and 17% of all episodes lasted for more than 4 weeks. CONCLUSION: This study demonstrates that spinal pain is a substantial problem. Most episodes are brief, but there are a vast number of children with frequent and long-lasting episodes of spinal pain indicating a need for action regarding evidence-based prevention and management. AU - Dissing, Kristina Boe AU - Hestbæk, Lise AU - Hartvigsen, Jan AU - Williams, Christopher AU - Kamper, Steven AU - Boyle, Eleanor AU - Wedderkopp, Niels DA - 2017/03/27/ DO - 10.1186/s12891-017-1424-5 DP - PubMed IS - 1 J2 - BMC Musculoskelet Disord KW - Adolescent Adolescents Age Factors Back Pain Child Children Denmark Female Follow-Up Studies Humans Male Musculoskeletal Pain Pain Measurement Parents Prevalence Prospective Studies Spinal pain Surveys and Questionnaires Time Factors LA - eng PY - 2017 SN - 1471-2474 SP - 67 ST - Spinal pain in Danish school children - how often and how long? T2 - BMC musculoskeletal disorders TI - Spinal pain in Danish school children - how often and how long? The CHAMPS Study-DK UR - http://www.ncbi.nlm.nih.gov/pubmed/28343450 VL - 18 ID - 74 ER - TY - JOUR AB - BACKGROUND: A prospective study controlled for sex and age was conducted evaluating the success of a 3-week inpatient pain therapy after 3, 6 and 12 months for 200 children and adolescents severely disabled due to chronic pain. METHODS: The following validated German questionnaires were used: pain questionnaire (DSF-K/J/E), pain coping inventory (PPCI-R), anxiety questionnaire (AFS) and depression questionnaire (DIKJ). After an intention-to-treat analysis unifactorial und multifactorial variance analyses were conducted. A significance level of p<0.01 was used. RESULTS: Durable improvements were observed for average pain intensity, pain disability, days absent from school, depression and for passive and interaction-based pain coping strategies 3 months after finishing inpatient pain therapy. On the other hand general anxiety and school aversion were only reduced at 6 and 12 months, respectively. Girls reported more pain in general and during follow-up. Younger children relied in general more on others when dealing with their pain. CONCLUSION: An inpatient pain therapy can help children and adolescents severely disabled due to chronic pain not only in the short term but also in the long term. AD - Vodafone Stiftungsinstitut und Lehrstuhl für Kinderschmerztherapie und Pädiatrische Palliativmedizin, Vestische Kinder- und Jugendklinik Datteln, Universität Witten/Herdecke, Datteln. m.dobe@kinderklinik-datteln.de AN - 21594660 AU - Dobe, M. AU - Hechler, T. AU - Behlert, J. AU - Kosfelder, J. AU - Zernikow, B. DA - Aug DO - 10.1007/s00482-011-1051-2 DP - NLM ET - 2011/05/20 IS - 4 KW - Adaptation, Psychological Adolescent Anxiety/psychology/therapy Child Chronic Pain/psychology/*therapy Combined Modality Therapy Cooperative Behavior Depression/psychology/therapy *Disability Evaluation Follow-Up Studies Germany *Hospitalization Humans Interdisciplinary Communication Length of Stay Pain Measurement/psychology Patient Care Team Phobic Disorders/psychology/therapy Prospective Studies Sex Factors Surveys and Questionnaires LA - ger N1 - 1432-2129 Dobe, M Hechler, T Behlert, J Kosfelder, J Zernikow, B Controlled Clinical Trial English Abstract Journal Article Germany Schmerz. 2011 Aug;25(4):411-22. doi: 10.1007/s00482-011-1051-2. OP - Schmerztherapie bei Chronisch Schmerzkranken, Schwer Beeinträchtigten Kindern und Jugendlichen: Langzeiterfolge einer 3-Wöchigen Stationären Schmerztherapie. PY - 2011 SN - 0932-433x SP - 411-22 ST - [Pain therapy with children and adolescents severely disabled due to chronic pain: long-term outcome after inpatient pain therapy] T2 - Schmerz TI - [Pain therapy with children and adolescents severely disabled due to chronic pain: long-term outcome after inpatient pain therapy] VL - 25 ID - 3289 ER - TY - BOOK A2 - Dobe, M. A2 - Zernikow, B. AB - For many children experiencing chronic pain, effective treatment is possible in an outpatient setting. However, for children with a pain disorder that severely affects the patient's and his/her family's life (frequently missing school; social withdrawal), an inpatient interdisciplinary pain treatment is indicated. In this chapter, we first discuss the criteria used to determine the need and usefulness of inpatient pain treatment, then we discuss contraindications. AN - WOS:000550989700009 AU - Dobe, M. AU - Zernikow, B. DO - 10.1007/978-3-030-19201-3_5 N1 - Dobe, Michael Zernikow, Boris PY - 2019 SN - 978-3-030-19201-3; 978-3-030-19200-6 SP - 77-80 ST - When to Decide on In- or Outpatient Pain Treatment? T2 - Practical Treatment Options for Chronic Pain in Children and Adolescents: An Interdisciplinary Therapy Manual, 2nd Edition TI - When to Decide on In- or Outpatient Pain Treatment? UR - ://WOS:000550989700009 ID - 1962 ER - TY - JOUR AB - Children born very prematurely (< or =32 weeks) often exhibit visual-perceptual difficulties at school-age, even in the absence of major neurological impairment. The alterations in functional brain activity that give rise to such problems, as well as the relationship between adverse neonatal experience and neurodevelopment, remain poorly understood. Repeated procedural pain-related stress during neonatal intensive care has been proposed to contribute to altered neurocognitive development in these children. Due to critical periods in the development of thalamocortical systems, the immature brain of infants born at extremely low gestational age (ELGA; < or =28 weeks) may have heightened vulnerability to neonatal pain. In a cohort of school-age children followed since birth we assessed relations between functional brain activity measured using magnetoencephalogragy (MEG), visual-perceptual abilities and cumulative neonatal pain. We demonstrated alterations in the spectral structure of spontaneous cortical oscillatory activity in ELGA children at school-age. Cumulative neonatal pain-related stress was associated with changes in background cortical rhythmicity in these children, and these alterations in spontaneous brain oscillations were negatively correlated with visual-perceptual abilities at school-age, and were not driven by potentially confounding neonatal variables. These findings provide the first evidence linking neonatal pain-related stress, the development of functional brain activity, and school-age cognitive outcome in these vulnerable children. AU - Doesburg, Sam M. AU - Chau, Cecil M. AU - Cheung, Teresa P. L. AU - Moiseev, Alexander AU - Ribary, Urs AU - Herdman, Anthony T. AU - Miller, Steven P. AU - Cepeda, Ivan L. AU - Synnes, Anne AU - Grunau, Ruth E. DA - 2013/10// DO - 10.1016/j.pain.2013.04.009 DP - PubMed IS - 10 J2 - Pain KW - Child Child development Cognition Cognitive outcome Development Female Gestational Age Humans Infant, Extremely Low Birth Weight Infant, Extremely Premature Infant, Newborn Infant, Premature Longitudinal Studies Magnetoencephalography Male Neonatal pain Neural oscillation Pain Pain Measurement Perception Population Pregnancy Prematurity Preterm Resting-state Spontaneous brain activity Stress, Psychological Visual Cortex Visual perception LA - eng PY - 2013 SN - 1872-6623 SP - 1946-1952 ST - Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age T2 - Pain TI - Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age UR - http://www.ncbi.nlm.nih.gov/pubmed/23711638 VL - 154 ID - 90 ER - TY - JOUR AB - Resting cortical activity is characterized by a distinct spectral peak in the alpha frequency range. Slowing of this oscillatory peak toward the upper theta-band has been associated with a variety of neurological and neuropsychiatric conditions and has been attributed to altered thalamocortical dynamics. Children born very preterm exhibit altered development of thalamocortical systems. To test the hypothesis that peak oscillatory frequency is slowed in children born very preterm, we recorded resting magnetoencephalography (MEG) from school age children born very preterm (<= 32 wk gestation) without major intellectual or neurological impairment and age-matched full-term controls. Very preterm children exhibit a slowing of peak frequency toward the theta-band over bilateral frontal cortex, together with reduced alpha-band power over bilateral frontal and temporal cortex, suggesting that mildly dysrhythmic thalamocortical interactions may contribute to altered spontaneous cortical activity in children born very preterm. (Pediatr Res 70: 171-175, 2011) AN - WOS:000292949400010 AU - Doesburg, S. M. AU - Ribary, U. AU - Herdman, A. T. AU - Moiseev, A. AU - Cheung, T. AU - Miller, S. P. AU - Poskitt, K. J. AU - Weinberg, H. AU - Whitfield, M. F. AU - Synnes, A. AU - Grunau, R. E. DA - Aug DO - 10.1203/PDR.0b013e3182225a9e IS - 2 N1 - Doesburg, Sam M. Ribary, Urs Herdman, Anthony T. Moiseev, Alexander Cheung, Teresa Miller, Steven P. Poskitt, Kenneth J. Weinberg, Hal Whitfield, Michael F. Synnes, Anne Grunau, Ruth E. Miller, Steven/0000-0001-9102-9105; Ribary, Urs/0000-0002-1182-8052 PY - 2011 SN - 0031-3998 SP - 171-175 ST - Magnetoencephalography Reveals Slowing of Resting Peak Oscillatory Frequency in Children Born Very Preterm T2 - Pediatric Research TI - Magnetoencephalography Reveals Slowing of Resting Peak Oscillatory Frequency in Children Born Very Preterm UR - ://WOS:000292949400010 VL - 70 ID - 2484 ER - TY - JOUR AB - STUDY DESIGN: Cross-sectional baseline data set on the sagittal standing posture of 1196 adolescents. OBJECTIVE: To describe and quantify common variations in the sagittal standing alignment in boys and girls who are in the same phase of growth and to explore the association between habitual standing posture and measures for spinal pain. SUMMARY OF BACKGROUND DATA: Data on postural characteristics and spinal pain measures in adolescence are sparse, especially when somatic and biological maturity status is to be considered. Our understanding of the relationship between standing posture in the sagittal plane and spinal pain is also deficient. METHODS: A total of 639 boys (age [mean ± SD], 12.6 ± 0.54 yr) and 557 girls (10.6 ± 0.47 yr), with predicted years from peak height velocity (PHV) being 1.2 ± 0.71 and 1.2 ± 0.59 pre-PHV, respectively, were studied. Postural examination included the assessment of global alignment and local spinopelvic characteristics, using post hoc analyses of digital images and direct body measurements (palpation, digital inclinometry, and wheeled accelerometry). Spinal pain experience was assessed by questionnaire. RESULTS: A wide interindividual variation in sagittal posture characteristics was observed. Logistic regression analyses yielded global alignment parameters to be associated with low back pain (lifetime prevalence), neck pain (lifetime prevalence, 1-mo prevalence, and doctor visit), and thoracic spine pain (doctor visit) outcome measures. None of the included local spinopelvic parameters could be identified as an associated factor with measures of spinal pain. CONCLUSION: The orientation of gross body segments with respect to the gravity line seems superior to local spinopelvic features in terms of clinical importance, at least in the current pre-PHV cohort. Opportunities may exist for postural subgrouping strategies to begin with global alignment parameters in order to gain further insight into the relationship between sagittal alignment and the relative risk of developing spinal pain/seeking medical consultation for this pain. AU - Dolphens, Mieke AU - Cagnie, Barbara AU - Coorevits, Pascal AU - Vanderstraeten, Guy AU - Cardon, Greet AU - Dʼhooge, Roseline AU - Danneels, Lieven DA - 2012/09/01/ DO - 10.1097/BRS.0b013e3182408053 DP - PubMed IS - 19 J2 - Spine (Phila Pa 1976) KW - Adolescent Anthropometry Back Pain Belgium Body Height Child Cross-Sectional Studies Female Humans Male Neck Pain Office Visits Posture Prevalence School Health Services Sex Characteristics Spine Surveys and Questionnaires LA - eng PY - 2012 SN - 1528-1159 SP - 1657-1666 ST - Sagittal standing posture and its association with spinal pain T2 - Spine TI - Sagittal standing posture and its association with spinal pain: a school-based epidemiological study of 1196 Flemish adolescents before age at peak height velocity UR - http://www.ncbi.nlm.nih.gov/pubmed/22108378 VL - 37 ID - 100 ER - TY - JOUR AB - INTRODUCTION: Type 2 diabetes mellitus compromises physical, psychological, economic, and social life. OBJECTIVES: To identify and compare the quality of life, depression, functional performance, and physical activity in patients with type 2 diabetes mellitus who use insulin or not. METHODS: A observational, descriptive, cross-sectional, comparative study involving 100 patients (50 use insulin and 50 do not) from a Teaching Hospital. Questionnaires used: Identification and Socioeconomic Profile; SF-36; Hospital Anxiety and Depression Scale; Visual Analogue Scale for Pain; Canadian Occupational Performance Measure, and International Physical Activity Questionnaire. RESULTS: Sample composed predominantly by middle-aged, female, married, retired, and with incomplete elementary school individuals. There is impairment in all domains of quality of life, being more intense in functional capacity, physical limitations, pain, social aspects, limitation by emotional aspects, and mental health (P<0.05). There is a significant prevalence of anxiety or depressive symptoms in the groups, especially in those using insulin. However, the occurrence of the corresponding psychiatric disorders is unlikely (P<0.05). There was no significant difference in neuropathic pain between the groups (P=0.2296). Functional impairment is similar in both groups regarding self-care activities (P=0.4494) and productivity (P=0.5759), with a greater deterioration of leisure time in patients on insulin (P=0.0091). Most of them practice physical activity, predominantly walking, with no significant difference when comparing the groups (P>0.05), as well as in the other modalities. CONCLUSION: Insulinized patients present greater impairment of functional capacity and socialization, as well as greater neuropathic pain, anxiety, and depressive symptoms. AN - WOS:000510392000010 AU - dos Reis, A. C. AU - Cunha, M. V. AU - Bianchin, M. A. AU - Freitas, M. T. R. AU - Castiglioni, L. DA - Dec DO - 10.1590/1806-9282.65.12.1464 IS - 12 N1 - dos Reis, Ana Carolina Cunha, Milena Vizioli Bianchin, Maysa Alahmar Rui Freitas, Maristella Tonon Castiglioni, Lilian Castiglioni, Lilian/C-2687-2014 Castiglioni, Lilian/0000-0002-9999-2673; Reis, AlessanRSS/0000-0001-8486-7469; Dos Reis, Ana Carolina/0000-0001-9044-1317 1806-9282 PY - 2019 SP - 1464-1469 ST - Comparison of quality of life and functionality in type 2 diabetics with and without insulin T2 - Revista Da Associacao Medica Brasileira TI - Comparison of quality of life and functionality in type 2 diabetics with and without insulin UR - ://WOS:000510392000010 VL - 65 ID - 1865 ER - TY - JOUR AB - Psychogenic nonepileptic seizures is a complicated biopsychosocial disorder with significant morbidity and high cost in children's social, emotional, family, and academic functioning as well as health care service utilization. Misdiagnosis and diagnostic delay, resulting from both lack of access to approved standards for diagnosing and service providers comfortable with diagnosing and treating this disorder, affect prognosis. Treatment in close proximity to symptom onset is thought to provide the best chance for remission. AN - WOS:000418991100006 AU - Doss, J. L. AU - Plioplys, S. DA - Jan DO - 10.1016/j.chc.2017.08.007 IS - 1 N1 - Doss, Julia L. Plioplys, Sigita 1558-0490 PY - 2018 SN - 1056-4993 SP - 53-+ ST - Pediatric Psychogenic Nonepileptic Seizures A Concise Review T2 - Child and Adolescent Psychiatric Clinics of North America TI - Pediatric Psychogenic Nonepileptic Seizures A Concise Review UR - ://WOS:000418991100006 VL - 27 ID - 2055 ER - TY - JOUR AB - Musculoskeletal complaints are symptoms frequently encountered by the pediatric practitioner. The causes are most frequently minor traumatic events or joint and muscle stress; postinfectious joint complaints are also not uncommon. Musculoskeletal complaints of long duration or in multiple locations, however, require more in-depth examination. If a thorough work-up does not detect an underlying organic disorder, a chronic pain syndrome is the most probable cause. The two forms most frequently encountered are the chronic pain disorders of multiple body regions with somatic and psychological factors and the complex regional pain syndrome (CRPS), which differ substantially in their pathogenesis and clinical picture. Both require a specialized team for diagnostics and successful treatment and a multidisciplinary collaboration of physicians, nurses, physiotherapists, psychologist and other specialties in a multimodal setting is the key. AN - WOS:000436807400008 AU - Draheim, N. AU - Hugle, B. DA - Jul DO - 10.1007/s00112-018-0492-4 IS - 7 N1 - Draheim, N. Huegle, B. Hugle, Boris/AAN-3064-2020 1433-0474 PY - 2018 SN - 0026-9298 SP - 585-591 ST - Chronic musculoskeletal pain in children and adolescents T2 - Monatsschrift Kinderheilkunde TI - Chronic musculoskeletal pain in children and adolescents UR - ://WOS:000436807400008 VL - 166 ID - 2009 ER - TY - JOUR AB - OBJECTIVES: Describe the pattern of utilization and effectiveness of outpatient fracture pain medication. METHODS: A cross-sectional survey of caregivers of children with an isolated extremity fracture at a hospital-based pediatric orthopedic clinic during initial follow-up. RESULTS: Surveys were completed by 98 (79.2%) of 125 caregivers. Mean age of children was 9 years (range, 1-18 years). Fracture sites include arm (36%), wrist (24%), hand (6%), leg (14%), ankle (9%), and foot (6%). Pain was reported "worst" at the time of injury in 45.3% patients (95% confidence interval [CI], 35.0%-55.8%) and in the first 48 hours of injury in 30.5% patients (95% CI, 21.5%-40.8%). The most commonly used medications were ibuprofen 43.5% (95% CI, 34.4%-52.5%) and acetaminophen with codeine 26.1% (95% CI, 18.1%-34.1%). Mean duration of medication use was 3.2 days (95% CI, 2.8-3.6 days). The mean duration of functional limitations included 4.2 days (95% CI, 2.8-5.5 days) for playing, 2.6 days (95% CI, 1.7-3.4 days) for performing at school, 2.4 days (95% CI, 1.8-3.0 days) for sleeping, and 2.0 days (95% CI, 1.0-3.0 days) for eating. Mean days of work missed by caregivers was 1.6 (95% CI, 1.1-2.0 days), and days of school missed by children was 2.0 (95% CI, 1.6-2.3